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Víctor José Heras-Cañas, Lorena López-Cerero, Paula Díaz de-Alba, Álvaro Pascual
No abstract text is available yet for this article.
October 18, 2016: Enfermedades Infecciosas y Microbiología Clínica
John Osei Sekyere
A review of the literature was undertaken to delineate the current level and mechanisms of resistance to carbapenems, colistin, and tigecycline in South Africa. Thirty-two English publications and 32 National Institute of Communicable Diseases communiqués identified between early January 2000 and 20 May, 2016 showed substantial reports of NDM (n = 860), OXA-48 (n = 584), VIM (n = 131), and IMP (n = 45) carbapenemases within this period, mainly in Klebsiella pneumoniae (n = 1138), Acinetobacter baumannii (n = 332), Enterobacter cloacae (n = 201), and Serratia marcescens (n = 108)...
2016: Frontiers in Public Health
Qingjing Wang, Zhencui Li, Jingxia Lin, Xiuna Wang, Xianbo Deng, Youjun Feng
The emergence of the mobilized colistin resistance gene, representing a novel mechanism for bacterial drug resistance, challenges the last resort against the severe infections by Gram-negative bacteria with multi-drug resistances. Very recently, we showed the diversity in the mcr-1-carrying plasmid reservoirs from the gut microbiota. Here, we reported that a similar but more complex scenario is present in the healthy swine populations, Southern China, 2016. Amongst the 1026 pieces of Escherichia coli isolates from 3 different pig farms, 302 E...
October 12, 2016: Oncotarget
Chiara Carnevali, Marina Morganti, Erika Scaltriti, Luca Bolzoni, Stefano Pongolini, Gabriele Casadei
The first case of plasmid-mediated resistance to colistin due to the gene mcr-1 was reported in China in late 2015 (1).….
October 3, 2016: Antimicrobial Agents and Chemotherapy
Lívia Viganor, Orla Howe, Pauraic McCarron, Malachy McCann, Michael Devereux
The "antibiotic era", characterized by the overuse and misuse of antibiotics, over the last half-century has culminated in the present critical "era of resistance". The treatment of bacterial infections is challenging because of a decline in the current arsenal of useful antibiotics and the slow rate of new drug development. The discovery of a new gene (mcr-1) in 2015, which enables bacteria to be highly resistant to polymyxins (such as colistin), the last line of antibiotic defence left, heralds a new level of concern as this gene is susceptible to horizontal gene transfer, with alarming potential to be spread between different bacterial populations, suggesting that the progression from "extensive drug resistance" to "pan-drug resistance" may be inevitable...
October 3, 2016: Current Topics in Medicinal Chemistry
(no author information available yet)
In the report, "Investigation of Escherichia coli Harboring the mcr-1 Resistance Gene - Connecticut, 2016," the Acknowledgments should have included the following: Alycia McNutt, David Santoro, Christina Nishimura, Diane Noel, Katherine A. Kelley Public Health Laboratory, Connecticut Department of Public Health.
2016: MMWR. Morbidity and Mortality Weekly Report
Jocelyn Qi Min Teo, Yiying Cai, Tze-Peng Lim, Thuan Tong Tan, Andrea Lay-Hoon Kwa
Singapore is an international travel and medical hub and faces a genuine threat for import and dissemination of bacteria with broad-spectrum resistance. In this review, we described the current landscape and management of carbapenem resistance in Gram-negative bacteria (GNB) in Singapore. Notably, the number of carbapenem-resistant Enterobacteriaceae has exponentially increased in the past two years. Resistance is largely mediated by a variety of mechanisms. Polymyxin resistance has also emerged. Interestingly, two Escherichia coli isolates with plasmid-mediated mcr-1 genes have been detected...
February 16, 2016: Microorganisms
Daniela Jones-Dias, Vera Manageiro, Eugénia Ferreira, Paula Barreiro, Luís Vieira, Inês B Moura, Manuela Caniça
The spread of antibiotic resistant bacteria throughout the food chain constitutes a public health concern. To understand the contribution of fresh produce in shaping antibiotic resistance bacteria and integron prevalence in the food chain, 333 antibiotic resistance Gram negative isolates were collected from organic and conventionally produced fruits (pears, apples, and strawberries) and vegetables (lettuces, tomatoes, and carrots). Although low levels of resistance have been detected, the bacterial genera identified in the assessed fresh produce are often described not only as environmental, but mostly as commensals and opportunistic pathogens...
