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Menopausal hormonal therapy

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https://www.readbyqxmd.com/read/28106545/the-alterations-of-serum-fgf-21-levels-metabolic-and-body-composition-in-early-breast-cancer-patients-receiving-adjuvant-endocrine-therapy
#1
Murat Akyol, Ahmet Alacacioglu, Leyla Demir, Yuksel Kucukzeybek, Yasar Yildiz, Zehra Gumus, Mete Kara, Tarik Salman, Umut Varol, Halil Taskaynatan, Utku Oflazoglu, Vedat Bayoglu, Mustafa Oktay Tarhan
BACKGROUND: In early breast cancer patients, the effects of hormonal therapy (tamoxifen and aromatase inhibitors) on plasma fibroblast growth factor 21 (FGF-21), lipid levels and body composition have not yet been investigated. Therefore, we aimed to analyze the relationship between FGF-21 and body composition as well as the effects of tamoxifen and aromatase inhibitors on plasma lipid levels, FGF-21, and body composition. METHODS: A total of 72 patients were treated with either tamoxifen or aromatase inhibitors due to their menopausal status after adjuvant radiotherapy...
January 13, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/28093732/long-term-hormone-therapy-for-perimenopausal-and-postmenopausal-women
#2
REVIEW
Jane Marjoribanks, Cindy Farquhar, Helen Roberts, Anne Lethaby, Jasmine Lee
BACKGROUND: Hormone therapy (HT) is widely provided for control of menopausal symptoms and has been used for the management and prevention of cardiovascular disease, osteoporosis and dementia in older women. This is an updated version of a Cochrane review first published in 2005. OBJECTIVES: To assess effects of long-term HT (at least 1 year's duration) on mortality, cardiovascular outcomes, cancer, gallbladder disease, fracture and cognition in perimenopausal and postmenopausal women during and after cessation of treatment...
January 17, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28091974/clinical-trial-shows-lasting-function-of-a%C3%A2-new-moisturizing-cream-against-vaginal-dryness
#3
Hans-Heinrich Henneicke-von Zepelin, Ragna Williams, Wiebke Havemeister, Walter Wigger-Alberti, Klaus-Ulrich Nolte
Vaginal dryness and associated symptoms may occur in women of any age and are a frequent burden after menopause. The North American Menopause Society recommends long-acting non-hormonal vaginal creams as first-line therapy. A new type of such creams was developed (Remifemin® FeuchtCreme in Austria and Germany). This hormone-free cream contains hamamelis virginiana distillate and well-established vaginal cream ingredients. We explored its physical function and tolerability in an open interventional clinical trial...
January 13, 2017: Wiener Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28076614/association-between-asthma-and-female-sex-hormones
#4
Raquel Prudente de Carvalho Baldaçara, Ivaldo Silva
CONTEXT AND OBJECTIVE: The relationship between sex hormones and asthma has been evaluated in several studies. The aim of this review article was to investigate the association between asthma and female sex hormones, under different conditions (premenstrual asthma, use of oral contraceptives, menopause, hormone replacement therapy and pregnancy). DESIGN AND SETTING: Narrative review of the medical literature, Universidade Federal do Tocantins (UFT) and Universidade Federal de São Paulo (Unifesp)...
January 5, 2017: São Paulo Medical Journal, Revista Paulista de Medicina
https://www.readbyqxmd.com/read/28074678/prevention-of-alzheimer-s-disease-cerebrovascular-disease-and-dementia-in-women-the-case-for-menopause-hormone-therapy
#5
Dennis A Davey
Alzheimer's disease, cerebrovascular disease and aging-related cognitive impairment and dementia (ARCID) increase in prevalence in women with advancing age. The development of Alzheimer's disease, cerebrovascular disease and ARCID may be postponed or prevented by protective measures including the active treatment of vascular risk factors and continuing exercise and healthy lifestyle from early- and mid-life onward. Bilateral oophorectomy before the natural menopause is associated with an increased incidence of ARCID and the increased risk is significantly reduced by estrogen therapy...
