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https://www.readbyqxmd.com/read/29655966/secular-trends-in-the-epidemiology-of-clostridium-difficile-infection-cdi-at-a-tertiary-care-hospital-in-barcelona-2006-2015-a-prospective-observational-study
#1
Thais Larrainzar-Coghen, Dolors Rodríguez-Pardo, Nuria Fernández-Hidalgo, Mireia Puig-Asensio, Carles Pigrau, Carmen Ferrer, Virginia Rodríguez, Rosa Bartolomé, David Campany, Benito Almirante
OBJECTIVE: Describe secular trends in the epidemiology and outcome of Clostridium difficile infection (CDI) at a tertiary hospital. METHODS: All consecutive primary CDI episodes in adults (January 2006-December 2015) were included. CDI was diagnosed on the presence of diarrhoea and a positive stool test for C. difficile toxin A and/or B. To define trends, a time-series analysis was performed using yearly data on demographics, clinical characteristics, management, antimicrobial treatment, and outcome of CDI...
April 12, 2018: Anaerobe
https://www.readbyqxmd.com/read/29629396/anti-nmda-receptor-encephalitis-and-nonencephalitic-hsv-1-infection
#2
Amy Salovin, Jason Glanzman, Kylie Roslin, Thais Armangue, David R Lynch, Jessica A Panzer
Objective: To determine whether there is an association between nonencephalitic herpes simplex virus 1 (HSV-1) infection and anti-NMDA receptor encephalitis (anti-NMDARE). Methods: Antibody testing was performed using samples from 2 cohorts in a case-control observational study. The cohort "Philadelphia" included 16 serum samples of pediatric anti-NMDARE cases and 42 age-matched controls with other neuroinflammatory disorders studied at the Children's Hospital of Philadelphia and University of Pennsylvania...
July 2018: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/29627662/follow-up-of-fetuses-with-congenital-diaphragmatic-hernia-the-quantitative-lung-index
#3
Carlota Rodó, Tamara Illescas, Silvia Arévalo, Santiago Pérez-Hoyos, Elena Carreras
OBJECTIVE: To assess the longitudinal behavior of Quantitative Lung Index (QLI) for the follow-up of fetuses with congenital diaphragmatic hernia. STUDY DESIGN: Retrospective study of fetuses with isolated left congenital diaphragmatic hernia. The fetuses were assessed by ultrasound at different gestational ages and QLI was retrospectively calculated by means of previous lung-to-head ratio measurements. We used a random effects model (mixed model with repeated measurements) to compare the performance of the QLI in operated and non-operated fetuses throughout pregnancy...
March 26, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29626174/acceptability-and-effectiveness-of-using-mobile-applications-to-promote-hiv-and-other-sti-testing-among-men-who-have-sex-with-men-in-barcelona-spain
#4
Miguel Alarcón Gutiérrez, Manuel Fernández Quevedo, Silvia Martín Valle, Constanza Jacques-Aviñó, Elia Díez David, Joan A Caylà, Patricia Gracía de Olalla
OBJECTIVE: To evaluate the acceptability and effectiveness of a pilot intervention programme using gay geosocial mobile applications (apps) to offer rapid HIV and other STI tests to men who have sex with men (MSM) in Barcelona between December 2015 and March 2016. METHODOLOGY: We offered rapid HIV, syphilis and hepatitis C testing by sending private messages on apps for sexual and social encounters. Acceptance was defined as the proportion of users who favourably responded to the message and effectiveness was defined as the proportion of users who attended our facilities among those who were interested in attending...
April 6, 2018: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/29621962/maternal-hair-and-neonatal-meconium-to-assess-gestational-consumption-and-prenatal-exposure-to-drugs-of-abuse-and-psychoactive-drugs
#5
Francesco Paolo Busardo, Laura Almeida, Laura Cortes, Sally Sabraa, Marta Muniesaa, Oscar Garcia-Algara, Maria Dolores Gomez-Roiga
BACKGROUND: In the last two decades, the consumption of drugs of abuse among women of childbearing age has experienced a significant increase and results from analyses of surveys concerning maternal intake of psychoactive prescription drugs during pregnancy indicate that the rates of intake are increasing each year. Analyses of biological matrices such as maternal hair and neonatal meconium have recently been used for assessment of gestational consumption and consequent prenatal exposure to drugs of abuse in high-risk groups of women METHODS: Maternal hair and neonatal meconium were analyzed by validated chromatographic mass spectrometric methodologies to disclose gestational use of drugs of abuse and psychoactive prescription drugs and consequent prenatal exposure in a cohort of 513 mother-newborn dyads at the Sant Joan de Déu Barcelona Hospital, Spain, during 2012- 2013...
