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Contact lens keratitis

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https://www.readbyqxmd.com/read/29780912/orbital-implant-exposure-after-acanthamoeba-panophthalmitis
#1
Meredith S Baker, Amanda C Maltry, Nasreen A Syed, Richard C Allen
Purpose: Acanthamoeba is a protozoa that can lead to severe ocular disease and sequelae. Although intraocular Acanthamoeba infection is rare, the following case demonstrates an unusual presentation of recurrent Acanthamoeba infection in a 30 year old contact lens wearing male. Observations: After presenting with recurrent Acanthamoeba keratitis and undergoing various treatments, the patient developed nodular scleritis, which evolved into panophthalmitis, and ultimately, required enucleation...
June 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29730068/biofilm-testing-of-microbiota-an-essential-step-during-corneal-scrap-examination-in-egyptian-acanthamoebic-keratitis-cases
#2
Marwa A Hasby Saad, Haidy S M Khalil
PURPOSE: To detect co-infections in the culture-proven acanthamoebic keratitis (AK) cases, and to test the capability of biofilm formation in the isolated microbiota. The clinical findings, habit of wearing contact lens and in-vitro antibiotic resistance were analyzed further according to the biofilm formation capability. METHODS: After clinical examination, corneal scraps and swabs were taken from 240 clinically suspected AK cases, for Acanthamoeba and microbiological cultures...
May 3, 2018: Parasitology International
https://www.readbyqxmd.com/read/29697492/acanthamoeba-an-overview-of-the-challenges-to-the-development-of-a-consensus-methodology-of-disinfection-efficacy-testing-for-contact-lens-care-products
#3
Jeffrey Brocious, Michelle E Tarver, Denise Hampton, Malvina Eydelman
With the increasing incidence of more pathogens that can cause microbial keratitis (MK), it is necessary to periodically reassess disinfection multipurpose solutions testing requirements to ensure that relevant organisms to challenge them are being used. Current testing protocols have included common pathogens such as Pseudomonas aeruginosa, Staphylococcus aureus, Serratia marcescens, Candida albicans, and Fusarium solani but have omitted less common pathogens such as Acanthamoeba. Specifically, Acanthamoeba sp...
April 24, 2018: Eye & Contact Lens
https://www.readbyqxmd.com/read/29663139/corneal-biopsy-for-diagnosis-of-recalcitrant-microbial-keratitis
#4
Dana Robaei, U-Teng Chan, Pauline Khoo, Svetlana Cherepanoff, Yi-Chiao Li, Jane Hanrahan, Stephanie Watson
PURPOSE: To document the findings of corneal biopsies for progressive microbial keratitis in a large tertiary referral institution. METHODS: A retrospective medical records review of all patients who underwent at least one corneal biopsy for the diagnosis of microbial keratitis at Sydney Eye Hospital, Australia between January 1, 2010 and December 31, 2016 was performed. RESULTS: Thirty-eight patients (18 men and 20 women) underwent a corneal biopsy for progressive microbial keratitis unresponsive to broad-spectrum topical antimicrobials...
April 16, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29643799/optical-coherence-tomography-examination-of-the-anterior-segment-in-a-case-of-corneal-perforation-and-lens-trauma-by-chestnut-burr
#5
Takashi Ono, Yosai Mori, Ryohei Nejima, Takuya Iwasaki, Shiro Amano, Kazunori Miyata
Chestnut burrs, the thorny encapsulation of chestnut fruit, can sometimes cause corneal injuries and ulceration, with poor prognoses. We report a case of corneal perforation and damaged anterior lens capsule due to a chestnut burr, using anterior segment optical coherence tomography (AS-OCT). A 67-year-old woman with a chestnut burr injury in her right eye was referred to our hospital. Her right best-corrected visual acuity (BCVA) was 0.8. Slit-lamp examination and AS-OCT showed perforation involving the endothelial layer at the center of the cornea...
