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https://www.readbyqxmd.com/read/28433087/paternal-age-alters-social-development-in-offspring
#1
Magdalena Janecka, Claire M A Haworth, Angelica Ronald, Eva Krapohl, Francesca Happé, Jonathan Mill, Leonard C Schalkwyk, Cathy Fernandes, Abraham Reichenberg, Frühling Rijsdijk
OBJECTIVE: Advanced paternal age (APA) at conception has been linked with autism and schizophrenia in offspring, neurodevelopmental disorders that affect social functioning. The current study explored the effects of paternal age on social development in the general population. METHOD: We used multilevel growth modeling to investigate APA effects on socioemotional development from early childhood until adolescence, as measured by the Strengths and Difficulties Questionnaire (SDQ) in the Twins Early Development Study (TEDS) sample...
May 2017: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/28424947/neurodevelopmental-effects-of-antiepileptic-drugs
#2
Marissa Kellogg, Kimford J Meador
Increasing evidence suggests that exposure to certain antiepileptic drugs (AEDs) during critical periods of development may induce transient or long-lasting neurodevelopmental deficits across cognitive, motor and behavioral domains. The developing nervous system may endure prolonged chronic exposure to AEDs during pregnancy (in utero) or during childhood, which can lead to neurodevelopmental defects such as congenital neural tube defects, lower IQ, language deficits, autism and ADHD. To date, valproate is the most widely recognized AED to significantly negatively affect neurodevelopment, and demonstrates greater adverse effects than any other AEDs that have been assessed...
April 19, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28417257/additive-effect-of-congenital-heart-disease-and-early-developmental-disorders-on-attention-deficit-hyperactivity-disorder-and-autism-spectrum-disorder-a-nationwide-population-based-longitudinal-study
#3
Pei-Chen Tsao, Yu-Sheng Lee, Mei-Jy Jeng, Ju-Wei Hsu, Kai-Lin Huang, Shih-Jen Tsai, Mu-Hong Chen, Wen-Jue Soong, Yu Ru Kou
In this retrospective nationwide population-based case-control study, we investigated the impact of congenital heart disease (CHD) on the development of attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD), which remains unclear. Children aged <18 years that were diagnosed with CHD (n = 3552) between January 1, 1997 and December 31, 2009 were identified from the National Health Insurance Research Database in Taiwan. Non-CHD controls (n = 14,208) matched for age and sex (1:4) were selected from the same dataset...
April 17, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28415925/the-role-of-oxidative-stress-inflammation-and-acetaminophen-exposure-from-birth-to-early-childhood-in-the-induction-of-autism
#4
William Parker, Chi Dang Hornik, Staci Bilbo, Zoie E Holzknecht, Lauren Gentry, Rasika Rao, Shu S Lin, Martha R Herbert, Cynthia D Nevison
The wide range of factors associated with the induction of autism is invariably linked with either inflammation or oxidative stress, and sometimes both. The use of acetaminophen in babies and young children may be much more strongly associated with autism than its use during pregnancy, perhaps because of well-known deficiencies in the metabolic breakdown of pharmaceuticals during early development. Thus, one explanation for the increased prevalence of autism is that increased exposure to acetaminophen, exacerbated by inflammation and oxidative stress, is neurotoxic in babies and small children...
April 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28413424/environmental-factors-influencing-the-risk-of-autism
#5
REVIEW
Padideh Karimi, Elahe Kamali, Seyyed Mohammad Mousavi, Mojgan Karahmadi
Autism is a developmental disability with age of onset in childhood (under 3 years old), which is characterized by definite impairments in social interactions, abnormalities in speech, and stereotyped pattern of behaviors. Due to the progress of autism in recent decades, a wide range of studies have been done to identify the etiological factors of autism. It has been found that genetic and environmental factors are both involved in autism pathogenesis. Hence, in this review article, a set of environmental factors involved in the occurrence of autism has been collected, and finally, some practical recommendations for reduction of the risk of this devastating disease in children are represented...
2017: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/28406773/cluster-of-differentiation-5-cd5-levels-in-the-plasma-of-children-with-autism-spectrum-disorder-asd
#6
Dost Muhammad Halepoto, Abdulrahman Mohammed Alhowikan, Laila Al- Ayadhi
OBJECTIVE: To investigate the cluster of differentiation 5 (CD5) plasma levels and their association with childhood autism rating scale (CARS) in subjects with autism spectrum disorder (ASD) compared to age and gender matched healthy controls, and to explore the link between CD5, severity, and autoimmunity in autism. STUDY DESIGN: Case-control study. PLACE AND DURATION OF STUDY: Autism Research and Treatment Center, Al-Amodi Autism Research Chair, Department of Physiology, Faculty of Medicine, King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia, from October 2014 to May 2015...
