Karen Blackmon, Randall Waechter, Barbara Landon, Trevor Noël, Calum Macpherson, Tyhiesia Donald, Nikita Cudjoe, Roberta Evans, Kemi S Burgen, Piumi Jayatilake, Vivian Oyegunle, Otto Pedraza, Samah Abdel Baki, Thomas Thesen, Dennis Dlugos, Geetha Chari, Archana A Patel, Elysse N Grossi-Soyster, Amy R Krystosik, A Desiree LaBeaud
Children with Congenital Zika Syndrome and microcephaly are at high risk for epilepsy; however, the risk is unclear in normocephalic children with prenatal Zika virus (ZIKV) exposure [Exposed Children (EC)]. In this prospective cohort study, we performed epilepsy screening in normocephalic EC alongside a parallel group of normocephalic unexposed children [Unexposed Children (UC)]. We compared the incidence rate of epilepsy among EC and UC at one year of life to global incidence rates. Pregnant women were recruited from public health centers during the ZIKV outbreak in Grenada, West Indies and assessed for prior ZIKV infection using a plasmonic-gold platform that measures IgG antibodies in serum...
November 30, 2020: PLoS Neglected Tropical Diseases