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https://www.readbyqxmd.com/read/29225340/genetic-and-experimental-evidence-for-the-involvement-of-the-cd6-lymphocyte-receptor-in-psoriasis
#1
Marta Consuegra-Fernández, Marc Julià, Mario Martínez-Florensa, Fernando Aranda, Cristina Català, Noelia Armiger-Borràs, María-Teresa Arias, Francisca Santiago, Antonio Guilabert, Anna Esteve, Carlos Muñoz, Carlos Ferrándiz, José-Manuel Carrascosa, Edurne Pedrosa, Jorge Romaní, Mercè Alsina, José-Manuel Mascaró-Galy, Francisco Lozano
Psoriasis is a chronic inflammatory skin disease with a strong genetic background and is triggered by environmental factors. Available evidence supports CD6, a lymphocyte surface receptor mostly expressed by T cells, as a putative target in autoimmunity. Accordingly, a humanized anti-CD6 antibody has been assayed for the treatment of certain autoimmune disorders, including psoriasis. Here, we present novel evidence in mice and humans for a direct involvement of CD6 in psoriasis pathophysiology. First, an attenuated form of imiquimod-induced psoriasis-like skin inflammation was demonstrated in CD6-deficient mice, as deduced from lower epidermal thickness and local reduced production of pro-inflammatory cytokines, namely, interleukin-17A...
December 11, 2017: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29221946/-facing-a-dilemma-in-elderly-complex-and-vulnerable-patients-to-stop-or-not-to-stop-prevention
#2
Laura Llobet Vila, Josep Maria Manresa Domínguez, José Manuel Carmona Segado, Alícia Franzi Sisó, Rosa Vallès Balasch, Isabel Martínez Díaz
OBJECTIVES: 1-To know the preventive prescription (statin, antiplatelet drugs, bisphosphonates, calcium and vitamin D and Vit B12) of elderly patients previously identified as a CCD (with a complex chronic disease) and ACD (with advanced chronic disease and lifetime expectancy of less than 12 months) who died during 2015. 2-To assess the correct indication of Proton Pump Inhibitors (PPI) to determine potentially avoidable medication. DESIGN: Retrospective observational study...
December 5, 2017: Atencion Primaria
https://www.readbyqxmd.com/read/29221172/the-prognostic-value-of-inflammation-based-scores-in-advanced-hepatocellular-carcinoma-patients-prior-to-treatment-with-sorafenib
#3
Guillaume Conroy, Julia Salleron, Arthur Belle, Mouni Bensenane, Abdelbasset Nani, Ahmet Ayav, Didier Peiffert, Anthony Lopez, Cédric Baumann, Hélène Barraud, Jean-Pierre Bronowicki
Background and Aims: The multikinase inhibitor sorafenib is the only currently approved drug for the indication of advanced hepatocellular carcinoma (HCC). It provides a limited gain in survival time but is frequently associated with adverse events. We currently lack simple prognostic factors in sorafenib-treated HCC patients. Various inflammation-based scores (IBSs) have been evaluated as predictors of tumor recurrence and survival in various malignancies (including HCC). The objective of the present study was to determine the prognostic value of IBSs for overall survival (OS) in advanced HCC patients prior to the initiation of sorafenib therapy...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29218860/32nd-international-epilepsy-congress-barcelona-spain-2nd-6th-september-2017
#4
(no author information available yet)
No abstract text is available yet for this article.
December 2017: Epilepsia
https://www.readbyqxmd.com/read/29214157/towards-a-global-initiative-for-fibrosis-treatment-gift
#5
Maria Molina-Molina, Alvar Agusti, Bruno Crestani, David A Schwartz, Melanie Königshoff, Rachel C Chambers, Toby M Maher, Rosa Faner, Ana Lucia Mora, Mauricio Rojas, Katerina M Antoniou, Jacobo Sellares
Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease characterised by increased scarring of lung tissue. Despite the recent introduction of novel drugs that slow disease progression, IPF remains a deadly disease, and the benefits of these new drugs differ markedly between patients. Human diseases arise due to alterations in an almost limitless network of interconnected genes, proteins, metabolites, cells and tissues, in direct relationship with a continuously changing macro- or microenvironment...
