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https://www.readbyqxmd.com/read/28185782/acute-pulmonary-embolism-detection-with-ventilation-perfusion-spect-combined-with-full-dose-ct-what-is-the-best-option
#1
M Milà, J Bechini, A Vázquez, V Vallejos, M Tenesa, A Espinal, M Fraile, M Monreal
AIM: To compare diagnostic accuracy of Ventilation/Perfusion (V/P) single-photon emission computed tomography (SPECT) combined with simultaneous full-dose CT with a hybrid SPECT/CT scanner versus planar ventilation/perfusion (V/P) SPECT and CT angiography (CTA) in patients suspected with acute pulmonary embolism (PE). METHODS: Between 2009 and 2011, consecutive patients suspected of acute PE were referred for V/P SPECT/CT (reviewed board approved study). A contrast agent was administered to patients who had no contraindications...
February 6, 2017: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/28183735/new-insights-into-the-regulatory-function-of-cyfip1-in-the-context-of-wave-and-fmrp-containing-complexes
#2
Sabiha Abekhoukh, H Bahar Sahin, Mauro Grossi, Samantha Zongaro, Thomas Maurin, Irene Madrigal, Daniele Kazue-Sugioka, Annick Raas-Rothschild, Mohamed Doulazmi, Pilar Carrera, Andrea Stachon, Steven Scherer, Maria Rita Drula Do Nascimento, Alain Trembleau, Ignacio Arroyo, Szatmari Peter, Isabel M Smith, Montserrat Milà, Adam C Smith, Angela Giangrande, Isabelle Caillé, Barbara Bardoni
CYtoplasmic FMRP Interacting Protein 1 (CYFIP1) is a candidate gene for intellectual disability (ID), autism, schizophrenia and epilepsy. It is a member of a family of proteins that is very conserved during evolution, sharing high homology with dCYFIP, its Drosophila homolog. CYFIP1 interacts with the Fragile X Mental Retardation Protein (FMRP), whose absence causes the Fragile X Syndrome, and with the translation initiation factor eIF4E. It is a member of the WAVE Regulatory Complex (WRC), thus representing a link between translational regulation and actin cytoskeleton...
February 9, 2017: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/28174249/tracking-the-embryonic-stem-cell-transition-from-ground-state-pluripotency
#3
Tüzer Kalkan, Nelly Olova, Mila Roode, Carla Mulas, Heather J Lee, Isabelle Nett, Hendrik Marks, Rachael Walker, Hendrik G Stunnenberg, Kathryn S Lilley, Jennifer Nichols, Wolf Reik, Paul Bertone, Austin Smith
Mouse embryonic stem (ES) cells are locked into self-renewal by shielding from inductive cues. Release from this ground state in minimal conditions offers a system for delineating developmental progression from naive pluripotency. Here we examined the initial transition process. The ES cell population behaves asynchronously. We therefore exploited a short-half-life Rex1::GFP reporter to isolate cells either side of exit from naive status. Extinction of ES cell identity in single cells is acute. It occurs only after near-complete elimination of naïve pluripotency factors, but precedes appearance of lineage specification markers...
February 7, 2017: Development
https://www.readbyqxmd.com/read/28162023/comparison-of-two-risk-assessment-algorithms-for-preeclampsia-in-first-trimester-with-consecutive-intake-of-low-dose-aspirin-in-the-high-risk-group-an-observational-study
#4
Ioana-Claudia Lakovschek, Bence Csapo, Vassiliki Kolovetsiou-Kreiner, Karoline Mayer-Pickel, Philipp Reif, Christina Stern, Daniela Ulrich, Uwe Lang, Barbara Obermayer-Pietsch, Mila Cervar-Zivkovic
We analyzed outcome of women screened for preeclampsia with two different multifactorial risk algorithms (Predictor®Software by PerkinElmer; PERK-group:n = 214 and Viewpoint® by GE Healthcare; VIEW-group:n = 209) in first trimester. Women at high risk for developing preeclampsia were advised to take low-dose acetylsalicylic-acid(LDA). Screening positive rates for early onset preeclampsia differed significantly between the two groups (7.9% vs 26.3%;p = 0.000). According clinical use of screening test criteria LDA was prescribed in 63(29...
