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https://www.readbyqxmd.com/read/28867601/hydralazine-vs-nifedipine-for-acute-hypertensive-emergency-in-pregnancy-a-randomized-controlled-trial
#1
Chanderdeep Sharma, Anjali Soni, Amit Gupta, Ashok Verma, Suresh Verma
OBJECTIVE: We sought to compare the efficacy of intravenously administered hydralazine and oral nifedipine for acute blood pressure control in acute hypertensive emergency of pregnancy. STUDY DESIGN: In this double-blind, randomized, controlled trial, pregnant women (≥24 weeks POG) with sustained increase in systolic blood pressure of ≥160 mm Hg or diastolic blood pressure of ≥110 mm Hg were randomized to receive intravenous hydralazine injection in doses of 5, 10, 10, and 10 mg and a placebo tablet or oral nifedipine (10 mg tablet up to 4 doses) and intravenous saline injection every 20 minutes until the target blood pressure of 150 mm Hg systolic and ≤100 mm Hg diastolic was achieved...
September 1, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28862641/the-u2af1s34f-mutation-induces-lineage-specific-splicing-alterations-in-myelodysplastic-syndromes
#2
Bon Ham Yip, Violetta Steeples, Emmanouela Repapi, Richard N Armstrong, Miriam Llorian, Swagata Roy, Jacqueline Shaw, Hamid Dolatshad, Stephen Taylor, Amit Verma, Matthias Bartenstein, Paresh Vyas, Nicholas Cp Cross, Luca Malcovati, Mario Cazzola, Eva Hellström-Lindberg, Seishi Ogawa, Christopher Wj Smith, Andrea Pellagatti, Jacqueline Boultwood
No abstract text is available yet for this article.
September 1, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28831704/first-report-of-molecular-characterization-and-phylogenetic-analysis-of-rotat-1-2-vsg-of-trypanosoma-evansi-from-equine-isolate
#3
Vikrant Sudan, Amit Kumar Jaiswal, Daya Shanker, Amit Kumar Verma
Rotat 1.2 variant surface glycoprotein (VSG) is considered to be an important VSG expressed in most of the isolates of Trypanosoma evansi. This makes the molecule an important candidate for both molecular- and serological-based detection of surra. There are ample reports of existence of this gene in isolates from cattle, buffalo, and camel across the world. Of late, there are reports of its absence from a fewer isolates of T. evansi of murine and wildlife origin. Search of literature revealed no reports from horses...
August 22, 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/28831610/microbial-taxonomy-in-the-era-of-omics-application-of-dna-sequences-computational-tools-and-techniques
#4
Nitish Kumar Mahato, Vipin Gupta, Priya Singh, Rashmi Kumari, Helianthous Verma, Charu Tripathi, Pooja Rani, Anukriti Sharma, Nirjara Singhvi, Utkarsh Sood, Princy Hira, Puneet Kohli, Namita Nayyar, Akshita Puri, Abhay Bajaj, Roshan Kumar, Vivek Negi, Chandni Talwar, Himani Khurana, Shekhar Nagar, Monika Sharma, Harshita Mishra, Amit Kumar Singh, Gauri Dhingra, Ram Krishan Negi, Mallikarjun Shakarad, Yogendra Singh, Rup Lal
The current prokaryotic taxonomy classifies phenotypically and genotypically diverse microorganisms using a polyphasic approach. With advances in the next-generation sequencing technologies and computational tools for analysis of genomes, the traditional polyphasic method is complemented with genomic data to delineate and classify bacterial genera and species as an alternative to cumbersome and error-prone laboratory tests. This review discusses the applications of sequence-based tools and techniques for bacterial classification and provides a scheme for more robust and reproducible bacterial classification based on genomic data...
August 22, 2017: Antonie Van Leeuwenhoek
https://www.readbyqxmd.com/read/28801562/explosive-death-induced-by-mean-field-diffusion-in-identical-oscillators
#5
Umesh Kumar Verma, Amit Sharma, Neeraj Kumar Kamal, Jürgen Kurths, Manish Dev Shrimali
We report the occurrence of an explosive death transition for the first time in an ensemble of identical limit cycle and chaotic oscillators coupled via mean-field diffusion. In both systems, the variation of the normalized amplitude with the coupling strength exhibits an abrupt and irreversible transition to death state from an oscillatory state and this first order phase transition to death state is independent of the size of the system. This transition is quite general and has been found in all the coupled systems where in-phase oscillations co-exist with a coupling dependent homogeneous steady state...
