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https://www.readbyqxmd.com/read/29928832/amalgam-alternatives-cost-effectiveness-and-value-of-information-analysis
#1
F Schwendicke, G Göstemeyer, M Stolpe, J Krois
We aimed to assess the cost-effectiveness of amalgam alternatives-namely, incrementally placed composites (IComp), composites placed in bulk (BComp), and glass ionomer cements (GIC). In a sensitivity analysis, we also included composite inlays (CompI) and incrementally placed bulk-fills (IBComp). Moreover, the value of information (VOI) regarding the effectiveness of all strategies was determined. A mixed public-private-payer perspective in the context of Germany was adopted. Bayesian network meta-analyses were performed to yield effectiveness estimates (relative risk [RR] of failure)...
June 1, 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/29927716/identification-of-a-novel-splice-variant-of-neural-cell-adhesion-molecule-in-glioblastoma-through-proteogenomics-analysis
#2
Savita Jayaram, Lavanya Balakrishnan, Manika Singh, Azin Zabihi, Raksha A Ganesh, Kiran K Mangalaparthi, Pranali Sonpatki, Manoj Kumar Gupta, Chaitra B Amaresha, Komal Prasad, Kiran Mariswamappa, Shibu Pillai, Akhila Lakshmikantha, Nameeta Shah, Ravi Sirdeshmukh
Splice variants are known to be important in the pathophysiology of tumors, including the brain cancers. We applied a proteogenomics pipeline to identify splice variants in glioblastoma (GBM, grade IV glioma), a highly malignant brain tumor, using in-house generated mass spectrometric proteomic data and public domain RNASeq dataset. Our analysis led to the identification of a novel exon that maps to the long isoform of Neural cell adhesion molecule 1 (NCAM1), expressed on the surface of glial cells and neurons, important for cell adhesion and cell signaling...
June 2018: Omics: a Journal of Integrative Biology
https://www.readbyqxmd.com/read/29926886/the-geospatial-relationship-of-pterygium-and-senile-cataract-with-ambient-solar-ultraviolet-in-tropical-ecuador
#3
Daniel R Garźon-Chavez, Emmanuelle Quentin, Simone L Harrison, Alfio V Parisi, Harry J Butler, Nathan J Downs
Tropical Ecuador presents a unique climate in which we study the relationship between the ambient levels of solar ultraviolet radiation and eye disease in the absence of a latitudinal gradient. The national distribution of surface ultraviolet, taking into account MODIS and OMI satellite observation of aerosol, ozone, surface albedo, local elevation and cloud fractions measured during 2011, was compared with the national pterygium (WHO ICD H11) and senile cataract (WHO ICD H25) incidence projected from the 2010 National Institute of Statistics and Census (Ecuador)...
June 21, 2018: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/29916149/arsenic-contamination-subsequent-water-toxicity-and-associated-public-health-risks-in-the-lower-indus-plain-sindh-province-pakistan
#4
Asfandyar Shahab, Shihua Qi, Muhammad Zaheer
Arsenic (As) contamination in drinking water is a global public health risk. The present study highlighted the geological and anthropogenic causes of As contamination in groundwater (GW) and surface water (SW) and assessment of their potential health risks in Sindh province of Pakistan. Upon analyzing 720 GW and SW samples from 18 different sites, the estimates of As in groundwater and surface water was observed in the range of 0 to 125 and 0 to 35 μg/L with mean values of 46.8 and 15.43 μg/L respectively...
