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https://www.readbyqxmd.com/read/28526986/implementation-of-quality-by-design-for-formulation-of-rebamipide-gastro-retentive-tablet
#1
Jung-Myung Ha, Jeong-Woong Seo, Su-Hyeon Kim, Ju-Young Kim, Chun-Woong Park, Yun-Seok Rhee, Eun-Seok Park
The purpose of the present study was to develop a rebamipide (RBM) gastro-retentive (GR) tablet by implementing quality by design (QbD). RBM GR tablets were prepared using a sublimation method. Quality target product profile (QTPP) and critical quality attributes (CQAs) of the RBM GR tablets were defined according to the preliminary studies. Factors affecting the CQAs were prioritized using failure mode and effects analysis (FMEA). Design space and optimum formulation were established through a mixture design...
May 19, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28511697/immunohistology-and-remodeling-in-fatal-pediatric-and-adolescent-asthma
#2
Kristiina Malmström, Jouko Lohi, Antti Sajantila, Frode L Jahnsen, Merja Kajosaari, Seppo Sarna, Mika J Mäkelä
BACKGROUND: Thickening of reticular basement membrane, increased airway smooth muscle mass and eosinophilic inflammation are found in adult fatal asthma. At the present study the histopathology of fatal paediatric and adolescent asthma is evaluated. METHODS: Post-mortem lung autopsies from 12 fatal asthma cases and 8 non-asthmatic control subjects were examined. Thickness of reticular basement membrane (RBM) and percentage of airway smooth muscle (ASM%) mass area were measured and inflammatory cells were counted...
May 16, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28504950/graph-regularized-restricted-boltzmann-machine
#3
Dongdong Chen, Jiancheng Lv, Zhang Yi
The restricted Boltzmann machine (RBM) has received an increasing amount of interest in recent years. It determines good mapping weights that capture useful latent features in an unsupervised manner. The RBM and its generalizations have been successfully applied to a variety of image classification and speech recognition tasks. However, most of the existing RBM-based models disregard the preservation of the data manifold structure. In many real applications, the data generally reside on a low-dimensional manifold embedded in high-dimensional ambient space...
May 12, 2017: IEEE Transactions on Neural Networks and Learning Systems
https://www.readbyqxmd.com/read/28492548/inhibition-of-ptp1b-disrupts-cell-cell-adhesion-and-induces-anoikis-in-breast-epithelial-cells
#4
Bylgja Hilmarsdottir, Eirikur Briem, Skarphedinn Halldorsson, Jennifer Kricker, Sævar Ingthorsson, Sigrun Gustafsdottir, Gunhild M Mælandsmo, Magnus K Magnusson, Thorarinn Gudjonsson
Protein tyrosine phosphatase 1B (PTP1B) is a well-known inhibitor of insulin signaling pathways and inhibitors against PTP1B are being developed as promising drug candidates for treatment of obesity. PTP1B has also been linked to breast cancer both as a tumor suppressor and as an oncogene. Furthermore, PTP1B has been shown to be a regulator of cell adhesion and migration in normal and cancer cells. In this study, we analyzed the PTP1B expression in normal breast tissue, primary breast cells and the breast epithelial cell line D492...
May 11, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28466197/the-effect-of-ultrafast-fiber-laser-application-on-the-bond-strength-of-resin-cement-to-titanium
#5
Sabit Melih Ates, Fatih Mehmet Korkmaz, Ipek Satıroglu Caglar, Zeynep Yeşil Duymus, Sedanur Turgut, Elif Arslan Bagis
The purpose of this study was to investigate the effect of ultrafast fiber laser treatment on the bond strength between titanium and resin cement. A total of 60 pure titanium discs (15 mm × 2 mm) were divided into six test groups (n = 10) according to the surface treatment used: group (1) control, machining; group (2) grinding with a diamond bur; group (3) ultrafast fiber laser application; group (4) resorbable blast media (RBM) application; group (5) electro-erosion with copper; and group (6) sandblasting...
