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https://www.readbyqxmd.com/read/28447646/a-130-000-year-old-archaeological-site-in-southern-california-usa
#1
Steven R Holen, Thomas A Deméré, Daniel C Fisher, Richard Fullagar, James B Paces, George T Jefferson, Jared M Beeton, Richard A Cerutti, Adam N Rountrey, Lawrence Vescera, Kathleen A Holen
The earliest dispersal of humans into North America is a contentious subject, and proposed early sites are required to meet the following criteria for acceptance: (1) archaeological evidence is found in a clearly defined and undisturbed geologic context; (2) age is determined by reliable radiometric dating; (3) multiple lines of evidence from interdisciplinary studies provide consistent results; and (4) unquestionable artefacts are found in primary context. Here we describe the Cerutti Mastodon (CM) site, an archaeological site from the early late Pleistocene epoch, where in situ hammerstones and stone anvils occur in spatio-temporal association with fragmentary remains of a single mastodon (Mammut americanum)...
April 26, 2017: Nature
https://www.readbyqxmd.com/read/28428111/reproductive-healthcare-experiences-of-women-with-cerebral-palsy
#2
Katharine Hayward, Angela Y Chen, Elizabeth Forbes, Rachel Byrne, Marcia B Greenberg, Eileen G Fowler
BACKGROUND: Little is known about pregnancy rates in women with disabilities in general and even less is known about women with child-onset disabilities such as cerebral palsy (CP). HYPOTHESIS: We hypothesized that discussions about pregnancy with healthcare providers and pregnancy rates for woman with CP would be related to their functional levels. METHODS: Survey methodology was used to gather information about demographics, function, whether women were asked about their desire for children, pregnancy outcomes, and services offered during pregnancy and postpartum...
April 5, 2017: Disability and Health Journal
https://www.readbyqxmd.com/read/28417318/patient-and-healthcare-professionals-preference-for-brenzys-vs-enbrel-autoinjector-for-rheumatoid-arthritis-a-randomized-crossover-simulated-use-study
#3
Marc Egeth, Jennifer Soosaar, Peter Nash, Denis Choquette, Ricardo Infante, Dena Rosen Ramey, Sevag Sahakian, Angela Lai, Jin Ju Kim, David Wu
INTRODUCTION: Brenzys was developed as an etanercept biosimilar of Enbrel. The aim of this study was to assess preference and perceived ease of use for the new Brenzys autoinjector compared to the currently available marketed Enbrel MYCLIC autoinjector (Australia) and Enbrel SureClick autoinjector (Canada) for the treatment of rheumatoid arthritis (RA). Because RA affects manual dexterity, ease of use of an autoinjector is a particularly important consideration in developing effective self-delivery of long-term courses of therapy...
April 17, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28409763/work-related-musculoskeletal-disorders-among-jordanian-dental-technicians-prevalence-and-associated-factors
#4
Zeid Al-Hourani, Mohammad Nazzal, Yousef Khader, Khader Al Mhdawi, Abdel Rahim Bibars
BACKGROUND: Dental technology is a profession that requires precise manual skills and dexterous handling of small tools. There is an abundance research on work-related musculoskeletal disorders (WMSDs) affecting dentists, dental hygienists and dental assistants, yet very few articles investigated WMSDs among dental technicians. OBJECTIVES: This study aimed to determine the prevalence of WMSDs among Jordanian dental technicians and their associated factors. METHODS: A cross-sectional design was conducted...
