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https://www.readbyqxmd.com/read/29457125/enhanced-differentiation-of-dental-pulp-cells-cultured-on-microtubular-polymer-scaffolds-in-vitro
#1
Morteza Haeri, Karen Sagomonyants, Mina Mina, Liisa T Kuhn, A Jon Goldberg
Dental caries (tooth decay) is the most common chronic disease. Dental tissue engineering is a promising alternative approach to alleviate the shortcomings of the currently available restorative materials. Mimicking the natural extracellular matrix (ECM) could enhance the performance of tissue engineering scaffolds. In this study, we developed microtubular (~20 μm diameter) polymethyl methacrylate (PMMA) scaffolds resembling the tubular (~2.5 μm diameter) structure of dentin, the collagen-based mineralized tissue that forms the major portion of teeth, to study the effect of scaffold architecture on differentiation of mouse dental pulp cells in vitro ...
June 2017: Regenerative Engineering and Translational Medicine
https://www.readbyqxmd.com/read/29454320/obesity-and-caries-in-four-to-six-year-old-english-children-a-cross-sectional-study
#2
Martha Paisi, Elizabeth Kay, Irene Kaimi, Robert Witton, Robert Nelder, Ruth Potterton, Debra Lapthorne
BACKGROUND: Obesity and caries are common conditions in childhood and can have significant implications on children's wellbeing. Evidence into their association remains conflicting. Furthermore, studies examining the ssociation between obesity and caries commonly focus on individual-level determinants. The present study aimed to examine the association between obesity and caries in young English children and to determine the impact of deprivation and area-level characteristics on the distribution of the two conditions...
February 17, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29436016/identification-of-caries-risk-in-2-year-olds
#3
Tove Irene Wigen, Christine Sophie Baumgartner, Nina Johanne Wang
OBJECTIVE: The first aim was to describe presence of plaque, caries and oral health behaviours in 2-year-old children. The second aim was to measure increments in caries experience from 2 to 5 years of age and to study whether national background, visible plaque, caries and oral health behaviour at 2 years of age were associated with increments in caries experience. METHODS: The study population consisted of 392 children, of whom 211 were monitored from 2 to 5 years of age...
February 13, 2018: Community Dentistry and Oral Epidemiology
https://www.readbyqxmd.com/read/29435491/genomewide-identification-of-essential-genes-and-fitness-determinants-of-streptococcus-mutans-ua159
#4
Robert C Shields, Lin Zeng, David J Culp, Robert A Burne
Transposon mutagenesis coupled with next-generation DNA sequencing (Tn-seq) is a powerful tool for discovering regions of the genome that are required for the survival of bacteria in different environments. We adapted this technique to the dental caries pathogen Streptococcus mutans UA159 and identified 11% of the genome as essential, with many genes encoding products required for replication, translation, lipid metabolism, and cell wall biogenesis. Comparison of the essential genome of S. mutans UA159 with those of selected other streptococci for which such information is available revealed several metabolic pathways and genes that are required in S...
January 2018: MSphere
https://www.readbyqxmd.com/read/29434225/mechanical-stretch-induced-osteogenic-differentiation-of-human-jaw-bone-marrow-mesenchymal-stem-cells-hjbmmscs-via-inhibition-of-the-nf-%C3%AE%C2%BAb-pathway
#5
Xiaoyan Chen, Yuan Liu, Wanghui Ding, Jiejun Shi, Shenglai Li, Yali Liu, Mengjie Wu, Huiming Wang
Severe malocclusion can contribute to several serious dental and physical conditions, such as digestive difficulties, periodontal disease, and severe tooth decay. Orthodontic treatment is mainly used to treat malocclusion. Forces in orthodontic tooth results in bone resorption on the pressure side and bone deposition on the tension side. Osteoblasts have been considered as the key component in bone regeneration on the tension side. However, the underlying mechanisms remain unclear. In this study, we focus on how mechanical stretch regulates the osteogenesis during orthodontic treatment...
