keyword
MENU ▼
Read by QxMD icon Read
search

USP

keyword
https://www.readbyqxmd.com/read/28062711/snmmi-cor-submits-recommendations-white-paper-on-compounded-sterile-radiopharmaceuticals-to-usp
#1
(no author information available yet)
No abstract text is available yet for this article.
January 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28025484/cross-view-gait-recognition-using-joint-direct-linear-discriminant-analysis
#2
Jose Portillo-Portillo, Roberto Leyva, Victor Sanchez, Gabriel Sanchez-Perez, Hector Perez-Meana, Jesus Olivares-Mercado, Karina Toscano-Medina, Mariko Nakano-Miyatake
This paper proposes a view-invariant gait recognition framework that employs a unique view invariant model that profits from the dimensionality reduction provided by Direct Linear Discriminant Analysis (DLDA). The framework, which employs gait energy images (GEIs), creates a single joint model that accurately classifies GEIs captured at different angles. Moreover, the proposed framework also helps to reduce the under-sampling problem (USP) that usually appears when the number of training samples is much smaller than the dimension of the feature space...
December 22, 2016: Sensors
https://www.readbyqxmd.com/read/28024262/levothyroxine-sodium-revisited-a-wholistic-structural-elucidation-approach-of-new-impurities-via-hplc-hrms-ms-on-line-h-d-exchange-nmr-spectroscopy-and-chemical-synthesis
#3
M Ruggenthaler, J Grass, W Schuh, C G Huber, R J Reischl
The structural elucidation of unknown pharmaceutical impurities plays an important role in the quality control of newly developed and well-established active pharmaceutical ingredients (APIs). The United States Pharmacopeia (USP) monograph for the API Levothyroxine Sodium, a synthetic thyroid hormone, features two high pressure liquid chromatography (HPLC) methods using UV-VIS absorption detection to determine organic impurities in the drug substance. The impurity profile of the first USP method ("Procedure 1") has already been extensively studied, however for the second method ("Procedure 2"), which exhibits a significantly different impurity profile, no wholistic structural elucidation of impurities has been performed yet...
December 14, 2016: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28024259/a-novel-method-for-the-determination-of-chemical-purity-and-assay-of-menaquinone-7-comparison-with-the-methods-from-the-official-usp-monograph
#4
Łukasz Jedynak, Maria Jedynak, Magdalena Kossykowska, Joanna Zagrodzka
An HPLC method with UV detection and separation with the use of a C30 reversed phase analytical column for the determination of chemical purity and assay of menaquinone-7 (MK7) in one chromatographic run was developed. The method is superior to the methods published in the USP Monograph in terms of selectivity, sensitivity and accuracy, as well as time, solvent and sample consumption. The developed methodology was applied to MK7 samples of active pharmaceutical ingredient (API) purity, MK7 samples of lower quality and crude MK7 samples before purification...
December 10, 2016: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28017768/coupling-3d-printing-with-hot-melt-extrusion-to-produce-controlled-release-tablets
#5
Jiaxiang Zhang, Xin Feng, Hemlata Patil, Roshan V Tiwari, Michael A Repka
The main objective of this work was to explore the potential of coupling fused deposition modeling in three-dimensional (3D) printing with hot-melt extrusion (HME) technology to facilitate additive manufacturing, in order to fabricate tablets with enhanced extended release properties. Acetaminophen was used as the model drug and different grades and ratios of polymers were used to formulate tablets. Three-point bending and hardness tests were performed to determine the mechanical properties of the filaments and tablets...
December 22, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28005360/relativistic-prolapse-free-gaussian-basis-sets-of-quadruple-%C3%AE-quality-aug-rpf-4z-iii-the-f-block-elements
#6
Tiago Quevedo Teodoro, Lucas Visscher, Albérico Borges Ferreira da Silva, Roberto Luiz Andrade Haiduke
The f-block elements are addressed in this third part of a series of prolapse-free basis sets of quadruple-ζ quality (RPF-4Z). Relativistic adapted Gaussian basis sets (RAGBSs) are used as primitive sets of functions while correlating/polarization (C/P) functions are chosen by analyzing energy lowerings upon basis set increments in Dirac-Coulomb multireference configuration interaction calculations with single and double excitations of the valence spinors. These function exponents are obtained by applying the RAGBS parameters in a polynomial expression...
