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appearance is a function of face

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https://www.readbyqxmd.com/read/29437508/what-matters-to-patients-with-cleft-lip-and-or-palate-an-international-qualitative-study-informing-the-development-of-the-cleft-q
#1
Karen W Y Wong Riff, Elena Tsangaris, Timothy E E Goodacre, Christopher R Forrest, Jessica Lawson, Andrea L Pusic, Anne F Klassen
OBJECTIVE: The goal of treatment for individuals with cleft lip and/or palate (CL/P) is to improve physical, psychological, and social health. Outcomes of treatment are rarely measured from the patient's perspective. The aim of the study was to develop a conceptual framework for a patient-reported outcome (PRO) instrument for individuals with clefts (CLEFT-Q) by developing an in-depth understanding of issues that individuals consider to be important. DESIGN: The qualitative methodology of interpretive description was used...
March 2018: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/29430228/routine-treatment-resistant-clostridium-difficile-infection-during-recovery-from-myxedema
#2
Jan K Adamski, Björn B Jäschke, Raija S Uusitalo-Seppälä, Kalle V J Moilanen, Antti V Pehkonen, Wojciech Weigl
Development of the extreme form of hypothyroidism defined as myxedema is very rare. Acute symptoms and their management have been described in detail previously. However, not much attention has been devoted to therapeutic challenges that are faced in the recovery phase of the treatment, especially pertaining to the gastrointestinal system. The link between myxedema and the appearance of severe Clostridium difficile infection (CDI) has not been established so far. A 61-year-old woman with no significant medical record was admitted to hospital because of infected heel pressure and thyroid dysfunction...
September 2017: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/29419811/plant-and-mammal-aquaporins-same-but-different
#3
REVIEW
Timothée Laloux, Bruna Junqueira, Laurie C Maistriaux, Jahed Ahmed, Agnieszka Jurkiewicz, François Chaumont
Aquaporins (AQPs) constitute an ancient and diverse protein family present in all living organisms, indicating a common ancient ancestor. However, during evolution, these organisms appear and evolve differently, leading to different cell organizations and physiological processes. Amongst the eukaryotes, an important distinction between plants and animals is evident, the most conspicuous difference being that plants are sessile organisms facing ever-changing environmental conditions. In addition, plants are mostly autotrophic, being able to synthesize carbohydrates molecules from the carbon dioxide in the air during the process of photosynthesis, using sunlight as an energy source...
February 8, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29398222/analysis-of-evolutionarily-independent-protein-rna-complexes-yields-a-criterion-to-evaluate-the-relevance-of-prebiotic-scenarios
#4
Celia Blanco, Marco Bayas, Fu Yan, Irene A Chen
A central difficulty facing study of the origin of life on Earth is evaluating the relevance of different proposed prebiotic scenarios. Perhaps the most established feature of the origin of life was the progression through an RNA World, a prebiotic stage dominated by functional RNA. We use the appearance of proteins in the RNA World to understand the prebiotic milieu and develop a criterion to evaluate proposed synthetic scenarios. Current consensus suggests that the earliest amino acids of the genetic code were anionic or small hydrophobic or polar amino acids...
January 29, 2018: Current Biology: CB
https://www.readbyqxmd.com/read/29394332/beyond-the-face-how-context-modulates-emotion-processing-in-frontotemporal-dementia-subtypes
#5
Fiona Kumfor, Agustin Ibañez, Rosalind Hutchings, Jessica L Hazelton, John R Hodges, Olivier Piguet
The importance of assessing social cognition to characterize dementia syndromes is increasingly recognized, with lower social cognition capacity associated with reduced functional independence and greater carer burden. Emotion recognition is impaired in both behavioural-variant frontotemporal dementia and semantic dementia, yet the social and behavioural changes observed in these syndromes in everyday situations varies. To date, most studies have investigated isolated, context-free stimuli indexing recognition of facial emotions only...
January 31, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29377992/genetic-and-epigenetic-factors-which-modulate-differentiation-propensity-in-human-pluripotent-stem-cells
#6
Alexander Keller, Dominika Dziedzicka, Filippo Zambelli, Christina Markouli, Karen Sermon, Claudia Spits, Mieke Geens
BACKGROUND: Human pluripotent stem cell (hPSC) lines are known to have a bias in their differentiation. This gives individual cell lines a propensity to preferentially differentiate towards one germ layer or cell type over others. Chromosomal aberrations, mitochondrial mutations, genetic diversity and epigenetic variance are the main drivers of this phenomenon, and can lead to a wide range of phenotypes. OBJECTIVE AND RATIONALE: Our aim is to provide a comprehensive overview of the different factors which influence differentiation propensity...
January 25, 2018: Human Reproduction Update
https://www.readbyqxmd.com/read/29349052/malar-relocation-with-reverse-l-osteotomy-and-autogenous-bone-graft
#7
Se Hoon Yoon, Euicheol Jeong, Jee Hyeok Chung
The zygomaticomaxillary complex (ZMC) functions as a buttress for the face and is the cornerstone to a person's aesthetic appearance, by both setting the midfacial width and providing prominence to the cheek. Malar deficiency is often acquired by blunt injury incurred in a traumatic accident, resulting in ZMC fracture. A 48-year-old male patient presented a right ZMC fracture after contusion injury by a baseball. He only received conservative management and later he suffered discomfort during mouth opening at the moment of mastication, due to trismus involving the temporomandibular joint...
