keyword
https://read.qxmd.com/read/38535332/association-between-protein-intake-and-diabetes-complications-risk-following-incident-type-2-diabetes-the-epic-potsdam-study
#1
JOURNAL ARTICLE
Elif Inan-Eroglu, Olga Kuxhaus, Franziska Jannasch, Daniela V Nickel, Matthias B Schulze
Our knowledge about the connection between protein intake and diabetes-related complications comes largely from studies among those already diagnosed with type 2 diabetes (T2D). However, there is a lack of information on whether changing protein intake after diabetes diagnosis affects complications risk. We aimed to explore the association between protein intake (total, animal, and plant) and vascular complications in incident T2D patients considering pre-diagnosis intake and changes in intake after diagnosis...
March 19, 2024: Metabolites
https://read.qxmd.com/read/38533084/forward-genetic-screen-using-a-gene-breaking-trap-approach-identifies-a-novel-role-of-grin2bb-associated-rna-transcript-grin2bbart-in-zebrafish-heart-function
#2
JOURNAL ARTICLE
Ramcharan Singh Angom, Adita Joshi, Ashok Patowary, Ambily Sivadas, Soundhar Ramasamy, Shamsudheen K V, Kriti Kaushik, Ankit Sabharwal, Mukesh Kumar Lalwani, Subburaj K, Naresh Singh, Vinod Scaria, Sridhar Sivasubbu
LncRNA-based control affects cardiac pathophysiologies like myocardial infarction, coronary artery disease, hypertrophy, and myotonic muscular dystrophy. This study used a gene-break transposon (GBT) to screen zebrafish ( Danio rerio ) for insertional mutagenesis. We identified three insertional mutants where the GBT captured a cardiac gene. One of the adult viable GBT mutants had bradycardia (heart arrhythmia) and enlarged cardiac chambers or hypertrophy; we named it "bigheart." Bigheart mutant insertion maps to grin2bb or N-methyl D-aspartate receptor (NMDAR2B) gene intron 2 in reverse orientation...
2024: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/38528542/association-of-sodium-glucose-cotransporter-2-inhibitors-with-risk-of-major-adverse-cardiovascular-events-in-type-2-diabetes-patients-with-acute-coronary-syndrome-a-propensity-score%C3%A2-matched-analysis
#3
JOURNAL ARTICLE
Tao Liu, Zeyuan Fan, Bing Xiao, Chang He, Shicong Wang
BACKGROUND: This study aimed to investigate the association of sodium-glucose cotransporter 2 inhibitors (SGLT2i) use with cardiovascular (CV) clinical outcomes in type 2 diabetes (T2D) patients with acute coronary syndrome (ACS). METHODS: Data of T2D patients hospitalized for ACS at Civil Aviation General Hospital from January 2019 to December 2022 were collected. Based on SGLT2i use or not, patients were stratified as SGLT2i group and SGLT2i-free group. A 1:1 nearest-neighbor propensity score-matched (PSM) was performed to adjust for the confounding factors and facilitate the robust comparisons between groups...
March 25, 2024: Cardiovascular Diabetology
https://read.qxmd.com/read/38527579/time-to-tweak-the-definition-of-type-2-myocardial-infarction
#4
EDITORIAL
John A Ambrose, Richard Kiel, Asseel AlBayati
The Universal definition (UD) of Myocardial Infarction (MI) has been an important contribution to the literature and has, among other aims, helped explain the significance of elevated troponin levels. The clinician caring for patients admitted to the hospital must determine the etiology of the troponin elevation and whether or not it meets criteria for acute MI. The concept of a Type 2 MI- an MI due to a supply/demand mismatch and not to athero thrombosis is one of the most important contributions of the UD...
