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https://www.readbyqxmd.com/read/28813618/whole-exome-sequencing-identifies-novel-variants-for-tooth-agenesis
#1
N Dinckan, R Du, L E Petty, Z Coban-Akdemir, S N Jhangiani, I Paine, E H Baugh, A P Erdem, H Kayserili, H Doddapaneni, J Hu, D M Muzny, E Boerwinkle, R A Gibbs, J R Lupski, Z O Uyguner, J E Below, A Letra
Tooth agenesis is a common craniofacial abnormality in humans and represents failure to develop 1 or more permanent teeth. Tooth agenesis is complex, and variations in about a dozen genes have been reported as contributing to the etiology. Here, we combined whole-exome sequencing, array-based genotyping, and linkage analysis to identify putative pathogenic variants in candidate disease genes for tooth agenesis in 10 multiplex Turkish families. Novel homozygous and heterozygous variants in LRP6, DKK1, LAMA3, and COL17A1 genes, as well as known variants in WNT10A, were identified as likely pathogenic in isolated tooth agenesis...
August 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28810984/impact-of-a-7-day-field-training-on-oral-health-condition-in-japan-ground-self-defense-force-personnel
#2
Koji Yamashita, Takeshi Nishiyama, Emi Nagata, Atik Ramadhani, Miki Kawada-Matsuo, Hitoshi Komatsuzawa, Takahiko Oho
INTRODUCTION: In the Japan Ground Self-Defense Force (JGSDF), personnel periodically perform intensive training that mimics the conditions seen in battle and during natural disasters. Military training involves intensive, stressful conditions, and changes in immune responses have been found in personnel following training. Good oral condition is important for military personnel to fulfill their duties; however, they have difficulty performing daily oral care under training conditions...
July 2017: Military Medicine
https://www.readbyqxmd.com/read/28808641/management-of-large-class-ii-lesions-in-molars-how-to-restore-and-when-to-perform-surgical-crown-lengthening
#3
Ana Belén Dablanca-Blanco, Juan Blanco-Carrión, Benjamín Martín-Biedma, Purificación Varela-Patiño, Alba Bello-Castro, Pablo Castelo-Baz
The restoration of endodontic tooth is always a challenge for the clinician, not only due to excessive loss of tooth structure but also invasion of the biological width due to large decayed lesions. In this paper, the 7 most common clinical scenarios in molars with class II lesions ever deeper were examined. This includes both the type of restoration (direct or indirect) and the management of the cavity margin, such as the need for deep margin elevation (DME) or crown lengthening. It is necessary to have the DME when the healthy tooth remnant is in the sulcus or at the epithelium level...
August 2017: Restorative Dentistry & Endodontics
https://www.readbyqxmd.com/read/28776096/influence-of-radiotherapy-on-the-dentin-properties-and-bond-strength
#4
Renata Borges Rodrigues, Carlos José Soares, Paulo Cézar Simamoto Junior, Vitor Carvalho Lara, Victor Elias Arana-Chavez, Veridiana Resende Novais
OBJECTIVES: The objective of this study was to evaluate the biomechanical properties of dentin and the microtensile bond strength (μTBS) performed before or after radiotherapy (RT). MATERIAL AND METHODS: Dentin chemical composition (infrared spectroscopy-FTIR), SEM images, and mechanical properties (Vickers microhardness-VHN and elastic modulus-E) were evaluated comparing no irradiated and irradiate dentin (n = 5). RT was defined by application of 72 Gy (1.8 Gy daily, 5 days per week, during 8 weeks) with sample immersed in distilled water...
August 4, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28759394/impact-of-prolonged-breastfeeding-on-dental-caries-a-population-based-birth-cohort-study
#5
Karen Glazer Peres, Gustavo G Nascimento, Marco Aurelio Peres, Murthy N Mittinty, Flavio Fernando Demarco, Ina Silva Santos, Alicia Matijasevich, Aluisio J D Barros
BACKGROUND: Few studies have assessed the effect of breastfeeding, bottle feeding, and sugar consumption on children's dental caries. We investigated whether the duration of breastfeeding is a risk factor for dental caries in the primary dentition, independently of sugar consumption. METHODS: An oral health study (n = 1303) nested in a birth cohort study was carried out in southern Brazil. The average number of decayed, missing, and filled primary tooth surfaces (dmfs) and severe early childhood caries (S-ECC: dmfs ≥6) were investigated at age 5 years...
