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https://www.readbyqxmd.com/read/29124649/angiotensin-receptor-blockade-a-novel-approach-for-symptomatic-radiation-necrosis-after-stereotactic-radiosurgery
#1
Mudit Chowdhary, Derick Okwan-Duodu, Jeffrey M Switchenko, Robert H Press, Jaymin Jhaveri, Zachary S Buchwald, Jim Zhong, Bhavana V Chapman, Ranjit S Bindra, Joseph N Contessa, Henry S Park, James B Yu, Roy H Decker, Jeffrey J Olson, Nelson M Oyesiku, Ross A Abrams, Hui-Kuo G Shu, Walter J Curran, Ian R Crocker, Kirtesh R Patel
Preclinical evidence suggests angiotensin blockade therapy (ABT) decreases late radiation toxicities. This study aims to investigate the association between ABT and symptomatic radiation necrosis (SRN) following stereotactic radiosurgery (SRS). Resected brain metastases (rBM) and arteriovenous malformation (AVM) patients treated with SRS from 2002 to 2015 were identified. Patients in the ABT cohort were on therapy during SRS and at 1-month follow up. Kaplan Meier method and cumulative incidence model were used to analyze overall survival (OS) and intracranial outcomes...
November 9, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29123104/a-prospective-randomized-trial-of-two-mucin-secretogogues-for-the-treatment-of-dry-eye-syndrome-in-office-workers
#2
Jun Shimazaki, Den Seika, Masamichi Saga, Kazumi Fukagawa, Miki Sakata, Miki Iwasaki, Takashi Okano
The purpose of the study was to compare the two mucin secretogogues, diquafosol (DQS) and rebamipide (RBM), for the treatment of dry eye syndrome (DES) in office workers. Dry eye patients using computers for >4 h/day were randomly assigned treatment with either DQS or RBM. Main outcomes measures included changes in tear film break-up time (TBUT) and subjective symptoms assessed by the Dry Eye-Related Quality of Life Score (DEQS). The subjects had scheduled examinations at 0 and 4 weeks, and the examinations at 2 and 8 weeks were optional...
November 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29077052/long-lasting-insecticide-net-ownership-access-and-use-in-southwest-ethiopia-a-community-based-cross-sectional-study
#3
Dinberu Seyoum, Niko Speybroeck, Luc Duchateau, Patrick Brandt, Angel Rosas-Aguirre
Introduction:A large proportion of the Ethiopian population (approximately 68%) lives in malaria risk areas. Millions of long-lasting insecticide treated nets (LLINs) have been distributed as part of the malaria prevention and control strategy in the country. This study assessed the ownership, access and use of LLNs in the malaria endemic southwest Ethiopia. Methods: A community-based cross-sectional study was conducted in southwest Ethiopia during October-November 2015, including 836 households from sixteen villages around Gilgel-Gibe dam area...
October 27, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29060616/a-separated-feature-learning-based-dbn-structure-for-classification-of-ssmvep-signals
#4
Yaguang Jia, Jun Xie, Guanghua Xu, Min Li, Sicong Zhang, Ailing Luo, Xingliang Han
Signal processing is one of the key points in brain computer interface (BCI) application. The common methods in BCI signal classification include canonical correlation analysis (CCA), support vector machine (SVM) and so on. However, because BCI signals are very complex and valid signals often come with confounded background noise, many current classification methods would lose meaningful information embedded in human EEGs. Otherwise, due to the huge inter-subject variability with respect to characteristics and patterns of BCI signals, there often exists large difference of classification accuracy among different subjects...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29051111/perspectives-on-using-a-multiplex-human-kidney-safety-biomarker-panel-to-detect-cisplatin-induced-tubular-toxicity-in-male-and-female-cynomolgus-monkeys
#5
Yafei Chen, J Dale Thurman, Lewis B Kinter, Russell Bialecki, J Eric McDuffie
Multiplex biomarker panel assays would enable early de-risking of discovery compound related kidney safety liabilities. The objective of this study was to evaluate the usefulness of the Myriad RBM Human KidneyMAP (Multi-Analyte Profile)® v.1.0 panel to detect experimental nephrotoxicity in Cynomolgus monkeys following a single intravenous administration of cisplatin (2.5mg/kg). Urine samples were collected at baseline on day -2; at approximately 4hr post-dose on day 1; and on days 4, 9, 15 and/or 20. Blood samples were collected at predose on day -2; at 4hr post-dose on day 1; and on days 2, 5, 10 and/or 21...
