Robert S Foti, Kaustav Biswas, Jennifer Aral, Xuhai Be, Loren Berry, Yuan Cheng, Kip Conner, James R Falsey, Charles Glaus, Brad Herberich, Dean Hickman, Tayo Ikotun, Hongyan Li, Jason Long, Liyue Huang, Les P Miranda, Justin Murray, Bryan Moyer, Chawita Netirojjanakul, Thomas E Nixey, Kelvin Sham, Marcus Soto, Christopher M Tegley, Linh Tran, Bin Wu, Lin Yin, Dan A Rock
The identification of non-opioid alternatives to treat chronic pain has received a great deal of interest in recent years. Recently, the engineering of a series of Nav1.7 inhibitory peptide-antibody conjugates has been reported and herein, the preclinical efforts to identify novel approaches to characterize the pharmacokinetic properties of the peptide conjugates are described. A cryopreserved plated mouse hepatocyte assay was designed to measure the depletion of the peptide-antibody conjugates from the media, with a correlation being observed between percent remaining in the media and in vivo clearance (Pearson r = -0...
August 6, 2019: Drug Metabolism and Disposition: the Biological Fate of Chemicals