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Menopausal hormonal therapy

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https://www.readbyqxmd.com/read/28938710/hormone-therapy-use-and-risk-of-chronic-disease-in-the-nurses-health-study-a-comparative-analysis-with-the-women-s-health-initiative
#1
Shilpa N Bhupathiraju, Francine Grodstein, Bernard A Rosner, Meir J Stampfer, Frank B Hu, Walter C Willett, JoAnn E Manson
Observational studies and randomized controlled trials of menopausal hormone therapy (HT) and chronic disease risk appear to have divergent results for cardiovascular disease. However, differences may be related to a modifying effect of age, time since menopause, and HT formulation. In the Nurses' Health Study (NHS) (enrolling during 1980-1994 and following participants until 2002), we investigated associations between the use of oral conjugated equine estrogens (CEE) (0.625 mg/day) plus medroxyprogesterone acetate (MPA) (<10 mg/day) or oral CEE alone and cardiovascular disease, cancer, all-cause mortality, and other major endpoints among postmenopausal women, aged 50-79 years at HT initiation...
September 15, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28936482/menopause-and-ischemic-stroke-a-brief-review
#2
Shashank Shekhar, Olivia K Travis, Xiaochen He, Richard J Roman, Fan Fan
Ischemic stroke is one of the leading causes of morbidity and mortality worldwide. Females are protected against stroke before the onset of menopause. Menopause results in increased incidence of stroke when compared to men. The mechanisms of these differences remain to be elucidated. Considering that there is a postmenopausal phenomenon and females in general, are living longer sex hormone-dependent mechanisms have been postulated to be the primary factors responsible for the premenopausal protection from stroke and later to be responsible for the higher incidence and increased the severity of stroke after menopause...
2017: MOJ Toxicol
https://www.readbyqxmd.com/read/28934376/managing-menopausal-symptoms-and-associated-clinical-issues-in-breast-cancer-survivors
#3
Richard J Santen, Cynthia A Stuenkel, Susan R Davis, JoAnn V Pinkerton, Anne Gompel, Mary Ann Lumsden
Objective: Review evidence to guide the management of menopausal signs and symptoms in women after breast cancer and make recommendations accordingly. Evidence: Randomized controlled clinical trials, observational studies, evidence- based guidelines, and expert opinion from professional societies. Background: Several symptoms and clinical problems associated with estrogen depletion -sleep disorders, vulvovaginal atrophy (VVA), vasomotor symptoms (VMS), mood changes, depressive symptoms, cardiovascular disease, osteopenia and osteoporosis- confront the estimated 9...
August 2, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28931356/menopause-a-complex-and-controversial-journey
#4
Salam Chalouhi
Menopause is defined as permanent cessation of menstrual periods, determined retrospectively after a woman has experienced 12 months of amenorrhea without any other obvious cause. Over the years, the discourse surrounding the Climacteric was mainly elicited as a "disease of the castrates", as opposed to the feminist views. There has been a large feminist contribution to both the debate of contraception and menopause in the last few years. Over the years, menopause has been treated in a uniform fashion, as a disease, excluding the different circumstances and lived experiences that patients go through during this sensitive period...
September 2017: Post Reproductive Health
https://www.readbyqxmd.com/read/28930233/dietary-isoflavones-and-breast-cancer-risk
#5
REVIEW
Samira Ziaei, Reginald Halaby
Breast cancer is the deadliest neoplasm in women globally, resulting in a significant health burden. In many cases, breast cancer becomes resistant to chemotherapy, radiation, and hormonal therapies. It is believed that genetics is not the major cause of breast cancer. Other contributing risk factors include age at first childbirth, age at menarche, age at menopause, use of oral contraceptives, race and ethnicity, and diet. Diet has been shown to influence breast cancer incidence, recurrence, and prognosis...
April 7, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/28928661/ginkgo-biloba-extract-gbe-stimulates-the-hypothalamic-serotonergic-system-and-attenuates-obesity-in-ovariectomized-rats
#6
Renata M Banin, Iracema S de Andrade, Suzete M Cerutti, Lila M Oyama, Mônica M Telles, Eliane B Ribeiro
Menopause is associated with increased risk to develop obesity but the mechanisms involved are not fully understood. We have shown that Ginkgo biloba extract (GbE) improved diet-induced obesity. Since GbE might be effective in the treatment of obesity related to menopause, avoiding the side effects of hormone replacement therapy, we investigated the effect of GbE on hypothalamic systems controlling energy homeostasis. Wistar rats were either ovariectomized (OVX) or Sham-operated. After 2 months, either 500 mg...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28926516/association-between-obesity-and-sleep-disorders-in-postmenopausal-women
#7
Maria Fernanda Naufel, Cristina Frange, Monica Levy Andersen, Manoel João Batista Castello Girão, Sergio Tufik, Eliane Beraldi Ribeiro, Helena Hachul
OBJECTIVE: To investigate the relationship between obesity and sleep architecture in postmenopausal women. METHODS: One hundred seven postmenopausal women from the Ambulatory of Integrative Treatment for Female Sleep Disorders were invited by telephone to participate in this study. Fifty-three completed the study. We included women aged 50 to 70 years, and excluded women on hormone therapy or missing data. The study consisted of two meetings, including a full-night polysomnography...