March 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28406248/sensory-defects-and-developmental-delay-among-children-with-congenital-rubella-syndrome
#7
Michiko Toizumi, Giang Thi Huong Nguyen, Hideki Motomura, Thanh Huu Nguyen, Enga Pham, Ken-Ichi Kaneko, Masafumi Uematsu, Hien Anh Thi Nguyen, Duc Anh Dang, Masahiro Hashizume, Lay-Myint Yoshida, Hiroyuki Moriuchi
This study investigated the features of developmental difficulties combined with sensory defects in children with congenital rubella syndrome (CRS). Following a large rubella outbreak in Khanh Hoa Province, Vietnam, in 2011, we enrolled 41 children with CRS from September 2011 through May 2013. Fourteen participants died and six became untraceable by October 2013; the remaining 21 children were followed up from 2013 to 2015. Thirteen and seven participants had hearing and functional ophthalmological impairment, respectively...
April 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28405185/motor-stereotypies-a-pathophysiological-review
#8
REVIEW
Zsanett Péter, Melody E Oliphant, Thomas V Fernandez
Motor stereotypies are common, repetitive, rhythmic movements with typical onset in early childhood. While most often described in children with autism spectrum disorder (ASD) and intellectual disability (ID), stereotypies can also present without developmental delay and persist into adulthood. Stereotypies are often disruptive and harmful, both physically and socially, and effective evidence-based treatments are lacking. This can be attributed, in part, to our incomplete knowledge of the underlying biological and environmental risk...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28401440/coherence-and-content-of-relating-emotions-to-life-events-in-autism-spectrum-disorder-and-typical-development-a-cross-sectional-age-study
#9
Esther Ben-Itzchak, Michal Kirzon, Noa Peled, Ditza A Zachor
Understanding one's own emotions is an important part of social-emotional development in early childhood. Few studies have looked at the ability of children with autism spectrum disorder (ASD) to relate their own emotions to previous life events. Our previous study showed that the description of events that elicited specific emotions is qualitatively and quantitatively different in ASD in comparison to typically developing (TD) pre-adolescents. The current study evaluated differences in coherence and content of responses to questions on emotions in ASD and TD in two age groups...
April 12, 2017: Journal of Abnormal Child Psychology
https://www.readbyqxmd.com/read/28393290/maternal-exposure-to-childhood-abuse-is-associated-with-mate-selection-implications-for-autism-in-offspring
#10
Andrea L Roberts, Kristen Lyall, Marc G Weisskopf
Maternal experience of childhood abuse has been associated with offspring autism. To explore whether familial tendency towards autistic traits-presumably related to genetic predisposition-accounts for this association, we examined whether women who experienced childhood abuse were more likely to select mates with high levels of autistic traits, and whether parental autistic traits accounted for the association of maternal abuse and offspring autism in 209 autism cases and 833 controls. Maternal childhood abuse was strongly associated with high paternal autistic traits (severe abuse, OR = 3...
April 9, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28392909/neurogenetic-analysis-of-childhood-disintegrative-disorder
#11
Abha R Gupta, Alexander Westphal, Daniel Y J Yang, Catherine A W Sullivan, Jeffrey Eilbott, Samir Zaidi, Avery Voos, Brent C Vander Wyk, Pam Ventola, Zainulabedin Waqar, Thomas V Fernandez, A Gulhan Ercan-Sencicek, Michael F Walker, Murim Choi, Allison Schneider, Tammy Hedderly, Gillian Baird, Hannah Friedman, Cara Cordeaux, Alexandra Ristow, Frederick Shic, Fred R Volkmar, Kevin A Pelphrey
BACKGROUND: Childhood disintegrative disorder (CDD) is a rare form of autism spectrum disorder (ASD) of unknown etiology. It is characterized by late-onset regression leading to significant intellectual disability (ID) and severe autism. Although there are phenotypic differences between CDD and other forms of ASD, it is unclear if there are neurobiological differences. METHODS: We pursued a multidisciplinary study of CDD (n = 17) and three comparison groups: low-functioning ASD (n = 12), high-functioning ASD (n = 50), and typically developing (n = 26) individuals...
2017: Molecular Autism
https://www.readbyqxmd.com/read/28392908/shared-genetic-influences-between-dimensional-asd-and-adhd-symptoms-during-child-and-adolescent-development
#12
Evie Stergiakouli, George Davey Smith, Joanna Martin, David H Skuse, Wolfgang Viechtbauer, Susan M Ring, Angelica Ronald, David E Evans, Simon E Fisher, Anita Thapar, Beate St Pourcain
BACKGROUND: Shared genetic influences between attention-deficit/hyperactivity disorder (ADHD) symptoms and autism spectrum disorder (ASD) symptoms have been reported. Cross-trait genetic relationships are, however, subject to dynamic changes during development. We investigated the continuity of genetic overlap between ASD and ADHD symptoms in a general population sample during childhood and adolescence. We also studied uni- and cross-dimensional trait-disorder links with respect to genetic ADHD and ASD risk...
