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Oocyte donation

Evangelia Elenis, Gunilla Sydsjö, Alkistis Skalkidou, Claudia Lampic, Agneta Skoog Svanberg
BACKGROUND: Pregnancies resulting through oocyte donation have been associated with increased risk for adverse outcomes for the mother, such as gestational hypertensive disorders. However, little is known about possible neonatal complications of such pregnancies. The purpose of this study was to evaluate the neonatal health outcomes among singleton pregnancies in a population of relatively young and healthy oocyte recipients in Sweden, taking into account the medical indication leading to treatment...
October 21, 2016: BMC Pediatrics
Yuki Ito, Eriko Shiraishi, Atsuko Kato, Takayuki Haino, Kouhei Sugimoto, Aikou Okamoto, Nao Suzuki
PURPOSE: To identify the utility and issues associated with the use of decision trees in oncofertility patient care in Japan. METHODS: A total of 35 women who had been diagnosed with cancer, but had not begun anticancer treatment, were enrolled. We applied the oncofertility decision tree for women published by Gardino et al. to counsel a consecutive series of women on fertility preservation (FP) options following cancer diagnosis. Percentage of women who decided to undergo oocyte retrieval for embryo cryopreservation and the expected live-birth rate for these patients were calculated using the following equation: expected live-birth rate = pregnancy rate at each age per embryo transfer × (1 - miscarriage rate) × No...
October 20, 2016: Journal of Adolescent and Young Adult Oncology
Elodie Guesdon, Aurélie Vincent-Rohfritsch, Sarah Bydlowski, Pietro Santulli, François Goffinet, Camille Le Ray
OBJECTIVE: To compare maternal, obstetric, and neonatal outcomes between women who underwent oocyte donation at or after age 50 years and from 45 through 49 years. DESIGN: Single-center, retrospective cohort study. SETTING: Maternity hospital. PATIENT(S): Forty women aged 50 years and older ("older group") and 146 aged 45-49 years ("younger group"). INTERVENTION(S): Comparison between the older and younger groups, globally and after stratification by type of pregnancy (singleton/twin pregnancy)...
October 12, 2016: Fertility and Sterility
Sylvie Jaillard, Linda Akloul, Marion Beaumont, Houda Hamdi-Roze, Christele Dubourg, Sylvie Odent, Solène Duros, Nathalie Dejucq-Rainsford, Marc-Antoine Belaud-Rotureau, Célia Ravel
BACKGROUND: Ovarian failure (OF) is considered premature if it occurs before the age of 40. This study investigates the genetic aetiology underlying OF in women under the age of 40 years. METHODS: We conducted an experimental prospective study performing all genome microarrays in 60 patients younger than 40 years presenting an OF revealed by a decrease of circulating Anti-Müllerian Hormone (AMH) and leading to an oocyte donation program. RESULTS: We identified nine significant copy number variations (CNVs) including candidate genes potentially implicated in reproductive function...
October 3, 2016: Journal of Ovarian Research
Joseph Hasson, Togas Tulandi, Weon-Yong Son, Na'ama Al Ma'mari, Ahmad Badeghiesh, Sammer Tannus, Janet Takefman, Tal Shavit
OBJECTIVE: Oocyte donation (OD) from a family member may be more available to patients. Our objective was to compare reproductive outcomes of familial OD with those of unrelated OD. DESIGN: Retrospective cohort study in a single university-affiliated center. SETTING: Not applicable. PATIENT(S): Four hundred thirty OD cycles performed from 2010 to 2014: 124 from family members and 306 from unrelated donors. INTERVENTION(S): None...
September 24, 2016: Fertility and Sterility
Vitaly A Kushnir, Norbert Gleicher
PURPOSE OF REVIEW: Utilization of cryopreserved instead of fresh donor oocytes has rapidly increased in recent years. Whether treatment outcomes are comparable has, however, remained controversial. RECENT FINDINGS: More than 24% of initiated oocyte donation cycles in the USA during 2013-2014 involved previously cryopreserved oocytes. The use of cryopreserved-donated oocytes may simplify logistics and lower costs per treatment cycle. Whether cryopreserved donor oocytes also lower costs per live birth is still undetermined as they result in lower live birth rates in comparison to fresh donor oocyte cycles...
September 24, 2016: Current Opinion in Endocrinology, Diabetes, and Obesity
T T F Huang, K Chinn, T Kosasa, H J Ahn, B Kessel
Time-lapse imaging offers new tools to study dynamic processes of development such as blastocyst formation and expansion. This study quantitatively describes expansion in human blastocysts from donated oocytes. Measurements of hourly interval rate of changes in the blastocoel cross-sectional area revealed oscillatory pulses having 2-4 h periodicities. Two types of oscillations were distinguished. An E-Type ('expansion') had positive peak and positive or slightly negative trough interval rate of change values, and these characterized most of the expansion period...
