keyword
https://read.qxmd.com/read/37972885/mitochondrial-malfunction-mediates-impaired-cholinergic-ca-2-signalling-and-submandibular-salivary-gland-dysfunction-in-diabetes
#21
JOURNAL ARTICLE
Olga Kopach, Tetyana Pivneva, Nataliya Fedirko, Nana Voitenko
Xerostomia (dry-mouth syndrome) is a painful and debilitating condition that frequently occurs in individuals with diabetes and is associated with impaired saliva production and salivary gland hypofunction. Saliva fluid production relies on Ca2+ -coupled secretion driven by neurotransmitter stimulation of submandibular acinar cells. Although impairments in intracellular Ca2+ signalling have been reported in various xerostomia models, the specific Ca2+ -dependent mechanisms underlying saliva fluid hypofunction in diabetes remain unclear...
February 1, 2024: Neuropharmacology
https://read.qxmd.com/read/37958888/compromised-muscle-properties-in-a-severe-hypophosphatasia-murine-model
#22
JOURNAL ARTICLE
Emily G Pendleton, Anna S Nichenko, Jennifer Mcfaline-Figueroa, Christiana J Raymond-Pope, Albino G Schifino, Taylor M Pigg, Ruth P Barrow, Sarah M Greising, Jarrod A Call, Luke J Mortensen
Hypophosphatasia (HPP) is a rare metabolic bone disorder characterized by low levels of tissue non-specific alkaline phosphatase (TNAP) that causes under-mineralization of the bone, leading to bone deformity and fractures. In addition, patients often present with chronic muscle pain, reduced muscle strength, and an altered gait. In this work, we explored dynamic muscle function in a homozygous TNAP knockout mouse model of severe juvenile onset HPP. We found a reduction in skeletal muscle size and impairment in a range of isolated muscle contractile properties...
November 2, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37953455/enhanced-mitochondrial-targeting-and-inhibition-of-pyroptosis-with-multifunctional-metallopolyphenol-nanoparticles-in-intervertebral-disc-degeneration
#23
JOURNAL ARTICLE
Hao Zhou, Qiuping Qian, Qizhu Chen, Tao Chen, Chenyu Wu, Linjie Chen, Zhiguang Zhang, Ouqiang Wu, Yuxin Jin, Xinzhou Wang, Zhenyu Guo, Jing Sun, Jun Zhang, Shuying Shen, Xiangyang Wang, Morgan Jones, Moonis Ali Khan, Pooyan Makvandi, Yunlong Zhou, Aimin Wu
Intervertebral disc degeneration (IVDD) is a significant contributor to low back pain, characterized by excessive reactive oxygen species generation and inflammation-induced pyroptosis. Unfortunately, there are currently no specific molecules or materials available to effectively delay IVDD. This study develops a multifunctional full name of PG@Cu nanoparticle network (PG@Cu). A designed pentapeptide, bonded on PG@Cu nanoparticles via a Schiff base bond, imparts multifunctionality to the metal polyphenol particles (PG@Cu-FP)...
November 12, 2023: Small
https://read.qxmd.com/read/37944527/inflammation-induced-mitochondrial-and-metabolic-disturbances-in-sensory-neurons-control-the-switch-from-acute-to-chronic-pain
#24
JOURNAL ARTICLE
Hanneke L D M Willemen, Patrícia Silva Santos Ribeiro, Melissa Broeks, Nils Meijer, Sabine Versteeg, Annefien Tiggeler, Teun P de Boer, Jędrzej M Małecki, Pål Ø Falnes, Judith Jans, Niels Eijkelkamp
Pain often persists in patients with an inflammatory disease, even when inflammation has subsided. The molecular mechanisms leading to this failure in pain resolution and the transition to chronic pain are poorly understood. Mitochondrial dysfunction in sensory neurons links to chronic pain, but its role in resolution of inflammatory pain is unclear. Transient inflammation causes neuronal plasticity, called hyperalgesic priming, which impairs resolution of pain induced by a subsequent inflammatory stimulus...