May 2, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28465472/cancer-stemness-and-metastatic-potential-of-the-novel-tumor-cell-line-k3-an-inner-mutated-cell-of-bone-marrow-derived-mesenchymal-stem-cells
#6
Hui Qian, Xiaoqing Ding, Jiao Zhang, Fei Mao, Zixuan Sun, Haoyuan Jia, Lei Yin, Mei Wang, Xu Zhang, Bin Zhang, Yongmin Yan, Wei Zhu, Wenrong Xu
Mesenchymal stem cells (MSCs) transplantation has been used for therapeutic applications in various diseases. Here we report MSCs can malignantly transform in vivo. The novel neoplasm was found on the tail of female rat after injection with male rat bone marrow-derived MSCs (rBM-MSCs) and the new tumor cell line, K3, was isolated from the neoplasm. The K3 cells expressed surface antigens and pluripotent genes similar to those of rBM-MSCs and presented tumor cell features. Moreover, the K3 cells contained side population cells (SP) like cancer stem cells (CSCs), which might contribute to K3 heterogeneity and tumorigenic capacity...
April 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/28462009/a-resonance-frequency-analysis-of-sandblasted-and-acid-etched-implants-with-different-diameters-a-prospective-clinical-study-during-the-initial-healing-period
#7
Hyun-Joo Kim, Yeun-Kang Kim, Ji-Young Joo, Ju-Youn Lee
PURPOSE: The possibility of immediate or early loading has become popular in implant dentistry. A prerequisite for the immediate or early loading of an implant prosthesis is the achievement of initial stability in the implant. Moreover, in response to clinicians' interest in verifying clinical stability to determine the optimal time point for functional loading, a non-invasive method to assess implant stability has been developed on the basis of resonance frequency analysis (RFA). The primary objective of this study was to monitor the stability of sandblasted, large-grit, and acid-etched (SLA) implants with different diameters during the early phases of healing by RFA...
April 2017: Journal of Periodontal & Implant Science
https://www.readbyqxmd.com/read/28417122/frequency-control-of-protein-translocation-across-an-oscillating-nanopore
#8
Fabio Cecconi, Muhammad Adnan Shahzad, Umberto Marini Bettolo Marconi, Angelo Vulpiani
The translocation of a lipid binding protein (LBP) is studied using a phenomenological coarse-grained computational model that simplifies both chain and pore geometry. We investigated via molecular dynamics the interplay between transport and unfolding in the presence of a nanopore whose section oscillates periodically in time with a frequency ω, a motion often referred to as the radial breathing mode (RBM). We found that the LPB when mechanically pulled into the vibrating nanopore exhibits a translocation dynamics that in some frequency range is accelerated and shows a frequency locking to the pore dynamics...
April 18, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28409983/emergence-of-compositional-representations-in-restricted-boltzmann-machines
#9
J Tubiana, R Monasson
Extracting automatically the complex set of features composing real high-dimensional data is crucial for achieving high performance in machine-learning tasks. Restricted Boltzmann machines (RBM) are empirically known to be efficient for this purpose, and to be able to generate distributed and graded representations of the data. We characterize the structural conditions (sparsity of the weights, low effective temperature, nonlinearities in the activation functions of hidden units, and adaptation of fields maintaining the activity in the visible layer) allowing RBM to operate in such a compositional phase...
March 31, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28383491/bioactivity-of-nanozr-induced-by-alkali-treatment
#10
Mariko Nishizaki, Satoshi Komasa, Yoichiro Taguchi, Hiroshi Nishizaki, Joji Okazaki
In recent years, zirconia has been a recognized implant material in clinical dentistry. In the present study, we investigated the performance of an alkali-modified ceria-stabilized tetragonal ZrO₂ polycrystalline ceramic-based nanostructured zirconia/alumina composite (NANOZR) implant by assessing surface morphology and composition, wettability, bovine serum albumin adsorption rate, rat bone marrow (RBM) cell attachment, and capacity for inducing bone differentiation. NANOZR surfaces without and with alkali treatment served as the control and test groups, respectively...