February 12, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29433628/callus-induction-and-somatic-embryogenesis-in-stevia-rebaudiana-bertoni-as-a-medicinal-plant
#6
Tahereh Keshvari, Abdollah Najaphy, Danial Kahrizi, Alireza Zebarjadi
Stevia rebaudiana (Bert.) from Asteraceae family is a useful medicinal plant that prevents and cures diabetes, blood pressure, weight gain and tooth decay. Due to self-incompatibility in stevia, somatic embryo investigation for artificial seed production is valuable in this plant. In order to evaluate the callus induction characteristics in stevia, a factorial experiment was laid out based on a completely randomized design with three replications. The factors included ten hormone combinations and control, two kinds of media (MS and B5) and two types of explants (leaf and internode)...
February 10, 2018: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/29416142/adjusted-fluoride-concentrations-and-control-ranges-in-34-states-2006-2010-and-2015
#7
Laurie K Barker, Kip K Duchon, Srdjan Lesaja, Valerie A Robison, Scott M Presson
To inform selection of a control range around the Public Health Service's recommended 0.7 mg/L drinking water fluoride concentration to prevent tooth decay, CDC's Water Fluoridation Reporting System data for 2006-2010 and 2015 were analyzed. Monthly average concentration data from 4,251 fluoride-adjusted community water systems for 191,266 of 255,060 system-months (2006-2010) were compared to control ranges 0.6 mg/L to 0.2 mg/L wide. Percentages of system-months within control ranges ≥0.4 mg/L wide (e.g., ±0...
August 2017: Journal—American Water Works Association
https://www.readbyqxmd.com/read/29415972/synthesis-of-hybrid-copper-chitosan-nanoparticles-with-antibacterial-activity-against-cariogenic-streptococcus-mutans
#8
Cristian Covarrubias, Diego Trepiana, Camila Corral
Hybrid nanoparticles (CuChNP) comprising of copper nanoparticles with a chitosan shell were synthesized. Antimicrobial properties of CuChNP were assessed against Streptococcus mutans (S. mutans), one of the main bacterium that causes tooth decay. Antibacterial activity of CuChNP against S. mutans was comparable to that of oral antimicrobial agents, such as chlorhexidine, and cetylpyridinium chloride. Particularly, CuChNP exhibited superior capacity to prevent the S. mutans growth on human tooth surface as well as disrupt and kill the bacterial cells in an established dental biofilm...
February 8, 2018: Dental Materials Journal
https://www.readbyqxmd.com/read/29412250/susceptibility-of-cariogenic-microorganisms-to-phytoconstituents
#9
G L S Ferreira, L M D Bezerra, I L A Ribeiro, R C D Morais Júnior, R D Castro
This study aimed to evaluate the in vitro antibacterial activity of the phytochemicals thymol, linalool, and citronellol against Streptococcus mutans, Streptococcus salivarius and Streptococcus oralis. Disk diffusion screening on solid medium and measurement of the diameter of the bacterial growth inhibition halos was the technique utilized. The Minimum Inhibitory Concentration (MIC) of the substances was determined using serial substance dilutions and microdilution technique in Brain Heart Infusion culture medium...
February 1, 2018: Brazilian Journal of Biology, Revista Brasleira de Biologia
https://www.readbyqxmd.com/read/29410771/inhibition-of-steptococcus-mutans-biofilm-formation-by-extracts-of-tenacibaculum-sp-20j-a-bacterium-with-wide-spectrum-quorum-quenching-activity
#10
Andrea Muras, Celia Mayer, Manuel Romero, Tamara Camino, Maria D Ferrer, Alex Mira, Ana Otero
Background: Previous studies have suggested the quorum sensing signal AI-2 as a potential target to prevent the biofilm formation by Streptococcus mutans, a pathogen involved in tooth decay. Objective: To obtain inhibition of biofilm formation by S. mutans by extracts obtained from the marine bacterium Tenacibaculum sp. 20J interfering with the AI-2 quorum sensing system. Design: The AI-2 inhibitory activity was tested with the biosensors Vibrio harveyi BB170 and JMH597. S. mutans ATCC25175 biofilm formation was monitored using impedance real-time measurements with the xCELLigence system®, confocal laser microscopy, and the crystal violet quantification method...
