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Contact lens keratitis

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https://www.readbyqxmd.com/read/28919334/failure-of-molecular-diagnostics-of-a-keratitis-inducing-acanthamoeba-strain
#1
Patrick L Scheid, Carsten Balczun
An otherwise healthy 49-year-old female patient presented at the local hospital with severe keratitis in both inflamed eyes. She was a contact lens wearer and had no history of a corneal trauma. In our laboratory for medical parasitology Acanthamoebae were detected microscopically from the cornea scraping and from the fluid of the contact lens storage case after xenical culture and showed the typical cyst morphology of Acanthamoebae group II. The diagnosis of "Acanthamoeba keratitis" was established and successful therapy was provided...
September 14, 2017: Experimental Parasitology
https://www.readbyqxmd.com/read/28919333/status-of-the-effectiveness-of-contact-lens-disinfectants-in-malaysia-against-keratitis-causing-pathogens
#2
Farhat Abjani, Naveed Ahmed Khan, Suk Yul Jung, Ruqaiyyah Siddiqui
The aim of this study was (i) to assess the antimicrobial effects of contact lens disinfecting solutions marketed in Malaysia against common bacterial eye pathogens and as well as eye parasite, Acanthamoeba castellanii, and (ii) to determine whether targeting cyst wall would improve the efficacy of contact lens disinfectants. Using ISO 14729 Stand-Alone Test for disinfecting solutions, bactericidal and amoebicidal assays of six different contact lens solutions including Oxysept(®), AO SEPT PLUS, OPTI-FREE(®) pure moist(®), Renu(®) fresh™, FreshKon(®) CLEAR and COMPLETE RevitaLens™ were performed using Manufacturers Minimum recommended disinfection time (MRDT)...
September 14, 2017: Experimental Parasitology
https://www.readbyqxmd.com/read/28902722/diagnostic-approach-to-ocular-infections-using-various-techniques-from-conventional-culture-to-next-generation-sequencing-analysis
#3
Hiroshi Eguchi, Fumika Hotta, Tomomi Kuwahara, Haruyuki Imaohji, Chika Miyazaki, Miou Hirose, Shunji Kusaka, Masahiko Fukuda, Yoshikazu Shimomura
Ocular infection is caused by both endogenous (resident) and exogenous (environmental) microbes. As the ocular surface interacts with both outer environment and its own resident microbiota, clinical ocular samples are predicted to contain a diverse set of microorganisms. Microscopy of sample smears is an important step in the diagnostic process of infectious diseases to interpret the culture results. Traditional culture techniques have several limitations in the detection and/or identification of uncharacterized bacteria of environmental origin...
September 11, 2017: Cornea
https://www.readbyqxmd.com/read/28873175/development-of-a-poly-%C3%AE%C2%B5-lysine-contact-lens-as-a-drug-delivery-device-for-the-treatment-of-fungal-keratitis
#4
Andrew G Gallagher, Keri McLean, Rosalind M K Stewart, Don A Wellings, Heather E Allison, Rachel L Williams
Purpose: The purpose of this study was to develop a more efficient drug delivery device to overcome the limitations of current drop therapy for the treatment of fungal keratitis. Methods: Amphotericin B (AmpB), 0 to 30 μg/mL, was associated with a poly-ε-lysine (pεK) hydrogel. Fungicidal effect against Candida albicans was assessed at 18 and 42 hours by optical density (OD600) and growth on agar. Tear film dilution effect was mimicked by storage of AmpB pεK gels in 3...
September 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28844988/risk-factors-demographics-and-clinical-profile-of-acanthamoeba-keratitis-in-melbourne-an-18-year-retrospective-study
#5
Matthew Hao Lee, Robin Geoffrey Abell, Biswadev Mitra, Merv Ferdinands, Rasik B Vajpayee
PURPOSE: To assess incidence, risk factors, presentation and final visual outcome of patients with Acanthamoebakeratitis (AK) treated at the Royal Victorian Eye and Ear Hospital (RVEEH), Melbourne, Australia, over an 18-year period. METHODS: A retrospective review of all cases of AK managed at RVEEH between January 1998 and May 2016 was performed. Data collected included age, gender, affected eye, signs and symptoms, time between symptoms and diagnosis, risk factors, presenting and final visual acuity (VA), investigations, medical treatment, surgical interventions and length of follow-up...
