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Bin-Bin Cai, Ke-Qing Shi, Peng Li, Bi-Cheng Chen, Liang Shi, Philip J Johnson, Paul Lai, Hidenori Toyoda, Meng-Tao Zhou
BACKGROUND: Because of the mutual influence of liver dysfunction and malignancy, overall survival (OS) is a composite clinical endpoint in hepatocellular carcinoma (HCC). We developed a nomogram integrating albumin-bilirubin (ALBI) grade, a new index of hepatic reserve, and tumor characteristics of HCC for predicting OS following curative liver resection. METHODS: The nomogram was built to estimate the probabilities of 1, 3, and 5-y OS based on training cohort of 709 HCC, which was validated in an international independent dataset...
June 14, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
Raquel Garcia, Rosa Abellana, Jordi Real, José-Luis Del Val, Jose Maria Verdú-Rotellar, Miguel-Angel Muñoz
BACKGROUND: Information regarding the effect of social determinants of health on heart failure (HF) community-dwelling patients is scarce. We aimed to analyse the presence of socioeconomic inequalities, and their impact on hospitalisations and mortality, in patients with HF attended in a universal healthcare coverage system. METHODS: A retrospective cohort study carried out in patients with HF aged >40 and attended at the 53 primary healthcare centres of the Institut Català de la Salut in Barcelona (Spain)...
June 13, 2018: Journal of Epidemiology and Community Health
Ana Nadal, Oriol Pons, Eva Cuerva, Joan Rieradevall, Alejandro Josa
Today, urban agriculture is one of the most widely used sustainability strategies to improve the metabolism of a city. Schools can play an important role in the implementation of sustainability master plans, due their socio-educational activities and their cohesive links with families; all key elements in the development of urban agriculture. Thus, the main objective of this research is to develop a procedure, in compact cities, to assess the potential installation of rooftop greenhouses (RTGs) in schools. The generation of a dynamic assessment tool capable of identifying and prioritizing schools with a high potential for RTGs and their eventual implementation would also represent a significant factor in the environmental, social, and nutritional education of younger generations...
June 1, 2018: Science of the Total Environment
Barend L van Drooge, Raimon M Prats, Cristina Reche, MariCruz Minguillón, Xavier Querol, Joan O Grimalt, Teresa Moreno
Underground subways transport large numbers of citizens in big cities, which must breathe air with limited ventilation. These atmospheric conditions may enhance the concentration of air pollutants from both outdoor and indoor air. The influence of ventilation conditions and maintenance activities on the concentrations of air pollutants have been studied. Particulate matter with aerodynamic diameter smaller than 2.5 μm (PM2.5 ) in indoor air was sampled in ten platforms of nine subway stations of the metropolitan area of Barcelona in 2015 and 2016...
June 9, 2018: Science of the Total Environment
Rosa Fernández, Antonio Guillamón, Esther Gómez-Gil, Isabel Esteva, Mari Cruz Almaraz, Joselyn Cortés-Cortés, Beatriz Lamas, Estefanía Lema, Eduardo Pásaro
Gender Dysphoria is characterized by a marked incongruence between the cerebral sex and biological sex. To investigate the possible influence of karyotype on the etiology of Gender Dysphoria we carried out the cytogenetic analysis of karyotypes in 444 male-to-females (MtFs) and 273 female-to-males (FtMs) that attended the Gender Identity Units of Barcelona and Málaga (Spain) between 2000 and 2016. The karyotypes from 23 subjects (18 MtFs and 5 FtMs) were also analysed by Affymetrix CytoScan™ high-density (HD) arrays...
May 2018: Genes & Genomics
Jialiang Chen, Dongying Xue, Fangyuan Gao, Le Tao, Yuxin Li, Qun Zhang, Rui Wang, Le Sun, Xue Yang, Yao Liu, Bingbing Zhu, Shuaishuai Niu, Xianbo Wang
AIMS: The biochemical response after ursodeoxycholic acid (UDCA) treatment contributes toward predicting the prognosis for primary biliary cholangitis (PBC) patients. This study aimed to establish a score model that can be used for predicting the biochemical response. PATIENTS AND METHODS: A total of 218 patients in the derivation group and 66 patients in the verification group were enrolled. Response endpoints were based on the Barcelona criteria combined with the Paris I criteria...
June 8, 2018: European Journal of Gastroenterology & Hepatology
Oscar Ramos-Campoy, Rainiero Ávila-Polo, Oriol Grau-Rivera, Anna Antonell, Jordi Clarimón, Ricardo Rojas-García, Sara Charif, Veronica Santiago-Valera, Isabel Hernandez, Miquel Aguilar, Consuelo Almenar, Dolores Lopez-Villegas, Lorena Bajo, Pau Pastor, Julie Van der Zee, Albert Lladó, Raquel Sanchez-Valle, Ellen Gelpi
The neuropathological hallmark of the C9orf72 intronic hexanucleotide expansion in frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS) is the presence of small ubiquitin/p62-positive and transactive response DNA binding protein 43 kDa (TDP-43)-negative cytoplasmic inclusions in several brain areas. The identification of this histopathological signature is highly predictive of an underlying mutation. In this study, we screened 1800 cases of the Barcelona IDIBAPS Brain Bank, independently of the clinical and final neuropathological diagnosis of the brain donor, for the presence of ubiquitin/p62-positive inclusions in the cerebellum (UPPI)...
