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melatonin seasonal affective disorder

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https://www.readbyqxmd.com/read/28612993/melatonin-as-a-treatment-for-mood-disorders-a-systematic-review
#1
F De Crescenzo, A Lennox, J C Gibson, J H Cordey, S Stockton, P J Cowen, D J Quested
OBJECTIVE: Melatonin has been widely studied in the treatment of sleep disorders and evidence is accumulating on a possible role for melatonin influencing mood. Our aim was to determine the efficacy and acceptability of melatonin for mood disorders. METHOD: We conducted a comprehensive systematic review of randomized clinical trials on patients with mood disorders, comparing melatonin to placebo. RESULTS: Eight clinical trials were included; one study in bipolar, three in unipolar depression and four in seasonal affective disorder...
June 14, 2017: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/28526480/human-seasonal-and-circadian-studies-in-antarctica-halley-75-0-s
#2
Josephine Arendt, Benita Middleton
Living for extended periods in Antarctica exposes base personnel to extremes of daylength (photoperiod) and temperature. At the British Antarctic Survey base of Halley, 75(0)S, the sun does not rise for 110 d in the winter and does not set for 100 d in summer. Photoperiod is the major time cue governing the timing of seasonal events such as reproduction in many species. The neuroendocrine signal providing photoperiodic information to body physiology is the duration of melatonin secretion which reflects the length of the night: longer in the short days of winter and shorter in summer...
May 16, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28511899/signaling-pathways-to-and-from-the-hypophysial-pars-tuberalis-an-important-center-for-the-control-of-seasonal-rhythms
#3
REVIEW
Horst-Werner Korf
Seasonal (circannual) rhythms play an important role for the control of body functions (reproduction, metabolism, immune responses) in nearly all living organisms. Also humans are affected by the seasons with regard to immune responses and mental functions, the seasonal affective disorder being one of the most prominent examples. The hypophysial pars tuberalis (PT), an important interface between the hypophysial pars distalis and neuroendocrine centers in the brain, plays an essential role in the regulation of seasonal functions and may even be the seat of the circannual clock...
May 13, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28012610/secondary-to-excessive-melatonin-synthesis-the-consumption-of-tryptophan-from-outside-the-blood-brain-barrier-and-melatonin-over-signaling-in-the-pars-tuberalis-may-be-central-to-the-pathophysiology-of-winter-depression
#4
José Carlos Pereira, Márcia Pradella Hallinan, Rosana Cardoso Alves
Seasonal affective disorder is defined as recurrent episodes of major depression, mania, or hypomania with seasonal onset and remission. In this class of mood disturbances, a unipolar major depressive disorder known as winter depression is common in populations living in northern latitudes far from the equator. Winter depression repeatedly occurs in the autumn or winter and remits in the spring or summer, and its etiopathogenesis is currently unknown. However, one can surmise that excessive melatonin production during the reduced duration of daily sunlight in the autumn and winter plays a role in its pathophysiology...
January 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/27821114/bright-light-therapy-in-pregnant-women-with-major-depressive-disorder-study-protocol-for-a-randomized-double-blind-controlled-clinical-trial
#5
RANDOMIZED CONTROLLED TRIAL
Babette Bais, Astrid M Kamperman, Marjolein D van der Zwaag, Gwen C Dieleman, Hanneke W Harmsen van der Vliet-Torij, Hilmar H Bijma, Ritsaert Lieverse, Witte J G Hoogendijk, Mijke P Lambregtse-van den Berg
BACKGROUND: Depression during pregnancy is a common and high impact disease. Generally, 5-10 % of pregnant women suffer from depression. Children who have been exposed to maternal depression during pregnancy have a higher risk of adverse birth outcomes and more often show cognitive, emotional and behavioural problems. Therefore, early detection and treatment of antepartum depression is necessary. Both psychotherapy and antidepressant medication, first choice treatments in a non-pregnant population, have limitations in treating depression during pregnancy...
