keyword
MENU ▼
Read by QxMD icon Read
search

mcr-1

keyword
https://www.readbyqxmd.com/read/28730149/review-of-antibiotic-resistance-in-the-indian-ocean-commission-a-human-and-animal-health-issue
#1
REVIEW
Noellie Gay, Olivier Belmonte, Jean-Marc Collard, Mohamed Halifa, Mohammad Iqbal Issack, Saindou Mindjae, Philippe Palmyre, Abdul Aziz Ibrahim, Harena Rasamoelina, Loïc Flachet, Laurent Filleul, Eric Cardinale
Antimicrobial resistance (AMR) is a major threat to human, animal health, and environment worldwide. For human, transmission occurred through a variety of routes both in health-care settings and community. In animals, AMR was reported in livestock, pets, and wildlife; transmission of AMR can be zoonotic with the probably most important route being foodborne transmission. The Indian Ocean Commission (IOC), composed of Comoros, Madagascar, Mauritius, Reunion (France), and Seychelles recognized the surveillance of AMR in both animal and human as a main public health priority for the region...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28726622/mcr-1-and-blakpc-3-in-escherichia-coli-sequence-type-744-after-meropenem-and-colistin-therapy-portugal
#2
Marta Tacão, Rafael Dos Santos Tavares, Pedro Teixeira, Inês Roxo, Elmano Ramalheira, Sónia Ferreira, Isabel Henriques
Escherichia coli Ec36 was recovered from a patient in Portugal after treatment with meropenem and colistin. Besides an IncF plasmid with Tn1441d-blaKPC-3, already reported in clinical strains in this country, E. coli Ec36 co-harbored an IncX4::mcr-1 gene. Results highlight emerging co-resistance to carbapenems and polymyxins after therapy with drugs from both classes.
August 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28724555/susceptibility-testing-for-the-polymyxins-two-steps-back-three-steps-forward
#3
Shawn Vasoo
Optimizing and standardizing susceptibility testing for the polymyxins have become a pressing issue given the rise multidrug-resistant Gram-negative bacilli. Recently both CLSI-EUCAST have recommended broth microdilution (BMD) (without polysorbate) as the reference method for polymyxin susceptibility testing. In this issue, Chew et al. (doi: https://doi.org/10.1128JCM.00268-17.) compare the performance of three commercial BMD panels and the Etest to reference BMD for polymyxin B and colistin, on 76 Enterobacteriaceae isolates (21 mcr-1 positive)...
July 19, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28721352/detection-of-mcr-1-carrying-escherichia-coli-causing-bloodstream-infection-in-a-new-york-city-hospital-avian-origins-human-concerns
#4
Nenad Macesic, Daniel Green, Zheng Wang, Sean B Sullivan, Kevin Shim, Sarah Park, Susan Whittier, E Yoko Furuya, Angela Gomez-Simmonds, Anne-Catrin Uhlemann
The spread of mcr-1 in the United States remains poorly defined. mcr-1-producing Escherichia coli that also carried blaSHV-12 was detected in a hospitalized patient. No additional cases were identified during screening of 801 Gram-negative isolates. Genomic sequencing identified an IncX4 mcr-1- harboring plasmid and ST117 clonal background associated with avian pathogenic E coli.
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28705756/emergence-of-colistin-resistant-escherichia-coli-clinical-isolates-harboring-mcr-1-in-vietnam
#5
Tatsuya Tada, Pham Hong Nhung, Kayo Shimada, Mitsuhiro Tsuchiya, Doan Mai Phuong, Nguyen Quoc Anh, Norio Ohmagari, Teruo Kirikae
The mcr-1 was first detected on a plasmid in colistin-resistant Escherichia coli from livestock and patients in China. We described here the emergence of colistin-resistant E. coli clinical isolates harboring mcr-1 on the chromosomes in Vietnam. To our knowledge, this is the first report of hospital-acquired E. coli isolates harboring mcr-1 in a medical setting in Vietnam.
