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https://www.readbyqxmd.com/read/28929788/the-familial-and-the-familiar-locating-relatedness-in-colombian-donor-conception
#1
Malissa Kay Shaw
In this article, I explore how women undergoing in-vitro fertilization with familial or anonymous egg donors located relatedness with a donor-conceived child through familial and social identities. Recognizing gametes as substances that contain biological and sociocultural/behavioral traits, shaped women's narratives around interconnected notions of the familial and familiar, or the social understanding of biological and social inheritance, and knowledge of the genetic materials involved. Women's narratives of relatedness reflect their relationships with family and society and their desire to reproduce these relationships in their child(ren), a process that reproduces prevailing Colombian social values and notions of ideal citizens...
September 20, 2017: Medical Anthropology
https://www.readbyqxmd.com/read/28923287/aberrant-expression-of-epithelial-leucine-rich-repeat-containing-g-protein-coupled-receptor-5-positive-cells-in-the-eutopic-endometrium-in-endometriosis-and-implications-in-deep-infiltrating-endometriosis
#2
Júlia Vallvé-Juanico, Elena Suárez-Salvador, Josep Castellví, Agustín Ballesteros, Hugh S Taylor, Antonio Gil-Moreno, Xavier Santamaria
OBJECTIVE: To characterize leucine-rich repeat containing G protein-coupled receptor 5-positive (LGR5(+)) cells from the endometrium of women with endometriosis. DESIGN: Prospective experimental study. SETTING: University hospital/fertility clinic. PATIENT(S): Twenty-seven women with endometriosis who underwent surgery and 12 healthy egg donors, together comprising 39 endometrial samples. INTERVENTION(S): Obtaining of uterine aspirates by using a Cornier Pipelle...
September 15, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28901845/a-review-of-patents-on-therapeutic-potential-and-delivery-of-hydrogen-sulfide
#3
Richa Verma, Yumna Akhtar, Somnath Singh
Hydrogen sulfide (H2S) is a colorless gas with a characteristic smell of rotten eggs. Once only thought of as a toxic gas, evidence now shows that H2S plays major roles in pathological and physiological activities. These roles are being utilized to treat diseases and disorders ranging from hypertension, inflammation, edema, cardiovascular issues, chronic pain, cancer, and many more. Challenges facing the use of H2S currently involve achieving the optimum therapeutic concentrations, synthesizing chemically and physiologically stable donors, and developing clinically appropriate delivery systems...
September 11, 2017: Recent Patents on Drug Delivery & Formulation
https://www.readbyqxmd.com/read/28889935/sociocultural-determinants-of-us-women-s-ethical-views-on-various-fertility-treatments
#4
Stephen C Collins, Esther Chan
Ethical concerns over treatments for infertility can discourage patients from pursuing fertility healthcare. This study aims to evaluate the sociocultural factors that influence the ethical views of reproductive-aged women regarding various fertility treatments. A publicly available cross-sectional survey of 4792 nationally representative US women aged 25-52 years was analysed to identify the frequency of ethical concerns over such interventions. Concerns were most common for treatments that increase the chance of twins (54%), followed by third-party reproductive strategies (48-51%), IVF (30%) and partner insemination (14%)...
August 25, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28822010/vitrification-of-human-immature-oocytes-before-and-after-in-vitro-maturation-a-review
#5
REVIEW
Mohammad Ali Khalili, Abbas Shahedi, Sareh Ashourzadeh, Stefania Annarita Nottola, Guido Macchiarelli, Maria Grazia Palmerini
The use of immature oocytes subjected to in vitro maturation (IVM) opens interesting perspectives for fertility preservation where ovarian reserves are damaged by pathologies or therapies, as in PCO/PCOS and cancer patients. Human oocyte cryopreservation may offer some advantages compared to embryo freezing, such as fertility preservation in women at risk of losing fertility due to oncological treatment or chronic disease, egg donation and postponing childbirth. It also eliminates religious and/or other ethical, legal, and moral concerns of embryo freezing...
