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Sterile packaging

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https://www.readbyqxmd.com/read/28377648/comparison-of-antimicrobial-efficacy-of-diode-laser-triphala-and-sodium-hypochlorite-in-primary-root-canals-a-randomized-controlled-trial
#1
Seby Thomas, Sharath Asokan, Baby John, Geetha Priya, S Kumar
AIM: To evaluate the antimicrobial efficacy of diode laser, triphala, and sodium hypochlorite (NaOCl) against Enterococc-cus faecalis contaminated primary root canals. MATERIALS AND METHODS: Forty-nine single-rooted human primary teeth were reduced up to cemento-enamel junction and biomechanically prepared. After sterilization, five teeth were selected as negative controls and remaining teeth were inoculated with E. faecalis. The teeth were then randomly divided into four groups...
January 2017: International Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/28339392/stability-of-ribavirin-for-inhalation-packaged-in-syringes-or-glass-vials-when-stored-frozen-refrigerated-and-at-room-temperature
#2
Bayli Larson, Lane R Bushman, Matthew L Casciano, Alan R Oldland, Jennifer J Kiser, Tyree H Kiser
The primary aim of this study was to investigate ribavirin solution for inhalation stability under three different conditions (frozen, refrigerated, room temperature) over a 45-day period. A ribavirin 6000-mg vial was reconstituted with 90 mL of Sterile Water for Injection per the package insert to yield a concentration of approximately 67 mg/mL. The solution was then placed in either syringes or empty glass vials and stored in the freezer (-20°C), in the refrigerator (~0°C to 4°C), or at room temperature (~20°C to 25°C)...
November 2016: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/28336072/microneedle-enzyme-sensor-arrays-for-continuous-in-vivo-monitoring
#3
Anthony E G Cass, Sanjiv Sharma
Microneedle enzyme sensors by virtue of their minimally invasive and hence pain-free penetration of skin allow for the measurement of metabolites, biomarkers, and drugs in the interstitial fluid that bathes the dermal tissue. Such devices if they are to be adopted widely into clinical practice need to be capable of delivering reliable measurements over extended periods of time (days) and to be fabricated by low-cost, scalable methods. Using injection molding of the base structures in polycarbonate, metal film deposition by sputtering and enzyme immobilization by electrodeposition can meet these requirements...
2017: Methods in Enzymology
https://www.readbyqxmd.com/read/28333657/current-perspectives-on-the-syringe-delivery-system
#4
Michael J Akers
An article on the topic of sterile product packaging and delivery systems was published in the November/December 2015 issue of the International Journal of Pharmaceutical Compounding. This article expands the discussion on the syringe packaging system and provides more detail about the history, changes, challenges, and use of syringes in the compounding pharmacy.
May 2016: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/28331535/rosettr-protocol-and-software-for-seedling-area-and-growth-analysis
#5
Filipa Tomé, Karel Jansseune, Bernadette Saey, Jack Grundy, Korneel Vandenbroucke, Matthew A Hannah, Henning Redestig
BACKGROUND: Growth is an important parameter to consider when studying the impact of treatments or mutations on plant physiology. Leaf area and growth rates can be estimated efficiently from images of plants, but the experiment setup, image analysis, and statistical evaluation can be laborious, often requiring substantial manual effort and programming skills. RESULTS: Here we present rosettR, a non-destructive and high-throughput phenotyping protocol for the measurement of total rosette area of seedlings grown in plates in sterile conditions...
2017: Plant Methods
https://www.readbyqxmd.com/read/28271926/listeria-monocytogenes-internalizes-in-romaine-lettuce-grown-in-greenhouse-conditions
#6
Archana G Shenoy, Haley F Oliver, Amanda J Deering
Listeria monocytogenes has been implicated in a number of outbreaks involving fresh produce, including an outbreak in 2016 resulting from contaminated packaged salads. The persistence and internalization potential of L. monocytogenes in romaine lettuce was evaluated, and the persistence of two L. monocytogenes strains was assessed on three romaine lettuce cultivars. Seeds were germinated, and plants grown in three soil types (i.e., standard potting mix, autoclaved potting mix, and top soil) and sterile soft-top agar for up to 21 days...
