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https://www.readbyqxmd.com/read/29327401/daclatasvir-and-reduced-dose-sofosbuvir-an-effective-and-pangenotypic-treatment-for-hepatitis-c-in-patients-with-egfr-30-ml-min
#1
Amit Goel, Dharmendra Singh Bhadauria, Anupma Kaul, Prashant Verma, Mayank Mehrotra, Amit Gupta, Raj Kumar Sharma, Praveer Rai, Rakesh Aggarwal
BACKGROUND & AIMS: Sofosbuvir is a key agent for HCV treatment. It is not recommended for patients with chronic kidney disease (CKD) and estimated glomerular filtration rate (eGFR) <30 mL/min. We report real-life experience of treating a cohort of CKD patients with eGFR <30 mL/min using daclatasvir and half-daily dose of sofosbuvir. METHODS: Adults patients who (i) had eGFR<30 ml/min and detectable HCV RNA and (ii) were treated with interferon and ribavirin free, DAA based regimens were included...
January 12, 2018: Nephrology
https://www.readbyqxmd.com/read/29326843/risk-of-acute-kidney-injury-in-patients-randomized-to-a-restrictive-versus-liberal-approach-to-red-blood-cell-transfusion-in-cardiac-surgery-a-substudy-protocol-of-the-transfusion-requirements-in-cardiac-surgery-iii-noninferiority-trial
#2
Amit X Garg, Nadine Shehata, Shay McGuinness, Richard Whitlock, Dean Fergusson, Ron Wald, Chirag Parikh, Sean M Bagshaw, Boris Khanykin, Alex Gregory, Summer Syed, Gregory M T Hare, Meaghan S Cuerden, Kevin E Thorpe, Judith Hall, Subodh Verma, Pavel S Roshanov, Jessica M Sontrop, C David Mazer
Background: When safe to do so, avoiding blood transfusions in cardiac surgery can avoid the risk of transfusion-related infections and other complications while protecting a scarce resource and reducing costs. This protocol describes a kidney substudy of the Transfusion Requirements in Cardiac Surgery III (TRICS-III) trial, a multinational noninferiority randomized controlled trial to determine whether the risk of major clinical outcomes in patients undergoing planned cardiac surgery with cardiopulmonary bypass is no greater with a restrictive versus liberal approach to red blood cell transfusion...
2018: Canadian Journal of Kidney Health and Disease
https://www.readbyqxmd.com/read/29296859/hispanic-ethnicity-is-associated-with-younger-age-at-presentation-but-worse-survival-in-acute-myeloid-leukemia
#3
Karine Darbinyan, Aditi Shastri, Anjali Budhathoki, Daniel Helbig, Rose Snyder, Kith Pradhan, Junaid Saleh-Esa, Noah S Kornblum, Adam F Binder, Swati Goel, Murali Janakiram, Olga Derman, Kira Gritsman, Ulrich Steidl, Ira Braunschweig, Amit Verma, Ioannis Mantzaris
SEER data and a Bronx validation cohort demonstrate that Hispanics present with AML at younger age but have shorter survival than whites.Increased frequency of high-risk mutations in Hispanics provides a potential biologic explanation for poorer outcomes in Hispanics.
November 14, 2017: Blood Advances
https://www.readbyqxmd.com/read/29241763/eltrombopag-reduces-clinically-relevant-thrombocytopenic-events-in-higher-risk-mds-and-aml
#4
Aditi Shastri, Amit K Verma
No abstract text is available yet for this article.
December 11, 2017: Lancet Haematology
https://www.readbyqxmd.com/read/29204925/ultrasound-based-triggered-drug-delivery-to-tumors
#5
REVIEW
Ankit Jain, Ankita Tiwari, Amit Verma, Sanjay K Jain
Over the past few decades, applications of ultrasound (US) in drug delivery have been documented widely for local and site-specific release of bioactives in a controlled manner, after acceptable use in mild physical therapy for tendinitis and bursitis, and for high-energy applications in fibroid ablation, cataract removal, bone fracture healing, etc. US is a non-invasive, efficient, targetable and controllable technique. Drug delivery can be enhanced by applying directed US in terms of targeting and intracellular uptake...
December 4, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/29191840/macrocytosis-and-dysplastic-anemia-is-associated-with-the-cyclin-dependent-kinase-4-6-inhibitor-palbociclib-in-metastatic-breast-cancer
#6
Jesus Anampa, Tamanna Haque, Irina Murakhovskaya, Yanhua Wang, Kimo Bachiashvili, Cristian Papazoglu, Kith Pradhan, Ulrich G Steidl, Joseph A Sparano, Amit Verma
No abstract text is available yet for this article.
