Chao Song, Yulin Xu, Qinghua Peng, Rui Chen, Daqian Zhou, Kang Cheng, Weiye Cai, Tao Liu, Chenyi Huang, Zhijiang Fu, Cong Wei, Zongchao Liu
OBJECTIVE: Intervertebral disc degeneration (IVDD) is a chronic degenerative orthopedic illness that causes lower back pain as a typical clinical symptom, severely reducing patients' quality of life and work efficiency, and imposing a significant economic burden on society. IVDD is defined by rapid extracellular matrix breakdown, nucleus pulposus cell loss, and an inflammatory response. It is intimately related to the malfunction or loss of myeloid cells among them. Many mechanisms have been implicated in the development of IVDD, including inflammatory factors, oxidative stress, apoptosis, cellular autophagy, and mitochondrial dysfunction...
November 5, 2023: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]