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Mitochondria AND pain

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https://www.readbyqxmd.com/read/28074859/identifying-a-gene-expression-signature-of-cluster-headache-in-blood
#1
Else Eising, Nadine Pelzer, Lisanne S Vijfhuizen, Boukje de Vries, Michel D Ferrari, Peter A C 't Hoen, Gisela M Terwindt, Arn M J M van den Maagdenberg
Cluster headache is a relatively rare headache disorder, typically characterized by multiple daily, short-lasting attacks of excruciating, unilateral (peri-)orbital or temporal pain associated with autonomic symptoms and restlessness. To better understand the pathophysiology of cluster headache, we used RNA sequencing to identify differentially expressed genes and pathways in whole blood of patients with episodic (n = 19) or chronic (n = 20) cluster headache in comparison with headache-free controls (n = 20)...
January 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28055010/continued-26s-proteasome-dysfunction-in-mouse-brain-cortical-neurons-impairs-autophagy-and-the-keap1-nrf2-oxidative-defence-pathway
#2
Aslihan Ugun-Klusek, Michael H Tatham, Jamal Elkharaz, Dumitru Constantin-Teodosiu, Karen Lawler, Hala Mohamed, Simon M L Paine, Glen Anderson, R John Mayer, James Lowe, E Ellen Billett, Lynn Bedford
The ubiquitin-proteasome system (UPS) and macroautophagy (autophagy) are central to normal proteostasis and interdependent in that autophagy is known to compensate for the UPS to alleviate ensuing proteotoxic stress that impairs cell function. UPS and autophagy dysfunctions are believed to have a major role in the pathomechanisms of neurodegenerative disease. Here we show that continued 26S proteasome dysfunction in mouse brain cortical neurons causes paranuclear accumulation of fragmented dysfunctional mitochondria, associated with earlier recruitment of Parkin and lysine 48-linked ubiquitination of mitochondrial outer membrane (MOM) proteins, including Mitofusin-2...
January 5, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/27922495/toxic-and-endocrine-myopathies
#3
Hans D Katzberg, Charles D Kassardjian
PURPOSE OF REVIEW: This article discusses the clinical features, pathophysiology, and management of toxic and endocrine myopathies. RECENT FINDINGS: Early detection and expeditious correction of metabolic disturbances in endocrinopathies such as Cushing syndrome, thyroid and parathyroid diseases, and acromegaly can minimize and prevent neurologic complications including myopathy. Recently proposed mechanisms of injury in patients with critical illness myopathy include inhibition of protein synthesis, mitochondrial dysfunction, disruption of the ubiquitin-proteasome system, oxidative stress, and disruption of intramuscular calcium homeostasis, which can cause a myosin-loss myopathy...
December 2016: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/27870427/understanding-the-broad-influence-of-sex-hormones-and-sex-differences-in-the-brain
#4
REVIEW
Bruce S McEwen, Teresa A Milner
Sex hormones act throughout the entire brain of both males and females via both genomic and nongenomic receptors. Sex hormones can act through many cellular and molecular processes that alter structure and function of neural systems and influence behavior as well as providing neuroprotection. Within neurons, sex hormone receptors are found in nuclei and are also located near membranes, where they are associated with presynaptic terminals, mitochondria, spine apparatus, and postsynaptic densities. Sex hormone receptors also are found in glial cells...
January 2, 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/27799181/mitovite-a-mitochondria-targeted-antioxidant-limits-paclitaxel-induced-oxidative-stress-and-mitochondrial-damage-in-vitro-and-paclitaxel-induced-mechanical-hypersensitivity-in-a-rat-pain-model
#5
B McCormick, D A Lowes, L Colvin, C Torsney, H F Galley
BACKGROUND: Neuropathic pain is a common side-effect of chemotherapy. Although precise mechanisms are unclear, oxidative stress and mitochondrial damage are involved. We investigated whether the mitochondria targeted antioxidant, MitoVitE, provided better protection against paclitaxel-induced mitochondrial damage in rat dorsal root ganglion (DRG) cells, than a non-targeted form of vitamin E, Trolox. We also determined whether MitoVitE, compared with duloxetine, could limit paclitaxel-induced mechanical hypersensitivity in rats...
