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https://www.readbyqxmd.com/read/29229270/intratracheal-instillation-of-alveolar-type-ii-cells-enhances-recovery-from-acute-lung-injury-in-rats
#1
Raquel Guillamat-Prats, Ferranda Puig, Marta Camprubí-Rimblas, Raquel Herrero, Anna Serrano-Mollar, Maria Nieves Gómez, Jessica Tijero, Michael A Matthay, Lluís Blanch, Antonio Artigas
BACKGROUND: Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are characterized by excess production of inflammatory factors. Alveolar type II (ATII) cells help repair damaged lung tissue, rapidly proliferating and differentiating into alveolar type I cells after epithelial cell injury. In ALI, the lack of viable ATII favors progression to more severe lung injury. ATII cells regulate the immune response by synthesizing surfactant and other anti-inflammatory proteins and lipids...
November 8, 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/29229114/estradiol-mediates-the-long-lasting-lung-inflammation-induced-by-intestinal-ischemia-and-reperfusion
#2
Evelyn Thais Fantozzi, Ana Cristina Breithaupt-Faloppa, Fernanda Yamamoto Ricardo-da-Silva, Sara Rodrigues-Garbin, Daniel Cancelli Romero, Adriana da Silva Rodrigues, Yanira Riffo-Vasquez, Wothan Tavares-de-Lima
BACKGROUND: Lung inflammation is one of the main consequences of intestinal ischemia reperfusion (intestinal IR) and, in severe cases, can lead to acute respiratory distress syndrome and death. We have previously demonstrated that estradiol exerts a protective effect on lung edema and cytokine release caused by intestinal IR in male rats. MATERIALS AND METHODS: We investigated the role of estradiol on the generation of interleukin (IL)-1β, IL-10, vascular endothelial growth factor (VEGF), and cytokine-induced neutrophil chemoattractant 1 (CINC-1) in a female rat model of intestinal IR...
January 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29223534/systemic-recovery-and-therapeutic-effects-of-transplanted-allogenic-and-xenogenic-mesenchymal-stromal-cells-in-a-rat-blunt-chest-trauma-model
#3
Elisa Maria Amann, Markus Thomas Rojewski, Sinja Rodi, Daniel Fürst, Jörg Fiedler, Annette Palmer, Sonja Braumüller, Markus Huber-Lang, Hubert Schrezenmeier, Rolf Erwin Brenner
BACKGROUND: Effective therapy of Acute Lung Injury (ALI) is still a major scientific and clinical problem. To define novel therapeutic strategies for sequelae of blunt chest trauma (TxT) like ALI/Acute Respiratory Distress Syndrome, we have investigated the immunomodulatory and regenerative effects of a single dose of ex vivo expanded human or rat mesenchymal stromal cells (hMSCs/rMSCs) with or without priming, immediately after the induction of TxT in Wistar rats. METHODS: We analyzed the histological score of lung injury, the cell count of the broncho alveolar lavage fluid (BAL), the change in local and systemic cytokine level and the recovery of the administered cells 24 h and 5 days post trauma...
December 6, 2017: Cytotherapy
https://www.readbyqxmd.com/read/29202212/nebulized-heparin-attenuates-pulmonary-coagulopathy-and-inflammation-through-alveolar-macrophages-in-a-rat-model-of-acute-lung-injury
#4
Laura Chimenti, Marta Camprubí-Rimblas, Raquel Guillamat-Prats, Maria Nieves Gomez, Jessica Tijero, Lluis Blanch, Antonio Artigas
Objective Alveolar macrophages play a key role in the development and resolution of acute respiratory distress syndrome (ARDS), modulating the inflammatory response and the coagulation cascade in lungs. Anti-coagulants may be helpful in the treatment of ARDS. This study investigated the effects of nebulized heparin on the role of alveolar macrophages in limiting lung coagulation and inflammatory response in an animal model of acute lung injury (ALI). Methods Rats were randomized to four experimental groups...
November 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29179596/celastrol-attenuates-impairments-associated-with-lipopolysaccharide-induced-acute-respiratory-distress-syndrome-ards-in-rats
#5
Yongjun Wei, Yu Wang
Celastrol, a constituent from a traditional Chinese medicinal herb belonging to the family Celastraceae, has been shown to impart anti-inflammatory properties, in part, by inhibiting NF-κB activity and related induction of pro-inflammatory cytokine formation/release. The present study investigated the effects of celastrol in an animal model of acute respiratory distress syndrome (ARDS) induced by intratracheal administration of lipopolysaccharides (LPSs). Celastrol pre-treatment groups received celastrol by intraperitoneal injection on seven consecutive days before LPS treatment...
