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https://www.readbyqxmd.com/read/28898722/influence-of-gamma-and-electron-beam-sterilization-on-the-stability-of-a-premixed-injectable-calcium-phosphate-cement-for-trauma-indications
#1
Kieran A Murray, Maurice N Collins, Regina P O'Sullivan, Guang Ren, Declan M Devine, Alan Murphy, Jarosław Sadło, Carol O'Sullivan, Brian McEvoy, Olivier Vrain, Cathriona O'Neill, Gerard Insley
Premixed calcium phosphate cements (CPC's) are becoming the material of choice for injectable cements as a result of their effective delivery to the target implantation site. For orthopaedic use, it is of vital importance that the attributes of these CPC's are not compromised by irradiation sterilization. Therefore, the aim of this study is to determine the influence of irradiation sterilization on a range of premixed CPC's, with an emphasis on improving product shelf life through the use of optimal packaging configurations and annealing steps...
September 5, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28894161/microbial-communities-in-placentas-from-term-normal-pregnancy-exhibit-spatially-variable-profiles
#2
Lindsay A Parnell, Catherine M Briggs, Bin Cao, Omar Delannoy-Bruno, Andrew E Schrieffer, Indira U Mysorekar
The placenta is the principal organ nurturing the fetus during pregnancy and was traditionally considered to be sterile. Recent work has suggested that the placenta harbours microbial communities, however the location and possible function of these microbes remain to be confirmed and elucidated. Here, we employed genomic DNA sequencing of multiple variable (V) regions of the bacterial 16S ribosomal gene, to interrogate microbial profiles in term pregnancies, from the basal plate, which is in direct contact with maternal uterine, endothelial, and immune cells; placental villi, which are bathed in maternal blood, and fetal membranes, which encapsulate the amniotic cavity...
September 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28893036/oral-candidal-carriage-in-subjects-with-pure-vegetarian-and-mixed-dietary-habits
#3
Shankargouda Patil, Roopa S Rao, A Thirumal Raj, D S Sanketh, Sachin Sarode, Gargi Sarode
INTRODUCTION: Candida albicans being a part of the normal oral microbial flora is one of the most commonly isolated species from the oral cavity. Recent studies have shown a steady rise in the number of non C. albicans species, which are relatively resistant to common antifungal agents and are being recognized as potential pathogens. It is vital to ascertain the predisposing factors leading to such a shift in the oral candidal flora. AIM: To estimate the prevalence of candidal species among vegetarians and non-vegetarians...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28858636/damage-associated-molecular-pattern-markers-hmgb1-and-cell-free-fetal-telomere-fragments-in-oxidative-stressed-amnion-epithelial-cell-derived-exosomes
#4
Samantha Sheller-Miller, Rheanna Urrabaz-Garza, George Saade, Ramkumar Menon
Term labor in humans is associated with increased oxidative stress (OS) -induced senescence and damages to amnion epithelial cells (AECs). Senescent fetal cells release alarmin high-mobility group box 1 (HMGB1) and cell-free fetal telomere fragments (cffTF) which can be carried by exosomes to other uterine tissues to produce parturition-associated inflammatory changes. This study characterized AEC-derived exosomes under normal and OS conditions and their packaging of HMGB1 and cffTF. Primary AECs were treated with either standard media or oxidative stress-induced media (exposure to cigarette smoke extract for 48h)...
August 24, 2017: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/28819049/a-comparison-of-protein-stability-in-prefillable-syringes-made-of-glass-and-plastic
#5
Lloyd Waxman, Vinod D Vilivalam
The development of protein therapeutics requires stabilization of these labile molecules during shipment and storage. Biologics, particularly monoclonal antibodies, are frequently packaged at high concentration in prefillable syringes traditionally made of glass. However, some biologics are unstable in glass due to sensitivity to silicone oil, tungsten, glue or metal ions. Syringes made from the plastic cyclic olefin polymer, Daikyo Crystal Zenith® (CZ), with a Flurotec-laminated piston have none of these issues...
