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https://www.readbyqxmd.com/read/28522226/electron-crystallography-reveals-that-substrate-release-from-the-pts-iic-glucose-transporter-is-coupled-to-a-subtle-conformational-change
#1
David Kalbermatter, Po-Lin Chiu, Jean-Marc Jeckelmann, Zöhre Ucurum, Thomas Walz, Dimitrios Fotiadis
The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS) is a structurally and functionally complex system that mediates sugar uptake in bacteria. Besides several soluble subunits, the glucose-specific PTS includes the integral membrane protein IICB that couples the transmembrane transport of glucose to its phosphorylation. Here, we used electron crystallography of sugar-embedded tubular crystals of the glucose-specific IIC transport domain from Escherichia coli (ecIIC(glc)) to visualize the structure of the transporter in the presence and absence of its substrate...
May 15, 2017: Journal of Structural Biology
https://www.readbyqxmd.com/read/28507055/adhesion-and-friction-of-the-smooth-attachment-system-of-the-cockroach-gromphadorhina-portentosa-and-the-influence-of-the-application-of-fluid-adhesives
#2
Oliver Betz, Melina Frenzel, Michael Steiner, Martin Vogt, Malte Kleemeier, Andreas Hartwig, Benjamin Sampalla, Frank Rupp, Moritz Boley, Christian Schmitt
Two different measurement techniques were applied to study the attachment of the smooth foot pads of the Madagascar hissing cockroach Gromphadorhina portentosa The attachment of the non-manipulated adhesive organs was compared with that of manipulated ones (depletion or substitution by artificial secretions). From measurements of the friction on a centrifuge, it can be concluded that on nanorough surfaces, the insect appears to benefit from employing emulsions instead of pure oils to avoid excessive friction...
May 15, 2017: Biology Open
https://www.readbyqxmd.com/read/28495886/the-sigma-1-receptor-modulates-dopamine-transporter-conformation-and-cocaine-binding-and-may-thereby-potentiate-cocaine-self-administration-in-rats
#3
Weimin Conrad Hong, Hideaki Yano, Takato Hiranita, Frederick T Chin, Christopher R McCurdy, Tsung-Ping Su, Susan G Amara, Jonathan L Katz
The dopamine transporter (DAT) regulates dopamine (DA) neurotransmission by recapturing DA into the presynaptic terminals, and is a principal target of the psychostimulant cocaine. The sigma-1 receptor (σ1R) is a molecular chaperone, and its ligands have been shown to modulate dopamine neuronal signaling, although their effects on DAT activity are unclear. Here, we report that the prototypical σ1R agonist (+)-pentazocine potentiated the dose response of cocaine self-administration in rats, consistent with effects of the σR agonists PRE-084 and DTG reported previously...
May 11, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28473796/priming-the-secure-attachment-schema-affects-the-emotional-face-processing-bias-in-attachment-anxiety-an-fmri-research
#4
Qingting Tang, Xu Chen, Jia Hu, Ying Liu
Our study explored how priming with a secure base schema affects the processing of emotional facial stimuli in individuals with attachment anxiety. We enrolled 42 undergraduate students between 18 and 27 years of age, and divided them into two groups: attachment anxiety and attachment secure. All participants were primed under two conditions, the secure priming using references to the partner, and neutral priming using neutral references. We performed repeated attachment security priming combined with a dual-task paradigm and functional magnetic resonance imaging...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28470821/the-effects-of-early-institutionalization-on-emotional-face-processing-evidence-for-sparing-via-an-experience-dependent-mechanism
#5
Audrey Young, Rhiannon J Luyster, Nathan A Fox, Charles H Zeanah, Charles A Nelson
Early psychosocial deprivation has profound adverse effects on children's brain and behavioural development, including abnormalities in physical growth, intellectual function, social cognition, and emotional development. Nevertheless, the domain of emotional face processing has appeared in previous research to be relatively spared; here, we test for possible sleeper effects emerging in early adolescence. This study employed event-related potentials (ERPs) to examine the neural correlates of facial emotion processing in 12-year-old children who took part in a randomized controlled trial of foster care as an intervention for early institutionalization...