February 5, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28148663/pre-operative-functional-mobility-as-an-independent-determinant-of-inpatient-functional-recovery-after-total-knee-arthroplasty-during-three-periods-that-coincided-with-changes-in-clinical-pathways
#5
G van der Sluis, R A Goldbohm, J E Elings, M W Nijhuis-van der Sanden, R P Akkermans, R Bimmel, T J Hoogeboom, N L van Meeteren
AIMS: To investigate whether pre-operative functional mobility is a determinant of delayed inpatient recovery of activities (IRoA) after total knee arthroplasty (TKA) in three periods that coincided with changes in the clinical pathway. PATIENTS AND METHODS: All patients (n = 682, 73% women, mean age 70 years, standard deviation 9) scheduled for TKA between 2009 and 2015 were pre-operatively screened for functional mobility by the Timed-up-and-Go test (TUG) and De Morton mobility index (DEMMI)...
February 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/28147348/the-association-between-biomarker-profiles-etiology-of-chronic-kidney-disease-and-mortality
#6
David Langsford, Mila Tang, Hicham I Cheikh Hassan, Ognjenka Djurdjev, Manish M Sood, Adeera Levin
BACKGROUND: Prognosis in chronic kidney disease (CKD) for adverse outcomes differs substantially based on the etiology of CKD. We examined whether the biomarker profile differed based on CKD etiology and whether they were associated with mortality. METHODS: Prospective observational study of 1,157 patients, 663 with diabetic kidney disease (DKD), 273 with glomerulonephritis (GN), and 221 with cystic/interstitial disease (polycystic kidney disease, pyelonephritis or chronic tubulointerstitial nephritis [PCK/TIN]) were identified in the Canadian Study of Prediction of Dialysis, Death and Interim Cardiovascular events over Time cohort...
February 2, 2017: American Journal of Nephrology
https://www.readbyqxmd.com/read/28138770/could-cardiac-biomarkers-predict-neurogenic-pulmonary-edema-in-aneurysmal-subarachnoid-hemorrhage
#7
Tijana Nastasovic, Branko Milakovic, Jelena Eric Marinkovic, Danica Grujicic, Mila Stosic
BACKGROUND: Neurogenic pulmonary edema (NPE) is a clinical syndrome characterized by the acute onset of pulmonary edema after a significant central nervous system (CNS) insult. NPE occurs as a result of release of catecholamines into the blood immediately after aneurysm rupture. The aim of this study is to investigate the connection between the value of cardiac biomarkers on admission and incidence of NPE in patients with aneurysmal subarachnoid hemorrhage (SAH). METHODS: A total of 262 SAH patients (162 women, 100 men) were prospectively included in the study...
January 30, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28127693/erratum-to-comparison-of-in-vitro-test-systems-using-bacterial-and-mammalian-cells-for-genotoxicity-assessment-within-the-health-related-indication-value-hriv-concept
#8
Eva-Maria Prantl, Meike Kramer, Carsten K Schmidt, Martina Knauer, Stefan Gartiser, Aliaksandra Shuliakevich, Julia Milas, Hansruedi Glatt, Walter Meinl, Henner Hollert
No abstract text is available yet for this article.
January 27, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28124023/paget-s-disease-of-the-vulva-a-review-of-89-cases
#9
Cherry O Onaiwu, Mila Pontremoli Salcedo, Suzana A Pessini, Mark F Munsell, Elizabeth E Euscher, Kellie E Reed, Kathleen M Schmeler
The purpose of this study was to retrospectively review the clinical characteristics and outcomes of a series of women with Paget's disease of the vulva. A retrospective review was performed of 89 women with Paget's disease of the vulva evaluated at a single institution between 1966 and 2010. Medical records were reviewed for demographic information, clinical data, pathologic findings, treatment modalities and outcomes. We found that the primary treatment was surgery for 74 (83.1%) patients, with positive margins noted in 70...
