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https://www.readbyqxmd.com/read/28640606/pharmacokinetics-of-mequindox-and-its-marker-residue-1-4-bisdesoxymequindox-in-swine-following-multiple-oral-gavage-and-intramuscular-administration-an-experimental-study-coupled-with-population-physiologically-based-pharmacokinetic-modeling
#1
Dongping Zeng, Zhoumeng Lin, Binghu Fang, Miao Li, Ronette Gehring, Jim E Riviere, ZhenLing Zeng
Mequindox (MEQ) is a quinoxaline-N,N-dioxide antibiotic used in food-producing animals. MEQ residue in animal-derived foods is a food safety concern. The tissue distribution of MEQ and its marker residue 1,4-bisdesoxymequindox (M1) was determined in swine following oral gavage or intramuscular injection twice daily for 3 days. The experimental data were used to construct a flow-limited physiologically based pharmacokinetic (PBPK) model. The model predictions correlated with available data well. Monte Carlo analysis showed that the times needed for M1 concentrations to fall below limit of detection (5 µg/kg) in liver for the 99th percentile of the population were 27 and 34 days after oral gavage and intramuscular administration twice daily for 3 days, respectively...
June 22, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28636788/role-of-positively-charged-residues-on-the-polar-and-non-polar-faces-of-amphipathic-%C3%AE-helical-antimicrobial-peptides-amps-on-specificity-and-selectivity-for-gram-negative-pathogens
#2
Ziqing Jiang, Colin T Mant, Michael Vasil, Robert S Hodges
We have designed de novo and synthesized eight 26-residue all D-conformation amphipathic α-helical cationic antimicrobial peptides (AMPs), four with "specificity determinants" which provide specificity for prokaryotic cells over eukaryotic cells and four AMPs without specificity determinants. The eight AMPs contain six positively charged Lys residues on the polar face in four different arrangements to understand the role of these residues have on antimicrobial activity against 14 Acinetobacter baumannii strains, 7 of which were resistant to polymyxin B and colistin; 6 diverse Pseudomonas aeruginosa strains and 17 Staphylococcus aureus strains, 9 of which were Methicillin-sensitive (MSSA) and 8 of which were Methicillin-resistant (MRSA)...
June 21, 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/28636355/semisynthetic-flavone-derived-antimicrobials-with-therapeutic-potential-against-methicillin-resistant-staphylococcus-aureus-mrsa
#3
Shuimu Lin, Jun-Jie Koh, Thet Tun Aung, Wan Ling Wendy Sin, Fanghui Lim, Lin Wang, Rajamani Lakshminarayanan, Lei Zhou, Donald T H Tan, Derong Cao, Roger W Beuerman, Li Ren, Shouping Liu
A new series of semisynthetic flavone-based small molecules mimicking antimicrobial peptides has been designed from natural icaritin to combat drug-resistant Gram-positive bacterial infections. Compound 6 containing two arginine residues exhibited excellent antibacterial activity against Gram-positive bacteria, including MRSA, and very low toxicity to mammalian cells, resulting in a high selectivity of more than 511, comparable to that of several membrane-active antibiotics in clinical trials. Our data show for the first time that icaritin derivatives effectively kill bacteria...
June 21, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28633103/dietary-risk-ranking-for-residual-antibiotics-in-cultured-aquatic-products-around-tai-lake-china
#4
Chao Song, Le Li, Cong Zhang, Liping Qiu, Limin Fan, Wei Wu, Shunlong Meng, Gengdong Hu, Jiazhang Chen, Ying Liu, Aimin Mao
Antibiotics are widely used in aquaculture and therefore may be present as a dietary risk in cultured aquatic products. Using the Tai Lake Basin as a study area, we assessed the presence of 15 antibiotics in 5 widely cultured aquatic species using a newly developed dietary risk ranking approach. By assigning scores to each factor involved in the ranking matrices, the scores of dietary risks per antibiotic and per aquatic species were calculated. The results indicated that fluoroquinolone antibiotics posed the highest dietary risk in all aquatic species...
June 17, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28633099/simultaneous-and-specific-enrichment-of-several-amphenicol-antibiotics-residues-in-food-based-on-novel-aptamer-functionalized-magnetic-adsorbents-using-hplc-dad
#5
Shengfeng Huang, Ning Gan, Haibo Liu, You Zhou, Yinji Chen, Yuting Cao
In this work, a novel aptamer functionalized magnetic adsorbent was developed and combined with magnetic dispersive solid phase extraction (MDSPE) for selective enrichment of several amphenicol antibiotics residues (chloramphenicol(CAP), thiamphenicol(TAP) and florphenicol(FF)) in foodstuff then determined by High Performance Liquid Chromatography (HPLC)-Diode array detector(DAD). Firstly, a magnetic silica-coated Fe3O4 microsphere(Fe3O4@SiO2) was synthetized by sol-gel method, then it was functionalized by amino groups through 3-Aminopropyltriethoxysilane (APTES) reagent to form Fe3O4@SiO2-NH2; Thirdly, the amino group on Fe3O4@SiO2-NH2 was transferred to carboxylic group via the succinic anhydride to form Fe3O4@SiO2-COOH...