October 2017: ERJ Open Research
https://www.readbyqxmd.com/read/29207975/radiomics-based-analysis-to-predict-local-control-and-survival-in-hepatocellular-carcinoma-patients-treated-with-volumetric-modulated-arc-therapy
#6
Luca Cozzi, Nicola Dinapoli, Antonella Fogliata, Wei-Chung Hsu, Giacomo Reggiori, Francesca Lobefalo, Margarita Kirienko, Martina Sollini, Davide Franceschini, Tiziana Comito, Ciro Franzese, Marta Scorsetti, Po-Ming Wang
BACKGROUND: To appraise the ability of a radiomics based analysis to predict local response and overall survival for patients with hepatocellular carcinoma. METHODS: A set of 138 consecutive patients (112 males and 26 females, median age 66 years) presented with Barcelona Clinic Liver Cancer (BCLC) stage A to C were retrospectively studied. For a subset of these patients (106) complete information about treatment outcome, namely local control, was available. Radiomic features were computed for the clinical target volume...
December 6, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29207286/short-term-effects-of-ultrafine-particles-on-daily-mortality-by-primary-vehicle-exhaust-versus-secondary-origin-in-three-spanish-cities
#7
Aurelio Tobías, Ioar Rivas, Cristina Reche, Andrés Alastuey, Sergio Rodríguez, Rocío Fernández-Camacho, Ana M Sánchez de la Campa, Jesús de la Rosa, Jordi Sunyer, Xavier Querol
BACKGROUND: Evidence on the short-term effects of ultrafine particles (with diameter<100nm, UFP) on health is still inconsistent. New particles in ambient urban air are the result of direct emissions and also the formation of secondary UFP from gaseous precursors. We segregated UFP into these two components and investigated their impact on daily mortality in three Spanish cities affected by different sources of air pollution. METHODS: We separated the UFP using a method based on the high correlation between black carbon (BC) and particle number concentration (N)...
December 2, 2017: Environment International
https://www.readbyqxmd.com/read/29206008/mental-hygiene-in-early-francoism-from-racial-hygiene-to-the-prevention-of-mental-illness-1939-1960
#8
Ricardo Campos, Enric Novella
In this paper, we study the ideological bases of mental hygiene, understood as racial and moral hygiene, during the first years of Franco's regime and their evolution until 1960. First, we discuss the conceptualization of mental hygiene in the 1940s and its role as a tool for the legitimization of dictatorship, revealing the involvement of orthodox Catholicism and its links with moral and racial hygiene. Second, we assess the transformation of mental hygiene during the 1950s towards modernization and a stronger linkage with the dominant trends of contemporary psychiatry without ever leaving the ideological background of Catholicism...
2017: Dynamis
https://www.readbyqxmd.com/read/29206006/the-beginning-of-francoist-psychiatry-the-national-neurology-and-psychiatry-conference-barcelona-1942
#9
Rafael Huertas
While there has been some research into Francoist psychiatry, much work still needs to be done on the reorganization of the mental health profession within the new state. Held in Barcelona on 12, 13 and 14th January 1942, the National Neurology and Psychiatry Conference undoubtedly played a major role in the attempt to overthrow the dominant ideas in the field of Spanish psychiatry and displace its most influential figures. This article seeks to analyse the Conference's main organizational features and examine its most significant content, with the aim of evaluating its strategic importance in the context of both the psychiatrists' professional and scientific interests and their ideological and political concerns...
2017: Dynamis
https://www.readbyqxmd.com/read/29202897/prevalence-of-mrsa-st398-carriage-in-nursing-home-residents-in-an-area-of-spain-with-a-high-density-of-pig-farming
#10
Esteban Reynaga, Carmen Torres, Marian Garcia-Nuñez, Marian Navarro, Anna Vilamala, Emma Puigoriol, Gianni Enrico Lucchetti, Daniella Nunes, Adriana Silva, Miquel Sabrià
MRSA nasal carriage was detected in 15.7% of 204 residents from 6 nursing homes (NHs) in the Osona region (Barcelona, Spain), and the MRSA-ST398 lineage was identified in 15.6% of MRSA-positive residents and in 2.5% of all NH residents evaluated. Most MRSA-ST398 carriers (4 of 5) had direct or indirect contact with pig farms. Infect Control Hosp Epidemiol 2017;1-4.
