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https://www.readbyqxmd.com/read/29333787/detection-of-ureaplasma-species-by-a-semi-quantitative-pcr-test-in-urine-samples-can-it-predict-clinical-significance
#1
Merav Strauss, Raul Colodner, Dana Sagas, Azmi Adawi, Hanna Edelstein, Bibiana Chazan
BACKGROUND: Ureaplasma species (Usp) are the most prevalent genital Mycoplasma isolated from the urogenital tract of both men and women. Usp may be commensals in the genital tract but may also be contributors to a number of pathological conditions of the genital tract. Because they can also just colonize the genital tract of healthy people, their pathogenic role can be difficult to prove. OBJECTIVES: The aim of the study was to evaluate the efficacy of a quantitative polymerase chain reaction (qPCR) method for the discrimination between infection and colonization by measuring prevalence of Usp in asymptomatic versus symptomatic patients...
January 2018: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/29332254/comparison-of-adjustable-continence-therapy-periurethral-balloons-and-artificial-urinary-sphincter-in-female-patients-with-stress-urinary-incontinence-due-to-intrinsic-sphincter-deficiency
#2
Lucas Freton, Lauranne Tondut, Isabelle Enderle, Juliette Hascoet, Andrea Manunta, Benoit Peyronnet
INTRODUCTION AND HYPOTHESIS: The objective was to compare the outcomes of the ACT® device with those of the artificial urinary sphincter (AUS) AMS 800 in the treatment of stress urinary incontinence (SUI) due to sphincter deficiency in women. METHODS: All the women who underwent surgical treatment for SUI due to intrinsic sphincter deficiency from 2007 to 2017 were included in a single-center retrospective study. The primary endpoint was the functional outcome...
January 13, 2018: International Urogynecology Journal
https://www.readbyqxmd.com/read/29327292/alterations-of-growth-rate-and-gene-expression-levels-of-upec-by-antibiotics-at-sub-mic
#3
Defne Gümüş, Fatma Kalaycı-Yüksek, Emre Yörük, Gülşen Uz, Eşref Çelik, Cansu Arslan, Elif Merve Aydın, Cem Canlı, Mine Anğ-Küçüker
The host is the main environment for bacteria, and they also expose to many antibiotics during the treatment of infectious diseases in host body. In this study, it was aimed to investigate possible changes in growth rate and expression levels of three virulence genes (foc/foc, cnf1, and usp) in a uropathogenic E. coli standard strain within the presence of ciprofloxacin, nitrofurantoin, and trimethoprim-sulfamethoxazole. The UPEC C7 strain was grown on tryptic soy broth-TSB (control), TSB + ciprofloxacin, TSB + nitrofurantoin, and TSB + trimethoprim-sulfamethoxazole for determination of both growth rate and gene expression level...
January 11, 2018: Folia Microbiologica
https://www.readbyqxmd.com/read/29321814/the-epigenetic-clock-and-objectively-measured-sedentary-and-walking-behavior-in-older-adults-the-lothian-birth-cohort-1936
#4
Catharine R Gale, Riccardo E Marioni, Iva Čukić, Sebastien F Chastin, Philippa M Dall, Manon L Dontje, Dawn A Skelton, Ian J Deary
Background: Estimates of biological age derived from DNA-methylation patterns-known as the epigenetic clock-are associated with mortality, physical and cognitive function, and frailty, but little is known about their relationship with sedentary behavior or physical activity. We investigated the cross-sectional relationship between two such estimates of biological age and objectively measured sedentary and walking behavior in older people. Methods: Participants were 248 members of the Lothian Birth Cohort 1936...
2018: Clinical Epigenetics
https://www.readbyqxmd.com/read/29319719/a-new-low-cost-negative-pressure-wound-therapy-versus-a-commercially-available-therapy-device-widely-used-to-treat-complex-traumatic-injuries-a-prospective-randomized-non-inferiority-trial
#5
Fabio Kamamoto, Ana Lucia Munhoz Lima, Marcelo Rosa de Rezende, Rames Mattar-Junior, Marcos de Camargo Leonhardt, Kodi Edson Kojima, Carla Chineze Dos Santos
OBJECTIVES: Negative-pressure wound therapy has been widely adopted to reduce the complexity of treating a broad range of acute and chronic wounds. However, its cost is high. The objective of this study was to evaluate the following two different methods of negative-pressure wound therapy in terms of healing time: a low-cost method of negative-pressure wound therapy (a pressure stabilizer device connected to a hospital wall-vacuum system with a gauze-sealed dressing, USP) and the standard of care (vacuum-assisted closure, VAC)...