2017: Molecular Autism
https://www.readbyqxmd.com/read/28387533/the-impact-of-childhood-autism-spectrum-disorder-on-parent-s-labour-force-participation-can-parents-be-expected-to-be-able-to-re-join-the-labour-force
#13
Emily J Callander, Daniel B Lindsay
Parental employment is a significant factor in ensuring financial ability to access care for children with autism spectrum disorder. This article aimed to identify the influence of autism spectrum disorder on parental employment and whether childcare access may effect labour force participation using the Longitudinal Survey of Australian Children, with 12 years of follow-up data (2004-2015). Parental employment when the child was aged between 0 and 11 years was assessed. A significantly larger percentage of parents whose children had autism spectrum disorder were not in the labour force when their child was aged between 2-3 and 10-11 years...
March 1, 2017: Autism: the International Journal of Research and Practice
https://www.readbyqxmd.com/read/28383173/the-childhood-autism-spectrum-test-cast-spanish-adaptation-and-validation
#14
Paula Morales-Hidalgo, Joana Roigé-Castellví, Andreu Vigil-Colet, Josefa Canals Sans
The Childhood Autism Spectrum Test (CAST; Scott et al. Autism 2002; 6:9-31) has proved to be a good test for screening autism spectrum disorders (ASD) and social communication problems. This study provides evidence on the statistical properties of the CAST, specifically its validity, factorial structure and discriminative capacity as an ASD screening test, in a Spanish sample of 4-12 year-old children from community and clinical settings. The study concludes that the test was valid and reliable for ASD screening in Spanish clinical and community populations and allowed us to create a new abbreviated version...
April 6, 2017: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/28379373/genetic-and-phenotypic-heterogeneity-suggest-therapeutic-implications-in-scn2a-related-disorders
#15
Markus Wolff, Katrine M Johannesen, Ulrike B S Hedrich, Silvia Masnada, Guido Rubboli, Elena Gardella, Gaetan Lesca, Dorothée Ville, Mathieu Milh, Laurent Villard, Alexandra Afenjar, Sandra Chantot-Bastaraud, Cyril Mignot, Caroline Lardennois, Caroline Nava, Niklas Schwarz, Marion Gérard, Laurence Perrin, Diane Doummar, Stéphane Auvin, Maria J Miranda, Maja Hempel, Eva Brilstra, Nine Knoers, Nienke Verbeek, Marjan van Kempen, Kees P Braun, Grazia Mancini, Saskia Biskup, Konstanze Hörtnagel, Miriam Döcker, Thomas Bast, Tobias Loddenkemper, Lily Wong-Kisiel, Friedrich M Baumeister, Walid Fazeli, Pasquale Striano, Robertino Dilena, Elena Fontana, Federico Zara, Gerhard Kurlemann, Joerg Klepper, Jess G Thoene, Daniel H Arndt, Nicolas Deconinck, Thomas Schmitt-Mechelke, Oliver Maier, Hiltrud Muhle, Beverly Wical, Claudio Finetti, Reinhard Brückner, Joachim Pietz, Günther Golla, Dinesh Jillella, Karen M Linnet, Perrine Charles, Ute Moog, Eve Õiglane-Shlik, John F Mantovani, Kristen Park, Marie Deprez, Damien Lederer, Sandrine Mary, Emmanuel Scalais, Laila Selim, Rudy Van Coster, Lieven Lagae, Marina Nikanorova, Helle Hjalgrim, G Christoph Korenke, Marina Trivisano, Nicola Specchio, Berten Ceulemans, Thomas Dorn, Katherine L Helbig, Katia Hardies, Hannah Stamberger, Peter de Jonghe, Sarah Weckhuysen, Johannes R Lemke, Ingeborg Krägeloh-Mann, Ingo Helbig, Gerhard Kluger, Holger Lerche, Rikke S Møller
Mutations in SCN2A, a gene encoding the voltage-gated sodium channel Nav1.2, have been associated with a spectrum of epilepsies and neurodevelopmental disorders. Here, we report the phenotypes of 71 patients and review 130 previously reported patients. We found that (i) encephalopathies with infantile/childhood onset epilepsies (≥3 months of age) occur almost as often as those with an early infantile onset (<3 months), and are thus more frequent than previously reported; (ii) distinct phenotypes can be seen within the late onset group, including myoclonic-atonic epilepsy (two patients), Lennox-Gastaut not emerging from West syndrome (two patients), and focal epilepsies with an electrical status epilepticus during slow sleep-like EEG pattern (six patients); and (iii) West syndrome constitutes a common phenotype with a major recurring mutation (p...
