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Cockcroft-gault formula

Prashanth Rajagopalan, Georgi Abraham, Yuvaram Nv Reddy, Ravivarman Lakshmanasami, M L Prakash, Yogesh Nv Reddy
This population-based prospective study was undertaken in Mahatma Gandhi Medical College to estimate the renal function in young healthy Indian adults. A young healthy heterogeneous Indian cohort comprising 978 individuals, predominantly medical students, was assessed by a detailed questionnaire, and variables such as height, weight, body mass index (BMI), birth weight, and blood pressure were documented. Laboratory investigations included serum creatinine, serum cystatin C, blood sugar, urine protein, and imaging of the kidneys with ultrasound...
2016: International Journal of Nephrology and Renovascular Disease
Karl J Neff, Gregory Baud, Violeta Raverdy, Robert Caiazzo, Helene Verkindt, François Pattou, Carel W le Roux, Christian Noel
PURPOSE: This study examines the effect of Roux-en-Y gastric bypass (RYGB) and laparoscopic adjustable gastric banding (LAGB) on renal function for at least 5 years post-operatively in a tertiary referral center for bariatric surgery. MATERIALS AND METHODS: This prospective cohort study of patients undergoing RYGB and LAGB measured renal function, blood pressure, and diabetes status pre-operatively and then 1 and 5 years post-operatively. Renal function was assessed using the Modification of Diet in Renal Disease (MDRD), Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI), and Cockcroft-Gault formulae...
September 14, 2016: Obesity Surgery
S Avinash, V P Singh, A K Agarwal, S Chatterjee, V Arya
BACKGROUND: Cystatin C is a low molecular weight protein produced by all nucleated human cells, with a stable production rate. Its levels are not influenced by inflammation, infections, hepatic or renal diseases, or by dietary or constitutional factors. We compared serum cystatin C and serum creatinine based predicting equations to estimate glomerular filteration rate (GFR) in type 2 diabetes mellitus, using the staging of chronic kidney disease (CKD) defined by the National Kidney Foundation...
November 2015: Journal of the Association of Physicians of India
Ryutaro Ishitsuka, Jun Miyazaki, Daishi Ichioka, Takamitsu Inoue, Susumu Kageyama, Mikio Sugimoto, Koji Mitsuzuka, Yoshiyuki Matsui, Yusuke Shiraishi, Hidefumi Kinoshita, Hironobu Wakeda, Takeshi Nomoto, Eiji Kikuchi, Koji Kawai, Hiroyuki Nishiyama
BACKGROUND: The Kidney Disease: Improving Global Outcomes group (KDIGO) defined acute kidney injury (AKI) as an elevation of serum creatinine (sCR) exceeding 0.3 mg/dl within 48 h. The widely used adverse events criteria for chemotherapy, Common Toxicity Criteria for Adverse Events Version 4.0 (CTCAE v4.0), also defined AKI as sCR exceeding 0.3 mg/dl, but with no provision of a time course. Here, we attempted to clarify the impact of AKI (CTCAE v4.0) during cisplatin-based chemotherapy on clinical outcome of patients with advanced urothelial cancer (UC)...
August 26, 2016: Clinical and Experimental Nephrology
Belkis Erbas, Murat Tuncel
Theranostics labeled with Y-90 or Lu-177 are highly efficient therapeutic approaches for the systemic treatment of various cancers including neuroendocrine tumors and prostate cancer. Peptide receptor radionuclide therapy (PRRT) has been used for many years for metastatic or inoperable neuroendocrine tumors. However, renal and hematopoietic toxicities are the major limitations for this therapeutic approach. Kidneys have been considered as the "critical organ" because of the predominant glomerular filtration, tubular reabsorption by the proximal tubules, and interstitial retention of the tracers...
September 2016: Seminars in Nuclear Medicine
Jeffrey F Barletta, Alicia J Mangram, Marilyn Byrne, Alexzandra K Hollingworth, Joseph F Sucher, Francis R Ali-Osman, Gina R Shirah, James K Dzandu
BACKGROUND: An accurate assessment of creatinine clearance (CrCl) is essential when dosing medications in critically ill trauma patients. Trauma patients are known to experience augmented renal clearance (i.e., CrCl ≥130 ml/min) and the use of CrCl estimations may be inaccurate leading to under/over dosing of medications. As such, our level I trauma center began using measured CrCl from timed urine collections to better assess CrCl. This study sought to determine the prevalence of augmented renal clearance and the accuracy of calculated CrCl in critically ill trauma patients...
