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https://www.readbyqxmd.com/read/29774313/echoes-from-the-40-th-annual-san-antonio-breast-cancer-symposium-2017
#1
Bekir Kuru
The Annual San Antonio Symposium was held on 5-9, December, 2017 in San Antonio, Texas, USA (1). As expected, many new studies were presented for the first time at the sessions. The unofficial opening lecture in my point of view was given on locoregional recurrence by Monica Morrow from MSKCC, New York. As always, Morrow's lecture on "Challenges in the surgical management of locoregional recurrence" attracted great interest. The other prominent conferences were given on "Individualizing Management of the Axillary Nodes" by Tari A...
April 2018: European Journal of Breast Health
https://www.readbyqxmd.com/read/29773777/seeking-biomarkers-of-early-childhood-malnutrition-s-long-term-effects
#2
Pedro A Valdés-Sosa, Janina R Galler, Cyralene P Bryce, Arielle G Rabinowitz, María L Bringas-Vega, Nibaldo Hernández-Mesa, Alberto Taboada-Crispi
Protein-energy malnutrition affects one in nine people worldwide and is most prevalent among children aged less than five years in low-income countries. Early childhood malnutrition can have damaging neurodevelopmental effects, with significant increases in cognitive, neurological and mental health problems over the lifespan, outcomes which can also extend to the next generation. This article describes a research collaboration involving scientists from five centers in Barbados, China, Cuba and the USA. It builds on longer-term joint work between the Barbados Nutrition Study (which, over a 45-year span, has extensively documented nutritional, health, behavioral, social and economic outcomes of individuals who experienced protein-energy malnutrition in the first year of life and healthy controls from the same classrooms and neighborhoods) and the Cuban Neuroscience Center (which has developed low-cost brain imaging methods that can be readily used in low income settings to identify biomarkers for early detection and treatment of adverse consequences of childhood malnutrition)...
April 2018: MEDICC Review
https://www.readbyqxmd.com/read/29773775/case-study-in-international-cooperation-cuba-s-molecular-immunology-center-and-roswell-park-cancer-institute
#3
Rachel Evans, Mary Reid, Brahm Segal, Scott I Abrams, Kelvin Lee
In 1961, the USA severed diplomatic relations with Cuba, and in 1962 an embargo was imposed on trade and financial relations with that country. It was not until five decades later that the USA and Cuba would reestablish relations. This opened the way for the New York State Trade Mission to Cuba in April 2015, during which Cuba's Molecular Immunology Center and Buffalo, New York's Roswell Park Cancer Institute signed a formal agreement that would set in motion biotechnology research collaboration to address one of the most important causes of death in both countries...
April 2018: MEDICC Review
https://www.readbyqxmd.com/read/29772049/mild-bilateral-hemorrhagic-occlusive-retinal-vasculitis-following-intracameral-vancomycin-administration-in-cataract-surgery
#4
Sruthi Arepalli, Yasha S Modi, Ryan Deasy, Sunil K Srivastava
A patient underwent cataract surgery with prophylactic intracameral vancomycin (Vancocin; Pfizer, New York City, NY) in each eye, 2 weeks apart. Four weeks after, the patient presented with a mild bilateral hemorrhagic occlusive retinal vasculitis (HORV). A systemic work-up was negative for syphilis, toxoplasmosis, Bartonella, tuberculosis, and sarcoidosis. The patient was treated with oral steroids and one intravitreal steroid injection in the left eye. Ten months after presentation, the patient's vasculitis was quiescent...
May 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/29771742/multiple-chronic-conditions-and-disparities-in-30-day-hospital-readmissions-among-nonelderly-adults
#5
Jayasree Basu, Amresh Hanchate, Siran Koroukian
This study examines the patterns of 30-day hospital readmissions by race/ethnicity and multiple chronic conditions (MCC) burden among nonelderly adult patients. We used hospital discharge data of patients in the 18- to 64-year age group in 5 US states, California, Florida, Missouri, New York, and Tennessee, for 2009 from the Healthcare Cost and Utilization Project State Inpatient Database (HCUP-SID) of the Agency for Healthcare Research and Quality, linked to contextual and provider data from the Health Resources and Services Administration...