December 2017: Clinics
https://www.readbyqxmd.com/read/29317274/skin-corrosion-test-comparison-between-reconstructed-human-epidermis-and-full-thickness-skin-models
#6
Carolina Motter Catarino, Tatiana do Nascimento Pedrosa, Paula Comune Pennacchi, Silvia Romano de Assis, Fabrícia Gimenes, Márcia Edilaine Lopes Consolaro, Silvia Berlanga de Moraes Barros, Silvya Stuchi Maria-Enlger
Currently, there is a strong global trend towards the development of in vitro models to replace the use of animals in safety evaluation tests. Reconstructed Human Epidermis (RHE) models have been employed as an alternative method to animal testing of skin corrosion and irritation potential of chemical compounds. However, the consequences of an absence of the dermal compartment in these models should be considered since the cross-talk between fibroblasts and keratinocytes is fundamental for promoting proper epidermal stratification, homeostasis, inflammatory response and wound healing...
January 6, 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29311232/context-dependent-requirements-for-fimh-and-other-canonical-virulence-factors-in-gut-colonization-by-extraintestinal-pathogenic-escherichia-coli
#7
Colin W Russell, Brittany A Fleming, Courtney A Jost, Alexander Tran, Alan T Stenquist, Morgan A Wambaugh, Mary P Bronner, Matthew A Mulvey
Extraintestinal pathogenic Escherichia coli (ExPEC) act as commensals within the mammalian gut, but can induce pathology upon dissemination to other host environments such as the urinary tract and bloodstream. ExPEC genomes are likely shaped by evolutionary forces encountered within the gut where the bacteria spend much of their time, provoking the question of how their extraintestinal virulence traits arose. The principle of coincidental evolution, in which a gene that evolved in one niche happens to be advantageous in another, has been used to argue that ExPEC virulence factors originated in response to selective pressures within the gut ecosystem...
January 8, 2018: Infection and Immunity
https://www.readbyqxmd.com/read/29305981/the-effect-of-formulation-additives-on-in-vitro-dissolution-absorption-profile-and-in-vivo-bioavailability-of-telmisartan-from-brand-and-generic-formulations
#8
Enikő Borbás, Zsombor K Nagy, Brigitta Nagy, Attila Balogh, Balázs Farkas, Oksana Tsinman, Konstantin Tsinman, Bálint Sinkó
In this study, brand and four generic formulations of telmisartan, an antihypertensive drug, were used in in vitro simultaneous dissolution-absorption, investigating the effect of different formulation additives on dissolution and on absorption through an artificial membrane. The in vitro test was found to be sensitive enough to show even small differences between brand and generic formulations caused by the use of different excipients. By only changing the type of filler from sorbitol to mannitol in the formulation, the flux through the membrane was reduced by approximately 10%...
January 3, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29305142/oral-bioavailability-enhancement-of-%C3%AE-lapachone-a-poorly-soluble-fast-crystallizer-by-cocrystal-amorphous-solid-dispersion-and-crystalline-solid-dispersion
#9
Chengyu Liu, Zhengsheng Liu, Yuejie Chen, Zhen Chen, Huijun Chen, Yipshu Pui Feng Qian
The aim of this paper was to compare the in vitro dissolution and in vivo bioavailability of three solubility enhancement technologies for β-lapachone (LPC), a poorly water soluble compound with extremely high crystallization propensity. LPC cocrystal was prepared by co-grinding LPC with resorcinol. LPC crystalline and amorphous solid dispersions (CSD and ASD) were obtained by spray drying with Poloxamer 188 and HPMC-AS, respectively. The cocrystal structure was solved by single crystal x-ray diffraction. All formulations were characterized by WAXRD, DSC, POM and SEM...