December 2017: Journal of Immunotoxicology
https://www.readbyqxmd.com/read/29137274/effective-protection-against-acute-respiratory-distress-syndrome-sepsis-injury-by-combined-adipose-derived-mesenchymal-stem-cells-and-preactivated-disaggregated-platelets
#6
Chih-Hung Chen, Yung-Lung Chen, Pei-Hsun Sung, Cheuk-Kwan Sun, Kuan-Hung Chen, Yi-Ling Chen, Tien-Hung Huang, Hung-I Lu, Fan-Yen Lee, Jiunn-Jye Sheu, Sheng-Ying Chung, Mel S Lee, Hon-Kan Yip
This study assessed whether combining adipose-derived mesenchymal stem cells (ADMSC) with preactivated, disaggregated shape-changed platelets (PreD-SCP) was superior to either therapy alone for protecting rat lung from acute respiratory distress syndrome (ARDS) complicated by sepsis. ARDS and sepsis were induced through 100% oxygen inhalation and peritoneal administration of 1.5 mg/kg lipopolysaccharide (LPS), respectively. Adult-male Sprague-Dawley rats (n=40) were randomized into sham-control (SC), ARDS-LPS, ARDS-LPS-ADMSC (1...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29116998/mesenchymal-stem-cells-from-bone-marrow-adipose-tissue-and-lung-tissue-differentially-mitigate-lung-and-distal-organ-damage-in-experimental-acute-respiratory-distress-syndrome
#7
Johnatas D Silva, Miquéias Lopes-Pacheco, Ana H R Paz, Fernanda F Cruz, Elga B Melo, Milena V de Oliveira, Débora G Xisto, Vera L Capelozzi, Marcelo M Morales, Paolo Pelosi, Elizabeth Cirne-Lima, Patricia R M Rocco
OBJECTIVES: Mesenchymal stem cells-based therapies have shown promising effects in experimental acute respiratory distress syndrome. Different mesenchymal stem cells sources may result in diverse effects in respiratory diseases; however, there is no information regarding the best source of mesenchymal stem cells to treat pulmonary acute respiratory distress syndrome. We tested the hypothesis that mesenchymal stem cells derived from bone marrow, adipose tissue, and lung tissue would lead to different beneficial effects on lung and distal organ damage in experimental pulmonary acute respiratory distress syndrome...
November 7, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/29102631/edaravone-attenuates-lipopolysaccharide-induced-acute-respiratory-distress-syndrome-associated-early-pulmonary-fibrosis-via-inhibition-of-oxidative-stress-and-transforming-growth-factor-%C3%AE-1-smad3-signaling
#8
Xida Wang, Rongde Lai, Xiangfen Su, Guibin Chen, Zijing Liang
Pulmonary fibrosis is responsible for the both short-term and long-term outcomes in patients with acute respiratory distress syndrome (ARDS). There is still no effective cure to improve prognosis. The purpose of this study was to investigate whether edaravone, a free radical scavenger, have anti-fibrosis effects in the rat model of ARDS associated early pulmonary fibrosis by lipopolysaccharide (LPS) administration. Rats were subjected to intravenous injection of LPS, and edaravone was given intraperitoneally after LPS administration daily for 7 consecutive days...
November 1, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29098546/silymarin-mitigates-lung-impairments-in-a-rat-model-of-acute-respiratory-distress-syndrome
#9
Zhongming Zhu, Gengyun Sun
Acute respiratory distress syndrome (ARDS) is a deadly disease and lacks effective treatments. Inflammation and oxidative stress play key roles in ARDS development. We aimed to evaluate the efficacy of pretreatment of silymarin, which has capacities of anti-inflammatory and anti-oxidative stress, in ARDS. We used lipopolysaccharide (LPS) to generate an ARDS rat model, which was pretreated with silymarin. Lung wet/dry ratio and broncho-alveolar lavage fluid (BALF) analyses were performed. Histological changes of the lungs were evaluated using hematoxylin and eosin staining...
November 2, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/29096562/alpha-1-antitrypsin-ameliorates-ventilator-induced-lung-injury-in-rats-by-inhibiting-inflammatory-responses-and-apoptosis
#10
He Zhu, Jianshuai He, Jia Liu, Xin Zhang, Fengyun Yang, Pingting Liu, Shilei Wang
Mechanical ventilation is extensively used to treat patients with lung injury but may result in ventilator-induced lung injury (VILI). The present study investigated the protective effect of alpha 1-antitrypsin (AAT) on VILI. Adult male rats were subjected to sham, ventilation + saline, or ventilation + AAT treatment and lung injuries were evaluated. Peripheral blood and bronchoalveolar lavage fluid (BALF) were obtained to assess systemic and local inflammatory responses, respectively. Mechanical ventilation resulted in lung injury, as evidenced by histological abnormalities as well as elevations in PaO2/FiO2 ratio, the wet-to-dry weight ratio, and the BALF level of proteins...
