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Tomoki Ryu, Yuko Takami, Norifumi Tsutsumi, Masaki Tateishi, Kazuhiro Mikagi, Yoshiyuki Wada, Hideki Saitsu
PURPOSE: To establish the efficacy and safety of simultaneous microwave coagulo-necrotic therapy (MCN) and laparoscopic splenectomy (Lap-Sp) for the treatment of hepatocellular carcinoma (HCC) with cirrhotic hypersplenism. METHODS: Seventeen patients with HCC and cirrhotic hypersplenism underwent simultaneous MCN and Lap-Sp at our institution between January, 2010 and July, 2015. Eight and nine patients had Child-Pugh class A and B liver cirrhosis, respectively...
August 30, 2016: Surgery Today
Yoshiyuki Wada, Yuko Takami, Masaki Tateishi, Tomoki Ryu, Kazuhiro Mikagi, Hideki Saitsu
BACKGROUND: Five or more colorectal liver metastases (CRLM) are considered marginally resectable and cannot be treated solely by hepatic resection (Hr). This study investigated the long-term effectiveness of surgical treatment using microwave coagulo-necrotic therapy (MCN) and/or Hr for marginally resectable or unresectable multiple CRLM. METHODS: This study retrospectively analyzed 82 consecutive CRLM patients with ≥5 CRLM who underwent MCN, Hr, or both, at our institution from 1994 to 2012...
2016: OncoTargets and Therapy
Yuko Takami, Tomoki Ryu, Yoshiyuki Wada, Hideki Saitsu
BACKGROUND: Hepatic resection (HRx) or radiofrequency ablation may be carried out as the first-line treatment of hepatocellular carcinoma (HCC). However, we have used intraoperative microwave ablation, named microwave coagulo-necrotic therapy (MCN) as part of our strategy for the treatment of HCCs for more than 15 years. Here we describe the treatment outcomes achieved at our institution as a high-volume center for microwave ablation. METHODS: Between July 1994 and December 2010, 719 consecutive patients received MCN as their initial therapy for HCC (mean tumor size 26...
March 2013: Journal of Hepato-biliary-pancreatic Sciences
D Lasne, C Dey, M-D Dautzenberg, Z Cherqaoui, F Monge, A Aouba, M-F Torchet, D Geloen, P Landais, C Rothschild
Measuring von Willebrand factor (VWF) activity is essential to the diagnosis of von Willebrand disease (VWD). The VWF activity is usually assessed based on measurement of the ristocetin cofactor (VWF:RCo). However, that test is technically challenging and has high intra- and inter-assay variabilities. The HemosIL VWF activity (VWF:AC) is a fully automated assay, recently proposed as a good alternative to VWF:RCo for VWD diagnosis. This study was undertaken to assess this new method. First, the analytical performance of VWF:AC on an automated coagulo-meter (ACLTop) was determined, and then this new method was compared with VWF:RCo and the platelet function analyzer (PFA100) for 160 patients referred for VWD screening...
May 2012: Haemophilia: the Official Journal of the World Federation of Hemophilia
Jon A Schwartz, Roger E Price, Kelly L Gill-Sharp, Krystina L Sang, Jennifer Khorchani, Bradford S Goodwin, J Donald Payne
BACKGROUND AND OBJECTIVES: Prostate cancer is the most frequent cancer type and the second most common cause of cancer death among US men. This study, adapted a previously reported nanoparticle-directed photothermal treatment of brain tumors to the treatment of prostate disease by using normal canine prostate in vivo, directly injected with a suspension of nanoparticles as a proxy for prostate tumor, and by developing laser dosimetry for prostate which is marginally ablative in native tissue, yet producing photothermal coagulation in prostate tissue containing nanoparticles...
March 2011: Lasers in Surgery and Medicine
Fujio Fujiki, Yoshio Tsuboi, Tatsuo Yamada
A 33-year-old woman suffering from endometriosis was admitted to our hospital because of acute-onset diplopia and gait instability. She had a low-grade fever and cough 7 days before admission. On admission, she had left eye deviation downward on the inside, bilateral upper gaze impairment, and left Barrés sign with myoclonic-like movement of the left hand. MRI with diffusion-weighted images (DWI) showed high signal intensity in the right thalamus. The lesion had low signal intensity on an apparent diffusion coefficient (ADC) map, indicating cytotoxic edema...
