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https://www.readbyqxmd.com/read/28077491/sphingosine-1-phosphate-lyase-deficiency-causes-charcot-marie-tooth-neuropathy
#1
Derek Atkinson, Jelena Nikodinovic Glumac, Bob Asselbergh, Biljana Ermanoska, David Blocquel, Regula Steiner, Alejandro Estrada-Cuzcano, Kristien Peeters, Tinne Ooms, Els De Vriendt, Xiang-Lei Yang, Thorsten Hornemann, Vedrana Milic Rasic, Albena Jordanova
OBJECTIVE: To identify the unknown genetic cause in a nuclear family with an axonal form of peripheral neuropathy and atypical disease course. METHODS: Detailed neurologic, electrophysiologic, and neuropathologic examinations of the patients were performed. Whole exome sequencing of both affected individuals was done. The effect of the identified sequence variations was investigated at cDNA and protein level in patient-derived lymphoblasts. The plasma sphingoid base profile was analyzed...
January 11, 2017: Neurology
https://www.readbyqxmd.com/read/28076542/-dental-decay-in-5-year-old-children-sociodemographic-factors-monitoring-points-and-parental-attitudes
#2
Vinícius Humberto Nunes, Gimol Benzaquen Perosa
Dental decay affects many children, especially those from the lower socioeconomic classes. In this cross-sectional study designed to investigate the role played by sociodemographic factors, parental attitudes, and monitoring points, which are an indicator of personal perception of what controls individual health, on the prevalence of tooth decay among 5-year-old pre-school children living in a midsized city in São Paulo, Brazil. The ceo-d index of 426 children was assessed; the parents reported sociodemographic characteristics and completed two questionnaires concerning monitoring points and parental attitudes...
January 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28076495/antimicrobial-activity-of-ozone-and-naf-chlorhexidine-on-early-childhood-caries
#3
Marcos Ximenes, Mariane Cardoso, Fernando Astorga, Roland Arnold, Luiz André Pimenta, Ricardo de Sousa Viera
An early childhood carie (ECC) is an extremely destructive form of tooth decay. The aim of this study was to investigate the action of ozone (O3), and the association of sodium fluoride (NaF) with chlorhexidine (CHX) on bacteria related to ECC. Overnight culture of the bacteria was performed. On exponential phase the suspension was adjusted (101-108 CFU/mL). A drop (10μL) of each concentration of bacteria was applied on sheep blood agar plates and treated with O3 (2, 20, 200, and 2,000 ppm); after 18 hours, recovery analysis of CFU verified the reduction of bacterial activity...
January 5, 2017: Brazilian Oral Research
https://www.readbyqxmd.com/read/28057060/u-shaped-association-between-untreated-caries-and-body-mass-index-in-adults-at-rabat-dental-university-hospital-morocco-cross-sectional-study
#4
Sanaa Chala, Manal El Aidouni, Redouane Abouqal, Faïza Abdallaoui
BACKGROUND: Many previous studies estimating the relationship between body mass index (BMI) and dental decay are conflicting. Most studies, however, examine the relationship using BMI as a categorical variable. This study evaluated the non-linear association between body mass index as a continuous variable and untreated dental decay. METHODS: Cross-sectional study of adults free of diseases attending a tertiary dental clinic was conducted. The number of untreated caries at the time of consultation was assessed using the WHO criteria...
January 3, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28052212/caries-prevalence-in-korean-children-and-adolescents-from-2000-to-2012
#5
Ah-Hyeon Kim, Youn-Soo Shim, Jong-Bin Kim, So-Youn An
OBJECTIVES: National oral health data is required to assess a population's oral health needs, monitor oral health, plan effective intervention community programs and health policies, and evaluate progress toward health objectives. The study aimed to estimate the prevalence, severity, and inequality in dental caries distribution among Korean young people. STUDY DESIGN: Trained, calibrated examiners at the Korea Ministry of Health & Welfare conducted epidemiological surveys in 2000, 2006, and 2012 during which dental caries were assessed according to World Health Organization (WHO) diagnostic criteria...