December 2017: Archives of Craniofacial Surgery
https://www.readbyqxmd.com/read/29346985/three-faces-of-entropy-for-complex-systems-information-thermodynamics-and-the-maximum-entropy-principle
#8
Stefan Thurner, Bernat Corominas-Murtra, Rudolf Hanel
There are at least three distinct ways to conceptualize entropy: entropy as an extensive thermodynamic quantity of physical systems (Clausius, Boltzmann, Gibbs), entropy as a measure for information production of ergodic sources (Shannon), and entropy as a means for statistical inference on multinomial processes (Jaynes maximum entropy principle). Even though these notions represent fundamentally different concepts, the functional form of the entropy for thermodynamic systems in equilibrium, for ergodic sources in information theory, and for independent sampling processes in statistical systems, is degenerate, H(p)=-∑_{i}p_{i}logp_{i}...
September 2017: Physical Review. E
https://www.readbyqxmd.com/read/29339309/late-chronotype-is-associated-with-enhanced-amygdala-reactivity-and-reduced-fronto-limbic-functional-connectivity-to-fearful-versus-happy-facial-expressions
#9
Charlotte Mary Horne, Ray Norbury
Increasing evidence suggests late chronotype individuals are at increased risk of developing depression. However, the underlying neural mechanisms that confer risk are not fully understood. Here, fifty healthy, right-handed individuals without a current or previous diagnosis of depression, family history of depression or sleep disorder underwent functional magnetic resonance imaging (FMRI). Participants completed an implicit emotion processing task (gender discrimination) including happy and fearful facial expressions...
January 12, 2018: NeuroImage
https://www.readbyqxmd.com/read/29317201/mutation-induced-changes-of-transmembrane-pore-size-revealed-by-combined-ion-channel-conductance-and-single-vesicle-permeabilization-analyses
#10
Eneko Largo, Douglas P Gladue, Johana Torralba, Vicente M Aguilella, Antonio Alcaraz, Manuel V Borca, José L Nieva
Permeabilization of the Endoplasmic Reticulum (ER) is instrumental in the progression of host-cell infection by many viral pathogens. We have described that permeabilization of ER model membranes by the pore-forming domain of the Classical Swine Fever Virus (CSFV) p7 protein depends on two sequence determinants: the C-terminal transmembrane helix, and the preceding polar loop that regulates its activity. Here, by combining ion-channel activity measurements in planar lipid bilayers with imaging of single Giant Unilamellar Vesicles (GUVs), we demonstrate that point substitutions directed to conserved residues within these regions affect ER-like membrane permeabilization following distinct mechanisms...
January 6, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29298934/evolutionary-and-structural-analyses-uncover-a-role-for-solvent-interactions-in-the-diversification-of-cocoonases-in-butterflies
#11
G Smith, J E Kelly, A Macias-Muñoz, C T Butts, R W Martin, A D Briscoe
Multi-omic approaches promise to supply the power to detect genes underlying disease and fitness-related phenotypes. Optimal use of the resulting profusion of data requires detailed investigation of individual candidate genes, a challenging proposition. Here, we combine transcriptomic and genomic data with molecular modelling of candidate enzymes to characterize the evolutionary history and function of the serine protease cocoonase. Heliconius butterflies possess the unique ability to feed on pollen; recent work has identified cocoonase as a candidate gene in pollen digestion...
January 10, 2018: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/29274378/sources-of-maladaptive-behavior-in-normal-organisms
#12
REVIEW
Ralph R Miller, Cody W Polack
A basic assumption of most researchers is that behavior is generally functional, and indeed, in most instances the function is obvious. But in a number of cases, some behaviors of neurophysiologically 'normal' organisms appear to be maladaptive. Considerable research has been conducted to understand the basis of such behavior as well as how the frequency of such behavior can be reduced. Here we provide a brief panoramic review of the major sources of maladaptive behavior in neurophysiologically 'normal' organisms: a) altered environmental contingencies relative to those faced by ancestral generations in their environment of evolutionary adaptation, b) altered environmental contingencies within the lifespan of the animal, c) linked behaviors in which the dysfunctional behavior is a linked companion of a more valuable beneficial trait, and d) the labeling of some behaviors as 'maladaptive' when more careful examination finds that they provide net benefit...
December 20, 2017: Behavioural Processes
https://www.readbyqxmd.com/read/29273685/igf-i-receptor-and-thyroid-associated-ophthalmopathy
#13
Michelle Mohyi, Terry J Smith
Thyroid-associated ophthalmopathy (TAO) is a vexing and poorly understood autoimmune process involving the upper face and tissues surrounding the eyes. In TAO, the orbit can become inflamed and undergo substantial remodeling that is disfiguring and can lead to loss of vision. These are currently no approved medical therapies for TAO, the consequence of its uncertain pathogenic nature. It usually presents as a component of the syndrome known as Graves' disease where loss of immune tolerance to the thyrotropin receptor (TSHR) results in the generation of activating antibodies against that protein and hyperthyroidism...
