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https://www.readbyqxmd.com/read/28339687/extra-gonadal-oocytes-residing-in-the-mouse-ovarian-hilum-contribute-to-fertility1
#1
Xiaofei Sun, Junya Ito, Sarah J Potter, Sudhansu K Dey, Tony DeFalco
The observation of pups born from recipient and donor mice after ovariectomy followed by ovarian transplant poses the interesting possibility of an extra-ovarian source of oocytes. However, whether mammalian adult oocytes reside in extra-gonadal tissues remains elusive. Using transgenic fluorescent reporter mice and transplantation surgeries, we demonstrate the presence of both donor- and recipient-derived corpora lutea and recovery of both donor- and recipient-derived offspring from ovariectomized mice after transplantation of donor ovaries...
February 20, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/28339605/uniparental-chicken-offsprings-derived-from-oogenesis-of-chicken-primordial-germ-cells-zz-%C3%A2
#2
Chunhai Liu, Il-Kuk Chang, Kamal A Khazanehdari, Shruti Thomas, Preetha Varghese, Vijaya Baskar, Razan Alkhatib, Wenhai Li, Jörg Kinne, Michael J McGrew, Ulrich Wernery
Cloning (somatic cell nuclear transfer) in avian species has proven unachievable due to the physical structure of the avian oocyte. Here, the sexual differentiation of primordial germ cells with genetic sex ZZ (ZZ PGCs) was investigated in female germline chimeric chicken hosts with the aim to produce uniparental offspring. ZZ PGCs were expanded in culture and transplanted into the same and opposite sex chicken embryos which were partially sterilized using irradiation. All tested chimeric roosters (ZZ/ZZ) showed germline transmission with transmission rates of 3...
February 2, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/28336253/mitochondrial-matters-mitochondrial-bottlenecks-self-assembling-structures-and-entrapment-in-the-female-germline
#3
Florence L Marlow
Mitochondrial replacement therapy, a procedure to generate embryos with the nuclear genome of a donor mother and the healthy mitochondria of a recipient egg, has recently emerged as a promising strategy to prevent transmission of devastating mitochondrial DNA diseases and infertility. The procedure may produce an embryo that is free of diseased mitochondria. A recent study addresses important fundamental questions about the mechanisms underlying maternal inheritance and translational questions regarding the transgenerational effectiveness of this promising therapeutic strategy...
March 15, 2017: Stem Cell Research
https://www.readbyqxmd.com/read/28333245/euploidy-rates-in-donor-egg-cycles-significantly-differ-between-fertility-centers
#4
S Munné, M Alikani, L Ribustello, P Colls, Pedro A Martínez-Ortiz, D H McCulloh
STUDY QUESTION: Do external factors affect euploidy in egg donor cycles? SUMMARY ANSWER: The study demonstrates that during human assisted reproduction, embryonic chromosome abnormalities may be partly iatrogenic. WHAT IS KNOWN ALREADY: Chromosome abnormalities have been linked in the past to culture conditions such as temperature and Ph variations, as well as hormonal stimulation. Those reports were performed with older screening techniques (FISH), or ART methods no longer in use, and the subjects studied were not a homogeneous group...
March 2, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28333210/levels-of-trophectoderm-mitochondrial-dna-do-not-predict-the-reproductive-potential-of-sibling-embryos
#5
Nathan R Treff, Yiping Zhan, Xin Tao, Meir Olcha, Michael Han, Jessica Rajchel, Liza Morrison, Scott J Morin, Richard T Scott
STUDY QUESTION: What is the predictive value of trophectoderm mitochondrial DNA (mtDNA) quantity for blastocyst reproductive potential? SUMMARY ANSWER: This study demonstrates that, within a given cohort, mtDNA quantitation does not distinguish between embryos that implant and embryos that do not implant after double embryo transfer (DET). WHAT IS ALREADY KNOWN: An association between implantation failure and increased quantities of mtDNA has been observed in two studies but not in a third...
