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https://www.readbyqxmd.com/read/27910232/strategies-of-readers-with-autism-when-responding-to-inferential-questions-an-eye-movement-study
#1
Martina Micai, Holly Joseph, Mila Vulchanova, David Saldaña
Previous research suggests that individuals with autism spectrum disorder (ASD) have difficulties with inference generation in reading tasks. However, most previous studies have examined how well children understand a text after reading or have measured on-line reading behavior without response to questions. The aim of this study was to investigate the online strategies of children and adolescents with autism during reading and at the same time responding to a question by monitoring their eye movements. The reading behavior of participants with ASD was compared with that of age-, language-, nonverbal intelligence-, reading-, and receptive language skills-matched participants without ASD (control group)...
December 2, 2016: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/27910138/canine-and-feline-colostrum
#2
S Chastant-Maillard, C Aggouni, A Albaret, A Fournier, H Mila
Puppy and kitten survival over the first weeks is particularly dependent on colostrum, a specific secretion of the mammary gland produced during the first 2 days post-partum. Colostrum is a source of nutrients and immunoglobulins. It also contributes to the digestive tract maturation. Colostrum differentiates from milk mainly based on its concentration in immunoglobulins G: 20-30 g/L in dog colostrum, 40-50 g/L in cats' vs <1 g/L in milk. IgG concentration rapidly drops after parturition (-50% in 24 hr)...
November 30, 2016: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/27886530/choosing-wisely-the-impact-of-patient-selection-on-efficacy-and-safety-outcomes-in-the-einstein-dvt-pe-and-amplify-trials
#3
Jan Beyer-Westendorf, Anthonie W A Lensing, Roopen Arya, Henri Bounameaux, Alexander T Cohen, Philip S Wells, Saskia Middeldorp, Peter Verhamme, Rodney Hughes, Nils Kucher, Akos F Pap, Mila Trajanovic, Martin H Prins, Paolo Prandoni, Jeffrey I Weitz
BACKGROUND: The results of the EINSTEIN-DVT/PE and AMPLIFY trials, which compared rivaroxaban and apixaban with conventional anticoagulation therapy for acute venous thromboembolism (VTE), respectively, are often compared. However, the trials differed in duration of therapy (3-12 and 6months, respectively) and in patient selection (few exclusion criteria and more stringent exclusion criteria, respectively). METHODS: To determine the effect of these methodological differences on outcomes, the patients enrolled in EINSTEIN-DVT/PE were divided into 2 cohorts; the 5253 patients that matched the exclusion criteria for AMPLIFY and were treated for at least 6months (cohort 1) and the 2368 patients who would have been ineligible for AMPLIFY (cohort 2)...
November 21, 2016: Thrombosis Research
https://www.readbyqxmd.com/read/27872426/gastric-tube-esophageal-reconstruction-in-children-with-esophageal-atresia-and-caustic-stricture-study-of-clinical-value-based-on-25-years-single-centre-experience
#4
Maja Milickovic, Djordje Savic, Blagoje Grujic, Aleksandar Vlahovic, Miroslav Vukadin, Mila Stajevic, Vladimir Kojovic
AIM: The aim of this study was estimation of clinical value of gastric tube esophagoplasty in children based on one single center experience. METHODS: Forty - nine patients with diagnosis of EA (n=22) and caustic esophageal injury (n=27) had undergone reverse gastric tube esophagoplasty during 25 years at our institution. Almost all EA patients received initially gastrostomy and cervical esophagostomy. Majority of CS patients had initially repeated dilatation therapy...
November 21, 2016: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/27872306/paired-quantitative-and-qualitative-assessment-of-the-replication-competent-hiv-1-reservoir-and-comparison-with-integrated-proviral-dna
#5
Julio C C Lorenzi, Yehuda Z Cohen, Lillian B Cohn, Edward F Kreider, John P Barton, Gerald H Learn, Thiago Oliveira, Christy L Lavine, Joshua A Horwitz, Allison Settler, Mila Jankovic, Michael S Seaman, Arup K Chakraborty, Beatrice H Hahn, Marina Caskey, Michel C Nussenzweig
HIV-1-infected individuals harbor a latent reservoir of infected CD4(+) T cells that is not eradicated by antiretroviral therapy (ART). This reservoir presents the greatest barrier to an HIV-1 cure and has remained difficult to characterize, in part, because the vast majority of integrated sequences are defective and incapable of reactivation. To characterize the replication-competent reservoir, we have combined two techniques, quantitative viral outgrowth and qualitative sequence analysis of clonal outgrowth viruses...