January 6, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28004316/denatured-whey-protein-powder-as-a-new-matrix-excipient-design-and-evaluation-of-mucoadhesive-tablets-for-sustained-drug-release-applications
#7
Hassana Hsein, Ghislain Garrait, Fahima Tamani, Eric Beyssac, Valérie Hoffart
PURPOSE: In earlier study, we proposed denatured whey protein (DWP) powder obtained by atomization as a new excipient to promote oral drug delivery. In this work, we evaluate the possibility to formulate tablets based on DWP powders and to characterize their role as a matrix mucoadhesive excipient. METHODS: Tablets containing increased amount of DWP (10 to 30%) were produced by direct compression after mixing with theophylline, microcrystalline cellulose, Aerosil® and magnesium stearate...
December 21, 2016: Pharmaceutical Research
https://www.readbyqxmd.com/read/27999174/the-histone-deubiquitinase-otld1-targets-euchromatin-to-regulate-plant-growth
#8
Ido Keren, Vitaly Citovsky
Histone monoubiquitination is associated with active chromatin and plays an important role in epigenetic regulation of gene expression in plants. Deubiquitinating enzymes remove the ubiquitin group from histones and thereby contribute to gene repression. The Arabidopsis thaliana genome encodes 50 deubiquitinases, yet only 2 of them-UBP26 and OTLD1, members of the USP/UBP (ubiquitin-specific protease and ubiquitin-binding protein) and OTU (ovarian tumor protease) deubiquitinase families-are known to target histones...
December 20, 2016: Science Signaling
https://www.readbyqxmd.com/read/27996302/determination-of-interference-during-in-vitro-pyrogen-detection-development-and-characterization-of-a-cell-based-assay
#9
Linda Palma, Francesca Rossetti, Sabrina Dominici, Costantina Buondelmonte, Marco B L Rocchi, Gian P Rizzardi, Giuliana Vallanti, Mauro Magnani
Contamination of pharmaceutical products and medical devices with pyrogens such as endotoxins is the most common cause of systemic inflammation and, in worst cases, of septic shock. Thus, quantification of pyrogens is crucial. The limulus amebocyte lysate (LAL)-based assays are the reference tests for in vitro endotoxin detection, in association with the in vivo rabbit pyrogen test (RPT), according to European Pharmacopoeia (EP 2.6.14), and U.S. Pharmacopoeia (USP <85>). However, several substances interfere with LAL assay, while RPT is not accurate, not quantitative, and raises ethical limits...
December 20, 2016: Assay and Drug Development Technologies
https://www.readbyqxmd.com/read/27993701/comprehensive-expression-analysis-of-pathogenicity-genes-in-uropathogenic-escherichia-coli-strains
#10
Gloria Luz Paniagua-Contreras, Tania Hernández-Jaimes, Eric Monroy-Pérez, Felipe Vaca-Paniagua, Clara Díaz-Velásquez, Alina Uribe-García, Sergio Vaca
In this study, we investigated distinct expression patterns of genes encoding iron-acquisition systems, adhesins, protectins, and toxins in human uroepithelial cells infected with 194 uropathogenic Escherichia coli (UPEC) strains in vitro. We assessed the association of these genes with antibiotic resistance genes in this group of UPEC strains, previously characterised by polymerase chain reaction (PCR). Strains were isolated from patients with urinary tract infections (UTIs) from Unidad Médica Familiar de Salud Pública, located in Estado de México, México...
December 18, 2016: Microbial Pathogenesis
https://www.readbyqxmd.com/read/27983619/rna-interference-of-the-ecdysone-receptor-genes-ecr-and-usp-in-grain-aphid-sitobion-avenae-f-affects-its-survival-and-fecundity-upon-feeding-on-wheat-plants
#11
Ting Yan, Hongmei Chen, Yongwei Sun, Xiudao Yu, Lanqin Xia
RNA interference (RNAi) has been widely used in functional genomics of insects and received intensive attention in the development of RNAi-based plants for insect control. Ecdysone receptor (EcR) and ultraspiracle protein (USP) play important roles in molting, metamorphosis, and reproduction of insects. EcR and USP orthologs and their function in grain aphid (Sitobion avenae F.) have not been documented yet. Here, RT-PCR, qRT-PCR, dsRNA feeding assay and aphid bioassay were employed to isolate EcR and USP orthologs in grain aphid, investigate their expression patterns, and evaluate the effect of RNAi on aphid survival and fecundity, and its persistence...