August 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28717762/epidermal-growth-factor-receptor-mutational-status-and-brain-metastases-in-non-small-cell-lung-cancer
#6
Vijaya Raj Bhatt, Sanyo P D'Souza, Lynette M Smith, Allison M Cushman-Vokoun, Vanita Noronha, Vivek Verma, Amit Joshi, Anuradha Chougule, Nirmala Jambhekar, Anne Kessinger, Alissa Marr, Vijay Patil, Sripad D Banavali, Apar Kishor Ganti, Kumar Prabhash
INTRODUCTION: Epidermal growth factor receptor (EGFR) mutations in non-small-cell lung cancers (NSCLC) may be more common in patients with brain metastases. Previous studies, however, did not adjust for effects of confounding variables. METHODS: This retrospective study included 1,522 consecutive patients with NSCLC, whose tumors were diagnosed and tested for EGFR mutations at the University of Nebraska Medical Center (Omaha, NE) and Tata Memorial Hospital (Mumbai, India)...
June 2017: Journal of Global Oncology
https://www.readbyqxmd.com/read/28714383/novel-mannich-bases-as-potential-anticonvulsants-syntheses-characterization-and-biological-evaluation
#7
Amit Kumar Keshari, Aseem Tewari, Shweta Singh Verma, Shailendra K Saraf
BACKGROUND: Mannich bases are known to be an important pharmacophore or bioactive leads in the synthesis of various potential agents that have a variety of therapeutic activities like anticancer, antipsychotic, anticonvulsant, antimalarial, anti-inflammatory, antibacterial and so forth. Thus, in the present research, conjugation of moieties like 1,5-benzoxazepines and 1,5-benzothiazepines with secondary amines like piperazine, methyl piperazine and morpholine was carried out in a Mannich base with an anticipation of good anticonvulsant activity...
July 17, 2017: Central Nervous System Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/28708503/effect-of-dietary-supplementation-of-omega-3-polyunsaturated-fatty-acid-pufa-rich-fish-oil-on-reproductive-performance-of-the-goat-capra-hircus
#8
Ajit Singh Mahla, Ravjibhai K Chaudhari, Atul Kumar Verma, Amit Kumar Singh, Sanjay Kumar Singh, Gyanendra Singh, Mihir Sarkar, Narayan Dutta, Harendra Kumar, Narayanan Krishnaswamy
Dietary supplementation of n-3 PUFA decreases the luteolytic PGF2α and improves the pregnancy rate in the dairy cow. However, its effect in the goat is not known. Accordingly, we studied the effect of supplementation of n-3 PUFA rich Fish oil (FO) on different reproductive events in the goat. Cycling goats (n = 30) were divided into two equal groups and fed an isocaloric and isonitrogenous diet supplemented with either FO (TRT; n = 15) or palm oil (PO) (CON; n = 15) @ 0.6 mL/kg body weight for 72 days during the breeding season...
May 26, 2017: Theriogenology
https://www.readbyqxmd.com/read/28684528/epigenetically-aberrant-stroma-in-mds-propagates-disease-via-wnt-%C3%AE-catenin-activation
#9
Tushar D Bhagat, Si Chen, Matthias Bartenstein, A Trevor Barlowe, Dagny Von Ahrens, Gaurav S Choudhary, Patrick Tivnan, Elianna Amin, A Mario Marcondes, Mathijs A Sanders, Remco M Hoogenboezem, Suman Kambhampati, Nandini Ramachandra, Iaonnis Mantzaris, Vineeth Sukrithan, Remi Laurence, Robert Lopez, Prafullla Bhagat, Orsi Giricz, Davendra Sohal, Amittha Wickrema, Cecilia Yeung, Kira Gritsman, Peter Aplan, Konrad Hochedlinger, Yiting Yu, Kith Pradhan, Jinghang Zhang, John M Greally, Siddhartha Mukherjee, Andrea Pellagatti, Jacqueline Boultwood, Britta Will, Ulrich Steidl, Marc H G P Raaijmakers, H Joachim Deeg, Michael G Kharas, Amit Verma
The bone marrow microenvironment influences malignant hematopoiesis, but how it promotes leukemogenesis has not been elucidated. In addition, the role of the bone marrow stroma in regulating clinical responses to DNA methyltransferase inhibitors (DNMTi) is also poorly understood. In this study, we conducted a DNA methylome analysis of bone marrow-derived stromal cells from myelodysplastic syndrome (MDS) patients and observed widespread aberrant cytosine hypermethylation occurring preferentially outside CpG islands...