November 21, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27871846/the-oxidant-antioxidant-equilibrium-activities-of-selected-lysosomal-enzymes-and-activity-of-acute-phase-protein-in-peripheral-blood-of-18-year-old-football-players-after-aerobic-cycle-ergometer-test-combined-with-ice-water-immersion-or-recovery-at-room-temperature
#6
Paweł Sutkowy, Alina Woźniak, Tomasz Boraczyński, Michał Boraczyński, Celestyna Mila-Kierzenkowska
The goal of the study was to evaluate the effect of an aerobic exercise bout followed by ice-water immersion or recovery at room temperature on the redox state, activities of selected lysosomal enzymes and activity of α1-antitrypsin (AAT) in the blood of healthy sportsmen. Eleven amateur football players aged 18 were randomly assigned to two similar 30-min aerobic cycle ergometer tests followed by a recovery at room temperature (20 °C; Experiment 1) or ice-water immersion (3 °C, 5 min; Experiment 2). Peripheral blood was collected three times during both study experiments: before (baseline), as well as 20 and 40 min after the recovery or immersion...
November 18, 2016: Cryobiology
https://www.readbyqxmd.com/read/27866156/hide-and-seek-the-interplay-between-cancer-stem-cells-and-the-immune-system
#7
REVIEW
Mohammad Sultan, Krysta Mila Coyle, Dejan Vidovic, Margaret Lois Thomas, Shashi Gujar, Paola Marcato
The enhanced ability of cancer stem cells (CSCs) to give rise to new tumors suggests that these cells may also have an advantage in evading immune detection and elimination. This tumor-forming ability, combined with the known plasticity of the immune system, which can play both pro-tumorigenic and anti-tumorigenic roles, has motivated investigations into the interaction between CSCs and the immune system. Herein, we review the interplay between host immunity and CSCs by examining the immune-related mechanisms which favor CSCs and the CSC-mediated expansion of pro-tumorigenic immune cells...
November 19, 2016: Carcinogenesis
https://www.readbyqxmd.com/read/27862578/rapid-postglacial-diversification-and-long-term-stasis-within-the-songbird-genus-junco-phylogeographic-and-phylogenomic-evidence
#8
Guillermo Friis, Pau Aleixandre, Ricardo Rodríguez-Estrella, Adolfo G Navarro-Sigüenza, Borja Milá
Natural systems composed of closely-related taxa that vary in the degree of phenotypic divergence and geographic isolation, provide an opportunity to investigate the rate of phenotypic diversification and the relative roles of selection and drift in driving lineage formation. The genus Junco (Aves: Emberizidae) of North America includes parapatric northern forms that are markedly divergent in plumage pattern and color, in contrast to geographically isolated southern populations in remote areas that show moderate phenotypic divergence...
November 14, 2016: Molecular Ecology
https://www.readbyqxmd.com/read/27862411/natural-and-artificial-hyperimmune-solutions-impact-on-health-in-puppies
#9
H Mila, A Grellet, C Mariani, A Feugier, B Guard, J Suchodolski, J Steiner, S Chastant-Maillard
Colostrum and milk are complex mammary secretions providing the puppy with many nutritional and immunological factors, which play a crucial role for its correct development and survival. In the case of colostrum and/or milk intake deficiency, puppies are at increased risk of infectious diseases. This work reviews the various nutritional hyperimmune supplementations proposed to provide a passive immune protection and to positively impact puppies' health. Some strategies rely on canine immunoglobulins: canine colostrum banking and canine serum/plasma supplementation...
November 15, 2016: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/27853999/quantifying-the-exposure-of-tapentadol-extended-release-in-japanese-patients-with-cancer-pain-and-bridging-tapentadol-pharmacokinetics-across-populations-using-a-modeling-approach
#10
Liping Zhang, Xiaoyu Yan, Sayori Nobe, Peter Zannikos, Mila Etropolski, Partha Nandy
BACKGROUND AND OBJECTIVES: Tapentadol extended release (ER) is approved for the management of chronic and acute pain in adults. There has been no report of tapentadol ER pharmacokinetics in subjects with cancer pain. This analysis investigated tapentadol ER pharmacokinetics in Japanese patients with cancer pain and bridged it with the pharmacokinetics in Japanese healthy subjects and Caucasian patients with cancer pain. METHODS: Nonlinear mixed-effect pharmacokinetic modeling was conducted based on pooled tapentadol ER concentration data collected in five Phase 1 studies from 138 Japanese and Korean healthy subjects and in two Phase 3 studies from 215 Japanese and Korean subjects with cancer pain...