December 5, 2017: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/29199762/m-resist-a-complete-m-health-solution-for-patients-with-treatmentresistant-schizophrenia-a-qualitative-study-of-user-needs-and-acceptability-in-the-barcelona-metropolitan-area
#11
Elena Huerta-Ramos, Silvia Marcó-García, Maria Soledad Escobar-Villegas, Elena Rubio-Abadal, Susana Ochoa, Eva M Grasa Bello, Anna Alonso Solís, Mireia Rabella, Jesús Berdun, Margarita Hospedales, Group M-Resist, Iluminada Corripio, Judith Usall
BACKGROUND: Despite the theoretical potential of m-health solutions in the treatment of patients with schizophrenia, there remains a lack of technological solutions in daily practice. The aim of this study was to measure the receptivity of patients, informal carers, and clinicians to an integral intervention model focused on patients with persistent positive symptoms: Mobile Therapeutic Attention for Patients with Treatment Resistant Schizophrenia (m-RESIST). METHODS: A qualitative study of the needs and acceptability of outpatients with treatment-resistant schizophrenia was carried out in Parc Sanitari Sant Joan de Déu (Barcelona)...
November 2017: Actas Españolas de Psiquiatría
https://www.readbyqxmd.com/read/29199713/stereotactic-body-radiation-therapy-for-hepatocellular-carcinoma-experience-from-a-tertiary-cancer-care-center-in-india
#12
R Madhavan, B Kunher, M Arunlal, H M Nair, U G Unnikrishnan, R Holla, D Makuny
AIM: The aim of this retrospective study is to assess the toxicity and tumor response of stereotactic body radiation therapy (SBRT) protocol for hepatocellular carcinoma (HCC) in our institution. BACKGROUND: Hepatocellular cancer is one of the leading cancers among men in India. In recent years, SBRT has emerged as a promising tool in the treatment of HCC. MATERIALS AND METHODS: Ten patients diagnosed as HCC with Barcelona Clinic Liver Cancer Stage B and C, treated with SBRT technique from January 2013 to December 2016, were included in this study...
January 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29199380/liver-resection-for-hcc-outside-the-bclc-criteria
#13
Manish S Bhandare, Shraddha Patkar, Nitin Shetty, Ashwin Polnaya, Suyash Kulkarni, Rohit R Dusane, Shailesh V Shrikhande, Mahesh Goel
PURPOSE: Surgical resection still remains the mainstay of management of hepatocellular carcinoma (HCC). At present, Barcelona clinic liver cancer (BCLC) staging is the most widely used tool to guide treatment; however, criteria for offering surgery as curative treatment are restrictive. We aimed to evaluate short-term and long-term outcomes of HCC after resection, even for patients outside BCLC criteria for resection. METHODS: Data was collected from a prospective database from GI and HPB Department, Tata Memorial Hospital, Mumbai...
December 4, 2017: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/29198946/prognostic-factors-for-survival-after-transarterial-chemoembolization-combined-with-sorafenib-in-the-treatment-of-bclc-stage-b-and-c-hepatocellular-carcinomas
#14
Jia-Yan Ni, Jian Kong, Hong-Liang Sun, Yao-Ting Chen, Jiang-Hong Luo, Wei-Dong Wang, Dong Chen, Xiong-Ying Jiang, Lin-Feng Xu
RATIONALE AND OBJECTIVE: The objective of this study was to analyze prognostic factors for survival after transarterial chemoembolization (TACE) combined with sorafenib for hepatocellular carcinoma (HCC) of Barcelona Clinic Liver Cancer (BCLC) stages B and C. MATERIALS AND METHODS: Clinical data of 198 patients with BCLC stage B and C HCCs who underwent TACE combined with sorafenib between June 2012 and January 2017 were retrospectively collected and analyzed. Survival curves were detected using log-rank test...
November 29, 2017: Academic Radiology
https://www.readbyqxmd.com/read/29198662/epidemiology-and-risk-factors-for-cancer-after-lung-transplantation
#15
C Berastegui, R LaPorta, M López-Meseguer, L Romero, S Gómez-Ollés, J Riera, V Monforte, B Sáez, C Bravo, A Roman, P Ussetti
Cancer is the third most common cause of death among lung transplant (LT) recipients who survive for more than 1 year. The purpose of this study was to analyze the incidence and risk factors for cancer after LT in a Spanish cohort. The epidemiology and risk factors for cancer were retrospectively analyzed in LT recipients from 2 cities in Spain, Madrid and Barcelona. Of the 1353 LT patients initially included in the study, 125 (9.2%) developed cancer after a mean of 3.7 years. This frequency was 5-fold higher than in the general population...