November 30, 2017: Haematologica
https://www.readbyqxmd.com/read/29172480/myricetin-reduces-toxic-level-of-cag-repeats-rna-in-huntington-s-disease-hd-and-spino-cerebellar-ataxia-scas
#7
Eshan Khan, Arpita Tawani, Subodh Kumar Mishra, Arun Kumar Verma, Arun Upadhyay, Mohit Kumar, Rajat Sandhir, Amit Mishra, Amit Kumar
Huntington's disease (HD) is a neurodegenerative disorder that is caused by abnormal expansion of CAG repeats in HTT gene. The transcribed mutant RNA contains expanded CAG repeats that translate into a mutant huntingtin protein. This expanded CAG repeat also causes mis-splicing of pre-mRNA due to sequestration of muscle blind like-1 splicing factor (MBNL1) and thus both of these elicits the pathogenesis of HD. Targeting the onset as well as progression of HD by small molecules could be a potent therapeutic approach...
November 27, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/29164994/stat3-inhibition-as-a-therapeutic-strategy-for-leukemia
#8
Rubashruti Kanna, Gaurav Choudhary, Nandini Ramachandra, Ulrich Steidl, Amit Verma, Aditi Shastri
Leukemia is characterized by selective overgrowth of malignant hematopoietic stem cells (HSC's) that interfere with HSC differentiation. Cytoreductive chemotherapy can kill rapidly dividing cancerous cells but cannot eradicate the malignant HSC pool leading to relapses. Leukemic stem cells have several dysregulated pathways and the Janus kinases (JAKs) and signal transducer and activator of transcription (STAT) pathway are prominent among them. STAT3 is an important transcription factor that regulates cell growth, proliferation, and inhibits apoptosis...
November 22, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/29149224/correction-evaluation-of-acute-toxicity-and-early-clinical-outcome-in-head-and-neck-cancers-treated-with-conventional-radiotherapy-and-simultaneous-integrated-boost-arc-radiotherapy
#9
Amit Bahl, Arun S Oinam, Satinder Kaur, Roshan Verma, Arun Elangovan, Sudhir Bhandari, Jaimanti Bakshi, Naresh Panda, Sushmita Ghoshal
[This corrects the article DOI: 10.14740/wjon1049w.].
October 2017: World Journal of Oncology
https://www.readbyqxmd.com/read/29147446/evaluation-of-acute-toxicity-and-early-clinical-outcome-in-head-and-neck-cancers-treated-with-conventional-radiotherapy-and-simultaneous-integrated-boost-arc-radiotherapy
#10
Amit Bahl, Arun S Oinam, Satinder Kaur, Roshan Verma, Arun Elangovan, Sudhir Bhandari, Jaimanti Bakshi, Naresh Panda, Sushmita Ghoshal
Background: Chemoradiotherapy plays an important role in management of locally advanced head and neck cancers. This retrospective analysis was done to evaluate and compare acute toxicity profiles and early clinical outcomes in patients treated with conventional and arc techniques. Methods: Fifty-five patients of head and neck cancers were evaluated. Thirty patients received conventional radiotherapy with 6 MV or cobalt 60 and 25 patients were treated with simultaneous integrated boost-volumetric modulated arc radiotherapy (SIB-VMAT) with dose prescription of 66 - 70 Gy...
August 2017: World Journal of Oncology
https://www.readbyqxmd.com/read/29112921/a-novel-fungal-arsenic-methyltransferase-waarsm-reduces-grain-arsenic-accumulation-in-transgenic-rice-oryza-sativa-l
#11
Shikha Verma, Pankaj Kumar Verma, Alok Kumar Meher, Amit Kumar Bansiwal, Rudra Deo Tripathi, Debasis Chakrabarty
Rice (Oryza sativa L.) grown on arsenic-containing soil and water become a primary dietary source of arsenic and pose a significant health risk. Gene modification is an important and practical approach to reduce arsenic accumulation in rice grains. Here, we reported a WaarsM gene of soil fungus Westerdykella aurantiaca, expressed in rice able to convert toxic inorganic arsenicals to methylated arsenic species, therefore, reduce arsenic accumulation in rice grains. In response to arsenic treatment in hydroponics, WaarsM expressing transgenic lines showed a marked increase in arsenic resistance and reduces its accumulation compared to NT...
