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https://www.readbyqxmd.com/read/29768940/risk-based-monitoring-rbm-implementation-challenges-and-potential-solutions
#1
Nimita Limaye, Veena Jaguste
Risk-based monitoring (RBM) has disrupted the clinical trial industry, challenging conventional monitoring norms, business processes, and organizational structures. Endorsed by regulators and leading industry forums, and further driven by escalating drug development costs and enabling technology shifts making data available real time, the industry is moving from a mode of recalcitrance to acceptance. The effective implementation of RBM requires delicately interweaving changes in technology, processes, people, and perspectives...
January 1, 2018: Therapeutic Innovation & Regulatory Science
https://www.readbyqxmd.com/read/29656620/the-effect-of-recombinant-tyrosine-hydroxylase-expression-on-the-neurogenic-differentiation-potency-of-mesenchymal-stem-cells
#2
Gizem Turac, Gokhan Duruksu, Erdal Karaoz
OBJECTIVE: Tyrosine hydroxylase (TH) is a rate-limiting enzyme in dopamine synthesis, making the enhancement of its activity a target for ensuring sufficient dopamine levels. Rat bone marrow mesenchymal stem cells (rBM-MSCs) are known to synthesize TH after differentiating into neuronal cells through chemical induction, but the effect of its ectopic expression on these cells has not yet been determined. This study investigated the effects of ectopic recombinant TH expression on the stemness characteristics of rBM-MSCs...
March 2018: Neurospine
https://www.readbyqxmd.com/read/29649230/lower-serum-iga-is-associated-with-copd-exacerbation-risk-in-spiromics
#3
Nirupama Putcha, Gabriel G Paul, Antoine Azar, Robert A Wise, Wanda K O'Neal, Mark T Dransfield, Prescott G Woodruff, Jeffrey L Curtis, Alejandro P Comellas, M Bradley Drummond, Allison A Lambert, Laura M Paulin, Ashraf Fawzy, Richard E Kanner, Robert Paine, MeiLan K Han, Fernando J Martinez, Russell P Bowler, R Graham Barr, Nadia N Hansel
BACKGROUND: Decreased but measurable serum IgA levels (≤70 mg/dL) have been associated with risk for infections in some populations, but are unstudied in COPD. This study tested the hypothesis that subnormal serum IgA levels would be associated with exacerbation risk in COPD. METHODS: Data were analyzed from 1,049 COPD participants from the observational cohort study SPIROMICS (535 (51%) women; mean age 66.1 (SD 7.8), 338 (32%) current smokers) who had baseline serum IgA measured using the Myriad RBM biomarker discovery platform...
2018: PloS One
https://www.readbyqxmd.com/read/29621087/comparison-of-osseointegration-of-five-different-surfaced-titanium-implants
#4
Serkan Dundar, Ferhan Yaman, Alihan Bozoglan, Tuba Talo Yildirim, Mustafa Kirtay, Muhammet Fatih Ozupek, Gokhan Artas
The topography, chemical features, surface charge, and hydrophilic nature of titanium implant surfaces are crucial factors for successful osseointegration. This study aimed to investigate the bone implant contact (BIC) ratio of titanium dental implants with different surface modification techniques using the rat femoral bone model. Sandblasted and acid washed (SL-AW), sandblasted (SL), resorbable blast material (RBM), microarc (MA), and sandblasted and microarc (SL-MA) surfaces were compared in this study. Forty male Sprague-Dawley rats were used in this study...
April 4, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29620545/endobronchial-biopsy-in-the-final-diagnosis-of-chronic-obstructive-pulmonary-disease-and-asthma-a-clinicopathological-study
#5
Maria Abdulrahim Arafah, Emad Raddaoui, Faisal Al Kassimi, Esam H Alhamad, Ahmed Amer Alboukai, Ahlam Abdullah Alshedoukhy, Abderrahman Ouban
BACKGROUND: Asthma and chronic obstructive pulmonary disease (COPD) are chronic conditions with an increasing prevalence in developing countries. The evaluation of endobronchial biopsies has emerged as a tool to differentiate between both conditions via the measurement of the reticular basement membrane (RBM) thickness with various conclusions drawn from different studies. OBJECTIVES: Compare the thickness of the RBM between asthma and COPD and evaluate other histomorphological features in both groups...