January 2018: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/29642830/-a-new-strategy-for-enhancing-acanthamoebicidal-activity-with-synthesis-of-nanoflower-of-laurocerausus-officinalis-roemer-cherry-laurel-fruit-extracts
#6
Ayşe Baldemir, Ülkü Karaman, Sadi Yusufbeyoğlu, Ayşe Eken, Nilay Ildız, Selen İlgün, Cemil Çolak, Gamze Kaçmaz, İsmail Öçsoy, Soner Çankaya
Pathogenic Acanthamoeba species often cause infection known as Acanthamoeba keratitis among people who use contact lenses. It is a type of infection that can result in corneal ulceration, visual loss or even blindness, if not treated. There are various therapeutic options available in the treatment of Acanthamoeba infections but they are usually tough treatments with limited efficacy. For instance, hydrogen peroxide (H2 O2 ) is a commonly used contact lens disinfectant which is effective against Acanthamoeba but it is toxic to the cornea...
January 2018: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/29625485/atovaquone-impairs-growth-of-aspergillus-and-fusarium-keratitis-isolates-by-modulating-mitochondrial-function-and-zinc-homeostasis
#7
Heather L Clark, Martin S Minns, Yan Sun, Tristan de Jesus, Mahmoud G Ghannoum, Eric Pearlman
Purpose: Aspergillus and Fusarium molds cause blinding corneal infections as a consequence of ocular trauma and in association with contact lens wear. As these fungi require zinc for fungal growth, we examined the effect of atovaquone, a ubiquinone analog that disrupts zinc homeostasis, on fungal growth in vitro and in vivo. Methods: In vitro: Aspergillus and Fusarium germinating conidia were incubated overnight with atovaquone, and hyphal growth was measured by fluorimetry...
March 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29625097/chloroquine-as-a-possible-disinfection-adjunct-of-disinfection-solutions-against-acanthamoeba
#8
Eun-Kyung Moon, Seungeun Lee, Fu-Shi Quan, Hyun-Hee Kong
Acanthamoeba keratitis is commonly encountered by contact lens wearers. Contact lens solution plays an important role in the safe use of contact lenses. The most popular products for disinfecting lenses are multipurpose disinfecting solutions (MPDS). However, almost all MPDS retailed in Korea are ineffective in killing Acanthamoeba. The objective of this study was to determine the possibility of using autophagy inhibitor chloroquine as a disinfecting agent to improve the amoebicidal activity of MPDS against Acanthamoeba, especially the cyst...
April 3, 2018: Experimental Parasitology
https://www.readbyqxmd.com/read/29580956/the-use-of-miltefosine-in-the-management-of-refractory-acanthamoeba-keratitis
#9
Shokufeh Tavassoli, Miranda Buckle, Derek Tole, Peter Chiodini, Kieren Darcy
Acanthamoeba keratitis (AK) is a sight threatening infection most commonly affecting contact lens wearers. The authors report a case of intractable A.polyphaga and A.castellanii, with extensive intraocular spread, managed using oral miltefosine. A 59-year old male contact lens wearer was referred to the tertiary corneal service at Bristol Eye Hospital. Vision was hand movements on the left and 6/6 on the right. Clinical examination was consistent with left AK (confirmed by corneal scrape). Management included biguanide (polyhexamethylene biguanide (PHMB) 0...
March 23, 2018: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/29554009/case-report-acanthamoeba-keratitis-management-in-a-first-trimester-pregnant-patient
#10
Francisco de Borja Domínguez-Serrano, Manuel Caro-Magdaleno, Rafael Perea-Pérez, Enrique Rodríguez-de-la-Rúa, Jesús Montero-Iruzubieta
SIGNIFICANCE: Lacrimal punctal plugs may prevent the teratogenicity of the treatment used in infectious keratitis. Its use should be strongly considered in these cases. PURPOSE: We present the case of a 7-week pregnant patient with Acanthamoeba keratitis. CASE REPORT: The patient was a contact lens user with photophobia, redness, and intense pain in the right eye that started 2 weeks earlier. Corrected visual acuity was 20/63 (0.5 logMAR)...
