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JOURNAL ARTICLE
Elif Bircan Muyanlı, Remziye Yılmaz
BACKGROUND: Yeast biosynthesizes fusel alcohols in fermentation through amino acid catabolism via the Ehrlich pathway. ARO8 and ARO9 genes are involved in the first step of the Ehrlich pathway, while ADH2 and ADH5 genes are involved in the last step. In this study, we describe RT-qPCR methods to determine the gene expression level of genes (ARO8, ARO9, ADH2, ADH5) found in Saccharomyces cerevisiae (Sc) and Metschnikowia pulcherrima (Mp) strains growth pasteurized white grape juice. METHODS AND RESULTS: We used RNA extraction and cDNA synthesis protocols...
April 20, 2024: Molecular Biology Reports
#2
JOURNAL ARTICLE
Fatma Eser, İmran Hasanoğlu, Bircan Kayaaslan, Ayşe Kaya Kalem, Şule Bilen, Gürdal Orhan, Rahmet Güner
INTRODUCTION: Iatrogenic botulism is a rare, serious disease that progresses with descending paralysis and develops after cosmetic or therapeutic botulinum toxin-A (BoNT-A) application. CASE PRESENTATIONS: In this case series; six cases of iatrogenic botulism followed up in our center are presented. Four of these developed after gastric BoNT-A and two after axillary BoNT-A application. RESULTS: The most important cause for the disease was the use of unlicensed products and high-dose toxin applications...
March 31, 2024: Journal of Infection in Developing Countries
#3
JOURNAL ARTICLE
Hadi Karimkhani, Paria Shojaolsadati, Türkan Yiğitbaşı, Bircan Kolbası, Neslin Emekli
This study aimed to investigate the effects of the calpain inhibitor N-Acetyl-Leu-Leu-norleucinal (ALLN) on neuroapoptotic cell damage caused by Copper Oxide Nanoparticles (CuO-NP) and exacerbation of damage through brain ischemia/reperfusion (I/R) in a rat model. Male Wistar Albino rats (n=80) were divided into eight groups: Control, I/R, CuO-NP, CuO-NP+I/R, I/R+ALLN, CuO-NP+ALLN, CuO-NP+I/R+ALLN, and DMSO. Biochemical markers (MBP, S100B, NEFL, NSE, BCL-2, Cyt-C, Calpain, TNF-α, Caspase-3, MDA, and CAT) were measured in serum and brain tissue samples...
April 13, 2024: Biomedicine & Pharmacotherapy
#4
Niccolò Buetti, Alexis Tabah, Nour Setti, Stéphane Ruckly, François Barbier, Murat Akova, Abdullah Tarik Aslan, Marc Leone, Matteo Bassetti, Andrew Conway Morris, Kostoula Arvaniti, José-Artur Paiva, Ricard Ferrer, Haibo Qiu, Giorgia Montrucchio, Andrea Cortegiani, Bircan Kayaaslan, Liesbet De Bus, Jan J De Waele, Jean-François Timsit
No abstract text is available yet for this article.
April 8, 2024: Intensive Care Medicine
#5
Ethem Burak Oklaz, Ibrahim Kaya, Murat Ciceklidag, Resul Bircan, Muhammed Furkan Tosun, Ulunay Kanatli
INTRODUCTION: Abnormalities of the double-layered meniscus are rare and can be difficult to diagnose. The main pathology in this abnormality, which is predominantly seen in the lateral compartment, is an accessory meniscus lying over the normal meniscus. Anatomically, this structure can appear in different forms. Although other meniscal abnormalities associated with a double-layered meniscus have been reported, this case presents a previously undescribed type in the literature. CASE REPORT: A 12-year-old girl presented to our clinic with complaints of knee locking and pain...
March 2024: Journal of Orthopaedic Case Reports
#6
JOURNAL ARTICLE
Tijen Acar, Claire Gallagher, Yasemin Gören, Bircan Erbas, Adem Özkara
The aim of this study was to identify the determinants of smoking cessation outcomes and reasons for relapse following smoking cessation treatment. Using a mixed-method design, 179 patients were recruited from the Smoking Cessation outpatient clinic of Ankara Numune Training and Research Hospital between May 2016 and May 2017. Quantitative data were collected via questionnaires or from patient files and qualitative data were obtained via 5 focus group interviews with 28 patients who relapsed to smoking following treatment...
