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https://www.readbyqxmd.com/read/28727585/closed-continuous-irrigation-with-lidocaine-and-immediate-mobilization-for-treatment-of-pyogenic-tenosynovitis
#1
Rebecca Knackstedt, Joyce Tyler, Steven Bernard
Pyogenic flexor tenosynovitis treatment consists of either closed continuous irrigation with sterile saline or antibiotic solution, or open debridement and irrigation. These treatment approaches serve to resolve the infection, but are extremely painful and residual stiffness can be devastating to the patient. We describe herein our approach to managing pyogenic flexor tenosynovitis. To provide continuous irrigation, a butterfly catheter with needle removed is utilized with irrigation holes cut into the tubing...
July 19, 2017: Techniques in Hand & Upper Extremity Surgery
https://www.readbyqxmd.com/read/28724222/development-of-a-soft-extraction-method-for-sulfamethoxazole-and-transformation-products-from-agricultural-soils-effects-of-organic-matter-co-extraction-on-the-environmental-availability-assessment
#2
Anaïs Goulas, Marjolaine Bourdat-Deschamps, Sylvie Nélieu, Julie Jimenez, Dominique Patureau, Claire-Sophie Haudin, Pierre Benoit
The recycling of biosolids and livestock manure in agriculture may lead to the introduction of antibiotic residues, i.e., parent molecule and transformation products, into amended soils. Their fate in soils can be approached through the assessment of their environmental availability. In this work, the environmental availability of sulfamethoxazole (SMX) and three transformation products (N(4)-acetyl-SMX, 3-amino-5-methylisoxazole, aniline) was assessed in soils amended with sludge compost or cow manure throughout a three-month incubation, using soft extractions with CaCl2, EDTA or cyclodextrin solutions...
July 14, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28721044/stimulated-phase-shift-acoustic-nanodroplets-enhance-vancomycin-efficacy-against-methicillin-resistant-staphylococcus-aureus-biofilms
#3
Hao Guo, Ziming Wang, Quanyin Du, Pan Li, Zhigang Wang, Aimin Wang
PURPOSE: Bacterial biofilms on the surface of prostheses are becoming a rising concern in managing prosthetic joint infections. The inherent resistant features of biofilms render traditional antimicrobial therapy unproductive and revision surgery outcomes uncertain. This situation has prompted the exploration of novel antimicrobial strategies. The synergy of ultrasound microbubbles and vancomycin has been proposed as an efficient alternative for biofilm eradication. The purpose of this study was to evaluate the anti-biofilm effect of stimulated phase-shift acoustic nanodroplets (NDs) combined with vancomycin...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28720734/lack-of-acrb-efflux-function-confers-loss-of-virulence-on-salmonella-enterica-serovar-typhimurium
#4
Xuan Wang-Kan, Jessica M A Blair, Barbara Chirullo, Jonathan Betts, Roberto M La Ragione, Alasdair Ivens, Vito Ricci, Timothy J Opperman, Laura J V Piddock
AcrAB-TolC is the paradigm resistance-nodulation-division (RND) multidrug resistance efflux system in Gram-negative bacteria, with AcrB being the pump protein in this complex. We constructed a nonfunctional AcrB mutant by replacing D408, a highly conserved residue essential for proton translocation. Western blotting confirmed that the AcrB D408A mutant had the same native level of expression of AcrB as the parental strain. The mutant had no growth deficiencies in rich or minimal medium. However, compared with wild-type SL1344, the mutant had increased accumulation of Hoechst 33342 dye and decreased efflux of ethidium bromide and was multidrug hypersusceptible...
July 18, 2017: MBio
https://www.readbyqxmd.com/read/28712635/efficacy-of-xp-endo-finisher-in-the-removal-of-triple-antibiotic-paste-from-immature-root-canals
#5
Dilek Turkaydin, Erhan Demir, Fatima Betul Basturk, Hesna Sazak Övecoglu
INTRODUCTION: The aim of this study was to evaluate and compare the effectiveness of the XP-Endo Finisher (FKG Dentaire, La Chaux-de-Fonds, Switzerland) with passive ultrasonic irrigation (PUI) and needle irrigation in the removal of triple antibiotic paste (TAP) from the straight immature root canals of extracted teeth. METHODS: Thirty-four freshly extracted single-rooted teeth were used. All canals were prepared up to the ProTaper F5 file (Dentsply Maillefer, Ballaigues, Switzerland)...
