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William Y C Huang, Han-Kuei Chiang, Jay T Groves
Biochemical signaling pathways often involve proteins with multiple, modular interaction domains. Signaling activates binding sites, such as by tyrosine phosphorylation, which enables protein recruitment and growth of networked protein assemblies. Although widely observed, the physical properties of the assemblies, as well as the mechanisms by which they function, remain largely unknown. Here we examine molecular mobility within LAT:Grb2:SOS assemblies on supported membranes by single-molecule tracking. Trajectory analysis reveals a discrete temporal transition to subdiffusive motion below a characteristic timescale, indicating that the LAT:Grb2:SOS assembly has the dynamical structure of a loosely entangled polymer...
October 17, 2017: Biophysical Journal
Chun Lin, Jun Fan, Wenna Liu, Xiaodong Chen, Lijun Ruan, Weiguang Zhang
A new single-urea-bound chiral stationary phase based on 3, 5-dimethylphenyl- carbamoylated β-cyclodextrin was prepared through the Staudinger reaction of mono (6(A) -azido-6(A) -deoxy)-per(3, 5-dimethylphenylcarbamoylated) β-cyclodextrin and 3-aminopropyl silica gel under CO2 atmosphere. The new phase exhibited good enantioseparation performance for 33 analytes using normal-phase HPLC conditions; 19 of them were baseline separated. Effects of structure of analytes, alcoholic modifiers, and acidic/basic additives on separation performances of this new cyclodextrin chiral stationary phase have been studied in detail...
October 17, 2017: Electrophoresis
Yulia V Kochergina, Martin Udatný, Vít Penížek, Martin Mihaljevič
Early efforts at remediation of contaminated soils involve overturn or removal of the uppermost soil horizons. We find that such disruption is counterproductive, as it actually increases the mobility of the heavy metals involved. In our study, we sought to replicate in a controlled manner this commonly used remediation strategy and measure Pb, Zn, Cu and As concentrations in all soil horizons-both prior to and 1 year after disruption by trenching. BCR analyses (sequential leaching) indicate that Pb is affected to the greatest degree and is most highly mobile; however, Zn and As remain insoluble, thus partially ameliorating the detrimental effect...
October 18, 2017: Environmental Monitoring and Assessment
Yangfan Shao, Fang Zhang, Xingqiang Shi, Hui Pan
Two dimensional (2D) nanomaterials have demonstrated huge potential in wide applications from nanodevices to energy harvesting/storage. In this work, we propose a new class of 2D monolayers, nitrogen-functionalized MXenes (Nb2CN2 and Ta2CN2), based on density-functional theory (DFT). We find that these monolayers are direct semiconductors with near linear energy dispersions at the Γ point. M2CN2 monolayers have significant small effective mass and show an ultra-high mobility of up to 10(6) cm(2) V(-1) s(-1)...
October 18, 2017: Physical Chemistry Chemical Physics: PCCP
Ross Shegog, Charles E Begley
INTRODUCTION: Epilepsy is a neurological disorder involving recurrent seizures. It affects approximately 5 million people in the U.S. To optimize their quality of life people with epilepsy are encouraged to engage in self-management (S-M) behaviors. These include managing their treatment (e.g., adhering to anti-seizure medication and clinical visit schedules), managing their seizures (e.g., responding to seizure episodes), managing their safety (e.g., monitoring and avoiding environmental seizure triggers), and managing their co-morbid conditions (e...
2017: Frontiers in Public Health
Blanca Romero-Moraleda, Roy La Touche, Sergio Lerma-Lara, Raúl Ferrer-Peña, Víctor Paredes, Ana Belén Peinado, Daniel Muñoz-García
OBJECTIVES: Compare the immediate effects of a Neurodynamic Mobilization (NM) treatment or foam roller (FR) treatment after DOMS. DESIGN: Double blind randomised clinical trial. SETTING: The participants performed 100 drop jumps (5 sets of 20 repetitions, separated by 2 min rests) from a 0.5-m high box in a University biomechanics laboratory to induce muscle soreness. The participants were randomly assigned in a counter-balanced fashion to either a FR or NM treatment group...