November 8, 2016: BMC Psychiatry
https://www.readbyqxmd.com/read/27068698/molecular-basis-for-regulating-seasonal-reproduction-in-vertebrates
#6
REVIEW
Taeko Nishiwaki-Ohkawa, Takashi Yoshimura
Animals that inhabit mid- to high-latitude regions exhibit various adaptive behaviors, such as migration, reproduction, molting and hibernation in response to seasonal cues. These adaptive behaviors are tightly regulated by seasonal changes in photoperiod, the relative day length vs night length. Recently, the regulatory pathway of seasonal reproduction has been elucidated using quail. In birds, deep brain photoreceptors receive and transmit light information to the pars tuberalis in the pituitary gland, which induces the secretion of thyroid-stimulating hormone...
June 2016: Journal of Endocrinology
https://www.readbyqxmd.com/read/26938817/state-of-the-art-psychopharmacological-treatment-options-in-seasonal-affective-disorder
#7
REVIEW
Mesut Yildiz, Sedat Batmaz, Emrah Songur, Esat Timuçin Oral
Seasonal affective disorder (SAD) is defined as a subtype of mood disorders in DSM 5, and it is characterized by a seasonal onset. SAD is proposed to be related to the seasonal changes in naturally occurring light, and the use of bright light therapy for depressive symptoms has been shown to reduce them in placebo controlled trials. Cognitive behavioral therapy has also been demonstrated to be effective in SAD. This review article aims to focus on the psychopharmacological treatment options for SAD. According to clinical trial results, first line treatment options seem to be sertraline and fluoxetine, and are well tolerated by the patients...
March 2016: Psychiatria Danubina
https://www.readbyqxmd.com/read/26560173/melatonin-and-agomelatine-for-preventing-seasonal-affective-disorder
#8
REVIEW
Angela Kaminski-Hartenthaler, Barbara Nussbaumer, Catherine A Forneris, Laura C Morgan, Bradley N Gaynes, Jeffrey H Sonis, Amy Greenblatt, Jörg Wipplinger, Linda J Lux, Dietmar Winkler, Megan G Van Noord, Julia Hofmann, Gerald Gartlehner
BACKGROUND: Seasonal affective disorder (SAD) is a seasonal pattern of recurrent major depressive episodes that most commonly occurs during autumn or winter and remits in spring. The prevalence of SAD in the United States ranges from 1.5% to 9%, depending on latitude. The predictable seasonal aspect of SAD provides a promising opportunity for prevention. This is one of four reviews on the efficacy and safety of interventions to prevent SAD; we focus on agomelatine and melatonin as preventive interventions...
2015: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/26560172/psychological-therapies-for-preventing-seasonal-affective-disorder
#9
REVIEW
Catherine A Forneris, Barbara Nussbaumer, Angela Kaminski-Hartenthaler, Laura C Morgan, Bradley N Gaynes, Jeffrey H Sonis, Amy Greenblatt, Jörg Wipplinger, Linda J Lux, Dietmar Winkler, Megan G Van Noord, Julia Hofmann, Gerald Gartlehner
BACKGROUND: Seasonal affective disorder (SAD) is a seasonal pattern of recurrent major depressive episodes that most commonly occurs during autumn or winter and remits in spring. The prevalence of SAD ranges from 1.5% to 9%, depending on latitude. The predictable seasonal aspect of SAD provides a promising opportunity for prevention. This is one of four reviews on the efficacy and safety of interventions to prevent SAD; we focus on psychological therapies as preventive interventions. OBJECTIVES: To assess the efficacy and safety of psychological therapies (in comparison with no treatment, other types of psychological therapy, second-generation antidepressants (SGAs), light therapy, melatonin or agomelatine or lifestyle interventions) in preventing SAD and improving patient-centred outcomes among adults with a history of SAD...
2015: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/26558494/light-therapy-for-preventing-seasonal-affective-disorder
#10
REVIEW
Barbara Nussbaumer, Angela Kaminski-Hartenthaler, Catherine A Forneris, Laura C Morgan, Jeffrey H Sonis, Bradley N Gaynes, Amy Greenblatt, Jörg Wipplinger, Linda J Lux, Dietmar Winkler, Megan G Van Noord, Julia Hofmann, Gerald Gartlehner
BACKGROUND: Seasonal affective disorder (SAD) is a seasonal pattern of recurrent major depressive episodes that most commonly occurs during autumn or winter and remits in spring. The prevalence of SAD ranges from 1.5% to 9%, depending on latitude. The predictable seasonal aspect of SAD provides a promising opportunity for prevention. This review - one of four reviews on efficacy and safety of interventions to prevent SAD - focuses on light therapy as a preventive intervention. Light therapy is a non-pharmacological treatment that exposes people to artificial light...
