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https://www.readbyqxmd.com/read/27917926/clonal-spread-of-mcr-1-in-pmqr-carrying-st34-salmonella-isolates-from-animals-in-china
#1
Xing-Ping Li, Liang-Xing Fang, Jia-Qi Song, Jing Xia, Wei Huo, Jin-Tao Fang, Xiao-Ping Liao, Ya-Hong Liu, Youjun Feng, Jian Sun
Since initial identification in China, the widespread geographical occurrence of plasmid-mediated colistin resistance gene mcr-1 in Enterobacteriaceae has been of great concern. In this study, a total of 22 Salmonella enterica were resistant to colistin, while only five isolates which belonged to ST34 Salmonella enterica serovar Typhimurium (S. Typhimurium) were mcr-1 positive. Four of them shared nearly identical PFGE type, although they were from different host species and diverse geographical locations. All the mcr-1-positive S...
December 5, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27915108/how-should-we-respond-to-the-emergence-of-plasmid-mediated-colistin-resistance-in-humans-and-animals
#2
REVIEW
Jaffar A Al-Tawfiq, Ramanan Laxminarayan, Marc Mendelson
OBJECTIVE: The widespread use of antibiotics in humans and animals contributes to growing rates of antibiotic resistance. Previously treatable bacterial infections now require the last line of antibiotics or are untreatable. For carbapenem-resistant, Gram-negative bacterial infections the antibiotic of last resort is now often colistin. In this review, we present the evidence for the shifting pattern of colistin resistance and discuss how the international community should respond. METHODS: This is a literature review of colistin resistance...
November 30, 2016: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/27895009/an-incp-plasmid-carrying-the-colistin-resistance-gene-mcr-1-in-klebsiella-pneumoniae-from-hospital-sewage
#3
Feifei Zhao, Yu Feng, Xiaoju Lü, Alan McNally, Zhiyong Zong
A Klebsiella pneumoniae strain of ST313 recovered from hospital sewage was found to carry the plasmid-borne colistin resistance gene mcr-1, which was bracketed by two copies of the insertion sequence ISApl1 on a 57-kb self-transmissible IncP type plasmid of a new IncP-1 clade. The carriage of mcr-1 on a self-transmissible broad-host-range plasmid highlights that mcr-1 has the potential to be spread beyond the Enterobacteriaceae.
November 28, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27894831/improvement-in-routine-detection-of-colistin-resistance-in-e-coli-isolated-in-veterinary-diagnostic-laboratories
#4
Eric Jouy, Marisa Haenni, Laëtitia Le Devendec, Aurélie Le Roux, Pierre Châtre, Jean-Yves Madec, Isabelle Kempf
We have developed a phenotypic method suited to the systematic screening of resistance to colistin in E. coli, including those with the mcr-1 gene, by the absence of an inhibition zone after an application of a single drop of 8mg/L colistin solution on a previously inoculated Mueller-Hinton agar.
November 26, 2016: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/27894674/emergence-of-plasmid-mediated-colistin-resistance-and-new-delhi-metallo-%C3%AE-lactamase-genes-in-extensively-drug-resistant-escherichia-coli-isolated-from-a-patient-in-thailand
#5
Wantana Paveenkittiporn, Anusak Kerdsin, Sukanya Chokngam, Charatdao Bunthi, Somchai Sangkitporn, Christopher J Gregory
We reported a case of Escherichia coli with colistin resistance and an extensively drug-resistant phenotype. Molecular analysis revealed that the isolate carried mcr-1 and multiple β-lactamase genes includingblaNDM1, blaCTX-M-15, blaTEM1, and blaCMY-2. This is the first report of a clinical mcr-1 isolate in Thailand highlighting the urgent need for a comprehensive antimicrobial resistance containment strategy to prevent further spread.
November 14, 2016: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/27893854/dissemination-and-mechanism-for-the-mcr-1-colistin-resistance
#6
Rongsui Gao, Yongfei Hu, Zhencui Li, Jian Sun, Qingjing Wang, Jingxia Lin, Huiyan Ye, Fei Liu, Swaminath Srinivas, Defeng Li, Baoli Zhu, Ya-Hong Liu, Guo-Bao Tian, Youjun Feng
Polymyxins are the last line of defense against lethal infections caused by multidrug resistant Gram-negative pathogens. Very recently, the use of polymyxins has been greatly challenged by the emergence of the plasmid-borne mobile colistin resistance gene (mcr-1). However, the mechanistic aspects of the MCR-1 colistin resistance are still poorly understood. Here we report the comparative genomics of two new mcr-1-harbouring plasmids isolated from the human gut microbiota, highlighting the diversity in plasmid transfer of the mcr-1 gene...