2017: PeerJ
Sonal Batra, Ross A Baker, Tao Wang, Felicia Forma, Faith DiBiasi, Timothy Peters-Strickland
BACKGROUND: As the capabilities and reach of technology have expanded, there is an accompanying proliferation of digital technologies developed for use in the care of patients with mental illness. The objective of this review was to systematically search published literature to identify currently available health technologies and their intended uses for patients with serious mental illness. MATERIALS AND METHODS: The Medline, Embase, and BIOSIS Previews electronic databases were searched to identify peer-reviewed English language articles that reported the use of digital, mobile, and other advanced technology in patients with schizophrenia/schizoaffective disorder, bipolar disorder, and major depressive disorder...
2017: Medical Devices: Evidence and Research
Alexander E Ehret, Kevin Bircher, Alberto Stracuzzi, Vita Marina, Manuel Zündel, Edoardo Mazza
Understanding the mechanisms of deformation of biological materials is important for improved diagnosis and therapy, fundamental investigations in mechanobiology, and applications in tissue engineering. Here we demonstrate the essential role of interstitial fluid mobility in determining the mechanical properties of soft tissues. Opposite to the behavior expected for a poroelastic material, the tissue volume of different collagenous membranes is observed to strongly decrease with tensile loading. Inverse poroelasticity governs monotonic and cyclic responses of soft biomembranes, and induces chemo-mechanical coupling, such that tensile forces are modulated by the chemical potential of the interstitial fluid...
October 17, 2017: Nature Communications
Bastien Béchadergue, Luc Chassagne, Hongyu Guan
Visible light communication (VLC) is an attractive complementary communication technology for vehicular applications such as platooning. Although data rates around 100 kbps are enough for crucial data transmission, it may be useful to reach a few megabits per second for other applications like networking. Such data rates can be reached by using appropriate modulations and clock rates. In this paper, three forms of pulse amplitude modulations (PAM) are compared in a vehicular context: on-off keying (OOK), PAM-4 and generalized space-shift keying (GSSK)...
October 2, 2017: Optics Express
Antoine Pierart, Camille Dumat, Arthur QuyManh Maes, Nathalie Sejalon-Delmas
1. CONTEXT: Urban areas are often contaminated with various forms of persistent metal (loid) and emerging contaminants such as antimony (Sb). Thus, in the context of urban agriculture where sustainable practices such as biofertilizers application (arbuscular mycorrhizal fungi, AMF) could improve nutrient transfer from the soil to the vegetables, the effect of AMF on metal (loid) mobility and human bioaccessibility is still poorly known. 2. METHODS: The role of AMF in Sb uptake by lettuce and carrot grown in artificial substrate spiked with different Sb chemical species was investigated...
October 10, 2017: Chemosphere
Su-Xiang Feng, Xian-He Li, Meng-Meng Wang, Rui Hao, Meng-Meng Li, Lei Zhang, Zhe Wang
A rapid, sensitive and selective method based on high-performance liquid chromatography coupled with Q-Exactive mass spectrometry was developed and validated for simultaneous quantification of thirteen components in rat plasma, including chlorogenic acid, 5-caffeoylquinic acid, 4-caffeoylquinic acid, luteoloside, isochlorogenic acid A, B and C, scutellarin, baicalin, wogonin, baicalein, phillyrin and forsythoside A. After precipitating proteins from the plasma samples with methanol, chromatographic separation of the thirteen components was achieved by using an XBridge™ C18 column (2...
October 13, 2017: Journal of Pharmaceutical and Biomedical Analysis
James N Dodds, Jody C May, John A McLean
Here we examine the relationship between resolving power (Rp), resolution (Rpp), and collision cross section (CCS) for compounds analyzed in previous ion mobility (IM) experiments representing a wide variety of instrument platforms and IM techniques. Our previous work indicated these three variables effectively describe and predict separation efficiency for drift tube ion mobility spectrometry (DTIMS) experiments. In this work we seek to determine if our previous findings are a general reflection of IM behavior applicable to various instrument platforms and mobility techniques...
October 17, 2017: Analytical Chemistry
Mingzhu Yang, Wei Zhang, Wenshu Zheng, Fengjing Cao, Xingyu Jiang
This study reports a simple, rapid, low-cost, robust, and multiplexed barcoded paper-based assay (BPA) compatible with mobile devices. An inkjet printer and an XYZ dispensing platform were used to realize mass-manufacturing of barcoded paper-based analytical devices (BPADs) with high precision and efficiency. We designed a new group of barcodes and developed an application (APP) for the reading of the new code. The new barcodes possess a 16 times higher coding capacity than the standard Codabar code in our experiment on drug residue detection...