July 10, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28698568/an-allelic-variant-of-the-pmrb-sensor-kinase-responsible-for-colistin-resistance-in-an-escherichia-coli-strain-of-clinical-origin
#6
Antonio Cannatelli, Tommaso Giani, Noemi Aiezza, Vincenzo Di Pilato, Luigi Principe, Francesco Luzzaro, Cesira L Galeotti, Gian Maria Rossolini
We investigated the colistin resistance mechanism in an Escherichia coli strain (LC711/14) isolated in Italy in 2014, from an urinary tract infection, which was previously shown to express a colistin resistance mechanism different from mcr-1. LC711/14 was found to carry a novel mutation in the pmrB gene, resulting in a leucine to proline amino acid substitution at position 10 of the PmrB sensor kinase component of the PmrAB signal transduction system. The role of this substitution in colistin resistance was documented by expression of the wild-type and mutated alleles in a pmrB deletion derivative of the E...
July 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28689922/detection-of-the-colistin-resistance-gene-mcr-1-in-pathogenic-escherichia-coli-from-pigs-affected-by-post-weaning-diarrhoea-in-italy
#7
Ludovica Curcio, Andrea Luppi, Paolo Bonilauri, Yuri Gherpelli, Giovanni Pezzotti, Michele Pesciaroli, Chiara Francesca Magistrali
OBJECTIVES: The aim of this study was to investigate the presence of plasmid-mediated colistin resistance genes in Escherichia coli from pigs affected by post-weaning diarrhoea (PWD). METHODS: DNA samples collected from 51 E. coli isolates from Italian pigs affected by PWD in 2015-2016 were studied. Isolates were classified as presumptively resistant to colistin by routine susceptibility testing and were investigated for the presence of the mcr-1 gene of plasmid origin by PCR...
July 6, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28683827/expanding-landscapes-of-the-diversified-mcr-1-bearing-plasmid-reservoirs
#8
Qingjing Wang, Jian Sun, Jun Li, Youfa Ding, Xing-Ping Li, Jingxia Lin, Bachar Hassan, Youjun Feng
BACKGROUND: Polymyxin is a cationic polypeptide antibiotic that can disrupt bacterial cell membrane by interacting with its lipopolysaccharide molecules and is used as a last resort drug against lethal infections by the carbapenem-resistant superbugs (like NDM-1). However, global discovery of the MCR-1 colistin resistance dramatically challenges the newly renewed interest in colistin for clinical use. METHODS: The mcr-1-harboring plasmids were acquired from swine and human Escherichia coli isolated in China, from 2015 to 2016, and subjected to Illumina PacBio RSII and Hi-Seq2000 for full genome sequencing...
July 6, 2017: Microbiome
https://www.readbyqxmd.com/read/28678874/molecular-characteristics-of-mcr-1-carrying-plasmids-and-new-mcr-1-variant-recovered-from-polyclonal-clinical-escherichia-coli-from-argentina-and-canada
#9
Nathalie Tijet, Diego Faccone, Melina Rapoport, Christine Seah, Fernando Pasterán, Paola Ceriana, Ezequiel Albornoz, Alejandra Corso, Alejandro Petroni, Roberto G Melano
We have characterized nine mcr-1-harboring plasmids from clinical Escherichia coli isolates previously described in Argentina and Canada. Three of these plasmids carried a mcr-1-variant called here mcr-1.5. All these E. coli isolates were not clonally related and were recovered in different years and locations. However, their mcr-1-harboring plasmids showed high identity among them and to others characterized in other countries, which strongly suggests that this plasmid-type is playing an important role in spreading this mechanism of resistance to polymyxins...
2017: PloS One
https://www.readbyqxmd.com/read/28674313/first-detection-of-escherichia-coli-harboring-mcr-1-gene-from-retail-domestic-chicken-meat-in-japan
#10
Yusuke Ohsaki, Wataru Hayashi, Satomi Saito, Shunsuke Osaka, Yui Taniguchi, Shota Koide, Kumiko Kawamura, Yukiko Nagano, Yoshichika Arakawa, Noriyuki Nagano
Global spread of plasmid-mediated colistin resistance gene, mcr-1 poses a public health concern because colistin is the last-line-of-defense against severe infections due to multidrug-resistant Gram- negative bacteria. In Japan, a few studies have reported the prevalence of mcr-1 among food animal-derived Escherichia coli isolates, but the epidemiology of mcr-1 from retail meats is not well known. We report here the first detection of mcr-1 from retail chicken meats. A total of 70 ESBL-producing E. coli isolates recovered from retail chicken meats collected between August 2015 and June 2016 were screened for mcr-1, which resulted in positive for one isolate of CTX-M-1 producing E...
