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https://www.readbyqxmd.com/read/27917752/genetic-and-environmental-factors-in-invasive-cervical-cancer-design-and-methods-of-a-classical-twin-study
#1
Dorothy A Machalek, John D Wark, Sepehr N Tabrizi, John L Hopper, Minh Bui, Gillian S Dite, Alyssa M Cornall, Marian Pitts, Dorota Gertig, Bircan Erbas, Suzanne M Garland
BACKGROUND: Persistent high-risk human papillomavirus (HPV) infection is a necessary prerequisite for development of cervical cancer and its precursor lesion, high-grade squamous intraepithelial lesion (HSIL). However, HPV infection is not sufficient to drive this process, and genetic and environmental factors may also play a role. METHODS/DESIGN: The Cervical Cancer, Genetics and Environment Twin Study was established to investigate the environmental and genetic influences on variation in susceptibility to cervical pre-cancer in 25- to 69-year-old monozygotic (MZ) and dizygotic (DZ) twins recruited through the Australian Twin Registry...
December 5, 2016: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://www.readbyqxmd.com/read/27876713/role-of-acoustic-radiation-force-impulse-arfi-elastography-in-determination-of-severity-of-benign-prostate-hyperplasia
#2
Bircan Alan, Mazhar Utangaç, Cemil Göya, Mansur Dağgülli
BACKGROUND The aim of this study was to investigate the potential contribution of acoustic radiation force impulse (ARFI) elastography to the determination of the severity of benign prostate hypertrophy (BPH) by performing shear wave velocity (SWV) measurements of the prostate using ARFI technology. MATERIAL AND METHODS Sixty BPH patients and 40 healthy volunteers were included in this study. SWV measurements of the prostate were performed by transabdominal ultrasonography (US), both in the BPH patients and control subjects...
November 23, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27863158/hallux-valgus-by-nature-or-nurture-a-twin-study
#3
Shannon E Munteanu, Hylton B Menz, John D Wark, Jemma J Christie, Katrina J Scurrah, Minh Bui, Bircan Erbas, John L Hopper, Anita E Wluka
OBJECTIVE: To evaluate the contributions of shared but unmeasured genetic and environmental factors to hallux valgus (HV). METHODS: Between 2011-2012, 74 monozygotic (MZ) and 56 dizygotic (DZ) female twin pairs self-reported HV and putative risk factors, including footwear use across their lifespan. Estimates of casewise concordance (PC ), correlation (ρ) and odds ratios (OR) were calculated, adjusting for age and other risk factors, and compared between MZ and DZ pairs using logistic regression, generalised estimating equations and a maximum likelihood-based method, respectively...
November 18, 2016: Arthritis Care & Research
https://www.readbyqxmd.com/read/27805512/the-most-common-hla-alleles-and-anti-hla-antibodies-to-know-for-virtual-cross-match
#4
Bilkay Baştürk, Bircan Kantaroğlu, Miray Kavuzlu, Çağla Sarıtürk
OBJECTIVES: Human leukocyte antigens and HLAspecific antibodies are important before and after transplant treatment. The determination of the alloantibodies before transplant is useful for the estimation of risk for antibody-mediated rejection. Virtual crossmatch uses solid-phase assay to detect anti-HLA antibodies and allows exclusion of donors with unacceptable HLA antigens. The aim of our retrospective study was to investigate HLA class I and class II alleles and panel reactive antibody and Luminex Corporation (Austin, TX, USA) single-antigen bead assay positivity frequencies in the Southeastern region of Turkey...
November 2016: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/27803754/the-diagnostic-significance-of-signal-peptide-complement-c1r-c1s-uegf-and-bmp1-epidermal-growth-factor-domain-containing-protein-1-levels-in-pulmonary-embolism
#5
Nigar Dirican, Ali Duman, Gülcan Sağlam, Akif Arslan, Onder Ozturk, Sule Atalay, Ahmet Bircan, Ahmet Akkaya, Munire Cakir
BACKGROUND: Pulmonary embolism (PE) is a common and potentially life-threatening disorder. Patients with PE often have nonspecific symptoms, and the diagnosis is often delayed. AIM: The aim of our study was to investigate the role of signal peptide-complement C1r/C1s, Uegf, and Bmp1-epidermal growth factor domain-containing protein 1 (SCUBE1) used in the diagnosis of PE. METHODS: The study was designed prospectively. A total of 57 patients who were admitted to emergency service with clinically suspected PE were included in the study...