November 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27891118/colistin-in-pig-production-chemistry-mechanism-of-antibacterial-action-microbial-resistance-emergence-and-one-health-perspectives
#7
REVIEW
Mohamed Rhouma, Francis Beaudry, William Thériault, Ann Letellier
Colistin (Polymyxin E) is one of the few cationic antimicrobial peptides commercialized in both human and veterinary medicine. For several years now, colistin has been considered the last line of defense against infections caused by multidrug-resistant Gram-negative such as Acinetobacter baumannii, Pseudomonas aeruginosa, and Klebsiella pneumoniae. Colistin has been extensively used orally since the 1960s in food animals and particularly in swine for the control of Enterobacteriaceae infections. However, with the recent discovery of plasmid-mediated colistin resistance encoded by the mcr-1 gene and the higher prevalence of samples harboring this gene in animal isolates compared to other origins, livestock has been singled out as the principal reservoir for colistin resistance amplification and spread...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27872110/correction-for-leangapichart-et-al-acquisition-of-mcr-1-plasmid-mediated-colistin-resistance-in-escherichia-coli-and-klebsiella-pneumoniae-during-hajj-2013-and-2014
#8
Thongpan Leangapichart, Philippe Gautret, Philippe Brouqui, Ziad A Memish, Didier Raoult, Jean-Marc Rolain
No abstract text is available yet for this article.
December 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27865627/epidemiology-of-infections-caused-by-polymyxin-resistant-pathogens
#9
Helen Giamarellou
Confronting the storm of carbapenemase-producing Gram-negative pathogens and thus facing the threat of untreatable infections, the medical community revived colistin. Not long since its re-introduction and despite the fact that resistance to colistin at least in Escherichia coli is rare, chromosomally-mediated colistin resistance in metallo-β-lactamase-producing Klebsiella pneumoniae strains was reported in 2004 from Greece. Subsequent studies revealed the highest predominance in Italy (38%) and Greece (26%), with colistin-resistant (Col-R) strains frequently carrying a carbapenemase...
November 10, 2016: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/27855074/emergence-of-colistin-resistance-gene-mcr-1-in-cronobacter-sakazakii-producing-ndm-9-and-escherichia-coli-from-the-same-animal
#10
Bao-Tao Liu, Feng-Jing Song, Ming Zou, Zhi-Hui Hao, Hu Shan
We report the presence of mcr-1 in E. coli and carbapenem-resistant Cronobacter sakazakii, from the same diseased chicken. The mcr-1gene linked with ISApl1 was located on two different IncI2 plasmids including one multidrug plasmid in E. coli, whereas blaNDM-9-fosA3 was on a IncB/O plasmid in C. sakazakii The development of fosA3-blaNDM-9 resistance region was mediated by IS26 The co-location of mcr-1 or blaNDM-9with other resistance genes will accelerate the dissemination of the two genes.
November 14, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27855068/prevalence-of-colistin-resistance-gene-mcr-1-and-absence-of-mcr-2-in-escherichia-coli-isolated-from-healthy-food-producing-animals-in-japan
#11
Michiko Kawanishi, Hitoshi Abo, Manao Ozawa, Mariko Uchiyama, Takahiro Shirakawa, Satowa Suzuki, Ayaka Shima, Akifumi Yamashita, Tsuyoshi Sekizuka, Kengo Kato, Makoto Kuroda, Ryoji Koike, Mayumi Kijima
We screened mcr-1 and mcr-2 genes in 9,306 Escherichia coli strains isolated from healthy animals in the Japanese Veterinary Antimicrobial Resistance Monitoring system (JVARM). mcr-1 was detected in 39 strains (5, 20, and 14 isolated from cattle, swine and broiler, respectively), whereas mcr-2 was not detected. mcr-2 was also not detected with the investigation sequence homology search against our curated GenEpid-J database.
November 14, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27855065/prevalence-of-mcr-1-in-us-food-animal-cecal-contents
#12
Richard J Meinersmann, Scott R Ladely, Jodie R Plumblee, Kimberly L Cook, Eileen Thacker
A survey of 2003 cecal content samples from chickens, turkeys, cattle and swine at slaughter facilities in the United States was conducted to estimate the prevalence of mcr-1 gene conferring resistance to colistin in Enterobacteriaceae Two cecal samples from swine had Escherichia coli with IncI2 plasmids bearing the mcr-1 gene.