July 2017: Pediatrics
https://www.readbyqxmd.com/read/28759120/pit-and-fissure-sealants-for-preventing-dental-decay-in-permanent-teeth
#6
REVIEW
Anneli Ahovuo-Saloranta, Helena Forss, Tanya Walsh, Anne Nordblad, Marjukka Mäkelä, Helen V Worthington
BACKGROUND: Dental sealants were introduced in the 1960s to help prevent dental caries, mainly in the pits and fissures of occlusal tooth surfaces. Sealants act to prevent bacteria growth that can lead to dental decay. Evidence suggests that fissure sealants are effective in preventing caries in children and adolescents compared to no sealants. Effectiveness may, however, be related to caries incidence level of the population. This is an update of a review published in 2004, 2008 and 2013...
July 31, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28749529/effect-and-acceptance-of-silver-diamine-fluoride-treatment-on-dental-caries-in-primary-teeth
#7
Jennifer Clemens, Jaana Gold, Jeffrey Chaffin
OBJECTIVES: Silver diamine fluoride (SDF) treatment has been identified as a potential solution to address the dental public health issues of untreated dental caries and insufficient access to care. The current study assessed the effectiveness of 38 percent SDF in arresting active dental caries lesions and in reducing or preventing associated dental pain and infections in young, at-risk children. METHODS: We enrolled 32 children aged 2-5 years with 118 active caries lesions in primary teeth from a community dental clinic in Oregon...
July 27, 2017: Journal of Public Health Dentistry
https://www.readbyqxmd.com/read/28747831/optimization-of-sugar-replacement-with-date-syrup-in-prebiotic-chocolate-milk-using-response-surface-methodology
#8
Sahar Kazemalilou, Ainaz Alizadeh
Chocolate milk is one of the most commonly used non-fermentative dairy products, which, due to high level of sucrose, could lead to diabetes and tooth decay among children. Therefore, it is important to replace sucrose with other types of sweeteners, especially, natural ones. In this research, response surface methodology (RSM) was used to optimize the ingredients formulation of prebiotic chocolate milk, date syrup as sweetener (4-10%w/w), inulin as prebiotic texturizer (0-0.5%w/w) and carrageenan as thickening agent (0-0...
2017: Korean Journal for Food Science of Animal Resources
https://www.readbyqxmd.com/read/28739318/impact-of-biannual-treatment-with-fluoride-varnish-on-tooth-surface-level-caries-progression-in-children-aged-1-3-years
#9
Maria Anderson, Göran Dahllöf, Fernanda Cunha Soares, Margaret Grindefjord
OBJECTIVE: This study describes caries progression at tooth-surface level in children from 1-3 years of age and the impact of biannual treatment with fluoride varnish. METHODS: Children who participated in a cluster-randomized controlled trial and had shown signs of dental caries were included in this study (n=801). International Caries Detection and Assessment System (ICDAS) was used to classify dental caries. The present study compared children receiving a standard yearly intervention to children receiving the same standard preventive intervention supplemented with an application of fluoride varnish every half year...
July 21, 2017: Journal of Dentistry
https://www.readbyqxmd.com/read/28728812/longitudinal-association-between-obesity-and-dental-caries-in-adolescents
#10
Ling-Wei Li, Hai Ming Wong, Colman P McGrath
OBJECTIVE: To investigate the longitudinal association between obesity and dental caries among adolescents. STUDY DESIGN: The present cohort study was conducted among a random sample of 12-year-old adolescents in Hong Kong. Two rounds of follow-up were performed when the participants were aged 15 and 18 years. A total of 668 participants were included at age 12 years, and 282 of them completed all 3 phases of data collection. Body mass index, waist circumference, waist-to-hip (WHR) ratio, waist-to-height ratio, and triceps skinfold thickness were measured as indices of obesity...
