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https://www.readbyqxmd.com/read/27896213/bone-cutting-capacity-and-osseointegration-of-surface-treated-orthodontic-mini-implants
#1
Ho-Young Kim, Sang-Cheol Kim
OBJECTIVE: The objective of the study was to evaluate the practicality and the validity of different surface treatments of self-drilling orthodontic mini-implants (OMIs) by comparing bone cutting capacity and osseointegration. METHODS: Self-drilling OMIs were surface-treated in three ways: Acid etched (Etched), resorbable blasting media (RBM), partially resorbabla balsting media (Hybrid). We compared the bone cutting capacity by measuring insertion depths into artificial bone (polyurethane foam)...
November 2016: Korean Journal of Orthodontics
https://www.readbyqxmd.com/read/27871994/root-bark-of-morus-alba-ameliorates-the-depressive-like-behaviors-in-diabetic-rats
#2
Mei Ye, Yuting Ke, Bingyang Liu, Yanyan Yuan, Fuyan Wang, Shizhong Bu, Yisheng Zhang
Diabetes-induced depression is one of the severe chronic complications of diabetes mellitus. Up to now, there are only a few effective medicines to prevent or manage the co-morbidity of diabetes and depression. The present study was to investigate the effect of root bark of Morus alaba (RBM) on depressive-like behaviors in the diabetic rats established by a high fat diet and a low dose of streptozotocin. Depressive-like behaviors were measured by the open field test, locomotor activity test and forced swimming test...
November 18, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27858555/the-occurrence-of-progressive-bone-loss-around-the-anodized-surface-implants-and-rbm-implants-a-retrospective-cohort-study
#3
Hee-Chang Kim, Shin-Young Park, Min-Su Han, Yong-Moo Lee, Young Ku, In-Chul Rhyu, Yang-Jo Seol
BACKGROUND: This study was performed to evaluate the occurrence of progressive bone loss around implants with different implant surfaces. METHODS: We retrospectively examined 2,517 implants in 903 patients, including 1,147 anodized-surface implants in 454 patients and 1,370 resorbable blasting media (RBM)-surface implants in 449 patients, which were placed from January 2006 to December 2010. Through regular check-up radiographs and records, the presence of progressive bone loss up to more than 50% of the fixture length was investigated...
November 18, 2016: Journal of Periodontology
https://www.readbyqxmd.com/read/27842489/a-novel-phase-variant-of-the-cholera-pathogen-shows-stress-adaptive-cryptic-transcriptomic-signatures
#4
Bliss Lambert, Maheshi Dassanayake, Dong-Ha Oh, Shana B Garrett, Sang-Yeol Lee, Gregg S Pettis
BACKGROUND: In a process known as phase variation, the marine bacterium and cholera pathogen Vibrio cholerae alternately expresses smooth or rugose colonial phenotypes, the latter being associated with advanced biofilm architecture and greater resistance to ecological stress. To define phase variation at the transcriptomic level in pandemic V. cholerae O1 El Tor strain N16961, we compared the RNA-seq-derived transcriptomes among the smooth parent N16961, its rugose derivative (N16961R) and a smooth form obtained directly from the rugose at high frequencies consistent with phase variation (N16961SD)...
November 14, 2016: BMC Genomics
https://www.readbyqxmd.com/read/27815431/leukaemia-mortality-and-low-dose-ionising-radiation-in-the-wismut-uranium-miner-cohort-1946-2013
#5
Michaela Kreuzer, Christina Sobotzki, Nora Fenske, James W Marsh, Maria Schnelzer
OBJECTIVES: To examine the risk of death from leukaemia in relation to occupational chronic low-level external and internal radiation exposure in a cohort of 58 972 former German uranium miners with mortality follow-up from 1946 to 2013. METHODS: The red bone marrow (RBM) dose from low-linear energy transfer (LET) (mainly external γ-radiation) and high-LET (mainly radon gas) radiation was estimated based on a job-exposure matrix and biokinetic/dosimetric models...
November 4, 2016: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/27814835/what-makes-rbm-online-special-the-chief-editor-s-point-of-view
#6
EDITORIAL
Bart C J M Fauser
No abstract text is available yet for this article.