February 23, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28330533/-oocyte-donation-is-associated-with-an-increased-risk-of-complications-in-the-pregnant-woman-and-the-fetus
#6
Marianne Storgaard, Sara Malchau, Anne Loft, Elisabeth Larsen, Anja Pinborg
In Denmark, oocyte donation is allowed for women below 46 years of age if sperm from the woman's husband/partner is used, thus assuring genetic relationship with one parent. New legislation has provided more donors implying both shorter waiting time until treatment and more pregnancies achieved with donated oocytes. Oocyte donation pregnancies have increased risks of pre-eclampsia, post-partum bleeding, caesarean section, low birth weight and preterm birth, and since these risks are aggravated in multiple pregnancies, single embryo transfer is recommended...
March 13, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/28327456/relationship-between-plasma-anti-m%C3%A3-llerian-hormone-concentrations-during-the-rearing-period-and-subsequent-embryo-productivity-in-japanese-black-cattle
#7
H Nabenishi, G Kitahara, S Takagi, A Yamazaki, T Osawa
To use plasma anti-Müllerian hormone (AMH) concentrations as early-stage markers for donor cow selection, we investigated the relationship between plasma AMH concentrations in Japanese black heifers and subsequent embryo productivity following superovulation treatment. Plasma AMH and nonesterified fatty acid (NEFA) concentrations in 6 heifers were evaluated once per month from 3 mo before successful AI for primiparity to 3 mo postpartum. Following calving, embryo collection by superovulation treatment was performed at 3- to 4-mo intervals...
February 4, 2017: Domestic Animal Endocrinology
https://www.readbyqxmd.com/read/28322775/pregnancy-and-birth-outcomes-in-couples-with-infertility-with-and-without-assisted-reproductive-technology-with-an-emphasis-on-us-population-based-studies
#8
REVIEW
Barbara Luke
Infertility, defined as the inability to conceive within one year of unprotected intercourse, affects an estimated 80 million individuals worldwide, or 10-15 percent of couples of reproductive age. Assisted reproductive technology (ART) includes all infertility treatments to achieve conception; in vitro fertilization (IVF) is the process by which an oocyte is fertilized by semen outside the body; non-IVF ART treatments include ovulation induction, artificial insemination, and intrauterine insemination. Use of ART has risen steadily in the United States during the past two decades due to several reasons, including childbearing at older maternal ages and increasing insurance coverage...
March 18, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28299549/elective-single-blastocyst-transfer-in-advanced-maternal-age
#9
Samer Tannus, Weon-Young Son, Michael Haim Dahan
PURPOSE: The purpose of this study was to investigate reproductive outcomes following elective single blastocyst transfer (eSBT) compared with those of double blastocyst transfer (DBT) in advanced maternal age. METHODS: This was a retrospective cohort study performed at an academic fertility center. All women aged 40 and over for whom in vitro fertilization (IVF) cycles were performed and in whom embryo culture was extended to the blastocyst stage were reviewed for possible inclusion...
March 15, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28288197/dog-cloning-with-in-vivo-matured-oocytes-obtained-using-electric-chemiluminescence-immunoassay-predicted-ovulation-method
#10
Seunghoon Lee, Minghui Zhao, Jingu No, Yoonseok Nam, Gi-Sun Im, Tai-Young Hur
Radioactive immunoassay (RIA) is a traditional serum hormone assay method, but the application of the method in reproductive studies is limited by the associated radioactivity. The aim of present study was to evaluate the reliability of RIA and to compare its canine serum progesterone concentration determination accuracy to that of the electric chemiluminescence immunoassay (ECLI). In vivo matured oocytes were utilized for canine somatic cell nuclear transfer (SCNT), and serum progesterone levels were assessed to accurately determine ovulation and oocyte maturation...
2017: PloS One
https://www.readbyqxmd.com/read/28287092/loss-of-centromere-cohesion-in-aneuploid-human-oocytes-correlates-with-decreased-kinetochore-localization-of-the-sac-proteins-bub1-and-bubr1
#11
Julie Lagirand-Cantaloube, Cendrine Ciabrini, Sophie Charrasse, Alice Ferrieres, Anna Castro, Tal Anahory, Thierry Lorca
In human eggs, aneuploidy increases with age and can result in infertility and genetic diseases. Studies in mouse oocytes suggest that reduced centromere cohesion and spindle assembly checkpoint (SAC) activity could be at the origin of chromosome missegregation. Little is known about these two features in humans. Here, we show that in human eggs, inter-kinetochore distances of bivalent chromosomes strongly increase with age. This results in the formation of univalent chromosomes during metaphase I (MI) and of single chromatids in metaphase II (MII)...