July 17, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28725453/development-of-an-implementation-intention-based-intervention-to-change-children-s-and-parent-carers-behaviour
#11
Karen Davies, Christopher J Armitage, Yin-Ling Lin, James Munro, Tanya Walsh, Peter Callery
BACKGROUND: Implementation intentions enable individuals to translate good intentions into action. Parents and children can find maintaining oral health difficult, as evidenced by the presence of tooth decay. This is a common condition in children in spite of being preventable through the use of regular tooth brushing, fluoride protection and avoiding sugar intake. Even when parents and children are positive about looking after the teeth, they can face challenges in maintaining consistent habits...
2018: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/28721668/quantitative-analysis-of-s-mutans-lactobacillus-and-bifidobacterium-found-in-initial-and-mature-plaques-in-thai-children-with-early-childhood-caries
#12
K Mitrakul, S Chanvitan, A Jeamset, K Vongsawan
AIMS: To quantify Streptococcus mutans, lactobacillus and bifidobacterium in initial and mature plaque collected from children with severe early childhood caries (S-ECC) and caries-free (CF) groups and to analyse the association between these bacteria and caries-related factors in each group. STUDY DESIGN: A collection of 120 initial and overnight supra-gingival plaques were collected from Thai children aged 2-5 years-old (S-ECC = 60, CF = 60). Plaque, gingival indices and decayed, missing, filled tooth (dmft) scores were recorded...
July 18, 2017: European Archives of Paediatric Dentistry: Official Journal of the European Academy of Paediatric Dentistry
https://www.readbyqxmd.com/read/28697775/the-relationship-between-vitamin-d-receptor-gene-polymorphism-and-deciduous-tooth-decay-in-chinese-children
#13
Yuan-Yuan Kong, Jian-Mao Zheng, Wen-Juan Zhang, Qian-Zhou Jiang, Xue-Chao Yang, Miao Yu, Su-Juan Zeng
BACKGROUND: In the present study, we explored the link between vitamin D receptor (VDR) BsmI, TaqI, ApaI and FokI gene polymorphisms with deciduous tooth decay in Chinese children. METHODS: Our study included 380 Chinese children aged 4-7 years, whose DNA sample was collected from the buccal mucosa. VDR gene polymorphisms was determined by PCR-RFLP. RESULTS: The adjusted logistic regression analysis demonstrated that BsmI containing the Bb genotype was linked with the increased risk of deciduous tooth decay (OR = 1...
July 11, 2017: BMC Oral Health
https://www.readbyqxmd.com/read/28685949/traditional-oral-health-beliefs-and-practices-of-bulang-people-in-yunnan-china
#14
Shinan Zhang, Edward C M Lo, Chun-Hung Chu
AIM: The aim of the present study was to explore traditional oral health beliefs among the Bulang ethnic minority group in China. METHODS: Eighteen village leaders, chiefs, elders, and seniors in Yunnan, China were assigned to three focus groups for discussion of traditional oral health beliefs. The discussions were led by a facilitator. Transcripts were made, and data were extracted. RESULTS: The focus group discussions on traditional oral health beliefs addressed three themes: (a) the perception of oral health; (b) the impact of healthy teeth (oral health), in that healthy teeth essentially have an impact on physical health, emotions, and social status; and (c) toothache management, which was regarded as tooth decay (dental caries)...
July 7, 2017: Journal of Investigative and Clinical Dentistry
https://www.readbyqxmd.com/read/28679308/impact-of-systemic-lupus-erythematosus-on-oral-health-related-quality-of-life
#15
J D Corrêa, L G A Branco, D C Calderaro, S M S Mendonça, D V Travassos, G A Ferreira, A L Teixeira, L G Abreu, T A Silva
Oral symptoms in systemic lupus erythematosus (SLE) patients are often unexplored and affect the health-related quality of life. The aims of this study were: (a) to evaluate the oral health condition of SLE patients compared to control subjects without rheumatic diseases; (b) to determine the consequences of oral health condition in the quality of life of these two groups. Individuals with SLE ( n = 75) and without SLE ( n = 78) (control group), paired for gender and age, underwent complete oral examination...