July 1, 2017: Japanese Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28671537/the-distribution-of-carbapenem-and-colistin-resistance-in-gram-negative-bacteria-from-the-tamil-nadu-region-in-india
#11
Prasanth Manohar, Thamaraiselvan Shanthini, Ramankannan Ayyanar, Bulent Bozdogan, Aruni Wilson, Ashok J Tamhankar, Ramesh Nachimuthu, Bruno S Lopes
PURPOSE: The occurrence of carbapenem- and colistin-resistance among Gram-negative bacteria is increasing worldwide. The aim of this study was to understand the distribution of carbapenem- and colistin-resistance in two areas in Tamil Nadu, India. METHODOLOGY: The clinical isolates (n=89) used in this study were collected from two diagnostic centres in Tamil Nadu, India. The bacterial isolates were screened for meropenem- and colistin-resistance. Further, resistance genes blaNDM-1, blaOXA-48-like, blaIMP, blaVIM, blaKPC, mcr-1 and mcr-2 and integrons were studied...
July 3, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28668693/molecular-epidemiology-of-colistin-resistant-enterobacteriaceae-in-inpatients-and-avian-from-china-high-prevalence-of-mcr-negative-klebsiella-pneumoniae
#12
Xiaojuan Wang, Yuqing Liu, Xiaomei Qi, Ruobing Wang, Longyang Jin, Min Zhao, Yawei Zhang, Qi Wang, Hongbin Chen, Hui Wang
Whether chromosomal and transmissible mechanisms contribute simultaneously to colistin resistance in Klebsiella pneumoniae and Escherichia coli remains unknown. This study aims to identify the underlying mechanisms of colistin-resistance in inpatient and avian K. pneumoniae and E. coli in China. We retrospectively screened 2353 Enterobacteriaceae isolates from inpatients at multi-centers during 2011-2014, and 168 avian isolates from one slaughterhouse in 2013 for the presence of MCR-1/MCR-2. Mutations and transcriptional levels of the chromosomal RamA, PhoPQ, and PmrAB genes were determined by PCR and RT-qPCR...
June 28, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28668691/colistin-resistance-gene-mcr-1-in-children-s-gut-flora
#13
Yan-Yan Hu, Yue-Ling Wang, Qiao-Ling Sun, Zi-Xian Huang, Han-Yu Wang, Rong Zhang, Gong-Xiang Chen
The aim of this study was to clarify the prevalence and transmission mechanism(s) of mcr-1 in children's gut flora. Fecal samples (n=173) were obtained from non-diarrhea patients at the Children's Hospital of Zhejiang University. Polymerase chain reaction-based analysis indicated that 17 isolates from 9.8% of the samples were positive for mcr-1; these comprised 16 E. coli isolates and one C. freundii. Nine mcr-1-bearing isolates co-expressed extended-spectrum beta-lactamase genes but plasmid-mediated quinolone resistance genes were not detected...
June 28, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28668687/lack-of-experimental-evidence-to-support-mcr-1-positive-escherichia-coli-strain-selection-during-oral-administration-of-colistin-at-recommended-and-higher-dose-given-by-gavage-in-weaned-piglets
#14
Alexis Viel, Jérôme Henri, Agnès Perrin-Guyomard, Julian Laroche, William Couet, Nicolas Grégoire, Michel Laurentie
In this study, we assessed the selective effect of colistin orally administered to healthy weaned piglets harbouring an intestinal mcr-1-positive Escherichia coli strain. Maximum recommended dose and a higher dose often used in European pig farms were given by gavage. No selection of the mcr-1-positive strain was observed in our controlled conditions whatever the dose. Further investigations in real farming conditions seem necessary.
June 28, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28666753/first-report-of-an-e-coli-strain-from-swine-carrying-an-oxa-181-carbapenemase-and-colistin-resistance-determinant-mcr-1
#15
Sandra Pulss, Torsten Semmler, Ellen Prenger-Berninghoff, Rolf Bauerfeind, Christa Ewers
Plasmid-mediated resistance in Enterobacteriaceae against carbapenems and colistin represents an emerging threat for public health. Although animals have been identified as a relevant source of multidrug-resistant (MDR) bacteria, there are only few reports about the presence of carbapenemases in animal isolates. Using Mueller-Hinton agar with meropenem, 7,850 fecal E. coli isolates obtained from 2,160 pigs were screened for carbapenem non-susceptibility. Eleven isolates showed growth on meropenem agar but only two proved positive for a carbapenemase gene, namely blaOXA-48-like, by PCR...
