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https://www.readbyqxmd.com/read/28210564/more-misinformation-on-breast-cancer-screening
#1
COMMENT
Daniel B Kopans
Unfortunately, a great deal of misinformation has accumulated in the breast cancer screening literature that is based on flawed analyses in an effort to reduce access to screening. Quite remarkably, much of this has come from publications in previously highly respected medical journals. In several papers the intervention (mammography screening) is faulted yet the analyses provided no data on who participated in mammography screening, and which cancers were detected by mammography screening. It is remarkable that a highly respected journal can fault an intervention with no data on the intervention...
February 2017: Gland Surgery
https://www.readbyqxmd.com/read/28107475/review-and-analysis-of-publication-trends-over-three-decades-in-three-high-impact-medicine-journals
#2
Alexander Ivanov, Beata A Kaczkowska, Saadat A Khan, Jean Ho, Morteza Tavakol, Ashok Prasad, Geetha Bhumireddy, Allan F Beall, Igor Klem, Parag Mehta, William M Briggs, Terrence J Sacchi, John F Heitner
CONTEXT: Over the past three decades, industry sponsored research expanded in the United States. Financial incentives can lead to potential conflicts of interest (COI) resulting in underreporting of negative study results. OBJECTIVE: We hypothesized that over the three decades, there would be an increase in: a) reporting of conflict of interest and source of funding; b) percentage of randomized control trials c) number of patients per study and d) industry funding...
2017: PloS One
https://www.readbyqxmd.com/read/28103591/searching-the-footprints-of-pioneers-on-neurology-a-bibliometric-analysis
#3
Kang Min Park, Jee-Eun Kim, Yerim Kim, Si Eun Kim, Dae Young Yoon, Jong Seok Bae
BACKGROUND: We identify the most cited articles that have influenced the clinical practices of neurologists. METHODS: We first analyzed the top 100 cited articles published in 50 neurology journals with high impact factors. We collected all of the original articles on clinical neurology published in all 554 medical journals. The Institute for Scientific Information Web of Science search tools were used to identify the top 100 cited articles in the database of Journal Citation Reports since 1950, which were then manually reviewed to discover their contents...
January 20, 2017: European Neurology
https://www.readbyqxmd.com/read/28093443/impact-of-advanced-autonomous-non-medical-practitioners-in-emergency-care-protocol-for-a-scoping-study
#4
Mark Sujan, Hannah Howard-Franks, Garry Swann, Kirsti Soanes, Catherine Pope, Robert Crouch, Sophie Staniszewska, Elaine Maxwell, Huayi Huang, Matthew Cooke
INTRODUCTION: Emergency care services are looking for new models of care delivery to deal with changing patient demographics and increased pressures. It has been suggested that advanced non-medical practitioners might be valuable for delivering such new models of care. However, it is not clear what the impact of the deployment of advanced non-medical practitioners in emergency care is. This scoping study addresses the following research question: What is known from the literature about the different types of impact of the deployment of advanced (autonomous) non-medical practitioners in emergency care? METHODS AND ANALYSIS: A scoping study will be undertaken to examine and map the impact of the deployment of advanced non-medical practitioners in emergency care...
January 16, 2017: BMJ Open
https://www.readbyqxmd.com/read/28050393/metronomic-chemotherapy-seems-prowess-to-battle-against-cancer-in-current-scenario
#5
Prema Muthusamy, Krishnan Vengadaragava Chary, G K Nalini
INTRODUCTION: Metronomic chemotherapy is an emerging method of chemotherapy. Metronomic 'lowdose' chemotherapy regimen induces tumour dormancy and reduces cancer resistance against anticancer drugs. It tends to improve overall success rate of cancer chemotherapy than conventional cyclical regimen. AIM: The aim of this systemic review was to provide comprehensive data of metronomic chemotherapy trials, regimens used and it's outcome in cancer therapeutics. MATERIALS AND METHODS: Fifty chemotherapy trial data were searched sequentially from web...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28011448/comparison-of-primary-outcomes-in-protocols-public-clinical-trial-registries-and-publications-the-example-of-oncology-trials
#6
A Perlmutter, V-T Tran, A Dechartres, P Ravaud
BACKGROUND: Protocols are often unavailable to peer-reviewers and readers. To detect outcome reporting bias (ORB), readers usually have to resort to publicly available descriptions of study design such as clinical-trial registries. We compared primary outcomes in protocols, ClinicalTrials.gov and publications of oncology trials and evaluated the use of ClinicalTrials.gov as compared with protocols in detecting discrepancies between planned and published outcomes. METHOD: We searched for phase III oncology trials registered in ClinicalTrials...