November 2016: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/27779235/one-compound-of-saponins-from-disocorea-zingiberensis-protected-against-experimental-acute-pancreatitis-by-preventing-mitochondria-mediated-necrosis
#6
Rui Zhang, Li Wen, Yan Shen, Na Shi, Zhihua Xing, Qing Xia, Hai Niu, Wen Huang
Acute pancreatitis (AP) is a painful inflammatory disorder of the exocrine pancreas, ranking as the most common gastrointestinal reasons for hospitalization with no specific therapy currently. Diosgenyl saponins extracted from natural products and diosgenin or its derivatives have been shown to exert anti-inflammatory effects in various diseases. However, the therapeutic effects of diosgenyl saponins from Dioscorea zingiberensis C. H. Wright in AP have not yet been determined. Five compounds were extracted and screened for taurocholate-induced necrosis in mouse pancreatic acinar cells...
October 25, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27760222/mitochondrial-respiration-after-one-session-of-calf-raise-exercise-in-patients-with-peripheral-vascular-disease-and-healthy-older-adults
#7
Michel van Schaardenburgh, Martin Wohlwend, Øivind Rognmo, Erney J R Mattsson
PURPOSE: Mitochondria are essential for energy production in the muscle cell and for this they are dependent upon a sufficient supply of oxygen by the circulation. Exercise training has shown to be a potent stimulus for physiological adaptations and mitochondria play a central role. Whether changes in mitochondrial respiration are seen after exercise in patients with a reduced circulation is unknown. The aim of the study was to evaluate the time course and whether one session of calf raise exercise stimulates mitochondrial respiration in the calf muscle of patients with peripheral vascular disease...
2016: PloS One
https://www.readbyqxmd.com/read/27738674/in-vitro-characterization-of-a-novel-isu-homologue-from-drosophila-melanogaster-for-de-novo-fes-cluster-formation
#8
Stephen P Dzul, Agostinho G Rocha, Swati Rawat, Ashoka Kandegedara, April Kusowski, Jayashree Pain, Anjaneyulu Murari, Debkumar Pain, Andrew Dancis, Timothy L Stemmler
FeS-clusters are utilized by numerous proteins within several biological pathways that are essential for life. In eukaryotes, the primary FeS-cluster production pathway is the mitochondrial iron-sulfur cluster (ISC) pathway. In Saccharomyces cerevisiae, de novo FeS-cluster formation is accomplished through coordinated assembly with the substrates iron and sulfur by the scaffold assembly protein "Isu1". Sulfur for cluster assembly is provided by cysteine desulfurase "Nfs1", a protein that works in union with its accessory protein "Isd11"...
October 14, 2016: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/27671317/transient-receptor-potential-vanilloid-1-regulates-mitochondrial-membrane-potential-and-myocardial-reperfusion-injury
#9
Carl M Hurt, Yao Lu, Creed M Stary, Honit Piplani, Bryce A Small, Travis J Urban, Nir Qvit, Garrett J Gross, Daria Mochly-Rosen, Eric R Gross
BACKGROUND: The transient receptor potential vanilloid 1 (TRPV1) mediates cellular responses to pain, heat, or noxious stimuli by calcium influx; however, the cellular localization and function of TRPV1 in the cardiomyocyte is largely unknown. We studied whether myocardial injury is regulated by TRPV1 and whether we could mitigate reperfusion injury by limiting the calcineurin interaction with TRPV1. METHODS AND RESULTS: In primary cardiomyocytes, confocal and electron microscopy demonstrates that TRPV1 is localized to the mitochondria...
26, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27631263/submandibular-oncocytic-carcinoma-a-case-report-and-literature-review
#10
Hai Xiao, Tingyu Wen, Xinzheng Liu
BACKGROUND: Oncocytic carcinoma (OC) arising in the submandibular gland is an unusual malignant neoplasm, with <20 cases previously reported. The cancer is characterized by numerous morphologically abnormal mitochondria present in the cytoplasm and marked cellular pleomorphism. At its most severe, the tumor may invade into the surrounding tissues, including intravascular, lymphatic, or perineural invasion, and lead to regional nodal or distant metastasis. METHODS: The current study describes a novel OC case in a 46-year-old male, the youngest case of the review...
