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Periorbital hyperpigmentation

Eftychia Platsidaki, Anargyros Kouris, Efthymia Agiasofitou, Christina Antoniou, Georgios Kontochristopoulos
Background: Xanthelasma palpebrarum refers to xanthomas that occur more often near the inner canthus of the eyelid. Periorbital hyperpigmentation presents as a dark area surrounding the eyelids. Objective: In the present study, the authors examined the prevalence and the associated factors of periorbital hyperpigmentation among patients with xanthelasma. Methods: One hundred and fourteen patients with xanthelasma palpebrarum were examined for the presence of dark circles. Detailed questionnaires regarding the history of diabetes, hypothyroidism, smoking status, and weight were completed by all patients...
April 2016: Journal of Clinical and Aesthetic Dermatology
Rashmi Ranjan, Rashmi Sarkar, Vijay Kumar Garg, Tanvi Gupta
BACKGROUND: Periorbital hyperpigmentation (POH) is a common hyperpigmentary problem of the face, which can be psychologically distressing and it can influence an individual's quality of life. However, this condition has received less attention in literature. AIMS AND OBJECTIVES: To study the clinico-etiological features and the effect of two therapeutic modalities on the quality of life in patients of POH before and after treatment. MATERIALS AND METHODS: Fifty patients attending the outpatient clinic of Dermatology Department, with clinically evident POH were included...
July 2016: Indian Journal of Dermatology
Tiffany N S Ballard, César A Briceño
A 20-year-old woman underwent lacrimal gland biopsy for unilateral swelling and was unexpectedly found to have olive-green discoloration of her orbital rim. Postoperative questioning revealed that as a teenager she had been treated for acne with minocycline, a semisynthetic tetracycline antibiotic and a first-line treatment for moderate and severe acne. While hyperpigmentation is a known side effect of minocycline, reports of pigmentation changes of the periorbital bones are relatively rare and could pose a diagnostic dilemma during surgery...
April 2016: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
Rashmi Sarkar, Rashmi Ranjan, Shilpa Garg, Vijay K Garg, Sidharth Sonthalia, Shivani Bansal
Periorbital hyperpigmentation is a commonly encountered condition. There is very little scientific data available on the clinical profile and pathogenesis of periorbital hyperpigmentation. Periorbital hyperpigmentation is caused by various exogenous and endogenous factors. The causative factors include genetic or heredity, excessive pigmentation, postinflammatory hyperpigmentation secondary to atopic and allergic contact dermatitis, periorbital edema, excessive vascularity, shadowing due to skin laxity and tear trough associated with aging...
January 2016: Journal of Clinical and Aesthetic Dermatology
Dibyajyoti Boruah, V Manu, Ajay Malik, Manas Chatterjee, Biju Vasudevan, V Srinivas
BACKGROUND: An increase in number of melanocytes in the basal cell layer of the epidermis is an important feature in many disorders of hyperpigmentation. In this study, we attempted an objective evaluation of the linear density of melanocytes and keratinocytes, along with other epidermal characteristics, in periorbital hyperpigmentation using immunohistochemistry and morphometric techniques. METHODS: Melanocytes and epidermal parameters were assessed by digital morphometry in 30 newly diagnosed cases of periorbital hyperpigmentation and 14 controls from the post-auricular region...
November 2015: Indian Journal of Dermatology, Venereology and Leprology
Seung Jae Lee, Jung-In Kim, You Jin Yang, Jae Hui Nam, Won-Serk Kim
BACKGROUND: Periorbital wrinkles as a result of photoaging are a frequent cosmetic concern. Recently, the fractional radiofrequency microneedle system was introduced as a new device for facial rejuvenation, and it has received much recognition for its unique "deep dermal heating with epidermal sparing" feature. OBJECTIVE: The purpose of this study was to examine the clinical efficacy and safety of the system for the treatment of periorbital wrinkles in Korean patients...
May 2015: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
Patricia Farris, Margarita Yatskayer, Nannan Chen, Yevgeniy Krol, Christian Oresajo
Resveratrol is an effective anti-aging molecule with diverse biologic activity. It functions as a dual antioxidant that can neutralize free radicals and increase intrinsic antioxidant capacity. Additionally resveratrol increases mitochondrial biogenesis and has anti-inflammatory, anti-diabetic, and anti-cancer activity. In this paper we will focus on the use of topically applied resveratrol using a proprietary blend containing 1% resveratrol, 0.5% baicalin, and 1% vitamin E. This stabilized high concentration formulation demonstrates percutaneous absorption and alterations in gene expression such as hemoxygenase-1 (HO-1), vascular endothelial growth factor (VEGFA), and collagen 3 (COL3A1)...