June 7, 2018: Journal of Neuropathology and Experimental Neurology
Naoko Kamo, Toshimi Kaido, Shintaro Yagi, Hideaki Okajima, Shinji Uemoto
Transarterial chemoembolization is the standard treatment for patients with intermediate-stage hepatocellular carcinoma (HCC) according to the Barcelona Clinic Liver Cancer staging system. However, in Japan, not a few patients with intermediate-stage HCC undergo liver transplantation (LT). The present study investigated characteristics and outcomes of LT for intermediate-stage HCC. Between February 1999 and November 2016, a total of 226 patients underwent LT for HCC at our institute. Among these, 56 patients showed intermediate-stage HCC (24...
May 2018: Liver Cancer
Mikhail S Chesnokov, Polina A Khesina, Darya A Shavochkina, Inna F Kustova, Leonid M Dyakov, Olga V Morozova, Nikolai S Mugue, Nikolay E Kudashkin, Ekaterina A Moroz, Yuri I Patyutko, Natalia L Lazarevich
Background: Hepatocellular carcinoma (HCC) is the most common and aggressive type of malignant liver tumor. HCC progression depends significantly on its vascularization and formation of new blood vessels. Vascular endothelial growth factor A (VEGFA) is a crucial regulator of tumor vascularization and components of VEGF-induced cell signaling pathways are important targets of therapeutical drugs that demonstrated the highest efficiency in case of advanced HCC (sorafenib and regorafenib)...
2018: PeerJ
Mauricio Polanco-García, Ana María Capielo, Xavier Miret, Antonio Chamero, Julio Sainz, Elena Revilla, Antoni Guinjoan, Teresa Arranz
BACKGROUND AND OBJECTIVES: Patient blood management in orthopaedic surgery reduces transfusion risk. The best protocol is unknown. The effectiveness of a protocol based on the Seville Consensus on the reduction of transfusion risk is evaluated and a predictive transfusion equation is proposed in knee surgery. PATIENTS AND METHODS: Cohort study in patients undergoing knee and hip arthroplasty from January 2014 to December 2015 at a second level complexity hospital in Vilafranca del Penedès (Barcelona)...
June 7, 2018: Medicina Clínica
Antonio Carrascosa, Jordi Mesa
No abstract text is available yet for this article.
June 2018: Endocrinología, Diabetes y Nutrición
M C Pavel, S Sanchez Cabus, G Crespo, J Ferrer, C Fondevila, J Fuster, J C Garcia-Valdecasas
BACKGROUND AND AIMS: In the context of the shortage of donors, adult living donor liver transplantation (aLDLT) represents a feasible alternative for patients within as well as beyond the Milan criteria. METHODS: From 2001, we performed 42 aLDLTs for hepatocellular carcinoma (HCC). Sixteen of the recipients were within the Milan criteria, whereas 26 fulfilled the Barcelona-Clinic Liver Cancer Group (BCLC) expanded criteria (1 tumor ≤7 cm, 5 tumors ≤3 cm, or tumors 3 ≤5 cm without macrovascular invasion or down-staging to Milan after loco-regional therapies)...
June 2018: Transplantation Proceedings
(no author information available yet)
No abstract text is available yet for this article.
May 2018: European Journal of Clinical Investigation
(no author information available yet)
No abstract text is available yet for this article.
June 5, 2018: Dysphagia
Ryan Scarrow
No abstract text is available yet for this article.
June 2018: Nature Plants
Jessica Clymer, Mark W Kieran
Dramatic advances in the molecular analysis of diffuse intrinsic pontine glioma have occurred over the last decade and resulted in the identification of potential therapeutic targets. In spite of these advances, no significant improvement in the outcome has been achieved and median survival remains approximately 10 months. An understanding of the approaches that have been taken to date, why they failed, and how that information can lead the field forward is critical if we are to change the status quo . In this review, we will discuss the clinical trial landscape in North America with an overview of historical approaches that failed and what might account for this failure...
2018: Frontiers in Oncology
Kathryn Beardsall, Lynn Thomson, Catherine Guy, Mirjam M van Weissenbruch, Isabel Iglesias, Priya Muthukumar, Sateesh Kumar Somisetty, Simon Bond, Stavros Petrou, David Dunger
INTRODUCTION: Hyperglycaemia is common in the very preterm infant and has been associated with adverse outcomes. Preventing hyperglycaemia without increasing the risk of hypoglycaemia has proved challenging. The development of real-time continuous glucose monitors (CGM) to inform treatment decisions provides an opportunity to reduce this risk. This study aims to assess the feasibility of CGM combined with a specifically designed paper guideline to target glucose control in the preterm infant...
June 4, 2018: BMJ Open
Daisuke Ban, Toshiro Ogura, Keiichi Akahoshi, Minoru Tanabe
Treatment strategy for hepatocellular carcinoma (HCC) requires optimal selection of therapies based on various factors related to tumor condition and liver functional reserve. Although several evidence-based guidelines have been proposed for the treatment of HCC, the criteria and range of indications differ among these guidelines according to the circumstances of each country. In European nations and the USA, patients with the Barcelona Clinic Liver Cancer stage 0-A are subjects for surgical resection, whereas in Asian countries, even those with the intermediate stage are regarded as surgical candidates...
March 2018: Annals of gastroenterological surgery
X L Wu, X Y Bi, Z Y Li, H Zhao, J J Zhao, J G Zhou, Z Huang, Y F Zhang, J Q Cai
Objective: To investigate the correlation between postoperative peripheral blood neutrophil to lymphocyte ratio (NLR) and recurrence and prognosis of patients with hepatocellular carcinoma (HCC). Methods: The clinicopathological and follow-up data of 344 patients with HCC who underwent radical liver resection from May 2010 to April 2014 were analyzed retrospectively. Results: Of the 344 patients, 104 had early recurrence and 84 had late recurrence. Receiver operating characteristic (ROC) curve analysis showed that the NLR predicted area under the curve (AUC) of early recurrence was 0...
May 23, 2018: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
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