July 13, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28711002/effect-of-temperature-on-sulfonamide-antibiotics-degradation-and-on-antibiotic-resistance-determinants-and-hosts-in-animal-manures
#6
Hui Lin, Jin Zhang, Hongjin Chen, Jianmei Wang, Wanchun Sun, Xin Zhang, Yuyi Yang, Qiang Wang, Junwei Ma
Animal manure is a main reservoir of antibiotic residues and antibiotic resistance. Here, the effect of temperature on sulfonamide antibiotics (SAs), sulfonamide-resistant (SR) genes/bacteria was investigated by aerobically incubating swine and chicken manures at different temperatures. In swine manure, the SAs concentration declined with increasing temperature, with a minimum at 60°C. In chicken manure, the greatest degradation of SAs was noted at 30°C. The reduction of relative abundance of antibiotic resistance genes (ARGs) and sul-positive hosts in swine manure was more pronounced during thermophilic than mesospheric incubation; neither temperature conditions effectively reduced these parameters in chicken manure...
July 12, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28709370/sewers-as-potential-reservoirs-of-antibiotic-resistance
#7
Olga Auguet, Maite Pijuan, Carles M Borrego, Sara Rodriguez-Mozaz, Xavier Triadó-Margarit, Saulo Varela Della Giustina, Oriol Gutierrez
Wastewater transport along sewers favors the colonization of inner pipe surfaces by wastewater-derived microorganisms that grow forming biofilms. These biofilms are composed of rich and diverse microbial communities that are continuously exposed to antibiotic residues and antibiotic resistant bacteria (ARB) from urban wastewater. Sewer biofilms thus appear as an optimal habitat for the dispersal and accumulation of antibiotic resistance genes (ARGs). In this study, the concentration of antibiotics, integron (intI1) and antibiotic resistance genes (qnrS, sul1, sul2, blaTEM, blaKPC, ermB, tetM and tetW), and potential bacterial pathogens were analyzed in wastewater and biofilm samples collected at the inlet and outlet sections of a pressurized sewer pipe...
July 10, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28705754/progression-of-lyme-disease-to-bell-s-palsy-despite-treatment-with-doxycycline
#8
Luis A Marcos, Zengmin Yan
A 54 year-old healthy woman presented to the emergency department with a right sided facial paralysis. About 3 weeks ago, she woke up and noticed an attached engorged tick in her right lower extremity. A week later, she noticed a mild to moderate right jaw pain which progressed to a severe right facial pain so she visited her doctor. On physical, II to XII cranial nerve examination was unremarkable. Doppler ultrasound did not show any vascular abnormalities in temporal artery. Her inflammatory markers were within normal limits (C-reactive protein:0...
July 10, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28704043/structural-insights-into-thioether-bond-formation-in-the-biosynthesis-of-sactipeptides
#9
Tyler L Grove, Paul Michael Himes, Sungwon Hwang, Hayretin Yumerefendi, Jeffrey B Bonanno, Brian Kuhlman, Steven C Almo, Albert A Bowers
Sactipeptides are ribsomally-produced peptides that contain a characteristic thioether bridge (sactionine bond) that is installed posttranslationally and is absolutely required for their antibiotic activity. Sactipeptide biosynthesis requires a unique class of radical SAM enzymes that contain multiple [4Fe-4S] clusters to form the requisite thioether bridge between a cysteine and the α-carbon of an opposing amino acid through radical chemistry. Here we present the structure of the sactionine bond forming enzyme CteB, from Clostridium thermocellum ATCC 27405, with both SAM and an N-terminal fragment of it's peptidyl-substrate at 2...
July 13, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28702543/accelerated-molecular-dynamics-simulation-analysis-of-msi-594-in-a-lipid-bilayer
#10
Shruti Mukherjee, Rajiv K Kar, Ravi Prakash Reddy Nanga, Kamal H Mroue, Ayyalusamy Ramamoorthy, Anirban Bhunia
Multidrug resistance against the existing antibiotics is one of the most challenging threats across the globe. Antimicrobial peptides (AMPs), in this regard, are considered to be one of the effective alternatives that can overcome bacterial resistance. MSI-594, a 24-residue linear alpha-helical cationic AMP, has been shown to function via the carpet mechanism to disrupt bacterial membrane systems. To better understand the role of lipid composition in the function of MSI-594, in the present study, eight different model membrane systems have been studied using accelerated molecular dynamics (aMD) simulations...