April 12, 2017: Work: a Journal of Prevention, Assessment, and Rehabilitation
https://www.readbyqxmd.com/read/28401069/a-novel-restraint-device-for-injection-of-galleria-mellonella-larvae-that-minimizes-the-risk-of-accidental-operator-needle-stick-injury
#5
James P Dalton, Benedict Uy, Simon Swift, Siouxsie Wiles
Larvae of the insect Galleria mellonella are increasingly being used for studying pathogenic microbes and their virulence mechanisms, and as a rapid model for screening novel antimicrobial agents. The larvae (waxworms) are most frequently infected by injection of pathogenic organisms into the haemocoel through the insect's prolegs. The mostly widely used method for restraining the waxworms for injection is by grasping them between the operator's fingers, which puts the operator at risk of needle stick injury, an important consideration when working with highly pathogenic and/or drug-resistant microorganisms...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28392692/antifungal-optical-and-mechanical-properties-of-polymethylmethacrylate-material-incorporated-with-silanized-zinc-oxide-nanoparticles
#6
Krid Kamonkhantikul, Mansuang Arksornnukit, Hidekazu Takahashi
BACKGROUND: Fungal infected denture, which is typically composed of polymethylmethacrylate (PMMA), is a common problem for a denture wearer, especially an elderly patient with limited manual dexterity. Therefore, increasing the antifungal effect of denture by incorporating surface modification nanoparticles into the PMMA, while retaining its mechanical properties, is of interest. AIM OF THE STUDY: This study aimed to evaluate antifungal, optical, and mechanical properties of heat-cured PMMA incorporated with different amounts of zinc oxide nanoparticles (ZnOnps) with or without methacryloxypropyltrimethoxysilane modification...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28366013/do-impairments-predict-hand-dexterity-after-distal-radius-fractures-a-6-month-prospective-cohort-study
#7
Pavlos Bobos, Emily A Lalone, Ruby Grewal, Joy C MacDermid
BACKGROUND: The relationship of routinely measured grip and motion measures may be related to hand dexterity. This has not yet been thoroughly examined following a distal radius fracture (DRF). The purpose of this study was to investigate if impairments in range of motion (ROM) and grip strength predict hand dexterity 6 months following a DRF. METHODS: Patients with DRFs were recruited from a specialized hand clinic. Hand grip was assessed with a J-Tech dynamometer; ROM was measured using standard landmarks and a manual goniometer...
March 1, 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28360957/treatment-of-lower-urinary-tract-symptoms-in-multiple-sclerosis-patients-review-of-the-literature-and-current-guidelines
#8
REVIEW
Shachar Moshe Aharony, Ornella Lam, Jacques Corcos
Multiple sclerosis (MS) is a unique neurological disease with a broad spectrum of clinical presentations that are time- and disease course-related. Lower urinary tract symptoms (LUTS) are highly prevalent in this patient population, with approximately 90% showing some degree of voiding dysfunction and/or incontinence 6-8 years after the initial MS diagnosis. Major therapeutic goals include quality of life improvement and the avoidance of urological complications Owing to the wide divergence of clinical symptoms and disease course, evaluation and treatment differ between patients...
March 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/28358140/a-pilot-study-on-transient-ischemic-stroke-induced-with-endothelin-1-in-the-rhesus-monkeys
#9
PeiMin Dai, Hui Huang, Lin Zhang, Jing He, XuDong Zhao, FuHan Yang, Ning Zhao, JianZhen Yang, LongJiao Ge, Yu Lin, HuaLin Yu, JianHong Wang
Endothelin-1 (ET-1), a vasoconstrictor, has recently been used to induce focal ischemia in rodents and marmoset monkeys. The rhesus monkey, however, has numerous advantages to the rodent and marmoset that make it a superior and irreplaceable animal model for studying stroke in the brain. In the present study, after mapping the preferred hand representation in two healthy male monkeys with intracortical micro-stimulation, ET-1 was microinjected into the contralateral motor cortex (M1) to its preferred hand. The monkeys had been trained in three manual dexterity tasks before the microinjection and were tested for these tasks following the ET-1 injection...
March 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28356630/activities-of-daily-living-and-manual-hand-dexterity-in-persons-with-idiopathic-parkinson-disease
#10
Yoo-Im Choi, Chiang-Soon Song, Byung-Yoon Chun
[Purpose] The purpose of this study was to evaluate the relationship between daily activities and manual dexterity in persons with Parkinson disease. [Subjects and Methods] The study participants were 25 patients with idiopathic Parkinson disease. This study used two clinical tools, the box-and-block test and Schwab and England Activities of Daily Living scale, to investigate the relationship between manual dexterity and Schwab and England Activities of Daily Living score. [Results] A positive correlation was observed between the Schwab and England Activities of Daily Living and the box-and-block test scores on the more and less affected sides...
