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https://www.readbyqxmd.com/read/28192852/effective-disengagement-insecure-people-are-more-likely-to-disengage-from-an-ongoing-task-and-take-effective-action-when-facing-danger
#1
Tsachi Ein-Dor, Adi Perry-Paldi, Jenna Merrin, Yaniv Efrati, Gilad Hirschberger
OBJECTIVE: People believe that they can respond effectively to threats, but actually experience difficulties in disengaging from ongoing tasks and shifting their attention to life-threatening events. We contend that this tendency is especially true for secure people with respect to their worldview and perception of others and not to insecure individuals. METHOD: In Study 1 (N=290), we examined individuals' reactions to various threat scenarios. In Study 2 (N=65), we examined these reactions using a behavioral design high in ecological validity...
February 13, 2017: Journal of Personality
https://www.readbyqxmd.com/read/28182298/looking-into-the-puparium-micro-ct-visualization-of-the-internal-morphological-changes-during-metamorphosis-of-the-blow-fly-calliphora-vicina-with-the-first-quantitative-analysis-of-organ-development-in-cyclorrhaphous-dipterans
#2
Daniel Martín-Vega, Thomas J Simonsen, Martin J R Hall
Metamorphosis of cyclorrhaphous flies takes place inside a barrel-like puparium, formed by the shrinking, hardening and darkening of the third-instar larval cuticle. The opacity of this structure hampers the visualization of the morphological changes occurring inside and therefore a full understanding of the metamorphosis process. Here, we use micro-computed tomography (micro-CT) to describe the internal morphological changes that occur during metamorphosis of the blow fly, Calliphora vicina Robineau-Desvoidy 1830 (Diptera: Calliphoridae) at a greater temporal resolution than anything hitherto published...
February 9, 2017: Journal of Morphology
https://www.readbyqxmd.com/read/28170271/quantification-and-qualitative-effects-of-different-pegylations-on-pbca-nanoparticles
#3
Andreas K O Åslund, Einar Sulheim, Sofie Snipstad, Eva von Haartman, Habib Baghirov, Nichola Jayne Starr, Mia Kvåle Løvmo, Sylvie Lelu, David J Scurr, Catharina de Lange Davies, Ruth B Schmid, Ýrr A Mørch
Protein adsorption on nanoparticles (NPs) used in nanomedicine leads to opsonization and activation of the complement system in blood, which substantially reduces the blood circulation time of NPs. The most commonly used method to avoid protein adsorption, is to coat the NPs with polyethylene glycol, so called PEGylation. Although PEGylation is of utmost importance for designing the in vivo behavior of the NP, there is still a considerable lack of methods for characterization and fundamental understanding related to the PEGylation of NPs...
February 7, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28168019/time-restricted-flight-ability-influences-dispersal-and-colonization-rates-in-a-group-of-freshwater-beetles
#4
Lars Lønsmann Iversen, Riinu Rannap, Lars Briggs, Kaj Sand-Jensen
Variation in the ability to fly or not is a key mechanism for differences in local species occurrences. It is increasingly acknowledged that physiological or behavioral mechanisms rather than morphological differences may drive flight abilities. However, our knowledge on the seasonal variability and stressors creating nonmorphological differences in flight abilities and how it scales to local and regional occurrences is very limited particularly for small, short-lived species such as insects. Here, we examine how flight ability might vary across seasons and between two closely related genera of freshwater beetles with similar geographical ranges, life histories, and dispersal-related morphology...