September 12, 2016: Reproductive Biomedicine Online
Pierre-Emmanuel Bouet, Ariane Godbout, Hady El Hachem, Maude Lefebvre, Lyne Bérubé, Marie-Danielle Dionne, Carole Kamga-Ngande, Louise Lapensée
Turner syndrome (TS) occurs in one in 2500 live female births and is one of the most common chromosomal abnormalities in women. Pregnancies in women with TS, conceived with either autologous or donated oocytes, are considered high risk because of the associated miscarriages and life-threatening cardiovascular complications (aortic dissection, severe hypertension). Therefore, it is imperative to conduct a full preconception evaluation and counselling that includes cardiac assessment with Holter blood pressure monitoring, echocardiography, and thoracic MRI...
August 2016: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
E Warzych, P Pawlak, M Pszczola, A Cieslak, D Lechniak
The oocyte quality is to a large extent influenced by the sexual maturity of the donor female. Although this phenomenon has already been broadly described in domestic animals, the underlying mechanisms are poorly understood. Published data focus on oocyte ultrastructure, fertilization abnormalities, and blastocyst developmental rate. The goal of the present experiment was to characterize the follicular environment (oocyte, cumulus [CC] and granulosa (GC) cells as well as follicular fluid [FF]) in ovarian follicles of prepubertal heifers and cows...
August 12, 2016: Theriogenology
A Blázquez, D García, A Rodríguez, R Vassena, V Vernaeve
STUDY QUESTION: Does switching to donor semen after at least three failed oocyte donation (OD) cycles with the partner normozoospermic semen increase the live birth rate in a subsequent OD cycle? SUMMARY ANSWER: Switching to donor semen after at least three failed OD cycles with the partner normozoospermic semen does not increase the live birth rate. WHAT IS ALREADY KNOWN: In some patients, a viable pregnancy cannot be achieved after several OD cycles, despite normal diagnostic findings for the couple...
September 8, 2016: Human Reproduction
M Storgaard, A Loft, C Bergh, U B Wennerholm, V Söderström-Anttila, L B Romundstad, K Aittomaki, N Oldereid, J Forman, A Pinborg
BACKGROUND: Approximately 50 000 oocyte donation (OD) treatment cycles are now performed annually in Europe and the US. OBJECTIVES: To ascertain whether the risk of adverse obstetric and perinatal/neonatal outcomes is higher in pregnancies conceived by OD than in pregnancies conceived by conventional in-vitro fertilisation (IVF)/intracytoplasmic sperm injection (ICSI) or spontaneously. SEARCH STRATEGY: A systematic search was performed in the PubMed, Cochrane and Embase databases from 1982-2016...
September 5, 2016: BJOG: An International Journal of Obstetrics and Gynaecology
Iris M van Hagen, Anthonie L Duijnhouwer, Marianne J Ten Kate-Booij, Ramon H M Dykgraaf, Johannes J Duvekot, Elisabeth M W J Utens, Jolien W Roos-Hesselink
INTRODUCTION: Turner syndrome (TS) is associated with subfertility and infertility. Nevertheless, an increasing number of women become pregnant through oocyte donation. The wish to conceive may be negatively influenced by the fear of cardiovascular complications. The aim was to investigate the wish to conceive and the concerns about cardiovascular complications during pregnancy in women with TS. METHODS: The patient association for TS invited all members of ≥18 years old (n = 344) to complete a specifically developed, disease-specific questionnaire, including questions about fertility, wish to conceive, attempts and concerns...
September 1, 2016: Journal of Psychosomatic Obstetrics and Gynaecology
Ruth Morales, Belén Lledó, José A Ortiz, Jorge Ten, Joaquin Llácer, Rafael Bernabeu
UNLABELLED: Chromosomal polymorphisms involve heterochromatic regions and occur in the general population. However, previous studies have reported a higher incidence of these variants in infertile patients. The aim of this study was to examine the relationship between polymorphic variants and infertility and their association with aneuploidies in male gametes and embryos. We retrospectively considered 1,551 cytogenetic studies involving infertile patients (study group; n=866) and oocyte/sperm donors as the control group (n=685)...
October 2016: Systems Biology in Reproductive Medicine
P A De Sousa, B J Tye, K Bruce, P Dand, G Russell, D M Collins, A Greenshields, K McDonald, H Bradburn, M A Canham, T Kunath, J M Downie, M Bateman, A Courtney
The human embryonic stem cell line RCe013-A (RC-9) was derived under quality assured compliance with UK regulation, European Union Directives and International guidance for tissue procurement, processing and storage according to Good Manufacturing Practice (GMP) standards. The cell line was derived from a failed to fertilise oocyte voluntarily donated as unsuitable and surplus to fertility requirements following informed consent. RCe013-A (RC-9) shows normal pluripotency marker expression and differentiation to the three germ layers in vitro and in vivo...