June 27, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28655818/novel-plasmid-mediated-colistin-resistance-gene-mcr-3-in-escherichia-coli
#16
Wenjuan Yin, Hui Li, Yingbo Shen, Zhihai Liu, Shaolin Wang, Zhangqi Shen, Rong Zhang, Timothy R Walsh, Jianzhong Shen, Yang Wang
The mobile colistin resistance gene mcr-1 has attracted global attention, as it heralds the breach of polymyxins, one of the last-resort antibiotics for the treatment of severe clinical infections caused by multidrug-resistant Gram-negative bacteria. To date, six slightly different variants of mcr-1, and a second mobile colistin resistance gene, mcr-2, have been reported or annotated in the GenBank database. Here, we characterized a third mobile colistin resistance gene, mcr-3 The gene coexisted with 18 additional resistance determinants in the 261-kb IncHI2-type plasmid pWJ1 from porcine Escherichia colimcr-3 showed 45...
June 27, 2017: MBio
https://www.readbyqxmd.com/read/28652197/emergence-of-drug-resistant-bacteria-at-the-hajj-a-systematic-review
#17
REVIEW
Thongpan Leangapichart, Jean-Marc Rolain, Ziad A Memish, Jaffar A Al-Tawfiq, Philippe Gautret
BACKGROUND: Hajj is the annual mass gathering of Muslims, and is a reservoir and potential source of bacterial transmission. The emergence of bacterial transmission, including multi-drug resistance (MDR) bacteria, during Hajj has not been systematically assessed. METHODS: Articles in Pubmed, Scopus, and Google scholar were identified using controlled words relating to antibiotic resistance (AR) at the Hajj from January 2002 to January 2017. Eligible studies were identified by two researchers...
June 23, 2017: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/28642846/decreased-fitness-and-virulence-in-st10-escherichia-coli-harboring-blandm-5-and-mcr-1-against-a-st4981-strain-with-blandm-5
#18
Yawei Zhang, Kang Liao, Hua Gao, Qi Wang, Xiaojuan Wang, Henan Li, Ruobing Wang, Hui Wang
Although coexistence of blaNDM-5 and mcr-1 in Escherichia coli has been reported, little is known about the fitness and virulence of such strains. Three carbapenem-resistant Escherichia coli (GZ1, GZ2, and GZ3) successively isolated from one patient in 2015 were investigated for microbiological fitness and virulence. GZ1 and GZ2 were also resistant to colistin. To verify the association between plasmids and fitness, growth kinetics of the transconjugants were performed. We also analyzed genomic sequences of GZ2 and GZ3 using PacBio sequencing...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28640456/first-environmental-sample-containing-plasmid-mediated-colistin-resistant-esbl-producing-escherichia-coli-detected-in-norway
#19
Silje Bakken Jørgensen, Arne Søraas, Lotte Stenfors Arnesen, Truls Leegaard, Arnfinn Sundsfjord, Pål A Jenum
We hereby report a detection of the plasmid borne mcr-1 gene conferring colistin resistance in an extended-spectrum β-lactamase (ESBL) producing Escherichia coli ST10 strain retrieved from seawater at a public beach in Norway. The sample was collected in September 2010 and was investigated by whole-genome sequencing in 2016. This report illustrates that E. coli strains carrying plasmid-mediated colistin resistance genes have also reached areas where this drug is hardly used at all. Surveillance of colistin resistance in environmental, veterinary, and human strains is warranted also in countries where colistin resistance is rare in clinical settings...
June 22, 2017: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/28628439/locally-acquired-mcr-1-in-escherichia-coli-australia-2011-and-2013
#20
Justin A Ellem, Andrew N Ginn, Sharon C-A Chen, John Ferguson, Sally R Partridge, Jonathan R Iredell
We identified discrete importation events of the mcr-1 gene on incompatibility group IncI2 plasmids in Escherichia coli isolated from patients in New South Wales, Australia, in 2011 and 2013. mcr-1 is present in a small minority of colistin-resistant Enterobacteriaceae and appears not to be established locally.
July 2017: Emerging Infectious Diseases
keyword
keyword
85062
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"