November 2016: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/27807906/activin-a-and-follistatin-in-patients-with-asthma-does-severity-make-the-difference
#7
Anastasia Papaporfyriou, Petros Bakakos, Konstantinos Kostikas, Georgios Papatheodorou, Georgios Hillas, Rodoula Trigidou, Patroklos Katafigiotis, Nikolaos G Koulouris, Spyros A Papiris, Stelios Loukides
BACKGROUND AND OBJECTIVE: Activin A is a pleiotropic cytokine holding a fundamental role in inflammation and tissue remodelling. Follistatin can modulate the bioactivity of activin. We aimed to measure activin A and follistatin in sputum supernatants and bronchoalveolar lavage (BAL) of asthmatic patients and to determine the possible associations with severity as well as with inflammatory and remodelling indices. METHODS: A total of 58 asthmatic patients (33 with severe refractory asthma (SRA)) and 10 healthy controls underwent sputum induction for % cells, activin A, follistatin, eosinophilic cationic protein (ECP), transforming growth factor beta 1 (TGF-β1), IL-13 and IL-8 measurements...
November 2, 2016: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/27796954/using-3d-culture-of-primary-mammary-epithelial-cells-to-define-molecular-entities-required-for-acinus-formation-analyzing-map-kinase-phosphatases
#8
Malgorzata Gajewska, Sara McNally
Three-dimensional (3D) cell cultures on reconstituted basement membrane (rBM) enable the study of complex interactions between extracellular matrix (ECM) components and epithelial cells, which are crucial for the establishment of cell polarity and functional development of epithelia. 3D cultures of mammary epithelial cells (MECs) on Matrigel (a laminin-rich ECM derived from the Engelbreth-Holm-Swarm (EHS) murine tumor) promote interactions of MECs with the matrix via integrins, leading to formation of spherical monolayers of polarized cells surrounding a hollow lumen (acini)...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27795425/recombinant-receptor-binding-domains-of-multiple-mers-coronaviruses-induce-cross-neutralizing-antibodies-against-divergent-human-and-camel-mers-coronaviruses-and-antibody-escape-mutants
#9
Wanbo Tai, Yufei Wang, Craig A Fett, Guangyu Zhao, Fang Li, Stanley Perlman, Shibo Jiang, Yusen Zhou, Lanying Du
: Middle East respiratory syndrome coronavirus (MERS-CoV) binds to cellular receptor dipeptidyl peptidase 4 (DPP4) via spike (S) protein receptor-binding domain (RBD). The RBD contains critical neutralizing epitopes and serves as an important vaccine target. Since RBD mutations occur in different MERS-CoV isolates and antibody-escape mutants, cross-neutralization of divergent MERS-CoV strains by RBD-induced antibodies remains unknown. Here, we constructed four recombinant RBD (rRBD) proteins with single or multiple mutations detected in representative human MERS-CoV strains from the 2012, 2013, 2014 and 2015 outbreaks, respectively, and one rRBD protein with multiple changes derived from camel MERS-CoV strains...
October 19, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27778399/effect-of-substituents-and-initial-degree-of-functionalization-of-alkylated-single-walled-carbon-nanotubes-on-their-thermal-stability-and-photoluminescence-properties
#10
Yutaka Maeda, Yuya Takehana, Jing-Shuang Dang, Mitsuaki Suzuki, Michio Yamada, Shigeru Nagase
Alkylated single-walled carbon nanotubes (SWNTs) have been thermally treated to determine the influence of substituents and the degree of functionalization on their thermal stability and photoluminescence (PL) properties. Alkylated SWNTs were prepared by treating SWNTs with sodium naphthalenide and alkyl bromide. The defunctionalization of the alkylated SWNTs was monitored by absorption and Raman spectra. Selective recovery of the characteristic absorption and radial breathing mode peaks was observed during the thermal treatment, which indicates that the thermal stability of the alkylated SWNTs decreases with increases in SWNT diameter and degree of functionalization...
October 24, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27711454/calculation-of-raman-parameters-of-real-size-zigzag-n-0-single-walled-carbon-nanotubes-using-finite-size-models
#11
Teobald Kupka, Michal Stachów, Leszek Stobiński, Jakub Kaminský
Structural and selected Raman features of pristine single-walled carbon nanotubes (SWCTNs) with diameters from 0.4 to 1.2 nm and total lengths up to 2.15 nm were studied using the density functional theory (DFT) at the UB3LYP/6-31G* level. Models of different lengths (1, 4, 6 and 10 adjacent bamboo-units) of zigzag (n, 0) SWCNTs, for n ranging from 5 to 15, were studied. Highly systematic changes of individual CC bond lengths and angles along the nanotube axis were observed and described for the longest models...
