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https://www.readbyqxmd.com/read/27931764/accuracy-of-remote-burn-scar-evaluation-via-live-video-conferencing-technology
#1
Lawrence Z Cai, Maria Caceres, Mohan Krishna Dangol, Shankar Man Rai, James Chang, Nicole S Gibran, Tam N Pham
OBJECTIVE: Telemedicine in outpatient burn care, particularly in burn scar management, may provide cost-effective care and comes highly rated by patients. However, an effective scar scale using both video and photographic elements has not been validated. The purpose of this study is to test the reliability of the Patient and Observer Scar Assessment Scale (POSAS) using live video-conferencing. METHODS: A prospective study was conducted with individuals with healed burn scars in Kathmandu, Nepal...
December 5, 2016: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/27924030/using-predictive-specificity-to-determine-when-gene-set-analysis-is-biologically-meaningful
#2
Sara Ballouz, Paul Pavlidis, Jesse Gillis
Gene set analysis, which translates gene lists into enriched functions, is among the most common bioinformatic methods. Yet few would advocate taking the results at face value. Not only is there no agreement on the algorithms themselves, there is no agreement on how to benchmark them. In this paper, we evaluate the robustness and uniqueness of enrichment results as a means of assessing methods even where correctness is unknown. We show that heavily annotated ('multifunctional') genes are likely to appear in genomics study results and drive the generation of biologically non-specific enrichment results as well as highly fragile significances...
October 24, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27922961/costochondral-graft-in-young-children-with-hemifacial-microsomia
#3
Bin-Zhang Wu, Lian Ma, Yang Li, Shuo Chen, Biao Yi
Patients with severely hypoplastic mandibles usually require condylar reconstruction. This study aimed to describe costochondral graft (CCG) for condylar reconstruction and report subsequent outcomes of these grafts in young children with Pruzansky/Kaban type IIB and type III mandibular hypoplasia. This study included 4 young children with type IIB and type III hemifacial microsomia treated with CCG to reconstruct the condyle at the Department of Oral and Maxillofacial Surgery in our hospital from March 2008 to March 2014...
December 5, 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27922917/adherence-to-oral-administration-of-endocrine-treatment-in-patients-with-breast-cancer-a-qualitative-study
#4
Laura Iacorossi, Francesca Gambalunga, Alessandra Fabi, Diana Giannarelli, Anna Marchetti, Michela Piredda, Maria Grazia De Marinis
BACKGROUND: Breast cancer is the most common cancer in women in the world, and it is also the leading cause of cancer deaths among women. Nevertheless, breast cancer survival has increased as a result of improvements in early diagnosis and therapy, for example, oral endocrine therapy. Despite the importance of adherence to endocrine therapy, its trend appears complex and multidimensional and therefore has many loopholes and missing information. OBJECTIVE: The study aims to explore the experiences of adherence to endocrine therapy in women with breast cancer and their perceptions of the challenges they face in adhering to their medication prescribed...
December 5, 2016: Cancer Nursing
https://www.readbyqxmd.com/read/27917128/what-role-can-avatars-play-in-e-mental-health-interventions-exploring-new-models-of-client-therapist-interaction
#5
REVIEW
Imogen C Rehm, Emily Foenander, Klaire Wallace, Jo-Anne M Abbott, Michael Kyrios, Neil Thomas
In the burgeoning field of e-mental health interventions, avatars are increasingly being utilized to facilitate online communication between clients and therapists, and among peers. Avatars are digital self-representations, which enable individuals to interact with each other in computer-based virtual environments. In this narrative review, we examine the psychotherapeutic applications of avatars that have been investigated and trialed to date. Five key applications were identified (1) in the formation of online peer support communities; (2) replicating traditional modes of psychotherapy by using avatars as a vehicle to communicate within a wholly virtual environment; (3) using avatar technology to facilitate or augment face-to-face treatment; (4) as part of serious games; and (5) communication with an autonomous virtual therapist...
2016: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/27906082/secondary-correction-of-nasal-deformities-in-cleft-lip-and-palate-patients-surgical-technique-and-outcome-evaluation
#6
Gabor Vass, Gabor Mohos, Zsofia Bere, Laszlo Ivan, Janos Varga, Jozsef Piffko, Laszlo Rovo
BACKGROUND: Nasal deformity associated with cleft lip and palate is a highly challenging reconstructive problem in rhinoplasty. In the literature, several operative solutions and evaluation methods have been described, however these do not offer a standard procedure for the surgeon. Our aim was to standardize our surgical technique-as much as the uniqueness of each case allowed it-based on the most frequent deformities we had faced; and to evaluate our results via a postoperative patient satisfaction questionnaire...
December 1, 2016: Head & Face Medicine
https://www.readbyqxmd.com/read/27896037/functional-evaluation-of-patients-undergoing-multiple-joint-replacements-a-retrospective-study-of-50-patients-with-a-minimum-of-six-months-of-follow-up
#7
Shubhranshu S Mohanty, Nandan Mishra, Prateek Patil, Ajinkya Desale
INTRODUCTION:  Polyarthritis is a challenging condition that an orthopedic surgeon faces in day-to-day practice. Some of the conditions where multiple joints are affected are rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis. Multiple joint afflictions can cause severe impairment in the quality of life, which leads to a significant socioeconomic burden on the family and society. Joint replacement is considered as a treatment when severe joint pain or dysfunction is not alleviated by conservative management...