February 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28156608/when-home-means-another-nation-the-power-and-pitfalls-of-repatriation-at-the-end-of-life-from-a-tertiary-cancer-centre
#5
(no author information available yet)
: 46 Background: How people die lives on in the memory of those who survive. It is therefore pivotal for palliative teams to help craft an ending in line with patient and family goals. It has been observed in a tertiary cancer centre that there is often a spiritual imperative for patients to return to their nation of birth, once treatment is stopped and mortality accepted. METHODS: Retrospective chart review of 3 patients repatriated for end of life care to their nation of birth (Romania, Portugal, Ireland), focusing on: the conversations about the goal of repatriation and its meaning to the patient; the practical barriers and enablers of repatriation of patients with advanced cancer...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28153672/isoform-separation-and-structural-identification-of-mono-pegylated-recombinant-human-growth-hormone-peg-rhgh-with-ph-gradient-chromatography
#6
Xiufeng Qin, Jing Li, Yong Li, Yiru Gan, He Huang, Chenggang Liang
Human growth hormone plays an essential role in the treatment of dwarfism diseases, but it is limited in its short circulating half-life. Nowadays, some manufacturers are trying to take advantage of polyethylene glycol (PEG) conjugated with recombinant human growth hormone (rhGH) to improve its half-life and efficacy. However, the modified products are heterogeneous mixtures composed of reaction products with different modification sites. It is generally known as a challenging task to separate and characterize a PEGylated product, especially for its positional isoforms...
December 8, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28142195/aberrant-coordination-geometries-discovered-in-the-most-abundant-metalloproteins
#7
Sen Yao, Robert M Flight, Eric C Rouchka, Hunter N B Moseley
Metalloproteins bind and utilize metal ions for a variety of biological purposes. Due to the ubiquity of metalloprotein involvement throughout these processes across all domains of life, how proteins coordinate metal ions for different biochemical functions is of great relevance to understanding the implementation of these biological processes. Towards these ends, we have improved our methodology for structurally and functionally characterizing metal binding sites in metalloproteins. Our new ligand detection method is statistically much more robust, producing estimated false positive and false negative rates of ∼0...
January 31, 2017: Proteins
https://www.readbyqxmd.com/read/28132571/the-diagnosis-and-management-of-respiratory-viral-infections-in-cystic-fibrosis
#8
William Flight, Andrew Jones
Respiratory viruses, such as those that cause influenza and the common cold, are a regular feature of life for the entire human population. Among people with CF, these viruses are associated with prolonged respiratory illness and show a clear association with pulmonary exacerbations which in turn are associated with lung function decline and risk of death. Human rhinovirus is the most commonly encountered respiratory viral pathogen in CF although adenovirus, bocavirus, coronavirus, influenza, parainfluenza, metapneumovirus and respiratory syncytial virus are all also responsible for infections in this population...
February 3, 2017: Expert Review of Respiratory Medicine
https://www.readbyqxmd.com/read/28114403/proline-metabolism-is-essential-for-trypanosoma-brucei-brucei-survival-in-the-tsetse-vector
#9
Brian S Mantilla, Letícia Marchese, Aitor Casas-Sánchez, Naomi A Dyer, Nicholas Ejeh, Marc Biran, Frédéric Bringaud, Michael J Lehane, Alvaro Acosta-Serrano, Ariel M Silber
Adaptation to different nutritional environments is essential for life cycle completion by all Trypanosoma brucei sub-species. In the tsetse fly vector, L-proline is among the most abundant amino acids and is mainly used by the fly for lactation and to fuel flight muscle. The procyclic (insect) stage of T. b. brucei uses L-proline as its main carbon source, relying on an efficient catabolic pathway to convert it to glutamate, and then to succinate, acetate and alanine as the main secreted end products. Here we investigated the essentiality of an undisrupted proline catabolic pathway in T...
January 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28106519/subunit-mass-analysis-for-monitoring-antibody-oxidation
#10
Izabela Sokolowska, Jingjie Mo, Jia Dong, Michael J Lewis, Ping Hu
Methionine oxidation is a common posttranslational modification (PTM) of monoclonal antibodies (mAbs). Oxidation can reduce the in-vivo half-life, efficacy and stability of the product. Peptide mapping is commonly used to monitor the levels of oxidation, but this is a relatively time-consuming method. A high-throughput, automated subunit mass analysis method was developed to monitor antibody methionine oxidation. In this method, samples were treated with IdeS, EndoS and dithiothreitol to generate three individual IgG subunits (light chain, Fd' and single chain Fc)...
