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https://www.readbyqxmd.com/read/29338670/vitamin-a-and-vitamin-d-deficiencies-exacerbate-symptoms-in-children-with-autism-spectrum-disorders
#1
Min Guo, Jiang Zhu, Ting Yang, Xi Lai, Yuxi Lei, Jie Chen, Tingyu Li
OBJECTIVES: This study was designed to investigate the vitamin A (VA) and vitamin D (VD) levels in children with autism spectrum disorders (ASD) and to determine whether co-deficiency of VA and VD exacerbates clinical symptoms in autistic children. METHODS: The Autism Behavior Checklist, Childhood Autism Rating Scale (CARS), and Social Responsiveness Scale (SRS) were used to assess the symptoms of 332 children diagnosed as ASD. And the Gesell Developmental Scale (GDS) was used to evaluate neurodevelopment in children with ASD...
January 16, 2018: Nutritional Neuroscience
https://www.readbyqxmd.com/read/29325234/prospective-associations-between-infant-sleep-at-12-months-and-autism-spectrum-disorder-screening-scores-at-24-months-in-a-community-based-birth-cohort
#2
A K Danny Nguyen, Laura E Murphy, Mehmet Kocak, Frances A Tylavsky, Linda S Pagani
BACKGROUND: Sleep problems have been associated with autism spectrum disorder (ASD) symptoms and diagnosis. However, past research has studied the simultaneous association of sleep problems with precursor ASD symptoms. Using data from a birth cohort, we estimate prospective associations between infant sleep characteristics at 12 months and later ASD screening scores at 24 months. METHODS: We obtained data from children (N = 1,096) and their mothers as participants in the Conditions Affecting Neurocognitive Development and Learning in Early Childhood longitudinal birth cohort study...
January 2, 2018: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29314180/what-s-new-in-atopic-eczema-an-analysis-of-systematic-reviews-published-in-2015-part-1-epidemiology-and-methodology
#3
REVIEW
E Davies, N K Rogers, A Lloyd-Lavery, D J C Grindlay, K S Thomas
This review forms part of a series of annual updates that summarize the evidence base for atopic eczema (AE), providing a succinct guide for clinicians and patients. It provides a summary of key findings from 15 systematic reviews that were published during 2015, and focuses on the epidemiology and methodology issues of AE. For systematic reviews on the prevention and treatment of AE, see Part 2 of this update. The worldwide prevalence of AE during childhood has been calculated to be 7.89% (95% CI 7.88-7.89), based on studies of 1 430 329 children from 102 countries...
January 4, 2018: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/29313176/effectiveness-of-a-multisystem-aquatic-therapy-for-children-with-autism-spectrum-disorders
#4
Giovanni Caputo, Giovanni Ippolito, Marina Mazzotta, Luigi Sentenza, Mara Rosaria Muzio, Sara Salzano, Massimiliano Conson
Aquatic therapy improves motor skills of persons with Autism Spectrum Disorders (ASD), but its usefulness for treating functional difficulties needs to be verified yet. We tested effectiveness of a multisystem aquatic therapy on behavioural, emotional, social and swimming skills of children with ASD. Multisystem aquatic therapy was divided in three phases (emotional adaptation, swimming adaptation and social integration) implemented in a 10-months-programme. At post-treatment, the aquatic therapy group showed significant improvements relative to controls on functional adaptation (Vineland Adaptive Behavior Scales), emotional response, adaptation to change and on activity level (Childhood Autism Rating Scale)...
January 8, 2018: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/29303800/prescribing-trends-of-atypical-antipsychotic-drugs-in-an-outpatient-unit-of-a-child-and-adolescent-clinic-in-turkey
#5
Çiğdem Yektaş, Ali Evren Tufan
OBJECTIVE: Use of antipsychotic agents in the management of various psychopathologies in Child and Adolescent Psychiatric practice is gradually increasing. This study aimed to evaluate the sociodemographic and clinical features of children and adolescents who applied to an outpatient clinic of child and adolescent psychiatry department in Turkey and were prescribed atypical antipsychotics. METHOD: Patients with prescription codes of ATC N05A (except N05AN lithium) were accepted to denote those with atypical antipsychotic treatment...
