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Menopausal hormonal therapy

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https://www.readbyqxmd.com/read/28324062/gene-hormone-therapy-interaction-and-fracture-risk-in-postmenopausal-women
#1
Youjin Wang, Jean Wactawski-Wende, Lara E Sucheston-Campbell, Leah Preus, Kathleen M Hovey, Jing Nie, Rebecca D Jackson, Samuel K Handelman, Rami Nassir, Carolyn J Crandall, Heather M Ochs-Balcom
Context: Evidence supports a protective effect of menopausal hormone therapy (HT) on bone. However, whether genetic susceptibility modifies the association of HT and fracture risk is not sufficiently explored. Objective: The objective was to test an interaction between genetic susceptibility and HT on fracture risk. Design: We constructed two weighted genetic risk scores (GRSs) based on 16 fracture-associated variants (Fx-GRS) and 50 bone mineral density (BMD) variants (BMD-GRS)...
March 6, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28323934/menopausal-hormone-therapy-and-type-2-diabetes-prevention-evidence-mechanisms-and-clinical-implications
#2
Franck Mauvais-Jarvis, JoAnn E Manson, John C Stevenson, Vivian A Fonseca
Type 2 diabetes has reached epidemic proportions in the US. Large randomized controlled trials suggest that menopausal hormone therapy (MHT) delays the onset of type 2 diabetes in women. Still, the mechanisms and clinical implications of these associations are a matter of controversy. This review provides an up-to-date analysis and integration of epidemiological, clinical and basic studies, and proposes a mechanistic explanation for the effect of menopause and MHT on type 2 diabetes development and prevention...
March 8, 2017: Endocrine Reviews
https://www.readbyqxmd.com/read/28323912/sex-hormones-and-cardiometabolic-health-role-of-estrogen-and-estrogen-receptors
#3
Deborah Clegg, Andrea L Hevener, Kerrie L Moreau, Eugenia Morselli, Alfredo Criollo, Rachael E Van Pelt, Victoria J Vieira-Potter
With increased life expectancy, women will spend over three decades of life post-menopause. The menopausal transition increases susceptibility to metabolic diseases such as obesity, diabetes, cardiovascular disease, and cancer. Thus, it is more important than ever to develop effective hormonal treatment strategies to protect aging women. Understanding the role of estrogens, and their biological actions mediated by estrogen receptors (ERs), in the regulation of cardiometabolic health is of paramount importance to discover novel targeted therapeutics...
February 17, 2017: Endocrinology
https://www.readbyqxmd.com/read/28323768/use-of-cardiovascular-age-for-assessing-risks-and-benefits-of-menopausal-hormone-therapy
#4
Richard J Santen
The Women's Health Initiative studies and others have suggested that menopausal hormone therapy may enhance the risk of new cardiovascular (CV) events in older women and diminish the development of coronary atherosclerosis in younger women. The underlying mechanisms to explain these findings are encapsulated in the term "Timing Hypothesis." Extensive pathophysiologic studies have provided mechanistic evidence for the dichotomous effects of estrogen on coronary artery vasculature. Early in the atherosclerotic disease process, estrogen exerts protective effects on the endothelium and retards plaque formation...
March 20, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28323628/effects-of-bach-flower-remedies-on-menopausal-symptoms-and-sleep-pattern-a-case-report
#5
Marcele Siegler, Cristina Frange, Monica Levy Andersen, Sergio Tufik, Helena Hachul
Context • During the postmenopausal stage, women go through many remarkable changes, including physical, emotional, and hormonal. They also experience some unwanted effects, such as vasomotor symptoms, anxiety, and insomnia. The use of Bach flower remedies has been described as a supporting therapy for those symptoms. Objectives • The investigation aimed to evaluate the effects of the supplement on sleep pattern (ie, sleep perception and objective sleep) and on menopausal symptoms. Design • The research team created a case report...
March 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/28323624/conventional-or-natural-pharmacotherapy-and-the-prevalence-of-anxiety-and-depression-during-menopause
#6
Dorota Kopciuch, Anna Paczkowska, Tomasz Zaprutko, Michał Michalak, Elżbieta Nowakowska
Context • Psychoneurological symptoms are present in nearly all women in the perimenopausal period. Key elements of care in the period may include hormone replacement therapy (HRT). Alternatively, phytoestrogens, antidepressant pharmacotherapy, or a combination of hormonal and antidepressant therapies may be recommended. Objective • The study intended to verify whether women who are menopausal believe that a reduction in their symptoms of anxiety and depression depends on the type of pharmacotherapy used...
March 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/28302915/sex-differences-in-ischaemic-stroke-potential-cellular-mechanisms
#7
REVIEW
Anjali Chauhan, Hope Moser, Louise D McCullough
Stroke remains a leading cause of mortality and disability worldwide. More women than men have strokes each year, in part because women live longer. Women have poorer functional outcomes, are more likely to need nursing home care and have higher rates of recurrent stroke compared with men. Despite continued advancements in primary prevention, innovative acute therapies and ongoing developments in neurorehabilitation, stroke incidence and mortality continue to increase due to the aging of the U.S. POPULATION: Sex chromosomes (XX compared with XY), sex hormones (oestrogen and androgen), epigenetic regulation and environmental factors all contribute to sex differences...
