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https://www.readbyqxmd.com/read/26848589/the-position-of-his-tag-in-recombinant-ospc-and-application-of-various-adjuvants-affects-the-intensity-and-quality-of-specific-antibody-response-after-immunization-of-experimental-mice
#1
Michal Krupka, Josef Masek, Lucia Barkocziova, Pavlina Turanek Knotigova, Pavel Kulich, Jana Plockova, Robert Lukac, Eliska Bartheldyova, Stepan Koudelka, Radka Chaloupkova, Marek Sebela, Daniel Zyka, Ladislav Droz, Roman Effenberg, Miroslav Ledvina, Andrew D Miller, Jaroslav Turanek, Milan Raska
Lyme disease, Borrelia burgdorferi-caused infection, if not recognized and appropriately treated by antibiotics, may lead to chronic complications, thus stressing the need for protective vaccine development. The immune protection is mediated by phagocytic cells and by Borrelia-specific complement-activating antibodies, associated with the Th1 immune response. Surface antigen OspC is involved in Borrelia spreading through the host body. Previously we reported that recombinant histidine tagged (His-tag) OspC (rOspC) could be attached onto liposome surfaces by metallochelation...
2016: PloS One
https://www.readbyqxmd.com/read/25630814/molecular-adjuvants-based-on-nonpyrogenic-lipophilic-derivatives-of-norabumdp-gmdp-formulated-in-nanoliposomes-stimulation-of-innate-and-adaptive-immunity
#2
Pavlína Turánek Knotigová, Daniel Zyka, Josef Mašek, Anna Kovalová, Michal Křupka, Eliška Bartheldyová, Pavel Kulich, Štěpán Koudelka, Róbert Lukáč, Zuzana Kauerová, Antonín Vacek, Milada Stuchlová Horynová, Alois Kozubík, Andrew D Miller, Ladislav Fekete, Irena Kratochvílová, Jan Ježek, Miroslav Ledvina, Milan Raška, Jaroslav Turánek
PURPOSE: The aim of this work was to demonstrate an immunostimulatory and adjuvant effect of new apyrogenic lipophilic derivatives of norAbuMDP and norAbuGMDP formulated in nanoliposomes. METHODS: Nanoliposomes and metallochelating nanoliposomes were prepared by lipid film hydration and extrusion methods. The structure of the liposomal formulation was studied by electron microscopy, AF microscopy, and dynamic light scattering. Sublethal and lethal γ-irradiation mice models were used to demonstrate stimulation of innate immune system...
April 2015: Pharmaceutical Research
https://www.readbyqxmd.com/read/24929424/transcriptional-control-of-gabaergic-neuronal-subtype-identity-in-the-thalamus
#3
Katherine Sellers, Verena Zyka, Andrew G Lumsden, Alessio Delogu
BACKGROUND: The thalamus is often defined as the 'gateway to consciousness', a feature that is supported by the specific connectivity and electrophysiological properties of its neurons. Inhibitory GABAergic neurons are required for the dynamic gating of information passing through the thalamus. The high degree of heterogeneity among thalamic GABA neurons suggests that, during embryonic development, alternative differentiation programmes exist to guide the acquisition of inhibitory neuron subtype identity...
2014: Neural Development
https://www.readbyqxmd.com/read/24899138/retraction-synthetic-n-acetyl-d-glucosamine-based-fully-branched-tetrasaccharide-a-mimetic-of-the-endogenous-ligand-for-cd69-activates-cd69%C3%A2-%C2%BA-killer-lymphocytes-upon-dimerization-via-a-hydrophilic-flexible-linker-journal-of-medicinal-chemistry-2010-53-4050
#4
Anna Kovalová, Miroslav Ledvina, David Saman, Daniel Zyka, Monika Kubíčková, Lukáš Zídek, Vladimír Sklenář, Petr Pompach, Daniel Kavan, Jan Bílý, Ondřej Vaněk, Zuzana Kubínková, Martina Libigerová, Ljubina Ivanová, Mária Antolíková, Hynek Mrázek, Daniel Rozbeský, Kateřina Hofbauerová, Vladimír Křen, Karel Bezouška
No abstract text is available yet for this article.