December 22, 2017: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/29261517/treatment-approach-to-severe-microgenia-cases-combined-use-of-osseous-and-implant-genioplasty
#14
Kemal Findikcioglu, Serhat Sibar, Ayse Gulsen
INTRODUCTION: As well as the chin is an important esthetic unit of the facial structure, it is also the region having a key role in the appearance of the face. Correction of cosmetic and functional deformities that may occur in this region because of serious hypoplasia (microgenia) is performed by chin augmentation. Chin augmentation is most frequently performed via implant or osseous genioplasty in the literature. Both 2 techniques have their own advantages and disadvantages. In the literature, various studies comparing these 2 techniques and their long-term results are present, but in some severe microgenia cases, these techniques can be insufficient only for augmentation...
December 19, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29248472/evolution-and-development-of-the-cartilaginous-skull-from-a-lancelet-towards-a-human-face
#15
REVIEW
Marketa Kaucka, Igor Adameyko
Chrondrocranium, the cartilaginous skull, is one of the major innovations that underlie evolution of the vertebrate head. Control of the induction and shaping of the cartilage is a key for the formation of the facial bones and largely defines facial shape. The appearance of cartilage in the head enabled many new functions such as protection of central nervous system and sensory structures, support of the feeding apparatus and formation of muscle attachment points ensuring faster and coordinated jaw movements...
December 13, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/29232710/stabilizing-patterns-in-time-neural-network-approach
#16
Nadav Ben-Shushan, Misha Tsodyks
Recurrent and feedback networks are capable of holding dynamic memories. Nonetheless, training a network for that task is challenging. In order to do so, one should face non-linear propagation of errors in the system. Small deviations from the desired dynamics due to error or inherent noise might have a dramatic effect in the future. A method to cope with these difficulties is thus needed. In this work we focus on recurrent networks with linear activation functions and binary output unit. We characterize its ability to reproduce a temporal sequence of actions over its output unit...
December 12, 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/29212052/biotic-diversity-of-benthic-macroinvertebrates-at-contrasting-glacier-fed-systems-in-patagonia-mountains-the-role-of-environmental-heterogeneity-facing-global-warming
#17
María Laura Miserendino, Cecilia Brand, Luis B Epele, Cecilia Y Di Prinzio, Guillermo H Omad, Miguel Archangelsky, Oscar Martínez, Adriana M Kutschker
Patagonia is by far the largest glacierized area in South America. However, little is known about ecology, functioning and biodiversity of glacier-fed streams facing global warming. We investigated changes in environmental features and macroinvertebrate communities along a longitudinal gradient of glacier influence of two Patagonian systems that differ in glacier cover magnitude and the spatial sequence of lotic and lentic phases. Both glaciers, Torrecillas (~5.5km2, Torrecillas system) and Cónico (~0.44km2, Baggilt system), are retreating...
December 3, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29197102/evaluation-of-a-computerized-cognitive-behavioural-therapy-programme-mindwise-2-0-for-adults-with-mild-to-moderate-depression-and-anxiety
#18
Sarah Collins, Michael Byrne, James Hawe, Gary O'Reilly
OBJECTIVES: To investigate the acceptability and utility of a newly developed computerized cognitive behavioural therapy (cCBT) programme, MindWise (2.0), for adults attending Irish primary care psychology services. METHOD: Adult primary care psychology service users across four rural locations in Ireland were invited to participate in this study. A total of 60 service users participated in the MindWise (2.0) treatment group and compared to 22 people in a comparison waiting list control group...
December 2, 2017: British Journal of Clinical Psychology
https://www.readbyqxmd.com/read/29194849/somatotopic-effects-of-rtms-in-neuropathic-pain-a-comparison-between-stimulation-over-hand-and-face-motor-areas
#19
N Andre-Obadia, M Magnin, E Simon, L Garcia-Larrea
BACKGROUND: The therapeutic influence of somatotopic matching between pain topography and motor cortex stimulation site for neuropathic pain (NP) remains controversial. METHODS: Thirty-two patients suffering from NP involving the upper limb (n = 20) or the face (n = 12) received two high-frequency rTMS neuronavigated sessions targeting hand and face motor cortical areas, versus placebo. The cortical target was defined by anatomical MRI and EMG responses in all patients, completed in 19 of them by functional MRI...
December 1, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29192872/experience-of-being-young-with-psoriasis-self-management-support-needs
#20
Gitte Susanne Rasmussen, Knud Kragballe, Helle Terkildsen Maindal, Kirsten Lomborg
Psoriasis is a long-term condition with a possibly cumulative life course impairment. Young people struggle to minimize its effects on appearance and functioning. To date, the self-management needs of adolescents suffering from psoriasis have been underinvestigated. Using focus groups and individual interviews, we present an interpretive description of young people's experiences of living with psoriasis, the challenges they face, and the support they need to relieve suffering and come to terms with their condition...
January 2018: Qualitative Health Research
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