August 16, 2016: Journal of Trauma and Acute Care Surgery
D Terentes-Printzios, C Vlachopoulos, G Vyssoulis, P Pietri, N Ioakeimidis, M Abdelrasoul, P Xaplanteris, E Paschalidis, D Tousoulis
OBJECTIVE: Hypertension is associated with higher cardiovascular risk as well as several markers of subclinical target organ damage (TOD). Total arterial compliance (TAC) has been recognized as an independent risk factor for cardiovascular events. We hypothesized that there is a relationship between TAC and markers of TOD in never-treated hypertensives. DESIGN AND METHOD: We enrolled 990 consecutive essential hypertensives (mean age 52.6 ± 12.2 years, 526 males) without known cardiovascular disease (CVD)...
September 2016: Journal of Hypertension
G Norton, H L Booysen, A Raymond, P Sareli, H-C Hsu, P H Dessein, A J Woodiwiss
OBJECTIVE: The recent Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation for estimated glomerular filtration rate (eGFR) is recommended for use in European populations. However, because the relationship between creatinine and GFR varies between ethnicities, the CKD-EPI equation may not perform as well in African as it does in Caucasian populations. We aimed to identify whether the CKD-EPI equation is more closely associated with end organ changes than previous equations in a group of black African descent...
September 2016: Journal of Hypertension
Ł Czyżewski, J Wyzgał, E Czyżewska, A Kurowski, J Sierdziński, A Łabuś, Z Truszewski, Ł Szarpak
BACKGROUND: Monitoring of the function of the implanted kidney in renal transplant recipients (RTRs) is one of the superior elements of adequate therapeutic actions. The aim of this study was to assess the conventional and unconventional factors affecting the estimated glomerular filtration rate (eGFR) with the Modification of Diet in Renal Disease (MDRD), Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI), and Cockcroft-Gault (C-G) formulas among the RTRs. METHODS: The study included 144 RTRs (mean age 52 years)...
June 2016: Transplantation Proceedings
Sin-Youl Park, Kyung-Woo Lee
OBJECTIVES: To assess respective roles of serum creatinine (SCr) alone and estimated glomerular filtration rate (eGFR) as an early predictor for contrast-induced nephropathy (CIN) in elderly patients with cancer. MATERIALS AND METHODS: eGFR of 348 patients at 65years or older with malignancy who underwent contrast-enhanced computed tomography (CECT) were calculated. eGFR was calculated based on the following three equations: Chronic Kidney Disease Epidemiology Collaboration equation (CKD-EPI); Modification of Diet in Renal Disease Study (MDRD); Cockcroft-Gault (CG)...
August 1, 2016: Journal of Geriatric Oncology
Giuseppe Boriani, Cécile Laroche, Igor Diemberger, Mircea Ioachim Popescu, Lars Hvilsted Rasmussen, Lucian Petrescu, Harry J G M Crijns, Luigi Tavazzi, Aldo P Maggioni, Gregory Y H Lip
We assessed 1-year outcomes in patients with atrial fibrillation enrolled in the EurObservational Research Programme AF General Pilot Registry (EORP-AF), in relation to kidney function, as assessed by glomerular filtration rate (eGFR). In a cohort of 2398 patients (median age 69 years; 61% male), eGFR (ml/min/1.73 m(2)) calculated using the CKD-EPI formula was ≥80 in 35.1%, 50-79 in 47.2%, 30-49 in 13.9% and <30 in 3.7% of patients. In a logistic regression analysis, eGFR category was an independent predictor of stroke/TIA or death, with elevated odds ratios associated with severe to mild renal impairment, ie...
2016: Scientific Reports
Seong Hee Shim, Ki-Chul Sung, Joon Mo Kim, Mi Yeon Lee, Yu Sam Won, Jung Hoon Kim, Ki Ho Park
PURPOSE: To investigate the relationship between renal function and primary open-angle glaucoma (POAG) in a South Korean population. DESIGN: A population-based, cross-sectional survey using a multistage, stratified, probability-clustered sampling method from the Korean National Health and Nutrition Examination Survey (KNHANES). PARTICIPANTS: A total of 5971 participants at least 40 years of age were selected from the KNHANES between 2010 and 2011...
September 2016: Ophthalmology
Umezurike H Okafor, S Ahmed, O Arigbodi, S Idogun, E I Unuigbe
Petroleum products have been associated with acute and chronic kidney disease. Nigeria is a major oil producing and exporting country. The aim of this study was to screen for kidney disease in an oil producing community in Nigeria. This was a cross-sectional study carried out in Ido, Asari-Toru Local Government Area of Rivers State. All subjects were resident in the town and those aged 18 years and above were eligible. Spot urine samples were collected for dipstick urinalysis, and venous blood was collected for estimation of serum electrolyte, urea, creatinine, and lipid profile...