September 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27535875/ultrastructural-aspects-of-mouse-nerve-muscle-preparation-exposed-to-bothrops-jararacussu-and-bothrops-bilineatus-venoms-and-their-toxins-bthtx-i-and-bbil-tx-unknown-myotoxic-effects
#11
Rodolfo Melaré, Rafael Stuani Floriano, Marta Gracia, Léa Rodrigues-Simioni, Maria Alice da Cruz-Höfling, Thalita Rocha
Bites by Bothrops snakes normally induce local pain, haemorrhage, oedema and myonecrosis. Mammalian isolated nerve-muscle preparations exposed to Bothrops venoms and their phospholipase A2 toxins (PLA2 ) can exhibit a neurotoxic pattern as increase in frequency of miniature end-plate potentials (MEPPs) as well as in amplitude of end-plate potentials (EPPs); neuromuscular facilitation followed by complete and irreversible blockade without morphological evidence for muscle damage. In this work, we analysed the ultrastructural damage induced by Bothrops jararacussu and Bothrops bilineatus venoms and their PLA2 toxins (BthTX-I and Bbil-TX) in mouse isolated nerve-phrenic diaphragm preparations (PND)...
August 18, 2016: Microscopy Research and Technique
https://www.readbyqxmd.com/read/27497633/neuroprotective-effects-of-melatonin-as-evidenced-by-abrogation-of-oxaliplatin-induced-behavioral-alterations-mitochondrial-dysfunction-and-neurotoxicity-in-rat-brain
#12
Mohammad Waseem, Heena Tabassum, Suhel Parvez
Neurotoxicity is a burdensome consequence of platinum-based chemotherapy that neutralizes the administration of effective dosage and often prompts treatment withdrawal. Oxaliplatin (Oxa), a third-era platinum analogue that is active against both early-organize and progressed colorectal growth, produces critical neurotoxicity. It has been reported that the Melatonin (Mel) is a pineal hormone its metabolites display important antioxidant properties in nervous system. There is dearth of literature involving the role of mitochondria and cytosolic compartments mediated Oxa-induced neurotoxicity and its underlying mechanisms are still debatable...
September 2016: Mitochondrion
https://www.readbyqxmd.com/read/27325560/mycolactone-mediated-neurite-degeneration-and-functional-effects-in-cultured-human-and-rat-drg-neurons-mechanisms-underlying-hypoalgesia-in-buruli-ulcer
#13
U Anand, M Sinisi, M Fox, A MacQuillan, T Quick, Y Korchev, C Bountra, T McCarthy, P Anand
BACKGROUND: Mycolactone is a polyketide toxin secreted by the mycobacterium Mycobacterium ulcerans, responsible for the extensive hypoalgesic skin lesions characteristic of patients with Buruli ulcer. A recent pre-clinical study proposed that mycolactone may produce analgesia via activation of the angiotensin II type 2 receptor (AT2R). In contrast, AT2R antagonist EMA401 has shown analgesic efficacy in animal models and clinical trials for neuropathic pain. We therefore investigated the morphological and functional effects of mycolactone in cultured human and rat dorsal root ganglia (DRG) neurons and the role of AT2R using EMA401...
2016: Molecular Pain
https://www.readbyqxmd.com/read/27301366/-dmt-1-dalda-analogues-modified-with-tyrosine-analogues-at-position-1
#14
Yunxin Cai, Dandan Lu, Zhen Chen, Yi Ding, Nga N Chung, Tingyou Li, Peter W Schiller
Analogues of [Dmt(1)]DALDA (H-Dmt-d-Arg-Phe-Lys-NH2; Dmt=2',6'-dimethyltyrosine), a potent μ opioid agonist peptide with mitochondria-targeted antioxidant activity were prepared by replacing Dmt with various 2',6'-dialkylated Tyr analogues, including 2',4',6'-trimethyltyrosine (Tmt), 2'-ethyl-6'-methyltyrosine (Emt), 2'-isopropyl-6'-methyltyrosine (Imt) and 2',6'-diethyltyrosine (Det). All compounds were selective μ opioid agonists and the Tmt(1)-, Emt(1) and Det(1)-analogues showed subnanomolar μ opioid receptor binding affinities...
