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Tiziana Tosco, Rajandrea Sethi
Nanosized particles (NPs), such as TiO2 , Silver, graphene NPs, nanoscale zero-valent iron, carbon nanotubes, etc., are increasingly used in industrial processes, and releases at production plants and from landfills are likely scenarios for the next years. As a consequence, appropriate procedures and tools to quantify the risks for human health associated to these releases are needed. The tiered approach of the standard ASTM procedure (ASTM-E2081-00) is today the most applied for human health risk assessment at sites contaminated by chemical substances, but it cannot be directly applied to nanoparticles: NP transport along migration pathways follows mechanisms significantly different from those of chemicals; moreover, also toxicity indicators (namely, reference dose and slope factor) are NP-specific...
April 12, 2018: Environmental Pollution
Nesrine Ouadah, Claudine Moire, Fabien Brothier, Jean-François Kuntz, Olivier Deschaume, Carmen Bartic, Hervé Cottet
Aluminum chlorohydrates (ACH) are used in numerous applications and commercial products on a global scale including water treatment, catalysis or antiperspirants. They are complex mixtures of water soluble aluminum polycations of different degrees of polymerization, that are difficult to separate and quantify due to their susceptibility to depolymerize in solution when placed out of equilibrium, which is inherent to any separation process. We recently achieved the first capillary electrophoresis separation and characterization of ACH oligomers using 4-morpholineethanesulfonic acid (MES) as background electrolyte counter-ion...
March 29, 2018: Journal of Chromatography. A
Giulia Ricci, Sigrid Baldanzi, Fabrizio Seidita, Chiara Proietti, Francesca Carlini, Silvia Peviani, Giovanni Antonini, Andrea Vianello, Gabriele Siciliano
In recent years, the potential of smart technology to provide innovative solutions for disease management has raised high expectations for patients' and healthcare professionals' community. We developed a mobile app, called AIGkit, specifically designed for adult patients with Pompe disease, with the aim to help them manage the burden of illness-related factors, and also to provide clinicians with continuous tracking of each patient in real-time and ambient conditions of everyday life. We present the AIGkit as an innovative approach exploiting cutting-edge technology to improve quality of care and research into neuromuscular disorders...
March 12, 2018: Neuromuscular Disorders: NMD
Xiaoyan Qi, Lin Zhao, Qiuping Zhao, Qiaoxia Xu
In this study, a fast, simple and sensitive liquid chromatography-mass spectrometry method was developed for simultaneous determination of crizotinib and its major oxidative metabolite crizotinib-lactam in human plasma. The plasma samples were deproteinated by using acetonitrile containing 0.1% formic acid as precipitant whereas the chromatographic separation was obtained on a C18 column with 0.1% formic acid aqueous and acetonitrile/methanol (v:v, 1:1) as mobile phase. The mass detector was operated in positive selected reaction monitoring mode...
March 28, 2018: Journal of Pharmaceutical and Biomedical Analysis
Andrew Sawers, Brian Hafner
OBJECTIVE: To evaluate the content, construct, and discriminant validity of the Narrowing Beam Walking Test (NBWT), a performance-based balance test for lower limb prosthesis users. DESIGN: Cross-sectional study. SETTING: Research laboratory and prosthetics clinic. PARTICIPANTS: Forty unilateral transtibial and transfemoral prosthesis users. INTERVENTION: Not applicable. MAIN OUTCOME MEASURE(S): Content validity was examined by quantifying the percentage of participants receiving maximum or minimum scores (i...
April 10, 2018: Archives of Physical Medicine and Rehabilitation
Michael Simoni, Hugh S Taylor
PURPOSE OF REVIEW: The current review provides an update on recent advances in stem cell biology relevant to female reproduction. RECENT FINDINGS: Stem cells are undifferentiated cells that often serve as a reservoir of cells to regenerate tissue in settings or injury or cell loss. The endometrium has progenitor stem cells that can replace all of the endometrium during each menstrual cycle. In addition, multipotent endometrial cells replace these progenitor cells when depleted...
April 12, 2018: Current Opinion in Obstetrics & Gynecology
Attrimuni P Dhondge, Pei-Chung Tsai, Chiao-Yun Nien, Wei-Yu Xu, Po-Ming Chen, Yu-Hung Hsu, Kan-Wei Li, Feng-Ming Yen, Shin-Lun Tseng, Yu-Chang Chang, Henry J H Chen, Ming-Yu Kuo
The synthesis, characterization, and application of two angular-shaped naphthalene bis(1,5-diamide-2,6-diylidene)malononitriles (NBAMs) as high-performance air-stable n-type organic field effect transistor (OFET) materials are reported. NBAM derivatives exhibit deep lowest-unoccupied molecular orbital (LUMO) levels, suitable for air-stable n-type OFETs. The OFET device based on NBAM-EH fabricated by vapor deposition exhibits a maximum electron mobility of 0.63 cm2 V-1 s-1 in air with an on/off current ratio ( Ion / Ioff ) of 105 ...
