keyword
https://read.qxmd.com/read/38242607/erratum-to-glomerular-filtration-rate-estimated-by-cockcroft-gault-formula-better-predicts-anti-xa-levels-than-modification-of-the-diet-in-renal-disease-equation-in-older-patients-with-prophylactic-enoxaparin
#1
B Dufour, M Toussaint-Hacquard, A Kearney-Schwartz, M D P Manckoundia, M-C Laurain, L Joly, J Deibener, D Wahl, T Lecompte, A Benetos, Christine Perret-Guillaume
No abstract text is available yet for this article.
December 2023: Journal of Nutrition, Health & Aging
https://read.qxmd.com/read/37991392/pharmacokinetics-and-pharmacodynamics-of-direct-oral-anticoagulants
#2
REVIEW
B Hindley, G Y H Lip, A P McCloskey, P E Penson
INTRODUCTION: Direct oral anticoagulants (DOACs) have overtaken vitamin K antagonists to become the most widely used method of anticoagulation for most indications. Their stable and predictable pharmacokinetics combined with relatively simple dosing, and the absence of routine monitoring has made them an attractive proposition for healthcare providers. Despite the benefits of DOACs as a class, important differences exist between individual DOAC drugs in respect of their pharmacokinetic and pharmacodynamic profiles with implications for dosing and reversal in cases of major bleeding...
December 2023: Expert Opinion on Drug Metabolism & Toxicology
https://read.qxmd.com/read/37910057/-estimating-renal-function-in-older-patients-which-is-the-best-formula
#3
JOURNAL ARTICLE
Francesco Cilla, Ilaria Sabione, Menno Pruijm, Marc Humbert, Patrizia D'Amelio
An accurate assessment of renal function is crucial for the diagnosis and follow up of kidney diseases. However, there is currently no clear consensus on the optimal method on how to measure renal function in older individuals (>65 years of age). The Cockcroft-Gault formula, the MDRD equation, and the CKD-EPI equation are among the most used equations. However, they have several limitations when applied to the older population. Other formulas specifically developed for the older, such as the Berlin Initiative Study (BIS) and the Full Age Spectrum (FAS) equation, demonstrated conflicting results and require more external validation...
November 1, 2023: Revue Médicale Suisse
https://read.qxmd.com/read/37850285/-effect-of-a-simple-kidney-cyst-on-renal-function
#4
JOURNAL ARTICLE
V A Malkhasyan, T B Makhmudov, Yu Sh Gilfanov, I V Semenyakin, S O Sukhikh, D Y Pushkar
INTRODUCTION: Renal cysts are a common disease that occurs at a rate of 7-10%. Currently there are no clinical recommendations for the treatment of patients with simple renal cysts. In the current literature there is some evidence that a simple renal cyst has negative effects on renal function. Decreased renal function occurs due to partial atrophy and loss of the renal parenchyma (in the "crater" area at the base of the cyst) caused by compression. Therefore, the efforts to analyze the effect of simple kidney cysts on kidney function and identify the characteristics of the cyst that affect renal function to determine the indications for surgical treatment remains a substantial task...
September 2023: Urologii︠a︡
https://read.qxmd.com/read/37425322/renal-injury-biomarkers-and-myositis-an-understudied-aspect-of-disease-prospective-study-in-the-myocite-cohort
#5
JOURNAL ARTICLE
Edoardo Conticini, R Naveen, Parikshit Sen, Mantabya Singh, Upendra Rathore, Anamika Kumari Anuja, Mohit Kumar Rai, Brijesh Yadav, Narayan Prasad, Vikas Agarwal, Latika Gupta
INTRODUCTION: The mechanisms leading to chronic kidney disease (CKD) in patients with idiopathic inflammatory myopathies (IIMs) are poorly understood. We assessed the prevalence of subclinical renal injury in patients with IIMs, through elevation in biomarker levels of tubular injury and fibrosis (NGAL, KIM1, Activin A, CD163, and Cys-c), and assessed differences between subtypes of IIMs, and the effect of disease activity and duration. MATERIALS AND METHODS: Clinical data, core set measures, sera and urine were prospectively collected from all patients enrolled in the MyoCite cohort from 2017 to 2021...