August 27, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28834815/effect-of-multipurpose-solution-combined-with-autophagy-inhibitors-on-adhesion-of-acanthamoeba-trophozoites-to-silicone-hydrogel-contact-lenses
#6
Seung-Mok Lee, Da-In Lee, Sung-Hee Park, Hak-Sun Yu, Ji-Eun Lee, Jong-Soo Lee
PURPOSE: The aim of the study was to evaluate the effect of multipurpose contact lens (CL) solution (MPS) combined with autophagy inhibitors on the adhesion properties of Acanthamoeba castellanii (AC) trophozoites to silicone hydrogel CLs. METHODS: AC trophozoites were inoculated onto discs trimmed from a silicone hydrogel CL with plasma surface treatment. After 18 hours, the number of adherent AC trophozoites on the CL treated with MPS was counted under phase-contrast microscopy...
August 22, 2017: Cornea
https://www.readbyqxmd.com/read/28815736/the-diagnosis-and-management-of-contact-lens-related-microbial-keratitis
#7
REVIEW
Nicole Carnt, Chameen Samarawickrama, Andrew White, Fiona Stapleton
Contact lens-associated microbial keratitis poses a diagnostic dilemma for optometrists on two fronts. The distinction between sterile inflammation and microbial infection is often blurred. In addition, there is a requirement with nearly 50 per cent of the Australian and New Zealand optometric profession being therapeutically endorsed, to distinguish between cases of infection that can be managed in the community verses those that require escalation to public hospitals that have access to laboratory diagnostic tools and advanced imaging techniques, such as in vivo confocal microscopy...
August 16, 2017: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/28813424/risk-factors-and-causative-organisms-in-microbial-keratitis-in-daily-disposable-contact-lens-wear
#8
Fiona Stapleton, Thomas Naduvilath, Lisa Keay, Cherry Radford, John Dart, Katie Edwards, Nicole Carnt, Darwin Minassian, Brien Holden
PURPOSE: This study investigated independent risk factors and causative organisms in microbial keratitis in daily disposable contact lens (CL)-wearers. METHODS: A multisite prospective case-control study was undertaken. Cases were daily disposable CL-wearers attending Moorfields Eye Hospital with microbial keratitis and those reported through a one-year surveillance study in Australia and in New Zealand. A population-based telephone survey identified daily disposable CL-wearing controls...
2017: PloS One
https://www.readbyqxmd.com/read/28747368/fusarium-keratitis-in-germany
#9
Grit Walther, Serena Stasch, Kerstin Kaerger, Axel Hamprecht, Mathias Roth, Oliver A Cornely, Gerd Geerling, Colin R Mackenzie, Oliver Kurzai, Marie von Lilienfeld-Toal
Fusarium keratitis is a destructive eye infection that is difficult to treat and which results in poor outcome. In the tropical and subtropical areas the infection is relatively common and associated with trauma or chronic eye diseases. However, in recent years, an increased incidence has been reported in temperate climate regions. At the German National Reference Center, we observed a steady increase in case numbers since 2014. Here, we present the first German case series of eye infections with Fusarium spp...
July 26, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28708218/microbial-characteristics-of-posttraumatic-infective-keratitis
#10
Blanche X Lim, Victor T C Koh, Manotosh Ray
PURPOSE: To determine the demographics, risk factors, clinical and microbiological characteristics, and treatment outcome of posttraumatic infective keratitis. METHODS: Consecutive patients with posttraumatic infective keratitis presenting to the Ophthalmology Department of a tertiary referral hospital in Singapore between March 2012 and March 2016 were prospectively identified. A standardized data collection form was used to document patient demographics, microbiological diagnosis, antibiotic sensitivity, and pretreatment and posttreatment ocular characteristics...