April 2018: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/29505068/regional-spread-of-contact-lens-related-acanthamoeba-keratitis-in-italy
#11
Alberto Antonelli, Eleonora Favuzza, Angelo Galano, Margherita Montalbano Di Filippo, Nunziata Ciccone, Federica Berrilli, Rita Mencucci, David Di Cave, Gian Maria Rossolini
Acanthamoeba ocular infections, known as Acanthamoeba keratitis, are an emerging problem among contact lens wearers. Infections mediated by Acanthamoeba are uncommon, but they can be underestimated due to poor awareness and delayed diagnosis. The routine use of rapid and cost-effective molecular methods like Real Time PCR for the diagnosis of this important pathogen could improve diagnosis and therapy outcome. This report describes the detection by Real Time PCR assay of six T4 and one T3 Acanthamoeba infections, as the first reported cases in Tuscany, Italy...
January 2018: New Microbiologica
https://www.readbyqxmd.com/read/29471697/first-report-of-acanthamoeba-genotype-t8-human-keratitis
#12
Erika Orosz, Nóra Szentmáry, Huba J Kiss, Ágnes Farkas, István Kucsera, Zoltán Zsolt Nagy
Acanthamoeba has a worldwide distribution in the environment and it is capable of causing a painful sight-threatening disease of the cornea designated as Acanthamoeba keratitis (AK). Nowadays, the cases of AK have surged all over the world along with its disease burden due to increasing use of contact lenses used not only for optical correction but also for cosmetic purposes. In our present work, epithelial abrasion of a 27-year-old female soft contact lens wearer with keratitis was examined. Genotype identification was carried out with a real-time fluorescence resonance energy transfer polymerase chain reaction (PCR) assay based on sequence analysis of the 18S rRNA gene...
March 1, 2018: Acta Microbiologica et Immunologica Hungarica
https://www.readbyqxmd.com/read/29436623/development-of-uracil-dna-glycosylase-supplemented-loop-mediated-isothermal-amplification-coupled-with-nanogold-probe-udg-lamp-aunp-for-specific-detection-of-pseudomonas-aeruginosa
#13
Orapan Manajit, Siwaporn Longyant, Paisarn Sithigorngul, Parin Chaivisuthangkura
Pseudomonas aeruginosa (P. aeruginosa) is an important opportunistic pathogen that causes serious infections in humans, including keratitis in contact lens wearers. Therefore, establishing a rapid, specific and sensitive method for the identification of P. aeruginosa is imperative. In the present study, the uracil-DNA-glycosylase-supplemented loop-mediated isothermal amplification combined with nanogold labeled hybridization probe (UDG-LAMP-AuNP) was developed for the detection of P. aeruginosa. UDG-LAMP was performed to prevent carry over contamination and the LAMP reactions can be readily observed using the nanogold probe...
April 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29426444/eyeprintpro-therapeutic-scleral-contact-lens-indications-and-outcomes
#14
Michael T B Nguyen, Vishakha Thakrar, Clara C Chan
OBJECTIVE: To describe indications and outcomes of patients fitted with the EyePrintPRO therapeutic scleral lens. METHODS: A database search of patients fitted with the EyePrintPRO from 2014 to 2016. Fourteen eyes of 10 patients were reviewed retrospectively. Patient demographics, medical and ocular history, indications for fitting, duration of wear, symptoms, and best-corrected visual acuity (BCVA) were analyzed. RESULTS: Mean age at lens fitting was 49 years (range, 21-67 years)...
February 2018: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/29417444/corneal-perforation-after-noncontact-tonometry-in-patients-with-active-recurrent-herpes-simplex-keratitis-case-report
#15
Napaporn Tananuvat, Atitaya Apivatthakakul, Chulaluck Tangmonkongvoragul
PURPOSE: To report iatrogenic complications and to review the potential complications caused by noncontact tonometry (NCT) in related literature. METHODS: This case report describes two cases of active recurrent herpes simplex keratitis (HSK) on top of a thin corneal scar. The cornea was perforated by the air pulse from the NCT, resulting in an air bubble in the anterior chamber. RESULTS: Both patients were diagnosed with active recurrent necrotizing stromal HSK on top of a thinned corneal scar after previous therapeutic treatment involving tissue adhesive glue with a bandage contact lens (BCL) to treat a perforated cornea...
