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https://www.readbyqxmd.com/read/29894209/childhood-respiratory-risk-factor-profiles-their-interactions-and-mediators-and-middle-age-lung-function-a-prospective-cohort-study-from-the-1st-to-6th-decade
#1
Dinh S Bui, Haydn E Walters, John A Burgess, Jennifer L Perret, Minh Q Bui, Gayan Bowatte, Adrian J Lowe, Melissa A Russell, Bruce R Thompson, Garun S Hamilton, Alan L James, Graham G Giles, Paul S Thomas, Debbie Jarvis, Cecilie Svanes, Judith Garcia-Aymerich, Bircan Erbas, Peter A Frith, Katrina J Allen, Michael J Abramson, Caroline J Lodge, Shyamali C Dharmage
RATIONALE: Childhood risk factors for long-term lung health often co-exist and their specific patterns may affect subsequent lung function differently. OBJECTIVES: To identify childhood risk factor profiles, their influence on lung function and chronic obstructive pulmonary disease (COPD) in middle-age and potential pathways. METHODS: Profiles of 11 childhood respiratory risk factors, documented at age 7, were identified in 8352 participants from the Tasmanian Longitudinal Health Study using latent class analysis...
June 12, 2018: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29880157/the-melbourne-epidemic-thunderstorm-asthma-event-2016-an-investigation-of-environmental-triggers-effect-on-health-services-and-patient-risk-factors
#2
Francis Thien, Paul J Beggs, Danny Csutoros, Jai Darvall, Mark Hew, Janet M Davies, Philip G Bardin, Tony Bannister, Sara Barnes, Rinaldo Bellomo, Timothy Byrne, Andrew Casamento, Matthew Conron, Anthony Cross, Ashley Crosswell, Jo A Douglass, Matthew Durie, John Dyett, Elizabeth Ebert, Bircan Erbas, Craig French, Ben Gelbart, Andrew Gillman, Nur-Shirin Harun, Alfredo Huete, Louis Irving, Dharshi Karalapillai, David Ku, Philippe Lachapelle, David Langton, Joy Lee, Clare Looker, Christopher MacIsaac, Joseph McCaffrey, Christine F McDonald, Forbes McGain, Edward Newbigin, Robyn O'Hehir, David Pilcher, Shivonne Prasad, Kanishka Rangamuwa, Laurence Ruane, Vineet Sarode, Jeremy D Silver, Anne Marie Southcott, Ashwin Subramaniam, Cenk Suphioglu, Nugroho Harry Susanto, Michael F Sutherland, Gopal Taori, Philip Taylor, Paul Torre, Joseph Vetro, Geoffrey Wigmore, Alan C Young, Charles Guest
BACKGROUND: A multidisciplinary collaboration investigated the world's largest, most catastrophic epidemic thunderstorm asthma event that took place in Melbourne, Australia, on Nov 21, 2016, to inform mechanisms and preventive strategies. METHODS: Meteorological and airborne pollen data, satellite-derived vegetation index, ambulance callouts, emergency department presentations, and data on hospital admissions for Nov 21, 2016, as well as leading up to and following the event were collected between Nov 21, 2016, and March 31, 2017, and analysed...
June 2018: Lancet. Planetary Health
https://www.readbyqxmd.com/read/29797174/cytotoxicity-of-doxrubicin-loaded-single-walled-carbon-nanotubes
#3
Ayhan Ünlü, Mehdi Meran, Bircan Dinc, Nilgün Karatepe, Muhammet Bektaş, F Seniha Güner
Carbon nanotube (CNTs) is a new alternative for efficient drug delivery and it has a great potential to change drug delivery system profile in pharmaceutical industry. One of the important advantage of CNTs is their needle-like, cylindrical shape. This shape provides a high surface area for multiple connections and adsorption onto for millions of therapeutic molecules. CNTs can be internalized by cells via endocytosis, passive diffusion and phagocytosis and release the drug with different effects like pH and temperature...
May 24, 2018: Molecular Biology Reports
https://www.readbyqxmd.com/read/29625387/urinary-phthalate-metabolite-concentrations-in-girls-with-premature-thelarche
#4
Erdem Durmaz, Pinar Erkekoglu, Ali Asci, Sema Akçurin, İffet Bircan, Belma Kocer-Gumusel
In girls, breast development before eight years of age is called "premature thelarche (PT)". There are few studies in literature that show the interaction between PT and phthalate exposure. The aim of this study was to determine the urinary levels of di-(2-ethylhexyl) phthalate (DEHP) metabolites and other phthalate metabolites in girls with PT. PT group consisted of 29 newly diagnosed subjects. Control group comprised of healthy age-matched girls (n = 25). Urinary phthalate metabolite concentrations were measured by liquid chromatography/tandem mass spectroscopy (LC-MS/MS)...