March 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28344044/impairments-of-motor-function-among-children-with-a-familial-risk-of-schizophrenia-or-bipolar-disorder-at-7-years-old-in-denmark-an-observational-cohort-study
#11
Birgitte Klee Burton, Anne A E Thorup, Jens Richardt Jepsen, Gry Poulsen, Ditte Ellersgaard, Katrine S Spang, Camilla Jerlang Christiani, Nicoline Hemager, Ditte Gantriis, Aja Greve, Ole Mors, Merete Nordentoft, Kerstin Jessica Plessen
BACKGROUND: Owing to the genetic overlap between schizophrenia and bipolar disorder, we aimed to assess domain-specific motor aberrations and disorder specificity among 7-year-old children with a familial risk of schizophrenia or bipolar disorder by comparing children in familial risk groups with each other and with children not in these risk groups. METHODS: In the Danish High Risk and Resilience Study, we established a cohort of 7-year-old children with no, one, or two parents with schizophrenia or bipolar disorder in Denmark between Jan 1, 2013, and Jan 31, 2016...
March 23, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28336344/participation-restriction-in-people-with-multiple-sclerosis-prevalence-and-correlations-with-cognitive-walking-balance-and-upper-limb-impairments
#12
Davide Cattaneo, Ilse Lamers, Rita Bertoni, Peter Feys, Johanna Jonsdottir
OBJECTIVE: To calculate percentage of participation restrictions according to disability level in Multiple Sclerosis (MS) and to assess relationship between participation restriction, and cognitive, gait, balance and upper limb deficits. DESIGN: Cross sectional study SETTING: Rehabilitation unit PARTICIPANTS: 105 people with MS and 20 healthy subjects (HS) were screened in Belgium and Italy. INTERVENTIONS: Not applicable MAIN OUTCOME MEASURES: The Community integration questionnaire was used to assess participation in Home, Social and Productive Activities...
March 21, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28288201/optokinetic-nystagmus-reflects-perceptual-directions-in-the-onset-binocular-rivalry-in-parkinson-s-disease
#13
Mana Fujiwara, Catherine Ding, Lisandro Kaunitz, Julie C Stout, Dominic Thyagarajan, Naotsugu Tsuchiya
Optokinetic nystagmus (OKN), the reflexive eye movements evoked by a moving field, has recently gained interest among researchers as a useful tool to assess conscious perception. When conscious perception and stimulus are dissociated, such as in binocular rivalry-when dissimilar images are simultaneously presented to each eye and perception alternates between the two images over time-OKN correlates with perception rather than with the physical direction of the moving field. While this relationship is well established in healthy subjects, it is yet unclear whether it also generalizes to clinical populations, for example, patients with Parkinson's disease...
2017: PloS One
https://www.readbyqxmd.com/read/28284323/optimizing-drug-delivery-in-copd-the-role-of-inhaler-devices
#14
REVIEW
Paola Rogliani, Luigino Calzetta, Angelo Coppola, Francesco Cavalli, Josuel Ora, Ermanno Puxeddu, Maria Gabriella Matera, Mario Cazzola
Inhaled medication is the cornerstone of the pharmacological treatment for patients with asthma and chronic obstructive pulmonary disease (COPD). Several inhaler devices exist, and each device has specific characteristics to achieve the optimal inhalation of drugs. The correct use of inhaler devices is not granted and patients may incur in mistakes when using pressurized metered-dose inhalers (pMDIs) or dry-powder inhaler (DPIs). The incorrect use of inhaler devices can lead to a poorly controlled disease status...
March 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28275083/unilateral-cerebellothalamic-tract-ablation-in-essential-tremor-by-mri-guided-focused-ultrasound
#15
Sebastian R Schreglmann, Ronald Bauer, Stefan Hägele-Link, Kailash P Bhatia, Parashkev Natchev, Nikolas Wegener, Anita Lebeda, Beat Werner, Ernst Martin, Georg Kägi
OBJECTIVE: To report results of a prospective trial of unilateral transcranial MRI-guided focused ultrasound (MRIgFUS) ablation of the cerebellothalamic tract in essential tremor (ET). METHODS: This was a prospective, uncontrolled, single-center interventional study. Patients with ET fulfilling criteria for interventional therapy received unilateral ablation of the cerebellothalamic tract (CTT) by MRIgFUS. Motor symptoms, manual dexterity, cognition, and quality of life were assessed before intervention and at 48 hours and 1, 3, and 6 months after intervention...