October 2016: Annals of Thoracic Medicine
https://www.readbyqxmd.com/read/27787642/differential-diagnosis-of-idiopathic-granulomatous-mastitis-and-breast-cancer-using-acoustic-radiation-force-impulse-imaging
#6
Memik Teke, Fatma Teke, Bircan Alan, Ahmet Türkoğlu, Cihad Hamidi, Cemil Göya, Salih Hattapoğlu, Metehan Gumus
PURPOSE: Differentiation of idiopathic granulomatous mastitis (IGM) from carcinoma with routine imaging methods, such as ultrasonography (US) and mammography, is difficult. Therefore, we evaluated the value of a newly developed noninvasive technique called acoustic radiation force impulse imaging in differentiating IGM versus malignant lesions in the breast. METHODS: Four hundred and eighty-six patients, who were referred to us with a presumptive diagnosis of a mass, underwent Virtual Touch tissue imaging (VTI; Siemens) and Virtual Touch tissue quantification (VTQ; Siemens) after conventional gray-scale US...
October 27, 2016: Journal of Medical Ultrasonics
https://www.readbyqxmd.com/read/27690697/antioxidant-effect-of-ukrain-versus-n-acetylcysteine-against-acute-biliary-pancreatitis-in-an-experimental-rat-model
#7
Sezgin Zeren, Zulfu Bayhan, Cengiz Koçak, Fatma Emel Koçak, Mehmet Huseyin Metineren, Bircan Savran, Havva Kocak, Mustafa Cem Algin, Cuneyt Kahraman, Ahmet Kocak, Suleyman Cosgun
: Purpose/Aim: Oxidative stress plays an important role in the pathogenesis of acute pancreatitis (AP). We compared the therapeutic effects of Ukrain (NSC 631570) and N-acetylcysteine (NAC) in rats with AP. MATERIALS AND METHODS: Forty male Sprague Dawley rats were divided into four groups: controls; AP; AP with NAC; and AP with Ukrain. AP was induced via the ligation of the bile-pancreatic duct; drugs were administered intraperitoneally (i.p.) 30 min and 12 h after AP induction...
October 3, 2016: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/27599029/case-reports-of-a-mother-and-daughter-diagnosed-with-persistent-genital-arousal-disorder
#8
Ejder Akgun Yildirim, Munevver Hacioglu Yıldırım, Ilker Kucukparlak, Irmak Bircan, Funda Cicek, Altan Essizoglu, Cagatay Karsidag, Murat Erkiran
No abstract text is available yet for this article.
September 6, 2016: Journal of Sex & Marital Therapy
https://www.readbyqxmd.com/read/27590890/is-there-a-march-from-early-food-sensitization-to-later-childhood-allergic-airway-disease-results-from-two-prospective-birth-cohort-studies
#9
Shatha A Alduraywish, Marie Standl, Caroline J Lodge, Michael J Abramson, Katrina J Allen, Bircan Erbas, Andrea von Berg, Joachim Heinrich, Adrian J Lowe, Shyamali C Dharmage
BACKGROUND: The march from early aeroallergen sensitization to subsequent respiratory allergy is well established, but it is unclear whether early life food sensitization precedes and further increases risk of allergic airway disease. OBJECTIVE: To assess the association between food sensitization in the first 2 years of life and subsequent asthma and allergic rhinitis by age 10-12 years. METHODS: We used data from two independent cohorts: the high-risk Melbourne Atopic Cohort Study (MACS) (n = 620) and the population-based LISAplus (n = 3094)...
September 3, 2016: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/27573796/evaluation-of-parathyroid-lesions-with-point-shear-wave-elastography
#10
Salih Hattapoğlu, Cemil Göya, Cihad Hamidi, Bekir Taşdemir, Bircan Alan, Mehmet Sedat Durmaz, Memik Teke, Faysal Ekici
OBJECTIVES: The aim of our study was to evaluate the shear wave velocity (SWV) of parathyroid lesions by point shear wave elastography (SWE) and to compare their stiffness with that of thyroid nodules and normal thyroid parenchyma quantitatively. METHODS: Thirty-six patients considered to have parathyroid disorders by clinical and laboratory tests and scintigraphy were enrolled in the study between January 2012 and February 2015. Conventional sonography, Doppler sonography, and the Virtual Touch tissue quantification (VTQ) method of point SWE (Siemens Medical Solutions, Mountain View, CA) were conducted with a linear transducer (4-9 MHz) while the patients were in the supine position...
