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Sterile barrier

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https://www.readbyqxmd.com/read/28436707/samhd1-protects-cancer-cells-from-various-nucleoside-based-antimetabolites
#1
Nikolas Herold, Sean G Rudd, Kumar Sanjiv, Juliane Kutzner, Julia Bladh, Cynthia B J Paulin, Thomas Helleday, J I Henter, Torsten Schaller
Recently, we demonstrated that sterile alpha motif and HD domain containing protein 1 (SAMHD1) is a major barrier in acute myelogenous leukemic (AML) cells to the cytotoxicity of cytarabine (ara-C), the most important drug in AML treatment. Ara-C is intracellularly converted by the canonical dNTP synthesis pathway to ara-CTP, which serves as a substrate but not an allosteric activator of SAMHD1. Using an AML mouse model, we show here that wild type but not catalytically inactive SAMHD1 reduces ara-C treatment efficacy in vivo...
April 24, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28432354/structural-and-functional-analysis-of-lysozyme-after-treatment-with-dielectric-barrier-discharge-plasma-and-atmospheric-pressure-plasma-jet
#2
Sooho Choi, Pankaj Attri, Inhwan Lee, Jeongmin Oh, Ji-Hye Yun, Ji Hoon Park, Eun Ha Choi, Weontae Lee
The variation in the biological function of proteins plays an important role in plasma medicine and sterilization. Several non-thermal plasma sources with different feeding gases are used worldwide for plasma treatment, including dielectric barrier discharge (DBD) and atmospheric-pressure plasma jet (APPJ) as the most commonly used sources. Therefore, in the present work, we used both DBD and APPJ plasma sources with N2 and air as feeding gases to evaluate the effects on the structural, thermodynamic, and activity changes of enzymes...
April 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28430013/barriers-to-access-to-sterile-syringes-as-perceived-by-pharmacists-and-injecting-drug-users-implications-for-harm-reduction-in-lebanon
#3
Ali Ghaddar, Karine Nassar, Ghadier Elsoury
BACKGROUND: Access to sterile syringes to injecting drug users (IDU) reduces sharing behavior and prevents the transmission of HIV. OBJECTIVES: To describe the barriers to access to sterile syringes for IDUs in Lebanon from the perspectives of pharmacists and IDUs. METHODS: in this qualitative study conducted in Lebanon, data were collected from 72 syringe purchase tests at pharmacies, 64 interviewees with pharmacists and 2 focus groups with injecting drug users...
April 21, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28429734/neuroprotective-pentapeptide-cn-105-is-associated-with-reduced-sterile-inflammation-and-improved-functional-outcomes-in-a-traumatic-brain-injury-murine-model
#4
Daniel T Laskowitz, Haichen Wang, Tony Chen, David T Lubkin, Viviana Cantillana, Tian Ming Tu, Dawn Kernagis, Guanen Zhou, Gary Macy, Bradley J Kolls, Hana N Dawson
At present, there are no proven pharmacological treatments demonstrated to improve long term functional outcomes following traumatic brain injury(TBI). In the setting of non-penetrating TBI, sterile brain inflammatory responses are associated with the development of cerebral edema, intracranial hypertension, and secondary neuronal injury. There is increasing evidence that endogenous apolipoprotein E(apoE) modifies the neuroinflammatory response through its role in downregulating glial activation, however, the intact apoE holoprotein does not cross the blood-brain barrier due to its size...
April 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28424873/the-changes-in-the-reproductive-barrier-between-hexaploid-wheat-triticum-aestivum-l-and-rye-secale-cereale-l-different-states-lead-to-different-fates
#5
Natalia Tikhenko, Twan Rutten, Angelika Senula, Myroslava Rubtsova, E R Joachim Keller, Andreas Börner
The changes in the reproductive barrier between hexaploid wheat ( Triticum aestivum L.) and rye ( Secale cereale L.) can be induced using in situ embryo rescue of abnormal embryos, yielding stable fertile amphidiploid plants. In intergeneric crosses between hexaploid wheat (Triticum aestivum L.) and rye (Secale cereale L.), postzygotic barriers may occur at different stages of hybrid development. One such mechanism is embryo lethality, which is genetically determined by the interaction and expression of two incompatible genes in wheat (Eml-A1) and rye (Eml-R1)...