March 8, 2017: Neurology
https://www.readbyqxmd.com/read/28269396/investigation-of-a-passive-capstan-based-grasp-enhancement-feature-in-a-voluntary-closing-prosthetic-terminal-device
#16
Kevin D Gemmell, Michael T Leddy, Joseph T Belter, Aaron M Dollar
Body-powered prosthetic terminal devices fall into two main categories: voluntary-closing devices, which require the user to exert a force to maintain a grasp, and voluntary opening devices, which generally utilize springs to close and maintain a force. As a result, voluntary-closing devices often have a locking feature that allows the user to relax and transport objects while maintaining a firm grip. In this paper, we examine a new type of capstan-based passive brake mechanism in a voluntary-closing prosthetic terminal device...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28240978/evaluation-of-the-self-fitting-process-with-a-commercially-available-hearing-aid
#17
Elizabeth Convery, Gitte Keidser, Mark Seeto, Margot McLelland
BACKGROUND: Hearing aids and personal sound amplification products that are designed to be self-fitted by the user at home are becoming increasingly available in the online marketplace. While these devices are often marketed as a low-cost alternative to traditional hearing health-care, little is known about people's ability to successfully use and manage them. Previous research into the individual components of a simulated self-fitting procedure has been undertaken, but no study has evaluated performance of the procedure as a whole using a commercial product...
February 2017: Journal of the American Academy of Audiology
https://www.readbyqxmd.com/read/28237009/a-new-method-of-ergonomic-testing-of-gloves-protecting-against-cuts-and-stabs-during-knife-use
#18
Emilia Irzmańska, Tomasz Tokarski
The paper presents a new method of ergonomic evaluation of gloves protecting against cuts and stabs during knife use, consisting of five manual dexterity tests. Two of them were selected based on the available literature and relevant safety standards, and three were developed by the authors. All of the tests were designed to simulate occupational tasks associated with meat processing as performed by the gloved hand in actual workplaces. The tests involved the three most common types of protective gloves (knitted gloves made of a coverspun yarn, metal mesh gloves, and metal mesh gloves with an ergonomic polyurethane tightener) and were conducted on a group of 20 males...
May 2017: Applied Ergonomics
https://www.readbyqxmd.com/read/28227639/investigation-of-a-passive-capstan-based-grasp-enhancement-feature-in-a-voluntary-closing-prosthetic-terminal-device
#19
Kevin D Gemmell, Michael T Leddy, Joseph T Belter, Aaron M Dollar, Kevin D Gemmell, Michael T Leddy, Joseph T Belter, Aaron M Dollar, Joseph T Belter, Kevin D Gemmell, Michael T Leddy, Aaron M Dollar
Body-powered prosthetic terminal devices fall into two main categories: voluntary-closing devices, which require the user to exert a force to maintain a grasp, and voluntary opening devices, which generally utilize springs to close and maintain a force. As a result, voluntary-closing devices often have a locking feature that allows the user to relax and transport objects while maintaining a firm grip. In this paper, we examine a new type of capstan-based passive brake mechanism in a voluntary-closing prosthetic terminal device...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28218495/design-and-evaluation-of-a-variable-stiffness-manual-operating-platform-for-laparoendoscopic-single-site-surgery-less
#20
Jinhua Li, Xuejie Li, Jianchen Wang, Yuan Xing, Shuxin Wang, Xiangyun Ren
BACKGROUND: Most of the existing robotic platforms for LESS have workspace and load capacity weaknesses, because of the limitation of one single incision. We have developed a LESS manual operating platform of which the stiffness of the insertion tube is controllable. METHODS: The system included two dexterous tool manipulators, a stereo-vision module and a variable stiffness insertion tube (VSIT), which was designed using phase-change material (mixed indium, gallium and stannum)...
February 20, 2017: International Journal of Medical Robotics + Computer Assisted Surgery: MRCAS
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