April 6, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28381600/increased-neutrophil-gelatinase-associated-lipocalin-ngal-promotes-airway-remodelling-in-chronic-obstructive-pulmonary-disease
#11
Yujie Wang, Man Jia, Xiaoyi Yan, Limin Cao, Peter J Barnes, Ian M Adcock, Mao Huang, Xin Yao
Airway remodelling is an important component of chronic obstructive pulmonary disease (COPD). Neutrophil gelatinase-associated lipocalin (NGAL) from neutrophils may drive COPD epithelial-mesenchymal transition (EMT). NGAL expression was quantified in the lungs of COPD patients and bronchoalveolar lavage fluid (BALF) of ozone-treated mice. Reticular basement membrane (RBM) thickness and E-cadherin and α-smooth muscle actin (α-SMA) expression were determined in mice airways. Effects of cigarette smoke extract (CSE) and inflammatory factors on NGAL expression in human neutrophils as well as the effects of NGAL on airway structural cells was assessed...
April 5, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28374993/removable-backbone-modification-method-for-the-chemical-synthesis-of-membrane-proteins
#12
Jia-Bin Li, Shan Tang, Ji-Shen Zheng, Chang-Lin Tian, Lei Liu
Chemical synthesis can produce water-soluble globular proteins bearing specifically designed modifications. These synthetic molecules have been used to study the biological functions of proteins and to improve the pharmacological properties of protein drugs. However, the above advances notwithstanding, membrane proteins (MPs), which comprise 20-30% of all proteins in the proteomes of most eukaryotic cells, remain elusive with regard to chemical synthesis. This difficulty stems from the strong hydrophobic character of MPs, which can cause considerable handling issues during ligation, purification, and characterization steps...
April 4, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28293414/galectin-3-an-early-predictive-biomarker-of-modulation-of-airway-remodeling-in-patients-with-severe-asthma-treated-with-omalizumab-for-36%C3%A2-months
#13
Anna Maria Riccio, Pierluigi Mauri, Laura De Ferrari, Rossana Rossi, Dario Di Silvestre, Louise Benazzi, Alessandra Chiappori, Roberto Walter Dal Negro, Claudio Micheletto, Giorgio Walter Canonica
BACKGROUND: Bronchial asthma is a heterogeneous disease characterized by three cardinal features: chronic inflammation, variable airflow obstruction, and airway hyperresponsiveness. Asthma has traditionally been defined using nonspecific clinical and physiologic variables that encompass multiple phenotypes and are treated with nonspecific anti-inflammatory therapies. Based on the modulation of airway remodeling after 12 months of anti-immunoglobulin E (IgE) treatment, we identified two phenotypes (omalizumab responder, OR; and non-omalizumab responder, NOR) and performed morphometric analysis of bronchial biopsy specimens...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/28291470/comparative-efficacy-of-multiple-variables-of-mesenchymal-stem-cell-transplantation-for-the-treatment-of-neuropathic-pain-in-rats
#14
LiPing Liu, Zhen Hua, Jun Shen, Yan Yin, Jing Yang, Kathleen Cheng, Aijun Liu, Lina Wang, Jianguo Cheng
OBJECTIVES: The current treatment options for neuropathic pain due to nerve injuries are limited and largely unsatisfactory. Mesenchymal stem cell transplantation (MSC) has shown promise as an emerging therapy for neuropathic pain. However, a number of critical parameters, including the sources of cells, the number of cells, and routes of transplantation, need to be elucidated before it can be tested clinically. METHODS: MSCs were isolated from rat bone marrow (rBM-MSCs) and adipose tissue (rAD-MSCs) and characterized by flow cytometry and functional differentiation...
March 2017: Military Medicine
https://www.readbyqxmd.com/read/28287986/deepx-deep-learning-accelerator-for-restricted-boltzmann-machine-artificial-neural-networks
#15
Lok-Won Kim
Although there have been many decades of research and commercial presence on high performance general purpose processors, there are still many applications that require fully customized hardware architectures for further computational acceleration. Recently, deep learning has been successfully used to learn in a wide variety of applications, but their heavy computation demand has considerably limited their practical applications. This paper proposes a fully pipelined acceleration architecture to alleviate high computational demand of an artificial neural network (ANN) which is restricted Boltzmann machine (RBM) ANNs...