May 4, 2017: British Journal of Developmental Psychology
https://www.readbyqxmd.com/read/28459684/towards-robust-and-accurate-multi-view-and-partially-occluded-face-alignment
#6
Junliang Xing, Zhiheng Niu, Junshi Huang, Weiming Hu, Xi Zhou, Shuicheng Yan
Face alignment acts as an important task in computer vision. Regression-based methods currently dominate the approach to solving this problem, which generally employ a series of mapping functions from the face appearance to iteratively update the face shape hypothesis. One keypoint here is thus how to perform the regression procedure. In this work, we formulate this regression procedure as a sparse coding problem. We learn two relational dictionaries, one for the face appearance and the other one for the face shape, with coupled reconstruction coefficient to capture their underlying relationships...
April 25, 2017: IEEE Transactions on Pattern Analysis and Machine Intelligence
https://www.readbyqxmd.com/read/28451634/position-information-encoded-by-population-activity-in-hierarchical-visual-areas
#7
Kei Majima, Paul Sukhanov, Tomoyasu Horikawa, Yukiyasu Kamitani
Neurons in high-level visual areas respond to more complex visual features with broader receptive fields (RFs) compared to those in low-level visual areas. Thus, high-level visual areas are generally considered to carry less information regarding the position of seen objects in the visual field. However, larger RFs may not imply loss of position information at the population level. Here, we evaluated how accurately the position of a seen object could be predicted (decoded) from activity patterns in each of six representative visual areas with different RF sizes [V1-V4, lateral occipital complex (LOC), and fusiform face area (FFA)]...
March 2017: ENeuro
https://www.readbyqxmd.com/read/28445228/the-relationship-of-core-strength-and-activation-and-performance-on-three-functional-movement-screens
#8
Caleb D Johnson, Paul N Whitehead, Erin R Pletcher, Mallory S Faherty, Mita T Lovaleka, Shawn R Eagle, Karen A Keenan
Current measures of core stability utilized by clinicians and researchers suffer from several shortcomings. Three functional movement screens appear, at face-value, to be dependent on the ability to activate and control core musculature. These three screens may present a viable alternative to current measures of core stability. Thirty-nine subjects completed a deep squat, trunk stability push-up, and rotary stability screen. Scores on the three screens were summed to calculate a composite score (COMP). During the screens, muscle activity was collected to determine the length of time that the bilateral erector spinae, rectus abdominus, external oblique, and gluteus medius muscles were active...
April 18, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28439797/desmoid-type-fibromatosis-who-when-and-how-to-treat
#9
REVIEW
Javier Martínez Trufero, Isabel Pajares Bernad, Irene Torres Ramón, Jorge Hernando Cubero, Roberto Pazo Cid
Desmoid-type fibromatosis is a sarcoma subtype that gathers some singular characteristics, making it a difficult challenge to face in clinical practice. Despite its excellent survival prognosis, these tumors may be unpredictable, ranging from an asymptomatic indolent course to persistent, local, and extended recurrences that significantly impair quality of life. Although surgery was initially considered the first elective treatment, collected published data during the past few years are now pointing to the "wait and see" approach as a reasonable initial strategy because many patients can live a long life with the disease without having symptoms...
May 2017: Current Treatment Options in Oncology
https://www.readbyqxmd.com/read/28433401/relaxed-open-mouth-reciprocity-favours-playful-contacts-in-south-american-sea-lions-otaria-flavescens
#10
Clara Llamazares-Martín, Chiara Scopa, Federico Guillén-Salazar, Elisabetta Palagi
Fine-tuning communication is well documented in mammalian social play which relies on a large variety of specific and non-specific signals. Facial expressions are one of the most frequent patterns in play communication. The reciprocity of facial signals expressed by the players provides information on their reciprocal attentional state and on the correct perception/decoding of the signal itself. Here, for the first time, we explored the Relaxed Open Mouth (ROM), a widespread playful facial expression among mammals, in the South American sea lion (Otaria flavescens)...