November 8, 2015: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/26558418/second-generation-antidepressants-for-preventing-seasonal-affective-disorder-in-adults
#11
REVIEW
Gerald Gartlehner, Barbara Nussbaumer, Bradley N Gaynes, Catherine A Forneris, Laura C Morgan, Angela Kaminski-Hartenthaler, Amy Greenblatt, Jörg Wipplinger, Linda J Lux, Jeffrey H Sonis, Julia Hofmann, Megan G Van Noord, Dietmar Winkler
BACKGROUND: Seasonal affective disorder (SAD) is a seasonal pattern of recurrent major depressive episodes that most commonly occurs during autumn or winter and remits in spring. The prevalence of SAD ranges from 1.5% to 9%, depending on latitude. The predictable seasonal aspect of SAD provides a promising opportunity for prevention. This review - one of four reviews on efficacy and safety of interventions to prevent SAD - focuses on second-generation antidepressants (SGAs). OBJECTIVES: To assess the efficacy and safety of second-generation antidepressants (in comparison with other SGAs, placebo, light therapy, melatonin or agomelatine, psychological therapies or lifestyle interventions) in preventing SAD and improving patient-centred outcomes among adults with a history of SAD...
November 8, 2015: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/26359987/melatonin-contributes-to-the-seasonality-of-multiple-sclerosis-relapses
#12
Mauricio F Farez, Ivan D Mascanfroni, Santiago P Méndez-Huergo, Ada Yeste, Gopal Murugaiyan, Lucien P Garo, María E Balbuena Aguirre, Bonny Patel, María C Ysrraelit, Chen Zhu, Vijay K Kuchroo, Gabriel A Rabinovich, Francisco J Quintana, Jorge Correale
Seasonal changes in disease activity have been observed in multiple sclerosis, an autoimmune disorder that affects the CNS. These epidemiological observations suggest that environmental factors influence the disease course. Here, we report that melatonin levels, whose production is modulated by seasonal variations in night length, negatively correlate with multiple sclerosis activity in humans. Treatment with melatonin ameliorates disease in an experimental model of multiple sclerosis and directly interferes with the differentiation of human and mouse T cells...
September 10, 2015: Cell
https://www.readbyqxmd.com/read/26348075/changes-in-melatonin-synthesis-parameters-after-carbon-monoxide-concentration-increase-in-the-cavernous-sinus
#13
M Romerowicz-Misielak, D A Oren, M Sowa-Kucma, A Tabecka-Lonczynska, P Gilun, S Stefanczyk-Krzymowska, M Koziorowski
Previous studies indicate that the gaseous messenger carbon monoxide (CO) is released from the eye into the ophthalmic venous blood depending on the intensity of sunlight. This study was designed to determine whether the increased concentration of CO in ophthalmic venous blood affects the synthesis of melatonin and therefore, whether CO released from the eye under normal lighting conditions can be a carrier of light intensity information. Thirty six mature male wild boar and pig crossbreeds (n = 36) were studied...
August 2015: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/26025242/seasonal-heat-stress-clinical-implications-and-hormone-treatments-for-the-fertility-of-dairy-cows
#14
REVIEW
F De Rensis, I Garcia-Ispierto, F López-Gatius
Heat stress has consequences on both the physiology and reproductive performance of cows, but the most dramatic effect for dairy producers is the decrease produced in fertility. The effects of heat stress on fertility include an increased number of days open, reduced conception rate, and larger number of cows suffering different types of anestrus. Once becomes pregnant, heat stress affects also the reproductive success of the cow through its direct effects on the ovary, uterus, gametes, embryo, and early fetus...
September 15, 2015: Theriogenology
https://www.readbyqxmd.com/read/25959961/photoperiod-programs-dorsal-raphe-serotonergic-neurons-and-affective-behaviors
#15
Noah H Green, Chad R Jackson, Hideki Iwamoto, Michael C Tackenberg, Douglas G McMahon
The serotonergic raphe nuclei of the midbrain are principal centers from which serotonin neurons project to innervate cortical and sub-cortical structures. The dorsal raphe nuclei receive light input from the circadian visual system and indirect input from the biological clock nuclei. Dysregulation of serotonin neurotransmission is implicated in neurobehavioral disorders, such as depression and anxiety, and alterations in the serotonergic phenotype of raphe neurons have dramatic effects on affective behaviors in rodents...