December 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/29198657/association-of-brain-dead-donors-terminal-inflammation-with-delayed-graft-function-in-kidney-transplant-recipients
#16
D Cucchiari, J Rovira, D Paredes, P Ventura-Aguiar, A Sanchez-Escuredo, M Solé, R Adalia, F Oppenheimer, F Diekmann, I Revuelta
BACKGROUND: Systemic inflammation affects kidney function in a wide range of diseases. Even in kidney transplant recipients, higher levels of C-reactive protein (CRP) are invariably associated with both worse short- and long-term graft outcomes. However, little is known about systemic inflammation in kidney donors and, notably, brain death causes a strong systemic inflammatory response. OBJECTIVE: To analyze the role of systemic inflammation of brain-dead donors on short-term kidney graft outcomes (ie, delayed graft function [DGF], defined as the need of dialysis during the first week after transplantation)...
December 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/29198652/lorraine-racusen-and-kim-solez-awarded-the-gold-medal-of-the-catalan-transplant-society
#17
D Serón, A Roman
In March 2017, a joint meeting between The Catalan Society of Transplantation and the Banff Foundation was held at the University of Barcelona. This was an opportunity for the Catalan Society of Transplantation to recognize the crucial contributions to transplant pathology made by Lorraine Racusen and Kim Solez, who created and actively contributed to the development of the International Banff Classification System. The ceremony of the Gold Medal took place on March 31 at the University of Barcelona; it consisted of a presentation of the contributions of Lorraine Racusen and Kim Solez to the development of transplant pathology...
December 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/29197439/halitosis-assessment-and-changes-in-volatile-sulfur-compounds-after-chewing-gum-a-study-performed-on-dentistry-students
#18
Mayra Schemel-Suárez, Eduardo Chimenos-Küstner, Albert Estrugo-Devesa, Enric Jané-Salas, José López-López
OBJECTIVE: The objective of this study is to estimate the prevalence of halitosis (with subjective and objective methods), evaluate the immediate effect of chewing gum on volatile sulfur compounds (VSCs), assess the perception of halitosis by dentistry students, and estimate the distribution of positive and negative frequencies, when comparing objective and subjective methods for the diagnosis of halitosis. METHODS: The study was performed on a sample of dentistry students attending the Faculty of Medicine and Health Sciences at the University of Barcelona...
December 2017: Journal of Evidence-based Dental Practice
https://www.readbyqxmd.com/read/29195209/daphnia-magna-filtration-efficiency-and-mobility-in-laminar-to-turbulent-flows
#19
Teresa Serra, Aina Barcelona, Marçal Soler, Jordi Colomer
Daphnia are filter feeder organisms that prey on small particles suspended in the water column. Since Daphnia individuals can feed on wastewater particles, they have been recently proposed as potential organisms for tertiary wastewater treatment. However, analysing the effects of hydrodynamics on Daphnia individuals has scarcely been studied. This study focuses then, on quantifying the filtration and swimming velocities of D. magna individuals under different hydrodynamic conditions. Both D. magna filtration and movement responded differently if the flow was laminar or if it was turbulent...
November 28, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29194711/institutional-decision-to-adopt-y90-as-primary-treatment-for-hcc-informed-by-a-1-000-patient-15-year-experience
#20
Riad Salem, Ahmed Gabr, Ahsun Riaz, Ronald Mora, Rehan Ali, Michael Abecassis, Ryan Hickey, Laura Kulik, Daniel Ganger, Steven Flamm, Rohi Atassi, Bassel Atassi, Kent Sato, Al B Benson, Mary F Mulcahy, Nadine Abouchaleh, Ali Al Asadi, Kush Desai, Bartley Thornburg, Michael Vouche, Ali Habib, Juan Caicedo, Frank H Miller, Vahid Yaghmai, Joseph R Kallini, Samdeep Mouli, Robert J Lewandowski
Y90 transarterial radioembolization (TARE) is a transarterial locoregional therapy (LRT) for hepatocellular carcinoma (HCC). In this study, we present overall survival outcomes (OS) in a 1000-patient cohort acquired over a 15-year period. Between December 1, 2003 and March 31, 2017, 1000 patients with HCC were treated with TARE as part of a prospective cohort study. A comprehensive review of toxicity and survival outcomes was performed. Outcomes were stratified by baseline Child-Pugh (CP) class, United Network for Organ Sharing (UNOS) and Barcelona Clinic Liver Cancer (BCLC) staging systems...
December 1, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
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