December 22, 2016: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/27979724/a-peer-reviewed-instructional-video-is-as-effective-as-a-standard-recorded-didactic-lecture-in-medical-trainees-performing-chest-tube-insertion-a-randomized-control-trial
#7
Tomas J Saun, Scott Odorizzi, Celine Yeung, Marjorie Johnson, Glen Bandiera, Shelly P Dev
OBJECTIVE: Online medical education resources are becoming an increasingly used modality and many studies have demonstrated their efficacy in procedural instruction. This study sought to determine whether a standardized online procedural video is as effective as a standard recorded didactic teaching session for chest tube insertion. DESIGN: A randomized control trial was conducted. Participants were taught how to insert a chest tube with either a recorded didactic teaching session, or a New England Journal of Medicine (NEJM) video...
December 12, 2016: Journal of Surgical Education
https://www.readbyqxmd.com/read/27965044/criteria-for-use-of-composite-end-points-for-competing-risks-a-systematic-survey-of-the-literature-with-recommendations
#8
REVIEW
Veena Manja, Siwar AlBashir, Gordon Guyatt
BACKGROUND: Composite end points are frequently used in reports of clinical trials. One rationale for the use of composite end points is to account for competing risks. In the presence of competing risks, the event rate of a specific event depends on the rates of other competing events. One proposed solution is to include all important competing events in one composite end point. Clinical trialists require guidance regarding when this approach is appropriate. OBJECTIVES: To identify publications describing criteria for use of composite end points for competing risk and to offer guidance regarding when a composite end point is appropriate on the basis of competing risks...
February 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/27923680/the-100-most-cited-manuscripts-in-emergency-abdominal-surgery-a-bibliometric-analysis
#9
Thomas Ellul, Nicholas Bullock, Tarig Abdelrahman, Arfon G M T Powell, Jolene Witherspoon, Wyn G Lewis
BACKGROUND: The number of citations a scientific article receives provides a good indication of its impact within any given field. This bibliometric analysis aimed to identify the 100 most cited articles in Emergency Abdominal Surgery (EAS), to highlight key areas of interest and identify those that have most significantly shaped contemporary clinical practice in this newly evolving surgical specialty. This is of increasing relevance as concerns grow regarding the variable and suboptimal outcomes in Emergency General Surgery...
January 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/27898350/cronkhite-canada-syndrome-complicated-by-pulmonary-embolism-a-case-report
#10
Neha L Nemade, Urvi B Shukla, Gajanan D Wagholikar
INTRODUCTION: Cronkhite Canada Syndrome (CCS) is a rare syndrome, described in 1955 by Americans, Leonard Wolsey Cronkhite and Wilma Jeanne Canada in the New England Journal of Medicine [1]. About 450 cases have been reported. Complications, like malignant transformation, unprovoked thromboembolism is known. Since there is wide variability in medical presentation, no definitive diagnostic and treatment protocol s have been set. The mortality remains at 55%. CASE PRESENTATION: We report a case of a 50 year old male patient presenting with diarrhea, weight loss, abdominal pain, ectodermal features...
November 17, 2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27896967/methods-to-ensure-the-reproducibility-of-biomedical-research
#11
Konrad J Karczewski, Nicholas P Tatonetti, Arjun K Manrai, Chirag J Patel, C Titus Brown, John P A Ioannidis
Science is not done in a vacuum - across fields of biomedicine, scientists have built on previous research and used data published in previous papers. A mainstay of scientific inquiry is the publication of one's research and recognition for this work is given in the form of citations and notoriety - ideally given in proportion to the quality of the work. Academic incentives, however, may encourage individual researchers to prioritize career ambitions over scientific truth. Recently, the New England Journal of Medicine published a commentary calling scientists who repurpose data "research parasites" who misuse data generated by others to demonstrate alternative hypotheses...
2016: Pacific Symposium on Biocomputing
https://www.readbyqxmd.com/read/27858205/statistical-inference-in-abstracts-of-major-medical-and-epidemiology-journals-1975-2014-a-systematic-review
#12
REVIEW
Andreas Stang, Markus Deckert, Charles Poole, Kenneth J Rothman
Since its introduction in the twentieth century, null hypothesis significance testing (NHST), a hybrid of significance testing (ST) advocated by Fisher and null hypothesis testing (NHT) developed by Neyman and Pearson, has become widely adopted but has also been a source of debate. The principal alternative to such testing is estimation with point estimates and confidence intervals (CI). Our aim was to estimate time trends in NHST, ST, NHT and CI reporting in abstracts of major medical and epidemiological journals...
November 17, 2016: European Journal of Epidemiology
https://www.readbyqxmd.com/read/27855102/non-inferiority-trials-are-they-inferior-a-systematic-review-of-reporting-in-major-medical-journals
#13
Sunita Rehal, Tim P Morris, Katherine Fielding, James R Carpenter, Patrick P J Phillips
OBJECTIVE: To assess the adequacy of reporting of non-inferiority trials alongside the consistency and utility of current recommended analyses and guidelines. DESIGN: Review of randomised clinical trials that used a non-inferiority design published between January 2010 and May 2015 in medical journals that had an impact factor >10 (JAMA Internal Medicine, Archives Internal Medicine, PLOS Medicine, Annals of Internal Medicine, BMJ, JAMA, Lancet and New England Journal of Medicine)...