February 7, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/29412494/the-rising-tide-of-acanthamoeba-keratitis-in-auckland-new-zealand-a-7-year-review-of-presentation-diagnosis-and-outcomes-2009-2016
#16
James McKelvie, Moaz Alshiakhi, Mohammed Ziaei, Dipika V Patel, Charles Nj McGhee
IMPORTANCE: Acanthamoeba is an increasingly prevalent cause of vision-threatening microbial keratitis. BACKGROUND: To assess the incidence, clinical presentation, diagnosis and outcomes of patients with Acanthamoeba keratitis (AK) in Auckland, New Zealand over a 7-year period. DESIGN: Retrospective observational consecutive case series. PARTICIPANTS: Fifty-eight eyes of 52 patients diagnosed with AK. METHODS: All cases of AK were identified using a cross-referenced search of clinical, laboratory and pharmacy records from March 2009 to May 2016...
February 7, 2018: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/29408828/clinical-features-antibiotic-susceptibility-profile-and-outcomes-of-infectious-keratitis-caused-by-stenotrophomonas-maltophilia
#17
Sotiria Palioura, Allister Gibbons, Darlene Miller, Terrence P OʼBrien, Eduardo C Alfonso, Oriel Spierer
PURPOSE: Stenotrophomonas maltophilia, an uncommon cause of infectious keratitis, is difficult to treat because of its resistance to multiple antibiotics. The purpose of this study is to describe the clinical features, antibiotic susceptibility profile, and outcomes of S. maltophilia keratitis. METHODS: A retrospective review of records from 1987 to 2016 identified 26 eyes of 26 patients who were treated at the Bascom Palmer Eye Institute for an S. maltophilia corneal ulcer...
March 2018: Cornea
https://www.readbyqxmd.com/read/29390396/acute-keratoconjunctivitis-due-to-contamination-of-contact-lens-care-solution-with-histamine-producing-raoultella-species-a-case-report
#18
Hiroshi Eguchi, Fumika Hotta, Tomomi Kuwahara, Haruyuki Nakayama-Imaohji, Shunji Kusaka, Yoshikazu Shimomura
RATIONALE: Contact lens storage cases are known to be contaminated by a significant number of bacteria. However, histamine-producing Raoultella species has not been reported to contaminate contact lens storage case. PATIENT CONCERNS: A 27-year-old woman with keratoconjunctivitis that developed in the left eye owing to a cosmetic contact lens and poor hygiene was referred to our hospital. The corrected visual acuity was hand motion. DIAGNOSES: Corneal infection other than Acanthamoeba keratitis (AK) and corneal hypoxia were excluded...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29371064/metagenomic-analysis-for-detecting-fusarium-solani-in-a-case-of-fungal-keratitis
#19
Chika Shigeyasu, Masakazu Yamada, Kotaro Aoki, Yoshikazu Ishii, Kazuhiro Tateda, Takashi Yaguchi, Yukinobu Okajima, Yuichi Hori
PURPOSE: To report a difficult-to-identify case of keratitis due to Fusarium solani, diagnosed with the help of exhaustive gene analysis. CASE: A 47-year-old woman attended our hospital with a refractory corneal ulcer associated with contact lens wear in her left eye that had appeared two weeks earlier. On her initial visit, slit lamp examination revealed a small double-ringed irregular hyphate ulcer in the center of the cornea, which had no epithelial defect, suggesting fungal infection...
January 20, 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29369234/in-vitro-evaluation-of-a-hypochlorous-acid-hygiene-solution-on-established-biofilms
#20
Eric G Romanowski, Nicholas A Stella, Kathleen A Yates, Kimberly M Brothers, Regis P Kowalski, Robert M Q Shanks
OBJECTIVES: The purpose of this study was to determine whether a commercial formulation of hypochlorous acid hygiene solution (0.01%), Avenova, can destroy existing biofilms formed by ocular clinical bacterial isolates, including blepharitis isolates of Staphylococcus aureus and coagulase-negative staphylococci, and a keratitis isolate of Pseudomonas aeruginosa. METHODS: Biofilms grown in bacterial growth media on disposable contact lens cases were challenged with hypochlorous acid hygiene solution...
January 15, 2018: Eye & Contact Lens
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