2023: Frontiers in Medicine
https://read.qxmd.com/read/37382749/chapter-1-evaluation-of-kidney-function-in-patients-undergoing-anticancer-drug-therapy-from-clinical-practice-guidelines-for-the-management-of-kidney-injury-during-anticancer-drug-therapy-2022
#6
JOURNAL ARTICLE
Satoru Muto, Takeshi Matsubara, Takamitsu Inoue, Hiroshi Kitamura, Kazuhiro Yamamoto, Taisuke Ishii, Masahiko Yazawa, Ryohei Yamamoto, Naoto Okada, Kiyoshi Mori, Hiroyuki Yamada, Takashige Kuwabara, Atsushi Yonezawa, Takuya Fujimaru, Haruna Kawano, Hideki Yokoi, Kent Doi, Junichi Hoshino, Motoko Yanagita
The prevalence of CKD may be higher in patients with cancer than in those without due to the addition of cancer-specific risk factors to those already present for CKD. In this review, we describe the evaluation of kidney function in patients undergoing anticancer drug therapy. When anticancer drug therapy is administered, kidney function is evaluated to (1) set the dose of renally excretable drugs, (2) detect kidney disease associated with the cancer and its treatment, and (3) obtain baseline values for long-term monitoring...
June 29, 2023: International Journal of Clinical Oncology
https://read.qxmd.com/read/37363695/comparison-of-three-glomerular-filtration-rate-estimating-equations-with-24-hour-urine-creatinine-clearance-measurement-in-potential-living-kidney-donors
#7
JOURNAL ARTICLE
Fernando Giron-Luque, Andrea Garcia-Lopez, Yenny Baez-Suarez, Nasly Patino-Jaramillo
BACKGROUND: The accuracy of the measurement of renal function in potential living kidney donors (PLKD) is essential. The direct measurement of glomerular filtration rate (mGFR) has been considered the "gold standard." The estimated GFR (eGFR) with 24-hour urinary creatinine clearance (CrCl) is frequently used because of its availability. We aim to evaluate the correlation and agreement of eGFR using serum-based creatinine formulas (Cockcroft-Gault, MDRD, and CKD-EPI) and the eGFR based on 24-hour urinary CrCl to evaluate kidney function in PLKD...
2023: International Journal of Nephrology
https://read.qxmd.com/read/37351560/adjustment-of-creatinine-clearance-for-carboplatin-dosing-in-calvert-s-formula-and-clinical-efficacy-for-lung-cancer
#8
JOURNAL ARTICLE
Takahiro Hatta, Tetsunari Hase, Toru Hara, Tomoki Kimura, Eiji Kojima, Takashi Abe, Yoshitsugu Horio, Yasuhiro Goto, Naoya Ozawa, Naoyuki Yogo, Hirofumi Shibata, Tomoya Shimokata, Tetsuya Oguri, Masashi Yamamoto, Kiyoshi Yanagisawa, Masahiko Ando, Yuichi Ando, Masashi Kondo, Makoto Ishii, Yoshinori Hasegawa
BACKGROUND: The Cockcroft-Gault formula is commonly used as a substitute for glomerular filtration rate (GFR) in Calvert's formula for carboplatin dosing, where adjusting serum creatinine measured using the enzymatic method with 0.2 mg/dL has been suggested in Japan. However, the effects of these adjustments on efficacy in patients with non-small-cell lung cancer remain unknown. METHODS: We conducted a post hoc analysis of the PREDICT1 study (CJLSG1201), a multicenter prospective observational trial of carboplatin-pemetrexed...