2018: Journal of Oral Microbiology
https://www.readbyqxmd.com/read/29405300/evidence-of-effectiveness-of-preventive-dental-care-in-reducing-dental-treatment-use-and-related-expenditures
#11
Nadereh Pourat, Moonkyung Kate Choi, Xiao Chen
OBJECTIVES: Preventive dental health services are intended to reduce the likelihood of development of tooth decay and the need for more intensive treatment overtime. The evidence on the effectiveness of preventive dental care in reducing treatment services and expenditures is lagging for adults, particularly those with lower incomes and chronic conditions. We assessed the impact of preventive dental services on dental treatment service use and expenditures overall and by category of service...
February 6, 2018: Journal of Public Health Dentistry
https://www.readbyqxmd.com/read/29384297/-an-illustrated-guide-to-dental-screening-a-school-survey
#12
Annabelle Tenenbaum, Mélanie Sayada, Sylvie Azogui-Levy
AIM: Marked social inequalities in oral health are observed right from early childhood. A mandatory complete health check-up, including dental screening, is organized at school for 6-year-old children. School healthcare professionals are not well trained in dental health. The aim of this study was to assess the relevance of an illustrated guide as a simple and rapid dental screening training tool in order to ensure effective, standardized and reproducible screening. METHODS: A cross-sectional study was conducted in the context of the dental examination performed as part of the health check-up...
December 5, 2017: Santé Publique: Revue Multidisciplinaire Pour la Recherche et L'action
https://www.readbyqxmd.com/read/29380853/oral-health-indicators-for-risk-of-malnutrition-in-elders
#13
L L Wu, K Y Cheung, P Y P Lam, X L Gao
OBJECTIVES: Using both clinical parameters and subjective measures of oral health, this study aimed to identify useful oral health indicators for the risk of malnutrition in elders. DESIGN: Cross-sectional study. SETTING: Five community centers run by non-government organizations (NGOs). PARTICIPANTS: 195 community dwelling elders (65 or above). MEASUREMENTS: An interviewer-administered questionnaire was completed to collect information on elders' socio-demographic background and oral health perception and practice...
2018: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/29363361/influence-of-the-oral-status-on-cardiovascular-diseases-in-an-older-italian-population
#14
Francesca De Angelis, Stefania Basili, Fratto Giovanni, Pompiliu Dan Trifan, Stefano Di Carlo, Licia Manzon
Oral diseases have been adversely associated with cardiovascular diseases (CVD), which are also the most frequent cause of death in older population. The aim of this study was to investigate the association among oral status indexes and CVD in patients aged more than 65 years attending in the Oral department of a public hospital Policlinico Umberto 1 of Rome. The study population consisted of 533 patients. Dental status was detected measuring the Decayed, Missing, and Filled Teeth (DMFT) and Community Periodontal Index (CPI) indexes...
January 2018: International Journal of Immunopathology and Pharmacology
https://www.readbyqxmd.com/read/29357356/genetic-variants-in-pachyonychia-congenita-associated-keratins-increase-susceptibility-to-tooth-decay
#15
Olivier Duverger, Jenna C Carlson, Chelsea M Karacz, Mary E Schwartz, Michael A Cross, Mary L Marazita, John R Shaffer, Maria I Morasso
Pachyonychia congenita (PC) is a cutaneous disorder primarily characterized by nail dystrophy and painful palmoplantar keratoderma. PC is caused by mutations in KRT6A, KRT6B, KRT6C, KRT16, and KRT17, a set of keratin genes expressed in the nail bed, palmoplantar epidermis, oral mucosal epithelium, hair follicle and sweat gland. RNA-seq analysis revealed that all PC-associated keratins (except for Krt6c that does exist in the mouse genome) are expressed in the mouse enamel organ. We further demonstrated that these keratins are produced by ameloblasts and are incorporated into mature human enamel...