September 15, 2017: Cancer Research
https://www.readbyqxmd.com/read/28684379/pharmacokinetics-directed-intravenous-busulfan-combined-with-high-dose-melphalan-and-bortezomib-as-a-conditioning-regimen-for-patients-with-multiple-myeloma
#10
Stefan K Barta, Rishi Jain, Amithaba Mazumder, Jason Carter, Lawrence Almanzar, Roy Browne, Samira Shahnaz, Richard Elkind, David Kaminetzky, Ramakrishna Battini, Olga Derman, Noah Kornblum, Amit Verma, Ira Braunschweig
BACKGROUND: High-dose chemotherapy followed by autologous stem cell transplantation (ASCT) has a well-established role in the treatment of patients with multiple myeloma. Melphalan 200 mg/m(2) (Mel200) is the most commonly used preparative regimen. Several studies have provided evidence for potential synergism and safety when combining bortezomib (Btz) or busulfan (Bu) with melphalan (Mel). PATIENTS AND METHODS: We conducted a prospective phase II study to investigate the safety and efficacy of conditioning with pharmacokinetics (PK)-directed intravenous (IV) Bu with Btz and Mel...
June 17, 2017: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/28675459/stimulation-of-adrenergic-activity-by-desipramine-enhances-hematopoietic-stem-and-progenitor-cell-mobilization-along-with-g-csf-in-multiple-myeloma-a-pilot-study
#11
Aditi Shastri, Anjali Budhathoki, Stefan K Barta, Noah Kornblum, Olga Derman, Ramakrishna Battini, Radha Raghupathy, Amit K Verma, Paul S Frenette, Ira Braunschweig, Murali Janakiram
Hematopoietic stem cell (HSC) release is positively regulated by the sympathetic nervous system through the β3 adrenergic receptor. Preclinical studies have demonstrated that the combination of desipramine and G-CSF resulted in improved HSC mobilization. Here, we present the results of an open-label single-arm pilot study in patients with multiple myeloma undergoing autologous stem cell transplantation (ASCT) to assess the safety and efficacy of desipramine combined with G-SCF to induce HSC mobilization. The primary endpoint was safety of the combination including engraftment kinetics...
July 4, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28667647/elucidating-stress-proteins-in-rice-oryza-sativa-l-genotype-under-elevated-temperature-a-proteomic-approach-to-understand-heat-stress-response
#12
Narendra Kumar, Deep Chandra Suyal, Ishwar Prakash Sharma, Amit Verma, Hukum Singh
Rice is one of the widely consumed staple foods among the world's human population. Its production is adversely affected by high temperature and is more pronounced at flowering stage. Elucidating elevated temperature stress-related proteins as well as associated mechanisms is inevitable for improving heat tolerance in rice. In the present study, a proteomic analysis of heat-sensitive rice genotype, IET 21405 was conducted. Two-dimensional electrophoresis (2-DE) and MALDI-TOF/MS-based proteomics approaches revealed a total of 73 protein spots in rice leaf...
July 2017: 3 Biotech
https://www.readbyqxmd.com/read/28658858/clinical-outcome-of-treatment-of-diaphyseal-fractures-of-humerus-treated-by-titanium-elastic-nails-in-adult-age-group
#13
Amit Verma, Sudhir Shyam Kushwaha, Yasir Ali Khan, Farid Mohammed, Subhanshu Shekhar, Ankur Goyal
INTRODUCTION: Humerus shaft fracture is one of the most common injuries to the musculoskeletal system, which are managed both conservatively and surgically. There are pitfalls, advantages and disadvantages in each method. The individual fracture analysis determines the therapeutic options. AIM: To assess the clinical outcome of treatment of diaphyseal fractures of humerus treated by Titanium elastic nail in adult age group by DASH scoring. MATERIALS AND METHODS: It was a prospective study of 20 cases of diaphyseal fracture of humerus admitted to Era's Lucknow Medical College and Hospital between October 2014 and September 2015 treated with close reduction and internal fixation with titanium elastic nail...
May 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28636756/chemical-composition-and-allelopathic-antibacterial-antifungal-and-antiacetylcholinesterase-activity-of-fish-mint-houttuynia-cordata-thunb-from-india
#14
Ram S Verma, Neeta Joshi, Rajendra C Padalia, Ved R Singh, Prakash Goswami, Ajay Kumar, Hina Iqbal, Rajesh K Verma, Debabrata Chanda, Amit Chauhan, Dharmendra Saikia
Fish-mint (Houttuynia cordata Thunb.), belongs to family Saururaceae has long been used as food and traditional herbal medicine. The present study was framed to assess the changes occurring in the essential-oil composition of Houttuynia cordata during annual growth and to evaluate allelopathic, antibacterial, antifungal and antiacetylcholinesterase activities. The essential-oil content ranged from 0.06-0.14% and 0.08-0.16% in aerial-parts and underground-stem, respectively. The essential oils were analysed by GC-FID, GC-MS and NMR ((1) H & (13) C)...