July 8, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28676340/molecular-and-morphological-characterization-of-acanthamoeba-isolated-from-corneal-scrapes-and-contact-lens-wearers-in-argentina
#11
Rodolfo D Casero, Florencia Mongi, Laura Laconte, Fernando Rivero, Dario Sastre, Aníbal Teherán, Giovanny Herrera, Juan David Ramírez
In this study, we describe the frequency of Acanthamoeba keratitis (AK) in patients that assisted in the Ophthalmology Department and determine the species/genotypes of free living amoebas (FLA) isolates. FLA from Corneal scrapes (CS) and contact lens (CL) wearers were studied by morphological and molecular characterization. A database was constructed with sociodemographic, clinical findings and history of use of CL variables. During January 2000 and September 2016 patients with corneal pathology admitted to the Ophthalmology Service of the University Hospital in Córdoba city, Argentina were included in the study...
July 1, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28664704/human-infections-caused-by-free-living-amoebae
#12
REVIEW
Katarzyna Król-Turmińska, Alina Olender
[b]Abstract Introduction[/b]. Among free-living amoebae that are widely distributed in nature only four genera/species are known as agents of human infections:[i] Acanthamoeba spp., Naegleriafowleri, Balamuthia mandrillaris[/i] and[i] Sappiniapedata[/i]. These amoebae are not well adapted to parasitism, and could exist in the human environment without the need for a host. Infections due to these amoebae, despite low morbidity, are characterized by relatively high mortality rate and pose serious clinical problems...
May 11, 2017: Annals of Agricultural and Environmental Medicine: AAEM
https://www.readbyqxmd.com/read/28656012/pathobiology-and-immunobiology-of-acanthamoeba-keratitis-insights-from-animal-models%C3%A2
#13
REVIEW
Sudha Neelam, Jerry Y Niederkorn
Acanthamoeba keratitis (AK) is a rare but sight-threatening disease caused by pathogenic species of Acanthamoeba. Despite its ubiquitous nature, the incidence of AK is relatively low compared to other forms of infectious keratitis. Although contact lens wear is a major risk factor, exposure to contaminated water and ocular trauma are also associated with AK. Once a patient develops AK the prognosis is very poor unless an aggressive treatment regimen is initiated early. Some of the intriguing features of AK are the lack of immunological memory, resistance of the dormant cyst form to treatment, differences between the pathogenic strains and soil isolates of Acanthamoeba and the unique role of the innate immune system in controlling this disease...
June 2017: Yale Journal of Biology and Medicine
https://www.readbyqxmd.com/read/28626819/comparison-of-bandage-contact-lens-removal-on-the-fourth-versus-seventh-postoperative-day-after-photorefractive-keratectomy-a-randomized-clinical-trial
#14
Mehrdad Mohammadpour, Delaram Shakoor, Hassan Hashemi, Mohamad Aghaie Meybodi, Fateme Rajabi, Pegah Hosseini
PURPOSE: To compare the outcomes of bandage contact lens (BCL) removal on the fourth versus seventh post-operative day following photorefractive keratectomy (PRK). METHODS: This study recruited eyes of patients who underwent PRK surgery. The patients were randomly assigned to 2 groups. In Group 1 BCL was removed on the 4th postoperative day, while in Group 2, BCL was removed on the 7th postoperative day. After BCL removal, patients were asked to express their pain score and eye discomfort...
June 2017: Journal of Current Ophthalmology
https://www.readbyqxmd.com/read/28603237/-contact-lens-related-fusarium-keratitis-a-case-report
#15
Silvia Amadasi, Giovanni Federico Pelliccioli, Paolo Colombini, Annalisa Bonomini, Claudio Farina, Filomena Pietrantonio, Palmino Pedroni
We aim to highlight the key factors for a good outcome of fungal keratitis. We describe a case of contact lens-related Fusarium keratitis in a young girl. After identification of Fusarium spp under direct microscopic examination and in culture, a prolonged treatment with topic natamycin 5% was started and administered for five months with restitutio ad integrum of the eye. Prompt microbiological diagnosis and a specific and prolonged treatment are essential for correct management of Fusarium keratitis.