August 18, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28815492/building-cre-knockin-rat-lines-using-crispr-cas9
#6
Yuanwu Ma, Lianfeng Zhang, Xingxu Huang
Conditional gene inactivation strategy helps researchers to study the gene functions that are critical in embryogenesis or in defined tissues of adulthood. The Cre/loxP system is widely used for conditional gene inactivation/activation in cells or organisms. Cre knockin animal lines are essential for gene expression or inactivation in a spatially and temporally restricted manner. However, to generate a Cre knockin line by traditional approach is laborious. Recently, the clustered regularly interspaced short palindromic repeats and CRISPR-associated protein 9 (CRISPR/Cas9) has been proven as a simple and efficient genome-editing tool...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28815355/egg-donation-of-vitrified-oocytes-bank-produces-similar-pregnancy-rates-by-blastocyst-transfer-when-compared-to-fresh-cycle
#7
Thais S Domingues, Ana Paula Aquino, Bruna Barros, Raquel Mazetto, Mariana Nicolielo, Carolina M Kimati, Talita Devecchi, Tatiana C S Bonetti, Paulo C Serafini, Eduardo L A Motta
PURPOSE: Advances in reproductive techniques, mainly the introduction of oocyte vitrification, have provided the opportunity to conceive from oocyte banks. The aim of this study was to compare the clinical outcomes of fresh and vitrified oocytes in an egg donation program following blastocyst transfer. METHODS: This retrospective observational study included 504 oocyte donation cycles. All donor women were younger than 30 years of age. The recipient cycles were divided into two groups: fresh oocytes (n = 78) or vitrified oocytes (n = 426)...
August 16, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28807295/anthelmintic-effects-of-forage-chicory-cichorium-intybus-against-free-living-and-parasitic-stages-of-cooperia-oncophora
#8
Miguel Peña-Espinoza, Andrew R Williams, Stig M Thamsborg, Henrik T Simonsen, Heidi L Enemark
Chicory shows great promise as an anthelmintic forage for grazing ruminants that can reduce reliance on anti-parasitic drugs. Recently, we reported potent anthelmintic effects of chicory-based diets in infected cattle with significant reductions in worm burdens of the abomasal nematode Ostertagia ostertagi, whilst no apparent activity was observed against the small intestinal parasite Cooperia oncophora. To explore this discrepancy, we investigated direct anthelmintic effects of forage chicory against C. oncophora in vitro...
August 30, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28783553/effect-of-advanced-maternal-age-on-maternal-and-neonatal-outcomes-in-assisted-reproductive-technology-pregnancies
#9
Amirhossein Moaddab, Frank A Chervenak, Laurence B Mccullough, Haleh Sangi-Haghpeykar, Amir A Shamshirsaz, Amy Schutt, Sara E Arian, Karin A Fox, Gary A Dildy, Alireza A Shamshirsaz
OBJECTIVES: To compare maternal and neonatal outcomes between women with assisted reproductive technologies pregnancy aged <40, 40-44, 45-49, and ≥50 years. STUDY: Design In a population-level analysis study, all live births by ART identified on birth certificate between 2011 and 2014 were extracted (n=101,494) using data from the Center for Disease Control and Prevention-National Center for Health Statistics (CDC-NCHS). We investigated and compared maternal and neonatal outcomes based on conditions routinely listed on birth certificates...
September 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28758779/a-longitudinal-study-of-families-formed-through-reproductive-donation-parent-adolescent-relationships-and-adolescent-adjustment-at-age-14
#10
Susan Golombok, Elena Ilioi, Lucy Blake, Gabriela Roman, Vasanti Jadva
The aim of the 6th phase of this longitudinal study was to establish whether children born through assisted reproduction involving reproductive donation were at risk for psychological problems following the transition to adolescence at age 14 and, if so, to examine the nature of these problems and the mechanisms involved. Eighty-seven families formed through reproductive donation, including 32 donor insemination families, 27 egg donation families, and 28 surrogacy families, were compared with 54 natural conception families...