January 5, 2018: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/29298441/impact-of-auditory-integrative-training-ait-on-transforming-growth-factor-beta-1-tgf-%C3%AE-1-and-its-effect-on-behavioural-and-social-emotions-in-children-with-autism-spectrum-disorder-asd
#6
Laila Al-Ayadhi, Abdulrahman Alhowikan, Dost Halepoto
OBJECTIVE: To explore the impact of auditory integrative training (AIT) on inflammatory biomarker transforming growth factor-β1 (TGF-β1) and to assess its effect on social behaviours in children with autism spectrum disorder (ASD). SUBJECTS AND METHODS: In this cross-sectional study 15 subjects (14 males, I female) with ASD aged 3-12 years were recruited. All subjects were screened for autism by Diagnostic and Statistical Manual of Mental Disorders (DSM-IV). Plasma levels of TGF-β1 in all subjects were measured using sandwich enzyme immunoassay (ELISA) immediately after the AIT sessions and after 1 and 3 months...
January 3, 2018: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/29296085/epilepsy-in-patients-with-autism-links-risks-and-treatment-challenges
#7
REVIEW
Frank Mc Besag
Autism is more common in people with epilepsy, approximately 20%, and epilepsy is more common in people with autism with reported rates of approximately 20%. However, these figures are likely to be affected by the current broader criteria for autism spectrum disorder (ASD), which have contributed to an increased prevalence of autism, with the result that the rate for ASD in epilepsy is likely to be higher and the figure for epilepsy in ASD is likely to be lower. Some evidence suggests that there are two peaks of epilepsy onset in autism, in infancy and adolescence...
2018: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29289663/identification-of-the-antigenic-epitopes-of-maternal-autoantibodies-in-autism-spectrum-disorders
#8
Elizabeth Edmiston, Karen L Jones, Tam Vu, Paul Ashwood, Judy Van de Water
Several groups have described the presence of fetal brain-reactive maternal autoantibodies in the plasma of some mothers whose children have autism spectrum disorder (ASD). We previously identified seven autoantigens targeted by these maternal autoantibodies, each of which is expressed at significant levels in the developing brain and has demonstrated roles in typical neurodevelopment. To further understand the binding repertoire of the maternal autoantibodies, as well as the presence of any meaningful differences with respect to the recognition and binding of these ASD- specific autoantibodies to each of these neuronal autoantigens, we utilized overlapping peptide microarrays incubated with maternal plasma samples obtained from the Childhood Autism Risk from Genetics and Environment (CHARGE) Study...
December 28, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29280230/high-prevalence-of-diabetes-mellitus-hypertension-and-obesity-among-persons-with-a-recorded-diagnosis-of-intellectual-disability-or-autism-spectrum-disorder
#9
E Flygare Wallén, G Ljunggren, A C Carlsson, D Pettersson, P Wändell
BACKGROUND: Obesity and lack of physical activity are frequently reported in persons with intellectual disability (ID) or autism spectrum disorder (ASD). We hypothesised a higher prevalence of diabetes and hypertension in this population. METHOD: We used administrative data for all primary and specialist outpatient and inpatient healthcare consultations for people with at least one recorded diagnosis of diabetes mellitus, hypertension or obesity from 1998 to 2015...
December 26, 2017: Journal of Intellectual Disability Research: JIDR
https://www.readbyqxmd.com/read/29277240/-a-mentalization-based-perspective-on-childhood-autism-treatment
#10
M Thevenet, C Dondé, R Machabert, L Ancona, C Jost, N Georgieff
Mentalization is a process by which a subject makes sense of both his own mental representations and of those around him. Disturbances in the mentalization process are found in several psychiatric disorders, notably borderline personality disorders for which mentalization-based treatments (MBT) have been developed and evaluated. Children with Autism Spectrum Disorder (ASD) display a theory of mind impairments, which corresponds to disturbances in the mentalization process. Although no MBT protocol for patients with ASD has been described in the literature, such treatment appears promising to improve theory of mind and functional outcome of these children...