March 2018: Annals of Saudi Medicine
https://www.readbyqxmd.com/read/29614703/potential-risk-of-clonally-expanded-amnion-mesenchymal-stem-cell-transplants-in-contused-spinal-cords
#6
Sankar Venkatachalam, Sridharan Neelamegan, Tetsuhito Okuda, Akiva Marcus, Dale Woodbury, Martin Grumet
OBJECTIVE: Mesenchymal stem/stromal cells (MSC) promote recovery after spinal cord injury (SCI) using adult bone marrow MSC (BM-MSC). Newborn tissues are a convenient source of MSC that does not involve an invasive procedure for cell collection. In this study the authors tested the effects of rat amnion MSC clone (rAM-MSC) in SCI. METHODS: We tested intra-parenchymal injection of a GFP+ rat rAM-MSC clone derived from E18.5 rats in rat SCI and measured behavioral recovery (BBB scores), histology and X-ray opacity...
March 25, 2018: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/29562690/representation-learning-for-class-c-g-protein-coupled-receptors-classification
#7
Raúl Cruz-Barbosa, Erik-German Ramos-Pérez, Jesús Giraldo
G protein-coupled receptors (GPCRs) are integral cell membrane proteins of relevance for pharmacology. The complete tertiary structure including both extracellular and transmembrane domains has not been determined for any member of class C GPCRs. An alternative way to work on GPCR structural models is the investigation of their functionality through the analysis of their primary structure. For this, sequence representation is a key factor for the GPCRs' classification context, where usually, feature engineering is carried out...
March 19, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29469196/the-relationship-between-inflammation-and-remodeling-in-childhood-asthma-a-systematic-review
#8
REVIEW
Jose A Castro-Rodriguez, Sejal Saglani, Carlos E Rodriguez-Martinez, Maria A Oyarzun, Louis Fleming, Andrew Bush
OBJECTIVES: We aimed to perform a systematic review of all studies with direct measurements of both airway inflammation and remodeling in the subgroup of children with repeated wheezing and/or persistent asthma severe enough to warrant bronchoscopy, to address whether airway inflammation precedes remodeling or is a parallel process, and also to assess the impact of remodeling on lung function. METHODS: Four databases were searched up to June 2017. Two independent reviewers screened the literature and extracted relevant data...
February 22, 2018: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29457314/latent-source-mining-in-fmri-via-restricted-boltzmann-machine
#9
Xintao Hu, Heng Huang, Bo Peng, Junwei Han, Nian Liu, Jinglei Lv, Lei Guo, Christine Guo, Tianming Liu
Blind source separation (BSS) is commonly used in functional magnetic resonance imaging (fMRI) data analysis. Recently, BSS models based on restricted Boltzmann machine (RBM), one of the building blocks of deep learning models, have been shown to improve brain network identification compared to conventional single matrix factorization models such as independent component analysis (ICA). These models, however, trained RBM on fMRI volumes, and are hence challenged by model complexity and limited training set...
February 18, 2018: Human Brain Mapping
https://www.readbyqxmd.com/read/29447667/feature-expansion-by-a-continuous-restricted-boltzmann-machine-for-near-infrared-spectrometric-calibration
#10
Peter de Boves Harrington
A modified algorithm for training a restricted Boltzmann machine (RBM) has been devised and demonstrated for improving the results for partial least squares (PLS) calibration of wheat and meat by near-infrared (NIR) spectroscopy. In all cases, the PLS calibrations improved by using the abstract features generated from the RBM so long as the nonlinear mapping increased the dimensionality. The evaluations were validated using bootstrapped Latin partitions (BLPs) with 5 bootstraps and 3-Latin partitions which proved useful because of the statistical learning and random initial conditions of the RBM networks...