November 14, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27836380/colistin-use-and-colistin-resistance-in-bacteria-from-animals
#13
Isabelle Kempf, Eric Jouy, Claire Chauvin
Colistin has been used in veterinary medicine for decades, mainly for the prevention and treatment of Enterobacteriaceae infections. However, data regarding colistin resistance in bacteria from animals and food of animal origin are relatively scarce, partly because there are methodological difficulties hampering the analysis of susceptibility to colistin. Most data regarding clinical isolates are related to enteropathogenic Escherichia coli and Salmonella. The resistance percentages are sometimes high for pathogenic strains, and the mcr-1 gene has been detected in pathogenic E...
October 27, 2016: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/27834721/complete-genome-sequence-of-a-colistin-resistance-gene-mcr-1-bearing-isolate-of-escherichia-coli-from-the-united-states
#14
Richard J Meinersmann, Scott R Ladely, James L Bono, Jodie R Plumblee, M Carolina Hall, Linda L Genzlinger, Kimberly L Cook
Transmissible colistin resistance conferred by the mcr-1 gene-bearing IncI2 plasmid has been recently reported in Escherichia coli in the United States. We report here the completed genome sequence of a second E. coli strain isolated from swine in the United States that carried the mcr-1 gene on an IncI2-type plasmid.
November 10, 2016: Genome Announcements
https://www.readbyqxmd.com/read/27821458/co-production-of-mcr-1-and-ndm-1-by-colistin-resistant-escherichia-coli-isolated-from-a-healthy-individual
#15
Lan-Lan Zhong, Yan-Fen Zhang, Yohei Doi, Xi Huang, Xue-Fei Zhang, Kun-Jiao Zeng, Cong Shen, Sandip Patil, Yong Xing, Yutian Zou, Guo-Bao Tian
mcr-1, the first transferable plasmid-mediated colistin resistance gene, was reported in Escherichia coli isolates from food animals, food and patients in China and now has been reported worldwide (1).….
November 7, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27795381/description-of-the-first-escherichia-coli-clinical-isolate-harboring-colistin-resistance-mcr-1-gene-from-the-indian-subcontinent
#16
Mashkoor Mohsin, Shahbaz Raza, Nicole Roschanski, Sebastian Guenther, Aamir Ali, Peter Schierack
The first report of plasmid-mediated colistin resistance among Enterobacteriaceae in China sounded alarms in the medical community worldwide (1).….
October 24, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27769683/-low-prevalence-of-mcr-1-positive-enterobacteriaceae-isolates-in-a-health-area
#17
Víctor José Heras-Cañas, Lorena López-Cerero, Paula Díaz de-Alba, Álvaro Pascual
No abstract text is available yet for this article.
October 18, 2016: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/27747206/current-state-of-resistance-to-antibiotics-of-last-resort-in-south-africa-a-review-from-a-public-health-perspective
#18
John Osei Sekyere
A review of the literature was undertaken to delineate the current level and mechanisms of resistance to carbapenems, colistin, and tigecycline in South Africa. Thirty-two English publications and 32 National Institute of Communicable Diseases communiqués identified between early January 2000 and 20 May, 2016 showed substantial reports of NDM (n = 860), OXA-48 (n = 584), VIM (n = 131), and IMP (n = 45) carbapenemases within this period, mainly in Klebsiella pneumoniae (n = 1138), Acinetobacter baumannii (n = 332), Enterobacter cloacae (n = 201), and Serratia marcescens (n = 108)...
2016: Frontiers in Public Health
https://www.readbyqxmd.com/read/27741523/complex-dissemination-of-the-diversified-mcr-1-harbouring-plasmids-in-escherichia-coli-of-different-sequence-types
#19
Qingjing Wang, Zhencui Li, Jingxia Lin, Xiuna Wang, Xianbo Deng, Youjun Feng
The emergence of the mobilized colistin resistance gene, representing a novel mechanism for bacterial drug resistance, challenges the last resort against the severe infections by Gram-negative bacteria with multi-drug resistances. Very recently, we showed the diversity in the mcr-1-carrying plasmid reservoirs from the gut microbiota. Here, we reported that a similar but more complex scenario is present in the healthy swine populations, Southern China, 2016. Amongst the 1026 pieces of Escherichia coli isolates from 3 different pig farms, 302 E...
October 12, 2016: Oncotarget
https://www.readbyqxmd.com/read/27697756/occurrence-of-mcr-1-in-colistin-resistant-salmonella-enterica-isolates-recovered-from-humans-and-animals-in-italy-2012-to-2015
#20
LETTER
Chiara Carnevali, Marina Morganti, Erika Scaltriti, Luca Bolzoni, Stefano Pongolini, Gabriele Casadei
No abstract text is available yet for this article.
December 2016: Antimicrobial Agents and Chemotherapy
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