October 31, 2023: Cell reports medicine
https://read.qxmd.com/read/37925665/mitochondrial-dysfunction-a-new-molecular-mechanism-of-intervertebral-disc-degeneration
#25
REVIEW
Chao Song, Yulin Xu, Qinghua Peng, Rui Chen, Daqian Zhou, Kang Cheng, Weiye Cai, Tao Liu, Chenyi Huang, Zhijiang Fu, Cong Wei, Zongchao Liu
OBJECTIVE: Intervertebral disc degeneration (IVDD) is a chronic degenerative orthopedic illness that causes lower back pain as a typical clinical symptom, severely reducing patients' quality of life and work efficiency, and imposing a significant economic burden on society. IVDD is defined by rapid extracellular matrix breakdown, nucleus pulposus cell loss, and an inflammatory response. It is intimately related to the malfunction or loss of myeloid cells among them. Many mechanisms have been implicated in the development of IVDD, including inflammatory factors, oxidative stress, apoptosis, cellular autophagy, and mitochondrial dysfunction...
November 5, 2023: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://read.qxmd.com/read/37921887/-migraine-and-mitochondrial-diseases-energy-deficit-in-the-brain
#26
JOURNAL ARTICLE
Lucia Hämmerl, Torsten Kraya
Mitochondrial diseases are complex metabolic disorders caused by genetic mutations and lead to impaired energy production in the mitochondria of cells. The clinical spectrum ranges from severe multiorgan involvement in early childhood to mild monosymptomatic courses in adulthood. The brain, heart, and skeletal muscles are particularly affected due to their high energy demands. Headaches in general and migraine in particular, occur disproportionately more frequently in patients with mitochondrial diseases. In recent years similarities in the pathomechanism of mitochondrial diseases and migraine have been investigated in numerous biochemical, genetic, and therapeutic studies...
November 3, 2023: Der Schmerz
https://read.qxmd.com/read/37921169/targeting-the-main-sources-of-reactive-oxygen-species-production-possible-therapeutic-implications-in-chronic-pain
#27
JOURNAL ARTICLE
Peng-Fei Cheng, Yuan-He, Meng-Meng Ge, Da-Wei Ye, Jian-Ping Chen, Jin-Xi Wang
Humans have long been combating chronic pain. In clinical practice, opioids are first- choice analgesics, but long-term use of these drugs can lead to serious adverse reactions. Finding new, safe and effective pain relievers that are useful treatments for chronic pain is an urgent medical need. Based on accumulating evidence from numerous studies, excess reactive oxygen species (ROS) contribute to the development and maintenance of chronic pain. Some antioxidants are potentially beneficial analgesics in the clinic, but ROS-dependent pathways are completely inhibited only by scavenging ROS directly targeting cellular or subcellular sites...
October 25, 2023: Current Neuropharmacology
https://read.qxmd.com/read/37907151/mitochondrial-trafficking-as-a-protective-mechanism-against-chemotherapy-drug-induced-peripheral-neuropathy-identifying-the-key-site-of-action
#28
JOURNAL ARTICLE
Bayne Albin, Khayzaran Qubbaj, Arjun Prasad Tiwari, Prashant Adhikari, In Hong Yang
AIMS: Chemotherapy induced peripheral neuropathy (CIPN) is a common side effect seen in patients who have undergone most chemotherapy treatments to which there are currently no treatment methods. CIPN has been shown to cause axonal degeneration leading to Peripheral Neuropathy (PN), which can lead to major dosage reduction and may prevent further chemotherapy treatment due to oftentimes debilitating pain. Previously, we have determined the site-specific action of Paclitaxel (PTX), a microtubule targeting agent, as well as the neuroprotective effect of Fluocinolone Acetonide (FA) against Paclitaxel Induced Peripheral Neuropathy (PIPN)...