August 17, 2017: PDA Journal of Pharmaceutical Science and Technology
https://www.readbyqxmd.com/read/28799106/chemical-sterilization-of-allograft-dermal-tissues
#6
Abigail Phipps, Edward Vaynshteyn, John B Kowalski, Manh-Dan Ngo, Karen Merritt, Joel Osborne, Evangelia Chnari
Common terminal sterilization methods are known to alter the natural structure and properties of soft tissues. One approach to providing safe grafts with preserved biological properties is the combination of a validated chemical sterilization process followed by an aseptic packaging process. This combination of processes is an accepted method for production of sterile healthcare products as described in ANSI/AAMI ST67:2011. This article describes the validation of the peracetic acid and ethanol-based (PAAE) chemical sterilization process for allograft dermal tissues at the Musculoskeletal Transplant Foundation (MTF, Edison, NJ)...
August 10, 2017: Cell and Tissue Banking
https://www.readbyqxmd.com/read/28757084/outbreak-of-health-care-associated-burkholderia-cenocepacia-bacteremia-and-infection-attributed-to-contaminated-sterile-gel-used-for-central-line-insertion-under-ultrasound-guidance-and-other-procedures
#7
Ramon Z Shaban, Samuel Maloney, John Gerrard, Peter Collignon, Deborough Macbeth, Marilyn Cruickshank, Anna Hume, Amy V Jennison, Rikki M A Graham, Haakon Bergh, Heather L Wilson, Petra Derrington
BACKGROUND: We report an outbreak of Burkholderia cenocepacia bacteremia and infection in 11 patients predominately in intensive care units caused by contaminated ultrasound gel used in central line insertion and sterile procedures within 4 hospitals across Australia. METHODS: Burkholderia cenocepacia was first identified in the blood culture of a patient from the intensive care unit at the Gold Coast University Hospital on March 26, 2017, with 3 subsequent cases identified by April 7, 2017...
July 27, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28687186/evaluation-of-a-new-packaging-process-for-non-autoclavable-endoscopes-results-for-the-first%C3%A2-100%C3%A2-microbiological-samples
#8
C Minebois, P Saviuc, J Shum, P Tuvignon, I Pelloux, M-P Brenier-Pinchart, C Landelle, M-R Mallaret
BACKGROUND: A new process for packaging endoscopes (SureStore(®), Medical Innovations Group) immediately after they exit from washing and disinfection in an automated endoscope reprocessor (AER) allows for endoscopes to be stored for up to 15 days. AIM: To describe the microbiological quality of samples from gastrointestinal endoscopes following this process. METHODS: Three-month prospective study using microbiological sampling from a stock of 38 gastrointestinal endoscopes carried out in a French University Hospital...
July 4, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/28647423/effect-of-hand-hygiene-and-glove-use-on-cleanliness-of-reusable-surgical-instruments
#9
D M Costa, L K O Lopes, A F V Tipple, R B Castillo, H Hu, A K Deva, K Vickery
BACKGROUND: During functionality testing and packaging of reusable surgical instruments (RSI) for sterilization, instruments are frequently touched. There is a lack of standards relating to hand hygiene frequency and use of gloves in the sterilizing service unit packing area. AIM: To determine the effect of hand hygiene and glove use on maintenance of RSI cleanliness. METHODS: Following manual and automated cleaning, Halsted-mosquito forceps were assessed for adenosine triphosphate (ATP), protein and microbial contamination after handling with gloved and ungloved but washed hands using an ATP surface swab test, bicinchoninic acid assay, and standard culture plate/broth, respectively...
June 21, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/28616079/surgical-site-infection-and-its-associated-factors-following-cesarean-section-a-cross-sectional-study-from-a-public-hospital-in-ethiopia
#10
Kelemu Abebe Gelaw, Amlaku Mulat Aweke, Feleke Hailemichael Astawesegn, Birhanu Wondimeneh Demissie, Liknaw Bewket Zeleke
BACKGROUND: A cesarean section is a surgical procedure in which incisions are made through a woman's abdomen and uterus to deliver her baby. Surgical site infections are a common surgical complication among patients delivered with cesarean section. Further it caused to increase maternal morbidity, stay of hospital and the cost of treatment. METHODS: Hospital based cross-sectional study was conducted to assess the magnitude of surgical site infection following cesarean Site Infections and its associated factors at Lemlem Karl hospital July 1, 2013 to June 30, 2016...