January 11, 2017: Neurodegenerative Disease Management
https://www.readbyqxmd.com/read/28069684/weight-fluctuation-and-cancer-risk-in-post-menopausal-women-the-women-s-health-initiative
#6
Laura M Welti, Daniel P Beavers, Bette J Caan, Haleh Sangi-Haghpekar, Mara Z Vitolins, Kristen M Beavers
BACKGROUND: Weight cycling, defined by an intentional weight loss and subsequent regain, commonly occurs in overweight and obese women and is associated with some negative health outcomes. We examined the role of various weight-change patterns during early to mid- adulthood and associated risk of highly prevalent, obesity-related cancers (breast, endometrial, colorectal) in postmenopausal women. METHODS: 80,943 postmenopausal women (age: 63.4±7.4 years) in the Women's Health Initiative Observational Study were categorized by self-reported weight change (weight stable; weight gain; lost weight; weight cycled [1-3, 4-6, 7-10, >10 times]) during early to mid- adulthood (18-50 years)...
January 9, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28064520/menopause-hormone-therapy-and-diabetes
#7
C A Stuenkel
Over the past three decades, the prevalence of diabetes has increased four-fold. Coupled with the global obesity epidemic and aging of the world's population, a perfect metabolic storm is brewing. The influence of menopause and exogenous estrogen and progestogens must be included in this equation. In this review, criteria for diagnosing diabetes and recommendations for screening are described. The reported effects of menopause on diabetes risk in healthy women are reviewed as well as the relationship between established diabetes and the timing of menopause...
January 8, 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28057121/-consensus-of-hormone-replacement-therapy-for-premature-ovarian-insufficiency
#8
(no author information available yet)
No abstract text is available yet for this article.
December 25, 2016: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/28054115/-risk-and-benefit-of-nutritional-supplements-for-the-treatment-of-postmenopausal-complaints
#9
Patrick Diel, Anne Kurrat, Christina Oden, Lars Hanke
Menopause is for many females associated with an occurrence of a variety of health complaints and a decrease in quality in life. Hot flashes, sleep disturbances and a variety of other symptoms result in a strong psychological strain. Hormone replacement therapy for treatment of climacteric complaints is discussed controversially regarding associated side effects. This is a major reason to propose treatment with plant derived extracts and compounds as an alternative. Such compounds are available either as drugs but mostly as nutritional supplements...
January 4, 2017: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/28051040/pulsatile-gonadotropin-releasing-hormone-therapy-is-associated-with-earlier-spermatogenesis-compared-to-combined-gonadotropin-therapy-in-patients-with-congenital-hypogonadotropic-hypogonadism
#10
Jiang-Feng Mao, Zhao-Xiang Liu, Min Nie, Xi Wang, Hong-Li Xu, Bing-Kun Huang, Jun-Jie Zheng, Le Min, Ursula Brigitte Kaiser, Xue-Yan Wu
Both pulsatile gonadotropin-releasing hormone (GnRH) infusion and combined gonadotropin therapy (human chorionic gonadotropin and human menopausal gonadotropin [HCG/HMG]) are effective to induce spermatogenesis in male patients with congenital hypogonadotropic hypogonadism (CHH). However, evidence is lacking as to which treatment strategy is better. This retrospective cohort study included 202 patients with CHH: twenty had received pulsatile GnRH and 182 had received HCG/HMG. Patients had received therapy for at least 12 months...
December 27, 2016: Asian Journal of Andrology
https://www.readbyqxmd.com/read/28042728/a-brief-history-of-the-international-menopause-society
#11
R J Baber, J Wright
Although some understanding of post-reproductive life dates back to Ancient Greece, the term 'menopause' was only introduced in the early 1800s by a French physician. Notwithstanding familiarity with the condition at that time, treatments were largely ineffective, often harmful and never evidence-based, and it was not until 100 years later with the identification and description of estrogen and progesterone that effective treatments became available. So efficacious were hormone therapies for menopausal symptoms that their prescription was often recommended for all postmenopausal women regardless of their needs, wishes or health status...