October 17, 2017: Lab on a Chip
Snežana Stupar-Rutenfrans, Loes E H Ketelaars, Marnix S van Gisbergen
With this article, we aim to increase our understanding of how mobile virtual reality exposure therapy (VRET) can help reduce speaking anxiety. Using the results of a longitudinal study, we examined the effect of a new VRET strategy (Public Speech Trainer, PST), that incorporates 360° live recorded VR environments, on the reduction of public speaking anxiety. The PST was developed as a 360° smartphone application for a VR head-mounted device that participants could use at home. Realistic anxiety experiences were created by means of live 360° video recordings of a lecture hall containing three training sessions based on graded exposure framework; empty classroom (a) and with a small (b) and large audience (c)...
October 2017: Cyberpsychology, Behavior and Social Networking
Essi Heimovaara-Kotonen, Mari Punna
No abstract text is available yet for this article.
2017: Studies in Health Technology and Informatics
Frederic Ehrler, Johan N Siebert, Jessica Rochat, Franck Schneider, Annick Galetto, Alain Gervaix, Christian Lovis
INTRODUCTION: Patient centred care fosters a holistic approach of care switching the focus from a disease perspective to a patient's experience perspective. Patient centred care is of particular importance in the context of paediatric emergency medicine. Indeed, parents entering a paediatric emergency department (PED) are usually under stress caused by their children's illness, the unfamiliar setting of the PED and delays of care. All these factors can deteriorate their experience as well as the relationships between healthcare providers, the patients and their parents...
2017: Studies in Health Technology and Informatics
Chunyan Jiang, Ting Liu, Chunhua Du, Xin Huang, Mengmeng Liu, Zhenfu Zhao, Linxuan Li, Xiong Pu, Junyi Zhai, Weiguo Hu, Zhong Lin Wang
The piezotronic effect utilizes strain-induced piezoelectric polarization charges to tune the carrier transportation across the interface/junction. We fabricated a high-performance AlGaN/GaN high electron mobility transistor (HEMT), and the transport property was proven to be enhanced by applying an external stress for the first time. The enhanced source-drain current was also observed at any gate voltage and the maximum enhancement of the saturation current was up to 21% with 15 N applied stress (0.18 GPa at center) at -1 V gate voltage...
October 17, 2017: Nanotechnology
Emmmanuel E Awokunmi
The need to develop an approach for the reclamation of contaminated site using locally available agricultural waste has been considered. The present study investigated the application of sawdust as an effective amendment in the immobilization of potentially toxic metals (PTMs) by conducting a greenhouse experiment on soil collected from an automobile dumpsite. The amended and non-amended soil samples were analyzed for their physicochemical parameters and sequential extraction of PTMs. The results revealed that application of amendment had positive impact on the physicochemical parameters as organic matter content and cation exchange capacity increased from 12...
October 16, 2017: Bulletin of Environmental Contamination and Toxicology
Halise B Cagirici, Sezgi Biyiklioglu, Hikmet Budak
Wheat Stem Sawfly (WSS), Cephus Cinctus Norton (Hymenoptera: Cephidae), is one of the most important pests, causing yield and economic losses in wheat and barley. The lack of information about molecular mechanisms of WSS for defeating plant's resistance prevents application of effective pest control strategies therefore, it is essential to identify the genes and their regulators behind WSS infestations. Long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) are recognized with their regulatory functions on gene expression, tuning protein production by controlling transcriptional and post-transcriptional activities...
2017: Frontiers in Plant Science
Khalil M Ahmad Yousef, Bassam J Mohd, Khalid Al-Widyan, Thaier Hayajneh
Extrinsic calibration of a camera and a 2D laser range finder (lidar) sensors is crucial in sensor data fusion applications; for example SLAM algorithms used in mobile robot platforms. The fundamental challenge of extrinsic calibration is when the camera-lidar sensors do not overlap or share the same field of view. In this paper we propose a novel and flexible approach for the extrinsic calibration of a camera-lidar system without overlap, which can be used for robotic platform self-calibration. The approach is based on the robot-world hand-eye calibration (RWHE) problem; proven to have efficient and accurate solutions...
October 14, 2017: Sensors
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