keyword
MENU ▼
Read by QxMD icon Read
search

The New England Journal of Medicine

keyword
https://www.readbyqxmd.com/read/29149153/analysis-of-reporting-bias-in-vertebral-augmentation
#1
Douglas P Beall, Sean M Tutton, Kieran Murphy, Wayne Olan, Christopher Warner, Jack B Test
Osteoporotic vertebral compression fractures (OVCFs) are a significant cause of morbidity and mortality in the United States and worldwide, with estimates of 750,000 to 1.5 million occurring annually. As the elderly population continues to increase, the incidence of OVCFs will continue to rise, as will the morbidity and mortality associated with this condition. Vertebral augmentation (VA) was almost universally accepted as the appropriate treatment modality prior to 2 sham trials published in 2009 by the New England Journal of Medicine (NEJM)...
November 2017: Pain Physician
https://www.readbyqxmd.com/read/29101129/dissemination-of-2014-dual-antiplatelet-therapy-dapt-trial-results-a-systematic-review-of-scholarly-and-media-attention-over-7-months
#2
Melissa K Sharp, Romana Haneef, Philippe Ravaud, Isabelle Boutron
OBJECTIVE: To explore how the results from the 2014 dual antiplatelet therapy (DAPT) trial were disseminated to the scientific community and online media. DESIGN: A a systematic review of scholarly and public attention surrounding the DAPT study. SETTINGS: Data were collected from the ISI Web of Knowledge, Google Scholar, PubMed Commons, EurekAlert, the DAPT study website (www.daptstudy.org) and the New England Journal of Medicine website (for scholarly attention) and Altmetric Explorer, Snap Bird, YouTube (for public attention) citing DAPT study results appearing from 16 November 2014 to 10 June 2015...
November 3, 2017: BMJ Open
https://www.readbyqxmd.com/read/29058806/an-epidemic-of-multiple-sclerosis-and-falling-infection-rates-reflecting-on-comparisons-made-and-the-rising-ms-incidence-in-bach-s-nejm-2002-figure
#3
Helen Tremlett, Robyn Lucas
Myths are common in science and research. Findings from a publication in a high impact, influential journal, can be accepted as fact, with an assumption that the peer review process ensures study validity. Repeated presentation of graphical representations or summary statements at scientific meetings and through citation in publications can cement the findings such that they guide 'understanding' of science and future research directions. Such may be the case with the multiple sclerosis (MS) related epidemiology presented within a wider review article published in 2002 in the New England Journal of Medicine (NEJM)...
October 23, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28993088/hip-and-knee-arthroplasty-orthopedic-literature-in-medical-journals-is-it-negatively-biased
#4
Ronald E Delanois, Chukwuweike U Gwam, Nicolas S Piuzzi, Morad Chughtai, Arthur L Malkani, Peter M Bonutti, Michael A Mont
BACKGROUND: Healthcare policy is often determined by well-designed studies most often published in high-impact medical journals. However, concern about the presence of publication bias against lower-extremity arthroplasty-related studies has called into question some of the validity of certain reports. There are only a few studies investigating the presence of the bias in high-impact medical journals against lower-extremity arthroplasty intervention, particularly in the Journal of American Medical Association (JAMA), New England Journal of Medicine (NEJM), and the Lancet...
September 19, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28954803/temporal-trends-in-use-of-composite-end-points-in-major-cardiovascular-randomized-clinical-trials-in-prominent-medical-journals
#5
Nigel S Tan, Sammy H Ali, Gerald Lebovic, Muhammad Mamdani, Andreas Laupacis, Andrew T Yan
BACKGROUND: Cardiovascular mortality has decreased over the past 5 decades, making it increasingly difficult to demonstrate significant benefits of new therapies in randomized clinical trials. We sought to determine whether the use of composite end points in major cardiovascular trials has changed over time and examine temporal trends in the clinical importance of individual components of these composite end points. METHODS AND RESULTS: Using a validated search strategy, we searched MEDLINE for randomized trials of therapies for primary or secondary cardiovascular prevention published in New England Journal of Medicine, The Lancet, and the Journal of the American Medical Association between 1986 and 2015...
October 2017: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/28954288/two-by-two-factorial-cancer-treatment-trials-is-sufficient-attention-being-paid-to-possible-interactions
#6
REVIEW
Boris Freidlin, Edward L Korn
Factorial 2 × 2 designs can be used to combine evaluation of two treatments in a single study. The standard analysis approach is based on a factorial analysis that evaluates each treatment by pooling data over the other treatment. This approach relies on the assumption that the effect of each treatment is not substantially affected by the other treatment. In many oncology settings, this no-interaction assumption cannot be adequately supported at the time the trial is designed. In this Commentary, we consider current practices for the design and analysis of factorial trials by performing a survey of factorial treatment trials published in the Journal of the National Cancer Institute, Journal of Clinical Oncology, and the New England Journal of Medicine (2007-2016)...