September 14, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27710869/plasma-proteomics-in-cml-patients-before-and-after-initiation-of-tyrosine-kinase-inhibitor-therapy-reveals-induced-th1-immunity-and-loss-of-angiogenic-stimuli
#12
Stina Söderlund, Lisa Christiansson, Inger Persson, Henrik Hjorth-Hansen, Johan Richter, Bengt Simonsson, Satu Mustjoki, Ulla Olsson-Strömberg, Angelica Loskog
BACKGROUND AND AIMS: The simultaneous measurement of many proteins is now possible using multiplex assays. In this pilot study we investigated a total of 124 proteins in plasma from chronic myeloid leukemia (CML) patients with the purpose of identifying proteins that are differently expressed at diagnosis and after tyrosine kinase inhibitor (TKI) treatment initiation. METHODS: Samples were taken from 14 CML patients at diagnosis and after three months of TKI treatment (imatinib or dasatinib)...
September 27, 2016: Leukemia Research
https://www.readbyqxmd.com/read/27684203/how-to-study-basement-membrane-stiffness-as-a-biophysical-trigger-in-prostate-cancer-and-other-age-related-pathologies-or-metabolic-diseases
#13
Mercedes Rodriguez-Teja, Claudia Breit, Mitchell Clarke, Kamil Talar, Kai Wang, Mohammad A Mohammad, Sage Pickwell, Guillermina Etchandy, Graeme J Stasiuk, Justin Sturge
Here we describe a protocol that can be used to study the biophysical microenvironment related to increased thickness and stiffness of the basement membrane (BM) during age-related pathologies and metabolic disorders (e.g. cancer, diabetes, microvascular disease, retinopathy, nephropathy and neuropathy). The premise of the model is non-enzymatic crosslinking of reconstituted BM (rBM) matrix by treatment with glycolaldehyde (GLA) to promote advanced glycation endproduct (AGE) generation via the Maillard reaction...
September 20, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27648514/development-of-skeletal-system-for-mesh-type-icrp-reference-adult-phantoms
#14
Yeon Soo Yeom, Zhao Jun Wang, Thang Tat Nguyen, Han Sung Kim, Chansoo Choi, Min Cheol Han, Chan Hyeong Kim, Jai Ki Lee, Beom Sun Chung, Maria Zankl, Nina Petoussi-Henss, Wesley E Bolch, Choonsik Lee
The reference adult computational phantoms of the international commission on radiological protection (ICRP) described in Publication 110 are voxel-type computational phantoms based on whole-body computed tomography (CT) images of adult male and female patients. The voxel resolutions of these phantoms are in the order of a few millimeters and smaller tissues such as the eye lens, the skin, and the walls of some organs cannot be properly defined in the phantoms, resulting in limitations in dose coefficient calculations for weakly penetrating radiations...
October 7, 2016: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/27648489/solid-state-amorphization-of-rebamipide-and-investigation-on-solubility-and-stability-of-the-amorphous-form
#15
Xinnuo Xiong, Kailin Xu, Shanshan Li, Peixiao Tang, Ying Xiao, Hui Li
Solid-state amorphization of crystalline rebamipide (RBM) was realized by ball milling and spray drying. The amorphous content of samples milled for various time was quantified using X-ray powder diffraction. Crystalline RBM and three amorphous RBM obtained by milling and spray drying were characterized by morphological analysis, X-ray diffraction, thermal analysis and vibrational spectroscopy. The crystal structure of RBM was first determined by single-crystal X-ray diffraction. In addition, the solubility and dissolution rate of the RBM samples were investigated in different media...