December 22, 2017: L'Encéphale
https://www.readbyqxmd.com/read/29274201/itraq-based-proteomic-analysis-reveals-protein-profile-in-plasma-from-children-with-autism
#11
Liming Shen, Kaoyuan Zhang, Chengyun Feng, Youjiao Chen, Shuiming Li, Javed Iqbal, Liping Liao, Yuxi Zhao, Jian Zhai
PURPOSE: Autism is a childhood neurological disorder with poorly understood etiology and pathology. This study is designed to identify differentially expressed proteins which might serve as potential biomarkers for autism. EXPERIMENTAL DESIGN: We performed iTRAQ (isobaric tags for relative and absolute quantitation) analysis for normal and autistic children's plasma of the same age group. RESULTS: The results showed that 24 differentially expressed proteins were identified between autistic subjects and controls...
December 23, 2017: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/29262471/-correlation-between-serum-25-hydroxyvitamin-d-level-and-core-symptoms-of-autism-spectrum-disorder-in-children
#12
H Y Dong, B Wang, H H Li, L Shan, F Y Jia
Objective: To explore the relationship between serum 25-hydroxyvitamin D levels and core symptoms of autism spectrum disorder (ASD) in children. Method: In this cross-sectional study, ASD children 4 to 6 years of age who were diagnosed in Department of Developmental and Behavioral Pediatrics, First Hospital of Jilin university from January to May 2017 were assigned to ASD group, and children for routine growth and development assessment in Jilin province were assigned to control group. The two groups were well matched for age and sex, and none of them had received vitamin D supplementation...
December 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/29262469/-association-between-behavioral-problems-and-gastrointestinal-disorders-among-children-with-autism-spectrum-disorder
#13
J Zhu, M Guo, T Yang, X Lai, Y Y Lei, M L He, J Chen, T Y Li
Objective: To investigate the relationship between gastrointestinal disorders (GID) and core symptoms or behavioral problems among the children with autism spectrum disorder (ASD) . Method: Totally 328 children with ASD and 202 normal controls were enrolled in this cross-sectional study from August 2013 to October 2016. The information about the gastrointestinal disorders, behavioral and emotional problems was collected by using questionnaires. Childhood Autism Rating Scale (CARS), Autism Behavior Checklist (ABC) were used to assess the core symptoms of the children with ASD...
December 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/29251836/longitudinal-development-of-thalamic-and-internal-capsule-microstructure-in-autism-spectrum-disorder
#14
Kristine McLaughlin, Brittany G Travers, Olga I Dadalko, Douglas C Dean, Do Tromp, Nagesh Adluru, Daniel Destiche, Abigail Freeman, Molly D Prigge, Alyson Froehlich, Tyler C Duffield, Brandon A Zielinski, Erin D Bigler, Nicholas Lange, Jeff S Anderson, Andrew L Alexander, Janet E Lainhart
The thalamus is a key sensorimotor relay area that is implicated in autism spectrum disorder (ASD). However, it is unknown how the thalamus and white-matter structures that contain thalamo-cortical fiber connections (e.g., the internal capsule) develop from childhood into adulthood and whether this microstructure relates to basic motor challenges in ASD. We used diffusion weighted imaging in a cohort-sequential design to assess longitudinal development of the thalamus, and posterior- and anterior-limbs of the internal capsule (PLIC and ALIC, respectively) in 89 males with ASD and 56 males with typical development (3-41 years; all verbal)...
December 18, 2017: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/29249827/schizophrenia-risk-and-urban-birth-are-associated-with-proteomic-changes-in-neonatal-dried-blood-spots
#15
Jason D Cooper, Sureyya Ozcan, Renee M Gardner, Nitin Rustogi, Susanne Wicks, Geertje F van Rees, F Markus Leweke, Christina Dalman, Håkan Karlsson, Sabine Bahn
In the present study, we tested whether there were proteomic differences in blood between schizophrenia patients after the initial onset of the disorder and controls; and whether those differences were also present at birth among neonates who later developed schizophrenia compared to those without a psychiatric admission. We used multiple reaction monitoring mass spectrometry to quantify 77 proteins (147 peptides) in serum samples from 60 first-onset drug-naive schizophrenia patients and 77 controls, and 96 proteins (152 peptides) in 892 newborn blood-spot (NBS) samples collected between 1975 and 1985...
