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https://www.readbyqxmd.com/read/29683892/implication-of-highly-cytotoxic-natural-killer-cells-for-esophageal-squamous-cell-carcinoma-treatment
#1
Kee Siang Lim, Kosaku Mimura, Ley-Fang Kua, Kensuke Shiraishi, Koji Kono
Esophageal squamous cell carcinoma (ESCC) is an aggressive upper gastrointestinal cancer and effective treatments are limited. Previous studies reported that natural killer (NK) cells expanded by coculturing with K562-mb15-41BBL feeder cells, a genetically modified K562 leukemia cell line that expresses membrane-bound interleukin (IL)-15 and 41BBL ligand, were highly proliferative and highly cytotoxic. Here, we investigated the potential of expanded NK cells for ESCC treatment. We analyzed both genetic and surface expression levels of NKG2D ligands (NKG2DLs) in ESCC using publicly available microarray data sets and ESCC cell lines...
April 20, 2018: Journal of Immunotherapy
https://www.readbyqxmd.com/read/29680200/biological-feasibility-and-importance-of-a-gonorrhea-vaccine-for-global-public-health
#2
Leah R Vincent, Ann E Jerse
There is a growing public health interest in controlling sexually transmitted infections (STIs) through vaccination due to increasing recognition of the global disease burden of STIs and the role of STIs in women's reproductive health, adverse pregnancy outcomes, and the health and well-being of neonates. Neisseria gonorrhoeae has historically challenged vaccine development through the expression of phase and antigenically variable surface molecules and its capacity to cause repeated infections without inducing protective immunity...
April 18, 2018: Vaccine
https://www.readbyqxmd.com/read/29678884/physiological-temperatures-reduce-dimerization-of-dengue-and-zika-virus-recombinant-envelope-proteins
#3
Stephan T Kudlacek, Lakshmanane Premkumar, Stefan W Metz, Ashutosh Tripathy, Andrey A Bobkov, Alexander Matthew Payne, Stephen Graham, James A Brackbill, Michael J Miley, Aravinda M de Silva, Brian Kuhlman
The spread of dengue (DENV) and Zika virus (ZIKV) is a major public health concern. The primary target of antibodies (Abs) that neutralize DENV and ZIKV is the envelope (E) glycoprotein, and there is interest in using soluble recombinant E (sRecE) proteins as subunit vaccines. However, the most potent neutralizing antibodies against DENV and ZIKV recognize epitopes on the virion surface that span two or more E proteins. Therefore, to create effective DENV and ZIKV vaccines, presentation of these quaternary epitopes may be necessary...
April 20, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29678324/time-series-study-of-weather-water-quality-and-acute-gastroenteritis-at-water-safety-plan-implementation-sites-in-france-and-spain
#4
Karen E Setty, Jerome Enault, Jean-Francois Loret, Claudia Puigdomenech Serra, Jordi Martin-Alonso, Jamie Bartram
Water Safety Plans (WSPs), recommended by the World Health Organization since 2004, can help drinking water suppliers to proactively identify potential risks and implement preventive barriers that improve safety. Few studies have investigated long-term impacts of WSPs, such as changes in drinking water quality or public health; however, some evidence from high-income countries associates WSP implementation with a reduction in diarrheal disease. To validate the previously observed linkages between WSPs and health outcomes, this time series study examined site-specific relationships between water-related exposures and acute gastroenteritis rates at three locations in France and Spain, including the role of WSP status...
April 6, 2018: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/29676643/climate-change-and-implications-for-prevention-california-s-efforts-to-provide-leadership
#5
John R Balmes
The atmospheric concentration of carbon dioxide (CO2 ) and the temperature of the earth's surface have been rising in parallel for decades, with the former recently reaching 400 parts per million, consistent with a 1.5°C increase in global warming. Climate change models predict that a "business as usual" approach, that is, no effort to control CO2 emissions from combustion of fossil fuels, will result in a more than 2°C increase in annual average surface temperature by approximately 2034. With atmospheric warming comes increased air pollution...