March 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28285954/anti-m%C3%A3-llerian-hormone-concentrations-and-parity-in-fertile-women-the-model-of-oocyte-donors
#12
Sophie Catteau-Jonard, Marie Roux, Agathe Dumont, Anne-Sophie Delesalle, Geoffroy Robin, Didier Dewailly
In France until the end of 2015, oocyte donors must have had at least one child and be aged 18-37 years. This population of fertile women was selected to examine whether serum anti-Müllerian hormone (AMH) concentration could be a reliable correlate of spontaneous pregnancy in women who had proven their fertility before. A cohort of 217 women followed between 2009 and 2015 for oocyte donation at the University Hospital of Lille comprised this retrospective study. In these egg donors, aged 20-37 (median: 32 years), the median serum AMH level was 22 pmol/l (5-95th percentiles: 4...
March 1, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28283446/magnetic-cell-sorting-of-semen-containing-spermatozoa-with-high-dna-fragmentation-in-icsi-cycles-decreases-miscarriage-rate
#13
Pascual Sánchez-Martín, Mónica Dorado-Silva, Fernando Sánchez-Martín, Mercedes González Martínez, Stephen D Johnston, Jaime Gosálvez
This retrospective cohort study investigated whether reproductive outcome could be improved in couples presenting with a high level of sperm DNA fragmentation (SDF) by treating the ejaculate with the magnetic cell sorting (MACS) sperm selection procedure in combination with prior density gradient centrifugation (DGC). Only men presenting with ≥30% sperm DNA in the ejaculate were included because these patients can be potentially treated with MACS to reduce the proportion of sperm presenting DNA damage. In total, 305 couples were included in this study, and from these, 216 women underwent autologous ICSI (AUTO-ICSI), whereas the remaining 89 participated in oocyte donor ICSI (DONOR-ICSI)...
February 24, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28257859/transcriptomic-evaluation-of-bovine-blastocysts-obtained-from-peri-pubertal-oocyte-donors
#14
Léonie Morin-Doré, Patrick Blondin, Christian Vigneault, François-Xavier Grand, Rémi Labrecque, Marc-André Sirard
Assisted reproduction technologies (ART) and high selection pressure in the dairy industry are leading towards the use of younger females for reproduction, thereby reducing the interval between generations. This situation may have a negative impact on embryo quality, thus reducing the success rate of the procedures. This study aimed to document the effects of oocyte donor age on embryo quality, at the transcriptomic level, in order to characterize the effects of using young females for reproduction purpose...
April 15, 2017: Theriogenology
https://www.readbyqxmd.com/read/28250216/mouse-ovary-transplantation
#15
Richard Behringer
Ovary transplantation is a useful technique when there is a valuable female mouse (e.g., transgenic, unique allele) that is ill, not breeding, or cannot breed naturally. The ovaries from the valuable female are transplanted into a histocompatible wild-type female recipient whose ovaries have been surgically removed. The donor ovaries can then function in the wild-type recipient to generate oocytes that will be ovulated and can be fertilized after natural matings. The donor ovaries can be cut into smaller pieces and each piece can be transplanted into separate females...
March 1, 2017: Cold Spring Harbor Protocols
https://www.readbyqxmd.com/read/28216912/pregnancy-outcomes-and-maternal-and-perinatal-complications-of-pregnancies-following-in-vitro-fertilization-intracytoplasmic-sperm-injection-using-own-oocytes-donor-oocytes-and-vitrified-embryos-a-prospective-follow-up-study
#16
Manish Banker, Vidhisha Mehta, Dipesh Sorathiya, Mira Dave, Sandeep Shah
BACKGROUND: Several global studies have assessed maternal and perinatal outcomes and complications with the type of embryo transfer (ET) following in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI). The present study assessed the incidence of maternal and perinatal outcomes and complications following IVF/ICSI associated with the type of embryo transferred. METHODOLOGY: A total of 2112 ETs were performed in 2092 female patients aged 21-50 years between January 1 and December 31, 2014 (Group A: Fresh ET using self-oocytes: 691; Group B: Fresh ET using donor oocytes: 810; and Group C: Thaw ET using vitrified-warmed embryos: 611)...
