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"circadian rhythm" "sleep" "dyslipidemia"

Jessica M Ferrell, John Y L Chiang
BACKGROUND & AIMS: Bile acids are physiological detergents that also activate nuclear receptors to regulate glucose and lipid homeostasis. Cholesterol 7α-hydroxylase (Cyp7a1), the rate-limiting enzyme that converts cholesterol to bile acids, is transcriptionally regulated by bile acids and circadian rhythms. Fasting, nutrients and the circadian clock critically control hepatic bile acid and lipid homeostasis, while circadian misalignment is associated with metabolic syndrome in humans...
November 1, 2015: Cellular and Molecular Gastroenterology and Hepatology
Jessica M Ferrell, John Y L Chiang
Mounting research evidence demonstrates a significant negative impact of circadian disruption on human health. Shift work, chronic jet lag and sleep disturbances are associated with increased incidence of metabolic syndrome, and consequently result in obesity, type 2 diabetes and dyslipidemia. Here, these associations are reviewed with respect to liver metabolism and disease.
March 2015: Acta Pharmaceutica Sinica. B
M S Uddin, M I Hoque, M K Uddin, S A Kamol, R H Chowdhury
Stroke is a leading cause of death and disability worldwide. While the immediate consequence of stroke include permanent cognitive deficits, paralysis, visual impairment and sensory disturbances; stroke also results in long term dysregulation of sleep and mood, which may be equally disabling. The influence of ischemic stroke on circadian rhythm regulation, which is strongly linked to sleep and mood, may thus potentially influence long term recovery in stroke patients. Stroke induces immediate changes in the timing of pineal melatonin secretion, indicating that cortical and basal ganglia infarction impacts the timing of melatonin rhythms...
January 2015: Mymensingh Medical Journal: MMJ
Yuri Kawabe, Yasuyuki Nakamura, Sayuri Kikuchi, Yoshitaka Murakami, Taichiro Tanaka, Toru Takebayashi, Akira Okayama, Katsuyuki Miura, Tomonori Okamura, Hirotsugu Ueshima
AIM: To examine the relationship between the type of work and the number of metabolic syndrome diagnostic components(MetS-DC), as well as the risk of MetS, with adjustment for lifestyle habits in Japanese workers. METHODS: We examined the baseline data from 4,427 participants(81.4% male) aged 19 to 69 years old. The physical activity of each participant was classified according to the International Physical Activity Questionnaire(IPAQ). We defined the four MetS-DC in this study as follows: 1) high blood pressure(BP): systolic BP ≥130 mmHg, or diastolic BP ≥85 mmHg, or the use of antihypertensive drugs; 2) dyslipidemia: high-density lipoprotein-cholesterol concentration <40 mg/dl or triglyceride concentration ≥150 mg/dl, or on medication for dyslipidemia; 3) dysglycemia: fasting blood sugar level ≥110 mg/dl, or if less than eight hours after meals ≥140mg/dl, or on medication for diabetes mellitus; 4) overweight: a body mass index ≥25kg/m(2)...
2014: Journal of Atherosclerosis and Thrombosis
P A Kudlow, D S Cha, R W Lam, R S McIntyre
Remarkable proportions of individuals diagnosed with major depressive disorder (MDD) have comorbid metabolic disturbances (i.e., obesity, type 2 diabetes mellitus (T2DM), hypertension, dyslipidemia), and vice versa. Accumulating evidence suggests that common pathophysiologic pathways such as a chronic, low-grade, proinflammatory state mediate this frequent co-occurrence. However, it remains unclear what traits precede the onset and increase the risk for these pathologic states. The aim of our review was to evaluate the evidentiary base supporting the hypothesis that the increased hazard for metabolic disturbance in MDD subpopulations (and vice versa) is mediated in part by endophenotypic variations in sleep architecture...
October 2013: Sleep Medicine
Wojciech Trzepizur, Marc Le Vaillant, Nicole Meslier, Thierry Pigeanne, Philippe Masson, Marie P Humeau, Acya Bizieux-Thaminy, François Goupil, Sylvaine Chollet, Pierre H Ducluzeau, Frédéric Gagnadoux
BACKGROUND: There is growing evidence from animal models that intermittent hypoxemia (IH) may induce dyslipidemia. Altered lipid metabolism may contribute to the increased cardiovascular risk observed in obstructive sleep apnea (OSA). In this multisite, cross-sectional study, we tested the hypothesis that there is an independent association between nocturnal IH and dyslipidemia in OSA. METHODS: Fasting serum lipid levels were measured in 2,081 patients (638 women) undergoing nocturnal recording for clinical suspicion of OSA...
June 2013: Chest
Ioná Zalcman Zimberg, Silvio A Fernandes Junior, Cibele Aparecida Crispim, Sergio Tufik, Marco Tulio de Mello
In developing countries, shift work represents a considerable contingent workforce. Recently, studies have shown that overweight and obesity are more prevalent in shift workers than day workers. In addition, shift work has been associated with a higher propensity for the development of many metabolic disorders, such as insulin resistance, diabetes, dislipidemias and metabolic syndrome. Recent data have pointed that decrease of the sleep time, desynchronization of circadian rhythm and alteration of environmental aspects are the main factors related to such problems...