July 2016: Saudi Journal of Kidney Diseases and Transplantation
Atoosa Adibi, Mojgan Mortazavi, Azin Shayganfar, Sima Kamal, Roya Azad, Marzieh Aalinezhad
It is essential to ascertain the state of health and renal function of potential kidney donors before organ removal. In this regard, one of the primary steps is to estimate the donor's glomerular filtration rate (GFR). For this purpose, the modification of diet in renal disease (MDRD) and the Cockcroft-Gault (CG) formulas has been used. However, these two formulas produce different results and finding new techniques with greater accuracy is required. Measuring the renal volume from computed tomography (CT) scan may be a valuable index to assess the renal function...
July 2016: Saudi Journal of Kidney Diseases and Transplantation
Marjan Motie, Lorraine S Evangelista, Dawn Lombardo, Josiah Hoi, Tamara B Horwich, Michele Hamilton, Gregg C Fonarow
AIMS: The effect of intentional weight loss on glomerular filtration rate (GFR) in overweight and obese patients with heart failure (HF), diabetes mellitus (DM) and/or metabolic syndrome (MS) has not been studied. The purpose of the present study is to assess the short term effects of intentional weight loss on renal function in this population. MATERIALS AND METHODS: Fifty nine patients were recruited to participate in a 3-month intensive behavioral weight management intervention and received one of two standard structured energy-restricted meal plans (1200 or 1500kcal/day) based on their computed calorie deficit...
June 23, 2016: Diabetes & Metabolic Syndrome
Katsuya Kajimoto, Naoki Sato, Teruo Takano
BACKGROUND: Renal insufficiency is a well-known predictor of adverse events in patients with acute heart failure syndromes (AHFS). However, it remains unclear whether there are subgroups of AHFS patients in whom renal insufficiency is related to a higher risk of adverse events because of the heterogeneity of this patient population. Therefore, we investigated the relationship between renal insufficiency, clinical features or comorbidities, and the risk of adverse events in patients with AHFS...
June 30, 2016: European Heart Journal. Acute Cardiovascular Care
Erin A Bohula, Robert P Giugliano, Christian T Ruff, Julia F Kuder, Sabina A Murphy, Elliott M Antman, Eugene Braunwald
BACKGROUND: Edoxaban, an oral factor Xa inhibitor with 50% renal clearance, was noninferior to well-managed warfarin for stroke or systemic embolism (S/SE) prevention and reduced bleeding in patients with atrial fibrillation. We evaluated the efficacy and safety of edoxaban versus warfarin across the range of baseline creatinine clearance (CrCl) in the ENGAGE AF-TIMI 48 trial (Effective Anticoagulation With Factor Xa Next Generation in Atrial Fibrillation-Thrombolysis in Myocardial Infarction Study 48) with a focus on the higher-dose edoxaban regimen (HDER) and the upper range of CrCl...
July 5, 2016: Circulation
Iman Karimzadeh, Hossein Khalili
Serum cystatin C (Cys C) has a number of advantages over serum creatinine in the evaluation of kidney function. Apart from Cys C level itself, several formulas have also been introduced in different clinical settings for the estimation of glomerular filtration rate (GFR) based upon serum Cys C level. The aim of the present study was to compare a serum Cys C-based equation with Cockcroft-Gault serum creatinine-based formula, both used in the calculation of GFR, in patients receiving amphotericin B. Fifty four adult patients with no history of acute or chronic kidney injury having been planned to receive conventional amphotericin B for an anticipated duration of at least 1 week for any indication were recruited...
2016: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
Stijn Jonckheere, Nikolaas De Neve, Hans De Beenhouwer, Mario Berth, An Vermeulen, Jan Van Bocxlaer, Pieter Colin
OBJECTIVES: Several population pharmacokinetic models for cefepime in critically ill patients have been described, which all indicate that variability in renal clearance is the main determinant of the observed variability in exposure. The main objective of this study was to determine which renal marker best predicts cefepime clearance. METHODS: A pharmacokinetic model was developed using NONMEM based on 208 plasma and 51 urine samples from 20 ICU patients during a median follow-up of 3 days...
September 2016: Journal of Antimicrobial Chemotherapy
Naoya Niwa, Eiji Kikuchi, Matsushima Masashi, Nobuyuki Tanaka, Toru Nishiyama, Akira Miyajima, Shiro Saito, Mototsugu Oya
OBJECTIVE: The relationship between endogenous creatinine clearance (eCrCl) and renal function values obtained using mathematical formulas has not yet been fully elucidated, especially in patients with upper tract urothelial carcinoma that are treated with radical nephroureterectomy followed by cisplatin-based chemotherapy. METHODS: Sixty patients who received cisplatin-based chemotherapy for locally advanced or metastatic upper tract urothelial carcinoma after radical nephroureterectomy between 2000 and 2012 were retrospectively identified...
May 2, 2016: Clinical Genitourinary Cancer
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