March 7, 2024: International Journal of Environmental Research and Public Health
#7
JOURNAL ARTICLE
Dilek Asiltürk, Rahmet Güner, Ayşe Kaya Kalem, Işıl Özkoçak Tufan, İmran Hasanoğlu, Fatma Eser, Simten Malhan, Bircan Kayaaslan
OBJECTIVES: The aim of this study was to investigate the effects of the carbapenem-restricted antimicrobial stewardship program (ASP) on changes in the resistance profiles of infectious agents, the amount of antibiotics used, length of stay in the intensive care unit (ICU), mortality and costs. MATERIALS AND METHODS: The patients hospitalized in ICU between July 1, 2020 - May 1, 2021 were included the study. The study was divided in to two different periods, carbapenem not-restricted period (CNRP) and carbapenem restricted period (CRP)...
March 21, 2024: Journal of Hospital Infection
#8
JOURNAL ARTICLE
Niccolò Buetti, Alexis Tabah, Nour Setti, Stéphane Ruckly, François Barbier, Murat Akova, Abdullah Tarik Aslan, Marc Leone, Matteo Bassetti, Andrew Conway Morris, Kostoula Arvaniti, José-Artur Paiva, Ricard Ferrer, Haibo Qiu, Giorgia Montrucchio, Andrea Cortegiani, Bircan Kayaaslan, Liesbet De Bus, Jan J De Waele, Jean-François Timsit
PURPOSE: The primary objective of this study was to evaluate the associations between centre/country-based factors and two important process and outcome indicators in patients with hospital-acquired bloodstream infections (HABSI). METHODS: We used data on HABSI from the prospective EUROBACT-2 study to evaluate the associations between centre/country factors on a process or an outcome indicator: adequacy of antimicrobial therapy within the first 24 h or 28-day mortality, respectively...
March 18, 2024: Intensive Care Medicine
#9
JOURNAL ARTICLE
Fatma Bursalı, İlke Demirkaya, İlknur Babahan Bircan, Fatih Mehmet Şimşek
OBJECTIVE: A series of aromatic thiosemicarbazone-oxime [TP1 and TP2] derivatives and their Ni(II), Cu(II), and Co(II) complexes were synthesized, and their larvicidal activity was evaluated against Aedes aegypti and Aedes albopictus larvae. The efficacy of these substances to Aedes albopictus larvae has been demonstrated for the first time. METHODS: Laboratory colonized Aedes aegypti and Aedes albopictus larvae were subjected to larvicidal activity tests. Larval mortality rates at 24 and 48 hours were recorded and LC50 values were calculated...
March 5, 2024: Türkiye Parazitolojii Dergisi
#10
MULTICENTER STUDY
Dilşah Başkol Elik, Şafak Kaya, Sevil Alkan, Tuna Demirdal, Alper Sener, Selçuk Kaya, Özlem Güzel Tunçcan, Bircan Kayaaslan, Rahmet Güner, Fatma Eser, Hasip Kahraman, Serhat Birengel, Elif Mukime Sarıcaoğlu, Esma Eroğlu, Fatma Çölkesen, Erman Öztürk, Hande Berk Cam, Çiğdem Mermutluoğlu, Şafak Özer Balin, Gülden Sincan, Nilgün Altın, Uluhan Sili, Bedia Mutay Suntur, Tuğba Arslan Gülen, Burak Deveci, Rabin Saba, Şaban İncecik, Gülden Eser Karlıdağ, Elif Hakko, Damla Akdağ, Hüseyin Aytaç Erdem, Hilal Sipahi, Candan Çicek, Mehmet Sezai Taşbakan, Meltem Taşbakan, Hüsnü Pullukçu, Tansu Yamazhan, Bilgin Arda, Sercan Ulusoy, Oguz Resat Sipahi
This multicentre (22 centres in Turkey) retrospective cohort study aimed to assess the clinical outcomes of patients with neutropenic fever and SARS-CoV-2 positivity. Study period was 15 March 2020-15 August 2021. A total of 170 cases (58 female, aged 59 ± 15.5 years) that fulfilled the inclusion criteria were included in the study. One-month mortality rate (OMM) was 44.8%. The logistic regression analysis showed the following significant variables for the mentioned dependent variables: (i) achieving PCR negativity: receiving a maximum of 5 days of favipiravir (p = 0...