November 17, 2016: Clinical Drug Investigation
https://www.readbyqxmd.com/read/27833045/reciprocal-relationship-between-membrane-type-1-matrix-metalloproteinase-and-the-algesic-peptides-of-myelin-basic-protein-contributes-to-chronic-neuropathic-pain
#11
Sanghyun Hong, Albert G Remacle, Sergei A Shiryaev, Wonjun Choi, Swathi Hullugundi, Jennifer Dolkas, Mila Angert, Tasuku Nishihara, Tony L Yaksh, Alex Y Strongin, Veronica I Shubayev
Myelin basic protein (MBP) is an auto-antigen able to induce intractable pain from innocuous mechanical stimulation (mechanical allodynia). The mechanisms provoking this algesic MBP activity remain obscure. Our present study demonstrates that membrane type 1 matrix metalloproteinase (MT1-MMP/MMP-14) releases the algesic MBP peptides from the damaged myelin, which then reciprocally enhance the expression of MT1-MMP in nerve to sustain a state of allodynia. Specifically, MT1-MMP expression and activity in rat sciatic nerve gradually increased starting at day 3 after chronic constriction injury (CCI)...
November 7, 2016: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/27821221/chromatin-fractal-organization-textural-patterns-and-circularity-of-nuclear-envelope-in-adrenal-zona-fasciculata-cells
#12
Igor Pantic, Dejan Nesic, Milos Basailovic, Mila Cetkovic, Sanja Mazic, Jelena Suzic-Lazic, Martin Popevic
Despite previous research efforts in the fields of histology and cell physiology, the relationship between chromatin structural organization and nuclear shape remains unclear. The aim of this research was to test the existence and strength of correlations between mathematical parameters of chromatin microarchitecture and roundness of the nuclear envelope. On a sample of 240 nuclei of adrenal zona fasciculata cells stained using the DNA-specific Feulgen method, we quantified fractal parameters such as fractal dimension and lacunarity, as well as textural parameters such as angular second moment (ASM), entropy, inverse difference moment, contrast, and variance...
November 8, 2016: Microscopy and Microanalysis
https://www.readbyqxmd.com/read/27812963/occurrence-and-behavior-of-selected-pharmaceuticals-during-riverbank-filtration-in-the-republic-of-serbia
#13
Srđan Kovačević, Marina Radišić, Mila Laušević, Milan Dimkić
The objectives of the research are to determine the occurrence of pharmaceuticals in surface water and groundwater in the Republic of Serbia and to identify significant effects of river-water purification through riverbank filtration, concerning oxic conditions and hydrogeological conditions of alluvial aquifers in Serbia. Between 2009 and 2015, a total of 19 studied pharmaceuticals and metabolites were analyzed in 184 samples, 10 were detected in surface water, and 8 in groundwater. Carbamazepine and metamizole metabolites N-acetyl-4-amino-antipyrine (4-AAA) and N-formyl-4-amino-antipyrine (4-FAA) have the highest frequency of occurrence in surface water (57...
November 3, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27812308/daily-salivary-cortisol-profile-insights-from-the-croatian-late-adolescence-stress-study-class
#14
Daniela Šupe-Domić, Goran Milas, Irena Drmić Hofman, Lada Rumora, Irena Martinović Klarić
INTRODUCTION: The aim of the study was to examine basal hypothalamic-pituitary-adrenal (HPA) axis activity and to determine associations of various covariates (gender, sleep-wake rhythm, demographic, academic, life style and health-related characteristics) with altered daily salivary cortisol profiles in late adolescence. MATERIALS AND METHODS: The total analytic sample consisted of 903 Croatian secondary school students aged 18 - 21 years (median 19 years). Salivary cortisol was sampled at home at three time points over the course of one week and its concentrations were measured by using the enzyme immunoassay...
October 15, 2016: Biochemia Medica: časopis Hrvatskoga Društva Medicinskih Biokemičara
https://www.readbyqxmd.com/read/27807902/epidemiological-analysis-of-reproductive-performances-and-kitten-mortality-rates-in-5-303-purebred-queens-of-45-different-breeds-and-28-065-kittens-in-france
#15
A Fournier, M Masson, F Corbière, H Mila, C Mariani, A Grellet, S Chastant-Maillard
Reproduction management and performances are evaluated in the feline species only through a limited number of animals and studies. Our objective was to provide reference figures in purebred cats, from a large-scale sample. Data were collected from an online software dedicated to cattery management (Breeding Management System®, BMS, Royal Canin, Aimargues, France). Information was recorded on a voluntary basis by French breeders between 2011 and 2014. Data were anonymously transferred for analysis. A total of 9,063 oestrous periods (in contact with a male) from 5,303 queens (45 breeds) were recorded from 1,521 breeders...