October 2016: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/28215680/production-of-sperm-from-porcine-fetal-testicular-tissue-after-cryopreservation-and-grafting-into-nude-mice
#17
Hiroyuki Kaneko, Kazuhiro Kikuchi, Nguyen Thi Men, Michiko Nakai, Junko Noguchi, Naomi Kashiwazaki, Junya Ito
A major goal of testicular xenografting is to salvage germ cells from immature animals that cannot be used for reproduction and generate their offspring. In this study, we investigated whether porcine fetal testicular tissue would acquire the ability to produce sperm with full developmental competence after they had been cryopreserved and grafted into nude mice. Testicular fragments from fetuses at 35, 55 and 90 days postartificial insemination (dpi) were vitrified and stored in liquid nitrogen. Immediately after warming, testicular fragments at each fetal stage were transplanted under the back skin of castrated nude mice (Crlj:CD1-Foxn1(nu)) (35-, 55- and 90-dpi groups, respectively) (day 0 = grafting)...
March 15, 2017: Theriogenology
https://www.readbyqxmd.com/read/28215678/the-impact-of-ovarian-stimulation-protocol-on-oocyte-quality-subsequent-in%C3%A2-vitro-embryo-development-and-pregnancy-after-transfer-to-recipients-in-eld-s-deer-rucervus-eldii-thamin
#18
Ampika Thongphakdee, Debra K Berg, Theerawat Tharasanit, Nikorn Thongtip, Wanlaya Tipkantha, Chainarong Punkong, Daraka Tongthainan, Sakhon Noimoon, Umaporn Maikeaw, Nudthakamol Kajornklin, Boripat Siriaroonrat, Pierre Comizzoli, Sumate Kamolnorranath
Propagating genetically valuable individuals through oocyte collection, in vitro fertilization (IVF) and embryo transfer is critical to maintain sustainable populations of the endangered Eld's deer. The objectives of this study were to assess the impact of exogenous FSH injections on (1) the number and in vitro competence of oocytes collected and (2) the developmental potential of resulting IVF embryos after transfer into recipients during the breeding season (February-April). In a pilot experiment, estrus synchronization was conducted in three surplus females (using intravaginal progesterone-releasing devices, CIDRG for 14 days and injections of buserelin (a GnRH agonist)...
March 15, 2017: Theriogenology
https://www.readbyqxmd.com/read/28202723/mapping-of-voltage-sensor-positions-in-resting-and-inactivated-mammalian-sodium-channels-by-lret
#19
Tomoya Kubota, Thomas Durek, Bobo Dang, Rocio K Finol-Urdaneta, David J Craik, Stephen B H Kent, Robert J French, Francisco Bezanilla, Ana M Correa
Voltage-gated sodium channels (Navs) play crucial roles in excitable cells. Although vertebrate Nav function has been extensively studied, the detailed structural basis for voltage-dependent gating mechanisms remain obscure. We have assessed the structural changes of the Nav voltage sensor domain using lanthanide-based resonance energy transfer (LRET) between the rat skeletal muscle voltage-gated sodium channel (Nav1.4) and fluorescently labeled Nav1.4-targeting toxins. We generated donor constructs with genetically encoded lanthanide-binding tags (LBTs) inserted at the extracellular end of the S4 segment of each domain (with a single LBT per construct)...
March 7, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28202471/oocyte-shuttle-a-recombinant-protein-transporting-donor-dna-into-the-xenopus-oocyte-in-situ
#20
Duri Rungger, Lisbeth Muster, Oleg Georgiev, Elisabeth Rungger-Brändle
The newly developed oocyte shuttle protein contains a streptavidin moiety that tightly binds biotinylated DNA. Injected intravenously into adult Xenopus females, the protein-DNA complex is rapidly transported through the bloodstream and, within the ovary, the vitellogenin ligand present in the protein binds to the receptors at the surface of the oocytes. The bound complex is internalized and translocates into the oocyte nucleus thanks to an SV40 nuclear localization signal, enhanced by an adjacent casein kinase phosphorylation site...
February 15, 2017: Biology Open
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