October 6, 2016: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/27641969/risk-based-monitoring-rbm-tools-for-clinical-trials-a-systematic-review
#16
Caroline Hurley, Frances Shiely, Jessica Power, Mike Clarke, Joseph A Eustace, Evelyn Flanagan, Patricia M Kearney
INTRODUCTION: In November 2016, the Integrated Addendum to ICH-GCP E6 (R2) will advise trial sponsors to develop a risk-based approach to clinical trial monitoring. This new process is commonly known as risk based monitoring (RBM). To date, a variety of tools have been developed to guide RBM. However, a gold standard approach does not exist. This review aims to identify and examine RBM tools. METHODS: Review of published and grey literature using a detailed search-strategy and cross-checking of reference lists...
September 15, 2016: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/27639720/from-free-energy-to-expected-energy-improving-energy-based-value-function-approximation-in-reinforcement-learning
#17
Stefan Elfwing, Eiji Uchibe, Kenji Doya
Free-energy based reinforcement learning (FERL) was proposed for learning in high-dimensional state and action spaces. However, the FERL method does only really work well with binary, or close to binary, state input, where the number of active states is fewer than the number of non-active states. In the FERL method, the value function is approximated by the negative free energy of a restricted Boltzmann machine (RBM). In our earlier study, we demonstrated that the performance and the robustness of the FERL method can be improved by scaling the free energy by a constant that is related to the size of network...
August 26, 2016: Neural Networks: the Official Journal of the International Neural Network Society
https://www.readbyqxmd.com/read/27624674/thermal-stability-of-oxidized-single-walled-carbon-nanotubes-competitive-elimination-and-decomposition-reaction-depending-on-the-degree-of-functionalization
#18
Yutaka Maeda, Erika Sone, Akane Nishino, Yuri Amagai, Wei-Wei Wang, Michio Yamada, Mitsuaki Suzuki, Jun Matsui, Masaya Mitsuishi, Toshiya Okazaki, Shigeru Nagase
The thermal stability of oxidized single-walled carbon nanotubes (SWNTs) with various degrees of oxidation was investigated. The oxidized SWNTs exhibited lower absorption and radial breathing mode (RBM) peaks and a higher intensity ratio of the D band to the G band (D/G) in their absorption and Raman spectra than those of the pristine SWNTs. After the thermal treatment, the D/G ratio of the oxidized SWNTs almost recovered its original intensity, regardless of the degree of oxidation. The absorption, photoluminescence (PL), and RBM peaks could not recover their original intensities when the oxidation degree was high...
October 17, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27614607/transforming-growth-factor-tgf-%C3%AE-1-and-smad-signalling-pathways-a-likely-key-to-emt-associated-copd-pathogenesis
#19
Malik Q Mahmood, David Reid, Chris Ward, Hans K Muller, Darryl A Knight, Sukhwinder S Sohal, Eugene H Walters
BACKGROUND AND OBJECTIVE: COPD is characterized by poorly reversible airflow obstruction usually due to cigarette smoking. Transforming growth factor (TGF)-β1 has been implicated in the pathogenesis of COPD, and in particular a process called epithelial mesenchymal transition (EMT), which may well be an intermediatory between smoking and both airway fibrosis and lung cancer. The downstream classical or 'canonical' TGF-β1 pathway is via the phosphorylated (p) Smad transcription factor system...
September 11, 2016: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/27579823/biomarkers-predictive-of-exacerbations-in-the-spiromics-and-copdgene-cohorts
#20
Jason D Keene, Sean Jacobson, Katerina Kechris, Gregory L Kinney, Marilyn G Foreman, Claire M Doerschuk, Barry J Make, Jeffrey L Curtis, Stephen I Rennard, R Graham Barr, Eugene R Bleecker, Richard E Kanner, Eric C Kleerup, Nadia N Hansel, Prescott G Woodruff, MeiLan K Han, Robert Paine Iii, Fernando J Martinez, Russell P Bowler, Wanda K O'Neal
RATIONALE: COPD exacerbations are associated with disease progression, higher healthcare cost, and increased mortality. Published predictors of future exacerbations include previous exacerbation, airflow obstruction, poor overall health, home oxygen use, and gastroesophageal reflux. The value of adding blood biomarkers to clinical variables to predict exacerbations remains unproven. METHODS: Subjects from SPIROMICS (n=1544) and COPDGene (n=602) cohorts had 90 plasma or serum candidate proteins measured on study entry using Myriad-RBM multiplex panels...
August 31, 2016: American Journal of Respiratory and Critical Care Medicine
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