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https://www.readbyqxmd.com/read/26883688/the-concomitant-use-of-fesoterodine-and-topical-vaginal-estrogen-in-the-management-of-overactive-bladder-and-sexual-dysfunction-in-postmenopausal-women
#1
Bilal Chughtai, James C Forde, Jessica Buck, Tirsit Asfaw, Richard Lee, Alexis E Te, Steven A Kaplan
OBJECTIVE: The objective of this study is to investigate the combination effect of anti-muscarinic medication and topical vaginal estrogen in the treatment of overactive bladder (OAB) and female sexual dysfunction in postmenopausal women. STUDY DESIGN: After IRB approval, 23 female subjects who met the entry criteria were randomized into two groups: (1) fesoterodine (Toviaz®, Pfizer, NY) with topical vaginal estrogen (Premarin®, Pfizer, NY) once daily or (2) fesoterodine once daily alone...
March 2016: Post Reproductive Health
https://www.readbyqxmd.com/read/26793732/comparison-of-the-hyaluronic-acid-vaginal-cream-and-conjugated-estrogen-used-in-treatment-of-vaginal-atrophy-of-menopause-women-a-randomized-controlled-clinical-trial
#2
Azam Jokar, Tayebe Davari, Nasrin Asadi, Fateme Ahmadi, Sedighe Foruhari
BACKGROUND: Vaginal atrophy is a common complication in menopause which does not improve with time and, if untreated, can affect the quality of life for women. The aim of this study was to compare the effectiveness of the vaginal cream of hyaluronic acid and conjugated estrogen (Premarin) in treatment of vaginal atrophy. METHODS: This study was a randomized controlled clinical trial on 56 menopausal women with symptoms of vaginal atrophy; they were randomly allocated to two groups (recipient conjugated estrogen and hyaluronic acid)...
January 2016: International Journal of Community Based Nursing and Midwifery
https://www.readbyqxmd.com/read/26242210/marketplace-analysis-of-conjugated-estrogens-determining-the-consistently-present-steroidal-content-with-lc-ms
#3
Michaella J Levy, Michael T Boyne, Sarah Rogstad, David J Skanchy, Xiaohui Jiang, Ilan Geerlof-Vidavsky
Conjugated estrogens purified from pregnant mares urine has been used as estrogen hormone replacement therapy since 1942. Previously, methods were proposed to identify and quantify the components of this complex mixture but ultimately were withdrawn due to incomplete characterization of the product and difficulties in transferring the method between laboratories. The aim of the current study is to develop a LC method that can reliably detect multiple steroidal components in conjugated estrogen tablets and measure their relative amount...
November 2015: AAPS Journal
https://www.readbyqxmd.com/read/25887391/time-and-dose-dependent-effects-of-labisia-pumila-on-the-bone-strength-of-postmenopausal-osteoporosis-rat-model
#4
Nadia Mohd Effendy, Shahrum Abdullah, Mohd Faridz Mod Yunoh, Ahmad Nazrun Shuid
BACKGROUND: Post-menopausal osteoporosis has long been treated and prevented by estrogen replacement therapy (ERT). Despite its effectiveness, ERT is associated with serious adverse effects. Labisia pumila var. alata (LP) is a herb with potential as an alternative agent to ERT due to its phytoestrogenic, antioxidative and anti-inflammatory effects on bone. This study aimed to determine the effects of LP supplementation on bone biomechanical strength of postmenopausal osteoporosis rat model...
2015: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/25783923/time-and-dose-dependent-effects-of-labisia-pumila-on-the-bone-strength-of-postmenopausal-osteoporosis-rat-model
#5
Nadia Mohd Effendy, Shahrum Abdullah, Mohd Faridz Mod Yunoh, Ahmad Nazrun Shuid
BACKGROUND: Post-menopausal osteoporosis has long been treated and prevented by estrogen replacement therapy (ERT). Despite its effectiveness, ERT is associated with serious adverse effects. Labisia pumila var. alata (LP) is a herb with potential as an alternative agent to ERT due to its phytoestrogenic, antioxidative and anti-inflammatory effects on bone. This study aimed to determine the effects of LP supplementation on bone biomechanical strength of postmenopausal osteoporosis rat model...
