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https://www.readbyqxmd.com/read/28184276/segregation-for-reduction-of-regulated-medical-waste-in-the-operating-room-a-case-report
#1
Helen Ki Shinn, Youngyoen Hwang, Byung-Gun Kim, Chunwoo Yang, WonJu Na, Jang-Ho Song, Hyun Kyoung Lim
One-third of all hospital-regulated medical waste (RMW) comes from the operating room (OR), and it considerably consists of disposable packaging and wrapping materials for the sterilization of surgical instruments. This study sought to identify the amount and type of waste produced by ORs in order to reduce the RMW so as to achieve environmentally-friendly waste management in the OR. We performed an initial waste segregation of 4 total knee replacement arthroplasties (TKRAs) and 1 total hip replacement arthroplasty, and later of 1 extra TKRA, 1 laparoscopic anterior resection of the colon, and 1 pelviscopy (with radical vaginal hysterectomy), performed at our OR...
February 2017: Korean Journal of Anesthesiology
https://www.readbyqxmd.com/read/28163377/destruction-of-biological-particles-using-non-thermal-plasma
#2
REVIEW
Akira Mizuno
Mechanism of inactivation of bio-particles exposed to non-thermal plasma (NTP), namely, dielectric barrier discharge (DBD), and plasma jet (PJ), has been studied using E. coli, B. subtilis spore, S. cerevisiae and bacteriophages. States of different biological components were monitored during the course of inactivation. Analysis of green fluorescent protein, GFP, introduced into E. coli. or B. subtiles spore cells proved that radicals generated by NTP penetrate into microbes, destroying the cell membrane and finally damage the genes...
January 2017: Journal of Clinical Biochemistry and Nutrition
https://www.readbyqxmd.com/read/28119764/relevant-in-vitro-predictors-of-human-acellular-dermal-matrix-associated-inflammation-and-capsule-formation-in-a-nonhuman-primate-subcutaneous-tissue-expander-model
#3
Maryellen Sandor, Patrick Leamy, Pearl Assan, Amardeep Hoonjan, Li-Ting Huang, Marianne Edwards, Wenqi Zuo, Hui Li, Hui Xu
Objective: Benchtop methods were evaluated for preclinical inflammation/capsule formation correlation following implantation of human acellular dermal matrices. Methods: Dermal matrices were compared with native dermis for structure (histology, scanning electron microscopy), collagen solubility (hydroxyproline), enzymatic susceptibility (collagenase), and thermal stability (differential scanning calorimetry). Results were compared with implantation outcomes in a primate tissue expander model. Results: Native dermis, electron beam-sterilized, and freeze-dried human acellular dermal matrices had equivalent morphology, acid-soluble collagen (60...
2017: Eplasty
https://www.readbyqxmd.com/read/28118825/optimization-of-mosquito-egg-production-under-mass-rearing-setting-effects-of-cage-volume-blood-meal-source-and-adult-population-density-for-the-malaria-vector-anopheles-arabiensis
#4
Wadaka Mamai, Nanwintoum S Bimbile-Somda, Hamidou Maiga, José Guillermo Juarez, Zaynab A I Muosa, Adel Barakat Ali, Rosemary Susan Lees, Jeremie R L Gilles
BACKGROUND: Anopheles arabiensis is one of the major malaria vectors that put millions of people in endemic countries at risk. Mass-rearing of this mosquito is crucial for strategies that use sterile insect technique to suppress vector populations. The sterile insect technique (SIT) package for this mosquito species is being developed by the Insect Pest Control Subprogramme of the Joint FAO/IAEA Division of Nuclear Techniques in Food and Agriculture. To improve mass-rearing outcomes for An...
January 24, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28113914/system-on-chip-considerations-for-heterogeneous-integration-of-cmos-and-fluidic-bio-interfaces
#5
Timir Datta-Chaudhuri, Elisabeth Smela, Pamela A Abshire
CMOS chips are increasingly used for direct sensing and interfacing with fluidic and biological systems. While many biosensing systems have successfully combined CMOS chips for readout and signal processing with passive sensing arrays, systems that co-locate sensing with active circuits on a single chip offer significant advantages in size and performance but increase the complexity of multi-domain design and heterogeneous integration. This emerging class of lab-on-CMOS systems also poses distinct and vexing technical challenges that arise from the disparate requirements of biosensors and integrated circuits (ICs)...