April 1, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28301216/bioidentical-menopausal-hormone-therapy-registered-hormones-non-oral-estradiol%C3%A2-%C3%A2-%C3%A2-progesterone-are-optimal
#8
M L'Hermite
The many advantages of registered bioidentical sex hormones over registered, conventional, non-bioidentical menopausal hormone therapy (MHT) are considered. The transdermal route of estrogen administration avoids excess venous thromboembolic and ischemic stroke events. There is some indication that conjugated equine estrogens are more thrombogenic and most likely induce some hypertensive responses; estradiol might also be superior to conjugated equine estrogens (CEE) in terms of global cardiovascular health...
March 16, 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28291028/tailoring-strategies-for-the-management-of-depression-in-midlife-years
#9
Claudio N Soares
Depression affects one in every five adults in North America. Women are more affected than men, possibly because of genetics, coping strategies, and hormone variations. The concept of a menopause-associated depression, however, remains a complex and controversial topic. Although hormone therapy is not recommended as first-line therapy for depression in midlife women, estrogen-based hormone therapy may minimize the need for or enhance the response to antidepressant or behavior-based therapies in select perimenopausal women...
March 13, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28288659/a-clinical-model-for-identifying-the-short-term-risk-of-breast-cancer
#10
Mikael Eriksson, Kamila Czene, Yudi Pawitan, Karin Leifland, Hatef Darabi, Per Hall
BACKGROUND: Most mammography screening programs are not individualized. To efficiently screen for breast cancer, the individual risk of the disease should be determined. We describe a model that could be used at most mammography screening units without adding substantial cost. METHODS: The study was based on the Karma cohort, which included 70,877 participants. Mammograms were collected up to 3 years following the baseline mammogram. A prediction protocol was developed using mammographic density, computer-aided detection of microcalcifications and masses, use of hormone replacement therapy (HRT), family history of breast cancer, menopausal status, age, and body mass index...
March 14, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/28288389/ovarian-ablation-for-premenopausal-breast-cancer-a-review-of-treatment-considerations-and-the-impact-of-premature-menopause
#11
REVIEW
Melica Nourmoussavi, Gary Pansegrau, Jason Popesku, Geoffrey L Hammond, Janice S Kwon, Mark S Carey
Historically, ovarian ablation (OA) was used as therapy for women with recurrent hormone-receptor-positive (HRP) premenopausal breast cancer. With the publication of the SOFT (Suppression of Ovarian Function Trial) and TEXT (Tamoxifen and Exemestane Trial) randomized trials, there is considerable interest in OA as an adjuvant treatment, either in combination with tamoxifen or an aromatase inhibitor (AI). Thus, we have reviewed current guidelines and key studies on this important topic and have highlighted the relevant biological and pharmacological aspects of the various endocrine therapies...
February 22, 2017: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/28286991/cardiovascular-disease-in-women-is-it-different-to-men-the-role-of-sex-hormones
#12
G M C Rosano, I Spoletini, C Vitale
Cardiovascular disease in women differs in clinical presentation, pathophysiology and prognosis from that in men. The role of estrogens and androgens may help explain such sex dimorphisms, being involved in cardiac function, endothelial function and vascular tone. In particular, the cardioprotective effect of estrogen replacement therapy is observed in postmenopausal women in a time-dependent manner, i.e. when it is initiated at their first menopausal symptoms. Postmenopausal women, beyond aged men, may also benefit from testosterone supplementation therapy...
April 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28286987/endometriosis-after-menopause-physiopathology-and-management-of-an-uncommon-condition
#13
I Streuli, H Gaitzsch, J-M Wenger, P Petignat
Endometriosis is a hormone-dependent inflammatory disease that is usually characterized by infertility and pain symptoms. This disease mainly occurs during the reproductive years and is rarely diagnosed after menopause. We discuss the physiopathology of this condition after menopause as well as treatment options and the risk of malignant transformation. Occurrence or progression of postmenopausal endometriosis lesions could be related to extra-ovarian production of estrogen by endometriosis lesions and adipose tissue, which becomes the major estrogen-producing tissue after menopause...
April 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28284896/progesterone-increased-%C3%AE-endorphin-innervation-of-the-locus-coeruleus-but-ovarian-steroids-had-no-effect-on-noradrenergic-neurodegeneration
#14
Fernanda B Lima, Cristiane M Leite, Cynthia L Bethea, Janete A Anselmo-Franci
With the decline of ovarian steroids levels at menopause, many women experience an increase in anxiety and stress sensitivity. The locus coeruleus (LC), a central source of noradrenaline (NE), is activated by stress and is inhibited by β-endorphin. Moreover, increased NE has been implicated in pathological anxiety syndromes. Hormone replacement therapy (HRT) in menopause appears to decrease anxiety and vulnerability to stress. Therefore, we questioned the effect of HRT on the inhibitory β-endorphin innervation of the LC...