October 2016: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/27567037/evaluation-of-postoperative-undescended-testicles-using-point-shear-wave-elastography-in-children
#11
Salih Hattapoğlu, Cemil Göya, Serkan Arslan, Bircan Alan, Faysal Ekici, Güven Tekbaş, İsmail Yıldız, Cihad Hamidi
PURPOSE: To demonstrate the difference in tissue stiffness by comparing the value of the shear wave velocity (SWV) of postoperative undescended testicles with that of normal testes. METHODS: This study included 39 patients and 30 healthy controls. US and p-SWE (VTQ) were performed using with a linear probe (4-9MHz). Forty-seven operated undescended testicles comprised "Group A", 27 testes with normal scrotal placement since birth in patient population comprised "Group B"...
December 2016: Ultrasonics
https://www.readbyqxmd.com/read/27525921/is-the-tshr-d727e-polymorphism-a-genetic-predisposition-for-multinodular-goiter-in-the-turkish-population
#12
H I Gözü, S Özçelik, M Aloğlu, A Şahin, S Temiz, A Dayan, H Cengiz, Y Tütüncü, R Bircan
The D727E germline polymorphism in the thyroid-stimulating hormone receptor gene (TSHR) may cause genetic susceptibility to the development of goiter. Therefore, in this study we investigated allele frequencies and genotype distributions of the TSHR D727E polymorphism, their association with clinical parameters, and the development of goiter in the Turkish population. We investigated the TSHR D727E polymorphism in 123 patients and 97 healthy subjects using the polymerase chain reaction-restriction fragment length polymorphism technique...
2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27523960/associations-between-outdoor-fungal-spores-and-childhood-and-adolescent-asthma-hospitalisations
#13
Rachel Tham, Don Vicendese, Shyamali Dharmage, Rob J Hyndman, Ed Newbigin, Emma Lewis, Molly O'Sullivan, Adrian J Lowe, Philip Taylor, Philip Bardin, Mimi L K Tang, Michael J Abramson, Bircan Erbas
BACKGROUND: Childhood asthma is a significant public health problem and severe exacerbations can result in diminished quality of life and hospitalisation. OBJECTIVE: To examine the contribution of outdoor fungi to childhood and adolescent asthma hospitalisations. METHODS: The Melbourne Air Pollen Children and Adolescent (MAPCAH) study is a case-crossover study of 644 children and adolescents (aged 2-17 years) hospitalised for asthma. MAPCAH collected individual data on human rhinovirus (HRV) infection and sensitisation to Alternaria and Cladosporium; and daily counts of ambient concentrations of fungal spores, pollen and air pollutants...
August 11, 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27513270/investigating-the-in-vitro-synergistic-activities-of-several-antibiotic-combinationsagainst-carbapenem-resistant-acinetobacter-baumannii-isolates
#14
Sevim Yavaş, Meltem Arzu Yetkin, Bircan Kayaaslan, Aliye Baştuğ, Halide Aslaner, Ayşe But, Dilek Kanyilmaz, Berrin Sari, Esragül Akinci, Hürrem Bodur
BACKGROUND/AIM: Acinetobacter baumannii (A. baumannii) is one of the most common healthcare-associated infectious agents worldwide. The aim of this study was to investigate the in vitro synergistic activities of several antibiotic combinations against carbapenem-resistant (CR) A. baumannii isolates. MATERIALS AND METHODS: Eighteen CR A. baumannii strains were isolated from the patients who were hospitalized in the intensive care unit between June 2012 and August 2012...
2016: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/27511493/does-the-course-of-laboratory-parameters-help-us-to-predict-the-outcome-of-cchf
#15
Sümeyye Kazancioğlu, Esragül Akinci, Aliye Baştuğ, Bircan Kayaaslan, Ayşe But, Halide Aslaner, Selim Sırrı Eren, Meltem Arzu Yetkin, Hurrem Bodur
BACKGROUND/AIM: This study was performed to identify the characteristics distinguishing fatal and nonfatal cases of patients diagnosed with Crimean-Congo hemorrhagic fever (CCHF). MATERIALS AND METHODS: A total of 92 patients with confirmed diagnosis of CCHF in 2009-2013 were included in the study. RESULTS: A high level of urea and aPTT on the third day of hospital stay, diarrhea, somnolence, and the interval from the beginning of the symptoms to hospital admission were independently associated with fatality...
