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https://www.readbyqxmd.com/read/29782509/maternal-cardiovascular-and-endothelial-function-from-first-trimester-to-postpartum
#1
Vassiliki Kolovetsiou-Kreiner, Manfred Georg Moertl, Ilona Papousek, Karin Schmid-Zalaudek, Uwe Lang, Dietmar Schlembach, Mila Cervar-Zivkovic, Helmut Karl Lackner
OBJECTIVE: To explore noninvasively the complex interactions of the maternal hemodynamic system throughout pregnancy and the resulting after-effect six weeks postpartum. METHODS: Eighteen women were tested beginning at the 12th week of gestation at six time-points throughout pregnancy and six weeks postpartum. Heart rate, heart rate variability, blood pressure, pulse transit time (PTT), respiration, and baroreceptor sensitivity were analyzed in resting conditions...
2018: PloS One
https://www.readbyqxmd.com/read/29780388/regulation-of-hematopoietic-cell-development-and-function-through-phosphoinositides
#2
REVIEW
Mila Elich, Karsten Sauer
One of the most paramount receptor-induced signal transduction mechanisms in hematopoietic cells is production of the lipid second messenger phosphatidylinositol(3,4,5)trisphosphate (PIP3 ) by class I phosphoinositide 3 kinases (PI3K). Defective PIP3 signaling impairs almost every aspect of hematopoiesis, including T cell development and function. Limiting PIP3 signaling is particularly important, because excessive PIP3 function in lymphocytes can transform them and cause blood cancers. Here, we review the key functions of PIP3 and related phosphoinositides in hematopoietic cells, with a special focus on those mechanisms dampening PIP3 production, turnover, or function...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29778830/wearable-camera-derived-microenvironments-in-relation-to-personal-exposure-to-pm-2-5
#3
Maëlle Salmon, Carles Milà, Santhi Bhogadi, Srivalli Addanki, Pavitra Madhira, Niharika Muddepaka, Amaravathi Mora, Margaux Sanchez, Sanjay Kinra, V Sreekanth, Aiden Doherty, Julian D Marshall, Cathryn Tonne
Data regarding which microenvironments drive exposure to air pollution in low and middle income countries are scarce. Our objective was to identify sources of time-resolved personal PM2.5 exposure in peri-urban India using wearable camera-derived microenvironmental information. We conducted a panel study with up to 6 repeated non-consecutive 24 h measurements on 45 participants (186 participant-days). Camera images were manually annotated to derive visual concepts indicative of microenvironments and activities...
May 17, 2018: Environment International
https://www.readbyqxmd.com/read/29774831/urban-wild-boars-and-risk-for-zoonotic-streptococcus-suis-spain
#4
Xavier Fernández-Aguilar, Marcelo Gottschalk, Virginia Aragon, Jordi Càmara, Carmen Ardanuy, Roser Velarde, Nuria Galofré-Milà, Raquel Castillo-Contreras, Jorge R López-Olvera, Gregorio Mentaberre, Andreu Colom-Cadena, Santiago Lavín, Oscar Cabezón
Urban wild boars (Sus scrofa) from Barcelona, Spain, harbor great diversity of Streptococcus suis strains, including strains with the cps2 gene and with the same molecular profile as local human cases. The increasing trend of potential effective contacts for S. suis transmission is of public health concern.
June 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29764786/instability-in-patients-with-canvas-can-computerized-dynamic-posturography-help-in-diagnosis
#5
Alba Marina Milá de la Roca-Morales, Joan F Andreo-Marroig, Sofía Santos-Pérez, Andrés Soto-Varela
OBJECTIVE: To describe the pattern of dynamic posturography or its role in diagnosis in patients with cerebellar ataxia with neuropathy and vestibular arreflexia syndrome (CANVAS). MATERIALS AND METHODS: We present and describe posturographic data of four patients diagnosed with the CANVAS syndrome in a tertiary hospital. RESULTS: In all patients, the average balance score was diminished. Two patients presented a pattern of visual dependence...
April 2018: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/29719088/depressive-and-anxious-symptoms-and-20-year-mortality-evidence-from-the-stirling-county-study
#6
Ian Colman, Mila Kingsbury, Ewa Sucha, Nicholas J Horton, Jane M Murphy, Stephen E Gilman
BACKGROUND: Depression and anxiety disorders are highly comorbid, and share significant symptom overlap. Whereas depression has been consistently associated with excess mortality, the association between anxiety and mortality is less clear. Our aim was to identify constellations of anxious and depressive symptoms and examine their associations with mortality. METHOD: This study considers respondents from the 1970 (n = 1203) and 1992 (n = 1402) cohorts of the Stirling County study...