May 18, 2015: Current Biology: CB
https://www.readbyqxmd.com/read/25515595/melatonin-adjusts-the-expression-pattern-of-clock-genes-in-the-suprachiasmatic-nucleus-and-induces-antidepressant-like-effect-in-a-mouse-model-of-seasonal-affective-disorder
#16
Andras David Nagy, Ayaka Iwamoto, Misato Kawai, Ryosei Goda, Haruka Matsuo, Tsuyoshi Otsuka, Mao Nagasawa, Mitsuhiro Furuse, Shinobu Yasuo
Recently, we have shown that C57BL/6J mice exhibit depression-like behavior under short photoperiod and suggested them as an animal model for investigating seasonal affective disorder (SAD). In this study, we tested if manipulations of the circadian clock with melatonin treatment could effectively modify depression-like and anxiety-like behaviors and brain serotonergic system in C57BL/6J mice. Under short photoperiods (8-h light/16-h dark), daily melatonin treatments 2 h before light offset have significantly altered the 24-h patterns of mRNA expression of circadian clock genes (per1, per2, bmal1 and clock) within the suprachiasmatic nuclei (SCN) mostly by increasing amplitude in their expressional rhythms without inducing robust phase shifts in them...
May 2015: Chronobiology International
https://www.readbyqxmd.com/read/25282989/creating-the-right-light-for-older-people
#17
Carl Gardner
In last month's HEJ first we ran the first of a two-part focus, by Carl Gardner, former editor of the Institution of Lighting Professionals' Lighting Journal, on the issues surrounding lighting and the ageing population, which focused particularly on effective task lighting. In the second part of the article, the author considers the important psychological, physiological, and biological effects of lighting on older people--and how improved lighting design can benefit this group in a number of ways.
September 2014: Health Estate
https://www.readbyqxmd.com/read/24588832/chronobiology-of-the-neuroimmunoendocrine-system-and-aging
#18
REVIEW
Ianire Mate, Juan Antonio Madrid, Mónica De la Fuente
The health maintenance depends on the preservation of the homeostatic systems, such as nervous, endocrine and immune system, and a proper communication between them. In this regard, the circadian system, which promotes a better physiological system functions and thus well being, could be considered part of that homeostatic complex, since the neuroimmunoendocrine system possesses circadian patterns in most variables, as well as circannual or seasonal variations. With aging, an impairment of the homeostatic systems occurs and an alteration of circadian system regulation has been demonstrated...
2014: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/24156411/molecular-docking-studies-for-the-identification-of-novel-melatoninergic-inhibitors-for-acetylserotonin-o-methyltransferase-using-different-docking-routines
#19
Syed Sikander Azam, Sumra Wajid Abbasi
BACKGROUND: N-Acetylserotonin O-methyltransferase (ASMT) is an enzyme which by converting nor-melatonin to melatonin catalyzes the final reaction in melatonin biosynthesis in tryptophan metabolism pathway. High Expression of ASMT gene is evident in PPTs. The presence of abnormally high levels of ASMT in pineal gland could serve as an indication of the existence of pineal parenchymal tumors (PPTs) in the brain (J Neuropathol Exp Neurol 65: 675-684, 2006). Different levels of melatonin are used as a trait marker for prescribing the mood disorders e...
2013: Theoretical Biology & Medical Modelling
https://www.readbyqxmd.com/read/23909693/manipulating-melatonin-in-managing-mood
#20
REVIEW
P Boyce, M Hopwood
OBJECTIVE: Disturbances in circadian rhythms have been associated with major depression and may be an underlying mechanism for the disorder. Resynchronisation of circadian rhythms may provide a new approach to treatment, especially by manipulating melatonin secretion. Melatonin is secreted at night and is a stable marker of circadian rhythms. The timing of its secretion can be changed by exogenous melatonin, agonism of specific melatonin receptors in the suprachiasmatic nucleus, its suppression by light and by sleep deprivation...
2013: Acta Psychiatrica Scandinavica. Supplementum
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