March 8, 2017: Brain Research
https://www.readbyqxmd.com/read/28284224/anthropometric-measures-and-serum-estrogen-metabolism-in-postmenopausal-women-the-women-s-health-initiative-observational-study
#15
Hannah Oh, Sally B Coburn, Charles E Matthews, Roni T Falk, Erin S LeBlanc, Jean Wactawski-Wende, Joshua Sampson, Ruth M Pfeiffer, Louise A Brinton, Nicolas Wentzensen, Garnet L Anderson, JoAnn E Manson, Chu Chen, Oleg Zaslavsky, Xia Xu, Britton Trabert
BACKGROUND: Several anthropometric measures have been associated with hormone-related cancers. However, it is unknown whether estrogen metabolism plays an important role in these relationships. We examined whether measured current body mass index (BMI), waist-to-hip ratio (WHR), height, and self-reported BMI at age 18 years were associated with serum estrogens/estrogen metabolites using baseline, cross-sectional data from 1835 postmenopausal women enrolled in the Women's Health Initiative Observational Study...
March 11, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/28281363/the-evidence-base-for-hrt-what-can-we-believe
#16
R D Langer
Prior to the unexpected early termination of the Women's Health Initiative (WHI) trial of continuous conjugated equine estrogens (CEE) and medroxyprogesterone acetate (MPA), the prevailing view was that hormone replacement therapy (HRT) was a low-risk intervention with immediate value for symptom relief in recently menopausal women, and that it probably conferred long-term protection against the major chronic diseases that affect women after menopause. Rather than replicating prior studies, the WHI was designed to test whether the beneficial associations consistently seen in women starting HRT near menopause would be found in women well beyond menopause...
April 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28278011/evaluation-of-trait-and-state-anxiety-levels-in-a-group-of-peri-and-postmenopausal-women
#17
Mónica Flores-Ramos PhD, Roberto Silvestri Tomassoni, José Benjamín Guerrero-López, Margus Salinas
Our objective was to evaluate levels of trait and state anxiety in a group of peri- and postmenopausal women and to explore the relation of hormonal therapy to levels of anxiety. Peri- (n = 63) and postmenopausal (n = 236) women were evaluated between March and September 2013. The assessed variables were menopausal status, anxiety (using the state and trait anxiety inventory), and sociodemographic and clinical variables. Use of psychotropic medications and hormone therapy was also ascertained. The mean age of the participants was 51...
February 16, 2017: Women & Health
https://www.readbyqxmd.com/read/28277141/local-hormone-therapy-for-genitourinary-syndrome-of-menopause-in-breast-cancer-patients-is-it-safe
#18
María Fernanda Garrido Oyarzún, Camil Castelo-Branco
The genitourinary syndrome of menopause (GSM) is a frequent complaint among breast cancer (BC) survivors that lead to an important affection of their quality of life (QoL). Lifestyle measures such as smoking cessation or regular sexual activity are usually insufficient to significantly improve GMS and although therapies such as lubricants and polycarbophil moisturized gels are considered first-line therapies to alleviate symptoms of vulvovaginal atrophy, these non-hormonal options are not able to reverse atrophy once it occurs...
February 21, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28265850/a-general-description-for-chinese-medicine-in-treating-premature-ovarian-failure
#19
Jing Lin, Xue-Lian Li, Hui Song, Qian Li, Ming-Yan Wang, Xue-Min Qiu, Da-Jin Li, Ling Wang
Premature ovarian failure (POF) is a kind of gynecological disease that causes amenorrhea, infertility, menopause and urogenital symptoms. Currently hormone replacement therapy (HRT) is the most popular choice for women with POF to get rid of menopausal syndrome. However, as the popularization of Chinese herbs made Chinese medicine (CM) shine new lights, physicians are able to treat POF with both meno-herbs and integrated therapy. HRT has its own indications and contraindications. For example, unexplained vaginal bleeding, acute liver damage, liver dysfunction, vascular embolization, and breast cancer are all contraindications of HRT, and CM is taken by more physicians as an adjuvant therapy...
February 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28259297/management-of-aromatase-inhibitor-induced-musculoskeletal-symptoms-in-postmenopausal-early-breast-cancer-a-systematic-review-and-meta-analysis
#20
REVIEW
Kate Roberts, Kirsty Rickett, Ristan Greer, Natasha Woodward
Aromatase Inhibitors (AI) are widely used for the adjuvant treatment of hormone receptor positive breast cancers in the post-menopausal population. AI are often associated with significant joint and muscular symptoms; symptoms that are commonly referred to as aromatase inhibitor-associated musculoskeletal syndrome (AIMSS). AIMSS adversely impacts health-related quality of life of many patients, and reduces AI compliance. Although there are informal practice recommendations, the limited current level of evidence for management of AIMSS for breast cancer patients on aromatase inhibitors has made development of formal guidelines challenging, and remains an unmet need...
March 2017: Critical Reviews in Oncology/hematology
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