April 13, 2018: Organic Letters
Chloé Vigliotti, Cédric Bicep, Eric Bapteste, Philippe Lopez, Eduardo Corel
Understanding how an animal organism and its gut microbes form an integrated biological organization, known as a holobiont, is becoming a central issue in biological studies. Such an organization inevitably involves a complex web of transmission processes that occur on different scales in time and space, across microbes and hosts. Network-based models are introduced in this chapter to tackle aspects of this complexity and to better take into account vertical and horizontal dimensions of transmission. Two types of network-based models are presented, sequence similarity networks and bipartite graphs...
April 2018: Microbiology Spectrum
Scott W Cheatham
BACKGROUND: In sports medicine, the interprofessional care of athletes has become a frequent practice. This type of care often involves different interventions used among professionals. One common intervention prescribed is roller massage (RM) or self-myofascial release. The trends in the use of RM among allied health professionals is non-existent. The surveillance of such responses has not been documented. PURPOSE: To survey and document responses in the knowledge, clinical application, and use of RM devices among allied health professionals in the United States...
April 13, 2018: Journal of Sport Rehabilitation
Nicole Chiang, Michael Guo, K Rivet Amico, Lou Atkins, Richard T Lester
BACKGROUND: Medication adherence is an important but highly complex set of behaviors, which for life-threatening and infectious diseases such as HIV carry critical consequences for individual and public health. There is growing evidence that mobile phone text messaging interventions (mHealth) connecting providers with patients positively impact medication adherence, particularly two-way engagement platforms that require bidirectional communication versus one-way in which responses are not mandatory...
April 12, 2018: JMIR MHealth and UHealth
J Abdul-Kader, G Airagnes, S D'almeida, F Limosin, A-L Le Faou
Smoking cessation treatments have been proved effective to stop smoking. For pharmacological treatments, nicotine replacement therapies (NRT) as well as bupropion allow to increase 6 month-abstinence rates by more than 80% in comparison with placebo while varenicline prescription doubles success rates in the same conditions. These results mean that for 10 smokers who quit with placebo, 18 are expected to quit with NRT or bupropion and 28 are expected to quit with varenicline. Varenicline is 50% more effective than nicotine patch and 70% more effective than nicotine gum...
April 9, 2018: Revue de Pneumologie Clinique
Arbianingsih, Yossy Utario, Yeni Rustina, Tri Krianto, Dian Ayubi
OBJECTIVE: This research aimed to examine the effectiveness of an Android mobile game application called Arbi Care as a means to prevent diarrhea and build self-efficacy in hand washing among preschool children. METHOD: This research used a pre- and post-test control group and time series design approach. Respondents were chosen randomly from a group of four to six years children. The intervention group (n = 60) received Arbi Care intervention for 25 minutes, twice a week, for five weeks while the control group (n = 60) received standard education...
February 2018: Enfermería Clínica
Marie-Claude Tremblay, Debbie H Martin, Alex M McComber, Amelia McGregor, Ann C Macaulay
BACKGROUND: A longstanding challenge of community-based participatory research (CBPR) has been to anchor evaluation and practice in a relevant theoretical framework of community change, which articulates specific and concrete evaluative benchmarks. Social movement theories provide a broad range of theoretical tools to understand and facilitate social change processes, such as those involved in CBPR. Social movement theories have the potential to provide a coherent representation of how mobilization and collective action is gradually developed and leads to systemic change in the context of CBPR...
April 12, 2018: BMC Public Health
A-Young Lee, Hyun-Soo Ra, Dohyun Kwak, Jeong Min-Hye, Jeong-Hyun Park, Yeon-Su Kang, Weon-Sik Chae, Jong-Soo Lee
Recently, black phosphorus (BP) with direct band gap exhibited excellent potential for optoelectronic applications due to its high charge carrier mobility and low dark current as well as the variable band gap of 0.3 eV to 1.5 eV depending on the number of layers. However, few-layer BP-based phototransistors (photo-FETs) have been limited in sensitivity and wavelength selectivity. To overcome the drawback of these photo-FETs, we studied hybrid photo-FETs combined with the novel properties of the two materials between the channel and sensitizer layers...