April 21, 2016: IEEE Transactions on Biomedical Circuits and Systems
https://www.readbyqxmd.com/read/28055826/system-on-chip-considerations-for-heterogeneous-integration-of-cmos-and-fluidic-bio-interfaces
#6
Timir Datta-Chaudhuri, Elisabeth Smela, Pamela A Abshire
CMOS chips are increasingly used for direct sensing and interfacing with fluidic and biological systems. While many biosensing systems have successfully combined CMOS chips for readout and signal processing with passive sensing arrays, systems that co-locate sensing with active circuits on a single chip offer significant advantages in size and performance but increase the complexity of multi-domain design and heterogeneous integration. This emerging class of lab-on-CMOS systems also poses distinct and vexing technical challenges that arise from the disparate requirements of biosensors and integrated circuits (ICs)...
December 2016: IEEE Transactions on Biomedical Circuits and Systems
https://www.readbyqxmd.com/read/27927920/validation-of-autoclave-protocols-for-successful-decontamination-of-category-a-medical-waste-generated-from-care-of-patients-with-serious-communicable-diseases
#7
Brian T Garibaldi, Mallory Reimers, Neysa Ernst, Gregory Bova, Elaine Nowakowski, James Bukowski, Brandon C Ellis, Chris Smith, Lauren Sauer, Kim Dionne, Karen C Carroll, Lisa L Maragakis, Nicole M Parrish
In response to the Ebola outbreak in 2014, many hospitals designated specific areas to care for patients with Ebola and other highly infectious diseases. The safe handling of category A infectious substances is a unique challenge in this environment. One solution is on-site waste treatment with a steam sterilizer or autoclave. The Johns Hopkins Hospital (JHH) installed two pass-through autoclaves in its biocontainment unit (BCU). The JHH BCU and The Johns Hopkins biosafety level 3 (BSL-3) clinical microbiology laboratory designed and validated waste-handling protocols with simulated patient trash to ensure adequate sterilization...
February 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/27884664/bacterial-contamination-of-saline-used-for-epidural-procedures-in-an-obstetric-setting-a-randomised-comparison-of-two-drawing-up-techniques
#8
M Onofrei, M Y Wee, B Parker, N Wee, S Hill
BACKGROUND: There is little evidence to inform practice regarding the optimum aseptic technique of drawing up saline for epidural insertion. Our regional practice is to draw up saline from a non-sterile packaged plastic ampoule, therefore introducing the risk of bacterial contamination. Usually, the anaesthetist draws up saline directly from the vial held by an assistant using a needle (needle technique). Alternatively, the saline vial is emptied onto a sterile tray by an assistant and then drawn up by the anaesthetist (tray technique)...
February 2017: International Journal of Obstetric Anesthesia
https://www.readbyqxmd.com/read/27843253/acidogenic-potential-of-plain-milk-milk-with-sugar-milk-with-cornflakes-and-milk-cornflakes-with-sugar-a-comparative-study
#9
REVIEW
Sham S Bhat, Sundeep K Hegde, Vidya S Bhat, K M Ramya, Praveen S Jodalli
AIM: To compare the acidogenic potential of plain milk, milk with sugar, milk with cornflakes, and milk cornflakes with sugar by assessing the salivary pH. MATERIALS AND METHODS: The study was carried out on 40 school children of 8 to 12 years; 20 boys and 20 girls were randomly selected. The salivary pH was assessed before and after the consumption of milk; milk and sugar; milk and cornflakes; and milk, sugar, and cornflakes. Baseline unstimulated saliva was collected in sterile plastic tube and the pH was recorded...
July 2016: International Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/27789803/container-closure-integrity-testing-practical-aspects-and-approaches-in-the-pharmaceutical-industry
#10
Helen Brown, Hanns-Christian Mahler, James Mellman, Alejandra Nieto, Daniel Wagner, Matthias Schaar, Roman Mathaes, Juergen Kossinna, Franz Schmitting, Sascha Dreher, Holger Roehl, Markus Hemminger, Klaus Wuchner
The assurance of sterility of a parenteral drug product, prior to any human use, is a regulatory requirement. Hence, all strategies related to container closure integrity (CCI) must demonstrate absence of microbial contamination through leaks as part of the container closure system (CCS) qualification, during manufacturing, for Quality Control purposes and to ensure microbiological integrity (sterility) during storage and shipment up to the end of product shelf life. Current regulatory guidances, which differ between countries and regions, provide limited detail on how to assess CCI...