June 26, 2014: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/21256901/metallochelating-liposomes-with-associated-lipophilised-norabumdp-as-biocompatible-platform-for-construction-of-vaccines-with-recombinant-his-tagged-antigens-preparation-structural-study-and-immune-response-towards-rhsp90
#5
COMPARATIVE STUDY
Josef Mašek, Eliška Bartheldyová, Pavlína Turánek-Knotigová, Michaela Skrabalová, Zina Korvasová, Jana Plocková, Stěpán Koudelka, Petra Skodová, Pavel Kulich, Michal Křupka, Kateřina Zachová, Lýdie Czerneková, Milada Horynová, Irena Kratochvílová, Andrew D Miller, Daniel Zýka, Jaroslav Michálek, Jana Vrbková, Marek Sebela, Miroslav Ledvina, Milan Raška, Jaroslav Turánek
Hsp90-CA is present in cell wall of Candida pseudohyphae or hyphae-typical pathogenic morphotype for both systemic and mucosal Candida infections. Heat shock protein from Candida albicans (hsp90-CA) is an important target for protective antibodies during disseminated candidiasis of experimental mice and human. His-tagged protein rHsp90 was prepared and used as the antigen for preparation of experimental recombinant liposomal vaccine. Nickel-chelating liposomes (the size around 100nm, PDI≤0.1) were prepared from the mixture of egg phosphatidyl choline and nickel-chelating lipid DOGS-NTA-Ni (molar ratio 95:5%) by hydration of lipid film and extrusion methods...
April 30, 2011: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/20433142/synthetic-n-acetyl-d-glucosamine-based-fully-branched-tetrasaccharide-a-mimetic-of-the-endogenous-ligand-for-cd69-activates-cd69-killer-lymphocytes-upon-dimerization-via-a-hydrophilic-flexible-linker
#6
Anna Kovalová, Miroslav Ledvina, David Saman, Daniel Zyka, Monika Kubícková, Lukás Zídek, Vladimír Sklenár, Petr Pompach, Daniel Kavan, Jan Bílý, Ondrej Vanek, Zuzana Kubínková, Martina Libigerová, Ljubina Ivanová, Mária Antolíková, Hynek Mrázek, Daniel Rozbeský, Katerina Hofbauerová, Vladimír Kren, Karel Bezouska
On the basis of the highly branched ovomucoid-type undecasaccharide that had been shown previously to be an endogenous ligand for CD69 leukocyte receptor, a systematic investigation of smaller oligosaccharide mimetics was performed based on linear and branched N-acetyl-d-hexosamine homooligomers prepared synthetically using hitherto unexplored reaction schemes. The systematic structure-activity studies revealed the tetrasaccharide GlcNAcbeta1-3(GlcNAcbeta1-4)(GlcNAcbeta1-6)GlcNAc (compound 52) and its alpha-benzyl derivative 49 as the best ligand for CD69 with IC(50) as high as 10(-9) M...
May 27, 2010: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/17436342/the-use-of-fmoc-lys-pac-oh-and-penicillin-g-acylase-in-the-preparation-of-novel-semisynthetic-insulin-analogs
#7
Lenka Záková, Daniel Zyka, Jan Jezek, Ivona Hanclová, Miloslav Sanda, Andrzej M Brzozowski, Jirí Jirácek
In this paper, we present the detailed synthetic protocol and characterization of Fmoc-Lys(Pac)-OH, its use for the preparation of octapeptides H-Gly-Phe-Tyr-N-MePhe-Thr-Lys(Pac)-Pro-Thr-OH and H-Gly-Phe-Phe-His-Thr-Pro-Lys(Pac)-Thr-OH by solid-phase synthesis, trypsin-catalyzed condensation of these octapeptides with desoctapeptide(B23-B30)-insulin, and penicillin G acylase catalyzed cleavage of phenylacetyl (Pac) group from Nepsilon-amino group of lysine to give novel insulin analogs [TyrB25, N-MePheB26,LysB28,ProB29]-insulin and [HisB26]-insulin...