April 5, 2018: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/29617435/evaluation-of-survival-of-patients-with-hepatocellular-carcinoma-a-comparative-analysis-of-prognostic-systems
#6
R K Tannus, S R Almeida-Carvalho, C A Loureiro-Matos, A Miziara-Gonzalez, A A Salzedas-Netto, D Szejnfeld, G D'Ippolito, V Pereira-Lanzoni, I Souza-Silva
BACKGROUND AND AIM: There are several prognostic systems that address different aspects of the patient and the tumour and can guide the management of patients with hepatocellular carcinoma (HCC). This study aimed to evaluate and compare the eight staging systems for a group of patients in a public service in Brazil. METHODS: Patients with HCC were retrospectively analysed between 2000 and 2012. The prognostic systems Okuda, The Cancer of the Liver Italian Program (CLIP), the Chinese University Prognostic Index (CUPI), Groupe d'Etude et de Traitément du Carcinome Hepatocellulaire (GRETCH), the modified TNM-based Japan Integrated Score (JIS) combined with alpha-fetoprotein and Child-Turcotte-Pugh (CTP), the TNM system, and the Barcelona Clinic Liver Cancer Classification (BCLC) were applied to these patients and compared through model fit measurements, likelihood scores, and the Akaike Information Criterion (AIC)...
2018: PloS One
https://www.readbyqxmd.com/read/29616714/clinical-profile-of-inpatients-referred-to-a-consultation-liaison-psychiatry-service-an-observational-study-assessing-changes-over-a-10-yearperiod
#7
Roberto Sánchez-González, Eva Baillès-Lázaro, Anna Bastidas-Salvadó, Anna Lligoña, Sandra Herranz-Villanueva, Víctor Pérez-Solá, Luis Pintor-Pérez
OBJECTIVE: Previous research has described the characteristics of Consultation-liaison psychiatry (CLP) services over one or more years. The aim of this paper was to examine the patterns of a large sample of patients receiving CLP service over a 10-year-period (2005–2014) and to determine the possible changes over time of the clinical practice. The sample size of our study, the duration of the observation period and the application of standardized operating procedures for acquiring and coding data, will provide more robust evidence than has been reported by most similar studies published in the last years...
March 2018: Actas Españolas de Psiquiatría
https://www.readbyqxmd.com/read/29609903/transarterial-chemoembolization-tace-in-the-management-of-hepatocellular-carcinoma-results-of-a-french-national-survey-on-current-practices
#8
A Fohlen, J P Tasu, H Kobeiter, J M Bartoli, J P Pelage, B Guiu
PURPOSE: To report current practices of transarterial chemoembolization (TACE) by interventional radiologists (IR) for hepatocellular carcinoma (HCC) through a French national survey. MATERIALS AND METHODS: An electronic survey was sent by e-mail to 232 IRs performing TACE in 32 private or public centers. The survey included 66 items including indications for TACE, technical aspects of TACE, other locally available treatments for HCC, follow-up imaging and general aspects of interventional radiology practices...
March 30, 2018: Diagnostic and Interventional Imaging
https://www.readbyqxmd.com/read/29608816/metastasis-in-patients-with-hepatocellular-carcinoma-prevalence-determinants-prognostic-impact-and-ability-to-improve-the-bclc-system
#9
Chia-Yang Hsu, Po-Hong Liu, Shu-Yein Ho, Yi-Hsiang Huang, Yun-Hsuan Lee, Rheun-Chuan Lee, Teddy S Nagaria, Ming-Chih Hou, Teh-Ia Huo
BACKGROUND & AIM: Patients with hepatocellular carcinoma (HCC) and metastasis are classified as advanced or terminal stage by the Barcelona Clinic Liver Cancer (BCLC) system. This study investigates the prevalence, determinants, and prognostic effect of metastasis, and its ability to improve the BCLC system. METHODS: A total of 3,414 patients were enrolled. The Kaplan-Meier and Cox regression methods were used to determine survival predictors. Akaike information criterion (AIC) was used to compare the prognostic performance of staging systems...
April 2, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29606996/structural-changes-of-subcutaneous-tissue-valued-by-ultrasonography-in-patients-with-cellulitis-following-treatment-with-the-pnkcelulitis-%C3%A2-program
#10
Esther Roe, Esther Serra, German Guzman, Ignacio Sajoux
Background: Poor eating habits, a sedentary lifestyle, and limited physical activity are predisposing factors for the development of cellulite. The PnKCelulitis® Programme (Pronokal Group, Barcelona, Spain) is a new approach to the treatment of cellulite that combines dietary guidelines, physical exercise, and the application of an anti-cellulite cream. Objective: We sought to objectively and via cutaneous ultrasound assess the benefit of the new multidisciplinary anti-cellulite treatment program and to evaluate any visual changes in the appearance of the skin...