May 6, 2016: Stem Cell Research
Belén Aparicio-Ruiz, Natalia Basile, Sonia Pérez Albalá, Fernando Bronet, José Remohí, Marcos Meseguer
OBJECTIVE: To correlate the different categories provided by a commercial diagnostic test with blastocyst formation, quality, implantation potential, and ongoing pregnancy (OPR) for the purpose of validating the automatic annotations and the classification algorithm. DESIGN: Observational, retrospective, multicenter cohort study. SETTING: University-affiliated private IVF center. PATIENT(S): A total of 3,002 embryos, including 521 transferred embryos with known implantation, from 626 IVF cycles that were incubated in a conventional incubator and monitored with an automatic time-lapse test...
August 13, 2016: Fertility and Sterility
(no author information available yet)
This opinion addresses the ethics of providing fertility treatment to women at elevated risk from fertility treatment or pregnancy. Providers ethically may treat women at elevated risk provided that they are carefully assessed; that specialists in their medical condition are consulted as appropriate; and that patients are fully informed about risks, benefits, and alternatives, including oocyte and embryo donation, use of a gestational surrogate, not undergoing fertility care, and adoption. Providers also may conclude that the risks are too high for them to ethically treat particular patients; such determinations must be made in a medically objective and unbiased manner and patients must be fully informed of the decision...
August 13, 2016: Fertility and Sterility
C Calhaz-Jorge, C de Geyter, M S Kupka, J de Mouzon, K Erb, E Mocanu, T Motrenko, G Scaravelli, C Wyns, V Goossens
STUDY QUESTION: The 16th European IVF-monitoring (EIM) report presents the data of the treatments involving assisted reproductive technology (ART) and intrauterine insemination (IUI) initiated in Europe during 2012: are there any changes compared with previous years? SUMMARY ANSWER: Despite some fluctuations in the number of countries reporting data, the overall number of ART cycles has continued to increase year by year, the pregnancy rates (PRs) in 2012 remained stable compared with those reported in 2011, and the number of transfers with multiple embryos (3+) and the multiple delivery rates were lower than ever before...
August 2016: Human Reproduction
Achilleas Papatheodorou, Pierre Vanderzwalmen, Yannis Panagiotidis, Stamatis Petousis, Giuseppe Gullo, Evangelia Kasapi, Maria Goudakou, Nikos Prapas, Kostas Zikopoulos, Ioannis Georgiou, Yannis Prapas
OBJECTIVE: To evaluate whether is possible to vitrify oocytes in an aseptic (hermetically closed) fashion and maintain clinical results comparable with those of fresh oocytes. DESIGN: Prospective, observational, cohort, noninferiority trial. SETTING: Private in vitro fertilization center. PATIENT(S): One hundred eighty-four recipients of donated vitrified oocytes. INTERVENTION(S): Closed system vitrification...
August 1, 2016: Fertility and Sterility
Anna Blázquez, Rita Vassena, Amelia Rodríguez, Francesc Figueras, Valerie Vernaeve
The number of women receiving in vitro fertilization cycles with both oocyte and sperm donation (double donation; DD) has grown globally in the last decade. The aim of this retrospective study, which included 1139 DD cycles, was to describe the characteristics of patients receiving DD and the outcomes of this assisted reproductive treatment. A cluster analysis identified couple 'status' as the main variable in dividing patients into categories. Three such status groups were identified for further analysis: (i) single women (SW), that is women without a partner either male or female; (ii) women with a male partner (MP); (iii) women with a female partner (FP)...
September 2016: Human Fertility: Journal of the British Fertility Society
Laura Andolfi, Elena Masiero, Elena Giolo, Monica Martinelli, Stefania Luppi, Simone Dal Zilio, Ines Delfino, Roberta Bortul, Marina Zweyer, Giuseppe Ricci, Marco Lazzarino
The role of mechanics in numerous biological processes is nowadays recognized, while in others, such as the fertilization process, it is still neglected. In the case of oocytes the description of their mechanical properties could improve the comprehension of the oocyte-spermatozoon interaction and be helpful for application in in vitro fertilization (IVF) clinics. Herein the mechanical properties of whole human oocytes (HOs) immediately after retrieval are investigated by indentation measurements with atomic force spectroscopy under physiological conditions...
August 8, 2016: Integrative Biology: Quantitative Biosciences From Nano to Macro
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