June 23, 2023: Cancer Medicine
https://read.qxmd.com/read/37229879/carboplatin-dosing-in-the-treatment-of-ovarian-cancer-an-nrg-oncology-group-study
#9
JOURNAL ARTICLE
Aaron M Praiss, Austin Miller, Judith Smith, Stuart M Lichtman, Michael Bookman, Carol Aghajanian, Paul Sabbatini, Floor Backes, David E Cohn, Peter Argenta, Michael Friedlander, Michael J Goodheart, David G Mutch, David M Gershenson, Krishnansu S Tewari, Robert M Wenham, Andrea E Wahner Hendrickson, Roger B Lee, Heidi Gray, Angeles Alvarez Secord, Linda Van Le, Roisin E O'Cearbhaill
OBJECTIVE: To determine the effects of using National Comprehensive Cancer Network (NCCN) guidelines to estimate renal function on carboplatin dosing and explore adverse effects associated with a more accurate estimation of lower creatinine clearance (CrCl). METHODS: Retrospective data were obtained for 3830 of 4312 patients treated on GOG182 (NCT00011986)-a phase III trial of platinum-based chemotherapy for advanced-stage ovarian cancer. Carboplatin dose per patient on GOG182 was determined using the Jelliffe formula...
May 23, 2023: Gynecologic Oncology
https://read.qxmd.com/read/37194167/optimizing-carboplatin-dosing-by-an-improved-prediction-of-carboplatin-clearance-using-a-ct-enhanced-estimate-of-renal-function
#10
JOURNAL ARTICLE
L Molenaar-Kuijsten, T T Pieters, W B Veldhuis, P Moeskops, E J Rijkhorst, T P C Dorlo, J H Beijnen, N Steeghs, M B Rookmaaker, A D R Huitema
AIM: Carboplatin is generally dosed based on a modified Calvert formula, in which the Cockcroft-Gault based creatinine clearance (CRCL) is used as proxy for the glomerular filtration rate (GFR). The Cockcroft-Gault formula (CG) overpredicts CRCL in patients with an aberrant body composition. The CT-enhanced estimate of RenAl FuncTion (CRAFT) was developed to compensate for this overprediction. We aimed to evaluate whether carboplatin clearance is better predicted by CRCL based on the CRAFT compared to the CG...
May 16, 2023: British Journal of Clinical Pharmacology
https://read.qxmd.com/read/37167167/-prospects-and-possibilities-for-the-treatment-of-patients-with-long-covid-19-syndrome
#11
JOURNAL ARTICLE
M M Tanashyan, A A Raskurazhev, P I Kuznetsova, P A Bely, K I Zaslavskaya
AIM: To study the efficacy and safety of a drug product based on the succinic acid complex with trimethylhydrazine used to treat patients with asthenic syndrome after a new coronavirus infection (COVID-19). MATERIALS AND METHODS: A prospective, multicenter, comparative, randomized, double-blind, placebo-controlled study of the safety and efficacy of sequential therapy with Brainmax® enrolled 160 patients 12-16 weeks after coronavirus infection (no more than 12 months)...
December 26, 2022: Terapevticheskiĭ Arkhiv
https://read.qxmd.com/read/37140726/comparison-of-three-renal-function-formulas-for-ganciclovir-valganciclovir-dose-individualization-in-cmv-infected-solid-organ-transplantation-patients-using-a-population-approach
#12
JOURNAL ARTICLE
Panagiotis Nikolaos Lalagkas, Jorge Iliou, Raul Rigo, Marta Miarons, Beatriz Fernández-Alarcon, Oriol Bestard, Josep M Cruzado, Edoardo Melilli, Joan Torras, Josep M Grinyó, Nuria Lloberas, Helena Colom
BACKGROUND AND OBJECTIVE: The gold standard treatment of established cytomegalovirus infection or prevention in solid organ transplantation is the intravenous administration of ganciclovir (GCV) or oral administration of valganciclovir (VGCV), both adjusted to the renal function. In both instances, there is a high interindividual pharmacokinetic variability, mainly owing to the wide range of variation of both the renal function and body weight. Therefore, accurate estimation of the renal function is crucial for GCV/VGCV dose optimization...
