Manjulatha Sara, Muhammad Yasir, Parthasarathi Kalaiselvan, Alex Hui, Rajesh Kuppusamy, Naresh Kumar, Sudip Chakraborty, Tsz Tin Yu, Edgar H H Wong, Natalia Molchanova, Håvard Jenssen, Jennifer S Lin, Annelise E Barron, Mark Willcox
BACKGROUND: Ocular infections caused by antibiotic-resistant pathogens can result in partial or complete vision loss. The development of pan-resistant microbial strains poses a significant challenge for clinicians as there are limited antimicrobial options available. Synthetic peptoids, which are sequence-specific oligo-N-substituted glycines, offer potential as alternative antimicrobial agents to target multidrug-resistant bacteria. METHODS: The antimicrobial activity of synthesised peptoids against multidrug-resistant (MDR) ocular pathogens was evaluated using the microbroth dilution method...
February 9, 2024: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association