April 2018: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/29616956/a-clinical-trial-on-the-efficacy-of-a-mediterranean-diet-enriched-with-fatty-fish-in-the-management-of-paediatric-asthma-preliminary-results
#5
Maria Papamichael, Charis Katsardis, Dimitrios Tsoukalas, Bircan Erbas, Catherine Itsiopoulos
No abstract text is available yet for this article.
April 2018: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/29579655/dynamic-ecological-observations-from-satellites-inform-aerobiology-of-allergenic-grass-pollen
#6
Rakhesh Devadas, Alfredo R Huete, Don Vicendese, Bircan Erbas, Paul J Beggs, Danielle Medek, Simon G Haberle, Rewi M Newnham, Fay H Johnston, Alison K Jaggard, Bradley Campbell, Pamela K Burton, Constance H Katelaris, Ed Newbigin, Michel Thibaudon, Janet M Davies
Allergic diseases, including respiratory conditions of allergic rhinitis (hay fever) and asthma, affect up to 500 million people worldwide. Grass pollen are one major source of aeroallergens globally. Pollen forecast methods are generally site-based and rely on empirical meteorological relationships and/or the use of labour-intensive pollen collection traps that are restricted to sparse sampling locations. The spatial and temporal dynamics of the grass pollen sources themselves, however, have received less attention...
August 15, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29524247/the-role-of-fish-intake-on-asthma-in-children-a-meta-analysis-of-observational-studies
#7
REVIEW
Maria Michelle Papamichael, Som Kumar Shrestha, Catherine Itsiopoulos, Bircan Erbas
BACKGROUND: The evidence is mixed on the use of long chain omega 3 fatty acids in the prevention and management of childhood asthma. METHODS: We conducted a systematic search and meta-analysis investigating the role of fish intake, the main dietary source of long chain omega-3 fatty acids, on asthma in children. RESULTS: A total of 1,119 publications were identified. Twenty-three studies on fish intake in association with childhood asthma were included in the final review...
March 9, 2018: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29522998/critical-age-windows-in-the-impact-of-lifetime-smoking-exposure-on-respiratory-symptoms-and-disease-among-ever-smokers
#8
Bircan Erbas, Toril Mørkve Knudsen, Christer Janson, Roy M Nilsen, Simone Accordini, Bryndis Benediktdottir, Julia Dratva, Joachim Heinrich, Debbie Jarvis, Benedcite Leynaert, Melanie C Matheson, Dan Norbäck, Francisco G Real, Chantal Raherison-Semjen, Simona Villani, S C Dharmage, C Svanes
BACKGROUND: Despite extensive knowledge of smoking effects on respiratory disease, there is no study including all age windows of exposure among ever smokers. The objective of this study was to assess the effects from smoking exposure in utero, early childhood, adolescence and adulthood on respiratory health outcomes in adult male and female ever smokers. METHODS: Respiratory health outcomes were assessed in 10,610 participants of the European Community Respiratory Health Survey (ECRHS) I who reported a history of ever smoking by questionnaire...
July 2018: Environmental Research
https://www.readbyqxmd.com/read/29427878/traffic-related-air-pollution-and-development-and-persistence-of-asthma-and-low-lung-function
#9
Gayan Bowatte, Caroline J Lodge, Luke D Knibbs, Bircan Erbas, Jennifer L Perret, Bin Jalaludin, Geoffrey G Morgan, Dinh S Bui, Graham G Giles, Garun S Hamilton, Richard Wood-Baker, Paul Thomas, Bruce R Thompson, Melanie C Matheson, Michael J Abramson, E Haydn Walters, Shyamali C Dharmage
BACKGROUND AND AIMS: Traffic Related Air Pollution (TRAP) exposure is known to exacerbate existing respiratory diseases. We investigated longer term effects of TRAP exposure for individuals with or without existing asthma, and with or without lower lung function. METHODS: Associations between TRAP exposure and asthma (n = 689) and lung function (n = 599) were investigated in the prospective Tasmanian Longitudinal Health Study (TAHS). TRAP exposure at age 45 years was measured using two methods based on residential address: mean annual NO2 exposure; and distance to nearest major road...
April 2018: Environment International
https://www.readbyqxmd.com/read/29405766/urinary-bisphenol-a-levels-in-turkish-girls-with-premature-thelarche
#10
E Durmaz, A Asci, P Erkekoglu, A Balcı, I Bircan, B Koçer-Gumusel
There is a growing concern over the timing of pubertal breast development and its possible association with exposure to endocrine disrupting chemicals (EDCs), such as bisphenol A (BPA). BPA is abundantly used to harden plastics. The aim of this study was to investigate the relation between premature thelarche (PT) and BPA by comparing the urinary BPA levels of PT girls with those of healthy subjects. Twenty-five newly diagnosed nonobese PT subjects (aged 4-8 years) who were admitted to the Pediatric Endocrinology Department at Akdeniz University were recruited...