June 18, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29915611/plastid-envelope-localized-proteins-exhibit-a-stochastic-spatiotemporal-relationship-to-stromules
#5
Kathleen Delfosse, Michael R Wozny, Kiah A Barton, Neeta Mathur, Nigel Griffiths, Jaideep Mathur
Plastids in the viridiplantae sporadically form thin tubules called stromules that increase the interactive surface between the plastid and the surrounding cytoplasm. Several recent publications that report observations of certain proteins localizing to the extensions have then used the observations to suggest stromule-specific functions. The mechanisms by which specific localizations on these transient and sporadically formed extensions might occur remain unclear. Previous studies have yet to address the spatiotemporal relationship between a particular protein localization pattern and its distribution on an extended stromules and/or the plastid body...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29915508/cryptosporidiosis-a-zoonotic-disease-concern
#6
REVIEW
Natapol Pumipuntu, Supawadee Piratae
Cryptosporidiosis is considered to be a crucial zoonotic disease caused by worldwide distributing parasitic protozoa called Cryptosporidium spp. Cryptosporidiosis becomes a major public health and veterinary concern by affecting in human and various host range species of animals. Essentially, its importance of infection is increasing because of the high incidence in young children, immunocompromised persons, or immunodeficiency syndrome patients, especially in HIV/AIDS, and it is also one of the most causes of mortality in those patients who infected with Cryptosporidium spp...
May 2018: Veterinary World
https://www.readbyqxmd.com/read/29915111/microevolution-of-aquatic-streptococcus-agalactiae-st-261-from-australia-indicates-dissemination-via-imported-tilapia-and-ongoing-adaptation-to-marine-hosts-or-environment
#7
Minami Kawasaki, Jerome Delamare-Deboutteville, Rachel O Bowater, Mark J Walker, Scott Beatson, Nouri L Ben Zakour, Andrew C Barnes
Streptococcus agalactiae (GBS) causes disease in a wide range of animals. The serotype Ib lineage is highly adapted to aquatic hosts, exhibiting substantial genome reduction compared with terrestrial conspecifics. Here we sequence genomes from 40 GBS isolates including 25 from wild fish and captive stingrays in Australia, six local veterinary or human clinical isolates, and nine isolates from farmed tilapia in Honduras and compare with 42 genomes from public databases. Phylogenetic analysis based on non-recombinant core genome SNPs indicated that aquatic serotype Ib isolates from Queensland were distantly related to local veterinary and human clinical isolates...
June 18, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29912194/development-of-an-electrochemical-dna-biosensor-to-detect-a-foodborne-pathogen
#8
Noordiana Nordin, Nor Azah Yusof, Son Radu, Roozbeh Hushiarian
Vibrio parahaemolyticus (V. parahaemolyticus) is a common foodborne pathogen that contributes to a large proportion of public health problems globally, significantly affecting the rate of human mortality and morbidity. Conventional methods for the detection of V. parahaemolyticus such as culture-based methods, immunological assays, and molecular-based methods require complicated sample handling and are time-consuming, tedious, and costly. Recently, biosensors have proven to be a promising and comprehensive detection method with the advantages of fast detection, cost-effectiveness, and practicality...
June 3, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29911725/tailoring-inorganic-nanoadjuvants-towards-next-generation-vaccines
#9
REVIEW
Xia Li, Xiupeng Wang, Atsuo Ito
Vaccines, one of the most effective and powerful public health measures, have saved countless lives over the past century and still have a tremendous global impact. As an indispensable component of modern vaccines, adjuvants play a critical role in strengthening and/or shaping a specific immune response against infectious diseases as well as malignancies. The application of nanotechnology provides the possibility of precisely tailoring the building blocks of nanoadjuvants towards modern vaccines with the desired immune response...
June 18, 2018: Chemical Society Reviews
https://www.readbyqxmd.com/read/29909348/toxicological-risk-assessment-and-prioritization-of-drinking-water-relevant-contaminants-of-emerging-concern
#10
Kirsten A Baken, Rosa M A Sjerps, Merijn Schriks, Annemarie P van Wezel
Toxicological risk assessment of contaminants of emerging concern (CEC) in (sources of) drinking water is required to identify potential health risks and prioritize chemicals for abatement or monitoring. In such assessments, concentrations of chemicals in drinking water or sources are compared to either (i) health-based (statutory) drinking water guideline values, (ii) provisional guideline values based on recent toxicity data in absence of drinking water guidelines, or (iii) generic drinking water target values in absence of toxicity data...