May 15, 2018: Journal of Ambulatory Care Management
https://www.readbyqxmd.com/read/29771478/the-reverse-remodeling-response-to-sacubitril-valsartan-therapy-in-heart-failure-with-reduced-ejection-fraction
#6
Pieter Martens, Hanne Beliën, Matthias Dupont, Pieter Vandervoort, Wilfried Mullens
BACKGROUND: Major classes of medical therapy for heart failure with reduced ejection fraction (HFrEF) induce reverse remodeling. The revere remodeling response to sacubitril/valsartan remains unstudied. METHODS: We performed a single-center, prospective assessor-blinded study to determine the reverse remodeling response of sacubitril/valsartan-therapy in HFrEF-patients with a class I-indication (New York heart Association [NYHA]-class II-IV, Left ventricular ejection fraction [LVEF]<35%, optimal dose with Renin-Angiotensin-System-Blocker [RAS-blocker])...
May 17, 2018: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/29771374/our-inner-city-children-inflicted-with-burns-a-retrospective-analysis-of-pediatric-burn-admissions-at-harlem-hospital-ny
#7
Anant Dinesh, Thais Polanco, Khurram Khan, Alexius Ramcharan, Ryan Engdahl
Pediatric burns in the urban environment present special problems. Inner-city communities may be unique with hardships due to various socioeconomic factors. There is lack of literature analyzing pediatric burns in the inner-city, and there has been no report to date reviewing Harlem New York City, one of the most challenged areas in the nation. The aim of this study is to understand the pre-hospital circumstances, socioeconomic factors and management of pediatric burns admitted to our hospital. A retrospective review was performed including all patients aged 0-18 years admitted to the burn care unit from January 2006-May 2017...
May 16, 2018: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/29770138/ny-eso-1-based-immunotherapy-of-cancer-current-perspectives
#8
REVIEW
Remy Thomas, Ghaneya Al-Khadairi, Jessica Roelands, Wouter Hendrickx, Said Dermime, Davide Bedognetti, Julie Decock
NY-ESO-1 or New York esophageal squamous cell carcinoma 1 is a well-known cancer-testis antigen (CTAs) with re-expression in numerous cancer types. Its ability to elicit spontaneous humoral and cellular immune responses, together with its restricted expression pattern, have rendered it a good candidate target for cancer immunotherapy. In this review, we provide background information on NY-ESO-1 expression and function in normal and cancerous tissues. Furthermore, NY-ESO-1-specific immune responses have been observed in various cancer types; however, their utility as biomarkers are not well determined...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29769304/first-person-chih-wen-chu
#9
(no author information available yet)
First Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping early-career researchers promote themselves alongside their papers. Chih-Wen Chu is the first author on 'The Ajuba family protein Wtip regulates actomyosin contractility during vertebrate neural tube closure', published in Journal of Cell Science. Chih-Wen is an associate scientist in the lab of Sergei Sokol at Icahn School of Medicine at Mount Sinai, New York, USA, investigating apical constriction and planar cell polarity, with a focus on protein dynamics at the cell junctions...
May 16, 2018: Journal of Cell Science
https://www.readbyqxmd.com/read/29768714/detection-of-an-avian-lineage-influenza-a-h7n2-virus-in-air-and-surface-samples-at-a-new-york-city-feline-quarantine-facility
#10
Francoise M Blachere, William G Lindsley, Angela M Weber, Donald H Beezhold, Robert E Thewlis, Kenneth R Mead, John D Noti
BACKGROUND: In December 2016, an outbreak of low pathogenicity avian influenza (LPAI) A(H7N2) occurred in cats at a New York City animal shelter and quickly spread to other shelters in New York and Pennsylvania. The A(H7N2) virus also spread to an attending veterinarian. In response, 500 cats were transferred from these shelters to a temporary quarantine facility for continued monitoring and treatment. OBJECTIVES: The objectives of this study was to assess the occupational risk of A(H7N2) exposure among emergency response workers at the feline quarantine facility...