March 23, 2024: American Journal of Cardiology
https://read.qxmd.com/read/38525540/the-role-of-nano-systems-in-the-delivery-of-glucose-lowering-drugs-for-the-pre-emption-and-treatment-of-diabetes-associated-atherosclerosis
#5
REVIEW
Luke James Conroy, Alyssa McCann, Nan Zhang, Monica de Gaetano
Diabetes is one of the most prevalent diseases worldwide. In recent decades, type-2 diabetes has become increasingly common, particularly in younger individuals. Diabetes leads to many vascular complications, including atherosclerosis. Atherosclerosis is a cardiovascular disease characterized by lipid-rich plaques within the vasculature. Plaques develop over time, restricting blood flow; and can therefore be the underlying cause of major adverse cardiovascular events, including myocardial infarction and stroke...
March 25, 2024: American Journal of Physiology. Cell Physiology
https://read.qxmd.com/read/38523952/comparison-of-cardiovascular-outcomes-and-all-cause-mortality-between-patients-with-and-without-epilepsy-a-systematic-review-and-meta-analysis-of-observational-studies
#6
REVIEW
Azrung Fayaz, Mehnahil Raza, Areeba Khan, Pranav Mohandas, Hailegiorgis Getnet Ayalew, Prinka Perswani, Calvin R Wei, Mahmoud Ahmed Abdelbaki
This meta-analysis aimed to assess the all-cause mortality and cardiovascular outcomes among patients diagnosed with epilepsy. The entire process of this systematic review and meta-analysis adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines to ensure transparency and reporting completeness. A comprehensive search strategy was employed to identify relevant studies in electronic databases, including PubMed, Embase, and the Cumulative Index of Nursing and Allied Health Literature (CINAHL), from January 1, 2010, to January 15, 2024...
February 2024: Curēus
https://read.qxmd.com/read/38523465/prediction-of-cardiovascular-and-renal-risk-among-patients-with-apparent-treatment-resistant-hypertension-in-the-united-states-using-machine-learning-methods
#7
JOURNAL ARTICLE
George Bakris, Pei Paul Lin, Chang Xu, Cindy Chen, Veronica Ashton, Mukul Singhal
Apparent treatment-resistant hypertension (aTRH), defined as blood pressure (BP) that remains uncontrolled despite unconfirmed concurrent treatment with three antihypertensives, is associated with an increased risk of developing cardiovascular and renal complications compared with controlled hypertension. We aimed to identify the characteristics of aTRH patients with an elevated risk of major adverse cardiovascular events plus (MACE+; defined as stroke, myocardial infarction, or heart failure hospitalization) and end stage renal disease (ESRD)...
March 24, 2024: Journal of Clinical Hypertension
https://read.qxmd.com/read/38517999/the-impact-of-the-2019-esc-eas-dyslipidaemia-guidelines-on-real-world-initial-lipid-lowering-therapy-in-patients-with-acute-myocardial-infarction
#8
JOURNAL ARTICLE
Xiangqi Kong, Gang He, Xiaoqing Quan, Zhixiong Tan, Fengjuan Yan, Xiehui Chen
This study aimed to investigate the impact of the latest guidelines on the real-world clinical practice of initial lipid-lowering therapy, especially on the use of ezetimibe and proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors in China. All adult patients diagnosed with acute myocardial infarction in our hospital between August 31, 2018, and August 31, 2020, were divided into the following 2 groups: those patients treated before the latest guideline release, and those patients treated after the release...
March 22, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38517926/incidence-of-type-2-diabetes-cardiovascular-disease-and-chronic-kidney-disease-in-patients-with-multiple-sclerosis-initiating-disease-modifying-therapies-retrospective-cohort-study-using-a-frequentist-model-averaging-statistical-framework
#9
JOURNAL ARTICLE
Alan J M Brnabic, Sarah E Curtis, Joseph A Johnston, Albert Lo, Anthony J Zagar, Ilya Lipkovich, Zbigniew Kadziola, Megan H Murray, Timothy Ryan
Researchers are increasingly using insights derived from large-scale, electronic healthcare data to inform drug development and provide human validation of novel treatment pathways and aid in drug repurposing/repositioning. The objective of this study was to determine whether treatment of patients with multiple sclerosis with dimethyl fumarate, an activator of the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway, results in a change in incidence of type 2 diabetes and its complications. This retrospective cohort study used administrative claims data to derive four cohorts of adults with multiple sclerosis initiating dimethyl fumarate, teriflunomide, glatiramer acetate or fingolimod between January 2013 and December 2018...