March 8, 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/28184276/segregation-for-reduction-of-regulated-medical-waste-in-the-operating-room-a-case-report
#7
Helen Ki Shinn, Youngyoen Hwang, Byung-Gun Kim, Chunwoo Yang, WonJu Na, Jang-Ho Song, Hyun Kyoung Lim
One-third of all hospital-regulated medical waste (RMW) comes from the operating room (OR), and it considerably consists of disposable packaging and wrapping materials for the sterilization of surgical instruments. This study sought to identify the amount and type of waste produced by ORs in order to reduce the RMW so as to achieve environmentally-friendly waste management in the OR. We performed an initial waste segregation of 4 total knee replacement arthroplasties (TKRAs) and 1 total hip replacement arthroplasty, and later of 1 extra TKRA, 1 laparoscopic anterior resection of the colon, and 1 pelviscopy (with radical vaginal hysterectomy), performed at our OR...
February 2017: Korean Journal of Anesthesiology
https://www.readbyqxmd.com/read/28163377/destruction-of-biological-particles-using-non-thermal-plasma
#8
REVIEW
Akira Mizuno
Mechanism of inactivation of bio-particles exposed to non-thermal plasma (NTP), namely, dielectric barrier discharge (DBD), and plasma jet (PJ), has been studied using E. coli, B. subtilis spore, S. cerevisiae and bacteriophages. States of different biological components were monitored during the course of inactivation. Analysis of green fluorescent protein, GFP, introduced into E. coli. or B. subtiles spore cells proved that radicals generated by NTP penetrate into microbes, destroying the cell membrane and finally damage the genes...
January 2017: Journal of Clinical Biochemistry and Nutrition
https://www.readbyqxmd.com/read/28119764/relevant-in-vitro-predictors-of-human-acellular-dermal-matrix-associated-inflammation-and-capsule-formation-in-a-nonhuman-primate-subcutaneous-tissue-expander-model
#9
Maryellen Sandor, Patrick Leamy, Pearl Assan, Amardeep Hoonjan, Li-Ting Huang, Marianne Edwards, Wenqi Zuo, Hui Li, Hui Xu
Objective: Benchtop methods were evaluated for preclinical inflammation/capsule formation correlation following implantation of human acellular dermal matrices. Methods: Dermal matrices were compared with native dermis for structure (histology, scanning electron microscopy), collagen solubility (hydroxyproline), enzymatic susceptibility (collagenase), and thermal stability (differential scanning calorimetry). Results were compared with implantation outcomes in a primate tissue expander model. Results: Native dermis, electron beam-sterilized, and freeze-dried human acellular dermal matrices had equivalent morphology, acid-soluble collagen (60...
2017: Eplasty
https://www.readbyqxmd.com/read/28118825/optimization-of-mosquito-egg-production-under-mass-rearing-setting-effects-of-cage-volume-blood-meal-source-and-adult-population-density-for-the-malaria-vector-anopheles-arabiensis
#10
Wadaka Mamai, Nanwintoum S Bimbile-Somda, Hamidou Maiga, José Guillermo Juarez, Zaynab A I Muosa, Adel Barakat Ali, Rosemary Susan Lees, Jeremie R L Gilles
BACKGROUND: Anopheles arabiensis is one of the major malaria vectors that put millions of people in endemic countries at risk. Mass-rearing of this mosquito is crucial for strategies that use sterile insect technique to suppress vector populations. The sterile insect technique (SIT) package for this mosquito species is being developed by the Insect Pest Control Subprogramme of the Joint FAO/IAEA Division of Nuclear Techniques in Food and Agriculture. To improve mass-rearing outcomes for An...
January 24, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28113914/system-on-chip-considerations-for-heterogeneous-integration-of-cmos-and-fluidic-bio-interfaces
#11
Timir Datta-Chaudhuri, Elisabeth Smela, Pamela A Abshire
CMOS chips are increasingly used for direct sensing and interfacing with fluidic and biological systems. While many biosensing systems have successfully combined CMOS chips for readout and signal processing with passive sensing arrays, systems that co-locate sensing with active circuits on a single chip offer significant advantages in size and performance but increase the complexity of multi-domain design and heterogeneous integration. This emerging class of lab-on-CMOS systems also poses distinct and vexing technical challenges that arise from the disparate requirements of biosensors and integrated circuits (ICs)...