2017: Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/28049966/five-year-longitudinal-study-of-dental-caries-risk-associated-with-streptococcus-mutans-and-streptococcus-sobrinus-in-individuals-with-intellectual-disabilities
#6
Yuki Oda, Fumiko Hayashi, Atsuko Wakita, Yukiko Nagatani, Mitsugi Okada
Streptococcus mutans (S. mutans) and Streptococcus sobrinus (S. sobrinus) are important etiologic agents in human dental caries. Using quantitative real-time polymerase chain reaction assays for the presence of those strains, we examined 145 outpatients with intellectual disability (ID), calculated the proportion of each of these strains to total bacteria, and compared dental caries incidence over 5 years. Plaque samples were collected from all erupted tooth sites, and dental examinations were performed annually to determine numbers of decayed, missing, and filled teeth (DMFT score; World Health Organization caries diagnostic criteria)...
December 28, 2016: Journal of Oral Science
https://www.readbyqxmd.com/read/28045314/efficacy-of-a-casein-phosphopeptide-amorphous-calcium-phosphate-cpp-acp-paste-in-preventing-white-spot-lesions-in-patients-with-fixed-orthodontic-appliances-a-prospective-clinical-trial
#7
E Esenlik, E Uzer Çelik, E Bolat
AIM: The aim of this prospective study was to test the efficacy of casein phosphopeptide amorphous calcium phosphate (CPP-ACP) paste applied in-office to prevent white spot lesions (WSL) in patients undergoing fixed orthodontic treatment. MATERIALS AND METHODS: Study design: this study was designed as a randomised controlled clinical trial. Fifty-seven patients undergoing nonextraction fixed orthodontic treatment were enrolled and divided randomly into two groups (control n = 28, experimental n = 29)...
December 2016: European Journal of Paediatric Dentistry: Official Journal of European Academy of Paediatric Dentistry
https://www.readbyqxmd.com/read/28045312/black-stains-a-microbiological-analysis-and-a-view-on-familiarity-and-susceptibility-to-tooth-decay-of-patients-in-childhood
#8
D Tripodi, D Martinelli, M Pasini, M R Giuca, S D'Ercole
AIM: Assess prevalence, familial predisposition and susceptibility to caries of Black Stains (BS). Evaluate the microbiological composition of BS, saliva and subgingival plaque. MATERIALS AND METHODS: Sixty nine subjects with BS (test group) and 120 subjects without BS (control group) were analysed for oral status. For each BS-patient, a BS-deposit, 1 ml of saliva and subgingival plaque were collected and microbiologically analysed. Five deciduous teeth with BS were observed under SEM...
December 2016: European Journal of Paediatric Dentistry: Official Journal of European Academy of Paediatric Dentistry
https://www.readbyqxmd.com/read/28025444/histological-evaluation-of-three-techniques-for-caries-removal
#9
Etienne Medioni, Jean-Paul Rocca, Carlo Fornaini, Elisabetta Merigo
A number of concepts and devices have been proposed for caries removal. Among these, the Er:YAG laser is a potential alternative to conventional mechanical treatment. This study compared the effectiveness of the Er:YAG laser with that of low-speed rotary instruments for removal of carious tissue in 26 extracted human molars and premolars with severe decay (i.e., large occlusal or proximal decay but no pulpal contact). The teeth were divided into three groups of eight teeth, and two teeth were used as controls...