June 13, 2018: Environment International
https://www.readbyqxmd.com/read/29909322/contaminated-landslide-runout-deposits-in-rivers-method-for-estimating-long-term-ecological-risks
#11
G Göransson, J Norrman, M Larson
The potential catastrophic event of a landslide bringing contaminants to surface waters has been highlighted in public media, but there are still few scientific studies analyzing the risk of landslides with contaminated soil. The aim of this study is to present a method to estimate the risk of potential long-term ecological effects on water bodies due to contaminated soil released into a river through a landslide. The study constitutes further development of previous work focusing on the instantaneous (short-term) release of contaminants and associated effects...
June 14, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29906894/testing-constitutive-relations-by-running-and-walking-on-cornstarch-and-water-suspensions
#12
Shomeek Mukhopadhyay, Benjamin Allen, Eric Brown
The ability of a person to run on the surface of a suspension of cornstarch and water has fascinated scientists and the public alike. However, the constitutive relation obtained from traditional steady-state rheology of cornstarch and water suspensions has failed to explain this behavior. In another paper we presented an averaged constitutive relation for impact rheology consisting of an effective compressive modulus of a system-spanning dynamically jammed structure [R. Maharjan et al., this issue, Phys. Rev...
May 2018: Physical Review. E
https://www.readbyqxmd.com/read/29905561/the-impact-of-the-acrylic-monomer-on-the-morphological-structure-of-rat-lingual-mucosa
#13
V Davydenko, I Starchenko, А Davydenko, V Trufanova, V Kuznetsov
The analysis of publications shows that diverse multiple factors can induce changes in taste sensitivity and the main irritants are the chemicals of different types. However, the study of the effect of the components of dental structural materials on the state of lingual mucosa, in particular, taste sensors, has not been fully elucidated to date. The purpose of the paper was the study of the effect of monomer of the "Ftoraks" base acrylic resin on the state of the rats' lingual mucosa within 2-4 weeks after its impact...
May 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29905056/-research-progress-of-porous-tantalum-in-bone-tissue-engineering
#14
REVIEW
Xiaoquan Ding, Xingwang Liu, Jun Chen, Shiyi Chen
Objective : To review the basical research progress of porous tantalum in bone tissue engineering. Methods: The related basical research in fabrication, cytobiology, and surface modification of porous tantalum was reviewed and analyzed. Results: The outstanding physiochemical properties of porous tantalum granted its excellent performance in biocompatibility and osteointegration, as well as promoting cartilage and tendon tissue restoration...
June 1, 2018: Chinese Journal of Reparative and Reconstructive Surgery
https://www.readbyqxmd.com/read/29904658/experimental-data-on-convective-drying-of-potato-samples-with-different-thickness
#15
I Boutelba, S Zid, P Glouannec, A Magueresse, S Youcef-Ali
A laboratory setup is developed to examine the characteristics of convective drying of a moist potato sample. The thickness effect (5, 10 and 15 mm) of product on heat and mass transfer during potato drying was presented. Potato samples were dried at temperature of 51 °C and air velocity of 1 m s-1 . Structural Change (length, width and thickness) of the samples were measured during drying. The heat distribution at different locations, sides surfaces and heart of the samples, was acquired at a time interval of 30 min for the test period...