May 16, 2018: Influenza and Other Respiratory Viruses
https://www.readbyqxmd.com/read/29768659/influence-of-pregnancy-on-cardiac-function-and-hemodynamics-in-women-with-ebstein-s-anomaly
#11
Miki Kanoh, Kei Inai, Tokuko Shinohara, Eriko Shimada, Mikiko Shimizu, Hirofumi Tomimatsu, Masaki Ogawa, Toshio Nakanishi
INTRODUCTION: We examined the perinatal outcomes and right ventricular function before pregnancy, during pregnancy, and after delivery in women with Ebstein's anomaly. MATERIAL AND METHODS: We retrospectively investigated the clinical course and mode of delivery and monitored hemodynamic parameters throughout pregnancy in 17 women with Ebstein's anomaly, who delivered at our institution during the period of 1995-2015. RESULTS: Eight women, including nine pregnancies, underwent elective cesarean section, and nine women, including 14 pregnancies, underwent vaginal delivery...
May 16, 2018: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/29767544/the-aerobic-resistance-inspiratory-muscle-training-hypothesis-in-heart-failure
#12
Ioannis D Laoutaris
Evidence from large multicentre exercise intervention trials in heart failure patients, investigating both moderate continuous aerobic training and high intensity interval training, indicates that the 'crème de la crème' exercise programme for this population remains to be found. The 'aerobic/resistance/inspiratory (ARIS) muscle training hypothesis in heart failure' is introduced, suggesting that combined ARIS muscle training may result in maximal exercise pathophysiological and functional benefits in heart failure patients...
January 1, 2018: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/29767459/long-term-effects-of-patiromer-for-hyperkalaemia-treatment-in-patients-with-mild-heart-failure-and-diabetic-nephropathy-on-angiotensin-converting-enzymes-angiotensin-receptor-blockers-results-from-amethyst-dn
#13
Bertram Pitt, George L Bakris, Matthew R Weir, Mason W Freeman, Mitja Lainscak, Martha R Mayo, Dahlia Garza, Rezi Zawadzki, Lance Berman, David A Bushinsky
AIMS: Chronic kidney disease (CKD) in heart failure (HF) increases the risk of hyperkalaemia (HK), limiting angiotensin-converting enzyme inhibitor (ACE-I) or angiotensin receptor blocker (ARB) use. Patiromer is a sodium-free, non-absorbed potassium binder approved for HK treatment. We retrospectively evaluated patiromer's long-term safety and efficacy in HF patients from AMETHYST-DN. METHODS AND RESULTS: Patients with Type 2 diabetes, CKD, and HK [baseline serum potassium >5...
May 16, 2018: ESC Heart Failure
https://www.readbyqxmd.com/read/29765615/prognostic-significance-of-repeated-brain-natriuretic-peptide-measurements-after-percutaneous-transluminal-septal-myocardial-ablation-in-patients-with-drug-refractory-hypertrophic-obstructive-cardiomyopathy
#14
Keitaro Akita, Hikaru Tsuruta, Shinsuke Yuasa, Mitsushige Murata, Keiichi Fukuda, Yuichiro Maekawa
Objectives: To evaluate whether repeated brain natriuretic peptide (BNP) measurements after percutaneous transluminal septal myocardial ablation (PTSMA) provide prognostic information regarding the response to PTSMA in patients with drug-refractory hypertrophic obstructive cardiomyopathy (HOCM). Background: Plasma BNP levels are associated with clinical outcomes in patients with HOCM. However, the prognostic value of plasma BNP level changes before and after PTSMA remains unclear...
2018: Open Heart
https://www.readbyqxmd.com/read/29764963/reducing-missed-opportunities-for-influenza-vaccination-in-patients-with-rheumatoid-arthritis-evaluation-of-a-multisystem-intervention
#15
Rachel Broderick, Iazsmin Ventura, Sunoz Soroosh, Lourdes Franco, Jon T Giles
OBJECTIVE: To assess a multimodal intervention for reducing missed opportunities for outpatient influenza vaccination in individuals with rheumatoid arthritis (RA). METHODS: Patients with RA were enrolled from a single center and each rheumatology outpatient visit was tracked for missed opportunities for influenza vaccination, defined as a visit in which an unvaccinated patient without contraindications remained unvaccinated or lacked documentation of vaccine recommendation in the electronic medical record (EMR)...