September 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28894852/top-100-cited-classic-articles-in-breast-cancer-research
#7
Erdal Uysal
OBJECTIVE: This study aimed to analyze 100 most cited articles in breast cancer research. MATERIALS AND METHODS: The data in this study were obtained by a search conducted on the Web of Science (WOS). In brief, the term "breast cancer" was typed in the search box of WOS basic research including all the years and the data. The analysis was carried out by compiling the top 100 cited articles in the shortlist as sorted by the journals, categories of the studies, the countries, the centers, the authors and the publication date...
July 2017: Eur J Breast Health
https://www.readbyqxmd.com/read/28757260/comparison-between-publicly-accessible-publications-registries-and%C3%A2-protocols-of-phase-iii-trials-indicated-persistence-of-selective-outcome%C3%A2-reporting
#8
Sheng Zhang, Fei Liang, Wenfeng Li
OBJECTIVES: The decision to make protocols of phase III randomized controlled trials (RCTs) publicly accessible by leading journals was a landmark event in clinical trial reporting. Here, we compared primary outcomes defined in protocols with those in publications describing the trials and in trial registration. STUDY DESIGN AND SETTING: We identified phase III RCTs published between January 1, 2012, and June 30, 2015, in The New England Journal of Medicine, The Lancet, The Journal of the American Medical Association, and The BMJ with available protocols...
July 27, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28749016/trends-in-study-design-and-the-statistical-methods-employed-in-a-leading-general-medicine-journal
#9
M Gosho, Y Sato, K Nagashima, S Takahashi
WHAT IS KNOWN AND OBJECTIVE: Study design and statistical methods have become core components of medical research, and the methodology has become more multifaceted and complicated over time. The study of the comprehensive details and current trends of study design and statistical methods is required to support the future implementation of well-planned clinical studies providing information about evidence-based medicine. Our purpose was to illustrate study design and statistical methods employed in recent medical literature...
July 27, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/28744998/science-or-popular-media-what-drives-breast-cancer-online-activity
#10
Ryan Sugrue, Erica Carthy, M E Kelly, Karl J Sweeney
Google Trends is reflective of international awareness. Since its launch in 2004, there have been several landmark publications, international awareness campaigns, and mainstream-media events that involve breast cancer. The aim of this study was to assess the impact of landmark academic publications vs mainstream-media announcements in driving online breast cancer activity via Google Trends. Ten breast cancer-related themes or landmark publications (five academic publications and five media-related events) were used to compare the impact of online search activity...
July 26, 2017: Breast Journal
https://www.readbyqxmd.com/read/28720618/interpretation-of-cis-in-clinical-trials-with-non-significant-results-systematic-review-and-recommendations
#11
Jennifer S Gewandter, Michael P McDermott, Rachel A Kitt, Jenna Chaudari, James G Koch, Scott R Evans, Robert A Gross, John D Markman, Dennis C Turk, Robert H Dworkin
OBJECTIVES: Interpretation of CIs in randomised clinical trials (RCTs) with treatment effects that are not statistically significant can distinguish between results that are 'negative' (the data are not consistent with a clinically meaningful treatment effect) or 'inconclusive' (the data remain consistent with the possibility of a clinically meaningful treatment effect). This interpretation is important to ensure that potentially beneficial treatments are not prematurely abandoned in future research or clinical practice based on invalid conclusions...
July 18, 2017: BMJ Open
https://www.readbyqxmd.com/read/28718304/the-role-of-surgery-in-low-grade-gliomas-do-timing-and-extent-of-resection-matter
#12
Hugues Duffau
Hugues Duffau is a Professor and Chairman of the Neurosurgery Department in the Montpellier University Medical Center and Head of the INSERM 1051 Team "plasticity of the central nervous system, human stem cells and glial tumors" at the Institute for Neurosciences of Montpellier (France). He is an expert in the awake cognitive neurosurgery of slow-growing brain tumors, such as low-grade gliomas, a routine which he has developed since 20 years. His fundamental approach is centered on the concepts of the brain connectomics and neuroplasticity, breaking with the traditional localizationist view of cerebral processing...
July 18, 2017: CNS Oncology
https://www.readbyqxmd.com/read/28698337/protocol-for-a-multicentre-randomised-feasibility-study-evaluating-the-impact-of-a-prognostic-model-for-management-of-blunt-chest-wall-trauma-patients-stumbl-trial
#13
Ceri Battle, Zoe Abbott, Hayley A Hutchings, Claire O'Neill, Sam Groves, Alan Watkins, Fiona E Lecky, Sally Jones, James Gagg, Richard Body, Philip A Evans
INTRODUCTION: A new prognostic model has been developed and externally validated, the aim of which is to assist in the management of the blunt chest wall trauma patient in the emergency department (ED). A definitive randomised controlled trial (impact trial) is required to assess the clinical and cost effectiveness of the new model before it can be accepted in clinical practice. The purpose of this trial is to assess the feasibility and acceptability of such a definitive trial and inform its design...