February 17, 2016: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/27500488/recurrent-ezh1-mutations-are-a-second-hit-in-autonomous-thyroid-adenomas
#16
Davide Calebiro, Elisa S Grassi, Markus Eszlinger, Cristina L Ronchi, Amod Godbole, Kerstin Bathon, Fabiana Guizzardi, Tiziana de Filippis, Knut Krohn, Holger Jaeschke, Thomas Schwarzmayr, Rifat Bircan, Hulya Iliksu Gozu, Seda Sancak, Marek Niedziela, Tim M Strom, Martin Fassnacht, Luca Persani, Ralf Paschke
Autonomous thyroid adenomas (ATAs) are a frequent cause of hyperthyroidism. Mutations in the genes encoding the TSH receptor (TSHR) or the Gs protein α subunit (GNAS) are found in approximately 70% of ATAs. The involvement of other genes and the pathogenesis of the remaining cases are presently unknown. Here, we performed whole-exome sequencing in 19 ATAs that were paired with normal DNA samples and identified a recurrent hot-spot mutation (c.1712A>G; p.Gln571Arg) in the enhancer of zeste homolog 1 (EZH1) gene, which codes for a catalytic subunit of the polycomb complex...
September 1, 2016: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27468121/clinical-and-molecular-genetic-analysis-in-three-children-with-wolfram-syndrome-a-novel-wfs1-mutation-c-2534t-a
#17
Gamze Çelmeli, Doğa Türkkahraman, Yusuf Çürek, Jayne Houghton, Sema Akçurin, İffet Bircan
Wolfram syndrome (WS) is an autosomal recessive disorder caused by mutations in WFS1 gene. The main clinical features include diabetes insipidus (DI), diabetes mellitus (DM), optic atrophy (OA) and deafness (D) with other variable clinical manifestations. The aim of this paper is to present three cases of WS from three unrelated Turkish families with their clinical and genetic characteristics. The first two cases developed all symptoms of the disease in the first decade. Heterozygous father of the case two was symptomatic with bilateral deafness...
July 27, 2016: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/27452611/diagnosis-of-pre-eclampsia-and-assessment-of-severity-through-examination-of-the-placenta-with-acoustic-radiation-force-impulse-elastography
#18
Bircan Alan, Senem Tunç, Elif Agacayak, Aslan Bilici
OBJECTIVE: To assess the value of placental shear wave velocity (SWV) measurement by acoustic radiation force impulse (ARFI) imaging for the diagnosis of pre-eclampsia and to determine the relationship between the SWV and the severity of pre-eclampsia. METHODS: A prospective study was performed at a center in Turkey between August 2014 and March 2015. The study included consecutive pregnant women in the second or third trimester diagnosed with pre-eclampsia and healthy pregnant women without pre-eclampsia of similar ages...
October 2016: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/27390409/association-between-mean-platelet-volume-and-bone-mineral-density-in-postmenopausal-women
#19
Cenk Aypak, Özlem Türedi, Mustafa A Bircan, Gul M Civelek, Mine Araz
[Purpose] Osteoporosis is an inflammatory disease, and platelets play a critical role in bone remodeling. Mean platelet volume has been shown to be influenced by inflammation. Our aim was to evaluate the relationship between mean platelet volume and bone mineral density in postmenopausal women. [Subjects and Methods] The records of female patients who had been referred to a tertiary hospital for bone mineral density analysis were retrospectively reviewed. [Results] A total of 175 patients (mean age: 61.3 ± 9...
June 2016: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/27372567/traffic-related-air-pollution-exposure-is-associated-with-allergic-sensitization-asthma-and-poor-lung-function-in-middle-age
#20
Gayan Bowatte, Caroline J Lodge, Luke D Knibbs, Adrian J Lowe, Bircan Erbas, Martine Dennekamp, Guy B Marks, Graham Giles, Stephen Morrison, Bruce Thompson, Paul S Thomas, Jennie Hui, Jennifer L Perret, Michael J Abramson, Haydn Walters, Melanie C Matheson, Shyamali C Dharmage
BACKGROUND: Traffic-related air pollution (TRAP) exposure is associated with allergic airway diseases and reduced lung function in children, but evidence concerning adults, especially in low-pollution settings, is scarce and inconsistent. OBJECTIVES: We sought to determine whether exposure to TRAP in middle age is associated with allergic sensitization, current asthma, and reduced lung function in adults, and whether these associations are modified by variants in Glutathione S-Transferase genes...
May 24, 2016: Journal of Allergy and Clinical Immunology
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