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https://www.readbyqxmd.com/read/28725169/postoperative-delirium-after-pharyngolaryngectomy-with-esophagectomy-a-role-for-ramelteon-and-suvorexant
#1
Eisuke Booka, Yasuhiro Tsubosa, Teruaki Matsumoto, Mari Takeuchi, Takashi Kitani, Masato Nagaoka, Atsushi Imai, Tomoyuki Kamijo, Yoshiyuki Iida, Ayako Shimada, Katsushi Takebayashi, Masahiro Niihara, Keita Mori, Tetsuro Onitsuka, Hiroya Takeuchi, Yuko Kitagawa
BACKGROUND: Postoperative delirium is common after extensive surgery, and is known to be associated with sleeping medications. In this study, we aimed to investigate the relationships between sleeping medications and postoperative delirium after pharyngolaryngectomy with esophagectomy. METHODS: We performed a retrospective analysis of 65 patients who underwent pharyngolaryngectomy with esophagectomy at Shizuoka Cancer Center Hospital between January 2012 and March 2016...
2017: Esophagus: Official Journal of the Japan Esophageal Society
https://www.readbyqxmd.com/read/28662460/efficacy-and-safety-of-sublingual-ramelteon-as-an-adjunctive-therapy-in-the-maintenance-treatment-of-bipolar-i-disorder-in-adults-a-phase-3-randomized-controlled-trial
#2
Atul R Mahableshwarkar, Joseph R Calabrese, Thomas A Macek, Kumar Budur, Adedeji Adefuye, Xinxin Dong, Elizabeth Hanson, Gary S Sachs
BACKGROUND: The optimal long-term management strategy for bipolar I disorder patients is not yet established. Evidence supports the rationale for circadian rhythm regulation to prevent mood episode relapse in bipolar patients. This study evaluated the efficacy and safety of a new sublingual formulation of the melatonin receptor agonist ramelteon (ramelteon SL) as adjunctive therapy in the maintenance treatment of bipolar I patients. METHODS: In a double-blinded trial in the United States and Latin America, adult bipolar I disorder patients stable for ≥ 8 weeks before baseline and with a mood episode 8 weeks to 9 months before screening, were randomized to once-daily ramelteon SL 0...
October 15, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28627372/regulatory-role-of-melatonin-and-bmp-4-in-prolactin-production-by-rat-pituitary-lactotrope-gh3-cells
#3
Kanako Ogura-Ochi, Satoshi Fujisawa, Nahoko Iwata, Motoshi Komatsubara, Yuki Nishiyama, Naoko Tsukamoto-Yamauchi, Kenichi Inagaki, Jun Wada, Fumio Otsuka
The effects of melatonin on prolactin production and its regulatory mechanism remain uncertain. We investigated the regulatory role of melatonin in prolactin production using rat pituitary lactotrope GH3 cells by focusing on the bone morphogenetic protein (BMP) system. Melatonin receptor activation, induced by melatonin and its receptor agonist ramelteon, significantly suppressed basal and forskolin-induced prolactin secretion and prolactin mRNA expression in GH3 cells. The melatonin MT2 receptor was predominantly expressed in GH3 cells, and the inhibitory effects of melatonin on prolactin production were reversed by treatment with the receptor antagonist luzindole, suggesting functional involvement of MT2 action in the suppression of prolactin release...
June 13, 2017: Peptides
https://www.readbyqxmd.com/read/28579782/effect-of-aripiprazole-on-non-24-hour-sleep-wake-rhythm-disorder-comorbid-with-major-depressive-disorder-a-case-report
#4
Kentaro Matsui, Yoshikazu Takaesu, Takeshi Inoue, Ken Inada, Katsuji Nishimura
BACKGROUND: Patients with non-24-hour sleep-wake rhythm disorder (N24SWD) exhibit a sleep pattern that is asynchronous with the external light-dark cycle, typically involving a cycling, relapsing-remitting pattern of sleep disturbances, including nighttime insomnia and daytime sleepiness. Here, we report the case of a patient with N24SWD comorbid with major depressive disorder, who was successfully treated with a low dose of aripiprazole. CASE PRESENTATION: A 47-year-old female presented with an 8-year complaint of difficulty falling asleep and waking up in the morning...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28516430/ramelteon-improves-post-traumatic-stress-disorder-like-behaviors-exhibited-by-fatty-acid-binding-protein-3-null-mice
#5
Yasushi Yabuki, Ibuki Takahata, Kazuya Matsuo, Yuji Owada, Kohji Fukunaga
We previously reported that fatty acid-binding protein 3 (FABP3) knockout (Fabp3 (-/-)) mice exhibit abnormal dopamine-related behaviors such as enhanced dopamine D2 receptor antagonist-induced catalepsy behaviors. Here, we report that Fabp3 null mice exhibit cognitive deficits, hyperlocomotion and impaired fear extinction, and thus show post-traumatic stress disorder (PTSD)-like behaviors. Notably, chronic administration of ramelteon (1.0 mg/kg, p.o.), a melatonin receptor agonist, improved all PTSD-like behaviors tested in Fabp3 (-/-) mice...