2024: PloS One
https://read.qxmd.com/read/38517762/metformin-use-in-type-2-diabetics-and-delirium-after-noncardiac-surgery-a-retrospective-cohort-analysis
#10
JOURNAL ARTICLE
Stephania Paredes, Ayoub Harb, Julian Rössler, Maede Zookaei Nikoo, Kurt Ruetzler, Alparslan Turan, Xuan Pu, Daniel I Sessler
INTRODUCTION: The cause of postoperative delirium is unknown, but it is thought to result at least in part from inflammation. Metformin, besides its hypoglycemic properties, demonstrates anti-inflammatory effects systemically and in the brain. We tested the primary hypothesis that chronic metformin use in adults with type 2 diabetes is associated with less delirium during the first 5 days after major noncardiac surgery. Secondary outcomes were a composite of serious complications (myocardial infarction, cardiac arrest, stage 2-3 acute kidney injury [AKI], and mortality) and time to discharge alive...
March 22, 2024: Anesthesia and Analgesia
https://read.qxmd.com/read/38515365/ischemia-induced-cardiac-dysfunction-is-exacerbated-in-adiponectin-knockout-mice-due-to-impaired-autophagy-flux
#11
JOURNAL ARTICLE
Hye Kyoung Sung, Jialing Tang, James Won Suk Jahng, Erfei Song, Yee Kwan Chan, Abdul Hadee Lone, Jeffrey Peterson, Ali Abdul-Sater, Gary Sweeney
Strategies to enhance autophagy flux have been suggested to improve outcomes in cardiac ischemic models. We explored the role of adiponectin in mediating cardiac autophagy under ischemic conditions induced by permanent coronary artery ligation. We studied the molecular mechanisms underlying adiponectin's cardio-protective effects in adiponectin knockout (Ad-KO) compared with wild-type (WT) mice subjected to ischemia by coronary artery ligation and H9c2 cardiomyocyte cell line exposed to hypoxia. Systemic infusion of a cathepsin-B activatable near-infrared probe as a biomarker for autophagy and detection via noninvasive three-dimensional fluorescence molecular tomography combined with computerized tomography to quantitate temporal changes, indicated increased activity in the myocardium of WT mice after myocardial infarction which was attenuated in Ad-KO...
March 2024: Clinical and Translational Science
https://read.qxmd.com/read/38514330/-the-diagnostic-value-of-genetic-testing-in-familial-hypercholesterolemia-in-patients-with-premature-myocardial-infarction
#12
JOURNAL ARTICLE
Y X Cui, J X Song, Z Y Li, S F Li, C F Liu, H Chen
Objective: To evaluate the diagnostic value of gene testing in familial hypercholesterolemia (FH) in patients with premature myocardial infarction(PMI). Methods: This study was a single center cross-sectional study. A retrospective analysis was made on PMI patients who visited the People's Hospital of Peking University from May 1, 2015 to March 31, 2017. Clinical data of patients was collected and gene testing of FH related genes low density lipoprotein receptor (LDLR), proprotein convertase subtilisin/kexin type 9 (PCSK9), apolipoprotein B(APOB) and low density lipoprotein receptor adaptor protein 1(LDLRAP1) was carried out...