March 2018: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/29606127/stand-by-emergency-treatment-sbet-of-malaria-in-spanish-travellers-a-cohort-study
#11
Pietro Ferrara, Cristina Masuet-Aumatell, Fernando Agüero, Josep Maria Ramon-Torrell
BACKGROUND: Among strategies for malaria prevention, stand-by emergency treatment (SBET) is a possible approach, but scarce evidences exists investigating travellers' adherence and behaviours toward its use; therefore, the presented study aimed to determine travellers' compliance toward the SBET when prescribed in travel clinics. METHODS: A prospective cohort study was performed at the Travel Health Clinic of the Hospital Universitari de Bellvitge, Barcelona, Spain, during 2017...
April 2, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29602433/improving-resident-s-skills-in-the-management-of-circulatory-shock-with-a-knowledge-based-e-learning-tool
#12
David Riaño, Francis Real, Jose Ramon Alonso
BACKGROUND: Correct clinical management of circulatory shock in emergency departments (ER) and intensive care units (ICU) is critical. In this context, the transmission of professional skills by means of the practical supervision of real cases at the point of care entails important issues that can be widely overcome with the use of computer knowledge-based e-learning tools. OBJECTIVE: Shock-Instructor is a web-based e-learning tool implementing the already tested training program model (TPM) that uses a knowledge base about the evidence found in the clinical practice guidelines about seven types of shock...
May 2018: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/29602016/role-of-liver-resection-in-treating-intermediate-and-advanced-stage-adolescent-and-young-adult-hepatocellular-carcinoma-patients-a-propensity-matching-cohort-study
#13
Wei Zhang, Chang Liu, Yifei Tan, Li Jiang, Lunan Yan, Jiayin Yang, Tianfu Wen
BACKGROUND: Hepatocellular carcinoma (HCC) in adolescent and younger adult (AYA) patients is usually diagnosed at an advanced stage such that curative treatments are often not possible. The aimed of this study was to compare the outcome of attempted curative treatment, liver resection (LR) versus transarterial chemoembolization (TACE), in AYA patients presenting with intermediate or advanced HCC defined by the Barcelona Clinic Liver Cancer (BCLC) stage B and C. METHODS: All AYA patients diagnosed with BCLC stage B or C HCC undertaking LR (n = 276) and TACE (n = 136) were included in our study...
March 27, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29594137/artificial-intelligence-for-the-artificial-kidney-pointers-to-the-future-of-a-personalized-hemodialysis-therapy
#14
REVIEW
Miguel Hueso, Alfredo Vellido, Nuria Montero, Carlo Barbieri, Rosa Ramos, Manuel Angoso, Josep Maria Cruzado, Anders Jonsson
Background: Current dialysis devices are not able to react when unexpected changes occur during dialysis treatment or to learn about experience for therapy personalization. Furthermore, great efforts are dedicated to develop miniaturized artificial kidneys to achieve a continuous and personalized dialysis therapy, in order to improve the patient's quality of life. These innovative dialysis devices will require a real-time monitoring of equipment alarms, dialysis parameters, and patient-related data to ensure patient safety and to allow instantaneous changes of the dialysis prescription for the assessment of their adequacy...
February 2018: Kidney Diseases
https://www.readbyqxmd.com/read/29589878/hepatocellular-carcinoma-is-diagnosed-at-a-later-stage-in-alcoholic-patients-results-of-a-prospective-nationwide-study
#15
Charlotte E Costentin, Abbas Mourad, Pierre Lahmek, Xavier Causse, Alexandre Pariente, Hervé Hagège, Anca Stela Dobrin, Claire Becker, Bérangère Marks, Robert Bader, Bertrand Condat, Frédéric Héluwaert, Jean François Seitz, Bruno Lesgourgues, Jacques Denis, Sylvie Deuffic-Burban, Isabelle Rosa, Thomas Decaens
BACKGROUND: Recent data suggest that alcohol-related hepatocellular carcinoma (HCC) is diagnosed at a later stage. The aim of this study was to compare HCC characteristics and outcomes in an alcohol-related group (group A) and a non-alcohol-related group (group NA). METHODS: A total of 1207 patients with newly diagnosed HCC were prospectively included between May 2008 and October 2009. Patients with multiple causes (alcohol plus another cause) were excluded. Patients were followed every year for 5 years...