May 17, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28508438/the-effect-of-chronotherapy-on-delirium-in-critical-care%C3%A2-%C3%A2-a-systematic-review
#6
Roseanne Luther, Anne McLeod
BACKGROUND: Delirium is highly prevalent within critical care and is linked to adverse clinical outcomes, increased mortality and impaired quality of life. Development of delirium is thought to be caused by multiple risk factors, including disruption of the circadian rhythm. Chronotherapeutic interventions, such as light therapy, music and use of eye shades, have been suggested as an option to improve circadian rhythm within intensive care units. AIM: This review aims to answer the question: Can chronotherapy reduce the prevalence of delirium in adult patients in critical care? DESIGN: This study is a systematic review of quantitative studies...
May 15, 2017: Nursing in Critical Care
https://www.readbyqxmd.com/read/28382516/ramelteon-a-selective-mt1-mt2-receptor-agonist-suppresses-the-proliferation-and-invasiveness-of-endometrial-cancer-cells
#7
Kiyono Osanai, Yoichi Kobayashi, Masahiro Otsu, Tomoko Izawa, Keiji Sakai, Mitsutoshi Iwashita
The incidence of endometrial cancer is increasing, making it the fifth most common cancer worldwide. To date, however, there is no standard therapy for patients with recurrent endometrial cancer. Melatonin, a hormone secreted by the pineal gland, has been shown to have anti-tumor effects in various tumor types. Although melatonin is available as a supplement, it has not been approved for cancer treatment. Ramelteon, a selective melatonin receptor type 1 and 2 (MT1/MT2) receptor agonist, has been approved to treat sleep disorders, suggesting that ramelteon may be effective in the treatment of endometrial cancer...
July 2017: Human Cell
https://www.readbyqxmd.com/read/28270270/a-review-of-suvorexant-doxepin-ramelteon-and-tasimelteon-for-the-treatment-of-insomnia-in-geriatric-patients
#8
REVIEW
Chelsey Edmonds, Michael Swanoski
Geriatric patients often experience insomnia because of physiological and neurological changes that occur during the aging process. Use of benzodiazepines, nonbenzodiazepine hypnotics, and diphenhydramine for the treatment of insomnia pose an increased risk of cognitive impairment, falls, and fractures in this patient population. Therapeutic alternatives approved by the Food and Drug Administration include suvorexant, doxepin, ramelteon, and tasimelteon, which have shown efficacy and safety in various studies...
March 1, 2017: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
https://www.readbyqxmd.com/read/28075519/an-update-of-management-of-insomnia-in-patients-with-chronic-orofacial-pain
#9
REVIEW
Galit Almoznino, Yaron Haviv, Yair Sharav, Rafael Benoliel
In this review we discuss the management of chronic orofacial pain (COFP) patients with insomnia. Diagnostic work-up and follow-up routines of COFP patients should include assessment of sleep problems. Management is based on a multidisciplinary approach, addressing the factors that modulate the pain experience as well as insomnia and including both non-pharmacological and pharmacological modalities. Parallel to treatment, patients should receive therapy for co-morbid medical and psychiatric disorders, and possible substance abuse that may be that may trigger or worsen the COFP and/or their insomnia...