June 20, 2018: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29422099/applying-the-results-based-management-framework-to-the-cerca-multi-component-project-in-adolescent-sexual-and-reproductive-health-a-retrospective-analysis
#11
Kathya Cordova-Pozo, Andrea J Hoopes, Freddy Cordova, Bernardo Vega, Zoyla Segura, Arnold Hagens
BACKGROUND: Adolescent sexual and reproductive health (SRH), problems such as unplanned pregnancies are complex and multifactorial, thus requiring multifaceted prevention interventions. Evaluating the impact of such interventions is important to ensure efficiency, effectiveness and accountability for project funders and community members. In this study, we propose Results Based Management (RBM) as a framework for project management, using the Community Embedded Reproductive Health Care for Adolescents (CERCA) as a case study for RBM...
February 8, 2018: Reproductive Health
https://www.readbyqxmd.com/read/29360786/study-on-urban-heat-island-intensity-level-identification-based-on-an-improved-restricted-boltzmann-machine
#12
Yang Zhang, Ping Jiang, Hongyan Zhang, Peng Cheng
Thermal infrared remote sensing has become one of the main technology methods used for urban heat island research. When applying urban land surface temperature inversion of the thermal infrared band, problems with intensity level division arise because the method is subjective. However, this method is one of the few that performs heat island intensity level identification. This paper will build an intensity level identifier for an urban heat island, by using weak supervision and thought-based learning in an improved, restricted Boltzmann machine (RBM) model...
January 23, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29341932/synthetic-extracellular-matrix-mimic-hydrogel-improves-efficacy-of-mesenchymal-stromal-cell-therapy-for-ischemic-cardiomyopathy
#13
Maria Chiara Ciuffreda, Giuseppe Malpasso, Cindy Chokoza, Deon Bezuidenhout, Kyle P Goetsch, Manuela Mura, Federica Pisano, Neil H Davies, Massimiliano Gnecchi
BACKGROUND: Mesenchymal stromal cells (MSC) repair infarcted hearts mainly through paracrine mechanisms. Low cell engraftment limits the release of soluble paracrine factors (SF) over time and, consequently, MSC efficacy. We tested whether a synthetic extracellular matrix mimic, a hydrogel containing heparin (H-HG), could ameliorate MSC engraftment and binding/release of SF, thus improving MSC therapy efficacy. METHODS AND RESULTS: In vitro, rat bone-marrow MSC (rBM-MSC) were seeded and grown into H-HG...
January 13, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29311759/comparison-of-a-microsphere-based-platform-with-a-multiplex-flow-cytometric-assay-for-determination-of-circulating-cytokines-in-the-mouse
#14
Alain Stricker-Krongrad, Catherine Shoemake, Miao Zhong, Jason Liu, Guy Bouchard
Background: Measuring expression profiles of inflammatory biomarkers is important in monitoring the polarization of immune responses; therefore, results should be independent of quantitation methods if they are to be accepted as validated clinical pathology biomarkers. To evaluate effects of differing quantitation methods, the seven major circulating Th1/Th2/Th17 cytokines interleukin 2 (IL-2), interferon γ (IFN-γ), tumor necrosis factor α (TNF-α), IL-4, IL-6, IL-10 and IL-17A were quantified in plasma of lipopolysaccharide (LPS)-treated mice with two different multiplex platforms...
2018: BMC Clinical Pathology
https://www.readbyqxmd.com/read/29289703/enhancing-interpretability-of-automatically-extracted-machine-learning-features-application-to-a-rbm-random-forest-system-on-brain-lesion-segmentation
#15
Sérgio Pereira, Raphael Meier, Richard McKinley, Roland Wiest, Victor Alves, Carlos A Silva, Mauricio Reyes
Machine learning systems are achieving better performances at the cost of becoming increasingly complex. However, because of that, they become less interpretable, which may cause some distrust by the end-user of the system. This is especially important as these systems are pervasively being introduced to critical domains, such as the medical field. Representation Learning techniques are general methods for automatic feature computation. Nevertheless, these techniques are regarded as uninterpretable "black boxes"...
