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appearance is a function of face

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https://www.readbyqxmd.com/read/28411271/neural-correlates-of-semantic-prediction-and-resolution-in-sentence-processing
#1
Luigi Grisoni, Tally McCormick Miller, Friedemann Pulvermüller
Most brain imaging studies of language comprehension focus on activity following upon meaningful stimuli. Testing adult human participants with high-density EEG, we show that, already before the presentation of a critical word, context-induced semantic predictions are reflected by a neurophysiological index, which we therefore call the Semantic Readiness Potential (SRP). The SRP precedes critical words if previous sentence context constrains the upcoming semantic content (High-constraint contexts), but not in unpredictable (Low-constraint) contexts...
April 14, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28410650/prehabilitation-for-the-frail-patient-approaching-esrd
#2
REVIEW
Anoop Sheshadri, Kirsten L Johansen
Frailty is a distinct phenotype that is highly prevalent in chronic kidney disease (CKD) and appears to be more prevalent with decreasing glomerular filtration rate. Exercise training or intervention to increase physical activity may ameliorate poor physical functioning and frailty, and even may improve survival in patients with CKD. Although exercise interventions improve outcomes across the spectrum of CKD, including patients treated with dialysis, patients treated with dialysis face barriers to exercise that patients with predialysis CKD do not...
March 2017: Seminars in Nephrology
https://www.readbyqxmd.com/read/28406382/reading-what-the-mind-thinks-from-how-the-eye-sees
#3
Daniel H Lee, Adam K Anderson
Human eyes convey a remarkable variety of complex social and emotional information. However, it is unknown which physical eye features convey mental states and how that came about. In the current experiments, we tested the hypothesis that the receiver's perception of mental states is grounded in expressive eye appearance that serves an optical function for the sender. Specifically, opposing features of eye widening versus eye narrowing that regulate sensitivity versus discrimination not only conveyed their associated basic emotions (e...
April 2017: Psychological Science
https://www.readbyqxmd.com/read/28395026/the-structural-role-of-elastic-fibers-in-the-cornea-investigated-using-a-mouse-model-for-marfan-syndrome
#4
Tomas L White, Philip Lewis, Sally Hayes, James Fergusson, James Bell, Luis Farinha, Nick S White, Lygia V Pereira, Keith M Meek
Purpose: The presence of fibrillin-rich elastic fibers in the cornea has been overlooked in recent years. The aim of the current study was to elucidate their functional role using a mouse model for Marfan syndrome, defective in fibrillin-1, the major structural component of the microfibril bundles that constitute most of the elastic fibers. Methods: Mouse corneas were obtained from animals with a heterozygous fibrillin-1 mutation (Fbn1+/-) and compared to wild type controls...
April 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28384543/novel-organophosphorus-scaffolds-of-urease-inhibitors-obtained-by-substitution-of-morita-baylis-hillman-adducts-with-phosphorus-nucleophiles
#5
Vassilis Ntatsopoulos, Stamatia Vassiliou, Katarzyna Macegoniuk, Łukasz Berlicki, Artur Mucha
The reactivity of Morita-Baylis-Hillman allyl acetates was employed to introduce phosphorus-containing functionalities to the side chain of the cinnamic acid conjugated system by nucleophilic displacement. The proximity of two acidic groups, the carboxylate and phosphonate/phosphinate groups, was necessary to form interactions in the active site of urease by recently described inhibitor frameworks. Several organophosphorus scaffolds were obtained and screened for inhibition of the bacterial urease, an enzyme that is essential for survival of urinary and gastrointestinal tract pathogens...