June 12, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28628813/removal-of-antibiotics-during-the-anaerobic-digestion-of-pig-manure
#6
Lu Feng, Mònica Escolà Casas, Lars Ditlev Mørck Ottosen, Henrik Bjarne Møller, Kai Bester
Antibiotics are frequently used in animals to treat sickness and prevent infection especially in industrial meat production. Some of the antibiotics cannot be completely metabolized and, as an unavoidable result, are excreted and thus end up in manure which is then spread in the environment. Currently increasing amounts of manure is used in biogas production before spreading the residuals on agricultural fields. In this study, the removal patterns of sulfonamides (sulfadiazine, sulfamethizole, sulfamethoxazole) and macrolides (clarithromycin, erythromycin), as well as trimethoprim, were investigated during the anaerobic digestion of pig manure...
June 16, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28622639/an-investigation-into-the-rapid-removal-of-tetracycline-using-multilayered-graphene-phase-biochar-derived-from-waste-chicken-feather
#7
Huiqin Li, Jingtao Hu, Yue Meng, Jinhua Su, Xiaojing Wang
This study investigated the removal of tetracycline (TC) using multilayered graphene-phase biochar (MGB) derived from waste chicken feather. MGB was produced through a two-stage carbonization and KOH-activation method. MGB was characterized by scanning electron microscopy (SEM), transmission electron microscope (TEM), Fourier transform infrared (FT-IR), Raman spectra, Zeta potential and elemental analysis. Various chemical functional groups were demonstrated on the surface of MGB. MGB was featured by a very large BET surface area of 1838m(2)/g...
June 13, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28621933/structural-flexibility-of-an-inhibitor-overcomes-drug-resistance-mutations-in-staphylococcus-aureus-ftsz
#8
Junso Fujita, Yoko Maeda, Eiichi Mizohata, Tsuyoshi Inoue, Malvika Kaul, Ajit K Parhi, Edmond J LaVoie, Daniel S Pilch, Hiroyoshi Matsumura
In the effort to combat antibiotic resistance, inhibitors of the essential bacterial protein FtsZ have emerged as a promising new class of compounds with clinical potential. One such FtsZ inhibitor (TXA707) is associated with potent activity against clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA) that are resistant to current standard-of-care antibiotics. However, mutations in S. aureus FtsZ (SaFtsZ) that confer resistance to TXA707 have been observed, with mutations in the Gly196 and Gly193 residues being among the most prevalent...
June 16, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28621728/determination-of-sulfonamide-residues-in-food-by-capillary-zone-electrophoresis-with-on-line-chemiluminescence-detection-based-on-an-ag-iii-complex
#9
Tingting Dai, Jie Duan, Xinghua Li, Xiangdong Xu, Hongmei Shi, Weijun Kang
The presence of sulfonamide (SA) residues in foods is largely due to the raising of animals with sulfonamide antibiotics added or polluted feedstuff. In this paper, a sensitive method was developed for the determination of the residues of three sulfonamides in animal-derived food; the SAs include sulfadimidine (SDD), sulfadiazine (SDZ), and sulfathiazole (STZ). The method is based on capillary zone electrophoresis (CE) with online chemiluminescence (CL) detection, using an Ag(III) complex as an oxidant. These SAs have an inhibiting effect on the Ag(III)-luminol CL reaction...
June 16, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28620609/antibiotic-resistances-in-livestock-a-comparative-approach-to-identify-an-appropriate-regression-model-for-count-data
#10
Anke Hüls, Cornelia Frömke, Katja Ickstadt, Katja Hille, Johanna Hering, Christiane von Münchhausen, Maria Hartmann, Lothar Kreienbrock
Antimicrobial resistance in livestock is a matter of general concern. To develop hygiene measures and methods for resistance prevention and control, epidemiological studies on a population level are needed to detect factors associated with antimicrobial resistance in livestock holdings. In general, regression models are used to describe these relationships between environmental factors and resistance outcome. Besides the study design, the correlation structures of the different outcomes of antibiotic resistance and structural zero measurements on the resistance outcome as well as on the exposure side are challenges for the epidemiological model building process...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/28614439/residual-volume-in-vials-of-antibiotics-used-in-pediatrics
#11
Caroline Magna Pessoa Chaves, Carolina Martins Bezerra, Francisca Elisângela Teixeira Lima, Maria Vera Lúcia Moreira Leitão Cardoso, Said Gonçalves da Cruz Fonseca, Viviane Martins da Silva
OBJECTIVE: Quantifying residual volume contained in vials of antibiotics used in pediatrics. METHOD: This is an experiment involving samples from vials of antibiotics used in a pediatric hospital. Residual volume was identified by calculating the difference in weight measurement before and after the vials were washed. Evaluation of the residual volume difference in the vials was determined by the Wilcoxon non-parametric test for a sample and established at a significance level of 5%...
