keyword
MENU ▼
Read by QxMD icon Read
search

USP

keyword
https://www.readbyqxmd.com/read/29783036/retrospective-study-on-the-management-and-follow-up-of-18-patients-with-a-mid-urethral-sling-penetrating-the-urethra-or-bladder
#1
Edouard Goujon, Adélaide Jarniat, Florian Bardet, Lise Bergogne, Emmanuel Delorme
INTRODUCTION: The mid-urethral sling (MUS) procedure is the gold-standard for the surgical treatment of stress urinary incontinence (SUI). Urethro-vesical sling exposure is one of the most serious complications of this procedure. We describe the treatment and follow-up of 18 patients with bladder or urethral sling exposure. PATIENTS AND METHODS: This single-center, retrospective study assessed the diagnosis and management of MUS penetrating the lower urinary tract in 18 women...
May 18, 2018: Journal of Gynecology Obstetrics and Human Reproduction
https://www.readbyqxmd.com/read/29779149/an-invitation-to-travel-in-an-interethnic-arena-listening-carefully-to-amerindian-leaders-speeches
#2
Rafaela Waddington Achatz, Danilo Silva Guimarães
In this article, we identify usual difficulties faced by Brazilian psychologists when dealing with Amerindian Peoples, concerning the systematic violence experienced by those Peoples, who have been suffering and fighting against a process of genocide and ethnocide. To identify those difficulties, we analysed speeches of Amerindian leaders of the State of São Paulo - Guarani Mbya, Pankararu, Xavante, Baniwa, Tupi - Guarani, Terena, Kaingang and Krenak - which were addressed to psychologists. Those speeches were delivered in events promoted by CRP-SP in 2010 and in the 2nd and 3rd Forums "The Amerindian presence in São Paulo" at the Institute of Psychology (USP), in 2014...
May 19, 2018: Integrative Psychological & Behavioral Science
https://www.readbyqxmd.com/read/29779109/the-gene-encoding-the-universal-stress-protein-atusp-is-regulated-by-phytohormones-and-involved-in-seed-germination-of-arabidopsis-thaliana
#3
D S Gorshkova, I A Getman, A S Voronkov, S I Chizhova, Vl V Kuznetsov, E S Pojidaeva
For the first time, the organ-specific expression pattern of the AtUSP (At3g58450) gene, which also undergoes hormonal regulation, was shown. The USP protein encoded by this gene is involved in seed germination of Arabidopsis thaliana and, unlike abscisic acid, stimulates this process.
March 2018: Doklady. Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29778318/quality-specifications-for-articles-of-botanical-origin-from-the-united-states-pharmacopeia
#4
Cuiying Ma, Hellen Oketch-Rabah, Nam-Cheol Kim, Maria Monagas, Anton Bzhelyansky, Nandakumara Sarma, Gabriel Giancaspro
BACKGROUND: In order to define appropriate quality of botanical dietary supplements, botanical drugs, and herbal medicines, the United States Pharmacopeia (USP) and the Herbal Medicines Compendium (HMC) contain science-based quality standards that include multiple interrelated tests to provide a full quality characterization for each article in terms of its identity, purity, and content. PURPOSE: To provide a comprehensive description of the pharmacopeial tests and requirements for articles of botanical origin in the aforementioned compendia...
April 10, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29775759/-938-rhrk-941-is-responsible-for-ubiquitin-specific-protease-48-nuclear-translocation-which-can-stabilize-nf-%C3%AE%C2%BAb-p65-in-the-nucleus
#5
Ying-Li Liu, Jing Yan, Jie Zheng, Qing-Bao Tian
The transcription factor NF-κB is a key regulator of cellular processes. A mechanism that contributes to timely termination of NF-κB activity is UPS-dependent degradation of p65 in the nucleus or on chromatin. The ubiquitin-specific protease that takes part in this process and its molecular mechanisms are shown in previous study, but which structural feature of USP48 was responsible for these effects is unknown. Here, we show that maybe the stability of NF-κB is controlled by proteasome-mediated degradation and ubiquitin-specific protease 48 (USP48), also known as synaptic ubiquitin-specific protease (synUSP) or USP31, can enhance NF-κB stability through proteasome-dependent regulation in the nucleus...