2016: Journal of Oral Science
https://www.readbyqxmd.com/read/28011091/-oral-care-recommendations-for-patients-with-oral-autoimmune-bullous-diseases
#10
V Sobocinski, S-M Dridi, C Bisson, S Jeanne, F Gaultier, C Prost-Squarcioni, P Bernard, F Pascal, B Lefevre, P Weber, C Abasq, S Agbo-Godeau, P Joly, S Ingen-Housz-Oro, S Duvert-Lehembre
BACKGROUND: Autoimmune bullous diseases (AIBD) may cause chronic oral lesions that progress insidiously. AIMS: To provide recommendations for optimal oral-dental management of patients presenting AIBD with oral involvement. PATIENTS AND METHODS: In the absence of scientific studies with high levels of proof, these recommendations have been drawn up at two meetings by a committee of experts on AIBD comprising 7 dermatologists, 1 stomatologist, 1 maxillofacial surgeon, 2 odontologists and 4 parodontologists...
December 20, 2016: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/28000851/three-dimensional-simulated-microgravity-culture-improves-the-proliferation-and-odontogenic-differentiation-of-dental-pulp-stem-cell-in-plga-scaffolds-implanted-in-mice
#11
Yanping Li, Lina He, Shuang Pan, Lin Zhang, Weiwei Zhang, Hong Yi, Yumei Niu
Tooth regeneration through stem cell-based therapy is a promising treatment for tooth decay and loss. Human dental pulp stem cells (hDPSCs) have been widely identified as the stem cells with the most potential for tooth tissue regeneration. However, the culture of hDPSCs in vitro for tissue engineering is challenging, as cells may proliferate slowly or/and differentiate poorly in vivo. Dynamic three‑dimensional (3D) simulated microgravity (SMG) created using the rotary cell culture system is considered to an effective tool, which contributes to several cell functions...
December 14, 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27979302/3-6-anhydro-l-galactose-a-rare-sugar-from-agar-a-new-anticariogenic-sugar-to-replace-xylitol
#12
Eun Ju Yun, Ah Reum Lee, Jung Hyun Kim, Kyung Mun Cho, Kyoung Heon Kim
The significance for anticariogenic sugar substitutes is growing due to increasing demands for dietary sugars and rising concerns of dental caries. Xylitol is widely used as an anticariogenic sugar substitute, but the inhibitory effects of xylitol on Streptococcus mutans, the main cause of tooth decay, are exhibited only at high concentrations. Here, the inhibitory effects of 3,6-anhydro-l-galactose (AHG), a rare sugar from red macroalgae, were evaluated on S. mutans, in comparison with those of xylitol. In the presence of 5g/l of AHG, the growth of S...
April 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27966774/primary-oral-health-care-a-missing-link-in-public-health-in-pakistan
#13
S Basharat, B T Shaikh
In Pakistan, the limited availability of oral health care and the high level of unmet oral health care needs are well documented. The recorded prevalence of dental caries is 50-70% and that of oral cancer is among the highest in the world. Although oral health care has been declared to be part of the primary health care system, oral health disparities between rich and poor, and emerging problems of access to and use of appropriate care have never been addressed, reflecting a lack of awareness among both patients and health system decisionmakers...
December 12, 2016: Eastern Mediterranean Health Journal, la Revue de Santé de la Méditerranée Orientale
https://www.readbyqxmd.com/read/27965502/study-of-caries-prevalence-among-miswak-and-non-miswak-users-a-prospective-study
#14
Mohammed Mustafa, Zaid AlJeaidi, Wafa Hassan AlAajam, Kawthar Ahmed Dafaalla Mohammed
INTRODUCTION: Various types of oral hygiene measures have been practiced by different populations around the world, as there is difference in the oral hygiene products including toothpicks and toothpowders. Miswak or tooth cleaning stick, for mechanical tooth cleaning, can be traced back at least to pre-Islamic times. Currently, many of the world populations still use chewing sticks as the single method for tooth brushing. The present study was done to study the incidence and prevalence of caries among Miswak and non-Miswak users...