December 2014: Journal of Drugs in Dermatology: JDD
Ugur Keklikci, Izzet Yavuz, Selcuk Tunik, Zelal Baskan Ulku, Sedat Akdeniz
BACKGROUND: Ectodermal dysplasia (ED) is a disorder that results from abnormal formation of at least two of the four major ectodermal derivatives in the developing embryo. The ectoderm of the embryo forms the skin, teeth, hair and nails, sweat glands and part of the eyes. OBJECTIVES: The aim of this article is to reveal ophthalmologic symptoms and signs as multidisciplinary, reliable criteria for ectodermal dysplasia. MATERIAL AND METHODS: In this retrospective study, 24 patients with ED were analyzed from the recorded data...
July 2014: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
Chun Pil Choi, Seon Mi Yim, Soo Hong Seo, Hyo Hyun Ahn, Young Chul Kye, Jae Eun Choi
BACKGROUND: Despite the effectiveness of low-fluence Q-switched Nd:YAG laser (QSNY) treatment in melasma, adverse events, including mottled hypopigmentation (MH) and rebound hyperpigmentation (RH) have been reported. OBJECTIVE: To compare the effectiveness and safety of combination therapy using low-fluence QSNY and long-pulse Nd:YAG laser (LPNY) (Dual toning), with low-fluence QSNY monotherapy (QS toning), in Asian melasma patients. MATERIALS AND METHODS: Patients were treated for 10 sessions at 1-week intervals with QSNY (6 mm spot); 2...
February 2015: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
Kanika Sahni, Vishal Gupta, Neena Khanna
Vitiligo is an acquired pigmentary disorder, clinically characterized by depigmented macules caused by destruction of melanocytes in the affected skin. Half of all patients develop the disease in childhood and adolescence before the age of 20 years, making vitiligo an important skin disease of childhood. There are numerous studies in the literature that suggest the efficacy of topical tacrolimus in vitiligo, without serious adverse effects. We describe a case of vitiligo in a pediatric patient who developed hyperpigmentation in the periorbital lesions of vitiligo with the use of topical tacrolimus...
April 2014: Indian Dermatology Online Journal
Wendy E Roberts
Periorbital hyperpigmentation (POH) is a common worldwide problem. It is challenging to treat, complex in pathogenesis, and lacking straightforward and repeatable therapeutic options. It may occur in the young and old, however the development of dark circles under the eyes in any age is of great aesthetic concern because it may depict the individual as sad, tired, stressed, and old. While "dark circles" are seen in all skin types, POH is often more commonly seen in skin of color patients worldwide. With a shifting US demographic characterized by growing number of aging patients as well as skin of color patients, we will encounter POH with greater frequency...
April 2014: Journal of Drugs in Dermatology: JDD
Kristin Burger, Anne-Theres Schneider, Sigrun Wohlfart, Franklin Kiesewetter, Kenneth Huttner, Ramsey Johnson, Holm Schneider
X-linked hypohidrotic ectodermal dysplasia (XLHED), the most frequent form of ectodermal dysplasia, is a genetic disorder of ectoderm development characterized by malformation of multiple ectodermal structures such as skin, hair, sweat and sebaceous glands, and teeth. The disease is caused by a broad spectrum of mutations in the gene EDA. Although XLHED symptoms show inter-familial and intra-familial variability, genotype-phenotype correlation has been demonstrated with respect to sweat gland function. In this study, we investigated to which extent the EDA genotype correlates with the severity of XLHED-related skin and hair signs...
October 2014: American Journal of Medical Genetics. Part A
Pratik B Sheth, Hiral A Shah, Jayendra N Dave
BACKGROUND: Periorbital hyperpigmentation (POH) is one of the most commonly encountered conditions in routine dermatology practice. There are only few published studies about its prevalence, classification, and pathogenesis but none showing its association with habits, and other medical conditions in Indian patients. AIMS: To determine prevalence and type of POH, common causative factors, and its association with personal habits and other disorders within various age and sex groups...
