keyword
https://read.qxmd.com/read/38532526/paternal-aging-impacts-expression-and-epigenetic-markers-as-early-as-the-first-embryonic-tissue-lineage-differentiation
#1
JOURNAL ARTICLE
Michelle M Denomme, Blair R McCallie, Mary E Haywood, Jason C Parks, William B Schoolcraft, Mandy G Katz-Jaffe
BACKGROUND: Advanced paternal age (APA) is associated with adverse outcomes to offspring health, including increased risk for neurodevelopmental disorders. The aim of this study was to investigate the methylome and transcriptome of the first two early embryonic tissue lineages, the inner cell mass (ICM) and the trophectoderm (TE), from human blastocysts in association with paternal age and disease risk. High quality human blastocysts were donated with patient consent from donor oocyte IVF cycles from either APA (≥ 50 years) or young fathers...
March 26, 2024: Human Genomics
https://read.qxmd.com/read/38531673/natural-proliferative-phase-frozen-embryo-transfer-a-new-approach-which-may-facilitate-scheduling-without-hindering-pregnancy-outcomes
#2
JOURNAL ARTICLE
Catarina Mendes Godinho, Sérgio Reis Soares, Sofia Gouveia Nunes, Juan M Mascarós Martínez, Samuel Santos-Ribeiro
STUDY QUESTION: How does a natural proliferative phase (NPP) strategy for frozen embryo transfer (FET) compare with the conventional artificial (AC) and natural (NC) endometrial preparation protocols in terms of live birth rates (LBR)? SUMMARY ANSWER: This study supports the hypothesis that, just as for NC, NPP-FET may be a superior alternative to AC in terms of LBR. WHAT IS KNOWN ALREADY: Although FETs are increasing worldwide, the optimal FET protocol is still largely controversial...
March 26, 2024: Human Reproduction
https://read.qxmd.com/read/38520618/obstetric-and-maternal-outcomes-of-ivf-and-oocyte-donation-pregnancies-among-women-ages-40-45-a-large-cohort-study
#3
JOURNAL ARTICLE
Roni Rahav-Koren, Hila Shalev-Ram, Einat Haikin-Herzberger, Mattan Levi, Amir Wiser, Netanella Miller
PURPOSE: To analyze the perinatal and maternal outcomes of women ranging in age from 40 to 45 years who gave birth after in vitro fertilization or oocyte donation, compared to spontaneous conception. METHODS: This retrospective cohort study used electronic data from a national healthcare service from 2000 through 2019. Three groups were compared: spontaneous pregnancy (SC), in vitro fertilization (IVF) utilizing autologous oocytes, and pregnancies resulting from oocyte donation (OD)...
March 23, 2024: Journal of Assisted Reproduction and Genetics
https://read.qxmd.com/read/38470726/oxidative-stress-and-acrosomal-status-of-human-spermatozoa-subjected-to-hydrophobic-carbon-soot-treatments
#4
JOURNAL ARTICLE
Karekin D Esmeryan, Ivaylo Rangelov, Todor A Chaushev
The fourth industrial revolution extensively reshapes the reality we are living in by blurring the boundaries of physical, digital and biological worlds. A good example is the previously unthinkable incursion of nanoscale waste materials, such as soot, into the technologies for assisted reproduction. Although the rapeseed oil soot may efficiently enhance the progressive motility of human spermatozoa, it is yet unknown whether this material induces undesirable oxidative stress and premature acrosome reaction, endangering the sperm-oocyte fusion and blastocyst formation...
February 21, 2024: Nanomaterials
https://read.qxmd.com/read/38458058/progestin-primed-ovarian-stimulation-using-dydrogesterone-from-day-7-of-the-cycle-onwards-in-oocyte-donation-cycles-a-longitudinal-study
#5
JOURNAL ARTICLE
S Hendrickx, M De Vos, N De Munck, S Mackens, S Ruttens, H Tournaye, C Blockeel
RESEARCH QUESTION: Does a progestin-primed ovarian stimulation (PPOS) protocol with dydrogesterone from cycle day 7 yield similar outcomes compared with a gonadotrophin-releasing hormone (GnRH) antagonist protocol in the same oocyte donors? DESIGN: This retrospective longitudinal study included 128 cycles from 64 oocyte donors. All oocyte donors had the same type of gonadotrophin and daily dose in both stimulation cycles. The primary outcome was the number of cumulus-oocyte complexes (COC) retrieved...