February 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28093040/cadmium-in-liver-and-kidneys-of-domestic-balkan-and-alpine-dairy-goat-breeds-from-montenegro-and-serbia
#10
Vladimir Tomović, Marija Jokanović, Mila Tomović, Milana Lazović, Branislav Šojić, Snežana Škaljac, Maja Ivić, Sunčica Kocić-Tanackov, Igor Tomašević, Aleksandra Martinović
Concentrations of cadmium (Cd) were determined in the samples of 144 animals around 1 and of 144 animals around 4 years old. Cd was analyzed by Inductively Coupled Plasma-Optical Emission Spectrometry (ICP-OES), after microwave digestion. Cd concentrations were higher (p < 0.05) in kidney than in liver and higher (p < 0.05) in older animals than in young ones. In domestic Balkan goat which was raised in a free-ranged system Cd accumulation was lower (p < 0.05) than in Alpine goat raised in an intensive production system...
January 16, 2017: Food Additives & Contaminants. Part B, Surveillance
https://www.readbyqxmd.com/read/28070863/editorial
#11
EDITORIAL
Margherita Venturi, Mila D'Angelantonio
No abstract text is available yet for this article.
February 2017: Topics in Current Chemistry (Journal)
https://www.readbyqxmd.com/read/28063871/new-trends-in-human-and-animal-leptospirosis-in-croatia-2009-2014
#12
Josipa Habus, Zdenka Persic, Silvio Spicic, Silvijo Vince, Zrinka Stritof, Zoran Milas, Zeljko Cvetnic, Matko Perharic, Nenad Turk
Leptospirosis is a geographically widespread and globally underestimated zoonosis that affects humans and variety of animals. To identify trends and possible risk factors, joined medical and veterinary teams investigated epidemiology and epizootiology of leptospirosis in Croatia. Retrospective analysis of data obtained from referent diagnostic laboratories included a total of 1917 human and 123964 animal sera tested in the period from 2009 to 2014. We found high human leptospirosis average incidence rate of 1...
January 4, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28062026/mise-%C3%A3-jour-technique-sur-la-physiologie-et-l-%C3%A3-valuation-du-liquide-amniotique
#13
Kenneth I Lim, Kimberly Butt, Kentia Naud, Mila Smithies
OBJECTIF: RéSULTATS: SOURCES DES DONNéES PROBANTES: Nous avons effectué une recherche sur MEDLINE et Kfinder pour trouver des articles pertinents, puis avons examiné les bibliographies des articles retenus, notamment des revues Cochrane et des articles de revue récents. VALEURS: Les données recueillies ont été analysées par le Comité d'imagerie diagnostique de la Société des obstétriciens et gynécologues du Canada. Les recommandations ont été classées selon les critères établis par le Groupe d'étude canadien sur les soins de santé préventifs (Tableau 1)...
January 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/28062025/amniotic-fluid-technical-update-on-physiology-and-measurement
#14
Kenneth I Lim, Kimberly Butt, Kentia Naud, Mila Smithies
OBJECTIVE: OUTCOMES: EVIDENCE: A MEDLINE and KFINDER search was used to identify relevant articles, with review of bibliography identified article including Cochrane reviews and recent review articles. VALUES: The evidence collected was reviewed by the Diagnostic Imaging Committee of the Society of Obstetricians and Gynecologists of Canada. The recommendations were made according to the guidelines developed by The Canadian Task Force on Preventative Health Care (Table 1)...
January 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/28062001/identification-of-a-surface-epitope-specific-of-virulent-strains-of-haemophilus-parasuis
#15
Florencia Correa-Fiz, Nuria Galofre-Mila, Mar Costa-Hurtado, Virginia Aragon
Haemophilus parasuis is a bacterium from the Pasteurellaceae family that comprises strains of different degree of virulence. Non-virulent strains are considered components of the upper respiratory tract microbiota, while virulent strains can invade systemic organs and cause fibrinous polyserositis (Glässer's disease). Genomic comparison of virulent and non-virulent strains led to the identification of a family of genes differentially associated to virulence, the virulence-associated trimeric autotransporters (vtaA)...
January 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28001257/pregnancy-outcomes-after-chemotherapy-for-trophoblastic-neoplasia
#16
Mila Trementosa Garcia, Lawrence Hsu Lin, Koji Fushida, Rossana Pulcineli Vieira Francisco, Marcelo Zugaib
Introduction: The successful development of chemotherapy enabled a fertilitysparing treatment for patients with trophoblastic neoplasia. After disease remission, the outcome of a subsequent pregnancy becomes a great concern for these women. Objective: To analyze existing studies in the literature that describe the reproductive outcomes of patients with trophoblastic neoplasia treated with chemotherapy. Method: Systematic review was performed searching for articles on Medline/ Pubmed, Lilacs and Cochrane Library databases, using the terms "gestational trophoblastic disease" and "pregnancy outcome"...