March 2014: Indian Journal of Dermatology
Pedram Mehryan, Hamed Zartab, Ali Rajabi, Neda Pazhoohi, Alireza Firooz
BACKGROUND: Infraorbital skin hyperpigmentation, commonly called dark circles, and crow's feet wrinkles are common cosmetic concerns. Various methods of treatment have been evaluated with variable outcomes. OBJECTIVE: This study was performed to assess the efficacy of platelet-rich plasma (PRP) injection for treating periorbital dark circles and crow's feet. METHODS: Ten participants with a mean age of 41.2 years were treated in a single session with intradermal injections of 1...
March 2014: Journal of Cosmetic Dermatology
Tania Ferreira Cestari, Lia Pinheiro Dantas, Juliana Catucci Boza
Cutaneous hyperpigmentations are frequent complaints, motivating around 8.5% of all dermatological consultations in our country. They can be congenital, with different patterns of inheritance, or acquired in consequence of skin problems, systemic diseases or secondary to environmental factors. The vast majority of them are linked to alterations on the pigment melanin, induced by different mechanisms. This review will focus on the major acquired hyperpigmentations associated with increased melanin, reviewing their mechanisms of action and possible preventive measures...
January 2014: Anais Brasileiros de Dermatologia
C Lane Anzalone, Philip R Cohen, Razelle Kurzrock, Jorge E Cortes
BACKGROUND: Imatinib mesylate is a selective tyrosine kinase inhibitor used in the treatment of chronic myelogenous leukemia. Ocular side effects of imatinib include periorbital edema, which may become so severe as to obstruct the visual field. PURPOSE: The purpose of this case study is to describe the clinical characteristics of imatinib- induced postoperative periorbital purpura. MATERIALS AND METHODS: We retrospectively reviewed the medical literature using PubMed, searching the terms edema, Gleevec, imatinib, periorbital, postoperative and purpura...
January 2014: Dermatology Online Journal
Shadman Nemati, Javad Golchay, Arsalan Alizadeh
INTRODUCTION: High prevalence of rhinoplasty in the community and lack of structured studies about its minor skin and soft tissue complications, point out the necessity of performing precise and comprehensive studies. The aim of this study was to determine the frequency of minor cutaneous and soft tissue complications of rhinoplasty. MATERIALS AND METHODS: 110 patients (30 Male and 80 Female, Mean age: 26.3± 6.8) participated in this study. Before surgery all of them were checked for having each of intended complications, and 1 and 3 months after the surgery, they underwent serial visits for monitoring skin & soft tissue complications...
2012: Iranian Journal of Otorhinolaryngology
Charitomeni Vavouli, Andreas Katsambas, Stamatis Gregoriou, Anca Teodor, Carmen Salavastru, Adina Alexandru, George Kontochristopoulos
BACKGROUND: Periorbital dark circles are relatively common, affecting individuals regardless of age, sex, and race. Available treatment includes bleaching creams, topical retinoid acid, chemical peels, laser therapy, autologous fat transplantation - injectable fillers, surgery (blepharoplasty), and chemical peeling. OBJECTIVE: To evaluate the efficacy of a combination of trichloroacetic TCA 3.75% and lactic acid 15% on improving the periorbital hyperpigmentation...
September 2013: Journal of Cosmetic Dermatology
Laxman Besra, Telanseri J Jaisankar, Devinder Mohan Thappa, Munisamy Malathi, Rashmi Kumari
BACKGROUND: Periorbital dermatoses are very common dermatological disorders which pose a diagnostic and therapeutic challenge for the treating dermatologist due to the similarity of symptoms in this area. AIMS: To study the spectrum of periorbital dermatoses and to assess the association of systemic diseases with periorbital dermatoses. METHODS: This was a hospital based descriptive study done on 250 consecutive patients irrespective of their age and sex who attended the Dermatology out patient department (OPD), with dermatological conditions pertaining to the periorbital area over a period of 2 years from October 2010 to September 2012...
May 2013: Indian Journal of Dermatology, Venereology and Leprology
Antonio Carmo Graziosi, Marina Rodrigues Quaresma, Nilceo Schwery Michalany, Lydia Masako Ferreira
BACKGROUND: Dark circles under or around the eyes is a cosmetic problem for a large number of people. It is a condition of unknown etiology characterized by the darkening of the eyelids and periorbital skin. The aim of this study was to determine histopathological changes associated with cutaneous idiopathic hyperchromia of the orbital region (CIHOR). METHODS: Twenty-eight adult patients with CIHOR were consecutively selected for the study. Biopsy specimens were taken from the darkened skin of the eyelid and from the normal retroauricular skin as a control...
April 2013: Aesthetic Plastic Surgery
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