January 1, 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29052821/evaluation-of-the-systemic-antiinflammatory-effects-of-levosimendan-in-an-experimental-blunt-thoracic-trauma-model
#11
Gökay Ateş, Ferda Yaman, Bülent Bakar, Üçler Kısa, Pınar Atasoy, Ünase Büyükkoçak
BACKGROUND: Blunt thoracic injury often leads to pulmonary contusion and the development of acute respiratory distress syndrome, which carries a high risk of morbidity and mortality, originating from the local and systemic inflammatory states. This study aimed to investigate the local and systemic antiinflammatory effects of levosimendan in rat models of blunt chest trauma. METHODS: A total of 32 Wistar albino rats were randomly assigned to one of the following four groups: control, sham, low-dose levosimendan (LDL) (5 µg/kg loading dose for 10 min and 0...
September 2017: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/29039541/modulation-of-mitogen%C3%A2-activated-protein-kinase-attenuates-sepsis%C3%A2-induced-acute-lung-injury-in-acute-respiratory-distress-syndrome-rats
#12
Wei Fang, Shi-Xia Cai, Chuan-Lei Wang, Xiao-Xia Sun, Kun Li, Xiao-Wen Yan, Yun-Bo Sun, Xiao-Zhe Sun, Chuan-Kai Gu, Ming-Ying Dai, Hui-Ming Wang, Zhen Zhou
Sepsis is the most important predisposing cause inducing acute respiratory distress syndrome (ARDS); however, the mechanism of sepsis leading to the development of ARDS remains to be elucidated. Suppression of the mitogen‑activated protein kinase (MAPK) signal by blocking the phosphorylation of Jun N‑terminal kinase (JNK) and p38 in lung tissues could alleviate acute lung injury induced by sepsis. MAPK signaling may have a crucial role in development of the sepsis‑induced acute lung injury. The specific inhibitors of JNK and p38 MAPK, SP600125 and SB203580, were administrated by intragastric injection 4 h before induction of ARDS after cecal ligation and puncture (CLP)...
December 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28972887/lianqinjiedu-decoction-attenuates-lps-induced-inflammation-and-acute-lung-injury-in-rats-via-tlr4-nf-%C3%AE%C2%BAb-pathway
#13
Guiming Deng, Hai He, Zheng Chen, Linqi OuYang, Xiaoqin Xiao, Jinwen Ge, Biao Xiang, Sichen Jiang, Shaowu Cheng
Acute lung injury (ALI) and its severe form acute respiratory distress syndrome remain the leading cause of morbidity and mortality. LianQinJieDu (LQJD), which is a traditional Chinese medicine, has been clinically used for antiviral drug. The present study investigated whether Lianqinjiedu(LQJD) ameliorates lipopolysaccharide(LPS)-induced acute lung injury in rats and aimed to determine the anti-inflammatory effects of LQJD. Rat model with ALI induced by intraperitoneal injection of LPS was treated by oral administration of LQJD...
September 30, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28946699/evaluation-of-lps-induced-acute-lung-injury-attenuation-in-rats-by-aminothiazole-paeonol-derivatives
#14
Pin-Kuei Fu, Chi-Yu Yang, Su-Chin Huang, Yu-Wen Hung, Kee-Ching Jeng, Ying-Pei Huang, Hong Chuang, Nai-Chun Huang, Jui-Ping Li, Ming-Hua Hsu, Jen-Kun Chen
Paeonol is a key phenolic compound in the root bark of Moutan Cortex Radicis that has been used in traditional Chinese Medicine to ameliorate inflammation. A series of aminothiazole-paeonol derivatives (APDs) were synthesized in this work and subjected to preliminary evaluation in cells followed by verification in animals. Quantification of monocyte chemotactic protein-1 (MCP-1) and interleukin-6 (IL-6) in culture media of LPS-activated A549 cells, a lung epithelial adenocarcinoma cell line, were used to investigate the anti-inflammatory capability of APDs...