May 2, 2018: Depression and Anxiety
https://www.readbyqxmd.com/read/29717365/the-who-diagnostic-criteria-for-polycythemia-vera-role-of-red-cell-mass-versus-hemoglobin-hematocrit-level-and-morphology
#7
Ljubomir Jakovic, Mirjana Gotic, Heinz Gisslinger, Ivan Soldatovic, Dijana Sefer, Mila Tirnanic, Danijela Lekovic, Maja Perunicic Jovanovic, Martin Schalling, Bettina Gisslinger, Christine Beham-Schmid, Ingrid Simonitsch-Klupp, Jürgen Thiele
Regarding diagnosis of polycythemia vera (PV), discussion persists about hemoglobin (Hb) and/or hematocrit (Hct) threshold values as surrogate markers for red cell mass (RCM) and the diagnostic impact of bone marrow (BM) morphology. We performed a retrospective study on 290 patients with PV (151 males, 139 females; median age 65 years) presenting with characteristic BM features (initial biopsies, centralized evaluation) and endogenous erythroid colony (EEC) formations. This cohort included (1) a group of 229 patients when following the 2008 versus 256 patients diagnosed according to the 2016 World Health Organization (WHO) guidelines, all presented with increased RCM; (2) masked PV patients with low Hb (n = 143)/Hct (n = 45) recruited from the 2008 WHO cohort; (3) a cohort of 17 PV patients with elevated diagnostic Hb/Hct levels but low RCM; and (4) nine PV patients with increased RCM, opposing low Hb/Hct values...
May 1, 2018: Annals of Hematology
https://www.readbyqxmd.com/read/29701899/the-tomato-ethylene-response-factor-sl-erf-b3-integrates-ethylene-and-auxin-signaling-via-direct-regulation-of-sl-aux-iaa27
#8
Mingchun Liu, Yao Chen, Ya Chen, Jun-Hye Shin, Isabelle Mila, Corinne Audran, Mohamed Zouine, Julien Pirrello, Mondher Bouzayen
Plant growth and development is coordinated by complex networks of interacting hormones, and cross-talk between ethylene and auxin signaling is essential for a wide range of plant developmental processes. Nevertheless, the molecular links underlying the interaction between the two hormones remain poorly understood. In order to decipher the cross-talk between the Ethylene Response Factor Sl-ERF.B3 and Sl-IAA27, mediating ethylene and auxin signaling, respectively, we combined reverse genetic approaches, physiological methods, transactivation experiments and electrophoretic mobility shift assays...
April 27, 2018: New Phytologist
https://www.readbyqxmd.com/read/29701519/chylous-ascites-associated-with-abdominal-trauma-and-intestinal-resection-anastomosis-in-a-pet-ferret-mustela-putorius-furo
#9
Lucile Chassang, Isabelle Langlois, Pauline Loos, Mila Freire, Elizabeth O'Toole
CASE DESCRIPTION A 10-week-old 0.73-kg (1.6-lb) castrated male domestic ferret (Mustela putorius furo) was referred for exploratory laparotomy because of pneumoperitoneum and possible septic peritonitis after being bitten by the owner's dog. CLINICAL FINDINGS Abdominal exploration revealed a large laceration of the duodenum, tears of the jejunal mesentery, and 2 small tears in the abdominal wall. Chylous abdominal effusion developed 48 hours after surgery. TREATMENT AND OUTCOME Postoperative care included supportive treatment, analgesia, and antimicrobials...
May 15, 2018: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/29689494/angiogenic-factors-in-pregnancies-of-women-with-antiphospholipid-syndrome-and-systemic-lupus-erythematosus
#10
Karoline Mayer-Pickel, Christina Stern, Katharina Eberhard, Uwe Lang, Barbara Obermayer-Pietsch, Mila Cervar-Zivkovic
OBJECTIVES: An imbalance of angiogenic placental factors such as endoglin, soluble fms-like tyrosine kinase 1(sFlt-1) and placental growth factor (PlGF) has been implicated in the pathophysiology of preeclampsia. This study aimed to evaluate serum levels of sFlt-1, PlGF and endoglin in women with primary and secondary antiphospholipid Syndrome (APS) and systemic lupus erythematosus (SLE) longitudinally through pregnancy. MATERIAL AND METHODS: Serum levels of sFlt-1, PlGF and endoglin were measured prospectively at 4-week intervals (from gestational weeks 12-36) in 17 women with primary APS (PAPS), 18 women with secondary APS (SAPS), and 23 women with SLE...