October 16, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29044523/osseointegration-of-zirconia-and-titanium-implants-in-a-rabbit-tibiae-model-evaluated-by-microtomography-histomorphometry-and-fluorochrome-labeling-analyses
#6
R Martins, T M Cestari, R V N Arantes, P S Santos, R Taga, M J Carbonari, R C Oliveira
OBJECTIVES: This study compares the osseointegration of machined-zirconia implants containing yttria (M-Y-TZP) with machined (M-Ti) and resorbable blast media (RBM-Ti) titanium implants. MATERIAL AND METHODS: M-Y-TZP, M-Ti and RBM-Ti implants were randomly placed in rabbit tibiae. Fluorochrome bone labels (tetracycline, alizarin and calcein) were administered at different time periods. After 8 weeks, osseointegration was evaluated in terms of bone-to-implant contact (BIC), new bone area (nBA), remaining cortical bone area (rBA) and temporal quantification of fluorochromes, using micro-CT and histomorphometric analyses...
October 17, 2017: Journal of Periodontal Research
https://www.readbyqxmd.com/read/28990921/implementing-impact-evaluations-of-malaria-control-interventions-process-lessons-learned-and-recommendations
#7
Christine L Hershey, Achuyt Bhattarai, Lia S Florey, Peter D McElroy, Carrie F Nielsen, Yazoume Yé, Erin Eckert, Ana Cláudia Franca-Koh, Estifanos Shargie, Ryuichi Komatsu, Paul Smithson, Julie Thwing, Jules Mihigo, Samantha Herrera, Cameron Taylor, Jui Shah, Eric Mouzin, Steven S Yoon, S René Salgado
As funding for malaria control increased considerably over the past 10 years resulting in the expanded coverage of malaria control interventions, so did the need to measure the impact of these investments on malaria morbidity and mortality. Members of the Roll Back Malaria (RBM) Partnership undertook impact evaluations of malaria control programs at a time when there was little guidance in terms of the process for conducting an impact evaluation of a national-level malaria control program. The President's Malaria Initiative (PMI), as a member of the RBM Partnership, has provided financial and technical support for impact evaluations in 13 countries to date...
September 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28990912/using-rainfall-and-temperature-data-in-the-evaluation-of-national-malaria-control-programs-in-africa
#8
Madeleine C Thomson, Israel Ukawuba, Christine L Hershey, Adam Bennett, Pietro Ceccato, Bradfield Lyon, Tufa Dinku
Since 2010, the Roll Back Malaria (RBM) Partnership, including National Malaria Control Programs, donor agencies (e.g., President's Malaria Initiative and Global Fund), and other stakeholders have been evaluating the impact of scaling up malaria control interventions on all-cause under-five mortality in several countries in sub-Saharan Africa. The evaluation framework assesses whether the deployed interventions have had an impact on malaria morbidity and mortality and requires consideration of potential nonintervention influencers of transmission, such as drought/floods or higher temperatures...
September 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28981878/a-novel-method-to-estimate-lymphocyte-dose-and-application-to-pediatric-and-young-adult-ct-patients-in-the-united-kingdom
#9
Choonsik Lee, Lindsay M Morton, Amy Berrington de Gonzalez
Despite decades of epidemiological research, it remains uncertain whether ionizing radiation can cause lymphomas. Most epidemiological studies of lymphoma risk following non-uniform exposure used dose to red bone marrow (RBM), constituting a small fraction of the lymphocytes, as a surrogate of dose to the lymphocytes. We developed a method to estimate dose to the lymphocytes using the reference distribution of lymphocytes throughout the body and Monte Carlo simulations of computational human phantoms. We applied our method to estimating lymphocyte doses for a pediatric CT patient cohort in the United Kingdom...
July 28, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/28950614/nonequilibrium-thermodynamics-of-restricted-boltzmann-machines
#10
Domingos S P Salazar
In this work, we analyze the nonequilibrium thermodynamics of a class of neural networks known as restricted Boltzmann machines (RBMs) in the context of unsupervised learning. We show how the network is described as a discrete Markov process and how the detailed balance condition and the Maxwell-Boltzmann equilibrium distribution are sufficient conditions for a complete thermodynamics description, including nonequilibrium fluctuation theorems. Numerical simulations in a fully trained RBM are performed and the heat exchange fluctuation theorem is verified with excellent agreement to the theory...