June 2018: Data in Brief
https://www.readbyqxmd.com/read/29904387/anti-lipoarabinomannan-specific-salivary-iga-as-prognostic-marker-for-leprosy-reactions-in-patients-and-cellular-immunity-in-contacts
#16
André Alan Nahas, Mayara Ingrid de Sousa Lima, Isabela Maria Bernardes Goulart, Luiz Ricardo Goulart
Leprosy causes the most common peripheral neuropathy of infectious etiology, posing an important public health problem worldwide. Understanding the molecular and immunological mechanisms of nerve damage induced by M. leprae is mandatory to develop tools for early diagnosis and preventive measures. The phenolic glycolipid 1 (PGL-1) and lipoarabinomannan (LAM) antigens are major components of the bacterial surface and are implicated on leprosy immunopathogenesis and neural damage. Although the anti-PGL-1 serum IgM is highly used for operational classification of patients, the anti-LAM salivary IgA (sIgA) has not been investigated as diagnostic or prognostic marker in leprosy...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29900806/water-fluoridation-and-dental-caries-in-u-s-children-and-adolescents
#17
G D Slade, W B Grider, W R Maas, A E Sanders
Fluoridation of America's drinking water was among the great public health achievements of the 20th century. Yet there is a paucity of studies from the past 3 decades investigating its dental health benefits in the U.S. POPULATION: This cross-sectional study sought to evaluate associations between availability of community water fluoridation (CWF) and dental caries experience in the U.S. child and adolescent population. County-level estimates of the percentage of population served by CWF (% CWF) from the Centers for Disease Control and Prevention's Water Fluoridation Reporting System were merged with dental examination data from 10 y of National Health and Nutrition Examination Surveys (1999 to 2004 and 2011 to 2014)...
May 1, 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/29900205/data-set-characterizing-the-systemic-alterations-of-microvascular-reactivity-and-capillary-density-in-patients-presenting-with-infective-endocarditis
#18
Eduardo Tibirica, Amanda Barcelos, Cristiane Lamas
This article represents data associated with a prior publication from our research group, under the title: Evaluation of microvascular endothelial function and capillary density in patients with infective endocarditis using laser speckle contrast imaging and video-capillaroscopy [1]. Patients with definite infective endocarditis, under stable clinical conditions, were prospectively included. The clinical and laboratory features are presented for each of them in raw form. Microvascular reactivity was evaluated using a laser speckle contrast imaging (LSCI) system with a laser wavelength of 785 nm...
June 2018: Data in Brief
https://www.readbyqxmd.com/read/29897834/the-complex-rcs-regulatory-cascade
#19
Erin Wall, Nadim Majdalani, Susan Gottesman
RcsB, a response regulator of the FixJ/NarL family, is at the center of a complex network of regulatory inputs and outputs. Cell surface stress is sensed by an outer membrane lipoprotein, RcsF, which regulates interactions of the inner membrane protein IgaA, lifting negative regulation of a phosphorelay. In vivo evidence supports a pathway in which histidine kinase RcsC transfers phosphate to phosphotransfer protein RcsD, resulting in phosphorylation of RcsB. RcsB acts either alone or in combination with RcsA to positively regulate capsule synthesis and synthesis of small RNA (sRNA) RprA as well as other genes, and to negatively regulate motility...
June 13, 2018: Annual Review of Microbiology
https://www.readbyqxmd.com/read/29895151/hepatitis-b-virus-vaccine-breakthrough-infection-surveillance-of-s-gene-mutants-of-hbv
#20
Y Qin, P Liao
Hepatitis B (HB) is a worldwide public health problem, closely related with liver cirrhosis and hepatocellular carcinoma (HCC). The implementation of universal hepatitis B virus (HBV) vaccination programs has led to significant reduction in incidence of acute and chronic HB, liver cirrhosis and HCC. However, this success is now being threatened by the discovery of HBV vaccine breakthrough infection caused by the S gene mutants of HBV, high maternal viral load and virus-induced immunosuppression. An alteration in the antigenicity and immunogenicity of hepatitis B surface antigen (HBsAg) due to S gene mutations may compromise detection of HBsAg (diagnosis-escape mutants), treatment with hepatitis B-specific immunoglobulin (HBIG), and even cause infections in individuals who are antihepatitis B surface antigen (anti-HBs) antibody-positive after immunization (vaccine-escape mutants)...
2018: Acta Virologica
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