April 2018: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29673966/automated-search-of-control-points-in-surface-based-morphometry
#6
Antonietta Canna, Andrea G Russo, Sara Ponticorvo, Renzo Manara, Alessandro Pepino, Mario Sansone, Francesco Di Salle, Fabrizio Esposito
Cortical surface-based morphometry is based on a semi-automated analysis of structural MRI images. In FreeSurfer, a widespread tool for surface-based analyses, a visual check of gray-white matter borders is followed by the manual placement of control points to drive the topological correction (editing) of segmented data. A novel algorithm combining radial sampling and machine learning is presented for the automated control point search (ACPS). Four data sets with 3 T MRI structural images were used for ACPS validation, including raw data acquired twice in 36 healthy subjects and both raw and FreeSurfer preprocessed data of 125 healthy subjects from public databases...
April 16, 2018: NeuroImage
https://www.readbyqxmd.com/read/29673302/disjunctures-in-experiences-of-support-during-the-transition-to-fatherhood-of-men-who-have-used-intimate-partner-violence
#7
Juliana Carlson, Erin Casey
The transition to fatherhood has been shown to be a stressful time for men, and their experiences of identifying and accessing formal and informal support are mixed. However, research on the experience of men who use intimate partner violence (IPV) during the transition to fatherhood is limited. The evidence documenting the prevalence and short- and long-term impact of violence perpetrated by men against women during pregnancy and postpartum demonstrates the seriousness of this public health issue. To understand the mechanisms of interrupting IPV by engaging men, the gap between what is known about experiences of identifying the need for and access to support during the transition to fatherhood of men with past and current histories of using IPV must be bridged...
April 1, 2018: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29670543/phosphoinositide-3-kinase-signaling-pathway-in-pancreatic-ductal-adenocarcinoma-progression-pathogenesis-and-therapeutics
#8
REVIEW
Divya Murthy, Kuldeep S Attri, Pankaj K Singh
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy characterized by its sudden manifestation, rapid progression, poor prognosis, and limited therapeutic options. Genetic alterations in key signaling pathways found in early pancreatic lesions are pivotal for the development and progression of pancreatic intraepithelial neoplastic lesions into invasive carcinomas. More than 90% of PDAC tumors harbor driver mutations in K-Ras that activate various downstream effector-signaling pathways, including the phosphoinositide-3-kinase (PI3K) pathway...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29664205/selective-and-sensitive-escherichia-coli-detection-based-on-a-t4-bacteriophage-immobilized-multimode-microfiber
#9
Yanpeng Li, Hui Ma, Lin Gan, Andong Gong, Haibin Zhang, Deming Liu, Qizhen Sun
Escherichia coli (E.coli) bacteria have been found to be responsible for various health outbreaks caused by contaminated food and water. Accurate and rapid test of E.coli is thus crucial for protecting the public health. A fast-response, label-free bacteriophage-based detection of E.coli using multimode microfiber probe is proposed and demonstrated in this paper. Due to the abrupt taper and subwavelength diameter, different modes are excited and guided in the microfiber as evanescent field that can interact with surrounding E...
April 17, 2018: Journal of Biophotonics
https://www.readbyqxmd.com/read/29662248/internet-blogs-polar-bears-and-climate-change-denial-by-proxy
#10
Jeffrey A Harvey, Daphne van den Berg, Jacintha Ellers, Remko Kampen, Thomas W Crowther, Peter Roessingh, Bart Verheggen, Rascha J M Nuijten, Eric Post, Stephan Lewandowsky, Ian Stirling, Meena Balgopal, Steven C Amstrup, Michael E Mann
Increasing surface temperatures, Arctic sea-ice loss, and other evidence of anthropogenic global warming (AGW) are acknowledged by every major scientific organization in the world. However, there is a wide gap between this broad scientific consensus and public opinion. Internet blogs have strongly contributed to this consensus gap by fomenting misunderstandings of AGW causes and consequences. Polar bears (Ursus maritimus) have become a "poster species" for AGW, making them a target of those denying AGW evidence...