January 1, 2018: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/29405729/the-effects-of-resveratrol-on-hepatic-oxidative-stress-in-metabolic-syndrome-model-induced-by-high-fructose-diet
#11
C Yilmaz Demirtas, F S Bircan, O T Pasaoglu, N Turkozkan
BACKGROUND: The purpose of this study was to evaluate probable protective effects of resveratrol treatment on hepatic oxidative events in a rat model of metabolic syndrome (MetS). METHODS: Thirty-two male adult rats were randomly divided into 4 groups: control, fructose, resveratrol, and fructose plus resveratrol. To induce MetS, fructose solution (20 % in drinking water) was used. Resveratrol (10 mg/kg/day) was given by oral gavage. All treatments were given for 8 weeks...
2018: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/29353264/response-to-growth-hormone-treatment-in-very-young-patients-with-growth-hormone-deficiencies-and-mini-puberty
#12
Semra Çetinkaya, Şükran Poyrazoğlu, Firdevs Baş, Oya Ercan, Metin Yıldız, Erdal Adal, Abdullah Bereket, Saygın Abalı, Zehra Aycan, Şenay Savaş Erdeve, Merih Berberoğlu, Zeynep Şıklar, Meltem Tayfun, Şükran Darcan, Eda Mengen, İffet Bircan, Filiz Mine Çizmecioğlu Jones, Enver Şimşek, Esra Deniz Papatya, Mehmet Nuri Özbek, Semih Bolu, Ayhan Abacı, Muammer Büyükinan, Feyza Darendeliler
BACKGROUND: The aim of the study was to assess the response to growth hormone (GH) treatment in very young patients with GH deficiency (GHD) through a national, multi-center study. Possible factors affecting growth response were assessed (especially mini-puberty). METHODS: Medical reports of GHD patients in whom treatment was initiated between 0 and 3 years of age were retrospectively evaluated. RESULTS: The cohort numbered 67. The diagnosis age was 12...
January 26, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/29331087/outdoor-pollen-is-a-trigger-of-child-and-adolescent-asthma-emergency-department-presentations-a-systematic-review-and-meta-analysis
#13
REVIEW
B Erbas, M Jazayeri, K A Lambert, C H Katelaris, L A Prendergast, R Tham, M J Parrodi, J Davies, E Newbigin, M J Abramson, S C Dharmage
BACKGROUND: In the context of increased asthma exacerbations associated with climatic changes such as thunderstorm asthma, interest in establishing the link between pollen exposure and asthma hospital admissions has intensified. Here, we systematically reviewed and performed a meta-analysis of studies on pollen and emergency department (ED) attendance. METHODS: A search for studies with appropriate search strategy in MEDLINE, EMBASE, Web of Science and CINAHL was conducted...
January 13, 2018: Allergy
https://www.readbyqxmd.com/read/29295917/graphene-based-bimorphs-for-micron-sized-autonomous-origami-machines
#14
Marc Z Miskin, Kyle J Dorsey, Baris Bircan, Yimo Han, David A Muller, Paul L McEuen, Itai Cohen
Origami-inspired fabrication presents an attractive platform for miniaturizing machines: thinner layers of folding material lead to smaller devices, provided that key functional aspects, such as conductivity, stiffness, and flexibility, are persevered. Here, we show origami fabrication at its ultimate limit by using 2D atomic membranes as a folding material. As a prototype, we bond graphene sheets to nanometer-thick layers of glass to make ultrathin bimorph actuators that bend to micrometer radii of curvature in response to small strain differentials...
January 16, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29248387/the-prevalence-of-food-sensitization-appears-not-to-have-changed-between-2-melbourne-cohorts-of-high-risk-infants-recruited-15-years-apart
#15
Rachel L Peters, Jennifer J Koplin, Katrina J Allen, Adrian J Lowe, Caroline J Lodge, Mimi L K Tang, Melissa Wake, Anne-Louise Ponsonby, Bircan Erbas, Michael J Abramson, David Hill, Lyle C Gurrin, Shyamali C Dharmage
BACKGROUND: Although food allergy has probably risen over recent decades, recent reports suggest that the prevalence of food sensitization in the general population has not changed. However, this has not been analyzed in infants at high risk of food allergy. OBJECTIVE: The objective of this study was to compare the prevalence of food sensitization in high-risk infants from 2 cohorts recruited 15 years apart in the same region. METHODS: This study includes 620 high-risk infants with a family history of allergy (Melbourne Atopy Cohort Study [MACS]) born 1990-1994, and a subgroup of high-risk infants from the population-based HealthNuts study (n = 3,661/5,276), born 2006-2010...