December 2016: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/28000775/structural-basis-of-the-substrate-preference-towards-cmp-for-a-thymidylate-synthase-mila-involved-in-mildiomycin-biosynthesis
#17
Gong Zhao, Cheng Chen, Wei Xiong, Tuling Gao, Zixin Deng, Geng Wu, Xinyi He
Modified pyrimidine monophosphates such as methyl dCMP (mdCMP), hydroxymethyl dUMP (hmdUMP) and hmdCMP in some phages are synthesized by a large group of enzymes termed as thymidylate synthases (TS). Thymidylate is a nucleotide required for DNA synthesis and thus TS is an important drug target. In the biosynthetic pathway of the nucleoside fungicide mildiomycin isolated from Streptomyces rimofaciens ZJU5119, a cytidylate (CMP) hydroxymethylase, MilA, catalyzes the conversion of CMP into 5'-hydroxymethyl CMP (hmCMP) with an efficiency (kcat/KM) of 5-fold faster than for deoxycytidylate (dCMP)...
December 21, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27998928/the-cell-cycle-restricts-activation-induced-cytidine-deaminase-activity-to-early-g1
#18
Qiao Wang, Kyong-Rim Kieffer-Kwon, Thiago Y Oliveira, Christian T Mayer, Kaihui Yao, Joy Pai, Zhen Cao, Marei Dose, Rafael Casellas, Mila Jankovic, Michel C Nussenzweig, Davide F Robbiani
Activation-induced cytidine deaminase (AID) converts cytosine into uracil to initiate somatic hypermutation (SHM) and class switch recombination (CSR) of antibody genes. In addition, this enzyme produces DNA lesions at off-target sites that lead to mutations and chromosome translocations. However, AID is mostly cytoplasmic, and how and exactly when it accesses nuclear DNA remains enigmatic. Here, we show that AID is transiently in spatial contact with genomic DNA from the time the nuclear membrane breaks down in prometaphase until early G1, when it is actively exported into the cytoplasm...
January 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/27929542/autophagy-and-epithelial-mesenchymal-transition-an-intricate-interplay-in-cancer
#19
REVIEW
Mila Gugnoni, Valentina Sancisi, Gloria Manzotti, Greta Gandolfi, Alessia Ciarrocchi
Autophagy and epithelial to mesenchymal transition (EMT) are major biological processes in cancer. Autophagy is a catabolic pathway that aids cancer cells to overcome intracellular or environmental stress, including nutrient deprivation, hypoxia and drugs effect. EMT is a complex transdifferentiation through which cancer cells acquire mesenchymal features, including motility and metastatic potential. Recent observations indicate that these two processes are linked in a complex relationship. On the one side, cells that underwent EMT require autophagy activation to survive during the metastatic spreading...
December 8, 2016: Cell Death & Disease
https://www.readbyqxmd.com/read/27928753/comparison-of-in-vitro-test-systems-using-bacterial-and-mammalian-cells-for-genotoxicity-assessment-within-the-health-related-indication-value-hriv-concept
#20
Eva-Maria Prantl, Meike Kramer, Carsten K Schmidt, Martina Knauer, Stefan Gartiser, Aliaksandra Shuliakevich, Julia Milas, Hansruedi Glatt, Walter Meinl, Henner Hollert
In numerous cases, the German health-related indication value (HRIV) concept has proved its practicability for the assessment of drinking water relevant trace substances (Umweltbundesamt 2003). The HRIV is based on the toxicological profile of a substance. An open point of the HRIV concept has been the assignment of standardized test procedures to be used for the assessment. The level of the HRIV is at its lowest as soon as the genotoxicity of the substance is detected. As a single test on its own, it is not sufficient enough to assess the human toxicological relevance of a genotoxic effect or exclude it in the case of a negative result; a reasonable test battery was required, technically oriented towards the already harmonized international, hierarchical evaluation for toxicological assessment of chemicals...
December 8, 2016: Environmental Science and Pollution Research International
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