May 15, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29764808/9-11-firefighters-at-risk-for-multiple-myeloma
#16
(no author information available yet)
The largest study to date of responders to the World Trade Center attacks in New York, NY, on 9/11 reports that exposed firefighters have roughly twice the risk of developing multiple myeloma precursor disease as the general population. Moreover, firefighters who go on to develop multiple myeloma exhibit a younger age of onset and more aggressive disease than is typical.
May 15, 2018: Cancer Discovery
https://www.readbyqxmd.com/read/29763876/mercury-wet-deposition-and-speciated-mercury-air-concentrations-at-rural-and-urban-sites-across-new-york-state-temporal-patterns-sources-and-scavenging-coefficients
#17
Hao Zhou, Chuanlong Zhou, Philip K Hopke, Thomas M Holsen
Measurements of ambient speciated mercury (Hg) concentrations and Hg wet deposition were made at two urban sites (Bronx, NY and Rochester, NY) and one rural site (Potsdam, NY) in New York State in 2013 and 2014 to: 1) determine the factors influencing Hg wet deposition concentrations, 2) identify the contribution of gaseous oxidized Hg (GOM) and particulate bound Hg (PBM) scavenging to Hg wet deposition concentrations, and 3) identify potential source areas associated with high concentration events. The Bronx had the highest mean gaseous elemental Hg (GEM) and GOM concentrations, Rochester had the highest mean PBM and the lowest GOM concentrations, and Potsdam had the lowest mean GEM and PBM concentrations...
May 12, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29762655/longitudinal-physical-activity-patterns-among-older-adults-a-latent-transition-analysis
#18
Stephen J Mooney, Spruha Joshi, Magdalena Cerdá, Gary J Kennedy, John R Beard, Andrew G Rundle
Most epidemiologic studies of physical activity measure either total energy expenditure or engagement in a single activity type, such as walking. These approaches may gloss over important nuances in activity patterns. We performed a latent transition analysis to identify patterns of activity types as well as neighborhood and individual determinants of changes in those activity patterns over two years in a cohort of 2,023 older adult residents of New York City, NY, surveyed between 2011 and 2013. We identified seven latent classes: 1) Mostly Inactive, 2) Walking, 3) Exercise, 4) Household Activities and Walking, 5) Household Activities and Exercise, 6) Gardening and Household Activities, and 7) Gardening, Household Activities, and Exercise...
May 14, 2018: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29761570/radical-pericardiectomy-for-chronic-constrictive-pericarditis
#19
Shahab Nozohoor, Maria Johansson, Bansi Koul, Doris Cunha-Goncalves
BACKGROUND: We studied the impact of radical pericardiectomy on early and long-term patient survival, postoperative New York Heart Association (NYHA) functional class, and left ventricular ejection fraction in patients with chronic constrictive pericarditis compared to a sub-total pericardiectomy. METHODS: From 1991 to 2016, 41 patients underwent pericardiectomy for chronic constrictive pericarditis. Sub-total pericardiectomy was performed in 17 (41%) and radical pericardiectomy in 24 (59%) patients...
May 14, 2018: Journal of Cardiac Surgery
https://www.readbyqxmd.com/read/29761293/stable-but-progressive-nature-of-heart-failure-considerations-for-primary-care-physicians
#20
REVIEW
Inder Anand
Primary care physicians play a significant role in managing heart failure (HF), with the goals of reducing mortality, avoiding hospitalization, and improving patients' quality of life. Most HF-related hospitalizations and deaths occur in patients with New York Heart Association functional class II or III, many of whom are perceived to have stable disease, which often progresses without clinical symptoms due to underlying deleterious effects of neurohormonal imbalance and endothelial dysfunction. Management includes lifestyle changes and stepped pharmacological therapy directed at the four stages of HF, with aggressive uptitration of therapies, including beta-blockers and inhibitors of the renin-angiotensin-aldosterone system...
May 14, 2018: American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions
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