December 14, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27974592/dose-uniformity-of-scored-and-unscored-tablets-application-of-the-fda-tablet-scoring-guidance-for-industry
#12
Anthony B Ciavarella, Mansoor A Khan, Abhay Gupta, Patrick J Faustino
PURPOSE: This U.S. Food and Drug Administration (FDA) laboratory study examines the impact of tablet splitting, the effect of tablet splitters, and the presence of a tablet score on the dose uniformity of two model drugs. METHODS: Whole tablets were purchased from five manufacturers for amlodipine and six for gabapentin. Two splitters were used for each drug product, and the gabapentin tablets were also split by hand. Whole and split amlodipine tablets were tested for content uniformity following the general chapter of the United States Pharmacopeia (USP) Uniformity of Dosage Units <905>, which is a requirement of the new FDA Guidance for Industry on tablet scoring...
November 2016: PDA Journal of Pharmaceutical Science and Technology
https://www.readbyqxmd.com/read/27906611/on-evaluation-of-reliability-repeatability-and-reproducibility-of-instrumental-evaluation-methods-and-measurement-systems
#13
Samir Salah, Shein-Chung Chow, Fuyu Song
Validation of instrumental evaluation methods or measurement systems plays an important role in both pharmaceutical and cosmetic research and development. In practice, it is suggested that validation should be done according to performance characteristics as described in the United States Pharmacopedia and National Formulary (USP/NF, 2000) for analytical methods validation. A validated method or measurement system is expected to achieve a certain degree of accuracy and reliability. However, it is a concern whether the test results obtained are repeatable (with similar test samples) and/or reproducible (under similar but slightly different experimental conditions)...
December 1, 2016: Journal of Biopharmaceutical Statistics
https://www.readbyqxmd.com/read/27900836/spectrofluorimetric-determination-of-certain-adrenergic-agonist-drugs-in-their-pure-forms-and-pharmaceutical-formulations-content-uniformity-test-application
#14
Khalid M Badr El-Din, Tamer Z Attia
A new, simple, sensitive and rapid spectrofluorimetric method has been developed for determination of certain adrenergic agonists such as isoxsuprine hydrochloride, ritodrine hydrochloride and etilefrine hydrochloride in their pure forms and pharmaceutical dosage forms. The method depends on micellar enhancement of the native fluorescence of investigated drugs by using 2% w/v sodium dodecyl sulfate (SDS) as an anionic surfactant. The enhanced fluorescence intensity of investigated drugs was measured at 305 nm after excitation at 278 nm...
November 29, 2016: Luminescence: the Journal of Biological and Chemical Luminescence
https://www.readbyqxmd.com/read/27899535/a-universal-stress-protein-involved-in-oxidative-stress-is-a-phosphorylation-target-for-protein-kinase-cipk6
#15
Emilio Gutiérrez-Beltrán, José María Personat, Fernando de la Torre, Olga Del Pozo
Calcineurin B-like interacting protein kinases (CIPKs) decode calcium signals upon interaction with the calcium sensors calcineurin B like proteins into phosphorylation events that result into adaptation to environmental stresses. Few phosphorylation targets of CIPKs are known and therefore the molecular mechanisms underlying their downstream output responses are not fully understood. Tomato (Solanum lycopersicum) Cipk6 regulates immune and susceptible Programmed cell death in immunity transforming Ca(2+) signals into reactive oxygen species (ROS) signaling...