July 31, 2017: Developmental Psychology
https://www.readbyqxmd.com/read/28757393/a-comparative-study-on-the-anti-schistosomal-and-hepatoprotective-effects-of-vinpocetine-and-isosorbide-5-mononitrate-on-schistosoma-mansoni-infected-mice
#11
Samar M Alhusseiny, Samar N El-Beshbishi, Maha M Abu Hashim, Hosam El-Dein E El-Nemr, Aya E Handoussa
Schistosomiasis is a remarkable public health problem in developing countries. Presently, praziquantel is the optional drug for all human schistosomiasis. Owing to the increased praziquantel resistance, there is an urgent need to develop new alternatives. This study aims at determining the anti-schistosomal and/or the hepatoprotective effects of the anti-inflammatory drug; vinpocetine, and the vasodilator and the nitric oxide donor; isosorbide-5-mononitrate, in comparison to praziquantel. In the present research, the therapeutic efficacies of these drugs were assessed in Swiss albino female mice (CD-I strain) experimentally infected with an Egyptian strain of Schistosoma mansoni, using some general, parasitological, and histopathological parameters...
July 27, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28751723/hydrogen-sulphide-donors-selectively-potentiate-a-green-tea-polyphenol-egcg-induced-apoptosis-of-multiple-myeloma-cells
#12
Jaehoon Bae, Motofumi Kumazoe, Shuya Yamashita, Hirofumi Tachibana
Hydrogen sulphide (H2S) is a colourless gas with the odour of rotten eggs and has recently been recognized as a signal mediator in physiological activities related with the regulation of homeostasis, the vascular system and the inflammatory system. Here we show that H2S donors, including sodium hydrogen sulphide (NaHS), GYY 4137 and diallyltrisulfide (DATS), synergistically enhanced the anti-cancer effect of a green tea polyphenol (-)-epigallocatechin-3-O-gallate (EGCG) against multiple myeloma cells without affecting normal cells...
July 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28747071/a-hibernation-like-state-for-transplantable-organs-is-h-sub-2-sub-s-therapy-the-future-of-organ-preservation
#13
George Dugbartey, Hjalmar Bouma, Manujendra N Saha, Ian Lobb, Robert H Henning, Alp Sener
Renal transplantation is the treatment of choice for end-stage renal disease, during which renal grafts from deceased donors are routinely cold stored to suppress metabolic demand and thereby limit ischemic injury. However, prolonged cold storage followed by reperfusion induces extensive tissue damage termed cold ischemia/reperfusion injury (IRI) and puts the graft at risk of both early and late rejection. The underlying mechanism of IRI is not completely understood and a reliable/ suitable method to protect the renal graft against cold IRI is lacking...
July 26, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28740754/the-time-course-of-broiler-intestinal-microbiota-development-after-administration-of-cecal-contents-to-incubating-eggs
#14
Erin E Donaldson, Dragana Stanley, Robert J Hughes, Robert J Moore
BACKGROUND: The microbial populations that inhabit the gastrointestinal tract (GIT) are known to influence the health and growth performance of the host. Clean hatcheries and machine-based incubation practices in the commercial poultry industry can lead to the acquisition of aberrant microbiota in the GIT of chickens and a very high level of bird-to-bird variation. The lack of microbial profile flock uniformity presents challenges for harnessing and manipulating intestinal bacteria to better serve the host...
2017: PeerJ
https://www.readbyqxmd.com/read/28721183/infertility-in-the-global-south-raising-awareness-and-generating-insights-for-policy-and-practice
#15
T Gerrits, F Van Rooij, T Esho, W Ndegwa, J Goossens, A Bilajbegovic, A Jansen, B Kioko, L Koppen, S Kemunto Migiro, S Mwenda, H Bos
Infertility is a highly prevalent reproductive health condition in the global South, which often has a devastating impact on the people concerned. Yet, thus far it hardly received any attention from policy makers, Non-Governmental Organizations (NGOs) or donors working in the field of Sexual and Reproductive Health and Rights (SRHR). For this reason we have set up a project to increase knowledge and awareness about infertility and childlessness among those stakeholders and organizations and to generate insight into (possible) interventions in this field...