April 20, 2017: Behavioural Processes
https://www.readbyqxmd.com/read/28431666/glp-1-receptor-agonists-and-heart-failure-in-diabetes
#11
André J Scheen
The prevalence of heart failure (HF) is increasing in patients with type 2 diabetes (T2D), and glucose-lowering agents have distinctive effects on the risk of developing HF that requires hospitalization. Such an increased risk has been consistently reported with thiazolidinediones (glitazones) and perhaps also with the dipeptidyl peptidase (DPP)-4 inhibitor saxagliptin (at least in SAVOR - TIMI 53), whereas a markedly decreased risk was highlighted with the sodium - glucose cotransporter type 2 (SGLT2) inhibitor empagliflozin in EMPA-REG OUTCOME...
April 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28411271/neural-correlates-of-semantic-prediction-and-resolution-in-sentence-processing
#12
Luigi Grisoni, Tally McCormick Miller, Friedemann Pulvermüller
Most brain-imaging studies of language comprehension focus on activity following meaningful stimuli. Testing adult human participants with high-density EEG, we show that, already before the presentation of a critical word, context-induced semantic predictions are reflected by a neurophysiological index, which we therefore call the semantic readiness potential (SRP). The SRP precedes critical words if a previous sentence context constrains the upcoming semantic content (high-constraint contexts), but not in unpredictable (low-constraint) contexts...
May 3, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28410650/prehabilitation-for-the-frail-patient-approaching-esrd
#13
REVIEW
Anoop Sheshadri, Kirsten L Johansen
Frailty is a distinct phenotype that is highly prevalent in chronic kidney disease (CKD) and appears to be more prevalent with decreasing glomerular filtration rate. Exercise training or intervention to increase physical activity may ameliorate poor physical functioning and frailty, and even may improve survival in patients with CKD. Although exercise interventions improve outcomes across the spectrum of CKD, including patients treated with dialysis, patients treated with dialysis face barriers to exercise that patients with predialysis CKD do not...
March 2017: Seminars in Nephrology
https://www.readbyqxmd.com/read/28406382/reading-what-the-mind-thinks-from-how-the-eye-sees
#14
Daniel H Lee, Adam K Anderson
Human eyes convey a remarkable variety of complex social and emotional information. However, it is unknown which physical eye features convey mental states and how that came about. In the current experiments, we tested the hypothesis that the receiver's perception of mental states is grounded in expressive eye appearance that serves an optical function for the sender. Specifically, opposing features of eye widening versus eye narrowing that regulate sensitivity versus discrimination not only conveyed their associated basic emotions (e...
April 2017: Psychological Science
https://www.readbyqxmd.com/read/28395026/the-structural-role-of-elastic-fibers-in-the-cornea-investigated-using-a-mouse-model-for-marfan-syndrome
#15
Tomas L White, Philip Lewis, Sally Hayes, James Fergusson, James Bell, Luis Farinha, Nick S White, Lygia V Pereira, Keith M Meek
Purpose: The presence of fibrillin-rich elastic fibers in the cornea has been overlooked in recent years. The aim of the current study was to elucidate their functional role using a mouse model for Marfan syndrome, defective in fibrillin-1, the major structural component of the microfibril bundles that constitute most of the elastic fibers. Methods: Mouse corneas were obtained from animals with a heterozygous fibrillin-1 mutation (Fbn1+/-) and compared to wild type controls...
April 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28384543/novel-organophosphorus-scaffolds-of-urease-inhibitors-obtained-by-substitution-of-morita-baylis-hillman-adducts-with-phosphorus-nucleophiles
#16
Vassilis Ntatsopoulos, Stamatia Vassiliou, Katarzyna Macegoniuk, Łukasz Berlicki, Artur Mucha
The reactivity of Morita-Baylis-Hillman allyl acetates was employed to introduce phosphorus-containing functionalities to the side chain of the cinnamic acid conjugated system by nucleophilic displacement. The proximity of two acidic groups, the carboxylate and phosphonate/phosphinate groups, was necessary to form interactions in the active site of urease by recently described inhibitor frameworks. Several organophosphorus scaffolds were obtained and screened for inhibition of the bacterial urease, an enzyme that is essential for survival of urinary and gastrointestinal tract pathogens...