January 2, 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28041951/the-role-of-sex-hormones-and-steroid-receptors-on-female-reproductive-cancers
#12
REVIEW
Luiz Gustavo de Almeida Chuffa, Luiz Antonio Lupi-Júnior, Aline Balandis Costa, João Paulo de Arruda Amorim, Fábio Rodrigues Ferreira Seiva
Sex steroids have been widely described to be associated with a number of human diseases, including hormone-dependent tumors. Several studies have been concerned about the factors regulating the availability of sex steroids and its importance in the pathophysiological aspects of the reproductive cancers in women. In premenopausal women, large fluctuations in the concentration of circulating estradiol (E2) and progesterone (P4) orchestrate many events across the menstrual cycle. After menopause, the levels of circulating E2 and P4 decline but remain at high concentration in the peripheral tissues...
February 2017: Steroids
https://www.readbyqxmd.com/read/28034360/role-of-nanoparticles-in-drug-delivery-and-regenerative-therapy-for-bone-diseases
#13
Sonia Gera, Sunitha Sampathi, Sujatha Dodoala
Osteoporosis (OP) is a disease characterized by progressive bone loss due to aging and menopause in women leading to bone fragility with increased susceptibility towards fractures. The silent disease weakens the bone by altering its microstructure and mass. Therapy is based on either promoting strength (via osteoblast action) or preventing disease (via osteoclast action). Current therapy with different drugs belonging to antiresorptive, anabolic and hormonal classification suffers from poor pharmacokinetic and pharmacodynamic profile...
December 30, 2016: Current Drug Delivery
https://www.readbyqxmd.com/read/28032426/lipoprotein-a-in-postmenopausal-women-assessment-of-cardiovascular-risk-and-therapeutic-options
#14
REVIEW
Panagiotis Anagnostis, Spyridon Karras, Irene Lambrinoudaki, John C Stevenson, Dimitrios G Goulis
INTRODUCTION: Lipoprotein(a) [Lp(a)], a low-density lipoprotein (LDL)-like particle, has been independently associated with increased cardiovascular disease (CVD) risk in various populations, such as postmenopausal women. The purpose of this narrative review is to present current data on the role of Lp(a) in augmenting CVD risk in postmenopausal women and focus on the available therapeutic strategies. METHODS: PubMed was searched for English language publications until November 2015 under the following terms: "therapy" OR "treatment" AND ["lipoprotein (a)" OR "Lp(a)"] AND ("postmenopausal women" OR "menopausal women" OR "menopause")...
December 2016: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28029304/cognitive-complaints-in-survivors-of-breast-cancer-after-chemotherapy-compared-with-age-matched-controls-an-analysis-from-a-nationwide-multicenter-prospective-longitudinal-study
#15
Michelle C Janelsins, Charles E Heckler, Luke J Peppone, Charles Kamen, Karen M Mustian, Supriya G Mohile, Allison Magnuson, Ian R Kleckner, Joseph J Guido, Kelley L Young, Alison K Conlin, Lora R Weiselberg, Jerry W Mitchell, Christine A Ambrosone, Tim A Ahles, Gary R Morrow
Purpose Cancer-related cognitive impairment is an important problem for patients with breast cancer, yet its trajectory is not fully understood. Some previous cancer-related cognitive impairment research is limited by heterogeneous populations, small samples, lack of prechemotherapy and longitudinal assessments, use of normative data, and lack of generalizability. We addressed these limitations in a large prospective, longitudinal, nationwide study. Patients and Methods Patients with breast cancer from community oncology clinics and age-matched noncancer controls completed the Functional Assessment of Cancer Therapy-Cognitive Function (FACT-Cog) at prechemotherapy and postchemotherapy and at a 6-month follow-up as an a priori exploratory aim...
