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Sezgin Zeren, Zulfu Bayhan, Cengiz Koçak, Fatma Emel Koçak, Mehmet Huseyin Metineren, Bircan Savran, Havva Kocak, Mustafa Cem Algin, Cuneyt Kahraman, Ahmet Kocak, Suleyman Cosgun
: Purpose/Aim: Oxidative stress plays an important role in the pathogenesis of acute pancreatitis (AP). We compared the therapeutic effects of Ukrain (NSC 631570) and N-acetylcysteine (NAC) in rats with AP. MATERIALS AND METHODS: Forty male Sprague Dawley rats were divided into four groups: controls; AP; AP with NAC; and AP with Ukrain. AP was induced via the ligation of the bile-pancreatic duct; drugs were administered intraperitoneally (i.p.) 30 min and 12 h after AP induction...
October 3, 2016: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
Ejder Akgun Yildirim, Munevver Hacioglu Yıldırım, Ilker Kucukparlak, Irmak Bircan, Funda Cicek, Altan Essizoglu, Cagatay Karsidag, Murat Erkiran
No abstract text is available yet for this article.
September 6, 2016: Journal of Sex & Marital Therapy
Shatha A Alduraywish, Marie Standl, Caroline J Lodge, Michael J Abramson, Katrina J Allen, Bircan Erbas, Andrea von Berg, Joachim Heinrich, Adrian J Lowe, Shyamali C Dharmage
BACKGROUND: The march from early aeroallergen sensitization to subsequent respiratory allergy is well established, but it is unclear whether early life food sensitization precedes and further increases risk of allergic airway disease. OBJECTIVE: To assess the association between food sensitization in the first 2 years of life and subsequent asthma and allergic rhinitis by age 10-12 years. METHODS: We used data from two independent cohorts: the high-risk Melbourne Atopic Cohort Study (MACS) (n = 620) and the population-based LISAplus (n = 3094)...
September 3, 2016: Pediatric Allergy and Immunology
Salih Hattapoğlu, Cemil Göya, Cihad Hamidi, Bekir Taşdemir, Bircan Alan, Mehmet Sedat Durmaz, Memik Teke, Faysal Ekici
OBJECTIVES: The aim of our study was to evaluate the shear wave velocity (SWV) of parathyroid lesions by point shear wave elastography (SWE) and to compare their stiffness with that of thyroid nodules and normal thyroid parenchyma quantitatively. METHODS: Thirty-six patients considered to have parathyroid disorders by clinical and laboratory tests and scintigraphy were enrolled in the study between January 2012 and February 2015. Conventional sonography, Doppler sonography, and the Virtual Touch tissue quantification (VTQ) method of point SWE (Siemens Medical Solutions, Mountain View, CA) were conducted with a linear transducer (4-9 MHz) while the patients were in the supine position...
October 2016: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
Salih Hattapoğlu, Cemil Göya, Serkan Arslan, Bircan Alan, Faysal Ekici, Güven Tekbaş, İsmail Yıldız, Cihad Hamidi
PURPOSE: To demonstrate the difference in tissue stiffness by comparing the value of the shear wave velocity (SWV) of postoperative undescended testicles with that of normal testes. METHODS: This study included 39 patients and 30 healthy controls. US and p-SWE (VTQ) were performed using with a linear probe (4-9MHz). Forty-seven operated undescended testicles comprised "Group A", 27 testes with normal scrotal placement since birth in patient population comprised "Group B"...
December 2016: Ultrasonics
H I Gözü, S Özçelik, M Aloğlu, A Şahin, S Temiz, A Dayan, H Cengiz, Y Tütüncü, R Bircan
The D727E germline polymorphism in the thyroid-stimulating hormone receptor gene (TSHR) may cause genetic susceptibility to the development of goiter. Therefore, in this study we investigated allele frequencies and genotype distributions of the TSHR D727E polymorphism, their association with clinical parameters, and the development of goiter in the Turkish population. We investigated the TSHR D727E polymorphism in 123 patients and 97 healthy subjects using the polymerase chain reaction-restriction fragment length polymorphism technique...
2016: Genetics and Molecular Research: GMR
Rachel Tham, Don Vicendese, Shyamali Dharmage, Rob J Hyndman, Ed Newbigin, Emma Lewis, Molly O'Sullivan, Adrian J Lowe, Philip Taylor, Philip Bardin, Mimi L K Tang, Michael J Abramson, Bircan Erbas
BACKGROUND: Childhood asthma is a significant public health problem and severe exacerbations can result in diminished quality of life and hospitalisation. OBJECTIVE: To examine the contribution of outdoor fungi to childhood and adolescent asthma hospitalisations. METHODS: The Melbourne Air Pollen Children and Adolescent (MAPCAH) study is a case-crossover study of 644 children and adolescents (aged 2-17 years) hospitalised for asthma. MAPCAH collected individual data on human rhinovirus (HRV) infection and sensitisation to Alternaria and Cladosporium; and daily counts of ambient concentrations of fungal spores, pollen and air pollutants...