March 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29074540/traffic-related-air-pollution-exposure-over-a-5-year-period-is-associated-with-increased-risk-of-asthma-and-poor-lung-function-in-middle-age
#16
Gayan Bowatte, Bircan Erbas, Caroline J Lodge, Luke D Knibbs, Lyle C Gurrin, Guy B Marks, Paul S Thomas, David P Johns, Graham G Giles, Jennie Hui, Martine Dennekamp, Jennifer L Perret, Michael J Abramson, E Haydn Walters, Melanie C Matheson, Shyamali C Dharmage
Current evidence concerning the impact of exposure to traffic-related air pollution (TRAP) on adult respiratory morbidity mainly comes from cross-sectional studies. We sought to establish more robust measures of this association and potential gene-environment interactions using longitudinal data from an established cohort study.Associations between measures of TRAP (nitrogen dioxide (NO2) and distance to major roads) and wheeze, asthma prevalence and lung function were investigated in participants of the Tasmanian Longitudinal Health Study at 45- and 50-year follow-ups...
October 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29020463/the-role-of-human-rhinovirus-hrv-species-on-asthma-exacerbation-severity-in-children-and-adolescents
#17
Katrina A Lambert, Luke A Prendergast, Shyamali C Dharmage, Mimi Tang, Molly O'Sullivan, Thomas Tran, Julian Druce, Philip Bardin, Michael J Abramson, Bircan Erbas
OBJECTIVE: It is recognized that human rhinovirus (HRV) infection is an important factor in asthma exacerbations requiring hospitalization in children. However, previous studies have disagreed on the differential impact of various HRV species. We sought to assess the impact of HRV species on the severity of asthma exacerbations in children and adolescents. We also examined whether the effect of HRV species on severity was modified by age and gender. METHODS: Virus strain was determined for 113 children with HRV detectable at the time of admission for asthma exacerbation...
October 11, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28899934/bronchial-hyperresponsiveness-and-obesity-in-middle-age-insights-from-an-australian-cohort
#18
John A Burgess, Melanie C Matheson, Fei Diao, David P Johns, Bircan Erbas, Adrian J Lowe, Lyle C Gurrin, Caroline J Lodge, Paul S Thomas, Stephen Morrison, Bruce R Thompson, Iain Feather, Jennifer L Perret, Michael J Abramson, Graham G Giles, John L Hopper, Shyamali C Dharmage, Eugene H Walters
The association between obesity and bronchial hyperresponsiveness (BHR) is incompletely characterised. Using the 2006 follow-up of the Tasmanian Longitudinal Health Study, we measured the association between obesity and BHR and whether it was mediated by small airway closure or modified by asthma and sex of the patient.A methacholine challenge measured BHR. Multivariable logistic regression measured associations between body mass index (BMI) and BHR, adjusting for sex, asthma, smoking, corticosteroid use, family history and lung function...
September 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28890656/effects-of-teaching-health-care-workers-on-diagnosis-and-treatment-of-pesticide-poisonings-in-uganda
#19
REVIEW
Claudia Sibani, Kristian Kjaer Jessen, Bircan Tekin, Victoria Nabankema, Erik Jørs
BACKGROUND: Acute pesticide poisoning in developing countries is a considerable problem, requiring diagnosis and treatment. This study describes how training of health care workers in Uganda affects their ability to diagnose and manage acute pesticide poisoning. METHOD: A postintervention cross-sectional study was conducted using a standardized questionnaire. A total of 326 health care workers in Uganda were interviewed on knowledge and handling of acute pesticide poisoning...
2017: Environmental Health Insights
https://www.readbyqxmd.com/read/28886703/factors-associated-with-foot-ulceration-and-amputation-in-adults-on-dialysis-a-cross-sectional-observational-study
#20
Michelle R Kaminski, Anita Raspovic, Lawrence P McMahon, Katrina A Lambert, Bircan Erbas, Peter F Mount, Peter G Kerr, Karl B Landorf
BACKGROUND: Adults on dialysis are at increased risk of foot ulceration, which commonly precedes more serious lower limb complications, including amputation. Limited data exist regarding the prevalence and factors associated with foot disease in this population. Hence, this study set out to investigate factors associated with foot ulceration and amputation in a dialysis cohort. METHODS: This study presents a cross-sectional analysis of baseline data from a multi-center prospective cohort study...
September 8, 2017: BMC Nephrology
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