July 13, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28701197/a-case-of-bowel-perforation-due-to-traumatic-hernia-at-a-pelvic-fracture-site-a-case-report-and-review-of-the-literature
#11
Ryota Tanaka, Hisashi Nagahara, Kiyoshi Maeda, Hiroshi Ohtani, Masatsune Shibutani, Tatsuro Tamura, Tetsuro Ikeya, Kenji Sugano, Yasuhito Iseki, Katsunobu Sakurai, Sadaaki Yamazoe, Kenjiro Kimura, Takahiro Toyokawa, Ryosuke Amano, Naoshi Kubo, Hiroaki Tanaka, Kazuya Muguruma, Kosei Hirakawa, Masaichi Ohira
BACKGROUND: Common complications of pelvic fractures include visceral injury, large-volume hemorrhage, genitourinary injury, rectal injury, and pulmonary embolism. On the other hand, traumatic hernia is a rare complication, especially in association with pelvic fractures. We report a case of bowel perforation due to traumatic hernia at a pelvic fracture site. CASE PRESENTATION: A 65-year-old female was presented at our hospital for further examination and treatment of ileus...
July 12, 2017: BMC Surgery
https://www.readbyqxmd.com/read/28700825/chemical-visualization-of-sweat-pores-in-fingerprints-using-go-enhanced-tof-sims
#12
Lesi Cai, Mengchan Xia, Zhaoying Wang, Ya-Bin Zhao, Zhanping Li, Sichun Zhang, Xinrong Zhang
Time-of-flight secondary ion mass spectrometry (TOF-SIMS) has been used in imaging of small molecules (< 500 Da) in fingerprints, such as gunshot residues and illicit drugs. However, identifying and mapping relatively high mass molecules are quite difficult owing to insufficient ion yield of their molecular ions. In this report, Graphene oxide(GO)-enhanced TOF-SIMS was used to detect and image relatively high mass molecules such as poison, alkaloids (> 600 Da) and controlled drugs, antibiotics (> 700 Da) in fingerprints...
July 12, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28698980/the-combined-effects-of-the-provision-of-feed-and-healthcare-on-nutrient-utilization-and-growth-performance-of-sheep-during-the-early-or-late-dry-season
#13
Solomon P Konlan, Augustine Ayantunde, Weseh Addah, Herbert H K Dei
An on-farm study was conducted to determine the combined effects of the provision of feed and healthcare on nutrient use and growth performance of sheep during the early or late dry season. A total of 36 smallholder sheep farmers with a flock size of ≤7 was randomly selected within each of the three administrative regions in Northern Ghana. The sheep grazed on a heterogeneous natural pasture and offered crop residues as basal diet (control) or were additionally provided with a concentrate feed plus orthodox healthcare to control diseases and pests (CH) in a completely randomized block design...
July 11, 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/28693993/probing-the-interaction-of-cephalosporin-antibiotic-ceftazidime-with-human-serum-albumin-a-biophysical-investigation
#14
Mohammad Khursheed Siddiqi, Parvez Alam, Sumit Kumar Chaturvedi, Saima Nusrat, Mohammad Rehan Ajmal, Ali Saber Abdelhameed, Rizwan Hasan Khan
The fate of drug administered to a living organism depends on drug's pharmacokinetics as well as pharmacological behavior. Serum albumins (proteins in blood plasma of human) act as a carrier molecule to deliver the drug at specific site. In the present study, we have explored the mechanism of interaction between cephalosporin antibiotic - ceftazidime (CFD) and human serum albumin (HSA) by spectroscopic and molecular docking studies. Quenching of HSA fluorescence by CFD inferred that it binds to HSA through static quenching mechanism; with binding affinity in order of 10(4)M(-1)...
July 7, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28692897/fate-and-impacts-of-pharmaceuticals-and-personal-care-products-after-repeated-applications-of-organic-waste-products-in-long-term-field-experiments
#15
Marjolaine Bourdat-Deschamps, Sabrina Ferhi, Nathalie Bernet, Fréderic Feder, Olivier Crouzet, Dominique Patureau, Denis Montenach, Géraud D Moussard, Vincent Mercier, Pierre Benoit, Sabine Houot
Recycling organic waste products in agriculture is a potential route for the dispersion of pharmaceutical residues in the environment. In this study, the concentrations of thirteen pharmaceuticals and the personal care product triclosan (PPCPs) were determined in different environmental matrices from long-term experimental fields amended with different organic waste products (OWPs), including sludge, composted sludge with green wastes, livestock effluents and composted urban wastes applied at usual agricultural rates...