August 11, 2016: Journal of Allergy and Clinical Immunology
Sevim Yavaş, Meltem Arzu Yetkin, Bircan Kayaaslan, Aliye Baştuğ, Halide Aslaner, Ayşe But, Dilek Kanyilmaz, Berrin Sari, Esragül Akinci, Hürrem Bodur
BACKGROUND/AIM: Acinetobacter baumannii (A. baumannii) is one of the most common healthcare-associated infectious agents worldwide. The aim of this study was to investigate the in vitro synergistic activities of several antibiotic combinations against carbapenem-resistant (CR) A. baumannii isolates. MATERIALS AND METHODS: Eighteen CR A. baumannii strains were isolated from the patients who were hospitalized in the intensive care unit between June 2012 and August 2012...
2016: Turkish Journal of Medical Sciences
Sümeyye Kazancioğlu, Esragül Akinci, Aliye Baştuğ, Bircan Kayaaslan, Ayşe But, Halide Aslaner, Selim Sırrı Eren, Meltem Arzu Yetkin, Hurrem Bodur
BACKGROUND/AIM: This study was performed to identify the characteristics distinguishing fatal and nonfatal cases of patients diagnosed with Crimean-Congo hemorrhagic fever (CCHF). MATERIALS AND METHODS: A total of 92 patients with confirmed diagnosis of CCHF in 2009-2013 were included in the study. RESULTS: A high level of urea and aPTT on the third day of hospital stay, diarrhea, somnolence, and the interval from the beginning of the symptoms to hospital admission were independently associated with fatality...
2016: Turkish Journal of Medical Sciences
Davide Calebiro, Elisa S Grassi, Markus Eszlinger, Cristina L Ronchi, Amod Godbole, Kerstin Bathon, Fabiana Guizzardi, Tiziana de Filippis, Knut Krohn, Holger Jaeschke, Thomas Schwarzmayr, Rifat Bircan, Hulya Iliksu Gozu, Seda Sancak, Marek Niedziela, Tim M Strom, Martin Fassnacht, Luca Persani, Ralf Paschke
Autonomous thyroid adenomas (ATAs) are a frequent cause of hyperthyroidism. Mutations in the genes encoding the TSH receptor (TSHR) or the Gs protein α subunit (GNAS) are found in approximately 70% of ATAs. The involvement of other genes and the pathogenesis of the remaining cases are presently unknown. Here, we performed whole-exome sequencing in 19 ATAs that were paired with normal DNA samples and identified a recurrent hot-spot mutation (c.1712A>G; p.Gln571Arg) in the enhancer of zeste homolog 1 (EZH1) gene, which codes for a catalytic subunit of the polycomb complex...
September 1, 2016: Journal of Clinical Investigation
Gamze Çelmeli, Doğa Türkkahraman, Yusuf Çürek, Jayne Houghton, Sema Akçurin, İffet Bircan
Wolfram syndrome (WS) is an autosomal recessive disorder caused by mutations in WFS1 gene. The main clinical features include diabetes insipidus (DI), diabetes mellitus (DM), optic atrophy (OA) and deafness (D) with other variable clinical manifestations. The aim of this paper is to present three cases of WS from three unrelated Turkish families with their clinical and genetic characteristics. The first two cases developed all symptoms of the disease in the first decade. Heterozygous father of the case two was symptomatic with bilateral deafness...
July 27, 2016: Journal of Clinical Research in Pediatric Endocrinology
Bircan Alan, Senem Tunç, Elif Agacayak, Aslan Bilici
OBJECTIVE: To assess the value of placental shear wave velocity (SWV) measurement by acoustic radiation force impulse (ARFI) imaging for the diagnosis of pre-eclampsia and to determine the relationship between the SWV and the severity of pre-eclampsia. METHODS: A prospective study was performed at a center in Turkey between August 2014 and March 2015. The study included consecutive pregnant women in the second or third trimester diagnosed with pre-eclampsia and healthy pregnant women without pre-eclampsia of similar ages...
October 2016: International Journal of Gynaecology and Obstetrics
Cenk Aypak, Özlem Türedi, Mustafa A Bircan, Gul M Civelek, Mine Araz
[Purpose] Osteoporosis is an inflammatory disease, and platelets play a critical role in bone remodeling. Mean platelet volume has been shown to be influenced by inflammation. Our aim was to evaluate the relationship between mean platelet volume and bone mineral density in postmenopausal women. [Subjects and Methods] The records of female patients who had been referred to a tertiary hospital for bone mineral density analysis were retrospectively reviewed. [Results] A total of 175 patients (mean age: 61.3 ± 9...