May 15, 2018: Gene
https://www.readbyqxmd.com/read/29771308/what-do-older-people-do-when-sitting-and-why-implications-for-decreasing-sedentary-behavior
#6
Victoria J Palmer, Cindy M Gray, Claire F Fitzsimons, Nanette Mutrie, Sally Wyke, Ian J Deary, Geoff Der, Sebastien F M Chastin, Dawn A Skelton
Background and Objectives: Sitting less can reduce older adults' risk of ill health and disability. Effective sedentary behavior interventions require greater understanding of what older adults do when sitting (and not sitting), and why. This study compares the types, context, and role of sitting activities in the daily lives of older men and women who sit more or less than average. Research Design and Methods: Semistructured interviews with 44 older men and women of different ages, socioeconomic status, and objectively measured sedentary behavior were analyzed using social practice theory to explore the multifactorial, inter-relational influences on their sedentary behavior...
May 15, 2018: Gerontologist
https://www.readbyqxmd.com/read/29768507/attitudes-to-ageing-and-objectively-measured-sedentary-and-walking-behaviour-in-older-people-the-lothian-birth-cohort-1936
#7
Catharine R Gale, Iva Čukić, Sebastien F Chastin, Philippa M Dall, Manon L Dontje, Dawn A Skelton, Ian J Deary
BACKGROUND: Prolonged sitting and low activity-both common in older people-are associated with increased mortality and poorer health. Whether having a more negative attitude to ageing is associated with higher levels of these behaviours is unclear. OBJECTIVE: We investigated the prospective relationship between attitudes to ageing and objectively measured sedentary and walking behaviour. METHODS: Participants were 271 members of the Lothian Birth Cohort 1936...
2018: PloS One
https://www.readbyqxmd.com/read/29760915/onsite-production-of-medical-air-is-purity-a-problem
#8
Paul Edwards, Patricia-Ann Therriault, Ira Katz
Introduction: Medical air (MA) is widely used in hospitals, often manufactured onsite by compressing external ambient air and supplied through a local network piping system. Onsite production gives rise to a risk of impurities that are governed by the same pharmacopoeia purity standards applicable to commercially produced MA. The question to be addressed in this paper is how to assess if a lack of purity poses a medical problem? Methods: The MA produced onsite at a major Canadian hospital was monitored for carbon dioxide (CO2 ) and other impurity gases at high frequency (one per minute) over a two-month period...
2018: Multidisciplinary Respiratory Medicine
https://www.readbyqxmd.com/read/29758033/phylogenetic-relationships-biofilm-formation-motility-antibiotic-resistance-and-extended-virulence-genotypes-among-escherichia-coli-strains-from-women-with-community-onset-primitive-acute-pyelonephritis
#9
Arianna Pompilio, Valentina Crocetta, Vincenzo Savini, Dezemona Petrelli, Marta Di Nicola, Silvia Bucco, Luigi Amoroso, Mario Bonomini, Giovanni Di Bonaventura
The present work set out to search for a virulence repertoire distinctive for Escherichia coli causing primitive acute pyelonephritis (APN). To this end, the virulence potential of 18 E. coli APN strains was genotypically and phenotypically assessed, comparatively with 19 strains causing recurrent cystitis (RC), and 16 clinically not significant (control, CO) strains. Most of the strains belong to phylogenetic group B1 (69.8%; p<0.01), and APN strains showed unique features, which are the presence of phylogroup A, and the absence of phylogroup B2 and non-typeable strains...
2018: PloS One
https://www.readbyqxmd.com/read/29757661/a-pivotal-field-study-to-support-the-registration-of-levothyroxine-sodium-tablets-for-canine-hypothyroidism
#10
Victoria A Lewis, Carla M K Morrow, Johnny A Jacobsen, W Eugene Lloyd
A prospective, pivotal, multicenter field study to evaluate the dose regimen, effectiveness, and safety of levothyroxine sodium tablets, USP for the treatment of hypothyroidism and hypothyroidism-associated clinical signs in dogs was conducted. Ninety-two dogs diagnosed with primary hypothyroidism met the entrance criteria and were enrolled into the study. Levothyroxine sodium was administered to each dog on a daily basis either as the whole dose q 24 hr or as half the dose q 12 hr. Dosing started at 0.1 mg/10 lb (0...
May 14, 2018: Journal of the American Animal Hospital Association
https://www.readbyqxmd.com/read/29754067/enantiomeric-impurity-analysis-using-circular-dichroism-spectroscopy-with-united-states-pharmacopeia-liquid-chromatographic-methods
#11
Douglas Kirkpatrick, Margaret Fain, Jingyue Yang, Michael Trehy
Over 300 chiral drug substances lack official United States Pharmacopeia (USP) methods for the enantiomeric purity determination. Because enantiomeric analysis typically requires specialized methods for each drug compound, developing protocols for each of these 300+ substances would be an expensive and laborious endeavor. Alternatively, if a detector capable of determining the enantiomeric composition without chiral separation could be used with certain drug compounds, this could be implemented relatively rapidly into official testing monographs...
