Xin Zhang, Xiulin Lin, Hui Luo, Yuanxing Zhi, Xin Yi, Xiaoyan Wu, Wendi Duan, Ying Cao, Jianxin Pang, Shuwen Liu, Pingzheng Zhou
Emerging data have demonstrated the critical roles of potassium efflux in the innate immune system. However, the role of potassium efflux in TLR3/4 activation and type I interferon (IFN) responses are not well elucidated. In the present study, we found potassium efflux is essential for TLR3/4 signaling, which mediates the expression of IFN and its inducible gene Cxcl10 and proinflammatory cytokine gene TNF-α. Furthermore, pharmacological inhibition of Kv1.3 channel (PAP-1), but not Kir2.1, KCa3.1 or TWIK2, attenuated TLR3/4 receptor activation in macrophages...
February 2, 2022: Pharmacological Research: the Official Journal of the Italian Pharmacological Society