October 28, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29108238/sites-of-extranodal-involvement-are-prognostic-in-patients-with-stage-1-follicular-lymphoma
#12
Aditi Shastri, Murali Janakiram, Ioannis Mantzaris, Yiting Yu, Jaime S Londono, Amit K Verma, Stefan K Barta
Objectives: Follicular lymphoma (FL) is the most common indolent B cell lymphoma in the United States and a quarter of patients present with stage I disease. The objective of this study was to examine if primary site of disease influences survival in early stage lymphoma. Results: The most common extranodal primary sites were the integumentary system (8%), followed by the GI tract (6.4%) and head & neck (5.6%). We stratified patients into a pre-rituximab era (1983-1998) and the rituximab era (1999-2011)...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29097284/mechanism-of-radioprotection-by-dihydroxy-1-selenolane-dhs-effect-of-fatty-acid-conjugation-and-role-of-glutathione-peroxidase-gpx
#13
Prachi Verma, Amit Kunwar, Kenta Arai, Michio Iwaoka, K Indira Priyadarsini
Dihydroxy-1-selenolane (DHS) previously reported to exhibit radioprotective activity was investigated to understand its mechanism of action in CHO cells of epithelial origin. DHS pre-treatment at 25 μM for 16 h significantly protected CHO cells from radiation (4-11 Gy)-induced delayed mitotic cell death. Further to examine, how increased cellular uptake can influence this mechanism, studies have been performed with DHS-C6, a lipophilic conjugate of DHS. Accordingly CHO cells pre-treated with DHS-C6, showed increased survival against radiation exposure...
October 30, 2017: Biochimie
https://www.readbyqxmd.com/read/29083320/pharmacological-inhibition-of-the-transcription-factor-pu-1-in-leukemia
#14
Iléana Antony-Debré, Ananya Paul, Joana Leite, Kelly Mitchell, Hye Mi Kim, Luis A Carvajal, Tihomira I Todorova, Kenneth Huang, Arvind Kumar, Abdelbasset A Farahat, Boris Bartholdy, Swathi-Rao Narayanagari, Jiahao Chen, Alberto Ambesi-Impiombato, Adolfo A Ferrando, Ioannis Mantzaris, Evripidis Gavathiotis, Amit Verma, Britta Will, David W Boykin, W David Wilson, Gregory Mk Poon, Ulrich Steidl
The transcription factor PU.1 is often impaired in patients with acute myeloid leukemia (AML). Here, we used AML cells that already had low PU.1 levels and further inhibited PU.1 using either RNA interference or, to our knowledge, first-in-class small-molecule inhibitors of PU.1 that we developed specifically to allosterically interfere with PU.1-chromatin binding through interaction with the DNA minor groove that flanks PU.1-binding motifs. These small molecules of the heterocyclic diamidine family disrupted the interaction of PU...
October 30, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29017059/direct-activation-of-bax-by-btsa1-overcomes-apoptosis-resistance-in-acute-myeloid-leukemia
#15
Denis E Reyna, Thomas P Garner, Andrea Lopez, Felix Kopp, Gaurav S Choudhary, Ashwin Sridharan, Swathi-Rao Narayanagari, Kelly Mitchell, Baoxia Dong, Boris A Bartholdy, Loren D Walensky, Amit Verma, Ulrich Steidl, Evripidis Gavathiotis
The BCL-2 family protein BAX is a central mediator of apoptosis. Overexpression of anti-apoptotic BCL-2 proteins contributes to tumor development and resistance to therapy by suppressing BAX and its activators. We report the discovery of BTSA1, a pharmacologically optimized BAX activator that binds with high affinity and specificity to the N-terminal activation site and induces conformational changes to BAX leading to BAX-mediated apoptosis. BTSA1-induced BAX activation effectively promotes apoptosis in leukemia cell lines and patient samples while sparing healthy cells...