December 18, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/29248908/international-survey-of-speech-language-pathologists-practices-in-working-with-children-with-autism-spectrum-disorder
#16
Gail Gillon, Yvette Hyter, Fernanda Dreux Fernandes, Sara Ferman, Yvette Hus, Kakia Petinou, Osnat Segal, Tatjana Tumanova, Ioannis Vogindroukas, Carol Westby, Marleen Westerveld
OBJECTIVE: Autism spectrum disorder (ASD) is a complex neurodevelopmental impairment. To better understand the role of speech-language pathologists (SLPs) in different countries in supporting children with ASD, the International Association of Logopedics and Phoniatrics (IALP) Child Language Committee developed a survey for SLPs working with children or adolescents with ASD. Method and Participants: The survey comprised 58 questions about background information of respondents, characteristics of children with ASD, and the role of SLPs in diagnosis, assessment, and intervention practices...
2017: Folia Phoniatrica et Logopaedica
https://www.readbyqxmd.com/read/29241119/bench-to-bedside-review-possible-role-of-vitamin-d-in-autism-spectrum-disorder
#17
REVIEW
Feiyong Jia, Ling Shan, Bing Wang, Honghua Li, Chunyue Miao, Zhida Xu, Ching-Po Lin, Khaled Saad
Autism spectrum disorder (ASD) is a group of dysfunctions in social interaction, communication, and behaviors. Studies have demonstrated that vitamin D deficiency during pregnancy and in individuals increased the risk of ASD. A genetic polymorphism study has pinpointed that genotype AA/A-allele of GC rs4588 in children is associated with ASD, which encodes the vitamin D binding protein. Translating the mentioned points into clinical practice, several clinical trials have demonstrated that vitamin D supplementation can improve the core symptoms in children with ASD...
December 6, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29231773/molecular-imaging-of-autism-spectrum-disorder
#18
Brian Jaeho Hwang, Mona Adel Mohamed, James Robert Brašić
Autism spectrum disorder (ASD) is a condition with onset in early childhood characterized by marked deficits in interpersonal interactions and communication and by a restricted and repetitive range of interests and activities. This review points out key recent findings utilizing molecular imaging including magnetic resonance spectroscopy (MRS) and nuclear neuroimaging techniques such as positron emission tomography (PET) and single-photon emission computed tomography (SPECT). MRS indicates an excitatory/inhibitory imbalance in high-functioning autism...
December 12, 2017: International Review of Psychiatry
https://www.readbyqxmd.com/read/29227523/childhood-ingestions-of-environmental-toxins-what-are-the-risks
#19
Marissa Hauptman, Alan D Woolf
Infants and children are at higher risk than adolescents and adults for exposure to environmental toxins via ingestion for a number of reasons: their smaller size (and proportionately larger dose of ingested toxins), their closer proximity to the ground, dirt, and indoor dust, their boundless curiosity and oral exploratory behaviors, pica habits that may persist into school-age for children with autism or other developmental delays, their proportionately larger daily water and milk intake, and food preferences that differ markedly from adolescents and adults...
December 1, 2017: Pediatric Annals
https://www.readbyqxmd.com/read/29227200/telepsychiatry-for-children-and-adolescents-a-review-of-the-prometted-project
#20
Catherine M Doyen, Marie-Joëlle Oreve, Eric Desailly, Virginie Goupil, Kevin Zarca, Yann L'Hermitte, Pauline Chaste, Marie-Ode Bau, Didier Beaujard, Sliman Haddadi, Ana Bibay, Yves Contejean, Marie-Thérèse Coutrot, Liora Crespin, Isabelle Frioux, Mario Speranza, Nolwenn Francois, Kelley Kaye
BACKGROUND: Telemedicine for children and adolescents is a public health topic, and since 2009 in France, the legal framework defines practical modalities. Some children with Attention Deficit with or without Hyperactivity Disorder, social anxiety, or Autism Spectrum Disorder (ASD) can be easily engaged within a teleconsultation model. Literature suggests new opportunities to facilitate the care process for the ASD person and his family: diagnosis with the use of validated instruments and parental accompaniment...
December 11, 2017: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
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