January 1, 2017: Lupus
https://www.readbyqxmd.com/read/28678838/the-oral-bacterial-microbiome-of-occlusal-surfaces-in-children-and-its-association-with-diet-and-caries
#16
Apoena Aguiar Ribeiro, Maria Andrea Azcarate-Peril, Maria Belen Cadenas, Natasha Butz, Bruce J Paster, Tsute Chen, Eric Bair, Roland R Arnold
Dental caries is the most prevalent disease in humans globally. Efforts to control it have been invigorated by an increasing knowledge of the oral microbiome composition. This study aimed to evaluate the bacterial diversity in occlusal biofilms and its relationship with clinical surface diagnosis and dietary habits. Anamneses were recorded from thirteen 12-year-old children. Biofilm samples collected from occlusal surfaces of 46 permanent second molars were analyzed by 16S rRNA amplicon sequencing combined with the BLASTN-based search algorithm for species identification...
2017: PloS One
https://www.readbyqxmd.com/read/28676047/a-longitudinal-study-of-early-childhood-caries-incidence-in-wenzhou-preschool-children
#17
Xiping Wang, Zhiyuan Wei, Qiao Li, Liqin Mei
BACKGROUND: Early childhood caries (ECC) is a serious public health problem in China. Few studies, however, have described the incidence of ECC in China. The purpose of this study was to assess the prevalence and incidence of ECC among preschool children in Wenzhou China. METHODS: Preschool children aged 3-4 years old were surveyed and followed up when they reached 5-6 years of age in the city of Wenzhou in southeast China. The rates of dental caries were determined with prevalence, and incidence density for risk of caries of a person (IDp) and of a tooth surface (IDs)...
July 4, 2017: BMC Oral Health
https://www.readbyqxmd.com/read/28671327/dental-caries-clusters-among-adolescents
#18
John J Warren, John M Van Buren, Steven M Levy, Teresa A Marshall, Joseph E Cavanaugh, Alexandra M Curtis, Justine L Kolker, Karin Weber-Gasparoni
OBJECTIVES: There have been very few longitudinal studies of dental caries in adolescents, and little study of the caries risk factors in this age group. The purpose of this study was to describe different caries trajectories and associated risk factors among members of the Iowa Fluoride Study (IFS) cohort. METHODS: The IFS recruited a birth cohort from 1992 to 1995, and has gathered dietary, fluoride and behavioural data at least twice yearly since recruitment...
July 3, 2017: Community Dentistry and Oral Epidemiology
https://www.readbyqxmd.com/read/28667230/efficacy-evaluation-of-an-anti-caries-varnish-protocol-for-a-phase-ii-randomised-controlled-trial
#19
Peter Milgrom, Ohnmar Tut, Marilynn Rothen, Lloyd Mancl, Marcelle Gallen, Jason M Tanzer
INTRODUCTION: Dental caries (tooth decay) is a common disease in which the products of sugar metabolism by certain bacteria that populate the tooth surface induce the development and progression of lesions (cavities). This is a phase II single-centre randomised, double-blind, active-controlled, parallel-group trial to assess the efficacy of a combination povidone iodine and sodium fluoride dental varnish to determine if it is superior to a varnish containing only sodium fluoride in the prevention of new caries lesions...
June 30, 2017: BMJ Open
https://www.readbyqxmd.com/read/28666841/synthesis-and-characterization-of-zro2-nanoparticles-antimicrobial-activity-and-their-prospective-role-in-dental-care
#20
John Bani Fathima, Arivalagan Pugazhendhi, Rose Venis
Nanomaterials are exerting a pull on deal with biological and pharmaceutical applications. Biomedical grade of zirconia reveals potential mechanical features of oxide ceramics. In this study, antimicrobial activity and anti-tooth decay applications of the synthesized NPs of ZrO2 were determined. The as-prepared ZrO2 NPs were characterized by UV-vis spectroscopy, FTIR and XRD, which determined the formation of ZrO2NPs and their crystalline nature. SEM analysis further revealed spherical shaped NPs and TEM analysis determined the size of the particles in the range of 15-21 nm, respectively...
June 27, 2017: Microbial Pathogenesis
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