June 12, 2017: Revista da Escola de Enfermagem da U S P
https://www.readbyqxmd.com/read/28613873/the-drug-resistant-variant-p167s-expands-the-substrate-profile-of-ctx-m-%C3%AE-lactamases-for-oxyimino-cephalosporin-antibiotics-by-enlarging-the-active-site-upon-acylation
#12
Meha P Patel, Liya Hu, Vlatko Stojanoski, Banumathi Sankaran, B V Venkataram Prasad, Timothy Palzkill
β-Lactamases are enzymes produced by bacterial cells that provide resistance to β-lactam antibiotics. The CTX-M class of β-lactamases provides resistance against the antibiotic, cefotaxime, but not a related oxyimino-cephalosporin antibiotic, ceftazidime. β-lactamases that carry the P167S substitution, however, have been reported to provide ceftazidime resistance. The mechanism by which the P167S substitution expands the substrate profile of CTX-M enzymes is not known. In this study, CTX-M-14 was used as the model enzyme to study the structural changes caused by the P167S mutation that may accelerate ceftazidime turnover...
June 14, 2017: Biochemistry
https://www.readbyqxmd.com/read/28608621/simultaneous-extraction-and-determination-of-antibiotics-in-soils-using-a-method-based-on-quick-easy-cheap-effective-rugged-and-safe-extraction-and-liquid-chromatography-with-tandem-mass-spectrometry
#13
Minghui Meng, Zeying He, Yaping Xu, Lu Wang, Yi Peng, Xiaowei Liu
The increasing use of antibiotics has caused substantial environmental problems, which proved to be a matter of great concern. The aim of this work was to develop a quick, easy, cheap, effective, rugged and safe method for 20 antibiotics residues in soil. The developed method was based on extraction with acetonitrile and phosphate buffer, clean-up with dispersive solid-phase extraction adsorbent using primary secondary amine, octadecylsilane, followed by liquid chromatography with tandem mass spectrometry determination...
June 13, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28605496/validation-of-microbiological-testing-in-cardiovascular-tissue-banks-results-of-a-quality-round-trial
#14
Theo M M H de By, Carl McDonald, Susanne Süßner, Jill Davies, Wee Ling Heng, Ramadan Jashari, Ad J J C Bogers, Pieter Petit
OBJECTIVES: Surgeons needing human cardiovascular tissue for implantation in their patients are confronted with cardiovascular tissue banks that use different methods to identify and decontaminate micro-organisms. To elucidate these differences, we compared the quality of processing methods in 20 tissue banks and 1 reference laboratory. We did this to validate the results for accepting or rejecting tissue. We included the decontamination methods used and the influence of antibiotic cocktails and residues with results and controls...
June 12, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28602283/screening-method-for-the-detection-of-residues-of-amphenicol-antibiotics-in-bovine-ovine-and-porcine-kidney-by-optical-biosensor
#15
Colin S Thompson, Imelda M Traynor, Terence L Fodey, Dermot V Faulkner, Steven R H Crooks
An immunobiosensor assay was developed for the multi-residue screening of the parent amphenicols, thiamphenicol and florfenicol, along with the metabolite florfenicol amine, in bovine, ovine and porcine kidney. A polyclonal antiserum raised in a rabbit after inoculation with a florfenicol amine-protein conjugate was employed in the assay. Sample homogenates were extracted directly into acetonitrile, reconstituted in buffer and diluted prior to biosensor analysis. Validation data obtained from the analysis of fortified samples has shown that the method has a detection capability (CCβ) of less than 25µgkg(-1) (1/2 MRL) for thiamphenicol in the kidney of all three species, less than 150µgkg(-1)(1/2 MRL) for florfenicol and florfenicol amine and less than 250µgkg(-1) (1/2 MRL) for florfenicol and florfenicol amine in bovine/ovine and porcine kidney respectively...