July 7, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28692281/structural-and-biophysical-characterization-of-the-mycobacterium-tuberculosis-protein-rv0577-a-protein-associated-with-neutral-red-staining-of-virulent-tuberculosis-strains-and-homolog-of-the-streptomyces-coelicolor-protein-kbpa
#16
Garry W Buchko, Nathanial Echols, E Megan Flynn, Ho Ng, Sam Stephenson, Heung-Bok Kim, Peter J Myler, Thomas C Terwilliger, Tom Alber, Chang-Yub Kim
The 261-residue Mycobacterium tuberculosis protein Rv0577 is a prominent antigen in tuberculosis patients, the responsible component for neutral red staining of virulent strains of M. tuberculosis, a putative component in a methylglyoxal detoxification pathway, and an agonist of toll-like receptor 2. It also has 36% amino acid sequence identity to Streptomyces coelicolor AfsK-binding protein A (KbpA), a component in the complex secondary metabolite pathways in the Streptomycetes genus from which many commercial antibiotics are derived...
July 10, 2017: Biochemistry
https://www.readbyqxmd.com/read/28691656/mutational-analysis-of-the-ms2-lysis-protein-l
#17
Karthik R Chamakura, Garrett B Edwards, Ry Young
Small single-stranded nucleic acid phages effect lysis by expressing a single protein, the amurin, lacking muralytic enzymatic activity. Three amurins have been shown to act like 'protein antibiotics' by inhibiting cell-wall biosynthesis. However, the L lysis protein of the canonical ssRNA phage MS2, a 75 aa polypeptide, causes lysis by an unknown mechanism without affecting net peptidoglycan synthesis. To identify residues important for lytic function, randomly mutagenized alleles of L were generated, cloned into an inducible plasmid and the transformants were selected on agar containing the inducer...
July 8, 2017: Microbiology
https://www.readbyqxmd.com/read/28689415/thermophilic-enzyme-or-mesophilic-enzyme-with-enhanced-thermostability-can-we-draw-a-line
#18
Xiaomin Jing, Wilfredo Evangelista Falcón, Jerome Yves Baudry, Engin H Serpersu
The aminoglycoside nucleotidyltransferase 4' (ANT) is a homodimeric enzyme that modifies the C4'-OH site of aminoglycoside antibiotics by nucleotidylation. A few single and double residue mutants of this enzyme (T130K, D80Y and D80Y/T130K) from Bacillus stearothermophilus show increased thermostability. This paper investigates how such residue replacements, which are distant from active site and monomer-monomer interface, result in various changes of the thermostability of the enzyme. In this work, we show that thermodynamic properties of enzyme-ligand complexes and protein dynamics may be indicators of thermophilic behavior...
July 8, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28689129/the-potential-implications-of-reclaimed-wastewater-reuse-for-irrigation-on-the-agricultural-environment-the-knowns-and-unknowns-of-the-fate-of-antibiotics-and-antibiotic-resistant-bacteria%C3%A2-and-resistance-genes-a-review
#19
REVIEW
Anastasis Christou, Ana Agüera, Josep Maria Bayona, Eddie Cytryn, Vasileios Fotopoulos, Dimitra Lambropoulou, Célia M Manaia, Costas Michael, Mike Revitt, Peter Schröder, Despo Fatta-Kassinos
The use of reclaimed wastewater (RWW) for the irrigation of crops may result in the continuous exposure of the agricultural environment to antibiotics, antibiotic resistant bacteria (ARB) and antibiotic resistance genes (ARGs). In recent years, certain evidence indicate that antibiotics and resistance genes may become disseminated in agricultural soils as a result of the amendment with manure and biosolids and irrigation with RWW. Antibiotic residues and other contaminants may undergo sorption/desorption and transformation processes (both biotic and abiotic), and have the potential to affect the soil microbiota...
July 3, 2017: Water Research
https://www.readbyqxmd.com/read/28677513/-a-teenage-girl-with-non-infectious-osteomyelitis
#20
A C Deden, P Hissink Muller, N M Appelman-Dijkstra, H M Kroon, G A Tramper-Stranders
BACKGROUND: Osteomyelitis is usually caused by an infection. A non-infectious cause should be considered if antibiotic treatment is insufficiently effective and disease is recurrent, multifocal or migrating. CASE DESCRIPTION: A 14-year-old girl, an active volleyball player, developed episodes of fever and pain in her right lower leg. MRI showed osteomyelitis in her right tibia. She received prolonged intravenous antibiotic treatment. Shortly after recovery, she developed osteomyelitis in her left lower leg...
2017: Nederlands Tijdschrift Voor Geneeskunde
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