April 1, 2018: Bioscience
https://www.readbyqxmd.com/read/29662110/identification-of-human-glycosyltransferase-genes-expressed-in-erythroid-cells-predicts-potential-carbohydrate-blood-group-loci
#11
Magnus Jöud, Mattias Möller, Martin L Olsson
Glycans are biologically important structures synthesised by glycosyltransferase (GT) enzymes. Disruptive genetic null variants in GT genes can lead to serious illness but benign phenotypes are also seen, including antigenic differences on the red blood cell (RBC) surface, giving rise to blood groups. To characterise known and potential carbohydrate blood group antigens without a known underlying gene, we searched public databases for human GT loci and investigated their variation in the 1000 Genomes Project (1000 G)...
April 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29661000/regulation-of-clathrin-mediated-endocytosis
#12
Marcel Mettlen, Ping-Hung Chen, Saipraveen Srinivasan, Gaudenz Danuser, Sandra L Schmid
Clathrin-mediated endocytosis (CME) is the major endocytic pathway in mammalian cells. It is responsible for the uptake of transmembrane receptors and transporters, for remodeling plasma membrane composition in response to environmental changes, and for regulating cell surface signaling. CME occurs via the assembly and maturation of clathrin-coated pits that concentrate cargo as they invaginate and pinch off to form clathrin-coated vesicles. In addition to the major coat proteins, clathrin triskelia and adaptor protein complexes, CME requires a myriad of endocytic accessory proteins and phosphatidylinositol lipids...
April 16, 2018: Annual Review of Biochemistry
https://www.readbyqxmd.com/read/29659976/a-novel-radiation-shielding-undergarment-using-tungsten-functional-paper-for-patients-with-permanent-prostate-brachytherapy
#13
Masahiro Inada, Hajime Monzen, Kenji Matsumoto, Mikoto Tamura, Takafumi Minami, Kiyoshi Nakamatsu, Yasumasa Nishimura
Tungsten functional paper (TFP) is a paper-based radiation-shielding material, which is lead-free and easy to cut. We developed a radiation protection undergarment using TFP for prostate cancer patients treated with permanent 125I seed implantation (PSI). The aim of this study was to evaluate the shielding ability of the undergarment with respect to household contacts and members of the public. Between October 2016 and April 2017, a total of 10 prostate cancer patients treated with PSI were enrolled in this prospective study...
April 11, 2018: Journal of Radiation Research
https://www.readbyqxmd.com/read/29656192/in-vitro-bioanalysis-of-drinking-water-from-source-to-tap
#14
Anna Kjerstine Rosenmai, Johan Lundqvist, Théo le Godec, Åsa Ohlsson, Rikard Tröger, Björn Hellman, Agneta Oskarsson
The presence of chemical pollutants in sources of drinking water is a key environmental problem threatening public health. Efficient removal of pollutants in drinking water treatment plants (DWTPs) is needed as well as methods for assessment of the total impact of all present chemicals on water quality. In the present study we have analyzed the bioactivity of water samples from source to tap, including effects of various water treatments in a DWTP, using a battery of cell-based bioassays, covering health-relevant endpoints...
April 6, 2018: Water Research
https://www.readbyqxmd.com/read/29656063/updates-on-antibody-functions-in-mycobacterium-tuberculosis-infection-and-their-relevance-for-developing-a-vaccine-against-tuberculosis
#15
REVIEW
Jacqueline M Achkar, Rafael Prados-Rosales
A more effective vaccine to control tuberculosis (TB), a major global public health problem, is urgently needed. Current vaccine candidates focus predominantly on eliciting cell-mediated immunity but other arms of the immune system also contribute to protection against TB. We review here recent studies that enhance our current knowledge of antibody-mediated functions against Mycobacterium tuberculosis. These findings, which contribute to the increasing evidence that antibodies have a protective role against TB, include demonstrations that firstly distinct human antibody Fc glycosylation patterns, found in latent M...