October 27, 2016: PDA Journal of Pharmaceutical Science and Technology
https://www.readbyqxmd.com/read/27773471/can-the-design-of-glove-dispensing-boxes-influence-glove-contamination
#11
O Assadian, D J Leaper, A Kramer, K J Ousey
BACKGROUND: Few studies have explored the microbial contamination of glove boxes in clinical settings. The objective of this observational study was to investigate whether a new glove packaging system in which single gloves are dispensed vertically, cuff end first, has lower levels of contamination on the gloves and on the surface around the box aperture compared with conventional glove boxes. METHODS: Seven participating sites were provided with vertical glove dispensing systems (modified boxes) and conventional boxes...
November 2016: Journal of Hospital Infection
https://www.readbyqxmd.com/read/27717732/evidence-that-the-endometrial-microbiota-has-an-effect-on-implantation-success-or-failure
#12
Inmaculada Moreno, Francisco M Codoñer, Felipe Vilella, Diana Valbuena, Juan F Martinez-Blanch, Jorge Jimenez-Almazán, Roberto Alonso, Pilar Alamá, Jose Remohí, Antonio Pellicer, Daniel Ramon, Carlos Simon
BACKGROUND: Bacterial cells in the human body account for 1-3% of total body weight and are at least equal in number to human cells. Recent research has focused on understanding how the different bacterial communities in the body (eg, gut, respiratory, skin, and vaginal microbiomes) predispose to health and disease. The microbiota of the reproductive tract has been inferred from the vaginal bacterial communities, and the uterus has been classically considered a sterile cavity. However, while the vaginal microbiota has been investigated in depth, there is a paucity of consistent data regarding the existence of an endometrial microbiota and its possible impact in reproductive function...
December 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27662636/the-effects-of-irradiation-on-the-biological-and-biomechanical-properties-of-an-acellular-porcine-superflexor-tendon-graft-for-cruciate-ligament-repair
#13
Jennifer H Edwards, Anthony Herbert, Gemma L Jones, Iain W Manfield, John Fisher, Eileen Ingham
Acellular xenogeneic tissues have the potential to provide 'off-the-shelf' grafts for anterior cruciate ligament (ACL) repair. To ensure that such grafts are sterile following packaging, it is desirable to use terminal sterilization methods. Here, the effects of gamma and electron beam irradiation on the biological and biomechanical properties of a previously developed acellular porcine superflexor tendon (pSFT) were investigated. Irradiation following treatment with peracetic acid was compared to peracetic acid treatment alone and the stability of grafts following long-term storage assessed...
September 23, 2016: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/27659083/assessment-of-correlation-between-clinical-parameters-and-pulp-canal-pathogens-in-endodontic-pathologies-a-microbiological-study
#14
Vinisha Pandey, Isha Choudhary, Vipin Kumar, Prashant Tripathi, Abhinav Misra, Hiroj Bagde
INTRODUCTION: Success and failure of root canal therapy is largely dependent on the clinician and the patient. Once the tooth is restored into its functional and esthetic place, the root canal therapy is considered to be complete. It is a well-known fact that root canal space acts as a rich reservoir for microorganisms. Past studies show that root canal harbors an array of different microorganisms. Streptococcus mitis and Enterococcus faecalis have been found to be the most prevalent microorganisms isolated from the infected pulp canal space...
August 1, 2016: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/27612793/mechanical-and-antibacterial-properties-of-a-nanocellulose-polypyrrole-multilayer-composite
#15
Benoit Bideau, Julien Bras, Seema Saini, Claude Daneault, Eric Loranger
In this study, a composite film based on TEMPO-oxidized cellulose nanofibers (TOCN), polyvinyl alcohol (PVA) and polypyrrole (PPy) was synthesized in situ by a chemical polymerization, resulting in the induced absorption of PPy on the surface of the TOCN. The composite films were investigated with scanning electron microscopy, thermogravimetric analysis, contact angle measurements, mechanical tests, and evaluation of antibacterial properties. The developed composite has nearly identical Young modulus (3.4GPa), elongation (2...