January 20, 2017: MAbs
https://www.readbyqxmd.com/read/28098892/metabolomics-study-on-primary-dysmenorrhea-patients-during-the-luteal-regression-stage-based-on-ultra-performance-liquid-chromatography-coupled-with-quadrupole%C3%A2-time%C3%A2-of%C3%A2-flight-mass-spectrometry
#11
Ling Fang, Caiyun Gu, Xinyu Liu, Jiabin Xie, Zhiguo Hou, Meng Tian, Jia Yin, Aizhu Li, Yubo Li
Primary dysmenorrhea (PD) is a common gynecological disorder which, while not life‑threatening, severely affects the quality of life of women. Most patients with PD suffer ovarian hormone imbalances caused by uterine contraction, which results in dysmenorrhea. PD patients may also suffer from increases in estrogen levels caused by increased levels of prostaglandin synthesis and release during luteal regression and early menstruation. Although PD pathogenesis has been previously reported on, these studies only examined the menstrual period and neglected the importance of the luteal regression stage...
January 13, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28095957/point-of-care-ultrasound-utility-and-potential-for-high-altitude-crew-recovery-missions
#12
Laura A Galdamez, Jonathan B Clark, Erik L Antonsen
INTRODUCTION: Flights to high altitude can lead to exposure and unique pathology not seen in normal commercial aviation. METHODS: This paper assesses the potential for point-of-care ultrasound to aid in management and disposition of injured crewmembers from a high altitude incident. This was accomplished through a systematic literature review regarding current diagnostic and therapeutic uses of ultrasound for injuries expected in high altitude free fall and parachuting...
February 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28094028/annual-10-month-aerial-life-phase-in-the-common-swift-apus-apus
#13
Anders Hedenström, Gabriel Norevik, Kajsa Warfvinge, Arne Andersson, Johan Bäckman, Susanne Åkesson
The common swift (Apus apus) is adapted to an aerial lifestyle, where food and nest material are captured in the air. Observations have prompted scientists to hypothesize that swifts stay airborne for their entire non-breeding period [1, 2], including migration into sub-Saharan Africa [3-5]. It is mainly juvenile common swifts that occasionally roost in trees or buildings before autumn migration when weather is bad [1, 6]. In contrast, the North American chimney swift (Chaetura pelagica) and Vaux's swift (C...
November 21, 2016: Current Biology: CB
https://www.readbyqxmd.com/read/28039424/seasonal-population-dynamics-of-megacopta-cribraria-hemiptera-plataspidae-in-kudzu-and-soybean-and-implication-for-insecticidal-management-in-soybean
#14
J L Blount, P M Roberts, M D Toews, W A Gardner, G D Buntin, J W Davis, J N All
Megacopta cribraria (F.), an invasive species introduced from Asia in 2009, is now prolific in the southeastern United States. Megacopta cribraria develops primarily on kudzu and soybean completing two generations. It is not well understood how this economic pest is affected by changes in geographic distribution in the United States or how population levels have changed since its establishment. The effect of insecticide application timing on field populations of M. cribraria is not well documented. These studies seek to understand how population dynamics of M...
December 29, 2016: Journal of Economic Entomology
https://www.readbyqxmd.com/read/28028548/spatial-molecular-architecture-of-the-microbial-community-of-a-peltigera-lichen
#15
Neha Garg, Yi Zeng, Anna Edlund, Alexey V Melnik, Laura M Sanchez, Hosein Mohimani, Alexey Gurevich, Vivian Miao, Stefan Schiffler, Yan Wei Lim, Tal Luzzatto-Knaan, Shengxin Cai, Forest Rohwer, Pavel A Pevzner, Robert H Cichewicz, Theodore Alexandrov, Pieter C Dorrestein
Microbes are commonly studied as individual species, but they exist as mixed assemblages in nature. At present, we know very little about the spatial organization of the molecules, including natural products that are produced within these microbial networks. Lichens represent a particularly specialized type of symbiotic microbial assemblage in which the component microorganisms exist together. These composite microbial assemblages are typically comprised of several types of microorganisms representing phylogenetically diverse life forms, including fungi, photosymbionts, bacteria, and other microbes...