January 22, 2018: PLoS Genetics
https://www.readbyqxmd.com/read/29356547/exploring-biological-and-geological-age-related-changes-through-variations-in-intra-and-inter-tooth-proteomes-of-ancient-dentine
#16
Noemi Procopio, Andrew T Chamberlain, Michael Buckley
Proteomic analyses are becoming more widely used in archaeology, particularly for sample characterisation, including species identification, with recent indications of its potential assistance in estimating biological and geological age. However, it remains unclear to what extent different burial environments impact upon aspects of proteome decay. Teeth have to date been much less studied than bone but are ideal to explore decay due to the negligible turnover that occurs in dentine. Here we investigated the proteome variability and deamidation levels of different sections of molar teeth from archaeological bovine mandibles as well as their mandibular bone...
January 22, 2018: Journal of Proteome Research
https://www.readbyqxmd.com/read/29355422/oral-microbiome-studies-potential-diagnostic-and-therapeutic-implications
#17
A Mira
Understanding the microbiology of dental caries is not a mere academic exercise; it provides the basis for preventive, diagnostic, and treatment strategies and gives the dentist a theoretical framework to become a better professional. The last years have seen the development of new research methodologies, ranging from high-throughput sequencing or "omics" techniques to new fluorescence microscopy applications and microfluidics, which have allowed the study of the oral microbiome to an unprecedented level of detail...
February 2018: Advances in Dental Research
https://www.readbyqxmd.com/read/29352083/polyphosphate-accumulating-bacteria-potential-contributors-to-mineral-dissolution-in-the-oral-cavity
#18
Ashley A Breiland, Beverly E Flood, Julia Nikrad, John Bakarich, Matthew Husman, TaekHyun Rhee, Robert S Jones, Jake V Bailey
Bacteria that accumulate polyphosphate have previously been shown to dynamically influence the solubility of phosphatic minerals in marine settings and wastewater. Here we show that dental plaque, saliva, and carious lesions, all contain abundant polyphosphate-accumulating bacteria. Saturation state modeling results, informed by phosphate uptake experiments using the model organism Lactobacillus rhamnosus, which is known to inhabit advanced carious-lesions, suggest that polyphosphate accumulation can lead to undersaturated conditions with respect to hydroxyapatite under some oral cavity conditions...
January 19, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29329566/general-and-erosive-tooth-wear-of-16-year-old-adolescents-in-kuantan-malaysia-prevalence-and-association-with-dental-caries
#19
Noorhazayti Ab Halim, Rashidah Esa, Hooi Pin Chew
BACKGROUND: The objective of this study was to determine the prevalence and severity of general tooth wear (GTW), i.e. tooth wear irrespective of etiology and erosive tooth wear (ETW), i.e. tooth wear predominantly due to erosion; and also to investigate the relationship between ETW and dental caries experience in 16-year-old adolescents in Kuantan, Malaysia. METHODS: A multi-staged cluster sampling method was employed. A total of 598 16-year-old adolescents participated in this study...
January 12, 2018: BMC Oral Health
https://www.readbyqxmd.com/read/29321070/the-effect-of-methamphetamine-abuse-on-dental-caries-and-periodontal-diseases-in-an-eastern-china-city
#20
Tao Ye, Dongliang Sun, Guangying Dong, Guangjie Xu, Ligang Wang, Jinjin Du, Pengcheng Ren, Shibin Yu
BACKGROUND: Dental diseases are among the most frequently reported health problems in drug abusers. However, few studies have been conducted on oral health of methamphetamine (meth) abusers in China. The aim of the present study was to investigate the caries and periodontal health profile of former meth abusers in Eastern China. METHODS: A cross-sectional study was conducted on 162 former meth abusers in the male Zhoushan Compulsory Detoxification Center. A standardized questionnaire, which collected information about age, drug-use duration / pattern, oral hygiene habit and systemic diseases, was administered...
January 10, 2018: BMC Oral Health
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