2012: Work: a Journal of Prevention, Assessment, and Rehabilitation
Yolande Esquirol, Bertrand Perret, Jean Bernard Ruidavets, Jean Claude Marquie, Eloi Dienne, Michel Niezborala, Jean Ferrieres
Cardiovascular diseases remain a major public health problem. The involvement of several occupational factors has recently been discussed, notably the organization of work schedules, e.g. shift work. To analyse the progress of knowledge on the relationship between cardiovascular risk factors and shift work. A review of English-language literature dealing with the link between cardiovascular factors and shift workers (published during 2000-2010) was conducted. Studies published in the past 10 years tend to document an impact of shift work on blood pressure, lipid profile (triglyceride levels), metabolic syndrome and, possibly, body mass index...
December 2011: Archives of Cardiovascular Diseases
Mariana Santos Felisbino-Mendes, Tatiane Géa-Horta, Antônio Luiz Pinho Ribeiro, Gilberto Kac, Salete Maria de Fátima Silqueira, Gustavo Velásquez-Meléndez
OBJECTIVE: To investigate associations between metabolic syndrome (MS) and 24-hour blood pressure parameters as a measure of cardiovascular risk (CVR). SUBJECTS AND METHODS: 136 hypertensive subjects, of both sexes, aged between 29 and 83 years were studied. CVR was defined as having at least three of the following conditions: 1) systolic/diastolic blood pressure (BP) ≥ 140/90 mmHg, absence/attenuation of nighttime fall in BP during sleep, pulse pressure (PP) ≥ 53 mmHg; 2) 24-h PP > 53 mmHg, 3) nighttime PP > 53 mmHg, 4) daytime PP > 53 mmHg and 5) nighttime fall in BP during sleep...
August 2011: Arquivos Brasileiros de Endocrinologia e Metabologia
Luciano F Drager, Pedro R Genta, Rodrigo P Pedrosa, Flávia B Nerbass, Carolina C Gonzaga, Eduardo M Krieger, Geraldo Lorenzi-Filho
Obstructive sleep apnea (OSA) is a secondary cause of hypertension and independently associated with target-organ damage in hypertensive patients. However, OSA remains largely underdiagnosed and undertreated. The aim of the present study was to evaluate the characteristics and clinical predictors of OSA in a consecutive series of patients followed up in a hypertension unit. A total of 99 patients (age 46 + or - 11 years, body mass index 28.8 kg/m(2), range 25.1 to 32.9) underwent polysomnography. The clinical parameters included age, gender, obesity, daytime sleepiness, snoring, Berlin Questionnaire, resistant hypertension, and metabolic syndrome...
April 15, 2010: American Journal of Cardiology
T Mosendane, T Mosendane, F J Raal
The practice of shift-work scheduling has long been part of normal work duties in emergency services such as health and security. It is only recently, in the wake of growing job opportunities and booming industries, where more employees are needed to keep services running over 24-hour periods that studies on the effects of shift work on workers' health have begun to delve deeper. The desynchronisation that occurs in circadian rhythms, with respect to sleep cycles, predisposes employees to coronary heart disease, gastrointestinal disturbances, increased risk of breast cancer and poor pregnancy outcomes...
July 2008: Cardiovascular Journal of Africa
Robert Wolk, Virend K Somers
The metabolic syndrome represents a clustering of several interrelated risk factors of metabolic origin that are thought to increase cardiovascular risk. It is still uncertain whether this clustering results from multiple underlying risk factors or whether it has a single cause. One metabolic abnormality that may underlie several clinical characteristics of the metabolic syndrome is insulin resistance. This review discusses the evidence that sleep disturbances (obstructive sleep apnoea, sleep deprivation and shift work) may independently lead to the development of both insulin resistance and individual clinical components of the metabolic syndrome...
January 2007: Experimental Physiology
D Zdrenghea, Laura Poantă, D Gaita
UNLABELLED: The research considers the hypothesis that stressful professions, such as engine driver, influence the morbidity and mortality through cardiovascular diseases and favour some harmful habits with an impact upon cardiovascular morbidity. METHODS: There were selected for study 496 engine drivers, males, and a control group of 305 males. They were questioned about: name, address, family history, pathological personal history, alcohol intake, smoking, diet habits, physical activity, sleeping hours and stress perception...
2005: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
K Matz, C Tatschl, K Sebek, A Dachenhausen, M Brainin
Previous studies have shown a peak occurrence of ischemic stroke in the morning but no consistent finding has been attributed to this. Focused on lacunar strokes we performed a prospective study with a detailed diagnostic protocol including parameters of recent infection, indicators of sleep apnea and cerebral vasoreactivity (CVR), aimed at defining differences in risk profiles between diurnal and nocturnal strokes. Consecutively we included 33 nocturnal and 54 diurnal strokes. Baseline characteristics, known risk factors, stroke severity and topology were not different between groups...
November 2004: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
Ann L Bugeja, Christopher T Chan
Dyslipidemia is associated with uremia and an increased risk of cardiovascular disease. The uremic dyslipidemia syndrome is characterized by an abnormal lipoprotein profile that results in (1) an elevation of triglyceride (TG) rich lipoproteins, very low density lipoprotein (VLDL), and intermediate density lipoprotein (IDL); (2) a reduction in high density lipoprotein (HDL) levels; and (3) a higher fraction of atherogenic, small dense low density lipoprotein (LDL). Nocturnal hemodialysis (NHD) is a home based renal replacement therapy that provides better control of uremia than conventional hemodialysis (CHD) and that may improve dyslipidemia...
July 2004: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
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