2016: Frontiers in Microbiology
Feifei Zhao, Zhiyong Zong
The newly-identified plasmid-borne colistin resistance gene mcr-1 was found in a Kluyvera ascorbata from hospital sewage in China. mcr-1 was carried by a 57-kb self-transmissible IncI2 plasmid. Unlike the previous report, mcr-1 was not associated with ISApl1 and was inserted into a gene encoding a putative membrane protein due to an unknown mechanism. This study highlights that mcr-1 has spread to multiple bacterial species.
September 26, 2016: Antimicrobial Agents and Chemotherapy
Jian Sun, Run-Shi Yang, Qijing Zhang, Youjun Feng, Liang-Xing Fang, Jing Xia, Liang Li, Xiao-Yue Lv, Jia-Hong Duan, Xiao-Ping Liao, Ya-Hong Liu
Carbapenem and colistin are the last-resort antibiotics used for treating multidrug-resistant Gram-negative pathogens. Here, we report, for the first time, co-transfer of resistance to both classes of antibiotics by a mobile IncX3-X4 hybrid plasmid in an Escherichia coli isolate. Spread of such a plasmid is of great concern for clinical therapy, and heightened efforts are needed to control its dissemination.
2016: Nature Microbiology
Amber M Vasquez, Noelisa Montero, Mark Laughlin, Ehren Dancy, Russell Melmed, Lynn Sosa, Louise Francois Watkins, Jason P Folster, Nancy Strockbine, Heather Moulton-Meissner, Uzma Ansari, Matthew L Cartter, Maroya Spalding Walters
The mcr-1 gene confers resistance to the polymyxins, including the antibiotic colistin, a medication of last resort for multidrug-resistant infections. The mcr-1 gene was first reported in 2015 in food, animal, and patient isolates from China (1) and is notable for being the first plasmid-mediated colistin resistance mechanism to be identified. Plasmids can be transferred between bacteria, potentially spreading the resistance gene to other bacterial species. Since its discovery, the mcr-1 gene has been reported from Africa, Asia, Europe, South America, and North America (2,3), including the United States, where it has been identified in Escherichia coli isolated from three patients and from two intestinal samples from pigs (2,4-6)...
2016: MMWR. Morbidity and Mortality Weekly Report
Kelly E Kline, Jordan Shover, Alexander J Kallen, David R Lonsway, Sharon Watkins, Jeffrey R Miller
In 2015, scientists reported the emergence of the plasmid-encoded mcr-1 gene conferring bacterial resistance to the antibiotic colistin (1), signaling potential emergence of a pandrug-resistant bacterium. In May 2016, mcr-1-positive Escherichia coli was first isolated from a specimen from a U.S. patient (2) when a Pennsylvania woman was evaluated for a urinary tract infection. The urine culture and subsequent testing identified the gene in an extended-spectrum beta-lactamase (ESBL)-producing E. coli with reduced susceptibility to colistin...
2016: MMWR. Morbidity and Mortality Weekly Report
C O'Connor, M Cormican, T W Boo, E McGrath, B Slevin, A O'Gorman, M Commane, S Mahony, E O'Donovan, J Powell, R Monahan, C Finnegan, M G Kiernan, J C Coffey, L Power, N H O'Connell, C P Dunne
BACKGROUND: Carbapenemase-producing Enterobacteriaceae (CPE) may cause healthcare-associated infections with high mortality rates. New Delhi metallo-β-lactamase-1 (NDM-1) is among the most recently discovered carbapenemases. AIM: To report the first outbreak of NDM-1 CPE in Ireland, including microbiological and epidemiological characteristics, and assessing the impact of infection prevention and control measures. METHODS: This was a retrospective microbiological and epidemiological review...