November 1, 2016: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/27957268/evaluation-of-mineral-content-in-healthy-permanent-human-enamel-by-raman-spectroscopy
#15
Anna Akkus, Asya Akkus, Renato Roperto, Ozan Akkus, Thiago Porto, Sorin Teich, Lisa Lang
BACKGROUND: An understanding of tooth enamel mineral content using a clinically viable method is essential since variations in mineralization may serve as an early precursor of a dental health issues, and may predict progression and architecture of decay in addition to assessing the success and effectiveness of the remineralization strategies. MATERIAL AND METHODS: Twenty two human incisor teeth were obtained in compliance with the NIH guidelines and site specifically imaged with Raman microscope...
December 2016: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/27935024/risk-factors-for-dental-caries-among-children-with-cerebral-palsy-in-a-low-resource-setting
#16
Rahena Akhter, Nur Mohammad Monsur Hassan, Elizabeth F Martin, Mohammad Muhit, Raziur Rahman, Hayley Smithers-Sheedy, Cheryl Jones, Nadia Badawi, Gulam Khandaker
AIM: To describe the oral health status and investigate factors affecting dental caries experience among children with cerebral palsy (CP) in rural Bangladesh. METHOD: A cross-sectional study was conducted among children with CP who are part of the Bangladesh Cerebral Palsy Register (BCPR) study. Caries experience was measured by identifying decayed, missing, and filled teeth for deciduous and permanent teeth (dmft/DMFT). Clinical periodontal index, body mass index, oral hygiene behaviour, masticatory ability, and dietary habits were recorded...
December 9, 2016: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/27924596/methods-to-study-antagonistic-activities-among-oral-bacteria
#17
Fengxia Qi, Jens Kreth
Most bacteria in nature exist in multispecies communities known as biofilms. In the natural habitat where resources (nutrient, space, etc.) are usually limited, individual species must compete or collaborate with other neighboring species in order to perpetuate in the multispecies community. The human oral cavity is colonized by >700 microbial species known as the indigenous microbiota. This indigenous flora normally maintains an ecological balance through antagonistic as well as mutualistic interspecies interactions...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27920312/dental-care-and-medicare-beneficiaries-access-gaps-cost-burdens-and-policy-options
#18
Amber Willink, Cathy Schoen, Karen Davis
Despite the wealth of evidence that oral health is related to physical health, Medicare explicitly excludes dental care from coverage, leaving beneficiaries at risk for tooth decay and periodontal disease and exposed to high out-of-pocket spending. To profile these risks, we examined access to dental care across income groups and types of insurance coverage in 2012. High-income beneficiaries were almost three times as likely to have received dental care in the previous twelve months, compared to low-income beneficiaries-74 percent of whom received no dental care...
December 1, 2016: Health Affairs
https://www.readbyqxmd.com/read/27920308/expanded-scopes-of-practice-for-dental-hygienists-associated-with-improved-oral-health-outcomes-for-adults
#19
Margaret Langelier, Tracey Continelli, Jean Moore, Bridget Baker, Simona Surdu
Dental hygienists are important members of the oral health care team, providing preventive and prophylactic services and oral health education. However, scope-of-practice parameters in some states limit their ability to provide needed services effectively. In 2001 we developed the Dental Hygiene Professional Practice Index, a numerical tool to measure the state-level professional practice environment for dental hygienists. We used the index to score state-level scopes of practice in all fifty states and the District of Columbia in 2001 and 2014...
December 1, 2016: Health Affairs
https://www.readbyqxmd.com/read/27913659/formative-research
#20
Tracy L Finlayson, Padideh Asgari, Lisa Hoffman, Ana Palomo-Zerfas, Martha Gonzalez, Nannette Stamm, Maria-Isabel Rocha, Arcela Nunez-Alvarez
Oral health is a leading unmet health need among migrant families. This article describes the 1-year, community-based participatory research (CBPR) approach employed to plan and develop a Líder Communitario (lay community health worker)-led educational intervention for Mexican migrant adult caregivers and their families in three underserved, remote communities in North San Diego County, California. Four partner organizations collaborated, reviewed existing oral health curricula, and sought extensive input on educational topics and research design from key informants, migrant caregivers, and Líderes Communitarios...
December 1, 2016: Health Promotion Practice
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