December 2015: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/25538882/does-priming-with-sex-steroids-improve-the-diagnosis-of-normal-growth-hormone-secretion-in-short-children
#6
Ashraf Soliman, Ashraf Adel, Aml Sabt, Elkhansa Elbukhari, Hannah Ahmed, Vincenzo De Sanctis
INTRODUCTION: There is still controversy for priming with sex steroid before growth hormone (GH) testing. OBJECTIVE: We studied GH response to stimulation in 92 children >9 years with idiopathic short stature (height standard deviation score [HtSDS]-2). They were divided randomly into two groups. Children in Group 1 (n = 50) were primed with premarin in girls and testosterone in boys and those in Group 2 were not primed (n = 42). All children were tested using standard clonidine test and their serum insulin-like growth factor-I concentration (IGF-I)...
November 2014: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/25526611/targeted-delivery-of-lovastatin-and-tocotrienol-to-fracture-site-promotes-fracture-healing-in-osteoporosis-model-micro-computed-tomography-and-biomechanical-evaluation
#7
Nurul 'Izzah Ibrahim, Mohd Fadhli Khamis, Mohd Faridz Mod Yunoh, Shahrum Abdullah, Norazlina Mohamed, Ahmad Nazrun Shuid
Osteoporosis is becoming a major health problem that is associated with increased fracture risk. Previous studies have shown that osteoporosis could delay fracture healing. Although there are potential agents available to promote fracture healing of osteoporotic bone such as statins and tocotrienol, studies on direct delivery of these agents to the fracture site are limited. This study was designed to investigate the effects of two potential agents, lovastatin and tocotrienol using targeted drug delivery system on fracture healing of postmenopausal osteoporosis rats...
2014: PloS One
https://www.readbyqxmd.com/read/25195641/time-and-dose-dependent-effects-of-labisia-pumila-on-bone-oxidative-status-of-postmenopausal-osteoporosis-rat-model
#8
Nadia Mohd Effendy, Ahmad Nazrun Shuid
UNLABELLED: Postmenopausal osteoporosis can be associated with oxidative stress and deterioration of antioxidant enzymes. It is mainly treated with estrogen replacement therapy (ERT). Although effective, ERT may cause adverse effects such as breast cancer and pulmonary embolism. Labisia pumila var. alata (LP), a herb used traditionally for women's health was found to protect against estrogen-deficient osteoporosis. An extensive study was conducted in a postmenopausal osteoporosis rat model using several LP doses and duration of treatments to determine if anti-oxidative mechanisms were involved in its bone protective effects...
August 2014: Nutrients
https://www.readbyqxmd.com/read/25080117/the-effects-of-labisia-pumila-on-postmenopausal-osteoporotic-rat-model-dose-and-time-dependent-micro-ct-analysis
#9
Nadia Mohd Effendy, Mohd Fadhli Khamis, Ima Nirwana Soelaiman, Ahmad Nazrun Shuid
BACKGROUND: Postmenopausal osteoporosis is best treated and prevented by estrogen replacement therapy (ERT). Although effective, ERT may cause breast cancer, uterine cancer and cardiovascular problems. Labisia pumila var. alata (LP), a herb with phytoestrogenic, antioxidative and anti-inflammatory effects has potential as an ERT alternative. OBJECTIVE: This study aimed to evaluate micro-CT analysis on the effects of LP supplementation on the trabecular microarchitecture of postmenopausal osteoporosis rat model...
2014: Journal of X-ray Science and Technology
https://www.readbyqxmd.com/read/25071850/vagifem-is-superior-to-vaginal-premarin-in-induction-of-endometrial-thickness-in-the-frozen-thawed-cycle-patients-with-refractory-endometria-a-randomized-clinical-trial
#10
Jaleh Zolghadri, Hossein Haghbin, Nasrin Dadras, Shabnam Behdin
BACKGROUND: Embryo transfer to a developed endometrium is an important prognostic factor in frozen-thawed embryo transfer cycle outcome. Vaginal estrogen, such as Vagifem vaginal tablets and Premarin vaginal cream, is a regimen used for the patients with refractive endometria. OBJECTIVE: Our objective was to compare the effects of Vagifem and Premarin on the endometrial thickness of the patients with refractive endometria. MATERIALS AND METHODS: In this randomized clinical trial, 30 patients with refractive endometria in frozen-thawed embryo transfer cycles received Vagifem vaginal tablets and 30 women received Premarin vaginal cream...