October 15, 2016: Curēus
https://www.readbyqxmd.com/read/27894585/pre-expanded-intercostal-perforator-super-thin-skin-flap
#8
REVIEW
Yunjun Liao, Yong Luo, Feng Lu, Hiko Hyakusoku, Jianhua Gao, Ping Jiang
This article introduces pre-expanded super-thin intercostal perforator flaps, particularly the flap that has a perforator from the first to second intercostal spaces. The key techniques, advantages and disadvantages, and complications and management of this flap are described. At present, the thinnest possible flap is achieved by thinning the pre-expanded flap that has a perforator from the first to second intercostal spaces. It is used to reconstruct large defects on the face and neck, thus restoring function and cosmetic appearance...
January 2017: Clinics in Plastic Surgery
https://www.readbyqxmd.com/read/27883365/educational-interventions-for-the-management-of-cancer-related-fatigue-in-adults
#9
REVIEW
Sally Bennett, Amanda Pigott, Elaine M Beller, Terry Haines, Pamela Meredith, Christie Delaney
BACKGROUND: Cancer-related fatigue is reported as the most common and distressing symptom experienced by patients with cancer. It can exacerbate the experience of other symptoms, negatively affect mood, interfere with the ability to carry out everyday activities, and negatively impact on quality of life. Educational interventions may help people to manage this fatigue or to cope with this symptom, and reduce its overall burden. Despite the importance of education for managing cancer-related fatigue there are currently no systematic reviews examining this approach...
November 24, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27877106/the-language-tone-and-prosody-of-emotions-neural-substrates-and-dynamics-of-spoken-word-emotion-perception
#10
REVIEW
Einat Liebenthal, David A Silbersweig, Emily Stern
Rapid assessment of emotions is important for detecting and prioritizing salient input. Emotions are conveyed in spoken words via verbal and non-verbal channels that are mutually informative and unveil in parallel over time, but the neural dynamics and interactions of these processes are not well understood. In this paper, we review the literature on emotion perception in faces, written words, and voices, as a basis for understanding the functional organization of emotion perception in spoken words. The characteristics of visual and auditory routes to the amygdala-a subcortical center for emotion perception-are compared across these stimulus classes in terms of neural dynamics, hemispheric lateralization, and functionality...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/27870614/active-inference-a-process-theory
#11
Karl Friston, Thomas FitzGerald, Francesco Rigoli, Philipp Schwartenbeck, Giovanni Pezzulo
This article describes a process theory based on active inference and belief propagation. Starting from the premise that all neuronal processing (and action selection) can be explained by maximizing Bayesian model evidence-or minimizing variational free energy-we ask whether neuronal responses can be described as a gradient descent on variational free energy. Using a standard (Markov decision process) generative model, we derive the neuronal dynamics implicit in this description and reproduce a remarkable range of well-characterized neuronal phenomena...
November 21, 2016: Neural Computation
https://www.readbyqxmd.com/read/27852003/the-neuropsychology-of-first-impressions-evidence-from-huntington-s-disease
#12
Reiner Sprengelmeyer, Andrew W Young, Eva-Maria Baldas, Iris Ratheiser, Clare A M Sutherland, Hans-Peter Müller, Georg Grön, Sigurd D Süssmuth, G Bernhard Landwehrmeyer, Michael Orth
Impairments of emotion recognition have been widely documented in Huntington's disease (HD), but little is known concerning how these relate to other aspects of social cognition, including first impressions of traits such as trustworthiness and dominance. Here, we introduce a novel and sensitive method to investigate the ability to evaluate trustworthiness and dominance from facial appearance, with control tasks measuring ability to perceive differences between comparable stimuli. We used this new method together with standard tests of face perception to investigate social cognition in HD...
October 21, 2016: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/27844312/frequency-of-penile-vaginal-intercourse-is-associated-with-verbal-recognition-performance-in-adult-women
#13
Larah Maunder, Dorothée Schoemaker, Jens C Pruessner
Previous studies have identified a number of factors that contribute to improved cognitive function, and to memory function specifically, in cognitively normal individuals. One such factor, frequency of penile-vaginal intercourse (PVI), has been reported in a number of animal studies to be advantageous to memory for previously presented objects by increasing neurogenesis in the dentate gyrus of the hippocampus. However, studies investigating the potential benefits of frequent PVI on memory function in young women are to the best of our knowledge absent from the literature...
November 14, 2016: Archives of Sexual Behavior
https://www.readbyqxmd.com/read/27815988/physical-attraction-to-reliable-low-variability-nervous-systems-reaction-time-variability-predicts-attractiveness
#14
Emily E Butler, Christopher W N Saville, Robert Ward, Richard Ramsey
The human face cues a range of important fitness information, which guides mate selection towards desirable others. Given humans' high investment in the central nervous system (CNS), cues to CNS function should be especially important in social selection. We tested if facial attractiveness preferences are sensitive to the reliability of human nervous system function. Several decades of research suggest an operational measure for CNS reliability is reaction time variability, which is measured by standard deviation of reaction times across trials...