April 12, 2018: Current Opinion in Immunology
https://www.readbyqxmd.com/read/29655806/is-there-a-role-for-intervention-radiology-for-the-treatment-of-lower-limb-deep-vein-thrombosis-in-the-era-of-direct-oral-anticoagulants-a-comprehensive-review
#16
REVIEW
Marco Marietta, Elisa Romagnoli, Benilde Cosmi, Valeria Coluccio, Mario Luppi
Despite recent advances in the treatment of Deep Vein Thrombosis (DVT) provided by Direct Oral Anticoagulants (DOAC), a substantial proportion of lower limb DVT patients will develop some degree of post-thrombotic syndrome (PTS) within 2 years. Systemic thrombolysis, although effective in reducing the risk of PTS and leg ulceration, is associated with a high risk of major bleeding, making it unsuitable for the vast majority of patients. A local approach, aimed at delivering the fibrinolytic drug directly into, or near to, the thrombus surface, is attractive because of the possibility of lowering of the administered drug dose, thus reducing the bleeding risks...
April 11, 2018: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/29651636/aflatoxin-m-1-detoxification-ability-of-probiotic-lactobacilli-of-indian-origin-in-in-vitro-digestion-model
#17
Rohit Panwar, Narendra Kumar, Vipul Kashyap, Chand Ram, Rajeev Kapila
Aflatoxin M1 (AFM1 ) is known to be a potent carcinogen and continues to pose a public health concern through the consumption of contaminated dairy foods. It is anticipated that consumption of lactic acid bacteria capable of binding aflatoxins can reduce the risk of AFM1 on human health to a certain extent. Seldom reports have hinted the possibility of using lactic acid bacteria for the biological detoxification of AFM1 . Hence, the present study was conducted to assess the ability of selected probiotic Lactobacillus strains for their AFM1 binding ability in PBS and to reduce its bioaccessibility in artificially contaminated skim milk using an in vitro digestion model...
April 12, 2018: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/29643593/characteristics-associated-with-freezing-of-gait-in-actual-daily-living-in-parkinson-s-disease
#18
Mitsuaki Ishii, Kohei Okuyama
[Purpose] Parkinson's disease (PD) patients often freeze in actual daily living but seldom in clinical setting. This study aimed to identify the factors contributing to freezing of gait (FOG). [Subjects and Methods] The participants included 28 adults with PD. Principal component analysis was used to investigate the characteristics of 14 common FOG situations adopted from previous studies. Cluster analysis classified the subjects into four groups. Kruskal-Wallis test was performed to compare the PD Questionnaire-39 mobility dimension between the groups...
December 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/29643164/complications-in-breast-augmentation-with-textured-versus-smooth-breast-implants-a-systematic-review-protocol
#19
Chenglong Wang, Jie Luan, Adriana C Panayi, Dennis P Orgill, Minqiang Xin
INTRODUCTION: Breast augmentation is one of the most popular aesthetic plastic surgeries worldwide. There are various types of breast implants, and these can be categorised into different broad groups based on their content, shape or surface, to name a few. When looking at the surface of the shell, they can be categorised into two main kinds: textured and smooth implants. To our knowledge, a literature review and meta-analysis of the complications of these two types of implants when used for aesthetic breast augmentation has yet to be written...
April 10, 2018: BMJ Open
https://www.readbyqxmd.com/read/29642605/abundances-of-clinically-relevant-antibiotic-resistance-genes-and-bacterial-community-diversity-in-the-weihe-river-china
#20
Xiaojuan Wang, Jie Gu, Hua Gao, Xun Qian, Haichao Li
The spread of antibiotic resistance genes in river systems is an emerging environmental issue due to their potential threat to aquatic ecosystems and public health. In this study, we used droplet digital polymerase chain reaction (ddPCR) to evaluate pollution with clinically relevant antibiotic resistance genes (ARGs) at 13 monitoring sites along the main stream of the Weihe River in China. Six clinically relevant ARGs and a class I integron-integrase ( intI1 ) gene were analyzed using ddPCR, and the bacterial community was evaluated based on the bacterial 16S rRNA V3-V4 regions using MiSeq sequencing...
April 10, 2018: International Journal of Environmental Research and Public Health
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