September 25, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28944852/use-of-immunoproteomics-to-identify-immunogenic-proteins-in-a-rat-model-of-acute-respiratory-distress-syndrome
#15
Zongshu Ji, Haiyan Liu, Linsen Fang, Youxin Yu, Zheng Zhou
Acute respiratory distress syndrome (ARDS) is a common and life‑threatening clinical syndrome, and seeking biomarkers of ARDS has been an area of continuing research. The present study hypothesized that alterations to certain immunogenic substances occur in injured lungs and are able to specifically bind with corresponding proteins in the blood, and that these proteins may be readily detected. To investigate this hypothesis, a rat model of ARDS was established by cecal ligation and puncture surgery, and an immunoproteomics approach, using serum as the primary antibody in a western blot analysis, was used with the aim of identifying immunogenic proteins in the injured lungs...
November 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944831/vitamin-d-alleviates-lipopolysaccharide%C3%A2-induced-acute-lung-injury-via-regulation-of-the-renin%C3%A2-angiotensin-system
#16
Jun Xu, Jialai Yang, Jian Chen, Qingli Luo, Qiu Zhang, Hong Zhang
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are the clinical manifestations of severe lung damage and respiratory failure. ALI and ARDS result are associated with high mortality in patients. At present, no effective treatments for ALI and ARDS exist. It is established that vitamin D exhibits anti‑inflammatory effects, however, the specific effect of vitamin D on ALI remains largely unknown. The aim of the present study was to investigate whether, and by which mechanism, vitamin D alleviates lipopolysaccharide (LPS)‑induced ALI...
November 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28870649/lipopolysaccharide-impairs-permeability-of-pulmonary-microvascular-endothelial-cells-via-connexin40
#17
Hua-Song Zhou, Meng Li, Bing-Dong Sui, Lei Wei, Rui Hou, Wen-Sheng Chen, Qiang Li, Sheng-Hui Bi, Jin-Zhou Zhang, Ding-Hua Yi
The endotoxin lipopolysaccharide (LPS)-induced pulmonary endothelial barrier disruption is a key pathogenesis of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). However, the molecular mechanisms underlying LPS-impaired permeability of pulmonary microvascular endothelial cells (PMVECs) are not fully understood. Gap junctions, particularly Connexin40 (Cx40), are necessary for the maintenance of normal vascular function. In this study, we for the first time investigated the role of Cx40 in LPS-impaired permeability of PMVECs and provided potential therapeutic approaches based on mechanistic findings of Cx40 regulation by LPS stimuli...
January 2018: Microvascular Research
https://www.readbyqxmd.com/read/28864418/the-expression-profiles-of-circrnas-in-lung-tissues-from-rats-with-lipopolysaccharide-induced-acute-respiratory-distress-syndrome-a-microarray-study
#18
Qi-Quan Wan, Di Wu, Qi-Fa Ye
The development of circular RNA (circRNA) microarray has facilitated the study of the role of circRNAs in regulating gene expression through a circRNA-miRNA-mRNA network. In our study, microarray was performed to detect the expression profiles of circRNAs during lipopolysaccharide (LPS)-induced acute respiratory distress syndrome (ARDS). Twenty rats were randomly divided into 2 groups, the control group and the LPS group, 10 rats in each group. Three rats each from both groups were randomly selected. Using circRNA microarray data, we compared the circRNA expression profiles in lung tissues between these 6 rats...
November 4, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28815665/pharmacological-modulation-of-c-x-c-motif-chemokine-receptor-4-influences-development-of-acute-respiratory-distress-syndrome-after-lung-ischemia-reperfusion-injury
#19
Sean P Nassoiy, Favin S Babu, Heather M LaPorte, Matthias Majetschak
Activation of CXC motif chemokine receptor 4 (CXCR4) has been reported to result in lung protective effects in various experimental models. The effects of pharmacological CXCR4 modulation on the development of acute respiratory distress syndrome (ARDS) after lung injury, however, are unknown. Thus, we studied whether blockade and activation of CXCR4 influences development of ARDS in a unilateral lung ischemia-reperfusion injury rat model. Anesthetized, mechanically ventilated animals underwent right lung ischemia (series 1: 30 min; series 2: 60 min) followed by reperfusion for 300 min...
August 16, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/28807204/anti-inflammatory-effect-of-dexmedetomidine-combined-with-hypothermia-on-acute-respiratory-distress-syndrome-in-rats
#20
Xianfeng Chen, Lili Li, Juntao Hu, Chi Zhang, Yiping Pan, Diansheng Tian, Zhanhong Tang
BACKGROUND: To investigate the protective effect of combination of dexmedetomidine and hypothermia on lipopolysaccharide (LPS) induced acute respiratory distress syndrome in rats. METHODS: Fifty male Wistar rats were randomly divided into five groups, with 10 rats in each group. The acute respiratory distress syndrome model was reproduced by LPS injected into the right external jugular vein (L group); only saline was injected into the right external jugular vein for control group (C group)...
August 2017: Journal of Surgical Research
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