August 2017: Physical Review. E
https://www.readbyqxmd.com/read/28941285/femoral-neck-shaft-angle-and-climate-induced-body-proportions
#11
Stephanie L Child, Libby W Cowgill
OBJECTIVES: Declination in femoral neck-shaft angle (NSA) is commonly linked to an increased level of physical activity during life. More recently, however, research suggests that lower NSA might also be explained, in part, as the mechanical consequence of differences in ecogeographic body proportions. This study tests the proposed link between NSA and climatic-induced body proportions, using relative body mass (RBM), throughout the course of development. MATERIALS AND METHODS: NSA and RBM were collected for 445 immature remains from five geographic locations...
September 23, 2017: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/28937271/assessment-of-radiation-induced-secondary-cancer-risk-in-the-brazilian-population-from-left-sided-breast-3d-crt-using-mcnpx
#12
Bruno Melo Mendes, Bruno Machado Trindade, Telma Cristina Ferreira Fonseca, Tarcisio Passos Ribeiro de Campos
OBJECTIVE: The aim of this work was to simulate a 6MV conventional breast 3D conformational radiation therapy (3D-CRT) with physical wedges (50 Gy/25#) in the left breast, calculate the mean absorbed dose in the body organs using robust models and computational tools and estimate the secondary cancer-incidence risk to the Brazilian population. METHODS: The VW female phantom was used in the simulations. Planning target volume (PTV) was defined in the left breast...
October 27, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28931699/adoption-of-telehealth-remote-biometric-monitoring-among-peritoneal-dialysis-patients-in-the-united-states
#13
Susie Q Lew, Neal Sikka, Clinton Thompson, Teena Cherian, Manya Magnus
We examined participant uptake and utilization of remote monitoring devices, and the relationship between remote biometric monitoring (RBM) of weight (Wt) and blood pressure (BP) with self-monitoring requirements. Participants on peritoneal dialysis (PD) (n = 269) participated in a Telehealth pilot study of which 253 used remote monitoring of BP and 255 for Wt. Blood pressure and Wt readings were transmitted in real time to a Telehealth call center, which were then forwarded to the PD nurses for real-time review...
September 2017: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
https://www.readbyqxmd.com/read/28911098/the-smap2-rna-binding-motif-in-the-3-utr-affects-mrna-stability-in-the-crenarchaeum-sulfolobus-solfataricus
#14
Birgit Märtens, Kundan Sharma, Henning Urlaub, Udo Bläsi
Sm and Sm-like proteins represent an evolutionarily conserved family with key roles in RNA metabolism in Pro- and Eukaryotes. In this study, a collection of 53 mRNAs that co-purified with Sulfolobus solfataricus (Sso) SmAP2 were surveyed for a specific RNA binding motif (RBM). SmAP2 was shown to bind with high affinity to the deduced consensus RNA binding motif (SmAP2-cRBM) in vitro. Residues in SmAP2 interacting with the SmAP2-cRBM were mapped by UV-induced crosslinking in combination with mass-spectrometry, and verified by mutational analyses...
September 6, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28893317/perceived-barriers-and-facilitators-to-risk-based-monitoring-in-academic-led-clinical-trials-a-mixed-methods-study
#15
Caroline Hurley, Carol Sinnott, Mike Clarke, Patricia Kearney, Emmy Racine, Joseph Eustace, Frances Shiely
BACKGROUND: In November 2016, the ICH published a requirement for sponsors to develop a systematic, prioritised, risk-based approach to monitoring clinical trials. This approach is more commonly known as risk-based monitoring (RBM). However, recent evidence suggests that a 'gold standard', validated approach to RBM does not exist and it is unclear how sponsors will introduce RBM into their organisations. A first step needed to inform the implementation of RBM is to explore academic trialists' readiness and ability to perform RBM...
September 11, 2017: Trials
https://www.readbyqxmd.com/read/28889186/local-bone-marrow-exposure-how-to-interpret-the-data-on-stable-chromosome-aberrations-in-circulating-lymphocytes-some-comments-on-the-use-of-fish-method-for-dose-reconstruction-for-techa-riverside-residents
#16
Evgenia I Tolstykh, Marina O Degteva, Alexandra V Vozilova, Lynn R Anspaugh
The method of fluorescence in situ hybridization (FISH) applied to peripheral blood T lymphocytes is used for retrospective dose estimation, and the results obtained from the analysis of stable chromosomal aberrations are usually interpreted as a dose accumulated in the red bone marrow (RBM). However, after local internal exposure of the RBM, doses derived from FISH were found to be lower than those derived from direct measurements of radionuclides accumulated in the bodies of exposed persons. These results were obtained for people residing near the Techa River contaminated by (89,90)Sr (beta-emitters) in 1949-1956 (Chelyabinsk Oblast, Russia)...