March 28, 2018: Cancer
https://www.readbyqxmd.com/read/29588611/the-utility-of-pharmacogenetic-testing-to-support-the-treatment-of-bipolar-disorder
#16
Marta Ielmini, Nicola Poloni, Ivano Caselli, Jordi Espadaler, Miquel Tuson, Alessandro Grecchi, Camilla Callegari
Background: Bipolar disorder (BD) is a frequent cause of disability, health care costs, and risk of suicide. Pharmacogenetic tests (PGTs) could help clinicians to identify those patients predisposed to the occurrence of adverse events (AEs) improving the understanding of the correlation between genetic variants and drug response. Materials and methods: The study evaluated 30 patients affected by BD type I or II (according to Diagnostic and Statistical Manual of Mental Disorders, version 5 ) who underwent the PGT Neurofarmagen® (AB-BIOTICS SA, Barcelona, Spain) between March 2016 and March 2017...
2018: Pharmacogenomics and Personalized Medicine
https://www.readbyqxmd.com/read/29577171/social-inequalities-in-the-association-between-temperature-and-mortality-in-a-south-european-context
#17
Marc Marí-Dell'Olmo, Aurelio Tobías, Anna Gómez-Gutiérrez, Maica Rodríguez-Sanz, Patricia García de Olalla, Esteve Camprubí, Antonio Gasparrini, Carme Borrell
OBJECTIVES: To analyse social inequalities in the association between ambient temperature and mortality by sex, age and educational level, in the city of Barcelona for the period 1992-2015. METHODS: Mortality data are represented by daily counts for natural mortality. As a measure of socioeconomic position, we used the educational level of the deceased. We also considered age group and sex. We considered, as a measure of exposure, the daily maximum temperatures...
March 26, 2018: International Journal of Public Health
https://www.readbyqxmd.com/read/29573995/investigation-of-ventricular-pre-excitation-electrocardiographic-pattern-in-two-horses-clinical-presentation-and-potential-causes
#18
Judit Viu, Lara Armengou, Annelies Decloedt, Eduard Jose-Cunilleras
Two horses referred to the Unitat Equina, Fundació Hospital Clínic Veterinari, Universitat Autònoma de Barcelona, for unrelated clinical problems, and with no previous history of cardiac disease exhibited an intermittent ventricular pre-excitation electrocardiographic pattern during hospitalization. Both animals showed decreased plasma total and ionized magnesium concentrations, but no other relevant electrolyte disturbances were detected. Altered interventricular septal motion associated with ventricular pre-excitation beats (VPBs) was detected on M-mode echocardiography in both horses...
March 21, 2018: Journal of Veterinary Cardiology: the Official Journal of the European Society of Veterinary Cardiology
https://www.readbyqxmd.com/read/29573623/social-inequalities-in-quality-of-life-in-a-cohort-of-women-diagnosed-with-breast-cancer-in-barcelona-dama-cohort
#19
Ariadna Graells-Sans, Gemma Serral, Rosa Puigpinós-Riera
BACKGROUND: Breast cancer is a challenge for women's health-related quality of life (QoL), compromising their physical health and emotional well-being. QoL is equally distributed among different social groups. The aim of this study to analyze the impact of clinical characteristics and social determinants of health on the QoL of a cohort of women diagnosed and/or treated for breast cancer between 2003 and 2013 in one of the main hospitals in Barcelona's public health network. METHODS: We performed a descriptive cross-sectional study in a cohort of 2235 women with various stages of breast cancer at different stages of their disease...
March 21, 2018: Cancer Epidemiology
https://www.readbyqxmd.com/read/29569093/interaction-between-hepatocellular-carcinoma-and-hepatitis-c-eradication-with-direct-acting-antiviral-therapy
#20
REVIEW
Venkata Rajesh Konjeti, Binu V John
PURPOSE OF REVIEW: The approval of direct-acting antiviral (DAA) therapy has revolutionized hepatitis C virus (HCV) treatment. However, the publication of a study from Barcelona in 2016 raised concern for an increased risk of recurrence of hepatocellular carcinoma (HCC) after potentially curative therapy in patients receiving DAAs. This article reviews the current literature on the interaction between HCC and hepatitis C eradication with DAAs. RECENT FINDINGS: Following publication of the initial observation in 2016, a number of studies have looked at the impact of active HCC on the success of antiviral therapy, as well as that of treatment with DAAs on both the occurrence and recurrence of HCC...
March 22, 2018: Current Treatment Options in Gastroenterology
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