March 24, 2024: Zhonghua Xin Xue Guan Bing za Zhi
https://read.qxmd.com/read/38513436/effects-of-alirocumab-on-endothelial-function-and-coronary-atherosclerosis-in-myocardial-infarction-a-pacman-ami-randomized-clinical-trial-substudy
#13
JOURNAL ARTICLE
Emrush Rexhaj, Sarah Bär, Rodrigo Soria, Yasushi Ueki, Jonas D Häner, Tatsuhiko Otsuka, Raminta Kavaliauskaite, George Cm Siontis, Stefan Stortecky, Hiroki Shibutani, David Spirk, Thomas Engstrøm, Irene Lang, Laura Morf, Maria Ambühl, Stephan Windecker, Sylvain Losdat, Konstantinos C Koskinas, Lorenz Räber
BACKGROUND AND AIMS: The effects of protein convertase subtilisin/kexin type 9 (PCSK9) inhibitors on endothelial function as assessed by flow-mediated dilation (FMD) in patients with acute myocardial infarction (AMI) are unknown. Therefore, we aimed to investigate the effects of the PCSK9 inhibitor alirocumab added to high-intensity statin on FMD, and its association with coronary atherosclerosis in non-infarct related arteries using intracoronary intravascular ultrasound (IVUS), near-infrared spectroscopy (NIRS), and optical coherence tomography (OCT)...
March 6, 2024: Atherosclerosis
https://read.qxmd.com/read/38510954/trends-in-the-incidence-and-in-patient-outcomes-of-acute-myocardial-infarction-in-pregnancy-insights-from-the-national-inpatient-sample
#14
JOURNAL ARTICLE
Favour Markson, Rimaskep Garba Shamaki, Akanimo Antia, Anita Osabutey, Modele O Ogunniyi
STUDY OBJECTIVE: Pregnancy-related morbidity and mortality rates in the United States are rising despite advances in knowledge, technology, and healthcare delivery. Cardiovascular disease is the leading cause of adverse pregnancy outcomes, with acute myocardial infarction (AMI) being a potential contributor to the worse outcomes in pregnancy. DESIGN/SETTING: We analyzed data from the national inpatient sample database to examine trends in the incidence and in-hospital outcomes of myocardial infarction in pregnancy from 2016 to 2020...
October 2023: American heart journal plus: cardiology research and practice
https://read.qxmd.com/read/38509493/analysis-of-the-incidence-and-risk-factors-of-blood-transfusion-in-total-knee-revision-a-retrospective-nationwide-inpatient-sample-database-study
#15
JOURNAL ARTICLE
Xiaoyin Li, Hao Xie, Shuxia Liu, Jian Wang, Zhanjun Shi, Qiaobing Yao, Qinfeng Yang, Qiuhong Li, Liangxiao Bao
OBJECTIVE: This study sought to determine the incidence and risk factors of blood transfusion among patients undergoing total knee revision (TKR) using a nationwide database. METHODS: A retrospective data analysis was conducted based on the Nationwide Inpatient Sample (NIS), enrolling patients who underwent TKR from 2010 to 2019 with complete information. The patients were divided into two groups based on whether they received blood transfusion or not. The demographic characteristics (race, sex, and age), length of stay (LOS), total charge of hospitalization, hospital characteristics (admission type, insurance type, bed size, teaching status, location, and region of hospital), hospital mortality, comorbidities, and perioperative complications were analyzed...
March 20, 2024: BMC Musculoskeletal Disorders
https://read.qxmd.com/read/38509341/effectiveness-and-safety-of-empagliflozin-final-results-from-the-emprise-study
#16
JOURNAL ARTICLE
Phyo T Htoo, Helen Tesfaye, Sebastian Schneeweiss, Deborah J Wexler, Brendan M Everett, Robert J Glynn, Niklas Schmedt, Lisette Koeneman, Anouk Déruaz-Luyet, Julie M Paik, Elisabetta Patorno
AIMS/HYPOTHESIS: Limited evidence exists on the comparative safety and effectiveness of empagliflozin against alternative glucose-lowering medications in individuals with type 2 diabetes with the broad spectrum of cardiovascular risk. The EMPagliflozin compaRative effectIveness and SafEty (EMPRISE) cohort study was designed to monitor the safety and effectiveness of empagliflozin periodically for a period of 5 years with data collection from electronic healthcare databases. METHODS: We identified individuals ≥18 years old with type 2 diabetes who initiated empagliflozin or dipeptidyl peptidase-4 inhibitors (DPP-4i) from 2014 to 2019 using US Medicare and commercial claims databases...