March 29, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28378386/why-do-people-with-dementia-pretend-to-know-the-correct-answer-a-qualitative-study-on-the-behaviour-of-toritsukuroi-to-keep-up-appearances
#17
Masateru Matsushita, Yusuke Yatabe, Asuka Koyama, Yukiko Ueno, Daisuke Ijichi, Hiroto Ikezaki, Mamoru Hashimoto, Noboru Furukawa, Manabu Ikeda
BACKGROUND: Toritsukuroi is a particular type of behaviour intended to save face or preserve appearances. Clinicians often observe toritsukuroi in people with dementia, but current knowledge about this behaviour is based on clinicians' empirical knowledge rather than on observational studies. This study was designed to clarify which behaviours are related to toritsukuroi based on neuropsychological examinations. METHODS: The subjects were 91 outpatients with dementia...
April 4, 2017: Psychogeriatrics: the Official Journal of the Japanese Psychogeriatric Society
https://www.readbyqxmd.com/read/28351924/plasmodium-falciparum-maf1-confers-survival-upon-amino-acid-starvation
#18
Kyle Jarrod McLean, Marcelo Jacobs-Lorena
The target of rapamycin complex 1 (TORC1) pathway is a highly conserved signaling pathway across eukaryotes that integrates nutrient and stress signals to regulate the cellular growth rate and the transition into and maintenance of dormancy. The majority of the pathway's components, including the central TOR kinase, have been lost in the apicomplexan lineage, and it is unknown how these organisms detect and respond to nutrient starvation in its absence. Plasmodium falciparum encodes a putative ortholog of the RNA polymerase (Pol) III repressor Maf1, which has been demonstrated to modulate Pol III transcription in a TOR-dependent manner in a number of organisms...
March 28, 2017: MBio
https://www.readbyqxmd.com/read/28350412/effectiveness-of-a-structured-sexual-rehabilitation-programme-following-stroke-a-randomized-controlled-trial
#19
RANDOMIZED CONTROLLED TRIAL
Louisa Ng, Joshua Sansom, Nina Zhang, Bhasker Amatya, Fary Khan
BACKGROUND: Sexual activity is an integral part of life; it is important to address sexual health after stroke, but this is often poorly done. OBJECTIVE: To assess the effectiveness of a structured sexual rehabilitation programme compared with written information alone regarding sexual and psychological functioning (anxiety, depression, stress), functional independence and quality of life in an Australian stroke cohort. METHODS: A total of 68 participants were randomized to a structured sexual rehabilitation programme (treatment group; n = 35) or to written information alone (control group; n = 33)...
April 6, 2017: Journal of Rehabilitation Medicine
https://www.readbyqxmd.com/read/28326341/cdc42-is-crucial-for-facial-and-palatal-formation-during-craniofacial-development
#20
Mutsuko Oshima-Nakayama, Atsushi Yamada, Tamaki Kurosawa, Ryo Aizawa, Dai Suzuki, Yoshiro Saito, Hidetoshi Kassai, Yuki Sato, Matsuo Yamamoto, Tatsuo Shirota, Atsu Aiba, Koutaro Maki, Ryutaro Kamijo
Craniofacial deformities with multifactorial etiologies, such as cleft palate and facial dysmorphism, represent some of the most frequent congenital birth defects seen in humans. Their pathogeneses are often related to cranial neural crest (CNC) cells. During CNC cell migration, changes in cell shape and formation, as well as maintenance of subcellular structures, such as filopodia and lamellipodia, are dependent on the complex functions of Rho family small GTPases, which are regulators of actin cytoskeletal organization...
December 2016: Bone Reports
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