March 29, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28378386/why-do-people-with-dementia-pretend-to-know-the-correct-answer-a-qualitative-study-on-the-behaviour-of-toritsukuroi-to-keep-up-appearances
#6
Masateru Matsushita, Yusuke Yatabe, Asuka Koyama, Yukiko Ueno, Daisuke Ijichi, Hiroto Ikezaki, Mamoru Hashimoto, Noboru Furukawa, Manabu Ikeda
BACKGROUND: Toritsukuroi is a particular type of behaviour intended to save face or preserve appearances. Clinicians often observe toritsukuroi in people with dementia, but current knowledge about this behaviour is based on clinicians' empirical knowledge rather than on observational studies. This study was designed to clarify which behaviours are related to toritsukuroi based on neuropsychological examinations. METHODS: The subjects were 91 outpatients with dementia...
April 4, 2017: Psychogeriatrics: the Official Journal of the Japanese Psychogeriatric Society
https://www.readbyqxmd.com/read/28351924/plasmodium-falciparum-maf1-confers-survival-upon-amino-acid-starvation
#7
Kyle Jarrod McLean, Marcelo Jacobs-Lorena
The target of rapamycin complex 1 (TORC1) pathway is a highly conserved signaling pathway across eukaryotes that integrates nutrient and stress signals to regulate the cellular growth rate and the transition into and maintenance of dormancy. The majority of the pathway's components, including the central TOR kinase, have been lost in the apicomplexan lineage, and it is unknown how these organisms detect and respond to nutrient starvation in its absence. Plasmodium falciparum encodes a putative ortholog of the RNA polymerase (Pol) III repressor Maf1, which has been demonstrated to modulate Pol III transcription in a TOR-dependent manner in a number of organisms...
March 28, 2017: MBio
https://www.readbyqxmd.com/read/28350412/effectiveness-of-a-structured-sexual-rehabilitation-programme-following-stroke-a-randomized-controlled-trial
#8
Louisa Ng, Joshua Sansom, Nina Zhang, Bhasker Amatya, Fary Khan
BACKGROUND: Sexual activity is an integral part of life; it is important to address sexual health after stroke, but this is often poorly done. OBJECTIVE: To assess the effectiveness of a structured sexual rehabilitation programme compared with written information alone regarding sexual and psychological functioning (anxiety, depression, stress), functional independence and quality of life in an Australian stroke cohort. METHODS: A total of 68 participants were randomized to a structured sexual rehabilitation programme (treatment group; n = 35) or to written information alone (control group; n = 33)...
April 6, 2017: Journal of Rehabilitation Medicine
https://www.readbyqxmd.com/read/28326341/cdc42-is-crucial-for-facial-and-palatal-formation-during-craniofacial-development
#9
Mutsuko Oshima-Nakayama, Atsushi Yamada, Tamaki Kurosawa, Ryo Aizawa, Dai Suzuki, Yoshiro Saito, Hidetoshi Kassai, Yuki Sato, Matsuo Yamamoto, Tatsuo Shirota, Atsu Aiba, Koutaro Maki, Ryutaro Kamijo
Craniofacial deformities with multifactorial etiologies, such as cleft palate and facial dysmorphism, represent some of the most frequent congenital birth defects seen in humans. Their pathogeneses are often related to cranial neural crest (CNC) cells. During CNC cell migration, changes in cell shape and formation, as well as maintenance of subcellular structures, such as filopodia and lamellipodia, are dependent on the complex functions of Rho family small GTPases, which are regulators of actin cytoskeletal organization...
December 2016: Bone Reports
https://www.readbyqxmd.com/read/28320963/conformational-dynamics-and-role-of-the-acidic-pocket-in-asic-ph-dependent-gating
#10
Sabrina Vullo, Gaetano Bonifacio, Sophie Roy, Niklaus Johner, Simon Bernèche, Stephan Kellenberger
Acid-sensing ion channels (ASICs) are proton-activated Na(+) channels expressed in the nervous system, where they are involved in learning, fear behaviors, neurodegeneration, and pain sensation. In this work, we study the role in pH sensing of two regions of the ectodomain enriched in acidic residues: the acidic pocket, which faces the outside of the protein and is the binding site of several animal toxins, and the palm, a central channel domain. Using voltage clamp fluorometry, we find that the acidic pocket undergoes conformational changes during both activation and desensitization...