July 10, 2017: BMJ Open
https://www.readbyqxmd.com/read/28697343/redefining-hormonal-therapy-for-advanced-prostate-cancer-results-from-the-latitude-and-chaarted-studies
#14
Eric J Small
Two papers published recently in the New England Journal of Medicine describe the utility of abiraterone acetate, an androgen biosynthesis inhibitor, in the early treatment of metastatic prostate cancer. In addition to establishing a new standard of care, these two articles pose a number of important questions for future investigation.
July 10, 2017: Cancer Cell
https://www.readbyqxmd.com/read/28678600/discussing-the-predictive-prognostic-and-therapeutic-value-of-germline-dna-repair-gene-mutations-in-metastatic-prostate-cancer-patients
#15
Ralph J Hauke, Tristan M Sissung, William D Figg
Recent trends in cancer therapy have begun emphasizing the use of precision medicine, especially genetic tools, in the evaluation of malignancies and decision-making. Prostate cancer is a malignancy where the benefits and utility of screening and early treatment are still heavily controversial. A recent paper in the New England Journal of Medicine found that patients with metastatic prostate cancer presented germline mutations in DNA-repair genes at a significantly higher incidence than those with localized prostate cancer...
August 3, 2017: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/28675916/-termination-of-reimbursement-of-arthroscopy-in-osteoarthritis-of-the-knee-is-this-decision-based-on-scientific-grounds
#16
Thoralf Randolph Liebs, Steffen Berger
Background In Germany, arthroscopy of the knee used to be an accepted procedure in the treatment of osteoarthritis of the knee. However, as of April 1, 2016 reimbursement for this procedure has been discontinued. This was a decision of the Joint Federal Committee (Gemeinsamer Bundesausschuss, G-BA). That decision was based on a report of the German Institute for Quality and Efficiency in Health Care (IQWiG). This report is essentially based on a few studies, three of which have been published in the renowned New England Journal of Medicine...
August 2017: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/28659198/-henry-beecher-and-medical-science-the-50th-anniversary-of-a-famous-article
#17
N Jacobs, F G Huisman
In 2016, it had been exactly half a century ago that Henry Beecher published his article 'Ethics and clinical research' in The New England Journal of Medicine. Today, this article is considered a turning point in the history of medical research ethics. On the occasion of the fiftieth anniversary of this famous article, we are looking back on this turbulent period in the history of medicine.
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28638708/citation-classics-in-central-nervous-system-inflammatory-demyelinating-disease
#18
Jee-Eun Kim, Kang M Park, Yerim Kim, Dae Y Yoon, Jong S Bae
OBJECTIVES: To identify and analyze the characteristics of the most influential articles about central nervous system (CNS) inflammatory demyelinating disease. MATERIALS AND METHODS: The Institute for Scientific Information (ISI) Web of Science database and the 2014 Journal Citation Reports Science Edition were used to retrieve the top 100 cited articles on CNS inflammatory demyelinating disease. The citation numbers, journals, years of publication, authorships, article types, subjects and main issues were analyzed...
June 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28580651/data-fabrication-and-other-reasons-for-non-random-sampling-in-5087-randomised-controlled-trials-in-anaesthetic-and-general-medical-journals
#19
J B Carlisle
Randomised, controlled trials have been retracted after publication because of data fabrication and inadequate ethical approval. Fabricated data have included baseline variables, for instance, age, height or weight. Statistical tests can determine the probability of the distribution of means, given their standard deviation and the number of participants in each group. Randomised, controlled trials have been retracted after the data distributions have been calculated as improbable. Most retracted trials have been written by anaesthetists and published by specialist anaesthetic journals...
June 4, 2017: Anaesthesia
https://www.readbyqxmd.com/read/28515198/post-authorisation-passive-enhanced-safety-surveillance-of-seasonal-influenza-vaccines-protocol-of-a-pilot-study-in-england
#20
Simon de Lusignan, Gaël Dos Santos, Ana Correa, François Haguinet, Ivelina Yonova, Florence Lair, Rachel Byford, Filipa Ferreira, Karen Stuttard, Tom Chan
AIM: To pilot enhanced safety surveillance of seasonal influenza vaccine meeting the European Medicines Agency (EMA) requirement to rapidly detect a significant increase in the frequency or severity of adverse events of interest (AEIs), which may indicate risk from the new season's vaccine. STUDY DESIGN: A prospective passive enhanced safety surveillance combining data collection from adverse drug reaction (ADR) cards with automated collection of pseudonymised routinely collected electronic health record (EHR) data...
May 17, 2017: BMJ Open
keyword
keyword
85026
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"