October 29, 2023: Life Sciences
https://read.qxmd.com/read/37876250/the-nlrx1-slc39a7-complex-orchestrates-mitochondrial-dynamics-and-mitophagy-to-rejuvenate-intervertebral-disc-by-modulating-mitochondrial-zn-2-trafficking
#29
JOURNAL ARTICLE
Yu Song, Huaizhen Liang, Gaocai Li, Liang Ma, Dingchao Zhu, Weifeng Zhang, Bide Tong, Shuai Li, Yong Gao, Xinghuo Wu, Yukun Zhang, Xiaobo Feng, Kun Wang, Cao Yang
Intervertebral disc degeneration (IDD) is the most critical pathological factor in the development of low back pain. The maintenance of nucleus pulposus (NP) cell and intervertebral disc integrity benefits largely from well-controlled mitochondrial quality, surveilled by mitochondrial dynamics (fission and fusion) and mitophagy, but the outcome is cellular context-dependent that remain to be clarified. Our studies revealed that the loss of NLRX1 is correlated with NP cell senescence and IDD progression, which involve disordered mitochondrial quality...
October 24, 2023: Autophagy
https://read.qxmd.com/read/37845039/mitochondrial-transplantation-attenuates-traumatic-neuropathic-pain-neuroinflammation-and-apoptosis-in-rats-with-nerve-root-ligation
#30
JOURNAL ARTICLE
Chi-Chen Huang, Hsin-Yi Chiu, Po-Hsuan Lee, Shih-Yuan Fang, Ming-Wei Lin, Hui-Fang Chen, Jung-Shun Lee
Traumatic neuropathic pain (TNP) is caused by traumatic damage to the somatosensory system and induces the presentation of allodynia and hyperalgesia. Mitochondrial dysfunction, neuroinflammation, and apoptosis are hallmarks in the pathogenesis of TNP. Recently, mitochondria-based therapy has emerged as a potential therapeutic intervention for diseases related to mitochondrial dysfunction. However, the therapeutic effectiveness of mitochondrial transplantation (MT) on TNP has rarely been investigated. Here, we validated the efficacy of MT in treating TNP...
October 16, 2023: Molecular Pain
https://read.qxmd.com/read/37832908/melatonin-improves-mitochondrial-dysfunction-and-attenuates-neuropathic-pain-by-regulating-sirt1-in-dorsal-root-ganglions
#31
JOURNAL ARTICLE
Yanyan Zeng, Qian Fang, Jiali Chen, Yaping Wang, Xinli Liu, Xuefei Zhang, Yu Shi, Hongrui Zhan, Xiongxiong Zhong, Mengyu Yao, Huai Huang, Wen Wu
Neuropathic pain is a debilitating chronic pain condition and is refractory to the currently available treatments. Emerging evidence suggests that melatonin exerts analgesic effects in rodent models of neuropathic pain. Nevertheless, the exact underlying mechanisms of the analgesic effects of melatonin on neuropathic pain are largely unknown. Here, we observed that spinal nerve ligation (SNL) in rats L5 and L6 induced an obvious decrease in the 50% paw withdrawal threshold (PWT) and paw withdrawal latency (PWL), indicating the induction of mechanical allodynia and the hyperalgesia, and melatonin prevented the genesis and maintenance of mechanical allodynia and the hyperalgesia...
December 1, 2023: Neuroscience
https://read.qxmd.com/read/37831362/tramadol-induces-apoptosis-inflammation-and-oxidative-stress-in-rat-choroid-plexus
#32
JOURNAL ARTICLE
Maryam Mehranpour, Meysam Hassani Moghaddam, Mohammad-Amin Abdollahifar, Mitra Salehi, Abbas Aliaghaei
BACKGROUND: The choroid plexus (CP) is the principal source of cerebrospinal fluid (CSF). It can produce and release a wide range of materials, including growth and neurotrophic factors which have a crucial role in the maintenance and proper functioning of the brain. Tramadol is a synthetic analog of codeine, mainly prescribed to alleviate mild to moderate pains. Nevertheless, it causes several side effects, such as emotional instability and anxiety. METHODS: In this study, we focused on alterations in the expression of inflammatory and apoptotic genes in the CP under chronic tramadol exposure...