November 3, 2016: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/27807805/identification-of-heterozygous-single-and-multi-exon-deletions-in-il7r-by-whole-exome-sequencing
#16
Karin R Engelhardt, Yaobo Xu, Angela Grainger, Mila G C Germani Batacchi, David J Swan, Joseph D P Willet, Intan J Abd Hamid, Philipp Agyeman, Dawn Barge, Shahnaz Bibi, Lucy Jenkins, Terence J Flood, Mario Abinun, Mary A Slatter, Andrew R Gennery, Andrew J Cant, Mauro Santibanez Koref, Kimberly Gilmour, Sophie Hambleton
PURPOSE: We aimed to achieve a retrospective molecular diagnosis by applying state-of-the-art genomic sequencing methods to past patients with T-B+NK+ severe combined immunodeficiency (SCID). We included identification of copy number variations (CNVs) by whole exome sequencing (WES) using the CNV calling method ExomeDepth to detect gene alterations for which routine Sanger sequencing analysis is not suitable, such as large heterozygous deletions. METHODS: Of a total of 12 undiagnosed patients with T-B+NK+ SCID, we analyzed eight probands by WES, using GATK to detect single nucleotide variants (SNVs) and small insertions and deletions (INDELs) and ExomeDepth to detect CNVs...
November 2, 2016: Journal of Clinical Immunology
https://www.readbyqxmd.com/read/27792381/chiral-spin-liquids-in-triangular-lattice-su-n-fermionic-mott-insulators-with-artificial-gauge-fields
#17
Pierre Nataf, Miklós Lajkó, Alexander Wietek, Karlo Penc, Frédéric Mila, Andreas M Läuchli
We show that, in the presence of a π/2 artificial gauge field per plaquette, Mott insulating phases of ultracold fermions with SU(N) symmetry and one particle per site generically possess an extended chiral phase with intrinsic topological order characterized by an approximate ground space of N low-lying singlets for periodic boundary conditions, and by chiral edge states described by the SU(N)_{1} Wess-Zumino-Novikov-Witten conformal field theory for open boundary conditions. This has been achieved by extensive exact diagonalizations for N between 3 and 9, and by a parton construction based on a set of N Gutzwiller projected fermionic wave functions with flux π/N per triangular plaquette...
October 14, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27774729/efficient-methods-for-isolating-five-phytochemicals-from-gentiana-macrophylla-using-high-performance-countercurrent-chromatography
#18
Taewoong Rho, Mila Jung, Min Won Lee, Young-Won Chin, Kee Dong Yoon
Efficient high-performance countercurrent chromatography methods were developed to isolate five typical compounds from the extracts of Gentiana macrophylla. n-Butanol-soluble extract of G. macrophylla contained three hydrophilic iridoids, loganic acid (1), swertiamarin (2) and gentiopicroside (3), and a chromene derivative, macrophylloside D (4) which were successfully isolated by flow rate gradient (1.5 mL/min in 0-60 min, 5.0 mL/min in 60-120 min), and consecutive flow rate gradient HPCCC using n-butanol/0...
October 24, 2016: Journal of Separation Science
https://www.readbyqxmd.com/read/27771901/impaired-mitochondrial-function-and-dynamics-in-the-pathogenesis-of-fxtas
#19
M I Alvarez-Mora, L Rodriguez-Revenga, I Madrigal, M Guitart-Mampel, G Garrabou, M Milà
Mitochondrial involvement plays an important role in neurodegenerative diseases. At least one-third of adult carriers of a FMR1 premutation (55-200 CGG repeats) are at risk of presenting an adult-onset neurodegenerative disorder known as fragile X-associated tremor/ataxia syndrome (FXTAS). In an attempt to provide new insights into the mechanisms involved in the pathogenesis of FXTAS, we characterized mitochondrial function and dynamics by the assessment of oxidative respiratory chain function, mitochondrial content, oxidative stress levels, and mitochondrial network complexity...
October 22, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27768283/independent-validation-of-national-satellite-based-land-use-regression-models-for-nitrogen-dioxide-using-passive-samplers
#20
Luke David Knibbs, Craig P Coorey, Matthew John Bechle, Christine Therese Cowie, Mila Dirgawati, Jane S Heyworth, Guy Barrington Marks, Julian D Marshall, Lidia Morawska, Gavin Pereira, Michael G Hewson
Including satellite observations of nitrogen dioxide (NO2) in land-use regression (LUR) models can improve their predictive ability, but requires rigorous evaluation. We used 123 passive NO2 samplers sited to capture within-city and near-road variability in two Australian cities (Sydney and Perth) to assess the validity of annual mean NO2¬ estimates from existing national satellite-based LUR models (developed with 68 regulatory monitors). The samplers spanned roadside, urban near traffic (≤100 m to a major road), and urban background (>100 m to a major road) locations...
October 21, 2016: Environmental Science & Technology
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