May 2007: Rinshō Shinkeigaku, Clinical Neurology
O L Belaia, N V Fedorova
The subjects of the study were 30 patients with coronary heart disease (19--with stable, and 11--with instable angina), and 15 practically healthy individuals. The study included measurement of the levels of homocysteine (HC), total cholesterol, cholesterol of low-density lipoproteins, cholesterol of high-density lipoproteins, and lipidperoxidation (LP) products (TBA-reactive products), as well as coagulo-fibrinolytic parameters. The study revealed that patients with instable angina had significantly higher levels of HC and TBA-reactive products compared to those with stable angina and healthy controls...
2005: Klinicheskaia Meditsina
Takahisa Ushiroyama, Sakura Nosaka, Minoru Ueki
The short-term and small-dose pleiotropic effects of atorvastatin and influence on sex steroid production were investigated in 35 premenopausal and 71 postmenopausal hypercholesterolemic, hypertriglyceridemic women, as well as the temporal differences in these pleiotropic effects. Atorvastatin (10 mg daily) was given for 6 months and fasting lipid concentrations, high sensitive CRP, and coagulo-fibrinolytic parameters were measured at baseline and after 3 and 6 months of therapy. Atorvastatin reduced the low-density lipoprotein cholesterol, remnant-like particle lipoprotein cholesterol, and malondialdehyde-modified low-density lipoprotein cholesterol after 3 and 6 months in both pre- and postmenopausal women...
October 26, 2006: International Journal of Cardiology
Tsutomo Fujii, Akimasa Nakao
In acute pancreatitis, coagulo-fibrinolytic abnormalities may easily result in disseminated intravascular coagulation (DIC). The prognosis will become very poor, once bleeding necrosis or circulatory failure also occur in important internal organs other than the pancreas, leading to multiple organ failure. Changes in blood coagulation and fibrinolysis system may be greatly involved in the severity of acute pancreatitis. In medical treatment, it is necessary to be cautious of predictors of severity, and to perform the early diagnosis of DIC along with quick and positive intensive management...
November 2004: Nihon Rinsho. Japanese Journal of Clinical Medicine
A Suehiro, T Imagawa, H Hosokawa, M Suehiro, Y Ohe, E Kakishita
We recently reported that the serum level of macrophage colony-stimulating factor (M-CSF) was elevated in patients with cerebral infarction. In the present study, we measured serum M-CSF level, as well as coagulo-fibrinolytic markers and general laboratory tests in adult healthy subjects of various ages, and investigated the relationship between age and M-CSF level. M-CSF in aged subjects (>or=65 years of age) was significantly higher than that in the younger subjects (<65 years of age), and a significant positive correlation between age and M-CSF was found...
July 1999: Archives of Gerontology and Geriatrics
No abstract text is available yet for this article.
December 15, 1960: Bollettino Della Società Italiana di Biologia Sperimentale
Z Zdrojewski, S Lizakowski, A Raszeja-Specht, A Skibowska, B Rutkowski
UNLABELLED: Platelet secretion products may play an important role in the pathogenesis and progression of the kidney disease. Amongst the parameters describing platelet hyperactivity the measurement of spontaneous platelet aggregation (SPA) seems particularly useful. In this study SPA as well as mean platelet volume (MPV), modal platelet volume (PLT Mode) and platelet count (PLT) were investigated in 60 patients with biopsy proven primary glomerulonephritis. SPA was measured using the turbidimetric method according to Born with no enhancers added...
September 2002: Nephron
Shi De Lin, Ryujin Endo, Akihiro Sato, Yasuhiro Takikawa, Kamon Shirakawa, Kazuyuki Suzuki
BACKGROUND AND AIM: Urinary trypsin inhibitor (UTI) is synthesized by hepatocytes and excreted into urine. Plasma and urine UTI levels have been measured to evaluate whether these levels may be useful markers in various pathological conditions. However, there has been no study on plasma and urine UTI levels in patients with acute liver diseases. The aim of the present study was to evaluate plasma and urine UTI levels and their relationship with the severity of hepatic damage in patients with acute liver diseases...