April 19, 2017: Planta
https://www.readbyqxmd.com/read/28419180/impact-of-gestational-nicotine-exposure-on-intrauterine-and-fetal-infection-in-a-rodent-model1
#6
Maria von Chamier, Leticia Reyes, Linda F Hayward, Mary B Brown
We investigated the interaction between prenatal nicotine exposure and intrauterine infection using established rat models. Beginning at gestation day (GD) 6, dams were continuously infused with either saline or 6 mg/kg/day nicotine (Nic). At GD 14, dams received either sterile broth or 105 CFU Mycoplasma pulmonis (MP), resulting in 4 treatment groups: Control (4 dams, 33 fetal units); MP only (5 dams, 55 fetal units); Nic only (5 dams, 61 fetal units) and Nic + MP (7 dams, 82 fetal units). At GD 18, nicotine exposure significantly increased (P ≤ 0...
April 17, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/28401188/samhd1-is-a-barrier-to-antimetabolite-based-cancer-therapies
#7
Sean G Rudd, Torsten Schaller, Nikolas Herold
The outcome of acute myelogenous leukemia (AML) therapy depends on the propensity of leukemic blasts to accumulate ara-CTP, the active triphosphate of cytarabine (ara-C). We identified sterile α motif and HD domain-containing protein 1 (SAMHD1) as an ara-CTPase that protects cancer cells from cytarabine-induced toxicity. Therefore, we propose targeting SAMHD1 as a strategy to potentiate cytarabine and possibly other antimetabolite-based therapies.
2017: Molecular & Cellular Oncology
https://www.readbyqxmd.com/read/28396924/non-introgressive-genome-chimerisation-by-malsegregation-in-autodiploidised-allotetraploids-during-meiosis-of-saccharomyces-kudriavzevii-x-saccharomyces-uvarum-hybrids
#8
Edina Karanyicz, Zsuzsa Antunovics, Z Kallai, M Sipiczki
Saccharomyces strains with chimerical genomes consisting of mosaics of the genomes of different species ("natural hybrids") occur quite frequently among industrial and wine strains. The most widely endorsed hypothesis is that the mosaics are introgressions acquired via hybridisation and repeated backcrosses of the hybrids with one of the parental species. However, the interspecies hybrids are sterile, unable to mate with their parents. Here, we show by analysing synthetic Saccharomyces kudriavzevii x Saccharomyces uvarum hybrids that mosaic (chimeric) genomes can arise without introgressive backcrosses...
April 10, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28395956/benefit-of-an-implanted-solid-barrier-for-the-feasibility-of-a-sequence-of-three-different-hepato-biliary-operations-in-a-small-animal-model
#9
B Richter, C Sänger, F Mussbach, H Scheuerlein, U Settmacher, U Dahmen
BACKGROUND: Current liver surgery includes complex multi-stage procedures such as portal vein ligation (PVL) followed by extended liver resection, especially in patients with Klatskin tumours. The risk for severe adhesions increases with every procedure. Finally, this complex sequence could fail because of malignant adhesions. Therefore, we proved the hypothesis of reducing malignant adhesions and increasing feasibility of a sequence with three hepato-biliary operations by implantation of a solid barrier...
April 8, 2017: Journal of Visceral Surgery
https://www.readbyqxmd.com/read/28386497/bilateral-severe-sterile-inflammation-with-hypopyon-after-simultaneous-intravitreal-triamcinolone-acetonide-and-aflibercept-injection-in-a-patient-with-bilateral-marked-rubeosis-associated-with-ocular-ischemic-syndrome
#10
Ceren Durmaz Engin, Ziya Ayhan, Süleyman Men, Aylin Yaman, A Osman Saatci
We report the clinical course of a diabetic patient with bilateral cataract and rubeosis in association with ocular ischemic syndrome and initially treated him with simultaneous intravitreal 2 mg aflibercept and 2 mg triamcinolone acetonide injection at the same setting prior to planned cataract surgery and further photocoagulation. However, sterile anterior segment inflammation characterized by hypopyon occurred four days apart in OU. Right eye developed the sterile inflammation at the third postinjection day and the left eye developed the sterile inflammation at the seventh postinjection day (two days after the uneventful cataract surgery with intraocular lens implantation) without any pain or significant redness...