June 2014: Iranian Journal of Reproductive Medicine
https://www.readbyqxmd.com/read/24947034/effects-of-preoperative-local-estrogen-in-postmenopausal-women-with-prolapse-a-randomized-trial
#11
RANDOMIZED CONTROLLED TRIAL
David D Rahn, Meadow M Good, Shayzreen M Roshanravan, Haolin Shi, Joseph I Schaffer, Ravinder J Singh, R Ann Word
CONTEXT: Pelvic organ prolapse (POP) increases in prevalence with age; recurrence after surgical repair is common. OBJECTIVE: The objective of the study was to determine the effects of local estrogen treatment on connective tissue synthesis and breakdown in the vaginal wall of postmenopausal women planning surgical repair of POP. DESIGN: This was a randomized trial. SETTING: The study was conducted at an academic tertiary medical center...
October 2014: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/24869857/effects-of-pulsed-electromagnetic-fields-on-the-expression-of-nfatc1-and-caii-in-mouse-osteoclast-like-cells
#12
Jianquan He, Yongsheng Zhang, Jian Chen, Suyu Zheng, Hui Huang, Xiaoyu Dong
BACKGROUND AND AIMS: Pulsed electromagnetic fields (PEMF) have proven to be an effective noninvasive method in the prevention and treatment of osteoporosis. This study evaluated the effects of PEMF on the expression of the NFATc1, CAII and RANK genes in mouse osteoclast-like cells. METHODS: Bone marrow from bilateral tibiae and femurs was cultured in differentiation medium in the presence of soluble macrophage colony stimulating factor (M-CSF) and receptor activator of nuclear factor kappa-B ligand (RANKL)...
February 2015: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/24833553/recent-advances-in-the-pharmacologic-treatment-of-spinal-cord-injury
#13
REVIEW
April Cox, Abhay Varma, Naren Banik
A need exists for the effective treatment of individuals suffering from spinal cord injury (SCI). Recent advances in the understanding of the pathophysiological mechanisms occurring in SCI have resulted in an expansion of new therapeutic targets. This review summarizes both preclinical and clinical findings investigating the mechanisms and cognate pharmacologic therapeutics targeted to modulate hypoxia, ischemia, excitotoxicity, inflammation, apoptosis, epigenetic alterations, myelin regeneration and scar remodeling...
April 2015: Metabolic Brain Disease
https://www.readbyqxmd.com/read/24007208/labisia-pumila-regulates-bone-related-genes-expressions-in-postmenopausal-osteoporosis-model
#14
Siti Noor Fathilah, Norazlina Mohamed, Norliza Muhammad, Isa Naina Mohamed, Ima Nirwana Soelaiman, Ahmad Nazrun Shuid
BACKGROUND: Labisia Pumila var. alata (LPva) has shown potential as an alternative to estrogen replacement therapy (ERT) in prevention of estrogen-deficient osteoporosis. In earlier studies using postmenopausal model, LPva was able to reverse the ovariectomy-induced changes in biochemical markers, bone calcium, bone histomorphometric parameters and biomechanical strength. The mechanism behind these protective effects is unclear but LPva may have regulated factors that regulate bone remodeling...
2013: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/23974785/premarin-the-intriguing-history-of-a-controverisal-drug
#15
Dwight A Vance
Premarin, a complex of conjugated equine estrogens manufactured by Wyeth for use as hormone replacement therapy in women, was originally developed by the Canadian pharmaceutical firm Ayerst, McKenna and Harrison. The name Premarin was coined from pregnant mare urine, from which the estrogen complex was isolated. Although the complete composition of Premarin and its active components remains undisclosed or unknown, Wyeth reports that it contains a mixture of 10 estrogens. The history of Premarin is entangled in a fascinating story of human intrigue involving ingenuity, influence, controversy, animal rights, competition, money, protection of stockholders, government regulatory power, patient rights, emotions, greed, power, personal and professional freedom, state rights, and perhaps even, ultimately, constitutional issues...