April 21, 2016: IEEE Transactions on Biomedical Circuits and Systems
https://www.readbyqxmd.com/read/28055826/system-on-chip-considerations-for-heterogeneous-integration-of-cmos-and-fluidic-bio-interfaces
#12
Timir Datta-Chaudhuri, Elisabeth Smela, Pamela A Abshire
CMOS chips are increasingly used for direct sensing and interfacing with fluidic and biological systems. While many biosensing systems have successfully combined CMOS chips for readout and signal processing with passive sensing arrays, systems that co-locate sensing with active circuits on a single chip offer significant advantages in size and performance but increase the complexity of multi-domain design and heterogeneous integration. This emerging class of lab-on-CMOS systems also poses distinct and vexing technical challenges that arise from the disparate requirements of biosensors and integrated circuits (ICs)...
December 2016: IEEE Transactions on Biomedical Circuits and Systems
https://www.readbyqxmd.com/read/27927920/validation-of-autoclave-protocols-for-successful-decontamination-of-category-a-medical-waste-generated-from-care-of-patients-with-serious-communicable-diseases
#13
Brian T Garibaldi, Mallory Reimers, Neysa Ernst, Gregory Bova, Elaine Nowakowski, James Bukowski, Brandon C Ellis, Chris Smith, Lauren Sauer, Kim Dionne, Karen C Carroll, Lisa L Maragakis, Nicole M Parrish
In response to the Ebola outbreak in 2014, many hospitals designated specific areas to care for patients with Ebola and other highly infectious diseases. The safe handling of category A infectious substances is a unique challenge in this environment. One solution is on-site waste treatment with a steam sterilizer or autoclave. The Johns Hopkins Hospital (JHH) installed two pass-through autoclaves in its biocontainment unit (BCU). The JHH BCU and The Johns Hopkins biosafety level 3 (BSL-3) clinical microbiology laboratory designed and validated waste-handling protocols with simulated patient trash to ensure adequate sterilization...
February 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/27884664/bacterial-contamination-of-saline-used-for-epidural-procedures-in-an-obstetric-setting-a-randomised-comparison-of-two-drawing-up-techniques
#14
M Onofrei, M Y Wee, B Parker, N Wee, S Hill
BACKGROUND: There is little evidence to inform practice regarding the optimum aseptic technique of drawing up saline for epidural insertion. Our regional practice is to draw up saline from a non-sterile packaged plastic ampoule, therefore introducing the risk of bacterial contamination. Usually, the anaesthetist draws up saline directly from the vial held by an assistant using a needle (needle technique). Alternatively, the saline vial is emptied onto a sterile tray by an assistant and then drawn up by the anaesthetist (tray technique)...
February 2017: International Journal of Obstetric Anesthesia
https://www.readbyqxmd.com/read/27843253/acidogenic-potential-of-plain-milk-milk-with-sugar-milk-with-cornflakes-and-milk-cornflakes-with-sugar-a-comparative-study
#15
REVIEW
Sham S Bhat, Sundeep K Hegde, Vidya S Bhat, K M Ramya, Praveen S Jodalli
AIM: To compare the acidogenic potential of plain milk, milk with sugar, milk with cornflakes, and milk cornflakes with sugar by assessing the salivary pH. MATERIALS AND METHODS: The study was carried out on 40 school children of 8 to 12 years; 20 boys and 20 girls were randomly selected. The salivary pH was assessed before and after the consumption of milk; milk and sugar; milk and cornflakes; and milk, sugar, and cornflakes. Baseline unstimulated saliva was collected in sterile plastic tube and the pH was recorded...