2017: Case Reports in Ophthalmological Medicine
https://www.readbyqxmd.com/read/28385588/outcomes-of-elective-outpatient-hysteroscopic-sterilization-in-undocumented-women-a-retrospective-analysis
#11
Patsy J McGuire, Jennifer Butler, Christina Gavito, Jeanelle Sheeder, Kristina Tocce
OBJECTIVE: To determine the feasibility of hysteroscopic sterilization in low-income and unauthorized immigrant women when financial barriers to care are removed. METHODS: Outpatient hysteroscopic sterilization for low-income women at an urban clinic was made possible by grant funding. All procedures were performed by obstetrician/gynecologist attending physicians or supervised trainees. Electronic records were reviewed for cases performed from June 2010 to December 11, 2013...
April 3, 2017: Women's Health Issues: Official Publication of the Jacobs Institute of Women's Health
https://www.readbyqxmd.com/read/28367153/pentaploid-wheat-hybrids-applications-characterisation-and-challenges
#12
REVIEW
Sriram Padmanaban, Peng Zhang, Ray A Hare, Mark W Sutherland, Anke Martin
Interspecific hybridisation between hexaploid and tetraploid wheat species leads to the development of F1 pentaploid hybrids with unique chromosomal constitutions. Pentaploid hybrids derived from bread wheat (Triticum aestivum L.) and durum wheat (Triticum turgidum spp. durum Desf.) crosses can improve the genetic background of either parent by transferring traits of interest. The genetic variability derived from bread and durum wheat and transferred into pentaploid hybrids has the potential to improve disease resistance, abiotic tolerance, and grain quality, and to enhance agronomic characters...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28353039/a-feasibility-and-efficacy-trial-of-a-hand-held-humidification-device-in-patients-undergoing-radiotherapy-for-head-and-neck-cancer
#13
Priyanka Ghosh, Ann A Lazar, William R Ryan, Sue S Yom
PURPOSE: This study aimed to evaluate the effects of warm-mist humidification during and after head and neck radiation therapy (HN RT) on quality of life (QOL), as measured by the M. D. Anderson Symptom Inventory-Head and Neck (MDASI-HN) HN score. A secondary aim was to compare QOL among compliers (≥60% of protocol-recommended usage) versus non-compliers. METHODS: Twenty patients self-administered a hand-held, self-sterilizing humidification device for a recommended time of at least 15 min twice daily for 12 weeks...
March 28, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28351879/a-non-gas-based-cryotherapy-system-for-the-treatment-of-cervical-intraepithelial-neoplasia-a-mixed-methods-approach-for-initial-development-and-testing
#14
Miriam Cremer, Proma Paul, Katie Bergman, Michael Haas, Mauricio Maza, Albert Zevallos, Miguel Ossandon, Jillian D Garai, Jennifer L Winkler
BACKGROUND: Gas-based cryotherapy is the most widely used treatment strategy for cervical intraepithelial neoplasia (CIN) in low-resource settings, but reliance on gas presents challenges in low- and middle-income countries (LMICs). Our team adapted the original CryoPen Cryosurgical System, a cryotherapy device that does not require compressed gas and is powered by electricity, for use in LMICs. METHODS: A mixed-methods approach was used involving both qualitative and quantitative methods...
March 24, 2017: Global Health, Science and Practice
https://www.readbyqxmd.com/read/28342610/intentionally-induced-intestinal-barrier-dysfunction-causes-inflammation-affects-metabolism-and-reduces-productivity-in-lactating-holstein-cows
#15
S K Kvidera, M J Dickson, M Abuajamieh, D B Snider, M V Sanz Fernandez, J S Johnson, A F Keating, P J Gorden, H B Green, K M Schoenberg, L H Baumgard
Study objectives were to evaluate the effects of intentionally reduced intestinal barrier function on productivity, metabolism, and inflammatory indices in otherwise healthy dairy cows. Fourteen lactating Holstein cows (parity 2.6 ± 0.3; 117 ± 18 d in milk) were enrolled in 2 experimental periods. Period 1 (5 d) served as the baseline for period 2 (7 d), during which cows received 1 of 2 i.v. treatments twice per day: sterile saline or a gamma-secretase inhibitor (GSI; 1.5 mg/kg of body weight). Gamma-secretase inhibitors reduce intestinal barrier function by inhibiting crypt cell differentiation into absorptive enterocytes...