June 2023: Clinical Pharmacokinetics
https://read.qxmd.com/read/37103030/long-term-renal-function-after-catheter-ablation-of-atrial-fibrillation
#13
JOURNAL ARTICLE
Vladan Kovačević, Milan M Marinković, Aleksandar Kocijančić, Nikola Isailović, Jelena Simić, Miroslav Mihajlović, Vera Vučićević, Tatjana S Potpara, Nebojša M Mujović
Background: Atrial fibrillation (AF) is associated with the development and progression of chronic kidney disease (CKD). This study evaluated the impact of long-term rhythm outcome after catheter ablation (CA) of AF on renal function. Methods and results: The study group included 169 consecutive patients (the mean age was 59.6 ± 10.1 years, 61.5% were males) who underwent their first CA of AF. Renal function was assessed by eGFR (using the CKD-EPI and MDRD formulas), and by creatinine clearance (using the Cockcroft-Gault formula) in each patient before and 5 years after index CA procedure...
March 31, 2023: Journal of Cardiovascular Development and Disease
https://read.qxmd.com/read/37101162/diagnostic-value-of-neutrophil-gelatinase-associated-lipocalin-ngal-as-an-early-biomarker-for-detection-of-renal-failure-in-hypertensives-a-case-control-study-in-a-regional-hospital-in-ghana
#14
JOURNAL ARTICLE
Mark Danquah, William K B A Owiredu, B A Eghan Jnr, Dorcas Serwaa, Enoch Odame Anto, Maxwell Owusu Peprah, Christian Obirikorang, Linda A Fondjo
BACKGROUND: Renal failure is one of the most serious vascular effects of hypertension. For better therapy and prevention of complications, early kidney disease identification in these patients is absolutely essential. However, current studies have proposed plasma Neutrophil Gelatinase Associated Lipocalin (pNGAL) to be a better biomarker comparative to serum creatinine (SCr). This study assessed the diagnostic utility of plasma neutrophil gelatinase-associated lipocalin (pNGAL) as a biomarker for early nephropathy diagnosis in hypertensive individuals...
April 26, 2023: BMC Nephrology
https://read.qxmd.com/read/37090449/clinical-associations-with-the-differences-in-rivaroxaban-dosing-in-patients-with-atrial-fibrillation-stratified-by-three-renal-function-formulae
#15
JOURNAL ARTICLE
Juhaina Salim Al-Maqbali, Abdullah M Al Alawi, Maria Al-Adawi, Zubaida Al-Falahi, Asia Al-Azizi, Kholoud Al Badi, Mohamed Al Rawahi
BACKGROUND: Clinical trials used Cockcroft-Gault (CG) formula to calculate the estimated glomerular filtration rate (eGFR) in order to dose rivaroxaban for patients with atrial fibrillation (AF). OBJECTIVES: The aim of this study is to evaluate rivaroxaban dosing appropriateness in patients with AF with or without renal impairment based on the CG formula and other formulae, including Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation and the isotope dilution mass spectrometry (IDMS) traceable Modification of Diet in Renal Disease (MDRD) Study equation and the associated clinical outcomes...
2023: Pharmacy Practice
https://read.qxmd.com/read/37057998/estimating-kidney-function-in-patients-with-cancer-a-narrative-review
#16
REVIEW
Sophie E Claudel, Malini Gandhi, Ankit B Patel, Ashish Verma
AIM: Accurate evaluation of glomerular filtration rate (GFR) is crucial in Oncology as drug eligibility and dosing depend on estimates of GFR. However, there are no clear guidelines on the optimal method of determining kidney function in patients with cancer. We aimed to summarize the evidence on estimation of kidney function in patients with cancer. METHODS: We searched PubMed for literature discussing the performance of GFR estimating equations in patients with malignancy to create a table of the evidence for creatinine- and cystatin c-based equations...