April 24, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29749454/usp18-promotes-breast-cancer-growth-by-upregulating-egfr-and-activating-the-akt-skp2-pathway
#12
Yawen Tan, Guanglin Zhou, Xianming Wang, Weicai Chen, Haidong Gao
Recent studies have suggested that ubiquitin-specific peptidase (USP)18 may act as an oncogene in various types of cancer. Although the role of USP18 in breast cancer cell lines has been elucidated, the underlying mechanisms and clinical role of USP18 in breast cancer are currently not well understood. The bioinformatics analysis and experimental results of the present study demonstrated that aberrant promoter methylation led to increased expression of USP18 in breast cancer. In addition, correlation analysis suggested that a negative correlation between methylation and USP18 mRNA expression was observed in The Cancer Genome Atlas database...
April 30, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29746133/in-vitro-dissolution-as-a-tool-for-formulation-selection-telmisartan-two-step-ivivc
#13
Alejandro Ruiz-Picazo, Mª Teresa Martinez-Martinez, Sarin Colon-Useche, Ramon Iriarte, Barbara Sanchez-Dengra, Marta Gonzalez-Alvarez, Alfredo Garcia-Arieta, Isabel Gonzalez Alvarez, Marival Bermejo
The main objective of this investigation was to develop an exploratory two-step level A IVIVC for three Telmisartan oral immediate release formulations, the reference product Micardis and two generic formulations (X1 and X2). Correlation was validated with a third test formulation Y1. Experimental solubility and permeability data was obtained to confirm that Telmisartan is a class II compound under the Biopharmaceutic Classification System. BE studies plasma profiles were combined using a previously published reference scaling procedure...
May 10, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29737796/pancreatic-enzyme-replacement-therapy-pert-in-children-with-persistent-diarrhea-avoidance-of-elemental-diet-need-accessibility-and-costs
#14
Ariani Dewi Widodo, Rianto Setiabudy, Ina S Timan, Saptawati Bardosono, Widdy Winarta, Agus Firmansyah
BACKGROUND AND OBJECTIVES: Persistent diarrhea has been proven to cause pancreatic exocrine insufficiency, due to decreased stimulation to the pancreas caused by prolonged mucosal injury. Pancreatic enzyme replacement therapy (PERT) given in conjunction to regular treatment is thought to be beneficial in replacing this pancreatic enzyme deficiency, avoiding the need of elemental diet. This study aims to evaluate the benefit of PERT in chil-dren with persistent diarrhea. METHODS AND STUDY DESIGN: This is a randomized, two double-blind parallel group, placebo-controlled clinical trial to evaluate the effects of pancreatic enzyme supplementation in persistent diar-rhea...
2018: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29736887/transfer-behavior-of-the-weakly-acidic-bcs-class-ii-drug-valsartan-from-the-stomach-to-the-small-intestine-during-fasted-and-fed-states
#15
Rania Hamed, Sabreen Hasan Alnadi
The objective of this study was to investigate the transfer behavior of the weakly acidic BCS class II drug valsartan from the stomach to the small intestine during fasted and fed states. An in vitro transfer model previously introduced by Kostewicz et al. (J Pharm Pharmacol 56(1):43-51, 2004) based on a syringe pump and a USP paddle apparatus was used to determine the concentration profiles of valsartan in the small intestine. Donor phases of simulated gastric fluid during fasted (FaSSGF) and fed (FeSSGF) states were used to predisperse Diovan® tablets (160 mg valsartan)...
May 7, 2018: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29736295/structural-confirmation-of-sulconazole-sulfoxide-as-the-primary-degradation-product-of-sulconazole-nitrate
#16
Qun Xu, Ashraf Khan, Di Gao, Kristie M Adams, Fatkhulla Tadjimukhamedov, Shane Tan, John T Simpson
Sulconazole has been reported to degrade into sulconazole sulfoxide via sulfur oxidation; however, structural characterization data was lacking and the potential formation of an N -oxide or sulfone could not be excluded. To clarify the degradation pathways and incorporate the impurity profile of sulconazole into the United States Pharmacopeia-National Formulary ( USP-NF ) monographs, a multifaceted approach was utilized to confirm the identity of the degradant. The approach combines stress testing of sulconazole nitrate, chemical synthesis of the degradant via a hydrogen peroxide-mediated oxidation reaction, semi-preparative HPLC purification, and structural elucidation by LC-MS/MS and NMR spectroscopy...