November 2016: MSystems
https://www.readbyqxmd.com/read/28028082/a-variable-instar-climate-driven-individual-beetle-based-phenology-model-for-the-invasive-asian-longhorned-beetle-coleoptera-cerambycidae
#16
R Talbot Trotter, Melody A Keena
Efforts to manage and eradicate invasive species can benefit from an improved understanding of the physiology, biology, and behavior of the target species, and ongoing efforts to eradicate the Asian longhorned beetle (Anoplophora glabripennis Motschulsky) highlight the roles this information may play. Here, we present a climate-driven phenology model for A. glabripennis that provides simulated life-tables for populations of individual beetles under variable climatic conditions that takes into account the variable number of instars beetles may undergo as larvae...
December 2016: Environmental Entomology
https://www.readbyqxmd.com/read/28018664/altered-expression-of-pectoral-myosin-heavy-chain-isoforms-corresponds-to-migration-status-in-the-white-crowned-sparrow-zonotrichia-leucophrys-gambelii
#17
Brandy P Velten, Kenneth C Welch, Marilyn Ramenofsky
Birds undergo numerous changes as they progress through life-history stages, yet relatively few studies have examined how birds adapt to both the dynamic energetic and mechanical demands associated with such transitions. Myosin heavy chain (MyHC) expression, often linked with muscle fibre type, is strongly correlated with a muscle's mechanical power-generating capability, thus we examined several morphological properties, including MyHC expression of the pectoralis, in a long-distance migrant, the white-crowned sparrow (Zonotrichia leucophrys gambelii) throughout the progression from winter, spring departure and arrival on breeding grounds...
November 2016: Royal Society Open Science
https://www.readbyqxmd.com/read/28010844/pharmacokinetic-study-based-on-a-matrix-assisted-laser-desorption-ionization-quadrupole-ion-trap-time-of-flight-imaging-mass-microscope-combined-with-a-novel-relative-exposure-approach-a-case-of-octreotide-in-mouse-target-tissues
#18
Tai Rao, Yuhao Shao, Naoki Hamada, Yanmin Li, Hui Ye, Dian Kang, Boyu Shen, Xinuo Li, Xiaoxi Yin, Zhangpei Zhu, Haofeng Li, Lin Xie, Guangji Wang, Yan Liang
Application of imaging mass spectrometry in drug pharmacokinetics remains challenging due to its weak quantitative capability. Herein, an imaging mass microscope (iMScope), equipped with an optical microscope, an atmospheric pressure ion-source chamber for matrix-assisted laser desorption/ionization (AP-MALDI) and a hybrid quadrupole ion trap time-of-flight (QIT-TOF) analyzer, was first validated and applied to visualize drug disposition in vivo. The distribution and elimination rate of the therapeutic peptide octreotide, a long-acting analogue of the natural hormone somatostatin, was first calculated based on the data determined by iMScope system combining a novel relative exposure strategy...
February 1, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/27986943/flight-of-rhyzopertha-dominica-coleoptera-bostrichidae-a-spatio-temporal-analysis-with-pheromone-trapping-and-population-genetics
#19
A W Ridley, J P Hereward, G J Daglish, S Raghu, G A McCulloch, G H Walter
The flight of the lesser grain borer, Rhyzopertha dominica (F.), near grain storages and at distances from them, was investigated to assess the potential of these beetles to infest grain and spread insecticide resistance genes. We caught R. dominica in pheromone-baited flight traps (and blank controls) set at storages, in fields away from storages, and in native vegetation across a 12-mo period. A functional set of highly polymorphic microsatellite markers was developed, enabling population genetic analyses on the trapped beetles...
December 2016: Journal of Economic Entomology
https://www.readbyqxmd.com/read/27973609/laser-fluorescence-illuminates-the-soft-tissue-and-life-habits-of-the-early-cretaceous-bird-confuciusornis
#20
Amanda R Falk, Thomas G Kaye, Zhonghe Zhou, David A Burnham
In this paper we report the discovery of non-plumage soft tissues in Confuciusornis, a basal beaked bird from the Early Cretaceous Jehol Biota in northeastern China. Various soft tissues are visualized and interpreted through the use of laser-stimulated fluorescence, providing much novel anatomical information about this early bird, specifically reticulate scales covering the feet, and the well-developed and robust pro- and postpatagium. We also include a direct comparison between the forelimb soft tissues of Confuciusornis and modern avian patagia...
2016: PloS One
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