May 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28334298/distribution-and-persistence-of-sterile-screwworms-diptera-calliphoridae-released-at-the-panama-colombia-border
#16
Steven R Skoda, Pamela L Phillips, Agustin Sagel, Muhammad F Chaudhury
The sterile insect technique is used by the Comisión Panamá - Estados Unidos para la Erradicación y Prevención del Gusano Barrenador del Ganado (COPEG) to maintain a barrier at the border of Panama and Colombia to prevent screwworms, Cochliomyia hominivorax (Coquerel), from South America reinfesting North America. Before studying the distribution and persistence of sterilized, mass-produced screwworms released in the barrier zone, the utility of applying fluorescent dust (∼1.0 mg/fly) to pupae and to newly emerged adults was evaluated to determine the potential effect on fly survival...
April 1, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/28333156/an-in-vitro-bacterial-surface-migration-assay-underneath-sterile-barrier-material-commonly-found-in-a-hospital-setting
#17
J D Shih, L S Y Wood, C L Dambkowski, S Torres, E F Chehab, R Venook, J K Wall
OBJECTIVE: To determine what barrier material used in hospital neonatal intensive care units most effectively blocks bacterial migration. STUDY DESIGN: Bacterial migration distance was compared across simple and complex solid media using Escherichia coli, an early and common neonatal gut colonizer, and Staphylococcus aureus, a common skin bacterium, across polystyrene, medical-grade silicone, hydrocolloid dressing and transparent film dressing as barrier materials on complex solid media...
March 23, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/28320592/facilitators-and-barriers-of-parental-attitudes-and-beliefs-toward-school-located-influenza-vaccination-in-the-united-states-systematic-review
#18
REVIEW
Gloria J Kang, Rachel K Culp, Kaja M Abbas
The study objective was to identify facilitators and barriers of parental attitudes and beliefs toward school-located influenza vaccination in the United States. In 2009, the Advisory Committee on Immunization Practices of the Centers for Disease Control and Prevention expanded their recommendations for influenza vaccination to include school-aged children. We conducted a systematic review of studies focused on facilitators and barriers of parental attitudes toward school-located influenza vaccination in the United States from 1990 to 2016...
April 11, 2017: Vaccine
https://www.readbyqxmd.com/read/28303904/microbiota-a-key-orchestrator-of-cancer-therapy
#19
REVIEW
Soumen Roy, Giorgio Trinchieri
The microbiota is composed of commensal bacteria and other microorganisms that live on the epithelial barriers of the host. The commensal microbiota is important for the health and survival of the organism. Microbiota influences physiological functions from the maintenance of barrier homeostasis locally to the regulation of metabolism, haematopoiesis, inflammation, immunity and other functions systemically. The microbiota is also involved in the initiation, progression and dissemination of cancer both at epithelial barriers and in sterile tissues...
May 2017: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/28292894/receptor-mincle-promotes-skin-allergies-and-is-capable-of-recognizing-cholesterol-sulfate
#20
Alexey V Kostarnoy, Petya G Gancheva, Bernd Lepenies, Amir I Tukhvatulin, Alina S Dzharullaeva, Nikita B Polyakov, Daniil A Grumov, Daria A Egorova, Andrey Y Kulibin, Maxim A Bobrov, Ekaterina A Malolina, Pavel A Zykin, Andrey I Soloviev, Evgeniy Riabenko, Diana V Maltseva, Dmitry A Sakharov, Alexander G Tonevitsky, Lyudmila V Verkhovskaya, Denis Y Logunov, Boris S Naroditsky, Alexander L Gintsburg
Sterile (noninfected) inflammation underlies the pathogenesis of many widespread diseases, such as allergies and autoimmune diseases. The evolutionarily conserved innate immune system is considered to play a key role in tissue injury recognition and the subsequent development of sterile inflammation; however, the underlying molecular mechanisms are not yet completely understood. Here, we show that cholesterol sulfate, a molecule present in relatively high concentrations in the epithelial layer of barrier tissues, is selectively recognized by Mincle (Clec4e), a C-type lectin receptor of the innate immune system that is strongly up-regulated in response to skin damage...
March 28, 2017: Proceedings of the National Academy of Sciences of the United States of America
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