January 2017: Plant Physiology
https://www.readbyqxmd.com/read/27895634/cytosolic-proteome-profiling-of-aminoglycosides-resistant-mycobacterium-tuberculosis-clinical-isolates-using-maldi-tof-ms
#16
Divakar Sharma, Manju Lata, Rananjay Singh, Nirmala Deo, Krishnamurthy Venkatesan, Deepa Bisht
Emergence of extensively drug resistant tuberculosis (XDR-TB) is the consequence of the failure of second line TB treatment. Aminoglycosides are the important second line anti-TB drugs used to treat the multi drug resistant tuberculosis (MDR-TB). Main known mechanism of action of aminoglycosides is to inhibit the protein synthesis by inhibiting the normal functioning of ribosome. Primary target of aminoglycosides are the ribosomal RNA and its associated proteins. Various mechanisms have been proposed for aminoglycosides resistance but still some are unsolved...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27894560/analysis-of-temperature-variability-in-medication-storage-compartments-in-emergency-transport-helicopters
#17
Margaret A O'Donnell, Justin Whitfield
The purpose of this study was to determine whether the temperature in medication storage compartments in air medical helicopters was within United States Pharmacopeia (USP)-defined limits for controlled room temperature. This was a prospective study using data obtained from a continuous temperature monitoring device. A total of 4 monitors were placed within 2 medication storage locations in 2 identical helicopters. The data collection period lasted 2 weeks during the summer and winter seasons. Data retrieved from monitors were compared against USP parameters for proper medication storage...
November 2016: Air Medical Journal
https://www.readbyqxmd.com/read/27890717/ecdysone-receptor-ecr-and-ultraspiracle-usp-genes-from-the-cyclopoid-copepod-paracyclopina-nana-identification-and-expression-in-response-to-water-accommodated-fractions-wafs
#18
Jayesh Puthumana, Min-Chul Lee, Jeonghoon Han, Hui-Su Kim, Dae-Sik Hwang, Jae-Seong Lee
Ecdysteroid hormones are pivotal in the development, growth, and molting of arthropods, and the hormone pathway is triggered by binding ecdysteroid to a heterodimer of the two nuclear receptors; ecdysone receptors (EcR) and ultraspiracle (USP). We have characterized EcR and USP genes, and their 5'-untranslated region (5'-UTR) from the copepod Paracyclopina nana, and studied mRNA transcription levels in post-embryonic stages and in response to water accommodated fractions (WAFs) of crude oil. The open reading frames (ORF) of EcR and USP were 1470 and 1287bp that encoded 490 and 429 amino acids with molecular weight of 121...
February 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/27890577/transcription-factors-regulating-uspa-genes-in-catharanthus%C3%A2-roseus
#19
Ahmed Bahieldin, Ahmed Atef, Ahmed M Shokry, Saleh Al-Karim, Sanaa G Al Attas, Nour O Gadallah, Sherif Edris, Magdy A Al-Kordy, Sabah M Hassan, Salah Abo-Aba, Fotouh M El-Domyati
RNA-Seq of the Catharanthus roseus SRA database was done in order to detect putative universal stress proteins (USPs) and their possible controlling factors. Previous analysis indicated the existence and characterization of uspA-like genes. In silico analysis of RNA-Seq database in several plant tissues revealed the possible functions and regulations of some uspA-like transcripts whose transcription factors (TFs) that might drive their expression were detected. BLAST indicated the existence of TF superfamilies erf (ethylene-responsive TF), bHLH (basic helix-loop-helix) and WRKY that might regulate several uspA-like genes...
November 24, 2016: Comptes Rendus Biologies
https://www.readbyqxmd.com/read/27887889/development-of-intramammary-drug-delivery-systems-novel-in%C3%A2-vitro-release-method
#20
Sanjay Garg, Wen Wang, Yunmei Song, Patricia Eats, Darren J Trott, Stephen W Page, Kiro R Petrovski
The aim of this study was to develop an in vitro release model for intramammary drug delivery system (IMDS) evaluation. This study was the first to establish an in vitro-in vivo correlation with investigation of an IMDS containing lasalocid. Three different methods including the standard United States Pharmacopeia dissolution method with apparatus 2, a modified United States Pharmacopeia method using a dialysis bag, or a specifically designed enhancer cell system, were assessed for the release study. Full cream milk and water were selected as the release media...
November 23, 2016: Journal of Pharmaceutical Sciences
keyword
keyword
85018
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"