December 28, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28008302/benefits-of-hormone-therapy-estrogens-depend-on-estrogen-type-17%C3%AE-estradiol-and-conjugated-equine-estrogens-have-differential-effects-on-cognitive-anxiety-like-and-depressive-like-behaviors-and-increase-tryptophan-hydroxylase-2-mrna-levels-in-dorsal-raphe-nucleus
#16
Ryoko Hiroi, Giulia Weyrich, Stephanie V Koebele, Sarah E Mennenga, Joshua S Talboom, Lauren T Hewitt, Courtney N Lavery, Perla Mendoza, Ambra Jordan, Heather A Bimonte-Nelson
Decreased serotonin (5-HT) function is associated with numerous cognitive and affective disorders. Women are more vulnerable to these disorders and have a lower rate of 5-HT synthesis than men. Serotonergic neurons in the dorsal raphe nucleus (DRN) are a major source of 5-HT in the forebrain and play a critical role in regulation of stress-related disorders. In particular, polymorphisms of tryptophan hydroxylase-2 (TpH2, the brain-specific, rate-limiting enzyme for 5-HT biosynthesis) are implicated in cognitive and affective disorders...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28006838/menopausal-hormone-therapy-and-the-risk-of-esophageal-and-gastric-cancer
#17
Nele Brusselaers, John Maret-Ouda, Peter Konings, Hashem B El-Serag, Jesper Lagergren
A protective effect of female sex hormones has been suggested to explain the male predominance in esophageal and gastric adenocarcinoma, but evidence is lacking. We aimed to test whether menopausal hormone therapy (MHT) decreases the risk of these tumors. For comparison, esophageal squamous cell carcinoma was also assessed. This population-based matched cohort study included all women who had ever used systemic MHT in Sweden in 2005-2012. A comparison cohort of non-users of MHT was matched to the MHT-users regarding age, parity, thrombotic events, hysterectomy, diabetes, obesity, smoking-related diseases and alcohol-related diseases...
December 22, 2016: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27997360/salvia-miltiorrhiza-bunge-decreases-estrogen-level-without-side-effects-on-reproductive-tissues-in-immature-ovariectomized-mice
#18
Ying Xu, Ting Chen, Xin Li, Ya-Kun Qu, Jin-Na An, Hong-Xia Zheng, Zi-Jia Zhang, Na Lin
Salvia miltiorrhiza bunge(SM) is a popular herb for alleviating menopausal symptoms, although the scientific evidence of applying SM to estrogen replacement therapy is limited. In this study, we characterized the estrogenic activity of SM using in vivo models of immature and ovariectomized (OVX) mice and performed in vitro studies focusing on the estrogen receptor (ER) pathway for further molecular characterizations. SM treatments demonstrated significant estrogenic activity by promoting the development of uterus and vagina in immature mice, restoring the estrus cycle and reversing the atrophy of reproductive tissues in OVX mice, as well as increasing the expressions of ERα and ERβ at protein and mRNA level in the reproductive tissues...
December 20, 2016: Aging
https://www.readbyqxmd.com/read/27991998/migraine-in-the-post-menopausal-period-is-associated-with-higher-levels-of-mood-disorders-disability-and-more-menopausal-symptoms
#19
Paula Carturan, Claudio Scorcine, Yara Dadalti Fragoso
Objective: To assess the prevalence of headache in post-menopausal women. Methods: Women attending gynecology outpatient services in the coastal region of the state of Sao Paulo, Brazil were invited to participate in this study. Only those with non-surgical menopause and no hormone replacement therapy were included. Prevalence and characterization of headaches were assessed, as well as the burden of migraine, traits of anxiety and depression, and menopausal symptomatology...
December 2016: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/27981878/xenogeneic-decellularized-scaffold-a-novel-platform-for-ovary-regeneration
#20
Wen-Yue Liu, Shi-Gang Lin, Ru-Yi Zhuo, Yuan-Yuan Xie, Wei Pan, Xian-Feng Lin, Fei-Xia Shen
Women younger than 40 years may face early menopause because of premature ovarian failure (POF). The cause of POF can be idiopathic or iatrogenic, especially the cancer-induced oophorectomy and chemo- or radiation therapy. The current treatments, including hormone replacement therapy (HRT) and cryopreservation techniques, have increased risk of ovarian cancer and may reintroduce malignant cells after autografting. Decellularization technique has been regarded as a novel regenerative medicine strategy for organ replacement, wherein the living cells of an organ are removed, leaving the extracellular matrix (ECM) for cellular seeding...
January 10, 2017: Tissue Engineering. Part C, Methods
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