March 21, 2024: Diabetologia
https://read.qxmd.com/read/38508987/effects-of-remote-ischaemic-conditioning-in-stable-and-unstable-angina-patients-undergoing-percutaneous-coronary-intervention-a-systematic-review-and-meta-analysis
#17
REVIEW
Wilbert Huang, Alvin Frederich, Alizha Rochana Putri
AIM: Type 4a myocardial infarction (T4aMI), defined as myocardial injury associated with percutaneous coronary intervention (PCI), is associated with a poor prognosis and there is conflicting evidence regarding the effectiveness of remote ischaemic conditioning (RIC) in its prevention. This review aimed to determine the effect of RIC on stable and unstable angina patients. METHOD: A systematic review was conducted in PubMed and Central database. Outcome measures were: changes in peak troponin, creatine kinase myocardial band (CKMB), C-reactive protein (CRP) level, incidence of T4aMI, and major adverse cardiovascular event (MACE)...
March 19, 2024: Heart, Lung & Circulation
https://read.qxmd.com/read/38508632/finerenone-cardiovascular-and-kidney-outcomes-by-age-and-sex-fidelity-post-hoc-analysis-of-two-phase-3-multicentre-double-blind-trials
#18
RANDOMIZED CONTROLLED TRIAL
Shweta Bansal, Maria E F Canziani, Rita Birne, Stefan D Anker, George L Bakris, Gerasimos Filippatos, Peter Rossing, Luis M Ruilope, Alfredo E Farjat, Peter Kolkhof, Andrea Lage, Meike Brinker, Bertram Pitt
OBJECTIVES: This study aimed to evaluate the efficacy and safety of finerenone, a selective, non-steroidal mineralocorticoid receptor antagonist, on cardiovascular and kidney outcomes by age and/or sex. DESIGN: FIDELITY post hoc analysis; median follow-up of 3 years. SETTING: FIDELITY: a prespecified analysis of the FIDELIO-DKD and FIGARO-DKD trials. PARTICIPANTS: Adults with type 2 diabetes and chronic kidney disease receiving optimised renin-angiotensin system inhibitors (N=13 026)...
March 19, 2024: BMJ Open
https://read.qxmd.com/read/38506815/type-2-myocardial-infarction-poorly-understood-underevaluated-and-too-often-ignored
#19
JOURNAL ARTICLE
James A de Lemos, Bertil Lindahl, Nicholas L Mills
No abstract text is available yet for this article.
March 20, 2024: JAMA Cardiology
https://read.qxmd.com/read/38504170/ticagrelor-monotherapy-after-a-short-course-of-dual-antiplatelet-therapy-with-ticagrelor-plus-aspirin-following-percutaneous-coronary-intervention-in-patients-with-versus-without-diabetes-mellitus-a-meta-analysis-of-randomized-trials
#20
JOURNAL ARTICLE
Chen Ning, Fang Ling, Deyi Liu, Zhang Zhi
BACKGROUND: Cardiovascular disease (CVD) is one among the major causes of mortality all round the globe. Several anti-platelet regimens have been proposed following percutaneous coronary intervention (PCI). In this analysis, we aimed to show the adverse clinical outcomes associated with ticagrelor monotherapy after a short course of dual antiplatelet therapy (DAPT) with ticagrelor and aspirin following PCI in patients with versus without diabetes mellitus (DM). METHODS: Electronic databases were searched by four authors from September to November 2023...
March 19, 2024: BMC Cardiovascular Disorders
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