January 2, 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29290535/novel-ultrasound-assisted-suture-anchor-system-using-the-bonewelding%C3%A2-technology-yields-a-comparable-primary-stability-in-osteopenic-and-healthy-human-humeri-as-a-benchmark-anchor
#10
Mehmet F Güleçyüz, Christian Schröder, Matthias F Pietschmann, Stephanie Göbel, Mario Lehmann, Jörg Mayer, Andreas Ficklscherer, Volkmar Jansson, Peter E Müller
INTRODUCTION: The aim of this biomechanical study was to evaluate the primary stability of the SportWelding® Sombrero 3.6 mm suture anchor system in osteopenic and healthy cadaveric humeri. METHODS: The Sombrero® and BioCorkscrew® anchors were deployed in 8 osteopenic and 4 healthy cadaver humeri after the bone mineral density (BMD) measurements of the 32 specimens. Both anchors were loaded with a USP Nr. 2 FiberWire® suture. An established cyclic testing protocol was performed...
December 28, 2017: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/29289674/investigating-the-impact-of-drug-crystallinity-in-amorphous-tacrolimus-capsules-on-pharmacokinetics-and-bioequivalence-using-discriminatory-in-vitro-dissolution-testing-and-pbpk-modeling-and-simulation
#11
Hitesh S Purohit, Niraj S Trasi, Dajun D Sun, Edwin C Y Chow, Hong Wen, Xinyuan Zhang, Yi Gao, Lynne S Taylor
Delivering a drug in amorphous form in a formulated product is a strategy used to enhance the apparent solubility of a drug substance and its oral bioavailability. Drug crystallization in such products may occur during the manufacturing process or upon storage, reducing the solubility advantage of the amorphous drug. However, the impact of partial drug crystallization in the drug product on the resulting bioavailability and pharmacokinetics is unknown. In this study, dissolution testing of commercial tacrolimus capsules (which are formulated to contain amorphous drug), both fresh and those containing different amounts of crystalline drug, was conducted using both USP and non-compendial dissolution tests with different dissolution media and volumes...
December 28, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29289332/are-multisource-levothyroxine-sodium-tablets-marketed-in-egypt-interchangeable
#12
Basant A Abou-Taleb, Maha Bondok, Mohamed Ismail Nounou, Nawal Khalafallah, Saleh Khalil
A clinical study was initiated in response to patients' complaints, supported by the treating physicians, of suspected differences in efficacy among multisource levothyroxine sodium tablets marketed in Egypt. The study design was a multiple dose (100μg levothyroxine sodium tablet once daily for 6 months) and involved 50 primary hypothyroidism female patients (5 equal groups). Tablets administered included five tablet batches (two brands, three origin locations) purchased from local pharmacies in Alexandria...
December 27, 2017: Annales D'endocrinologie
https://www.readbyqxmd.com/read/29287264/qualitative-assessment-of-extractables-from-single-use-components-and-the-impact-of-reference-standard-selection
#13
Mark Anderson Jordi, Smriti Khera, Kevin Roland, Liuwei Jiang, Paige Solomon, Jenny Nelson, Syed Salman Lateef, James Woods, Leland Martin, Samantha Martin, Frankie Aiello, Nina Chen
The advent of single-use bioprocess systems used for the delivery, storage or manufacture of biopharmaceuticals has introduced a new potential source for extractables and leachables (E&L) as these systems are comprised of polymeric materials. Several industry working groups, the FDA and USP have issued guidance and draft guidance on E&L analyses for a variety of applications. These documents typically indicate that mass spectrometry should be applied for discovery of E&L's but provide little guidance as to the exact analytical methodology which should be used...
December 19, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29276257/production-standard-and-stability-of-compounded-del-nido-cardioplegia-solution
#14
Luis M Pereira, Gregory S Matte, Peter Lutz, Alana Arnold, Al Patterson
Background: The del Nido cardioplegia solution (dNCS) was originally developed for pediatric cardiac surgery, being now also used for adult patients. Hospital pharmacies frequently resort to internal dNCS production which has led to an increase in the need for validated parameters for compounding and storage. Objective: This report defines in-house production standards, as well as the stability of dNCS under optimal storage conditions. Methods: All ingredients were sterile and United States Pharmacopeia (USP)/National Formulary (NF) certified...