June 21, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28624988/mifepristone-vs-balloon-catheter-for-labor-induction-in-previous-cesarean-a-randomized-controlled-trial
#15
Chanderdeep Sharma, Anjali Soni, Amit Gupta, Ashok Verma, Suresh Verma
OBJECTIVE: To compare oral mifepristone (400 mg) with trans-cervical balloon catheter for induction of labor (IOL) in post date women with previous one cesarean section (CS). METHODS: In this randomized trial, post date pregnant women (gestation 40 weeks 5 days), with previous one low segment CS (no previous vaginal delivery) were induced either with oral mifepristone (400 mg) or balloon catheter [Foley's catheter (16 Fr); bulb filled with 30 ml normal saline]...
August 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28587497/accelerated-leukemic-transformation-after-haplo-identical-transplantation-for-hydroxyurea-treated-sickle-cell-disease
#16
Murali Janakiram, Amit Verma, Yanhua Wang, Anjali Budhathoki, Jaime Suarez Londono, Irina Murakhovskaya, Ira Braunschweig, Caterina P Minniti
No abstract text is available yet for this article.
June 7, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/28585369/chemical-composition-and-antibacterial-antifungal-allelopathic-and-acetylcholinesterase-inhibitory-activities-of-cassumunar-ginger
#17
Ram S Verma, Neeta Joshi, Rajendra C Padalia, Ved R Singh, Prakash Goswami, Sajendra K Verma, Hina Iqbal, Debabrata Chanda, Rajesh K Verma, Mahendra P Darokar, Amit Chauhan, Manish K Kandwal
BACKGROUND: Zingiber montanum (J.Koenig) Link ex A.Dietr. (Zingiberaceae), commonly known as cassumunar-ginger, is a folk remedy for the treatments of inflammations, sprains, rheumatism and asthma. The aim of this study was to assess the chemical composition, and antibacterial, antifungal, allelopathic and acetylcholinesterase inhibitory activities of the essential oil of Z. montanum originated from India. RESULTS: The hydrodistilled essential oil of Z. montanum rhizome was analyzed using GC-FID and GC-MS...
June 6, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28503683/cellular-evaluation-of-diselenonicotinamide-dsna-as-a-radioprotector-against-cell-death-and-dna-damage
#18
M Raghuraman, Prachi Verma, Amit Kunwar, Prasad P Phadnis, V K Jain, K Indira Priyadarsini
Diselenonicotinamide (DSNA), a synthetic organoselenium compound, was evaluated for its radioprotective effect in cellular models. A clonogenic assay in Chinese Hamster Ovary (CHO) cells and an apoptosis assay in murine splenic lymphocytes indicated that pre-treatment with DSNA at a concentration of 25 μM significantly protected them from radiation-induced cell death. Upon irradiation (1-12 Gy), dose-response studies were carried out under similar treatment conditions, and its dose modification factor (DMF) was estimated to be 1...
June 1, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28486913/pharmacophore-3d-qsar-models-and-dynamic-simulation-of-1-4-benzothiazines-for-colorectal-cancer-treatment
#19
Amit Rai, Vinit Raj, Mohamed Hodhod Aboumanei, Ashok K Singh, Amit K Keshari, Suraj P Verma, Sudipta Saha
Interleukin-6 has become an attractive protein target. This is found in the progression of colon cancer. It performs various functions in the colon cancer cells such as inflammation, activates various cell types signaling and also promotes proliferation in colon cancer cells. It is a valid target to develop of anticolon cancer drug. The purpose of our study is to develop the Three-dimensional Quantitative Structure-Activity Relationship (3D-QSAR) models, pharmacophore modeling and docking study as well as MD simulation to find out the novel potent inhibitors that bind with Interleukin-6 in colon cancer treatment...
May 9, 2017: Combinatorial Chemistry & High Throughput Screening
https://www.readbyqxmd.com/read/28450372/evolutionary-conservation-and-emerging-functional-diversity-of-the-cytosolic-hsp70-j-protein-chaperone-network-of-arabidopsis-thaliana
#20
Amit K Verma, Danish Diwan, Sandeep Raut, Neha Dobriyal, Rebecca E Brown, Vinita Gowda, Justin K Hines, Chandan Sahi
Heat shock proteins of 70 kDa (Hsp70s) partner with structurally diverse Hsp40s (J proteins), generating distinct chaperone networks in various cellular compartments that perform myriad housekeeping and stress-associated functions in all organisms. Plants, being sessile, need to constantly maintain their cellular proteostasis in response to external environmental cues. In these situations, the Hsp70:J protein machines may play an important role in fine-tuning cellular protein quality control. Although ubiquitous, the functional specificity and complexity of the plant Hsp70:J protein network has not been studied...
June 7, 2017: G3: Genes—Genomes—Genetics
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