October 7, 2016: BMJ Open
https://www.readbyqxmd.com/read/27852915/levels-of-influence-habituation-and-the-prevalence-of-declared-conflicts-of-interest
#14
REVIEW
Jillian R H Bernstein, George Maliha, Jaimo Ahn, Joseph Bernstein
BACKGROUND: The International Committee of Medical Journal Editors has devised a system of mandatory disclosure, under which authors are required to disclose all conflicts of interest and the sources of support for the submitted research. Because payments from industry to physicians generally are common, it is likely that many authors of medical manuscripts will have information to disclose. As a result, the signal-to-noise ratio of such declarations may be low, thereby undermining the effectiveness of disclosure...
November 16, 2016: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/27843677/commentary-on-laminectomy-plus-fusion-versus-laminectomy-alone-for-lumbar-spondylolisthesis-by-ghogawala-z-dziura-j-butler-we-dai-f-terrin-n-magge-sn-et-al-nejm-2016-374-15-1424-34
#15
Nancy E Epstein
BACKGROUND: How does an article involving only 66 patients randomized into two spinal surgical groups get into the New England Journal of Medicine? Nevertheless, this one did. The article by Ghogawala et al. entitled Laminectomy plus fusion versus laminectomy alone for lumbar spondylolisthesis, compared the efficacy/outcomes of pedicle/screw/rod instrumented posterolateral lumbar fusions vs. decompressions alone for treating lumbar stenosis with grade I degenerative spondylolisthesis (DS)...
2016: Surgical Neurology International
https://www.readbyqxmd.com/read/27843676/commentary-on-a-randomized-controlled-trial-of-fusion-surgery-for-lumbar-spinal-stenosis-forsth-p-%C3%A3-lafsson-g-carlsson-t-frost-a-borgstr%C3%A3-m-f-fritzell-p-et-al-n-eng-j-med-2016-374-1414-23
#16
Nancy E Epstein
BACKGROUND: This article by Forsth et al. published in the New England Journal of Medicine entitled A randomized controlled trial of fusion surgery for lumbar spinal stenosis determined that decompressions alone vs. decompressions/fusions were equally effective in treating 1-2 level spinal stensois with/without degenerative spondylolisthesis (DS). Additionally, decompression alone reduced the perioperative morbidity, while reducuing the length of hospital stay (LOS), operative time, and surgical costs...
2016: Surgical Neurology International
https://www.readbyqxmd.com/read/27814814/point-the-new-england-journal-of-medicine-article-suggesting-overdiagnosis-from-mammography-screening-is-scientifically-incorrect-and-should-be-withdrawn
#17
Daniel B Kopans
No abstract text is available yet for this article.
November 2016: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/27757242/no-difference-found-in-time-to-publication-by-statistical-significance-of-trial-results-a-methodological-review
#18
L Jefferson, C Fairhurst, E Cooper, C Hewitt, T Torgerson, L Cook, P Tharmanathan, S Cockayne, D Torgerson
OBJECTIVE: Time-lag from study completion to publication is a potential source of publication bias in randomised controlled trials. This study sought to update the evidence base by identifying the effect of the statistical significance of research findings on time to publication of trial results. DESIGN: Literature searches were carried out in four general medical journals from June 2013 to June 2014 inclusive (BMJ, JAMA, the Lancet and the New England Journal of Medicine)...
October 2016: JRSM Open
https://www.readbyqxmd.com/read/27651214/commercial-conflict-of-interest-and-medical-publication-what-should-the-practising-physician-do-about-it
#19
Prem Pais
I read with interest the comment by Mark Wilson, which deals with possible conflict of interest (CoI) affecting publications in academic medical journals. This comment has specifically targeted the New England Journal of Medicine (NEJM) and its editor-in-chief Jeffrey Drazen on the "Vioxx scandal" which broke 15 years ago. Wilson's comment seems to be in response to a blog by Natarajan on CoI in medical publications. In the blog Natarajan writes of commercial CoI biasing publication of clinical trials and cites, among other examples, a publication in the NEJM on trials of voriconazole...
October 2016: Indian Journal of Medical Ethics
https://www.readbyqxmd.com/read/27637413/reporting-on-data-monitoring-committees-in-neonatal-randomised-controlled-trials-is-inconsistent
#20
L M Perrem, S Gosling, I Ravikumar, A S Khashan, J Miletin, C A Ryan, E Dempsey
AIM: To evaluate the reported use of data monitoring committees (DMCs), the frequency of interim analysis, prespecified stopping rules and early trial termination in neonatal randomised controlled trials (RCTs). METHODS: We reviewed neonatal RCTs published in four high-impact general medical journals, specifically looking at safety issues including documented involvement of a DMC, stated interim analysis, stopping rules and early trial termination. We searched all journal issues over an 11-year period (2003-2013) and recorded predefined parameters on each item for RCTs meeting inclusion criteria...
January 2017: Acta Paediatrica
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