December 2017: Hospital Pharmacy
https://www.readbyqxmd.com/read/29273610/stability-of-extemporaneously-prepared-preservative-free-prochlorperazine-nasal-spray
#15
Venkata K Yellepeddi
PURPOSE: The stability of an extemporaneously prepared preservative-free prochlorperazine 5-mg/mL nasal spray was evaluated. METHODS: The preservative-free prochlorperazine nasal spray was prepared by adding 250 mg of prochlorperazine edisylate to 50 mL of citrate buffer in a low-density polyethylene nasal spray bottle. A stability-indicating high-performance liquid chromatography (HPLC) method was developed and validated using the major degradant prochlorperazine sulfoxide and by performing forced-degradation studies...
January 1, 2018: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29273129/usp-s-revisions-to-sterile-compounding-standards-and-fda-guidance-impacts-on-mixing-of-allergen-extracts
#16
J Allen Meadows, Stephen Imbeau, Bill Finerfrock, Rebecca Burke, James L Sublett
No abstract text is available yet for this article.
January 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29247960/application-of-miniaturized-near-infrared-spectroscopy-for-quality-control-of-extemporaneous-orodispersible-films
#17
Wen Chin Foo, Effendi Widjaja, Yuet Mei Khong, Rajeev Gokhale, Sui Yung Chan
Extemporaneous oral preparations are routinely compounded in the pharmacy due to a lack of suitable formulations for special populations. Such small-scale pharmacy preparations also present an avenue for individualized pharmacotherapy. Orodispersible films (ODF) have increasingly been evaluated as a suitable dosage form for extemporaneous oral preparations. Nevertheless, as with all other extemporaneous preparations, safety and quality remain a concern. Although the United States Pharmacopeia (USP) recommends analytical testing of compounded preparations for quality assurance, pharmaceutical assays are typically not routinely performed for such non-sterile pharmacy preparations, due to the complexity and high cost of conventional assay methods such as high performance liquid chromatography (HPLC)...
December 13, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29242391/method-verification-requirements-for-an-advanced-imaging-system-for-microbial-plate-count-enumeration
#18
David Jones, Tony Cundell
Technical Abstract: The Growth Direct™ System that automates the incubation and reading of membrane filtration microbial counts on soybean-casein digest, Sabouraud dextrose and R2A agar differs only from the traditional method in that micro-colonies on the membrane are counted using an advanced imaging system up to 50% earlier in the incubation. Based on the recommendations in USP <1223> Validation of New Microbiological Testing Methods, the system may be implemented in a microbiology laboratory after simple method verification and not a full method validation...
December 14, 2017: PDA Journal of Pharmaceutical Science and Technology
https://www.readbyqxmd.com/read/29222363/stability-of-a-pyrimethamine-suspension-compounded-from-bulk-powder
#19
Paul O Lewis, David B Cluck, Jessica D Huffman, Amanda P Ogle, Stacy D Brown
PURPOSE: Development of a stability-indicating high-performance liquid chromatography (HPLC) method for pyrimethamine analysis, with subsequent application of that method to assess the 90-day stability of a pyrimethamine suspension compounded from bulk USP-grade pyrimethamine powder, is described. METHODS: A stability-indicating method of HPLC with ultraviolet detection specific to pyrimethamine was developed according to pharmacopeial recommendations and validated...
December 15, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29216262/direct-detection-of-mycobacterium-tuberculosis-rifampin-resistance-in-bio-safe-stained-sputum-smears
#20
Surabhi Lavania, Divya Anthwal, Manpreet Bhalla, Nagendra Singh, Sagarika Haldar, Jaya Sivaswami Tyagi
Direct smear microscopy of sputum forms the mainstay of TB diagnosis in resource-limited settings. Stained sputum smear slides can serve as a ready-made resource to transport sputum for molecular drug susceptibility testing. However, bio-safety is a major concern during transport of sputum/stained slides and for laboratory workers engaged in processing Mycobacterium tuberculosis infected sputum specimens. In this study, a bio-safe USP (Universal Sample Processing) concentration-based sputum processing method (Bio-safe method) was assessed on 87 M...
2017: PloS One
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