April 2018: Journal of Pharmaceutical Analysis
https://www.readbyqxmd.com/read/29722897/mucopolysaccharidosis-vi-and-effects-on-growth-of-the-apical-bases-a-case-report
#17
Moema Ferreira Dos Reis, Lucas Rodrigues Pinheiro, Maria das Graças Rodrigues Pinheiro, Haroldo Amorim de Almeida, Patrícia do Socorro Queiroz Feio, Sâmia Cordovil de Almeida, Isabel Cristina Neves de Souza, Roberto Giugliani, Ida Vanessa Doederlein Schwartz, Rosely Maria Dos Santos Cavaleiro, João de Jesus Viana Pinheiro, Luiz Carlos Santana da Silva
OBJECTIVE: Mucopolysaccharidosis (MPS) VI is a rare disorder caused by an autosomal recessive mutation in the short arm of chromosome 5 (5q12-13) leading to an N-acetylgalactosamine-sulfatase lysosomal enzyme deficiency and numerous systemic clinical changes. The oral and maxillofacial complex may exhibit tooth eruption anomalies, macroglossia, gingival hypertrophy, mouth breathing, increased lower facial height, open bite, retrognathia, and progressive TMJ arthrosis. This report describes craniofacial growth changes in two MPS VI patients, sisters and daughters of outbred parents, who were longitudinally monitored from 11 to 15 years of age...
May 3, 2018: Special Care in Dentistry
https://www.readbyqxmd.com/read/29698567/ubiquitin-specific-peptidase-10-usp10-inhibits-hepatic-steatosis-insulin-resistance-and-inflammation-via-sirt6
#18
Pengcheng Luo, Cong Qin, Lihua Zhu, Chun Fang, Yan Zhang, Hai Zhang, Fei Pei, Song Tian, Xue-Yong Zhu, Gong Jun, Qing Mao, Chengcheng Xiao, Yang Su, Haizhou Zheng, Tao Xu, Jingxiao Lu, Jie Zhang
BACKGROUND AND AIMS: Nonalcoholic fatty liver disease (NAFLD) is characterized by hepatic steatosis, insulin resistance and inflammation, and the pathogenic mechanism of NAFLD is poorly understood. Ubiquitin-specific peptidase 10 (USP10), a member of the ubiquitin-specific protease (USP) family, is involved in environmental stress responses, tumor growth, inflammation and cellular metabolism. However, the role of USP10 in hepatic steatosis, insulin resistance and inflammation remains largely unexplored...
April 26, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29692798/the-presence-of-genotoxic-and-or-pro-inflammatory-bacterial-genes-in-gut-metagenomic-databases-and-their-possible-link-with-inflammatory-bowel-diseases
#19
Abiel Roche-Lima, Kelvin Carrasquillo-Carrión, Ramón Gómez-Moreno, Juan M Cruz, Dayanara M Velázquez-Morales, Igor B Rogozin, Abel Baerga-Ortiz
Background: The human gut microbiota is a dynamic community of microorganisms that mediate important biochemical processes. Differences in the gut microbial composition have been associated with inflammatory bowel diseases (IBD) and other intestinal disorders. In this study, we quantified and compared the frequencies of eight genotoxic and/or pro-inflammatory bacterial genes found in metagenomic Whole Genome Sequences (mWGSs) of samples from individuals with IBD vs. a cohort of healthy human subjects. Methods: The eight selected gene sequences were clbN, clbB, cif, cnf-1, usp, tcpC from Escherichia coli, gelE from Enterococcus faecalis and murB from Akkermansia muciniphila ...
2018: Frontiers in Genetics
https://www.readbyqxmd.com/read/29689370/dissolution-of-fine-particle-fraction-from-truncated-anderson-cascade-impactor-with-an-enhancer-cell
#20
Justin Yong Soon Tay, Celine Valeria Liew, Paul Wan Sia Heng
Dissolution testing for inhalers were previously conducted either on unfractionated drug-carrier powders or drug of specific aerodynamic particle size. In this study, the collection of the full fine particle fraction (FPF) was attempted on a single stage. Capsules containing 30 mg of 2% salbutamol sulfate (SS) was tested to have a FPF of 9 ± 1% using the full set of Andersen cascade impactor (ACI) and a modified Rotahaler® capable of achieving 4.0 kPa pressure drop at 60 L/min air flow rate. A truncated ACI comprising the USP throat, pre-separator, stage 0, stage 4, stage F, polytetrafluoroethylene funnel (TF) and small collection plate (sCP) was found to be capable of achieving a FPF of 9% collected on TF and sCP...
April 21, 2018: International Journal of Pharmaceutics
keyword
keyword
85018
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"