May 2007: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/17108253/study-of-physiological-responses-to-acute-carbon-monoxide-exposure-with-a-human-patient-simulator
#8
Whitney A Cesari, Dominique M Caruso, Enela L Zyka, Stuart T Schroff, Charles H Evans, Jon-Philippe K Hyatt
Human patient simulators are widely used to train health professionals and students in a clinical setting, but they also can be used to enhance physiology education in a laboratory setting. Our course incorporates the human patient simulator for experiential learning in which undergraduate university juniors and seniors are instructed to design, conduct, and present (orally and in written form) their project testing physiological adaptation to an extreme environment. This article is a student report on the physiological response to acute carbon monoxide exposure in a simulated healthy adult male and a coal miner and represents how 1) human patient simulators can be used in a nonclinical way for experiential hypothesis testing; 2) students can transition from traditional textbook learning to practical application of their knowledge; and 3) student-initiated group investigation drives critical thought...
December 2006: Advances in Physiology Education
https://www.readbyqxmd.com/read/15427098/-possibilities-of-determination-of-salol-in-combination-with-thymol-and-chloride-of-pilocarpine-in-combination-with-chloride-of-novocaine
#9
R KALVODA, J ZYKA
No abstract text is available yet for this article.
June 15, 1950: Casopis C̆eského Lékárnictva
https://www.readbyqxmd.com/read/14839663/-polarometric-determination-of-the-purity-of-para-aminosalicylic-acid
#10
R KALVODA, J ZYKA
No abstract text is available yet for this article.
December 1950: Casopis C̆eského Lékárnictva
https://www.readbyqxmd.com/read/14839662/-use-of-polarometric-titration-in-the-determination-of-alkaloid-salts
#11
R KALVODA, J ZYKA
No abstract text is available yet for this article.
December 1950: Casopis C̆eského Lékárnictva
https://www.readbyqxmd.com/read/14839649/-determination-of-certain-pharmaceutically-used-acridine-derivatives
#12
A BLAZEK, R KALVODA, J ZYKA
No abstract text is available yet for this article.
December 1950: Casopis C̆eského Lékárnictva
https://www.readbyqxmd.com/read/14792571/-polarometric-determination-of-certain-pharmaceutically-important-substances-with-para-diazobenzenesulphonic-acid
#13
A JINDRA, R KALVODA, J ZYKA
No abstract text is available yet for this article.
1950: Casopis C̆eského Lékárnictva
https://www.readbyqxmd.com/read/14772766/-polarometric-determination-of-hypnotics-somnifera-with-mercury-salts
#14
R KALVODA, J ZYKA
No abstract text is available yet for this article.
1950: Casopis C̆eského Lékárnictva
https://www.readbyqxmd.com/read/14772764/-sympathomimetic-amines
#15
J ZYKA
No abstract text is available yet for this article.
October 15, 1950: Casopis C̆eského Lékárnictva
https://www.readbyqxmd.com/read/14772752/-local-anesthesia
#16
J ZYKA
No abstract text is available yet for this article.
September 15, 1950: Casopis C̆eského Lékárnictva
https://www.readbyqxmd.com/read/14772744/-new-antibiotics-chloromycetin-aureomycin-and-iridomyrmecin
#17
J ZYKA
No abstract text is available yet for this article.
August 15, 1950: Casopis C̆eského Lékárnictva
https://www.readbyqxmd.com/read/14459190/-analytical-studies-on-anticholinergics-from-the-group-of-carboxylic-acid-esters-i-ultraviolet-spectrophotometry-of-2-di-isopropylamino-ethylxanthene-9-carboxylate-methobromide-and-2-di-ethylaminoethyl-xanthene-9-carboxylate-methobromide
#18
https://www.readbyqxmd.com/read/14390580/-polarometric-study-of-the-cadmium-salts-of-citric-and-tartaric-acids
#19
J ZYKA
No abstract text is available yet for this article.
June 1955: Ceskoslovenská Farmacie
https://www.readbyqxmd.com/read/14390579/-polarometric-titration-of-organic-bases-ii-titration-with-phosphotungstic-and-phosphomolybdenic-acids
#20
M SOUCKOVA, J ZYKA
No abstract text is available yet for this article.
June 1955: Ceskoslovenská Farmacie
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