January 11, 2017: Oral Diseases
https://www.readbyqxmd.com/read/27851868/pharmacotherapies-for-sleep-disturbances-in-dementia
#10
REVIEW
Jenny McCleery, Daniel A Cohen, Ann L Sharpley
BACKGROUND: Sleep disturbances, including reduced nocturnal sleep time, sleep fragmentation, nocturnal wandering, and daytime sleepiness are common clinical problems in dementia, and are associated with significant caregiver distress, increased healthcare costs, and institutionalisation. Drug treatment is often sought to alleviate these problems, but there is significant uncertainty about the efficacy and adverse effects of the various hypnotic drugs in this vulnerable population. OBJECTIVES: To assess the effects, including common adverse effects, of any drug treatment versus placebo for sleep disorders in people with dementia, through identification and analysis of all relevant randomised controlled trials (RCTs)...
November 16, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27832188/melatonin-receptor-agonists-as-the-perioceutics-agents-for-periodontal-disease-through-modulation-of-porphyromonas-gingivalis-virulence-and-inflammatory-response
#11
Wei Zhou, Xuan Zhang, Cai-Lian Zhu, Zhi-Yan He, Jing-Ping Liang, Zhong-Chen Song
AIM: "Perioceutics" including antimicrobial therapy and host modulatory therapy has emerged as a vital adjunctive treatment of periodontal disease. Melatonin level was significantly reduced in patients with periodontal diseases suggesting melatonin could be applied as a potential "perioceutics" treatment of periodontal diseases. This study aims to investigate the effects of melatonin receptor agonists (melatonin and ramelteon) on Porphyromonas gingivalis virulence and Porphyromonas gingivalis-derived lipopolysaccharide (Pg-LPS)-induced inflammation...
2016: PloS One
https://www.readbyqxmd.com/read/27829954/the-effects-of-ramelteon-on-glucose-metabolism-and-sleep-quality-in-type-2-diabetic-patients-with-insomnia-a-pilot-prospective-randomized-controlled-trial
#12
Tetsuji Tsunoda, Masayo Yamada, Tomoaki Akiyama, Taichi Minami, Taishi Yoshii, Yoshinobu Kondo, Shinobu Satoh, Yasuo Terauchi
BACKGROUND: Insomnia is associated with the onset and development of diabetes. Melatonin affects sleep quality and glucose metabolism in diabetic patients with insomnia. We administered ramelteon, an agonist of melatonin, to type 2 diabetic patients and investigated its effects on glucose metabolism and insomnia. METHODS: This multicenter, prospective, randomized, and observational pilot study was performed between April 2014 and April 2015 at three institutes in Japan...
December 2016: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/27776398/the-relief-effects-of-ramelteon-on-refractory-chronic-migraine-a-case-report
#13
Yi-Cheng Hou, Chien-Han Lai
The selective melatonin receptor agonism effect of ramelteon is useful for insomnia. Here we wanted to present a refractory chronic migraine case, who had significant improvements in migraine after using ramelteon. The possible mechanism for the ramelteon in the migraine relief might be related to melatonin effects.
November 30, 2016: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27754030/yia-03-06-ramelteon-attenuates-cardiac-injury-improves-insulin-signaling-in-white-adipose-tissue-and-attenuates-whitening-of-brown-adipose-tissue-in-rats-with-metabolic-syndrome
#14
Ayako Uchinaka, Yuri Kawashima, Yuki Sano, Mamoru Yoneda, Shogo Ito, Yusuke Sano, Kai Nagasawa, Natsumi Matsuura, Yuichiro Yamada, Toyoaki Murohara, Kohzo Nagata
OBJECTIVE: The pineal hormone melatonin, which regulates the body's circadian rhythm, possesses anti-oxidative and anti-inflammatory effects and thereby improves metabolic disorders. Ramelteon is a potent and highly selective agonist of melatonin receptors and attenuates age-associated hypertension and body weight gain in spontaneously hypertensive rats. However, the effects of ramelteon on cardiovascular and metabolic disorders in metabolic syndrome (MetS) remain unclear. We investigated the effects of ramelteon on cardiac and adipose tissue pathology in a rat model of MetS...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27752878/treatment-of-rem-sleep-behavior-disorder
#15
REVIEW
Youngsin Jung, Erik K St Louis
REM sleep behavior disorder (RBD) is a common parasomnia disorder affecting between 1 and 7 % of community-dwelling adults, most frequently older adults. RBD is characterized by nocturnal complex motor behavior and polysomnographic REM sleep without atonia. RBD is strongly associated with synucleinopathy neurodegeneration. The approach to RBD management is currently twofold: symptomatic treatment to prevent injury and prognostic counseling and longitudinal follow-up surveillance for phenoconversion toward overt neurodegenerative disorders...