December 1, 2016: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27608978/effect-of-provision-of-an-integrated-neonatal-survival-kit-and-early-cognitive-stimulation-package-by-community-health-workers-on-developmental-outcomes-of-infants-in-kwale-county-kenya-study-protocol-for-a-cluster-randomized-trial
#16
Lisa G Pell, Diego G Bassani, Lucy Nyaga, Isaac Njagi, Catherine Wanjiku, Thulasi Thiruchselvam, William Macharia, Ripudaman S Minhas, Patricia Kitsao-Wekulo, Amyn Lakhani, Zulfiqar A Bhutta, Robert Armstrong, Shaun K Morris
BACKGROUND: Each year, more than 200 million children under the age of 5 years, almost all in low- and middle-income countries (LMICs), fail to achieve their developmental potential. Risk factors for compromised development often coexist and include inadequate cognitive stimulation, poverty, nutritional deficiencies, infection and complications of being born low birthweight and/or premature. Moreover, many of these risk factors are closely associated with newborn morbidity and mortality...
September 8, 2016: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/27589973/parylene-mems-patency-sensor-for-assessment-of-hydrocephalus-shunt-obstruction
#17
Brian J Kim, Willa Jin, Alexander Baldwin, Lawrence Yu, Eisha Christian, Mark D Krieger, J Gordon McComb, Ellis Meng
Neurosurgical ventricular shunts inserted to treat hydrocephalus experience a cumulative failure rate of 80 % over 12 years; obstruction is responsible for most failures with a majority occurring at the proximal catheter. Current diagnosis of shunt malfunction is imprecise and involves neuroimaging studies and shunt tapping, an invasive measurement of intracranial pressure and shunt patency. These patients often present emergently and a delay in care has dire consequences. A microelectromechanical systems (MEMS) patency sensor was developed to enable direct and quantitative tracking of shunt patency in order to detect proximal shunt occlusion prior to the development of clinical symptoms thereby avoiding delays in treatment...
October 2016: Biomedical Microdevices
https://www.readbyqxmd.com/read/27570992/microbiological-quality-of-pediatric-oral-liquid-formulations
#18
Maria Josep Cabañas Poy, Carme Cañete Ramírez, Sabina X González di Lauro, Virginia Rodríguez Garrido, Gloria Roig Carbajosa, Aurora Fernández-Polo, Susana Clemente Bautista
The oral administration of drugs to the pediatric population involves the extemporaneous preparation of liquid formulations. These formulations have studies on their physicochemical stability, but they often lack microbiological studies. The objective of this study is to check the microbiological quality of five oral liquid formulations prepared with different excipients, which represent five major combinations, in two conditions: kept unopened until the day of the test, and in a multi-dose vial opened daily...
September 1, 2016: Farmacia Hospitalaria
https://www.readbyqxmd.com/read/27512653/does-the-urinary-microbiome-play-a-role-in-urgency-urinary-incontinence-and-its-severity
#19
Lisa Karstens, Mark Asquith, Sean Davin, Patrick Stauffer, Damien Fair, W Thomas Gregory, James T Rosenbaum, Shannon K McWeeney, Rahel Nardos
OBJECTIVES: Traditionally, the urinary tract has been thought to be sterile in the absence of a clinically identifiable infection. However, recent evidence suggests that the urinary tract harbors a variety of bacterial species, known collectively as the urinary microbiome, even when clinical cultures are negative. Whether these bacteria promote urinary health or contribute to urinary tract disease remains unknown. Emerging evidence indicates that a shift in the urinary microbiome may play an important role in urgency urinary incontinence (UUI)...
2016: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/27504341/differences-in-bacterial-colonization-and-biofilm-formation-property-of-uropathogens-between-the-two-most-commonly-used-indwelling-urinary-catheters
#20
Amit Verma, Deepa Bhani, Vinay Tomar, Rekha Bachhiwal, Shersingh Yadav
INTRODUCTION: Catheter Associated Urinary Tract Infections (CAUTI) are one of the most common cause of nosocomial infections. Many bacterial species show biofilm production, which provides survival benefit to them by providing protection from environmental stresses and causing decreased susceptibility to antimicrobial agents. Two most common types of catheters used in our setup are pure silicone catheter and silicone coated latex catheter. The advantage of pure silicone catheter for long term catheterization is well established...
June 2016: Journal of Clinical and Diagnostic Research: JCDR
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