March 3, 2024: Scientific Reports
#11
COMMENT
Alessia Costa, Jerome Atutornu, Tuba Bircan, Daniela Boraschi, Sasha Henriques, Richard Milne, Lydia Okoibhole, Christine Patch, Anna Middleton
No abstract text is available yet for this article.
March 2024: American Journal of Bioethics: AJOB
#12
JOURNAL ARTICLE
Miray Kavuzlu, Bircan Zengel, Bilkay Baştürk
OBJECTIVES: HLA molecules play a crucial role in transplantation. The best treatment modality in patients with end-stage renal disease is renal transplant. HLA mismatches between patients and donors can prolong time for renal transplant therapy, reduce graft survival, and increase mortality. HLA region is the most polymorphic genetic region and is essential for antigen presentation. The main target of the recipient's immune system is HLA molecules on the surface of donor cells. HLA-B*51 is associated with Behcet disease, a rare multisystemic disease characterized by autoimmunity and inflammatory processes...
January 2024: Experimental and Clinical Transplantation
#13
JOURNAL ARTICLE
Meryem Ay Kesgin, Melike Saraç, Nils Grede, Alanur Çavlin Bircan, İsmet Koç
Despite the global decrease over the last two decades, stunting, also called 'chronic malnutrition', remains a public health issue affecting almost 150 million children under the age of 5 years globally. Defined by height-for-age, stunting is the consequence of poor nutrition, repeated infection, and inadequate psychosocial stimulation. Programmes and policies target undernutrition globally, and humanitarian and development actors invest great efforts to prevent stunting. This study uses multivariate analysis to examine the impact of financial assistance on the reduction of stunting in a refugee context, focusing on Syrian refugee children under the age of 5 years in Türkiye...
February 15, 2024: Journal of Biosocial Science
#14
REVIEW
Claire Gallagher, Mehak Batra, Sowmya Nagappa Malamardi, Bircan Erbas
Asthma is a global health concern affecting millions of children and adolescents. This review focuses on the possible factors that are associated with the transition from preschool wheezing to childhood asthma and highlights the significance of early-life environmental exposures during pregnancy and the first 6 months of life in shaping allergies and asthma. We observed a scarcity of studies investigating this subgroup, with most focusing on wheezing trajectories. We undertook a thorough investigation of diverse perinatal exposures that have the potential to impact this transition...
February 2024: Pediatric Allergy and Immunology
#15
JOURNAL ARTICLE
Melis Selamoglu, Bircan Erbas, Hester Wilson, Chris Barton
BACKGROUND: A significant policy change impacting the availability of nicotine for use in electronic cigarettes (e-cigarettes) in Australia took effect from October 1, 2021. This change meant that nicotine containing liquids for use with e-cigarettes would only be available by prescription from a medical practitioner as part of a smoking cessation plan. This study aimed to explore general practitioners (GPs) perceptions about the role of e-cigarettes, and understand factors informing their intentions to prescribe e-cigarettes as part of a smoking cessation plan...
February 7, 2024: BMC Prim Care
#16
JOURNAL ARTICLE
Müge Ayhan, Belgin Coşkun, Bircan Kayaaslan, İmran Hasanoğlu, Ayşe Kaya Kalem, Fatma Eser, Yeşim Aybar Bilir, Serpil Ünlü, Rahmet Güner
INTRODUCTION: The most important and undesirable consequence of inappropriate antibiotic use is the spread of antibiotic resistance, increased adverse effects, increased mortality and healthcare costs. We aimed to assess antibiotic usage characteristics in inpatient setting in our center. MATERIALS AND METHODS: A one-day, single center point-prevalence study was carried out on June 9th 2021, in Ankara City Hospital in Turkey. Data of antibiotic consumption, appropriateness of usage and predictors of inappropriate use in adult patients were evaluated...