October 13, 2023: Metabolic Brain Disease
https://read.qxmd.com/read/37814752/elucidating-the-mechanisms-of-pulsed-radiofrequency-for-pain-treatment
#33
REVIEW
Jonathan De la Cruz, Daniel Benzecry Almeida, Mayara Silva Marques, Ricardo Ramina, Rodolfo Jorge Fortes Kubiak
Pulsed radiofrequency is a well-documented treatment option for multiple painful conditions where pulses of energy are delivered close to neural elements. Since its earliest adoption, this technique has gained increasing acceptance as a minimally invasive procedure, and new applications are evolving. Studies have shown microscopic and biochemical changes that reflect beneficial effects; however, the exact mechanism of action is not yet completely understood. To redress this paucity, 11,476 articles of scientific relevance published between 1980 and November 2022 were mined through a search of the PubMed database, arriving at 49 studies both in animals and humans...
September 2023: Curēus
https://read.qxmd.com/read/37783233/poly-adp-ribose-polymerase-1-and-parthanatos-in-neurological-diseases-from-pathogenesis-to-therapeutic-opportunities
#34
REVIEW
Xiaoxue Xu, Bowen Sun, Chuansheng Zhao
Poly (ADP-ribose) polymerase-1 (PARP-1) is the most extensively studied member of the PARP superfamily, with its primary function being the facilitation of DNA damage repair processes. Parthanatos is a type of regulated cell death cascade initiated by PARP-1 hyperactivation, which involves multiple subroutines, including the accumulation of ADP-ribose polymers (PAR), binding of PAR and apoptosis-inducing factor (AIF), release of AIF from the mitochondria, the translocation of the AIF/macrophage migration inhibitory factor (MIF) complex, and massive MIF-mediated DNA fragmentation...
September 30, 2023: Neurobiology of Disease
https://read.qxmd.com/read/37749630/myd88-dimerization-inhibitor-st2825-targets-the-aggressiveness-of-synovial-fibroblasts-in-rheumatoid-arthritis-patients
#35
JOURNAL ARTICLE
Sergio Ramirez-Perez, Rushi Vekariya, Surabhi Gautam, Itzel Viridiana Reyes-Perez, Hicham Drissi, Pallavi Bhattaram
BACKGROUND: Dimerization of the myeloid differentiation primary response 88 protein (MyD88) plays a pivotal role in the exacerbated response to innate immunity-dependent signaling in rheumatoid arthritis (RA). ST2825 is a highly specific inhibitor of MyD88 dimerization, previously shown to inhibit the pro-inflammatory gene expression in peripheral blood mononuclear cells from RA patients (RA PBMC). In this study, we elucidated the effect of disrupting MyD88 dimerization by ST2825 on the pathological properties of synovial fibroblasts from RA patients (RA SFs)...
September 25, 2023: Arthritis Research & Therapy
https://read.qxmd.com/read/37734472/cholinergic-signaling-of-muscarinic-receptors-directly-involves-in-the-neuroprotection-of-muscone-by-inducing-ca-2-antagonism-and-maintaining-mitochondrial-function
#36
JOURNAL ARTICLE
Gang Shen, Zongyuan Zhou, Yanlei Guo, Li Li, Jin Zeng, Jianbo Wang, Junning Zhao
ETHNOPHARMACOLOGICAL RELEVANCE: Musk, a traditional Chinese medicine, is broadly used in inducing resuscitation and refreshing the mind, activating blood and alleviating pain. It is commonly used for the treatment of ischemic stroke, and muscone is its core medicinal component. AIM OF THE STUDY: The aim of this study was to explore whether muscone ameliorates neuronal damage through cholinergic signaling of muscarinic receptors. MATERIALS AND METHODS: The effects of muscone were tested in a rat model of middle cerebral artery occlusion (MCAO) as well as injured neurons induced by oxygen-glucose deprivation (OGD) in PC12 cells...