July 2007: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/23782654/androgenic-action-of-dehydroepiandrosterone-dhea-on-nerve-density-in-the-ovariectomized-rat-vagina
#16
Georges Pelletier, Johanne Ouellet, Céline Martel, Fernand Labrie
INTRODUCTION: We have recently reported that dehydroepiandrosterone (DHEA) increases the density of nerve fibers in the ovariectomized (OVX) rat vagina. AIM: To better define the mechanism of action of DHEA, we have examined the effect of DHEA, conjugated estrogens (premarin) and the potent blocker of estrogen action acolbifene on the innervation in the lamina propria in the OVX rat vagina. METHODS: Female Sprague-Dawley rats (10-12 weeks old) were used...
August 2013: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/23371528/separation-of-dansylated-17%C3%AE-estradiol-17%C3%AE-estradiol-and-estrone-on-a-single-hplc-column-for-simultaneous-quantitation-by-lc-ms-ms
#17
Szabolcs Szarka, Vien Nguyen, Laszlo Prokai, Katalin Prokai-Tatrai
We show here that baseline separation of dansylated estrone, 17β-estradiol, and 17α-estradiol can be done, contrary to previous reports, within a short run time on a single RP-LC analytical column packed with particles bonded with phenyl-hexyl stationary phase. The chromatographic method coupled with isotope dilution tandem MS offers a simple assay enabling the simultaneous analysis of these analytes. The method employs (13)C-labeled estrogens as internal standards to eliminate potential matrix effects arising from the use of deuterated estrogens...
April 2013: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/23345032/differentiating-isobaric-steroid-hormone-metabolites-using-multi-stage-tandem-mass-spectrometry
#18
Lauren Tedmon, Jeremy S Barnes, Hien P Nguyen, Kevin A Schug
Steroid hormones and their metabolites are currently undergoing clinical trials as potential therapeutics for traumatic brain injury (TBI). To support this work, it is necessary to develop improved procedures for differentiating isobaric species in this compound class. Equilin sulfate (E-S), estrone sulfate (E1-S), 17α-dihydroequilin sulfate (ADHE-S), and 17β-dihydroequilin sulfate (BDHE-S) are primary constituents in hormone replacement therapies, such as Premarin, which are among pharmaceuticals being investigated for TBI treatment...
March 2013: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/23049604/curcumin-protects-against-ovariectomy-induced-bone-changes-in-rat-model
#19
Farida Hussan, Nawwar Ghassan Ibraheem, Taty Anna Kamarudin, Ahmad Nazrun Shuid, Ima Nirwana Soelaiman, Faizah Othman
Osteoporosis is a metabolic disease affecting both men and women especially in postmenopausal women. Curcumin possesses many medicinal properties. In this study, thirty two female Sprague-Dawley rats were used to determine the potential effect of curcumin in prevention of bone loss following ovariectomy. The animals were divided into Sham group, ovariectomised control, ovariectomised treated with curcumin 110 mg/kg and ovariectomised treated with Premarin 100 μg/kg. The treatments were given via daily oral gavages for 60 days...
2012: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/22991574/labisia-pumila-prevents-complications-of-osteoporosis-by-increasing-bone-strength-in-a-rat-model-of-postmenopausal-osteoporosis
#20
Siti Noor Fathilah, Shahrum Abdullah, Norazlina Mohamed, Ahmad Nazrun Shuid
Estrogen replacement therapy (ERT) is the main treatment postmenopausal osteoporosis. However, ERT causes serious side effects, such as cancers and thromboembolic problems. Labisia pumila var. alata (LPva) is a herb with potential as an alternative to ERT to prevent complications of osteoporosis, especially fragility fractures. This study was conducted to determine the effects of LPva on the biomechanical strength of femora exposed to osteoporosis due to estrogen deficiency, using the postmenopausal rat model...
2012: Evidence-based Complementary and Alternative Medicine: ECAM
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