October 9, 2017: Cancer Cell
https://www.readbyqxmd.com/read/28986391/altered-hydroxymethylation-is-seen-at-regulatory-regions-in-pancreatic-cancer-and-regulates-oncogenic-pathways
#16
Sanchari Bhattacharyya, Kith Pradhan, Nathaniel Campbell, Jozef Mazdo, Aparna Vasantkumar, Shahina Maqbool, Tushar D Bhagat, Sonal Gupta, Masako Suzuki, Yiting Yu, John M Greally, Ulrich Steidl, James Bradner, Meelad Dawlaty, Lucy Godley, Anirban Maitra, Amit Verma
Transcriptional deregulation of oncogenic pathways is a hallmark of cancer and can be due to epigenetic alterations. 5-Hydroxymethylcytosine (5-hmC) is an epigenetic modification that has not been studied in pancreatic cancer. Genome-wide analysis of 5-hmC-enriched loci with hmC-seal was conducted in a cohort of low-passage pancreatic cancer cell lines, primary patient-derived xenografts, and pancreatic controls and revealed strikingly altered patterns in neoplastic tissues. Differentially hydroxymethylated regions preferentially affected known regulatory regions of the genome, specifically overlapping with known H3K4me1 enhancers...
November 2017: Genome Research
https://www.readbyqxmd.com/read/28970655/liraglutide-as-an-alternative-to-insulin-for-glycemic-control-in-intensive-care-unit-a-randomized-open-label-clinical-study
#17
Vishesh Verma, Narendra Kotwal, Vimal Upreti, Monish Nakra, Yashpal Singh, K Anand Shankar, Amit Nachankar, K V S Hari Kumar
BACKGROUND: Intravenous insulin is the cornerstone in the management of hyperglycemia in the Intensive Care Unit (ICU). We studied the efficacy of liraglutide compared with insulin in the ICU. MATERIALS AND METHODS: In this prospective, open-labeled, randomized study, we included 120 patients (15-65 years, either sex) admitted to ICU with capillary blood glucose (CBG) between 181 and 300 mg/dl. We excluded patients with secondary diabetes and APACHE score >24...
September 2017: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/28941070/non-aqueous-primary-li-air-flow-battery-and-optimization-of-its-cathode-through-experiment-and-modeling
#18
Byoungsu Kim, Kensuke Takechi, Sichao Ma, Sumit Verma, Shiqi Fu, Amit Desai, Ashtamurthy S Pawate, Fuminori Mizuno, Paul J A Kenis
A primary Li-air battery has been developed with a flowing Li-ion free ionic liquid as the recyclable electrolyte, boosting power capability by promoting superoxide diffusion and enhancing discharge capacity through separately stored discharge products. Experimental and computational tools are used to analyze the cathode properties, leading to a set of parameters that improve the discharge current density of the non-aqueous Li-air flow battery. The structure and configuration of the cathode gas diffusion layers (GDLs) are systematically modified by using different levels of hot pressing and the presence or absence of a microporous layer (MPL)...
September 22, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28867601/hydralazine-vs-nifedipine-for-acute-hypertensive-emergency-in-pregnancy-a-randomized-controlled-trial
#19
Chanderdeep Sharma, Anjali Soni, Amit Gupta, Ashok Verma, Suresh Verma
BACKGROUND: There is a paucity of good quality evidence regarding the best therapeutic option for acute control of blood pressure during acute hypertensive emergency of pregnancy. OBJECTIVE: We sought to compare the efficacy of intravenously administered hydralazine and oral nifedipine for acute blood pressure control in acute hypertensive emergency of pregnancy. STUDY DESIGN: In this double-blind, randomized, controlled trial, pregnant women (≥24 weeks period of gestation) with sustained increase in systolic blood pressure of ≥160 mm Hg or diastolic blood pressure of ≥110 mm Hg were randomized to receive intravenous hydralazine injection in doses of 5, 10, 10, and 10 mg and a placebo tablet or oral nifedipine (10 mg tablet up to 4 doses) and intravenous saline injection every 20 minutes until the target blood pressure of 150 mm Hg systolic and ≤100 mm Hg diastolic was achieved...
September 1, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28862641/the-u2af1s34f-mutation-induces-lineage-specific-splicing-alterations-in-myelodysplastic-syndromes
#20
Bon Ham Yip, Violetta Steeples, Emmanouela Repapi, Richard N Armstrong, Miriam Llorian, Swagata Roy, Jacqueline Shaw, Hamid Dolatshad, Stephen Taylor, Amit Verma, Matthias Bartenstein, Paresh Vyas, Nicholas Cp Cross, Luca Malcovati, Mario Cazzola, Eva Hellström-Lindberg, Seishi Ogawa, Christopher Wj Smith, Andrea Pellagatti, Jacqueline Boultwood
No abstract text is available yet for this article.
September 1, 2017: Journal of Clinical Investigation
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