July 2016: International Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/27789803/container-closure-integrity-testing-practical-aspects-and-approaches-in-the-pharmaceutical-industry
#16
Helen Brown, Hanns-Christian Mahler, James Mellman, Alejandra Nieto, Daniel Wagner, Matthias Schaar, Roman Mathaes, Juergen Kossinna, Franz Schmitting, Sascha Dreher, Holger Roehl, Markus Hemminger, Klaus Wuchner
The assurance of sterility of a parenteral drug product, prior to any human use, is a regulatory requirement. Hence, all strategies related to container closure integrity (CCI) must demonstrate absence of microbial contamination through leaks as part of the container closure system (CCS) qualification, during manufacturing, for Quality Control purposes and to ensure microbiological integrity (sterility) during storage and shipment up to the end of product shelf life. Current regulatory guidances, which differ between countries and regions, provide limited detail on how to assess CCI...
October 27, 2016: PDA Journal of Pharmaceutical Science and Technology
https://www.readbyqxmd.com/read/27773471/can-the-design-of-glove-dispensing-boxes-influence-glove-contamination
#17
O Assadian, D J Leaper, A Kramer, K J Ousey
BACKGROUND: Few studies have explored the microbial contamination of glove boxes in clinical settings. The objective of this observational study was to investigate whether a new glove packaging system in which single gloves are dispensed vertically, cuff end first, has lower levels of contamination on the gloves and on the surface around the box aperture compared with conventional glove boxes. METHODS: Seven participating sites were provided with vertical glove dispensing systems (modified boxes) and conventional boxes...
November 2016: Journal of Hospital Infection
https://www.readbyqxmd.com/read/27717732/evidence-that-the-endometrial-microbiota-has-an-effect-on-implantation-success-or-failure
#18
Inmaculada Moreno, Francisco M Codoñer, Felipe Vilella, Diana Valbuena, Juan F Martinez-Blanch, Jorge Jimenez-Almazán, Roberto Alonso, Pilar Alamá, Jose Remohí, Antonio Pellicer, Daniel Ramon, Carlos Simon
BACKGROUND: Bacterial cells in the human body account for 1-3% of total body weight and are at least equal in number to human cells. Recent research has focused on understanding how the different bacterial communities in the body (eg, gut, respiratory, skin, and vaginal microbiomes) predispose to health and disease. The microbiota of the reproductive tract has been inferred from the vaginal bacterial communities, and the uterus has been classically considered a sterile cavity. However, while the vaginal microbiota has been investigated in depth, there is a paucity of consistent data regarding the existence of an endometrial microbiota and its possible impact in reproductive function...
December 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27662636/the-effects-of-irradiation-on-the-biological-and-biomechanical-properties-of-an-acellular-porcine-superflexor-tendon-graft-for-cruciate-ligament-repair
#19
Jennifer H Edwards, Anthony Herbert, Gemma L Jones, Iain W Manfield, John Fisher, Eileen Ingham
Acellular xenogeneic tissues have the potential to provide 'off-the-shelf' grafts for anterior cruciate ligament (ACL) repair. To ensure that such grafts are sterile following packaging, it is desirable to use terminal sterilization methods. Here, the effects of gamma and electron beam irradiation on the biological and biomechanical properties of a previously developed acellular porcine superflexor tendon (pSFT) were investigated. Irradiation following treatment with peracetic acid was compared to peracetic acid treatment alone and the stability of grafts following long-term storage assessed...
September 23, 2016: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/27659083/assessment-of-correlation-between-clinical-parameters-and-pulp-canal-pathogens-in-endodontic-pathologies-a-microbiological-study
#20
Vinisha Pandey, Isha Choudhary, Vipin Kumar, Prashant Tripathi, Abhinav Misra, Hiroj Bagde
INTRODUCTION: Success and failure of root canal therapy is largely dependent on the clinician and the patient. Once the tooth is restored into its functional and esthetic place, the root canal therapy is considered to be complete. It is a well-known fact that root canal space acts as a rich reservoir for microorganisms. Past studies show that root canal harbors an array of different microorganisms. Streptococcus mitis and Enterococcus faecalis have been found to be the most prevalent microorganisms isolated from the infected pulp canal space...
August 1, 2016: Journal of Contemporary Dental Practice
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