Thiago S Oliveira, Hericles M Campos, Rafael M Costa, Raphaela C Georg, Jacqueline A Leite, Rita C Tostes, Elson A Costa, Fernanda Cristina A Santos, Núbia S Lobato, Fernando P Filgueira, Paulo César Ghedini
Estrone (E1) constitutes the primary component in oral conjugated equine estrogens (CEEs) and serves as the principal estrogen precursor in the female circulation in the post-menopause. E1 induces endothelium-dependent vasodilation and activate PI3K/NO/cGMP signaling. To assess whether E1 mitigates vascular dysfunction associated with postmenopause and explore the underlying mechanisms, we examined the vascular effects of E1 in ovariectomized (OVX) rats, a postmenopausal experimental model. Blood pressure was measured using tail-cuff plethysmography, and aortic rings were isolated to assess responses to phenylephrine, acetylcholine (ACh), and sodium nitroprusside...
April 21, 2024: Naunyn-Schmiedeberg's Archives of Pharmacology