April 18, 2018: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/29686423/clonal-cd4-t-cells-in-the-hiv-1-latent-reservoir-display-a-distinct-gene-profile-upon-reactivation
#11
Lillian B Cohn, Israel T da Silva, Renan Valieris, Amy S Huang, Julio C C Lorenzi, Yehuda Z Cohen, Joy A Pai, Allison L Butler, Marina Caskey, Mila Jankovic, Michel C Nussenzweig
Despite suppressive combination antiretroviral therapy (ART), latent HIV-1 proviruses persist in patients. This latent reservoir is established within 48-72 h after infection, has a long half-life1,2 , enables viral rebound when ART is interrupted, and is the major barrier to a cure for HIV-1 3 . Latent cells are exceedingly rare in blood (∼1 per 1 × 106 CD4+ T cells) and are typically enumerated by indirect means, such as viral outgrowth assays4,5 . We report a new strategy to purify and characterize single reactivated latent cells from HIV-1-infected individuals on suppressive ART...
April 23, 2018: Nature Medicine
https://www.readbyqxmd.com/read/29680378/characterisation-of-bergeyella-spp-isolated-from-the-nasal-cavities-of-piglets
#12
M Lorenzo de Arriba, S Lopez-Serrano, N Galofre-Mila, V Aragon
The aim of this study was to characterise bacteria in the genus Bergeyella isolated from the nasal passages of healthy piglets. Nasal swabs from 3 to 4 week-old piglets from eight commercial domestic pig farms and one wild boar farm were cultured under aerobic conditions. Twenty-nine Bergeyella spp. isolates were identified by partial 16S rRNA gene sequencing and 11 genotypes were discriminated by enterobacterial repetitive intergenic consensus (ERIC)-PCR. Bergeyella zoohelcum and Bergeyella porcorum were identified within the 11 genotypes...
April 2018: Veterinary Journal
https://www.readbyqxmd.com/read/29657434/inventory-of-lice-of-mammals-and-farmyard-chicken-in-north-eastern-algeria
#13
Mohamed Nadir Meguini, Souad Righi, Fayçal Zeroual, Khelaf Saidani, Ahmed Benakhla
Background and Aim: Lice are permanent ectoparasites, extremely specific to their hosts. Their great importance in veterinary medicine remain significant, they can cause their direct pathogenic actions like irritability, dermatitis, anemia, decreased weight gain, and milk production. The purpose of this work was to made the first time an inventory of mammalian lice in North-eastern Algeria. Materials and Methods: Our survey of lice infestation was conducted on several animal species from five provinces of North-eastern Algeria...
March 2018: Veterinary World
https://www.readbyqxmd.com/read/29651607/detecting-inflammation-in-inflammatory-bowel-disease-how-does-ultrasound-compare-to-magnetic-resonance-enterography-using-standardised-scoring-systems
#14
Joy L Barber, Alexsandra Zambrano-Perez, Øystein E Olsen, Fevronia Kiparissi, Mila Baycheva, Daniela Knaflez, Neil Shah, Tom A Watson
BACKGROUND: Magnetic resonance enterography (MRE) is the current gold standard for imaging in inflammatory bowel disease, but ultrasound (US) is a potential alternative. OBJECTIVE: To determine whether US is as good as MRE for the detecting inflamed bowel, using a combined consensus score as the reference standard. MATERIALS AND METHODS: We conducted a retrospective cohort study in children and adolescents <18 years with inflammatory bowel disease (IBD) at a tertiary and quaternary centre...
April 13, 2018: Pediatric Radiology
https://www.readbyqxmd.com/read/29629384/knowledge-attitudes-and-barriers-toward-research-the-perspectives-of-undergraduate-medical-and-dental-students
#15
Htoo Htoo Kyaw Soe, Nan Nitra Than, Htay Lwin, Mila Nu Nu Nu Htay, Khine Lynn Phyu, Adinegara Lutfi Abas
CONTEXT: Scientific research not only promotes health and combats diseases of an individual, but also it can strengthen the effectiveness of health systems. Hence, understanding of scientific methods becomes a crucial component in the medical profession. AIMS: This study was conducted to assess the knowledge, attitudes, and barriers toward research among undergraduate medical and dental students. SETTINGS AND DESIGN: This cross-sectional study was conducted among 295 undergraduate Bachelor of Medicine and Bachelor of Surgery (MBBS) and Bachelor of Dental Surgery (BDS) students from a private medical college in Malaysia...