September 19, 2023: Journal of Ethnopharmacology
https://read.qxmd.com/read/37723417/dexamethasone-inhibits-il-8-via-glycolysis-and-mitochondria-related-pathway-to-regulate-inflammatory-pain
#37
JOURNAL ARTICLE
Ren He, Xiaohan Li, Silun Zhang, Yuqiang Liu, Qingsheng Xue, Yan Luo, Buwei Yu, Xiongjuan Li, Zhiheng Liu
BACKGROUND: Dexamethasone (Dexa) has been recently found to exert an analgesic effect, whose action is closely related to IL-8. However, whether dexamethasone induces antinociception via glycolysis and mitochondria-related pathways is still unclear. METHODS: Right hind paw inflammatory pain in mice was induced by intraplantar injection of Freund's Complete Adjuvant (FCA). Von Frey test was then used to measure the paw withdrawal threshold. The detection of glycolysis and mitochondrial pathway-related proteins and IL-8 were determined by Western blot and ELISA...
September 18, 2023: BMC Anesthesiology
https://read.qxmd.com/read/37681703/the-role-of-mitochondrial-dynamics-in-the-pathophysiology-of-endometriosis
#38
REVIEW
Hiroshi Kobayashi, Sho Matsubara, Chiharu Yoshimoto, Hiroshi Shigetomi, Shogo Imanaka
AIM: Endometriosis is a chronic disease of reproductive age, associated with pelvic pain and infertility. Endometriotic cells adapt to changing environments such as oxidative stress and hypoxia in order to survive. However, the underlying mechanisms remain to be fully elucidated. In this review, we summarize our current understanding of the pathogenesis of endometriosis, focusing primarily on the molecular basis of energy metabolism, redox homeostasis, and mitochondrial function, and discuss perspectives on future research directions...
September 8, 2023: Journal of Obstetrics and Gynaecology Research
https://read.qxmd.com/read/37673358/nicotinic-acetylcholine-receptors-in-cancer-limitations-and-prospects
#39
REVIEW
T Bele, T Turk, I Križaj
Nicotinic acetylcholine receptors (nAChRs) have long been considered to solely mediate neurotransmission. However, their widespread distribution in the human body suggests a more diverse physiological role. Additionally, the expression of nAChRs is increased in certain cancers, such as lung cancer, and has been associated with cell proliferation, epithelial-to-mesenchymal cell transition, angiogenesis and apoptosis prevention. Several compounds that interact with these receptors have been identified as potential therapeutic agents...
September 4, 2023: Biochimica et Biophysica Acta. Molecular Basis of Disease
https://read.qxmd.com/read/37673019/targeting-mitochondrial-circadian-rhythms-the-potential-intervention-strategies-of-traditional-chinese-medicine-for-myocardial-ischaemia%C3%A2-reperfusion-injury
#40
REVIEW
Zhihui Song, Zhihua Yang, Lin Tian, Yangxi Liu, Zehui Guo, Qiuju Zhang, Yuhang Zhang, Tao Wen, Haowei Xu, Zhenzhen Li, Yi Wang
Coronary artery disease has one of the highest mortality rates in the country, and methods such as thrombolysis and percutaneous coronary intervention (PCI) can effectively improve symptoms and reduce mortality, but most patients still experience symptoms such as chest pain after PCI, which seriously affects their quality of life and increases the incidence of adverse cardiovascular events (myocardial ischaemiareperfusion injury, MIRI). MIRI has been shown to be closely associated with circadian rhythm disorders and mitochondrial dysfunction...
September 4, 2023: Biomedicine & Pharmacotherapy
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