2017: Patient Safety in Surgery
https://www.readbyqxmd.com/read/28577503/ph-triggered-controlled-drug-delivery-from-contact-lenses-addressing-the-challenges-of-drug-leaching-during-sterilization-and-storage
#11
Furqan A Maulvi, Harsh H Choksi, Ankita R Desai, Akanksha S Patel, Ketan M Ranch, Bhavin A Vyas, Dinesh O Shah
In the present work a novel cyclosporine-loaded Eudragit S100 (pH-sensitive) nanoparticles-laden contact lenses were designed to provide sustained release of cyclosporine at therapeutic rates, without leaching of drug during sterilization and storage period (shelf life). The nanoparticles were prepared by Quasi-emulsion solvent diffusion technique using different weight ratios of cyclosporine to Eudragit S100. The contact lenses with direct drug entrapment were also fabricated (DL-50) for comparison. The percentage swelling and optical transparency of nanoparticles-laden contact lenses were improved in comparison to DL-50 lenses...
September 1, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28571138/bacterial-contamination-of-adult-house-flies-musca-domestica-and-sensitivity-of-these-bacteria-to-various-antibiotics-captured-from-hamadan-city-iran
#12
Mansour Nazari, Tahereh Mehrabi, Seyed Mostafa Hosseini, Mohammad Yousef Alikhani
INTRODUCTION: House flies (Musca domestica) have been known as a mechanical vector in spreading infectious diseases such as cholera, shigellosis, salmonellosis and skin infections. AIM: To investigate the bacterial contaminations of house flies and determine the resistance of these bacteria against various antibiotics. MATERIALS AND METHODS: An analytical descriptive cross- sectional study was conducted. The study was performed from July to September 2015 in Hamadan University of Medical Sciences, Hamadan, Iran...
April 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28511502/comparative-evaluation-of-three-herbal-solutions-on-the-disinfection-of-guttapercha-cones-an-in-vitro-study
#13
Pratap Kumar Mukka, Samba Shiva Rao Pola, Nanda Kumar Kommineni, Mayuri Sailaja Pachalla, Anand Ramtheerth Karne, Karthik Labishetty, Supriya Kommineni, Praveen Chilakabathini
INTRODUCTION: Guttapercha (GP) cones are usually supplied in aseptic, sealed packages from the manufacturers, but once exposed to the dental office environment or even by handling; they can be contaminated by a number of microorganisms. Supplementary decontamination of GP cones is critical. As they cannot be sterilized by moist or dry heat, cold sterilization, using disinfectants should be used. AIM: The aim of the study was to evaluate rapid, reliable, convenient and effective method of disinfection of GP cones using readily available herbal solutions such as Aloevera Juice, Amla Juice and Pancha Tulsi...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28504125/preparation-of-chitosan-tio2-composite-film-with-efficient-antimicrobial-activities-under-visible-light-for-food-packaging-applications
#14
Xiaodong Zhang, Gang Xiao, Yaoqiang Wang, Yan Zhao, Haijia Su, Tianwei Tan
By incorporation of TiO2 nano-powder in chitosan, a chitosan-TiO2 composite film was prepared with efficient antimicrobial activity against food-borne pathogenic microbes and expected to be a promising food packaging material. Scanning electron microscopy analysis showed that the TiO2 nano-powder was successfully and uniformly dispersed into the chitosan matrix. TiO2 addition led to enhanced hydrophilicity, to better mechanical properties, and to decreased light transmittance in visible light region of the composite film...
August 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28500861/overview-of-high-risk-medical-device-recalls-in%C3%A2-obstetrics%C3%A2-and-gynecology-from-2002-through-2016-%C3%A2-implications-for-device-safety
#15
Timothy M Janetos, Comeron W Ghobadi, Shuai Xu, Jessica R Walter
The field of women's health has endured numerous recent controversies involving medical devices such as pelvic meshes, laparoscopic morcellators, and a hysteroscopic sterilization device. With the recent passage of the 21st Century Cures Act, new legislation will change how the Food and Drug Administration regulates medical devices. Given these controversies and new changes, we investigated high-risk, class I recalls in women's health from 2002 through 2016. Class I recalls for medical devices are defined by the Food and Drug Administration as the most serious recall events and are designated for situations when there is a reasonable probability of serious adverse health consequences or death...