November 2017: Radiation and Environmental Biophysics
https://www.readbyqxmd.com/read/28883453/%C3%AE-catenin-twist-and-snail-transcriptional-regulation-of-emt-in-smokers-and-copd-and-relation-to-airflow-obstruction
#17
Malik Quasir Mahmood, Eugene Haydn Walters, Shakti D Shukla, Steve Weston, Hans Konrad Muller, Chris Ward, Sukhwinder Singh Sohal
COPD is characterised by poorly reversible airflow obstruction usually due to cigarette smoking. The transcription factor clusters of β-catenin/Snail1/Twist has been implicated in the process of epithelial mesenchymal transition (EMT), an intermediate between smoking and airway fibrosis, and indeed lung cancer. We have investigated expression of these transcription factors and their "cellular localization" in bronchoscopic airway biopsies from patients with COPD, and in smoking and non-smoking controls. An immune-histochemical study compared cellular protein expression of β-catenin, Snail1 and Twist, in these subject groups in 3 large airways compartment: epithelium (basal region), reticular basement membrane (Rbm) and underlying lamina propria (LP)...
September 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28845090/the-correlation-between-fstl1-expression-and-airway-remodeling-in-asthmatics
#18
Yahui Liu, Tian Liu, Jinxiang Wu, Tao Li, Xingai Jiao, Haiqing Zhang, Jiping Zhao, Junfei Wang, Lin Liu, Liuzhao Cao, Shuo Li, Jiawei Xu, Jianfeng Xu, Xiaohui Ma, Lei Yang, Liang Dong
BACKGROUND: Asthma is characterized by airway remodeling. Follistatin-like protein 1 (FSTL1) is an extracellular glycoprotein. Recent studies suggest that FSTL1 may participate in the pathogenesis of asthma. OBJECTIVES: To analyze the association between FSTL1 and some parameters and inspect the role of FSTL1 in asthma. METHODS: We examined FSTL1 levels in 32 asthmatics and 25 controls. All subjects enrolled had routine blood tests, spirometry, and impulse oscillometry performed...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28831602/plaque-accumulation-on-titanium-disks-with-different-surface-treatments-an-in-vivo-investigation
#19
Enrico Conserva, Luigi Generali, Alberto Bandieri, Francesco Cavani, Francesco Borghi, Ugo Consolo
Implants with rough surfaces are today widely used. It has been speculated that rough surfaces (Ra > 0.2 μm) provide a better "substrate" for retention and accumulation of plaque in terms of area, thickness and colony-forming unit that can eventually lead to peri mucositis and/or peri-implantitis. The aim of this investigation was to evaluate in vivo the plaque accumulation after 48 h on three implant surfaces with different treatments. For this investigation, we used 21 sterilized titanium disks, with a diameter of 8mm and a thickness of 3 mm, provided by the manufacturer: 7 with machined surface, as smooth control, 7 with HA grit sandblasted RBM surface and 7 with Ca(++) incorporated in titanium Xpeed surface...
August 22, 2017: Odontology
https://www.readbyqxmd.com/read/28797252/evaluation-of-community-based-continuous-distribution-of-long-lasting-insecticide-treated-nets-in-toamasina-ii-district-madagascar
#20
Celine Zegers de Beyl, Albert Kilian, Andrea Brown, Mohamad Sy-Ar, Richmond Ato Selby, Felicien Randriamanantenasoa, Jocelyn Ranaivosoa, Sixte Zigirumugabe, Lilia Gerberg, Megan Fotheringham, Matthew Lynch, Hannah Koenker
BACKGROUND: Continuous distribution of insecticide-treated nets (ITNs) is thought to be an effective mechanism to maintain ITN ownership and access between or in the absence of mass campaigns, but evidence is limited. A community-based ITN distribution pilot was implemented and evaluated in Toamasina II District, Madagascar, to assess this new channel for continuous ITN distribution. METHODS: Beginning 9 months after the December 2012 mass campaign, a community-based distribution pilot ran for an additional 9 months, from September 2013 to June 2014...
August 10, 2017: Malaria Journal
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