September 18, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28923411/hormone-replacement-therapy-after-treatment-for-cervical-cancer-are-we-adhering-to-standard-of-care
#8
Lisa A Rauh, Aaron F Pannone, Leigh A Cantrell
OBJECTIVE: The aim of this study was to assess hormone replacement therapy (HRT) and bone care health maintenance practices for cervical cancer patients with iatrogenic menopause, and, secondarily, to investigate the potential impact of specific demographic and clinical factors. METHODS: Women diagnosed with iatrogenic menopause due to cervical cancer treatment between January 1, 2005 and December 31, 2015 were identified from the University of Virginia's tumor registry...
September 16, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28923180/menopause-in-latin-america-symptoms-attitudes-treatments-and-future-directions-in-costa-rica
#9
REVIEW
T D Locklear, B J Doyle, A L Perez, S M Wicks, G B Mahady
Similar to their US counterparts, Costa Rican women enter menopause at ∼50 years of age, have similar symptoms, including hot flashes and night sweats, as well as an overall negative attitude toward the menopausal transition. One study of rural women in Monteverde reported that women knew little about the menopausal transition, as the subject was not discussed. Similar to other Latin American women, the use of hormone therapy by Costa Rican women is low and instead they use alternative therapies, including massage, dietary changes and herbal medicines...
October 2017: Maturitas
https://www.readbyqxmd.com/read/28919172/comments-on-the-uspstf-draft-recommendation-statement-on-menopausal-hormone-therapy-primary-prevention-of-chronic-conditions
#10
EDITORIAL
Antonio Cano, Margaret Rees, Tommaso Simoncini
No abstract text is available yet for this article.
September 8, 2017: Maturitas
https://www.readbyqxmd.com/read/28917368/improving-vasomotor-symptoms-psychological-symptoms-and-health-related-quality-of-life-in-peri-or-post-menopausal-women-through-yoga-an-umbrella-systematic-review-and-meta-analysis
#11
REVIEW
M Shepherd-Banigan, K M Goldstein, R R Coeytaux, J R McDuffie, A P Goode, A S Kosinski, M G Van Noord, D Befus, S Adam, V Masilamani, A Nagi, J W Williams
OBJECTIVES: Vasomotor symptoms (VMS), commonly reported during menopausal transition, negatively affect psychological health and health-related quality of life (HRQoL). While hormone therapy is an effective treatment, its use is limited by concerns about possible harms. Thus, many women with VMS seek nonhormonal, nonpharmacologic treatment options. However, evidence to guide clinical recommendations is inconclusive. This study reviewed the effectiveness of yoga, tai chi and qigong on vasomotor, psychological symptoms, and HRQoL in peri- or post-menopausal women...
October 2017: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/28914701/elevated-postvoid-residual-urine-volume-identifying-risk-factors-and-predicting-resolution-in-women-with-pelvic-organ-prolapse
#12
Amanda Ulrich, Patricia Davis, Paul Tulikangas, David M OʼSullivan, Katie Propst
OBJECTIVES: This study aims to identify risk factors for elevated preoperative postvoid residual (PVR) and persistently elevated postoperative PVR and to evaluate the resolution rate of elevated PVR urine volume in patients undergoing reconstructive surgery for pelvic organ prolapse (POP). METHODS: This was a retrospective cohort study comparing 50 women with elevated preoperative PVR (≥100 mL) and 50 women with normal PVR (<100 mL). Preoperative demographic, physical examination, urodynamic data, type of surgery performed, and postoperative trial of void data were collected...
September 13, 2017: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/28914436/chinese-and-indian-women-s-experience-with-alternative-medications-for-menopause-related-symptoms-a-qualitative-analysis
#13
Saw Ohn Mar, Fatehpal Singh Malhi, Syed Hamid Syed Rahim, Myint Myint Soe
OBJECTIVE: To explore women's rationalization for using alternative medications, their experience and view on safety of long-term use. METHODS: Two focus group discussions, involving 5 participants each for Chinese and Indian groups, were conducted separately. Participant's personal information was collected anonymously. The discussion covered 5 areas: determinants for taking medications; reason for choosing alternative medications rather than hormone replacement therapy (HRT); how these medications help them; their view on cost-effectiveness and concerns over long-term use...
September 15, 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28913650/does-levonorgestrel-releasing-intrauterine-system-increase-breast-cancer-risk-in-peri-menopausal-women-an-hmo-perspective
#14
Nava Siegelmann-Danieli, Itzhak Katzir, Janet Vesterman Landes, Yaakov Segal, Rachel Bachar, Hadas Rotem Rabinovich, Martin Bialik, Joseph Azuri, Avi Porath, Yossef Lomnicky
PURPOSE: To evaluate the association between levonorgestrel-releasing intrauterine system (LNG-IUS) use and breast cancer (BC) risk. METHODS: A cohort of all Maccabi Healthcare Services (MHS) female members aged 40-50 years between 1/2003 and 12/2013 was used to identify LNG-IUS users as "cases," and 2 age-matched non-users as "controls." Exclusion criteria included: prior BC diagnosis, prior (5 years pre-study) and subsequent treatment with other female hormones or prophylactic tamoxifen...