2018: Journal of Education and Health Promotion
https://www.readbyqxmd.com/read/29626773/development-of-land-use-regression-models-for-fine-particles-and-black-carbon-in-peri-urban-south-india
#16
Margaux Sanchez, Albert Ambros, Carles Milà, Maëlle Salmon, Kalpana Balakrishnan, Sankar Sambandam, V Sreekanth, Julian D Marshall, Cathryn Tonne
Land-use regression (LUR) has been used to model local spatial variability of particulate matter in cities of high-income countries. Performance of LUR models is unknown in less urbanized areas of low-/middle-income countries (LMICs) experiencing complex sources of ambient air pollution and which typically have limited land use data. To address these concerns, we developed LUR models using satellite imagery (e.g., vegetation, urbanicity) and manually-collected data from a comprehensive built-environment survey (e...
April 4, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29615752/endothelial-indoleamine-2-3-dioxygenase-1-regulates-the-placental-vascular-tone-and-is-deficient-in-intrauterine-growth-restriction-and-pre-eclampsia
#17
Pablo Zardoya-Laguardia, Astrid Blaschitz, Birgit Hirschmugl, Ingrid Lang, Sereina A Herzog, Liudmila Nikitina, Martin Gauster, Martin Häusler, Mila Cervar-Zivkovic, Eva Karpf, Ghassan J Maghzal, Chris P Stanley, Roland Stocker, Christian Wadsack, Saša Frank, Peter Sedlmayr
Indoleamine 2,3-dioxygenase-1 (IDO1) mediates the degradation of L-tryptophan (L-Trp) and is constitutively expressed in the chorionic vascular endothelium of the human placenta with highest levels in the microvasculature. Given that endothelial expression of IDO1 has been shown to regulate vascular tone and blood pressure in mice under the condition of systemic inflammation, we asked whether IDO1 is also involved in the regulation of placental blood flow and if yes, whether this function is potentially impaired in intrauterine growth restriction (IUGR) and pre-eclampsia (PE)...
April 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29604051/clinical-implication-of-fmr1-intermediate-alleles-in-a-spanish-population
#18
M I Alvarez-Mora, I Madrigal, F Martinez, M I Tejada, S Izquierdo-Alvarez, P S-V de Saz, A Caro-Llopis, O Villate, B Rodríguez-Santiago, L A Pérez-Jurado, L Rodriguez-Revenga, M Milà
FMR1 premutation carriers (55-200 CGGs) are at risk of developing Fragile X-associated primary ovarian insufficiency as well as Fragile X-associated tremor/ataxia syndrome. FMR1 premutation alleles are also associated with a variety of disorders, including psychiatric, developmental, and neurological problems. However, there is major concern regarding clinical implications of smaller CGG expansions known as intermediate alleles (IA) or gray zone alleles (45-54 CGG). Although several studies have hypothesized that IA may be involved in the etiology of FMR1 premutation associated phenotypes, this association still remains unclear...
March 31, 2018: Clinical Genetics
https://www.readbyqxmd.com/read/29603912/photoselective-vaporization-of-the-prostate-with-the-180-w-xps-greenlight-laser-five-year-experience-of-safety-efficiency-and-functional-outcomes
#19
Khaled Ajib, Mila Mansour, Marc Zanaty, Mansour Alnazari, Pierre-Alain Hueber, Malek Meskawi, Roger Valdivieso, Come Tholomier, Benjamin Pradere, Vincent Misrai, Dean Elterman, Kevin C Zorn
INTRODUCTION: Transurethral resection of the prostate (TURP) is still considered the gold standard surgical treatment for symptomatic benign prostatic hyperplasia (BPH). However, photoselective vaporization of the prostate (PVP) has gained widespread global acceptance in national guidelines as a safe and effective alternative option. Nevertheless, further evidence is required to assess the durability of Greenlight PVP. Herein, we reported our five years PVP experience with the Greenlight 180W XPS laser system...
March 19, 2018: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/29600750/terpenes-phenylpropanoids-sulfur-and-other-essential-oil-constituents-as-inhibitors-of-cholinesterases
#20
Olivera Politeo, Franko Burcul, Ivica Blazevic, Mila Radan
Essential oils constituents are a diverse family of low molecular weight organic compounds with comprehensive biological activity. According to their chemical structure these active compounds can be divided into four major groups: terpenes, terpenoids, phenylpropenes, and "others". In addition, they may contain diverse functional groups according to which they can be classified as hydrocarbons (monoterpenes, sesquiterpenes, and aliphatic hydrocarbons); oxygenated compounds (monoterpene and sesquiterpene alcohols, aldehydes, ketones, esters, and other oxygenated compounds); and sulfur and/or nitrogen sulfur-containing compounds (thioesters, sulfides, isothiocyantes, nitriles, and others)...
March 29, 2018: Current Medicinal Chemistry
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