July 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28475151/antimicrobial-optical-and-mechanical-properties-of-chitosan-starch-films-with-natural-extracts
#16
Jessica I Lozano-Navarro, Nancy P Díaz-Zavala, Carlos Velasco-Santos, Ana L Martínez-Hernández, Beatriz I Tijerina-Ramos, Margarita García-Hernández, José L Rivera-Armenta, Ulises Páramo-García, Adriana I Reyes-de la Torre
Natural extracts possess several kinds of antioxidants (anthocyanins, betalains, thymol, carvacrol, and resveratrol) that have also demonstrated antimicrobial properties. In order to study these properties, extracts from cranberry, blueberry, beetroot, pomegranate, oregano, pitaya, and resveratrol (from grapes) were obtained. Growth inhibition tests of mesophilic aerobes, coliforms, and fungi were conducted in films prepared from the extracts in accordance with Mexican Official Norms (NOM). Optical properties such as transparency and opacity, mechanical properties, and pH were also analyzed in these materials...
May 5, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28471056/essential-oil-bioactive-fibrous-membranes-prepared-via-coaxial-electrospinning
#17
Zhi-Cheng Yao, Si-Cong Chen, Zeeshan Ahmad, Jie Huang, Ming-Wei Chang, Jing-Song Li
A novel antimicrobial composite material was prepared by encapsulating orange essential oil (OEO) in zein prolamine (ZP) via the coaxial electrospinning (ES) technique. By manipulating process parameters, the morphological features of ZP/OEO fibers were modulated. Fine fibers with diameters ranging from 0.7 to 2.3 μm were obtained by regulating ZP solution concentration and process parameters during the ES process. Optimal loading capacity (LC) and encapsulation efficiency (EE) of OEO in fibrous ZP mats were determined to be 22...
June 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28447477/simultaneous-visualization-of-hydrogen-peroxide-and-water-concentrations-using-photofragmentation-laser-induced-fluorescence
#18
Kajsa Larsson, Marcus Aldén, Joakim Bood
A concept based on photofragmentation laser-induced fluorescence (PFLIF) is for the first time demonstrated for simultaneous detection of hydrogen peroxide (H2O2) and water (H2O) vapor in various mixtures containing the two constituents in a bath of argon gas. A photolysis laser pulse at 248 nm dissociates H2O2 into OH fragments, whereupon a probe pulse, delayed 100 ns and tuned to an absorption line in the A(2)Σ(+) (v = 1) ← X(2)Π(v = 0) band of OH near 282 nm, induces fluorescence. The total OH fluorescence reflects the H2O2 concentration, while its spectral shape is utilized to determine the H2O concentration via a model predicting the ratio between the fluorescence intensities of the A(2)Σ(+) (v = 1) → X(2)Π(v = 1) and the A(2)Σ(+) (v = 0) → X(2)Π(v = 0) bands...
January 1, 2017: Applied Spectroscopy
https://www.readbyqxmd.com/read/28377648/comparison-of-antimicrobial-efficacy-of-diode-laser-triphala-and-sodium-hypochlorite-in-primary-root-canals-a-randomized-controlled-trial
#19
Seby Thomas, Sharath Asokan, Baby John, Geetha Priya, S Kumar
AIM: To evaluate the antimicrobial efficacy of diode laser, triphala, and sodium hypochlorite (NaOCl) against Enterococc-cus faecalis contaminated primary root canals. MATERIALS AND METHODS: Forty-nine single-rooted human primary teeth were reduced up to cemento-enamel junction and biomechanically prepared. After sterilization, five teeth were selected as negative controls and remaining teeth were inoculated with E. faecalis. The teeth were then randomly divided into four groups...
January 2017: International Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/28339392/stability-of-ribavirin-for-inhalation-packaged-in-syringes-or-glass-vials-when-stored-frozen-refrigerated-and-at-room-temperature
#20
COMPARATIVE STUDY
Bayli Larson, Lane R Bushman, Matthew L Casciano, Alan R Oldland, Jennifer J Kiser, Tyree H Kiser
The primary aim of this study was to investigate ribavirin solution for inhalation stability under three different conditions (frozen, refrigerated, room temperature) over a 45-day period. A ribavirin 6000-mg vial was reconstituted with 90 mL of Sterile Water for Injection per the package insert to yield a concentration of approximately 67 mg/mL. The solution was then placed in either syringes or empty glass vials and stored in the freezer (-20°C), in the refrigerator (~0°C to 4°C), or at room temperature (~20°C to 25°C)...
November 2016: International Journal of Pharmaceutical Compounding
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