September 14, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28904736/beer-polyphenols-and-menopause-effects-and-mechanisms-a-review-of-current-knowledge
#15
REVIEW
Berner Andrée Sandoval-Ramírez, Rosa M Lamuela-Raventós, Ramon Estruch, Gemma Sasot, Monica Doménech, Anna Tresserra-Rimbau
Beer is one of the most frequently consumed fermented beverages in the world, and it has been part of the human diet for thousands of years. Scientific evidence obtained from the development of new techniques of food analysis over the last two decades suggests that polyphenol intake derived from moderate beer consumption may play a positive role in different health outcomes including osteoporosis and cardiovascular risk and the relief of vasomotor symptoms, which are commonly experienced during menopause and are an important reason why women seek medical care during this period; here, we review the current knowledge regarding moderate beer consumption and its possible effects on menopausal symptoms...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28903616/circulating-dehydroepiandrosterone-sulphate-decreases-even-with-a-slight-change-in-oestradiol
#16
Sumika Matsui, Toshiyuki Yasui, Kana Kasai, Kanako Yoshida, Takeshi Kato, Hirokazu Uemura, Akira Kuwahara, Toshiya Matsuzaki, Minoru Irahara
The aim of this study was to determine the effect of hormone replacement therapy (HRT) on changes in circulating dehydroepiandrosterone-sulphate (DHEA-S) with focus on the relationship between oestrogen level and change in DHEA-S. Forty-two women were enrolled in this longitudinal study. Nineteen women received oral oestradiol and twenty-three women received transdermal oestradiol continuously. Twenty women received progesterone continuously except for women who had undergone hysterectomy. Circulating oestradiol, follicle-stimulating hormone, luteinising hormone and DHEA-S levels before and at 3 months after commencement of HRT were measured...
September 14, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28900379/postmenopausal-hormone-and-the-risk-of-nephrolithiasis-a-meta-analysis
#17
Juan Yu, Binyan Yin
Menopause is reported to be associated with increased urinary calcium excretion, which may enhance the risk for the development of calcium kidney stones. However, it remains controversial about whether high level of postmenopausal hormone (PMH) is a risk factor for formation of nephrolithiasis. Several observational studies have shown that PMH is protective based on 24-hour urinary parameters. Recent clinical trials provided evidence to conclude that estrogen therapy increases the risk of nephrolithiasis in healthy postmenopausal women...
2017: EXCLI journal
https://www.readbyqxmd.com/read/28898378/menopausal-hormone-therapy-and-long-term-all-cause-and-cause-specific-mortality-the-women-s-health-initiative-randomized-trials
#18
RANDOMIZED CONTROLLED TRIAL
JoAnn E Manson, Aaron K Aragaki, Jacques E Rossouw, Garnet L Anderson, Ross L Prentice, Andrea Z LaCroix, Rowan T Chlebowski, Barbara V Howard, Cynthia A Thomson, Karen L Margolis, Cora E Lewis, Marcia L Stefanick, Rebecca D Jackson, Karen C Johnson, Lisa W Martin, Sally A Shumaker, Mark A Espeland, Jean Wactawski-Wende
Importance: Health outcomes from the Women's Health Initiative Estrogen Plus Progestin and Estrogen-Alone Trials have been reported, but previous publications have generally not focused on all-cause and cause-specific mortality. Objective: To examine total and cause-specific cumulative mortality, including during the intervention and extended postintervention follow-up, of the 2 Women's Health Initiative hormone therapy trials. Design, Setting, and Participants: Observational follow-up of US multiethnic postmenopausal women aged 50 to 79 years enrolled in 2 randomized clinical trials between 1993 and 1998 and followed up through December 31, 2014...
September 12, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28898364/menopausal-hormone-therapy-understanding-long-term-risks-and-benefits
#19
Melissa McNeil
No abstract text is available yet for this article.
September 12, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28894854/the-relationship-between-breast-cancer-and-risk-factors-a-single-center-study
#20
Arzu Ozsoy, Nurdan Barca, Betul Akdal Dolek, Hafize Aktaş, Eda Elverici, Levent Araz, Ozlen Ozkaraoğlu
OBJECTIVE: To determine the relationship between breast cancer and known risk factors in patients who had mammography (MG) for breast cancer screening or ultrasonography and/or MG for diagnostic purposes. MATERIALS AND METHODS: In the period of January-December, 2011, a questionnaire composed of 17 questions was applied to 2862 female patients and MG and/or US examination was performed afterwards. Chi-square and Kruskal-Wallis tests were used for statistical analysis...
July 2017: Eur J Breast Health
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