August 19, 2016: Journal of Hospital Infection
Thongpan Leangapichart, Philippe Gautret, Philippe Brouqui, Ziad Mimish, Didier Raoult, Jean-Marc Rolain
A plasmid-mediated transferable colistin resistance gene, mcr-1, was recently described in China (1) and was rapidly reported in several other countries (2).….
September 12, 2016: Antimicrobial Agents and Chemotherapy
Erik Snesrud, Susu He, Michael Chandler, John P Dekker, Alison B Hickman, Patrick McGann, Fred Dyda
Analysis of mcr-1-containing sequences identified a common ∼2,607bp DNA segment that in many cases is flanked on one or both ends by ISApl1 We present evidence that mcr-1 is mobilized by an ISApl1 composite transposon, which has, in some cases, subsequently lost one or both copies of ISApl1 We also show that in some circumstances mcr-1 can be mobilized by a single, upstream copy of ISApl1 in conjunction with the remnants of a downstream ISApl1.
September 12, 2016: Antimicrobial Agents and Chemotherapy
Farid El Garch, Marlène Sauget, Didier Hocquet, David Lechaudee, Frédérique Woehrle, Xavier Bertrand
OBJECTIVES: In November 2015, a plasmid-mediated colistin resistance, MCR-1, was described in animals, food and humans in China and it was considered as a potential emerging threat to public health. Therefore, we screened for mcr-1 gene a European collection of colistin resistant E. coli (n=218) and Salmonella spp (n=74) isolated from diseased food-producing animals between 2004 and 2014 and characterized the mcr-1-positive clones. METHODS: Screening for mcr-1 gene was performed by PCR on isolates for which inhibition diameter was < 15 mm around a 50-μg disk of colistin...
September 8, 2016: Clinical Microbiology and Infection
Richard J Meinersmann, Scott R Ladely, Jodie R Plumblee, M Carolina Hall, Sheron A Simpson, Linda L Ballard, Brian E Scheffler, Linda L Genzlinger, Kimberly L Cook
Transmissible colistin resistance in the form of an mcr-1-gene-bearing plasmid has been recently reported in Enterobacteriaceae in several parts of the world. We report here the completed genome sequence of an Escherichia coli strain isolated from swine in the United States that carried the mcr-1 gene on an IncI2-type plasmid.
2016: Genome Announcements
Christa Ewers, Stephan Göttig, Maria Bülte, Sophie Fiedler, Manuela Tietgen, Ursula Leidner, Carsten Heydel, Rolf Bauerfeind, Torsten Semmler
Sequence type 131 (ST131) is one of the predominant Escherichia coli lineages among extraintestinal pathogenic E. coli (ExPEC) that causes a variety of diseases in humans and animals and frequently shows multidrug resistance. Here, we report the first genome sequence of an ST131-ExPEC strain from poultry carrying the plasmid-encoded colistin resistance gene mcr-1.
2016: Genome Announcements
D Ortega-Paredes, P Barba, J Zurita
Colistin resistance mediated by the mcr-1 gene has been reported worldwide, but to date not from the Andean region, South America. We report the first clinical isolate of Escherichia coli harbouring the mcr-1 gene in Ecuador. The strain was isolated from peritoneal fluid from a 14-year-old male with acute appendicitis, and subjected to molecular analysis. The minimum inhibitory concentration of colistin for the strain was 8 mg/ml and it was susceptible to carbapenems but resistant to tigecycline. The strain harboured mcr-1 and bla CTX-M-55 genes and was of sequence type 609...
October 2016: Epidemiology and Infection
José R Mediavilla, Amee Patrawalla, Liang Chen, Kalyan D Chavda, Barun Mathema, Christopher Vinnard, Lisa L Dever, Barry N Kreiswirth
UNLABELLED: Colistin is increasingly used as an antibiotic of last resort for the treatment of carbapenem-resistant Gram-negative infections. The plasmid-borne colistin resistance gene mcr-1 was initially identified in animal and clinical samples from China and subsequently reported worldwide, including in the United States. Of particular concern is the spread of mcr-1 into carbapenem-resistant bacteria, thereby creating strains that approach pan-resistance. While several reports of mcr-1 have involved carbapenem-resistant strains, no such isolates have been described in the United States...
2016: MBio
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