March 2017: Facts, Views & Vision in ObGyn
https://www.readbyqxmd.com/read/28708521/flow-cytometric-enrichment-of-pacific-bluefin-tuna-type-a-spermatogonia-based-on-light-scattering-properties
#16
REVIEW
Kensuke Ichida, Kazuyoshi Kise, Tetsuro Morita, Ryosuke Yazawa, Yutaka Takeuchi, Goro Yoshizaki
We previously established surrogate broodstock in which the donor germ cells transplanted into the peritoneal cavities of xenogeneic recipients were capable of developing into functional eggs and sperm in teleost fish. In this transplantation system, only the undifferentiated germ cells such as type A spermatogonia (ASG) or a portion of the ASG population were capable of being incorporated into the genital ridges of the recipients and undergo gametogenesis. Therefore, the use of enriched ASGs can be expected to achieve efficient donor-cell incorporation...
June 22, 2017: Theriogenology
https://www.readbyqxmd.com/read/28697908/sperm-donor-conception-and-disclosure-to-children-a-10-year-retrospective-follow-up-study-of-parental-attitudes-in-one-french-center-for-the-study-and-preservation-of-eggs-and-sperm-cecos
#17
Thierry Lassalzede, Marine Paci, Jocelyne Rouzier, Sophie Carez, Audrey Gnisci, Jacqueline Saias-Magnan, Carole Deveze, Jeanne Perrin, Catherine Metzler-Guillemain
OBJECTIVE: To evaluate the percentage of parents in one French center for the study and preservation of eggs and sperm who disclose their use of donated spermatozoa to their children. DESIGN: A questionnaire survey of couples who had a child using donated spermatozoa. SETTING: University hospital laboratory. PATIENT(S): One hundred five couples. INTERVENTION(S): Questionnaire sent by mail. MAIN OUTCOME MEASURE(S): The percentage of parents who disclose their use of donated spermatozoa to their child...
August 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28697393/same-medicine-different-reasons-comparing-women-s-bodily-experiences-of-producing-eggs-for-pregnancy-or-for-profit
#18
Rene Almeling, Iris L Willey
Women doing in vitro fertilization (IVF) to have a child describe it as painful and emotionally draining. Egg donors undergo the same medical regimen for a different reason - to produce eggs for another woman in exchange for thousands of dollars - and describe it as quick and relatively painless. Medical researchers typically compare bodily responses by variables such as gender, age, and health status. We use the case of "egg production" to propose a new factor that may be an important source of variation in bodily experience: an individual's reason for undergoing the medical intervention in the first place...
June 22, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28686488/contribution-of-both-b-cell-intrinsic-alterations-as-well-as-non-hematopoietic-derived-factors-in-the-enhanced-immune-response-of-the-nod-mouse
#19
Viqar Showkat Banday, Radha Thyagarajan, Kristina Lejon
The underlying cellular and molecular mechanism for the development of Type 1 diabetes is still to be fully revealed. We have previously demonstrated that the NOD mouse, a model for Type 1 diabetes, display a prolonged and enhanced immune response to both self and non-self-antigens. The molecular explanation for this defect however, has not been determined. In this study we immunized NOD and C57BL/6 (B6) with the conventional antigen i.e. hen egg lysozyme (HEL) and analyzed B cell activation, germinal center reaction and antibody clearance...
July 7, 2017: Autoimmunity
https://www.readbyqxmd.com/read/28683668/kinship-identities-in-the-context-of-uk-maternal-spindle-transfer-and-pronuclear-transfer-legislation
#20
Calum MacKellar
In the discussions leading up to the enactment of the UK Human Fertilisation and Embryology (Mitochondrial Donation) Regulations 2015, it was repeatedly emphasised, by many commentators, that maternal spindle transfer (MST) and pronuclear transfer (PNT) did not give rise to children who could be considered as having three or more parents. This was because it was argued that only the genetic material found in the chromosomes should be considered as the determining factor for the formation of parent-child relationships and the resulting kinship identities...
July 6, 2017: New Bioethics: a Multidisciplinary Journal of Biotechnology and the Body
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