November 20, 2023: Reproductive Biomedicine Online
https://read.qxmd.com/read/38452347/navigating-fertility-dilemmas-across-the-lifespan-in-girls-with-turner-syndrome-a-scoping-review
#6
JOURNAL ARTICLE
Sanne van der Coelen, Janielle van der Velden, Sapthami Nadesapillai, Didi Braat, Ronald Peek, Kathrin Fleischer
BACKGROUND: Girls with Turner syndrome (TS) lack a partial or complete sex chromosome, which causes an accelerated decline of their ovarian reserve. Girls have to deal with several dilemmas related to their fertility, while only a limited number of them are referred to a fertility specialist and counselled about options of family planning on time. OBJECTIVE AND RATIONALE: This scoping review provides an update of the literature on fertility in girls with TS throughout their lifespan and aims to propose a clinical practice guideline on fertility in TS...
March 7, 2024: Human Reproduction Update
https://read.qxmd.com/read/38420661/what-importance-do-donors-and-recipients-attribute-to-the-nuclear-dna-related-genetic-heritage-of-oocyte-donation
#7
JOURNAL ARTICLE
A Mayeur, F Magnan, S Mathieu, P Rubens, B Sperelakis Beedham, C Sonigo, J Steffann, N Frydman
STUDY QUESTION: How do oocyte donors and recipients perceive the genetic link related to the transfer of nuclear DNA between donors and offspring? SUMMARY ANSWER: Whether they are donors or recipients, individuals attach great importance to the transmission of their genetic heritage, since 94.5% would opt for the pronuclear transfer method to preserve this genetic link in the context of oocyte donation. WHAT IS KNOWN ALREADY: Since 1983, the use of oocyte donation has increased worldwide...
February 28, 2024: Human Reproduction
https://read.qxmd.com/read/38397479/current-status-and-future-prospects-of-stem-cell-therapy-for-infertile-patients-with-premature-ovarian-insufficiency
#8
REVIEW
Hye Kyeong Kim, Tae Jin Kim
Premature ovarian insufficiency (POI), also known as premature menopause or premature ovarian failure, signifies the partial or complete loss of ovarian endocrine function and fertility before 40 years of age. This condition affects approximately 1% of women of childbearing age. Although 5-10% of patients may conceive naturally, conventional infertility treatments, including assisted reproductive technology, often prove ineffective for the majority. For infertile patients with POI, oocyte donation or adoption exist, although a prevalent desire persists among them to have biological children...
February 19, 2024: Biomolecules
https://read.qxmd.com/read/38373211/psychosocial-outcomes-of-children-born-via-embryo-donation
#9
JOURNAL ARTICLE
Salomeh Salari, Seungho Lee, Joshua Mangels, Rebecca Flyckt, Jody Madeira, John Gordon, Jeffrey Keenan, Miryoung Lee, Paul Lin, Guido Pennings, Craig Sweet, Susan Klock, Steven R Lindheim
STUDY QUESTION: What are parents' perceptions of their relationships with and the psychosocial adjustments of their children who are born via embryo donation? SUMMARY ANSWER: Families created through embryo donation have well-adjusted parent-child relationships and reassuring child psychosocial outcomes. WHAT IS KNOWN ALREADY: Embryo donation is an effective and growing form of third-party reproduction, but there is limited research in this field...
February 19, 2024: Human Reproduction
https://read.qxmd.com/read/38371224/neurotrophin-4-promotes-in-vitro-development-and-maturation-of-human-secondary-follicles-yielding-metaphase-ii-oocytes-and-successful-blastocyst-formation
#10
JOURNAL ARTICLE
Yingchun Guo, Lei Jia, Haitao Zeng, Peng Sun, Wenlong Su, Tingting Li, Xiaoyan Liang, Cong Fang
STUDY QUESTION: Does a matrix-free culture system supplemented with neurotrophic factor 4 (NT4) improve human in vitro follicular development and meiotic maturation, ultimately resulting in fertilizable oocytes? SUMMARY ANSWER: NT4 supplementation of in vitro culture significantly enhances the growth, steroid hormone production, and maturity potential of human secondary follicles derived from fresh ovarian medulla (from post- and pre-pubertal patients), thereby yielding fertilizable oocytes...