2024: PloS One
#17
JOURNAL ARTICLE
Bircan Kahraman Berberoğlu, Hüsniye Çalişir
AIM: This study aims to assess how a structured supportive approach applied to the parents of children living with cerebral palsy according to how the Theory of Comfort affects the child's comfort, quality of life, and parent's self-efficacy. DESIGN: A single-blind, randomised, controlled experimental trial. METHODS: The study was conducted with parents of children with cerebral palsy aged between 8 and 16 years who presented to the rehabilitation centers between October 2021 and November 2022...
January 20, 2024: Journal of Pediatric Nursing
#18
JOURNAL ARTICLE
Daniel J Tan, Caroline J Lodge, E Haydn Walters, Dinh S Bui, Jonathan Pham, Adrian J Lowe, Gayan Bowatte, Don Vicendese, Bircan Erbas, David P Johns, Alan L James, Peter Frith, Garun S Hamilton, Paul S Thomas, Richard Wood-Baker, MeiLan K Han, George R Washko, Michael J Abramson, Jennifer L Perret, Shaymali C Dharmage
RATIONALE: The term 'pre-COPD' refers to individuals at high-risk of developing Chronic Obstructive Pulmonary Disease (COPD) who do not meet conventional spirometric criteria for airflow obstruction. New approaches to identifying these individuals are needed, particularly in younger populations. OBJECTIVE: To determine whether lung function thresholds and respiratory symptoms can be used to identify individuals at-risk of developing COPD. METHODS: The Tasmanian Longitudinal Health Study is a population-based cohort first studied in 1968 (age 7)...
January 18, 2024: American Journal of Respiratory and Critical Care Medicine
#19
JOURNAL ARTICLE
Güler Berkiten, Cem Çelik, Melis Koşar Tunç, Defne Gürbüz, Hasan Sami Bircan, Belgin Tutar, Ertan Berkiten, Yavuz Uyar
OBJECTIVE: This study investigates the importance of bone density, surface area, and diameter of anatomical structures of the superior semicircular canal (SSC), lateral semicircular canal (LSC), posterior semicircular canal (PSC), utricle, and saccule in patients diagnosed with superior semicircular canal dehiscence (SSCD). MATERIALS AND METHODS: The bone density, surface area, and diameter of SSC, LSC, PSC, utricle, and saccule were measured and compared between the SSCD group and control group...
January 2, 2024: European Archives of Oto-rhino-laryngology
#20
JOURNAL ARTICLE
Rossella Cannarella, Rupin Shah, Ramadan Saleh, Florence Boitrelle, Taha Abo-Almagd Abdel-Meguid Hamoda, Rajender Singh, Gianmaria Salvio, Tuncay Toprak, Marco Falcone, Murat Gul, Fotios Dimitriadis, Amarnath Rambhatla, Giorgio I Russo, Edmund Ko, Armand Zini, Parviz Kavoussi, Nguyen Ho Vinh Phuoc, Hussein Kandil, Ramy Abou Ghayda, Ponco Birowo, Nazim Gherabi, Erman Ceyhan, Jie Dong, Vineet Malhotra, Damayanthi Durairajanayagam, Bircan Kolbasi, Fahmi Bahar, Gokhan Calik, Selahittin Çayan, Germar-Michael Pinggera, Aldo E Calogero, Osvaldo Rajmil, Taymour Mostafa, Widi Atmoko, Ahmed M Harraz, Tan V Le, Jean de la Rosette, Lukman Hakim, Edoardo Pescatori, Oleg Sergeyev, Ayman Rashed, Pallavi Saini, Ashok Agarwal
PURPOSE: Varicoceles can be a source of elevated seminal oxidative stress (OS) and sperm DNA fragmentation (SDF). However, it remains unclear whether varicocele repair (VR) could reduce these parameters. This systematic review and meta-analysis (SRMA) aims to investigate the impact of VR on SDF and seminal malondialdehyde (MDA). MATERIALS AND METHODS: A literature search was performed in Scopus, PubMed, Ovid, Embase, and Cochrane databases. This SRMA included randomized controlled trials and observational studies reporting the pre- and postoperative levels of SDF and seminal OS in infertile men with clinical varicocele that underwent VR...
January 2, 2024: World Journal of Men's Health
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