June 1, 2017: Le Infezioni in Medicina
https://www.readbyqxmd.com/read/28575976/thermosensitive-hydrogel-as-an-in-situ-gelling-antimicrobial-ocular-dressing
#16
S Mohammed, Gurpreet Chouhan, Olachi Anuforom, Megan Cooke, Anna Walsh, Peter Morgan-Warren, Mike Jenkins, Felicity de Cogan
Microbial keratitis is a severe ocular condition and one of the most prevalent causes of corneal scarring and associated blindness worldwide. Risk factors include contact lens use, ocular trauma, ocular surface disease and immunosuppression. Initial clinical management mandates intensive (hourly or more frequent) topical administration of broad spectrum antimicrobial therapy for at least 48h, which may require hospital admission, followed by tailored therapy based on microbiological investigation and the institution of strategies to reduce inflammation and promote healing...
September 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28538612/scleral-contact-lenses-in-an-academic-oculoplastics-clinic-epidemiology-and-emerging-considerations
#17
Harinder S Chahal, Marcela Estrada, Christine W Sindt, Jacob A Boehme, Mark A Greiner, Jeffrey A Nerad, Keith D Carter, Richard C Allen, Erin M Shriver
PURPOSE: To describe the role and efficacy of scleral contact lenses (SCLs) in the treatment of progressive keratopathy in patients who have undergone periocular surgical procedures, to investigate the financial impact of these surgical interventions, and to demonstrate the role of oculoplastic surgery in improving scleral contact lens fit. METHODS: A retrospective medical record review was performed to identify patients who both received SCLs and were examined by the oculoplastics service at the University of Iowa between January 1990 and December 2015...
May 22, 2017: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28520596/fungal-keratitis-associated-with-airborne-organic-debris-and-soft-contacts-lenses-case-reports-and-review-of-the-literature
#18
Michael J Hodkin, Ryan C Gustus
OBJECTIVES: To report two cases of fungal keratitis in soft contact lens wearers who were exposed to environmental mold. METHODS: Case reports, with review of the relevant literature. RESULTS: Two otherwise healthy middle-aged women who were soft contact lens wearers developed fungal keratitis about 1 week after heavy exposure to environmental mold. Culture results showed Aspergillus from one patient and the unusual combination of Trichoderma and Penicillium from the other...
May 16, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/28514244/the-safety-of-soft-contact-lenses-in-children
#19
REVIEW
Mark A Bullimore
PURPOSE: There is increasing interest in fitting children with soft contact lenses. This review collates data from a range of studies to estimate the incidence of complications, specifically corneal infiltrative events and microbial keratitis, in patients under the age of 18 years. METHODS: Peer-review papers were identified using PubMed and the Web of Science. A broad range of studies are summarized including large-scale epidemiological studies of contact lens-related complications, hospital-based case series, long- and short-term prospective studies, and multicenter retrospective studies...
June 2017: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/28489721/tear-cytokine-levels-in-contact-lens-wearers-with-acanthamoeba-keratitis
#20
Nicole Carnt, Vicente M Montanez, Grazyna Galatowicz, Neyme Veli, Virginia Calder
PURPOSE: To determine differences in key tear film cytokines between mild and severe cases of acanthamoeba keratitis (AK) and control contact lens (CL) wearers. METHODS: This was a prospective study of CL wearers with AK attending Moorfields Eye Hospital and control CL wearers from the Institute of Optometry, London. Basal tear specimens were collected by 10-μL capillary tubes (BLAUBRAND intraMark, Wertheim, Germany), and tear protein levels were measured with a multiplex magnetic bead array (Luminex 100; Luminex Corporation, Austin, TX) for cytokines interleukin (IL)-1β, IL-6, IL-8, IL-10, IL-17A, IL-17E, IL-17F, IL-22, and interferon gamma and with enzyme-linked immunosorbent assay (Abcam, Cambridge, United Kingdom) for CXCL2...
July 2017: Cornea
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