April 14, 2023: Acta Physiologica
https://read.qxmd.com/read/37021950/renal-function-estimating-equations-performance-during-pregnancy-and-postpartum
#17
JOURNAL ARTICLE
Dina E Zaghloul, Rachel Ryu, Bryan Kestenbaum, Chase Smith, Emily Fay, Mary F Hebert
INTRODUCTION: Dosing of renally-eliminated medications during pregnancy can be challenging due to marked changes in renal function. OBJECTIVES: The objectives of this study were to evaluate the performance of renal function estimating equations compared to measured creatinine clearance (CrCl) during pregnancy and postpartum and to evaluate which body weight (pre-pregnancy weight (PPW), actual body weight (ABW), and ideal body weight (IBW)) provides the best performance...
April 6, 2023: Pharmacotherapy
https://read.qxmd.com/read/37016059/creatinine-clearance-in-acute-brain-injury-a-comparison-of-methods
#18
JOURNAL ARTICLE
Elisabete Monteiro, Mariana Fraga Pereira, Isaac Barroso, Cláudia Camila Dias, Marek Czosnyka, José Artur Paiva, Celeste Dias
BACKGROUND: Currently, the measurement of glomerular filtration rate is very complex and costly, so its daily evaluation is performed using endogenous markers, of which creatinine is the most frequently used. It allows the estimation of glomerular filtration rate by means of its clearance or by formulas based on its serum and urine concentration. Augmented renal clearance (ARC) is frequent among critically ill patients and is defined as creatinine clearance (CrCl) > 130 ml/min/1...
April 4, 2023: Neurocritical Care
https://read.qxmd.com/read/36892077/variability-in-nonvitamin-k-oral-anticoagulant-dose-eligibility-and-adjustment-according-to-renal-formulae-and-clinical-outcomes-in-patients-with-atrial-fibrillation-with-and-without-chronic-kidney-disease-insights-from-orbit-af-ii
#19
JOURNAL ARTICLE
Ren Jie Robert Yao, DaJuanicia N Holmes, Jason G Andrade, Adeera Levin, Jonathan P Piccini, Christopher B Fordyce
Background Nonvitamin K oral anticoagulants require dose adjustment based on kidney function.The most common estimate of kidney function employed in clinical practice is estimated glomerular filtration rate (eGFR); however, product monographs recommend the use of the Cockcroft-Gault estimated creatinine clearance (eCrCl) for dose adjustment. Methods and Results The authors included patients enrolled in the ORBIT-AF II (Outcomes Registry for Better Informed Treatment of Atrial Fibrillation AF II) trial. Dosing was considered inappropriate when use of eGFR resulted in a lower (undertreatment) or higher (overtreatment) dose than that recommended by the eCrCl...
March 21, 2023: Journal of the American Heart Association
https://read.qxmd.com/read/36675782/clinical-relevance-of-a-vancomycin-24-h-area-under-the-concentration-time-curve-values-using-different-renal-function-equations-in-bayesian-dosing-software
#20
JOURNAL ARTICLE
Hyun-Ki Kim, Tae-Dong Jeong
With the updated 2020 vancomycin therapeutic drug monitoring (TDM) guidelines suggesting a ratio of area under the curve over 24 h to a minimum inhibitory concentration (AUC24 /MIC) as a target from the Infectious Diseases Society of America, an accurate estimation of AUC24 has become more critical. We aim to compare the AUC24 using Bayesian dosing software according to various estimated glomerular filtration rate (eGFR) equations in order to analyze the clinical impact of eGFR in vancomycin TDM. We reviewed the TDM dataset of 214 adult patients and analyzed the AUC24 values from various renal function equations, including the Cockcroft-Gault (C-G), the modification of diet in renal disease (MDRD), the chronic kidney disease epidemiology collaboration (CKD-EPI), and the revised Lund-Malmö...
January 5, 2023: Journal of Personalized Medicine
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