August 1, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/27274778/the-analgesic-effect-of-the-mitochondria-targeted-antioxidant-skq1-in-pancreatic-inflammation
#15
Maximilian Weniger, Leonard Reinelt, Jens Neumann, Lesca Holdt, Matthias Ilmer, Bernhard Renz, Werner Hartwig, Jens Werner, Alexandr V Bazhin, Jan G D'Haese
Background. Chronic pancreatitis is one of the main risk factors for pancreatic cancer. In acute and chronic pancreatitis, oxidative stress is thought to play a key role. In this respect, the recently described mitochondria-targeted antioxidant SkQ1 effectively scavenges reactive oxygen species at nanomolar concentrations. Therefore, we aimed to characterize the influence of SkQ1 on tissue injury and pain in acute and chronic pancreatitis. Methods. Both acute and chronic pancreatitis were induced in C57BL/6 mice by intraperitoneal cerulein injections and treatment with SkQ1 was carried out by peroral applications...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27131956/dexmedetomidine-reduces-neuropathic-pain-in-a-rat-model-of-skin-muscle-incision-and-retraction
#16
Xizhao Huang, Rongfang Deng, Weifeng Tu, Zurong Hu
BACKGROUND: Dexmedetomidine has been proposed as a novel anesthetic adjuvant. However, it remains unclear whether peripheral administration of dexmedetomidine is safe and effective to reduce acute postoperative pain. This study aimed to examine the effects of dexmedetomidine on neuropathic pain. METHODS: Adult male Sprague-Dawley rats were anaesthetized and randomly allocated into four groups (n = 8): Groups S, R, RD1, and RD5 were injected with saline, 0.5% ropivacaine, 0...
January 2017: Asian Journal of Surgery
https://www.readbyqxmd.com/read/27119009/the-natural-polyphenol-epigallocatechin-gallate-protects-intervertebral-disc-cells-from-oxidative-stress
#17
Olga Krupkova, Junichi Handa, Marian Hlavna, Juergen Klasen, Caroline Ospelt, Stephen John Ferguson, Karin Wuertz-Kozak
Oxidative stress-related phenotypic changes and a decline in the number of viable cells are crucial contributors to intervertebral disc degeneration. The polyphenol epigallocatechin 3-gallate (EGCG) can interfere with painful disc degeneration by reducing inflammation, catabolism, and pain. In this study, we hypothesized that EGCG furthermore protects against senescence and/or cell death, induced by oxidative stress. Sublethal and lethal oxidative stress were induced in primary human intervertebral disc cells with H2O2 (total n = 36)...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27100509/the-neurobiology-of-acetyl-l-carnitine
#18
Giovanna Traina
A large body of evidence points to the positive effects of dietary supplementation of acetyl-L-carnitine (ALC). Its use has shown health benefits in neuroinflammation, which is a common denominator in a host of neurodegenerative diseases. ALC is the principal acetyl ester of L-Carnitine (LC), and it plays an essential role in intermediary metabolism, acting as a donor of acetyl groups and facilitating the transfer of fatty acids from cytosol to mitochondria during beta-oxidation. Dietary supplementation of ALC exerts neuroprotective, neurotrophic, antidepressive and analgesic effects in painful neuropathies...
2016: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/27085813/sodium-channels-mitochondria-and-axonal-degeneration-in-peripheral-neuropathy
#19
REVIEW
Anna-Karin Persson, Janneke G J Hoeijmakers, Mark Estacion, Joel A Black, Stephen G Waxman
Peripheral neuropathy results from damage to peripheral nerves and is often accompanied by pain in affected limbs. Treatment represents an unmet medical need and a thorough understanding of the mechanisms underlying axonal injury is needed. Longer nerve fibers tend to degenerate first (length-dependence), and patients carrying pathogenic mutations throughout life usually become symptomatic in mid- or late-life (time-dependence). The activity of voltage-gated sodium channels can contribute to axonal injury and sodium channel gain-of-function mutations have been linked to peripheral neuropathy...
May 2016: Trends in Molecular Medicine
https://www.readbyqxmd.com/read/27082059/apoptotic-effects-of-extract-from-cnidium-monnieri-l-cusson-by-adenosine-monosphosphate-activated-protein-kinase-independent-pathway-in-hct116-colon-cancer-cells
#20
Eun Gyeong Lim, Guen Tae Kim, Se Hee Lee, Sang-Yong Kim, Young Min Kim
Colon cancer, a common malignancy, can occur due to poor eating habits and increasing age. Consequently, careful regulation of eating habits may serve as a possible method for preventing the occurrence or progression of colon cancer. Extracts of the fruit of Cnidium monnieri (L.) Cusson are well‑known as an effective herbal medicine for the treatment of pain in female genitalia and carbuncle. However, there have been no studies on the apoptotic effects of Cnidium monnieri (L.) Cusson (CME). Adenosine monophosphate‑activated protein kinase (AMPK), the major regulator of energy metabolism, is activated by metabolic stress, including hypoxia and glucose deprivation...
June 2016: Molecular Medicine Reports
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