November 2016: Current Treatment Options in Neurology
https://www.readbyqxmd.com/read/27751669/review-of-safety-and-efficacy-of-sleep-medicines-in-older-adults
#16
REVIEW
Jennifer L Schroeck, James Ford, Erin L Conway, Kari E Kurtzhalts, Megan E Gee, Krista A Vollmer, Kari A Mergenhagen
PURPOSE: Insomnia is problematic for older adults. After behavioral modifications fail to show adequate response, pharmacologic options are used. The pharmacokinetics of agents used to treat insomnia may be altered. This review focuses on the safety and efficacy of medications used to treat insomnia. METHODS: A literature search of Medline, PubMed, and Embase was conducted (January 1966-June 2016). It included systematic reviews, randomized controlled trials, observational studies, and case series that had an emphasis on insomnia in an older population...
November 2016: Clinical Therapeutics
https://www.readbyqxmd.com/read/27642948/yia-03-06-ramelteon-attenuates-cardiac-injury-improves-insulin-signaling-in-white-adipose-tissue-and-attenuates-whitening-of-brown-adipose-tissue-in-rats-with-metabolic-syndrome
#17
Ayako Uchinaka, Yuri Kawashima, Yuki Sano, Mamoru Yoneda, Shogo Ito, Yusuke Sano, Kai Nagasawa, Natsumi Matsuura, Yuichiro Yamada, Toyoaki Murohara, Kohzo Nagata
OBJECTIVE: The pineal hormone melatonin, which regulates the body's circadian rhythm, possesses anti-oxidative and anti-inflammatory effects and thereby improves metabolic disorders. Ramelteon is a potent and highly selective agonist of melatonin receptors and attenuates age-associated hypertension and body weight gain in spontaneously hypertensive rats. However, the effects of ramelteon on cardiovascular and metabolic disorders in metabolic syndrome (MetS) remain unclear. We investigated the effects of ramelteon on cardiac and adipose tissue pathology in a rat model of MetS...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27624354/efficacy-of-ramelteon-for-delirium-after-lung-cancer-surgery
#18
Ryo Miyata, Mitsugu Omasa, Ryo Fujimoto, Hiroyuki Ishikawa, Minoru Aoki
OBJECTIVES: The aim of the study was to evaluate the feasibility of Ramelteon for the prevention of delirium after lung cancer surgery in elderly patients. METHODS: Medical records of patients over 70 years old, who underwent anatomical pulmonary resection for lung cancer at our institution from January 2013 to December 2015, were reviewed. Patients treated in 2013 and 2014 were used as a control group. Ramelteon was administered daily for 7 days after surgery. The incidence of delirium was determined based on the Intensive Care Delirium Screening Checklist (ICDSC)...
January 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/27580554/a-cluster-headache-responsive-to-ramelteon-a-selective-melatonin-mt1-mt2-receptor-agonist
#19
Noboru Imai
Patients with cluster headaches occasionally fail to respond to conventional preventive treatments. We herein report a case of a patient with a cluster headache in which the symptoms were refractory to conventional preventive treatments except for high-dose glucocorticoids. The headache attacks occurred daily while sleeping, thus the patient suffered from insomnia. Ramelteon, a selective melatonin receptor agonist and a member of a new class of insomnia therapies, completely suppressed the attacks during sleep and provided rapid relief from insomnia...
2016: Internal Medicine
https://www.readbyqxmd.com/read/27551178/a-review-of-melatonin-its-receptors-and-drugs
#20
REVIEW
Mucahit Emet, Halil Ozcan, Lutfu Ozel, Muhammed Yayla, Zekai Halici, Ahmet Hacimuftuoglu
After a Turkish scientist took Nobel Prize due to his contributions to understand clock genes, melatonin, closely related to these genes, may begin to shine. Melatonin, a hormone secreted from the pineal gland at night, plays roles in regulating sleep-wake cycle, pubertal development and seasonal adaptation. Melatonin has antinociceptive, antidepressant, anxiolytic, antineophobic, locomotor activity-regulating, neuroprotective, anti-inflammatory, pain-modulating, blood pressure-reducing, retinal, vascular, anti-tumor and antioxidant effects...
June 2016: Eurasian Journal of Medicine
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