2024: Human Reproduction Open
https://read.qxmd.com/read/38330858/storage-trends-usage-and-disposition-outcomes-following-egg-freezing
#11
JOURNAL ARTICLE
Molly Johnston, Giuliana Fuscaldo, Elizabeth Sutton, Sarah Hunt, Deirdre Zander-Fox, Luk Rombauts, Catherine Mills
RESEARCH QUESTION: What happens to eggs after egg freezing? DESIGN: A retrospective cohort study was performed spanning 2012-2022. Data were obtained from seven assisted reproductive technology clinics in Victoria, Australia. Aggregated, de-identified data were collected on cycles that resulted in egg freezing and the following outcomes, including treatment involving thawed eggs and disposition outcomes of surplus eggs. RESULTS: The number of patients with eggs in storage grew rapidly from 144 in 2012 to 2015 in 2022...
November 16, 2023: Reproductive Biomedicine Online
https://read.qxmd.com/read/38323956/family-members-as-gamete-donors-or-gestational-carriers-an-ethics-committee-opinion
#12
JOURNAL ARTICLE
(no author information available yet)
The use of adult intrafamilial gamete donors and gestational surrogates is generally ethically acceptable when all participants are fully informed and counseled, but consanguineous arrangements or ones that simulate incestuous unions should be prohibited. Adult child-to-parent arrangements require caution to avoid coercion, and parent-to-adult child arrangements are acceptable in limited situations. Programs that choose to participate in intrafamilial arrangements should be prepared to spend additional time counseling participants and ensuring that they have made free, informed decisions...
February 6, 2024: Fertility and Sterility
https://read.qxmd.com/read/38323618/preimplantation-genetic-testing-as-a-preventive-strategy-for-the-transmission-of-mitochondrial-dna-disorders
#13
REVIEW
Xinpeng Lan, Wu Liji Ao, Ji Li
Mitochondrial diseases are distinct types of metabolic and/or neurologic abnormalities that occur as a consequence of dysfunction in oxidative phosphorylation, affecting several systems in the body. There is no effective treatment modality for mitochondrial disorders so far, emphasizing the clinical significance of preventing the inheritance of these disorders. Various reproductive options are available to reduce the probability of inheriting mitochondrial disorders, including in vitro fertilization (IVF) using donated oocytes, preimplantation genetic testing (PGT), and prenatal diagnosis (PND), among which PGT not only makes it possible for families to have genetically-owned children but also PGT has the advantage that couples do not have to decide to terminate the pregnancy if a mutation is detected in the fetus...
December 2024: Systems Biology in Reproductive Medicine
https://read.qxmd.com/read/38301263/addressing-privacy-concerns-surrounding-oocyte-donation-in-the-united-states-gone-with-anonymity
#14
REVIEW
Shelun Tsai, Jennifer L Eaton
Oocyte donation has greatly expanded in the past several decades since the first procedure was performed in 1983. According to the Centers for Disease Control, the number of cycles using donor oocytes increased from 18,011 cycles in 2010 to 27,131 cycles in 2019. Oocyte donation has become an important reproductive option for women with diminished ovarian reserve, recurrent failed in vitro fertilization, or heritable genetic conditions. It is also particularly important for single men, same-sex male couples, and men with a transgender woman partner...