March 8, 2017: IEEE Transactions on Neural Networks and Learning Systems
https://www.readbyqxmd.com/read/28259942/high-expression-of-rbm8a-predicts-poor-patient-prognosis-and-promotes-tumor-progression-in-hepatocellular-carcinoma
#16
Rong Liang, Yan Lin, Jia-Zhou Ye, Xue-Xin Yan, Zhi-Hui Liu, Yong-Qiang Li, Xiao-Ling Luo, Hai-Hong Ye
Hepatocellular carcinoma (HCC) is a huge threat for human health worldwide. As a complicated tumor, the molecular basis for HCC development especially metastasis requires exploration. Although RNA binding motif (RBM) proteins are closely related to various cancers, the clinical importance and underlying mechanisms of RBM8A in HCC remain elusive. In this study, we found that RBM8A was highly expressed in HCC tumor tissues compared to normal liver tissues. Overexpression of RBM8A was associated with HbsAg and Edmondson pathological grading...
April 2017: Oncology Reports
https://www.readbyqxmd.com/read/28257704/rbm-online-challenges-ahead-in-scientific-publishing
#17
EDITORIAL
B C J M Fauser
No abstract text is available yet for this article.
March 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28246673/satisfaction-and-improvements-in-peritoneal-dialysis-outcomes-associated-with-telehealth
#18
Manya Magnus, Neal Sikka, Teena Cherian, Susie Q Lew
BACKGROUND AND SIGNIFICANCE: End stage renal disease (ESRD) affects approximately 660,000 persons in the US each year, representing a significant financial burden to the health care system and affected individuals. Telehealth approaches to care offer an important means of reducing costs as well as increasing autonomy for patients. Understanding patient satisfaction with telehealth provides a key towards eventual scalability. MATERIALS AND METHODS: Quarterly surveys were conducted to characterize satisfaction with remote biometric monitoring (RBM) for blood pressure, weight, glucose and peritoneal dialysis (PD)-specific educational online videos for ESRD patients using PD...
March 1, 2017: Applied Clinical Informatics
https://www.readbyqxmd.com/read/28238449/the-feasibility-of-semi-automatically-generated-red-bone-marrow-segmentations-based-on-mr-only-for-patients-with-gynecologic-cancer
#19
Anna Andreychenko, Petra S Kroon, Matteo Maspero, Ina Jürgenliemk-Schulz, Astrid A C De Leeuw, Marnix G E H Lam, Jan J W Lagendijk, Cornelis A T van den Berg
PURPOSE: For patients with cervical cancer the delivery of chemotherapy with radiotherapy improves survival compared with radiotherapy alone. However, high rates of acute hematologic toxicity occur when combining both therapies due to the damage of the red bone marrow (RBM). This study aimed to reduce the radiation damage to the RBM. A tool has been developed for semi-automatic delineation of the red bone marrow based on MR-only. This delineation can be included into the treatment planning process to reduce the volume of RBM irradiated in patients receiving pelvic radiation therapy...
February 23, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28197929/epithelial-mesenchymal-transition-emt-and-non-small-cell-lung-cancer-nsclc-a-mutual-association-with-airway-disease
#20
Malik Quasir Mahmood, Chris Ward, Hans Konrad Muller, Sukhwinder Singh Sohal, Eugene Haydn Walters
NSCLC is a leading cause of morbidity and mortality worldwide. It includes adeno- and squamous cell carcinoma. In the background, COPD and smoking play a vital role in development of NSCLC. Local progression and metastasis of NSCLC has been associated with various mechanisms, but in particular by a process called epithelial mesenchymal transition (EMT), which is implicated in COPD pathogenesis. In this study, we have investigated whether expression of EGFR (activation marker) and S100A4, vimentin and N-cadherin (as EMT) is different both in central and leading edge of NSCLC and to what extent related to EMT activity of both small and large airways, stage and differentiation of NSCLC...
March 2017: Medical Oncology
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