April 4, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28299271/three-dimensional-printer-assisted-reduction-genioplasty-surgical-guide-fabrication
#11
Seied Omid Keyhan, Alireza Jahangirnia, Hamid Reza Fallahi, Alireza Navabazam, Sina Ghanean
Genioplasty is a common operation to enhance function and appearance of the chin, the most prominent part of the lower third of the face, which has major impact on character impressions and facial beauty. However, since transference of preconfigured accurate treatment plans to patients during operation is difficult, sometimes it can be challenging, especially for inexperienced surgeons. This article represents a simplified technique to perform reduction genioplasty by utilizing a customized genioplasty guide manufactured with three-dimensional printing technology...
July 2016: Annals of Maxillofacial Surgery
https://www.readbyqxmd.com/read/28285177/love-me-tinder-body-image-and-psychosocial-functioning-among-men-and-women
#12
Jessica Strubel, Trent A Petrie
Based on objectification theory, we examined the main effects of Tinder use, and its interaction with gender, in relation to men's and women's body image concerns, internalization processes, and self-esteem. Tinder users (men=31; women=69) and non-users (men=203; women=844) anonymously completed measures via an online survey. Through a series of ANCOVAs, with BMI and age as covariates, Tinder users, regardless of gender, reported significantly lower levels of satisfaction with face and body and higher levels of internalization, appearance comparisons, and body shame and surveillance than non-users...
March 8, 2017: Body Image
https://www.readbyqxmd.com/read/28284488/agnosic-vision-is-like-peripheral-vision-which-is-limited-by-crowding
#13
Francesca Strappini, Denis G Pelli, Enrico Di Pace, Marialuisa Martelli
Visual agnosia is a neuropsychological impairment of visual object recognition despite near-normal acuity and visual fields. A century of research has provided only a rudimentary account of the functional damage underlying this deficit. We find that the object-recognition ability of agnosic patients viewing an object directly is like that of normally-sighted observers viewing it indirectly, with peripheral vision. Thus, agnosic vision is like peripheral vision. We obtained 14 visual-object-recognition tests that are commonly used for diagnosis of visual agnosia...
February 1, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28282414/cognitive-control-attention-and-the-other-race-effect-in-memory
#14
Thackery I Brown, Melina R Uncapher, Tiffany E Chow, Jennifer L Eberhardt, Anthony D Wagner
People are better at remembering faces from their own race than other races-a phenomenon with significant societal implications. This Other Race Effect (ORE) in memory could arise from different attentional allocation to, and cognitive control over, same- and other-race faces during encoding. Deeper or more differentiated processing of same-race faces could yield more robust representations of same- vs. other-race faces that could support better recognition memory. Conversely, to the extent that other-race faces may be characterized by lower perceptual expertise, attention and cognitive control may be more important for successful encoding of robust, distinct representations of these stimuli...
2017: PloS One
https://www.readbyqxmd.com/read/28279397/-reconstruction-of-the-ear-in-the-burns-patient
#15
Jorge Raúl Carrillo-Córdova, Yusef Jiménez Murat, Armando Apellaniz-Campo, Hazel Bracho-Olvera, Raúl Carrillo Esper
Face burns are a singular pathology with great functional and psychological impact in the patients suffering them. The ears play a fundamental role in personal interactions and damage to this organ results in physical and emotional distress. The reconstructive treatment of the burned ear is a challenge. Multiple procedures have been described to achieve success in the reconstruction of the burned ear; immediate reconstruction with autologous rib cartilage, secondary reconstruction, alloplastic material reconstruction, tissue expansion, skin grafts and also microvascular flaps are some of the most common procedures used in this patients...