January 2017: Cognition
https://www.readbyqxmd.com/read/27815210/function-of-cyp11a1-in-the-mitochondria
#15
Yu Chien, Karen Rosal, Bon-Chu Chung
Steroids are synthesized from the adrenal glands and gonads by enzymes of the cytochromes P450 and hydroxysteroid dehydrogenase in nature. These enzymes are located in the membrane of endoplasmic reticulum and mitochondria to catalyze redox reactions using electrons transported from the membrane. In the mitochondria, steroidogenic enzymes are inserted into the inner membrane with the bulk of the protein facing the matrix. They are not only important for steroid biosynthesis, their presence also affects mitochondrial morphology...
November 1, 2016: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/27810392/age-induced-differences-in-brain-neural-activation-elicited-by-visual-emotional-stimuli-a-high-density-eeg-study
#16
Anthoula C Tsolaki, Vasiliki E Kosmidou, Ioannis Yiannis Kompatsiaris, Chrysa Papadaniil, Leontios Hadjileontiadis, Magda Tsolaki
Identifying the brain sources of neural activation during processing of emotional information remains a very challenging task. In this work, we investigated the response to different emotional stimuli and the effect of age on the neuronal activation. Two negative emotion conditions, i.e., 'anger' and 'fear' faces were presented to 22 adult female participants (11 young and 11 elderly) while acquiring high-density electroencephalogram (EEG) data of 256 channels. Brain source localization was utilized to study the modulations in the early N170 event-related-potential component...
November 1, 2016: Neuroscience
https://www.readbyqxmd.com/read/27805283/increased-valvulo-arterial-impedance-differently-impacts-left-ventricular-longitudinal-circumferential-and-radial-function-in-patients-with-aortic-stenosis-a-speckle-tracking-echocardiography-study
#17
Elena Galli, Alain Leguerrier, Erwan Flecher, Christophe Leclercq, Erwan Donal
BACKGROUND: In aortic stenosis (AS), the left ventricle (LV) should face an increased afterload that is due to both the stenotic aortic valve and the peripheral vascular resistance (PVR). Valvulo-arterial impedance (ZVa ) is a recently introduced parameter, which permits the evaluation of global LV afterload in AS. Aim of this study was to assess the influence of increasing ZVa on the longitudinal, circumferential, and radial components of LV mechanics. METHODS: A total of 126 patients (mean age: 80...
November 2, 2016: Echocardiography
https://www.readbyqxmd.com/read/27794617/structural-evolution-of-core-shell-gold-nanoclusters-aun-n-42-50
#18
Seema Pande, Wei Huang, Nan Shao, Lei-Ming Wang, Navneet Khetrapal, Wai-Ning Mei, Tian Jian, Lai-Sheng Wang, Xiao Cheng Zeng
Gold nanoclusters have attracted great attention in the past decade due to their remarkable size-dependent electronic, optical, and catalytic properties. However, the structures of large gold clusters are still not well-known because of the challenges in global structural searches. Here we report a joint photoelectron spectroscopy (PES) and theoretical study of the structural evolution of negatively charged core-shell gold nanoclusters (Aun(-)) for n = 42-50. Photoelectron spectra of size-selected Aun(-) clusters are well resolved with distinct spectral features, suggesting a dominating structural type...
November 2, 2016: ACS Nano
https://www.readbyqxmd.com/read/27777904/genetics-of-prader-willi-syndrome-and-prader-will-like-syndrome
#19
REVIEW
Chong Kun Cheon
The Prader-Willi syndrome (PWS) is a human imprinting disorder resulting from genomic alterations that inactivate imprinted, paternally expressed genes in human chromosome region 15q11-q13. This genetic condition appears to be a contiguous gene syndrome caused by the loss of at least 2 of a number of genes expressed exclusively from the paternal allele, including SNRPN, MKRN3, MAGEL2, NDN and several snoRNAs, but it is not yet well known which specific genes in this region are associated with this syndrome...
September 2016: Annals of Pediatric Endocrinology & Metabolism
https://www.readbyqxmd.com/read/27773763/development-of-a-measure-of-hypodontia-patients-expectations-of-the-process-and-outcome-of-combined-orthodontic-and-restorative-treatment
#20
Afnan Ben Gassem, Richard Foxton, Dirk Bister, Tim Newton
OBJECTIVES: To devise and assess the psychometric properties of a measure that investigates hypodontia patients' expectations of the process and outcome of combined orthodontic/restorative treatment. SETTING: Specialised secondary care facility for individuals with hypodontia. MATERIALS AND METHODS: Mixed research design with three phases: (a) Thematic analysis of data from individual interviews with 25 hypodontia patients/16 parents to generate the questionnaire items...
October 20, 2016: Journal of Dentistry
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