April 13, 2018: ACS Applied Materials & Interfaces
Shannon L Wallace, Shailja Mehta, Sara Farag, Robert S Kelley, Katherine T Chen
INTRODUCTION: Thousands of medical applications (apps) are available for mobile devices. Finding accurate, health care provider-centered apps may be time consuming and frustrating for urogynecologists. The objective of this study was to identify and evaluate urogynecology (urogyn) apps using a modified APPLICATIONS scoring system. MATERIALS AND METHODS: Urogyn apps were identified from the Apple iTunes and Google Play Stores using the following 10 MeSH terms: urogynecology, incontinence, prolapse, urinary tract infection, pelvic surgery, fecal incontinence, defecation disorder, voiding disorder, urethral diverticulum, and fistula...
April 11, 2018: Female Pelvic Medicine & Reconstructive Surgery
M Tarallo, P Fino, D Ribuffo, D Casella, M Toscani, C Spalvieri, W Lattanzi, G Di Taranto
BACKGROUND: Although fingertip injuries account for a high proportion of trauma patients, the correct surgical approach is still debated. This prospective study compares the traditional conservative approach and a new treatment based on the injection of liposuction aspirate fluid (LAF). METHODS: 40 consecutive patients with a fingertip injury were dichotomized into group A (control group: conservative approach) and B (treatment group). Group B underwent liposuction, followed by filtration of the lipoaspirate in a closed device (MyStemEvo®kit), allowing the nonenzymatic separation of LAF, which was then injected at injured site...
March 29, 2018: Plastic and Reconstructive Surgery
Frank R Fontaine, Stephen Goodall, Jeremy W Prokop, Christopher B Howard, Mehdi Moustaqil, Somuah Kumble, Daniel T Rasicci, Geoffrey W Osborne, Yann Gambin, Emma Sierecki, Martina L Jones, Johannes Zuegg, Stephen Mahler, Mathias Francois
Antibodies are routinely used to study the activity of transcription factors, using various in vitro and in vivo approaches such as electrophoretic mobility shift assay, enzyme-linked immunosorbent assay, genome-wide method analysis coupled with next generation sequencing, or mass spectrometry. More recently, a new application for antibodies has emerged as crystallisation scaffolds for difficult to crystallise proteins, such as transcription factors. Only in a few rare cases, antibodies have been used to modulate the activity of transcription factors, and there is a real gap in our knowledge on how to efficiently design antibodies to interfere with transcription...
April 12, 2018: MAbs
L Jones, L Lin, T W Chamberlain
Carbon nanomaterials such as polyaromatic hydrocarbons (PAHs), graphene, fullerenes and nanotubes are on the frontline of materials research due to their excellent physical properties, which in recent years, have started to compete with conventional inorganic materials in charge transfer based applications. Recently, a variety of new structures such as single-walled carbon nanobelts (SWCNBs) have been conceived, however, to date only one 'all-phenyl' example has been synthesised, due to problems with their stability and the challenging synthetic methodologies required...
April 12, 2018: Nanoscale
Tomas Torres, Shu Seki, M Victoria Martinez-Diaz, Wakana Matsuda, Hidenori Saeki, Beatriz Urones, Tsuneaki Sakurai, German Zango
A series of peripherally dicyano-, tricyano- and tetracyano- substituted subphthalocyanines (SubPcs) have been prepared via microwave-assisted palladium-mediated cyanation of iodinated precursors. The introduction of π-acceptor cyano groups in the macrocycle clearly influences its electronic and redox properties, which are dependent on the number and relative position of these substituents. Additional functionalization of the SubPcs periphery with electron-donating or electron-withdrawing groups allows for a further fine tune of their features, leading to intensely-absorbing strong-electron-acceptor panchromatic dyes with low-lying LUMO energy levels...
April 12, 2018: Chemistry: a European Journal
Mohammad Shahid, Amaresh Kumar Nayak, Rahul Tripathi, Jawahar Lal Katara, Priyanka Bihari, Banwari Lal, Priyanka Gautam
It is reported that high temperatures (HT) would cause a marked decrease in world rice production. In tropical regions, high temperatures are a constraint to rice production and the most damaging effect is on spikelet sterility. Boron (B) plays a very important role in the cell wall formation, sugar translocation, and reproduction of the rice crop and could play an important role in alleviating high temperature stress. A pot culture experiment was conducted to study the effect of B application on high temperature tolerance of rice cultivars in B-deficient soil...
April 12, 2018: International Journal of Biometeorology
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