February 2002: Journal of Gastroenterology and Hepatology
K Nozaki, A Endou, K Sakurai, O Takahata, H Iwasaki
A laryngeal mask airway (LMA) and epidural analgesia were used for anesthetic management of microwave coagulo-necrotic therapy for multiple hepatoma in a 76-year-old male with a giant bulla and liver cirrhosis. Since bleeding times, PT and APTT were within normal limits, an epidural catheter was inserted between Th9 and 10 interspaces in operating room. After preoxygenation, general anesthesia was induced with propofol 120 mg. After insertion of a LMA, anesthesia was maintained under spontaneous breathing with sevoflurane (1-1...
June 2001: Masui. the Japanese Journal of Anesthesiology
N Eriguchi, S Aoyagi, K Okuda, T Tamae, S Fukuda, N Kanazawa, S Hamada, M Kawabata, K Nishimura, T Kodama
We report here two patients with hepatocellular carcinoma who experienced implanted metastases in the abdominal cavity after hepatectomy or microwave coagulo-necrotic therapy. Hepatic resection and microwave coagulo-necrotic therapy were successful for these tumors, and the postoperative status was satisfactory in both patients. Implanted metastases were discovered in the abdominal cavity of each of these two patients 6 months after surgery. It is necessary to look not only for the presence of liver metastasis but also for the recurrence of the tumor in the abdominal cavity during the follow-up period...
2000: Journal of Hepato-biliary-pancreatic Surgery
H Ohteki, K Furukawa, H Ohnishi, Y Narita, M Sakai, K Doi
PURPOSE: We have reviewed our experience with Argatroban-a direct thrombin inhibitor for anticoagulation--in a variety of cardiovascular operations, and in extracorporeal circulation, as a substitute for heparin. SUBJECTS AND METHODS: 60 patients receiving anticoagulation with Argatroban were classified into the following four groups. Group 1; 20 patients with anticoagulation therapy after cardiac surgery. Group 2; 8 patients with extracorporeal circulation for continuous hemofiltration for either pre- or post-operative control of acute renal failure...
January 2000: Japanese Journal of Thoracic and Cardiovascular Surgery
M Aramaki, K Kawano, T Kai, H Yokoyama, Y Morii, A Sasaki, T Yoshida, S Kitano
BACKGROUND/AIMS: Recent advances in both the diagnosis and treatment of hepatocellular carcinoma (HCC) have improved its prognosis. Intrahepatic recurrence after hepatectomy can be treated with repeated hepatectomy, transhepatic arterial embolization (TAE), percutaneous ethanol injection therapy (PEIT), or microwave coagulo-necrotic therapy. However, treatment for extrahepatic recurrence is also important in prolonging survival in some patients. METHODOLOGY: After radical hepatectomy in 155 patients, extrahepatic recurrences were found in 15 patients that underwent subsequent treatment...
September 1999: Hepato-gastroenterology
S Otsuka
Recently, microwave coagulation has been in the spotlight for its local application on tumor necrosis with sufficient effects. We introduce here percutaneous microwave coagulation therapy (PMCT) and endoscopic microwave coagulo-necrotic therapy (endo. MCN) for small hepatocellular carcinoma.
May 1996: Nihon Rinsho. Japanese Journal of Clinical Medicine
J Malyszko, J S Malyszko, K Pawlak, M Mysliwiec
Since thromboembolic complications in transplanted patients are generally attributed to combined abnormalities in platelets and coagulo-lytic system, some hemostatic parameters tPA (tissue plasmogin activator):Ag and activity, its inhibitor-PAIAg and activity, tPA/PAI, thrombin-antithrombin (TAT) and plasmin-antiplasmin complexes (PAP), urokinase-uPA, euglobulin clot lysis time-ECLT, fibrinogen, plasminogen, protein C activity, D-dimer, prothrombin fragments1+2 (F1+2), fibrin monomers, fibronectin, lipoprotein-a, and von Willebrand factor(vWF), were evaluated using commercially available kits...
September 27, 1996: Transplantation
H Saitsu, T Nakayama
We performed microwave coagulo-necrotic therapy (MCN), a new surgical treatment for hepatocellular carcinoma (HCC) under laparotomy on 41 cases and under laparoscopy on 5 cases for a total of 46 cases (70 cancer nodules). The indications for MCN include: 1) cases in which an early recurrence is judged as likely to occur. For example, multinodular cases, or intrahepatic metastasis (im1-3) 25 cases (54.3%), 9 cases (19.6%) in which multiple adenomatous hyperplasia was detected, VP2 1 case (2.2%). 2) 7 cases (15...
April 1993: Nihon Rinsho. Japanese Journal of Clinical Medicine
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