September 1, 2017: Talanta
https://www.readbyqxmd.com/read/28601567/impact-of-evidence-based-interventions-on-wound-complications-after-cesarean
#16
Lorene A Temming, Nandini Raghuraman, Ebony B Carter, Molly J Stout, Roxane M Rampersad, George A Macones, Alison G Cahill, Methodius G Tuuli
BACKGROUND: A number of evidence-based interventions have been proposed to reduce post cesarean wound complications. Examples of such interventions include appropriate timing of preoperative antibiotics, appropriate choice of skin antisepsis, closure of the subcutaneous layer if subcutaneous depth is ≥ 2 cm, and subcuticular skin closure with suture rather than staples. However, the collective impact of these measures is unclear. OBJECTIVE: We sought to estimate the impact of a group of evidence-based surgical measures (prophylactic antibiotics administered prior to skin incision, chlorhexidine-alcohol for skin antisepsis, closure of subcutaneous layer, and subcuticular skin closure with suture) on wound complications after cesarean, and to estimate residual risk factors for wound complications...
June 7, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28597925/validation-of-a-procedure-to-quantify-oxolinic-acid-danofloxacin-ciprofloxacin-and-enrofloxacin-in-selected-meats-by-micellar-liquid-chromatography-according-to-eu-commission-decision-2002-657-ec
#17
Juan Peris-Vicente, Khaled Tayeb-Cherif, Samuel Carda-Broch, Josep Esteve-Romero
The suitability of an analytical method to determine oxolinic acid, danofloxacin, ciprofloxacin and enrofloxacin in edible tissues, based on micellar liquid chromatography coupled with fluorescence detection, to be applied in chicken, turkey, duck, lamb, goat, rabbit and horse muscle, is described. The method was fully matrix-matched in-lab revalidated, for each antimicrobial drug and meat, following the guidelines of the EU Commission Decision 2002/657/EC. The permitted limits were the maximum residue limits stated by the EU Commission Regulation 37/2010...
June 9, 2017: Electrophoresis
https://www.readbyqxmd.com/read/28593547/occurrence-and-human-dietary-assessment-of-sulfonamide-antibiotics-in-cultured-fish-around-tai-lake-china
#18
Chao Song, Le Li, Cong Zhang, Barry Kamira, Liping Qiu, Limin Fan, Wei Wu, Shunlong Meng, Gengdong Hu, Jiazhang Chen
As the most important fishery medicines, sulfonamides are widely used to prevent diseases caused by pathogens in aquaculture. However, relatively little is known about the residues and dietary risks associated with cultured fish around Tai Lake. In the present study, a sampling strategy for a complete aquaculture period was conducted. Specifically, 12 selected sulfonamide antibiotics were measured among 116 fish samples recruited from four sampling periods, four species, four areas, and 18 fish ponds. All 12 antibiotics were detected at detection frequencies of 4...
June 7, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28588003/pituitary-adenoma-apoplexy-in-an-adolescent-a-case-report-and-review-of-the-literature
#19
Hero Zijlker, Sebastian Schagen, Jan Maarten Wit, Biermasz Nienke, Wouter van Furth, Wilma Oostdijk
We present a 13-year-old boy who became progressively sleepy and experienced a sudden headache with vomiting and fever. Laboratory testing showed hypoglycemia, multiple pituitary hormonal deficiencies and elevated C-Reactive Protein (CRP). A cranial MRI showed an opaque sphenoid sinus and an intrasellar mass suspect for hemorrhage, so that we suspected a pituitary apoplexy (PA) originating from a non-functioning adenoma, although a pituitary abscess could not completely be excluded. The boy was treated with antibiotics, hydrocortisone and levothyroxine and a close follow-up to monitor the clinical course...
June 7, 2017: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/28587735/the-invasive-menc-cc103-lineage-with-penicillin-reduced-susceptibility-persisting-in-brazil
#20
Érica L Fonseca, Michel A Marin, Fernanda S Freitas, Bruna S A Vitório, Flávio M G de Araújo, Dhian R A Camargo, Roney S Coimbra, Ivano R De Filippis, Ana Carolina P Vicente
Penicillin is the antibiotic of choice for the treatment of meningococcal infections, and mutations in penA gene are involved with reduced susceptibility (pen(I)) emergence to this antibiotic. This study aimed to characterize the penA allelic diversity, their association with pen(I) phenotype and distribution among prevalent meningococci serogroups in Brazil. The entire penA from 49 invasive strains of distinct serogroups circulating in Brazil for more than two decades were obtained by PCR and sequencing. Additionally, the penA from 22 publicly available complete Neisseria meningitidis genomes from Brazil were included in the study...
May 25, 2017: International Journal of Medical Microbiology: IJMM
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