March 4, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28378271/brief-report-examining-the-association-of-autism-and-adverse-childhood-experiences-in-the-national-survey-of-children-s-health-the-important-role-of-income-and-co-occurring-mental-health-conditions
#16
Connor Morrow Kerns, Craig J Newschaffer, Steven Berkowitz, Brian K Lee
Adverse childhood experiences (ACEs) are risk factors for mental and physical illness and more likely to occur for children with autism spectrum disorder (ASD). The present study aimed to clarify the contribution of poverty, intellectual disability and mental health conditions to this disparity. Data on child and family characteristics, mental health conditions and ACEs were analyzed in 67,067 youth from the 2011-2012 National Survey of Children's Health. In an income-stratified sample, the association of ASD and ACEs was greater for lower income children and significantly diminished after controlling for child mental health conditions, but not intellectual disability...
April 4, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28374929/age-related-differences-in-prevalence-of-autism-spectrum-disorder-symptoms-in-children-and-adolescents-with-costello-syndrome
#17
David D Schwartz, Jennifer M Katzenstein, Eric J Highley, Deborah L Stabley, Katia Sol-Church, Karen W Gripp, Marni E Axelrad
Dysregulation of the mitogen activated protein kinase (MAPK) pathway in Costello syndrome (CS) may contribute to increased risk for autism-spectrum disorder (ASD). We examined prevalence of ASD symptoms in 14 individuals (six females) age 1-18 years with molecularly confirmed CS. Caregivers completed the Modified Checklist for Autism in Toddlers (M-CHAT) for ages 0-4 years (n = 7), and the Social Communication Questionnaire (SCQ) for ages 4 and older (n = 7). Age was associated with meeting ASD criteria: 5/7 (71...
May 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28368272/consensus-statement-of-the-indian-academy-of-pediatrics-on-evaluation-and-management-of-autism-spectrum-disorder
#18
Samir Dalwai, Shabina Ahmed, Vrajesh Udani, Nandini Mundkur, S S Kamath, M K C Nair
JUSTIFICATION: Autism Spectrum Disorder (ASD) is a clinically heterogenous condition with a wide range of etiological factors and causing significant public health burden. ASD poses a serious developmental disadvantage to the child in the form of poor schooling, social function and adult productivity. Thus, framing evidence-based national guidelines is a pressing need. PROCESS: The meeting on formulation of national consensus guidelines on neurodevelopmental disorders was organized by Indian Academy of Paediatrics in Mumbai on 18th and 19th December 2015...
March 29, 2017: Indian Pediatrics
https://www.readbyqxmd.com/read/28367671/the-diagnosis-of-autism-and-autism-spectrum-disorder-in-low-and-middle-income-countries-experience-from-jamaica
#19
Maureen Samms-Vaughan, Mohammad H Rahbar, Aisha S Dickerson, Katherine A Loveland, Manouchehr Hessabi, Deborah A Pearson, Jan Bressler, Sydonnie Shakespeare-Pellington, Megan L Grove, Charlene Coore-Desai, Jody Reece, Eric Boerwinkle
The administration requirements of the Autism Diagnostic Observation Schedule and the Autism Diagnostic Interview-Revised, widely used in high-income countries, make them less feasible for diagnosis of autism spectrum disorder in low- and middle-income countries. The flexible administration requirements of the Childhood Autism Rating Scale have resulted in its use in both high-income countries and low- and middle-income countries. This study examines the agreement between assessments using the Childhood Autism Rating Scale with those using the Autism Diagnostic Observation Schedule or Autism Diagnostic Observation Schedule, Second Edition and Autism Diagnostic Interview-Revised in Jamaica...
March 1, 2017: Autism: the International Journal of Research and Practice
https://www.readbyqxmd.com/read/28357154/vaccine-hesitancy-in-search-of-the-risk-communication-comfort-zone
#20
Joshua Greenberg, Eve Dubé, Michelle Driedger
INTRODUCTION: This paper reports the findings of a national online survey to parents of children aged 5 and younger. The objectives of the study were to assess parental understanding of childhood immunizations, identify sources of information that they trust for vaccine-related content, assess where parents with young children stand on the key issues in the public debate about vaccination, and identify which risk communication messages are most effective for influencing the behaviours of vaccine hesitant parents...
March 3, 2017: PLoS Currents
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