April 1, 2024: Obstetrics and Gynecology
https://read.qxmd.com/read/38298815/pregnancies-through-oocyte-donation-a-mini-review-of-pathways-involved-in-placental-dysfunction
#15
REVIEW
Javier Caradeux, Benjamín Fernández, Francisco Ávila, Andrés Valenzuela, Mauricio Mondión, Francesc Figueras
Pregnancies resulting from assisted reproductive techniques (ART) are increasingly prevalent worldwide. While most pregnancies conceived through in-vitro fertilization (IVF) progress without complications, mounting evidence suggests that these pregnancies are at a heightened risk of adverse perinatal outcomes. Specifically, IVF pregnancies involving oocyte donation have garnered attention due to numerous reports indicating an elevated risk profile for pregnancy-related complications within this subgroup of patients...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38294811/live-birth-after-oocyte-donation-in-vitro-fertilization-cycles-in-women-with-endometriosis-a-systematic-review-and-meta-analysis
#16
JOURNAL ARTICLE
Alessio Paffoni, Maíra Casalechi, Dominique De Ziegler, Ettore Cicinelli, Edgardo Somigliana, Paola Viganò, Amerigo Vitagliano
IMPORTANCE: Although multiple mechanisms have been proposed to explain the infertility related to endometriosis, there are no conclusive data on the association of endometriosis with endometrial receptivity. The oocyte donation model in assisted reproduction technology (ART) cycles can clarify this issue. OBJECTIVE: To explore the association of a history of endometriosis with ART outcomes in recipients of oocyte donation. DATA SOURCES: In this systematic review and meta-analysis, electronic databases were searched from inception until August 31, 2023, using combinations of relevant keywords...
January 2, 2024: JAMA Network Open
https://read.qxmd.com/read/38283774/management-of-recurrent-implantation-failure-and-hereditary-thrombophilia-a-case-report
#17
Tamar Barbakadze, Tengiz Zhorzholadze, Nino Kutchukhidze, Mariam Shervashidze, Tea Charkviani
Recurrent implantation failure (RIF) is one of the core problems for assisted reproductive technology (ART). High-quality, euploid embryos and synchronization between the embryonic stage and the uterine endometrial lining are crucial for positive outcomes. Molecular biology techniques have significantly transformed assisted reproductive technology (ART). Numerous couples facing infertility issues have successfully achieved the birth of healthy infants through the application of molecular biology methods: preimplantation genetic testing for aneuploidy (PGT-A) and endometrial receptivity analysis (ERA)...
January 2024: Curēus
https://read.qxmd.com/read/38268234/the-intrafollicular-concentrations-of-biologically-active-cortisol-in-women-rise-abruptly-shortly-before-ovulation-and-follicular-rupture
#18
JOURNAL ARTICLE
M L Johannsen, L C Poulsen, L S Mamsen, M L Grøndahl, A L M Englund, N L Lauritsen, E C Carstensen, B Styrishave, C Yding Andersen
STUDY QUESTION: What is the temporal activity and the concentration in follicular fluid (FF) of the anti-inflammatory steroid cortisol during the ovulatory process in humans? SUMMARY ANSWER: Intrafollicular concentrations of cortisol become massively upregulated close to ovulation concomitant with an exceptionally high biological activity securing a timely and efficient termination of inflammatory processes. WHAT IS KNOWN ALREADY: Ovulation has been described as a local, controlled inflammatory process resulting in the degeneration of the follicle wall which facilitate oocyte extrusion...
January 24, 2024: Human Reproduction
https://read.qxmd.com/read/38266482/no-association-between-lh-levels-and-ovarian-response-in-oocyte-donors-triggered-with-gonadotropin-releasing-hormone-agonist-a-prospective-study
#19
JOURNAL ARTICLE
Anna Blazquez, Noelia Falcó, Elena Caño, Flavia Rodriguez, Rita Vassena, Irene Miguel-Escalada, Mina Popovic, Amelia Rodriguez
OBJECTIVE: Are circulating luteinizing hormone (LH) levels predictive of ovarian response in oocyte donors triggered with gonadotropin-releasing hormone (GnRH) agonists? STUDY DESIGN: A prospective cohort study with 224 oocyte donation cycles between 2021 and 2022 at a single center, examined the relationship between circulating luteinizing hormone (LH) levels and ovarian response. Oocyte donors underwent GnRH antagonist downregulation followed by GnRH agonist trigger...
March 2024: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://read.qxmd.com/read/38261363/should-a-gamete-bank-verify-the-non-medical-information-provided-by-a-donor
#20
JOURNAL ARTICLE
Guido Pennings
Over the years, cases of fraud have been discovered where donors have been lying about their characteristics. The question raised by such cases is what the responsibility of the gamete bank is for the non-medical information provided by the donor. The problem is that extended donor profiles contain a large amount of information about different aspects of the donor's life and that not all this information can be verified or is worth verifying. Two cases are scrutinized in more detail: education and criminal record...
January 22, 2024: Human Reproduction
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