June 2016: Journal of Physical Therapy Science
Gayan Bowatte, Caroline J Lodge, Luke D Knibbs, Adrian J Lowe, Bircan Erbas, Martine Dennekamp, Guy B Marks, Graham Giles, Stephen Morrison, Bruce Thompson, Paul S Thomas, Jennie Hui, Jennifer L Perret, Michael J Abramson, Haydn Walters, Melanie C Matheson, Shyamali C Dharmage
BACKGROUND: Traffic-related air pollution (TRAP) exposure is associated with allergic airway diseases and reduced lung function in children, but evidence concerning adults, especially in low-pollution settings, is scarce and inconsistent. OBJECTIVES: We sought to determine whether exposure to TRAP in middle age is associated with allergic sensitization, current asthma, and reduced lung function in adults, and whether these associations are modified by variants in Glutathione S-Transferase genes...
May 24, 2016: Journal of Allergy and Clinical Immunology
Bircan Alan, Murat Kapan, Memik Teke, Salih Hattapoğlu, Zülfü Arıkanoğlu
OBJECTIVE: The objectives of this study were to investigate the relationship between the segmental localization of liver hydatid cyst by computed tomography (CT) and the presence of cystobiliary communication (CBC) and to identify the risk factors for CBC. PATIENTS AND METHODS: One hundred and eleven of 163 patients who underwent liver hydatid surgery between January 2011 and September 2014 were included in this study and analyzed retrospectively. The size, number, stage, and segmental and lobar localization of the cysts were investigated by CT...
2016: Therapeutics and Clinical Risk Management
Eyup Kulah, Umit Ozcelik, Halime Cevik, Huseyin Yüce Bircan, Feza Y Karakayali
OBJECTIVES: Donor kidney measurements may affect outcomes of transplanted allografts. We tested allograft and recipient measurements on kidney allograft outcomes. In this study, we compared the effects of kidney allograft volumes, which were measured using computed tomographic angiography before transplant, and allograft weight, which was measured during surgery, in relation to the recipient's body weight and body mass index on kidney function at 6 and 12 months after transplant. MATERIAL AND METHODS: We included 74 patients (40 female and 34 male patients, mean age of 50...
June 29, 2016: Experimental and Clinical Transplantation
Azmi Yerlikaya, Elif Erdoğan, Emrah Okur, Şerife Yerlikaya, Bircan Savran
Glucose-regulated protein 78 kDa/binding immunoglobulin protein (GRP78/BIP) is a well-known endoplasmic reticulum (ER) chaperone protein regulating ER stress by facilitating protein folding, assembly and Ca(2+) binding. GRP78 is also a member of the heat shock protein 70 gene family and induces tumor cell survival and resistance to chemotherapeutics. Bortezomib is a highly specific 26S proteasome inhibitor that has been approved as treatment for patients with multiple myeloma. The present study first examined the dose- and time-dependent effects of bortezomib on GRP78 expression levels in the highly metastatic mouse breast cancer 4T1 cell line using western blot analysis...
July 2016: Oncology Letters
Melanie C Matheson, Michael J Abramson, Katrina Allen, Geza Benke, John A Burgess, James G Dowty, Bircan Erbas, Iain H Feather, Peter A Frith, Graham G Giles, Lyle C Gurrin, Garun S Hamilton, John L Hopper, Alan L James, Mark A Jenkins, David P Johns, Caroline J Lodge, Adrian J Lowe, James Markos, Stephen C Morrison, Jennifer L Perret, Melissa C Southey, Paul S Thomas, Bruce R Thompson, Richard Wood-Baker, Eugene Haydn Walters, Shyamali C Dharmage
No abstract text is available yet for this article.
June 6, 2016: International Journal of Epidemiology
Umit Ozcelik, Yahya Ekici, Huseyin Yuce Bircan, Cem Aydogan, Suna Turkoglu, Ozlem Ozen, Gokhan Moray, Mehmet Haberal
BACKGROUND To investigate the effects of platelet-rich plasma on tissue maturation and burn healing in an experimental partial-thickness burn injury model. MATERIAL AND METHODS Thirty Wistar albino rats were divided into 3 groups of 10 rats each. Group 1 (platelet-rich plasma group) was exposed to burn injury and topical platelet-rich plasma was applied. Group 2 (control group) was exposed to burn injury only. Group 3 (blood donor group) was used as blood donors for platelet-rich plasma. The rats were killed on the seventh day after burn injury...
2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Bekir Aras, Raziye Akçilar, F Emel Koçak, Havva Koçak, Bircan Savran, Hüseyin Metineren, Yasin Tuğrul Karakuş, Mehmet Yücel
BACKGROUND: The aim of this study was to investigate the potential protective effect of ukrain on an experimental kidney injury model induced by ischemia and reperfusion (IR) in rats. MATERIAL AND METHODS: A total of 24 male Sprague-Dawley rats were equally and randomly separated into three groups as follows: group-1: controls (C; only laparotomy); group 2: renal ischemia-reperfusion (IR; occlusion of the renal artery for 30 min and 2 h of reperfusion); and group 3: ukrain treatment and IR applied group (U + IR; occlusion of the renal artery for 30 min and 2 h of reperfusion; ukrain was intraperitoneally administered 1 h before the IR process)...
May 15, 2016: Journal of Surgical Research
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