February 2018: Medical Image Analysis
https://www.readbyqxmd.com/read/29274279/rbm10-harmful-or-helpful-many-factors-to-consider
#16
Julie J Loiselle, Leslie C Sutherland
RBM10 is an RNA binding motif (RBM) protein expressed in most, if not all, human and animal cells. Interest in RBM10 is rapidly increasing and its clinical importance is highlighted by its identification as the causative agent of TARP syndrome, a developmental condition that significantly impacts affected children. RBM10's cellular functions are beginning to be explored, with initial studies demonstrating a tumor suppressor role. Very recently, however, contradictory results have emerged, suggesting a tumor promoter role for RBM10...
May 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29258676/a-tumor-necrosis-factor-%C3%AE-and-hypoxia-induced-secretome-therapy-for-myocardial-repair
#17
Kaviyanka Selvasandran, Georges Makhoul, Prashant K Jaiswal, Rishi Jurakhan, Li Li, Khalid Ridwan, Renzo Cecere
BACKGROUND: Poor viability and retention of transplanted bone marrow mesenchymal stem cells (BM-MSC) remains an obstacle in promoting healing after myocardial infarction (MI). This study aimed to understand the migratory, angiogenic, and cardioprotective effects induced by tumor necrosis factor (TNF)-α and hypoxia through rat BM-MSC (rBM-MSC) paracrine secretions, collectively referred to as secretome, after MI. METHODS: Secretome from rBM-MSC cultures treated with various combinations of H9c2 cardiomyoblast-conditioned medium, TNF-α, and hypoxia was initially collected...
March 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29249922/rice-bran-mineral-extract-increases-the-expression-of-anagen-related-molecules-in-human-dermal-papilla-through-wnt-catenin-pathway
#18
Yu-Mi Kim, Soon-Joung Kwon, Hyun-Joon Jang, Young-Kwon Seo
The objective of this study is to evaluate of rice bran mineral extract (RBM) increases the expression of anagen-related molecules in human dermal papilla (DOCs). Four treatment groups were established to evaluate the efficacy of RBM, including a negative control, positive control (ascorbic acid), RBM and ortho-silicic acid (Si(OH)4 ) (OSA) group. Three days after the DPCs were administered the various treatments, western blot analysis showed that type I collagen expression was increased 2.5-fold in the OSA group and 4-fold in the RBM group, and ALP expression was increased 1...
2017: Food & Nutrition Research
https://www.readbyqxmd.com/read/29240098/reduced-basis-boundary-element-method-for-fast-electromagnetic-field-computation
#19
Yating Shi, Xiuguo Chen, Yinyin Tan, Hao Jiang, Shiyuan Liu
In this work, we combine conventional boundary element method (BEM) with the reduced-basis method (RBM) and propose a reduced-basis boundary element method (RB-BEM) to realize efficient modeling for parameterized electromagnetic scattering problems of dielectric scatterers. The RB-BEM allows for splitting the modeling process into a parameter-independent offline part and parameter-dependent online part, and replacing the high-dimensional original model obtained by conventional BEM with a low-dimensional reduced-basis model to improve computational efficiency of the online part...
December 1, 2017: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
https://www.readbyqxmd.com/read/29234748/early-loading-of-maxillary-titanium-implants-with-a-nanostructured-calcium-incorporated-surface-xpeed-5-year-results-from-a-multicentre-randomised-controlled-trial
#20
Giorgio Gastaldi, Maria Gabriella Grusovin, Pietro Felice, Carlo Barausse, Daniela Rita Ippolito, Marco Esposito
PURPOSE: To evaluate clinical safety and effectiveness of a novel calcium-incorporated titanium implant (Xpeed, MegaGen Implant Co. Limited, Gyeongbuk, South Korea). MATERIALS AND METHODS: In total, 60 patients were randomised to receive one to six titanium implants in the maxilla with either calcium-incorporated (Xpeed) or control resorbable blasted media (RBM) surfaces, according to a parallel group design at two centres. Implants were submerged and exposed at three different endpoints in equal groups of 20 patients at 12, 10 and 8 weeks, respectively...
2017: European Journal of Oral Implantology
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