March 6, 2017: Cirugia y Cirujanos
https://www.readbyqxmd.com/read/28241792/genome-content-analysis-yields-new-insights-into-the-relationship-between-the-human-malaria-parasite-plasmodium-falciparum-and-its-anopheline-vectors
#16
Sara J Oppenheim, Jeffrey A Rosenfeld, Rob DeSalle
BACKGROUND: The persistent and growing gap between the availability of sequenced genomes and the ability to assign functions to sequenced genes led us to explore ways to maximize the information content of automated annotation for studies of anopheline mosquitos. Specifically, we use genome content analysis of a large number of previously sequenced anopheline mosquitos to follow the loss and gain of protein families over the evolutionary history of this group. The importance of this endeavor lies in the potential for comparative genomic studies between Anopheles and closely related non-vector species to reveal ancestral genome content dynamics involved in vector competence...
February 27, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28216810/nasal-correction-in-nasomaxillary-hypoplasia-binder-s-syndrome-an-optimised-classification-and-treatment
#17
Venkata Ramana Yamani, Shakuntala Ghosh, Shreekumar Tirunagari
BACKGROUND: Nasomaxillary hypoplasia is a rare congenital disorder involving the central face. It imparts a distinctive appearance to the individual face as the age advances. Severity of the disorder varies, so do the manifestations. METHODS: This was a retrospective study conducted on the records and photographic data of 560 rhinoplasty cases performed between 2006 March and 2016 March. About 16 cases of nasomaxillary hypoplasia were selected from the group and they were classified based on the severity of the features...
September 2016: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
https://www.readbyqxmd.com/read/28209907/equivalent-dose-rate-at-1m-of-patients-with-known-or-suspected-neuroendocrine-tumor-exiting-a-nuclear-medicine-department-after-68-ga-dotatoc-18-f-fdopa-or-18-f-fdg-pet-ct-or-111-in-pentetreotide-or-123-i-mibg-spect-ct
#18
Jules Zhang-Yin, Anne-Sophie Dirand, Myriam Sasanelli, Gwenaelle Corrégé, Aude Peudon, Thierry Kiffel, Valérie Nataf, Jérôme Clerc, Françoise Montravers, Jean-Noël Talbot
(123)I-mIBG and (111)In-pentetrotide SPECT have been used for functional imaging of neuroendocrine tumors (NET) for the last two decades. More recently, PET/CT imaging with (18)F-FDG, (18)F-FDOPA and (68)Ga somatostatin-receptor ligands in NETs has been expanding. No direct measurements of the dose rate from NET patients exiting the nuclear medicine department could be found in the literature after PET/CT with (18)F-FDOPA or (68)Ga-DOTATOC, a somatostatin analogue. Methods: We measured the dose rates from NET patients undergoing PET/CT or SPECT/CT in our centers...
February 16, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28202765/the-lateral-organization-of-influenza-virus-proteins-in-the-budozone-region-of-the-plasma-membrane
#19
George P Leser, Robert A Lamb
Influenza virus assembles and buds at the plasma membrane of virus-infected cells. The viral proteins assemble at the same site on the plasma membrane for budding to occur. This involves a complex web of interactions among viral proteins. Some, like HA, NA, and M2 are integral membrane proteins. M1 is peripherally membrane associated, whereas NP associates with the viral RNA to form an RNP complex that associates with the cytoplasmic face of the plasma membrane. Furthermore, HA and NP have been shown to be concentrated in cholesterol-rich membrane raft domains whereas M2, although containing a cholesterol binding motif, is not raft associated...
February 15, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28194640/life-beyond-a-diagnosis-of-glioblastoma-a-systematic-review-of-the-literature
#20
REVIEW
L Gately, S A McLachlan, A Dowling, J Philip
BACKGROUND: The median survival of glioblastoma is 12-14 months with less than 10% of patients surviving at least 2 years from diagnosis. Patients diagnosed with glioblastoma face poor prognosis, significant symptom burden, and high care needs. The aim of this study is to undertake a literature review to document the issues encountered by long-term survivors of glioblastoma, a small but important subset of patients. METHODS: MEDLINE, PsychInfo, and EMBASE were searched with core concepts: (1) glioblastoma, (2) survivor, and (3) terms pertaining to survivorship issues...
February 13, 2017: Journal of Cancer Survivorship: Research and Practice
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