keyword
https://read.qxmd.com/read/38512249/vibration-controlled-transient-elastography-scores-to-predict-liver-related-events-in-steatotic-liver-disease
#21
JOURNAL ARTICLE
Huapeng Lin, Hye Won Lee, Terry Cheuk-Fung Yip, Emmanuel Tsochatzis, Salvatore Petta, Elisabetta Bugianesi, Masato Yoneda, Ming-Hua Zheng, Hannes Hagström, Jérôme Boursier, José Luis Calleja, George Boon-Bee Goh, Wah-Kheong Chan, Rocio Gallego-Durán, Arun J Sanyal, Victor de Lédinghen, Philip N Newsome, Jian-Gao Fan, Laurent Castéra, Michelle Lai, Stephen A Harrison, Céline Fournier-Poizat, Grace Lai-Hung Wong, Grazia Pennisi, Angelo Armandi, Atsushi Nakajima, Wen-Yue Liu, Ying Shang, Marc de Saint-Loup, Elba Llop, Kevin Kim-Jun Teh, Carmen Lara-Romero, Amon Asgharpour, Sara Mahgoub, Mandy Sau-Wai Chan, Clemence M Canivet, Manuel Romero-Gomez, Seung Up Kim, Vincent Wai-Sun Wong
IMPORTANCE: Metabolic dysfunction-associated steatotic liver disease (MASLD) is currently the most common chronic liver disease worldwide. It is important to develop noninvasive tests to assess the disease severity and prognosis. OBJECTIVE: To study the prognostic implications of baseline levels and dynamic changes of the vibration-controlled transient elastography (VCTE)-based scores developed for the diagnosis of advanced fibrosis (Agile 3+) and cirrhosis (Agile 4) in patients with MASLD...
March 21, 2024: JAMA
https://read.qxmd.com/read/38511983/effects-of-extracellular-calcium-concentration-on-hepatic-ischemia-reperfusion-injury-in-a-rat-model
#22
JOURNAL ARTICLE
Eun Ji Lee, Hyun Ji Hwang, Justin S Ko, MiHye Park
OBJECTIVES: Hypocalcemia is frequently identified during liver transplant. However, supplementation of extracellular calcium could induce increased intracellular calcium concentration, as a potential factor for injury to the liver graft. We evaluated the effects of regulating extracellular calcium concentrations on hepatic ischemia-reperfusion injury. MATERIALS AND METHODS: We randomly divided 24 Sprague-Dawley rats into 3 groups: group C received normal saline (n = 8), group L received citrate to induce hypocalcemia (n = 8), and group L-Co received citrate followed by calcium gluconate to ameliorate hypocalcemia (n = 8)...
February 2024: Experimental and Clinical Transplantation
https://read.qxmd.com/read/38509599/long-term-outcome-of-combined-radiologic-and-surgical-strategy-for-the-management-of-biliary-complications-after-pediatric-liver-transplantation
#23
JOURNAL ARTICLE
Ana M Calinescu, Sébastien Monluc, Stephanie Franchi-Abella, Dalila Habes, Gabrielle Weber, Marion F Almes, Jerome Waguet, Emmanuel Jacquemin, Virginie Fouquet, Jordi Miatello, Geraldine Hery, Catherine Baujard, Emmanuel Gonzales, Sophie Branchereau, Florent Guérin
OBJECTIVES: We aimed to analyze the risk factors for management failure of BC after pediatric liver transplantation (pLT) by retrospectively analyzing primary pLT performed between 1997 and 2018 (n = 620 patients). RESULTS: In all, 117/620 patients (19%) developed BC. The median (range) follow-up was 9 (1.4-21) years. Patient survival at 1, 5 and 10 years was 88.9%, 85.7%, 84.4% and liver graft survival was 82.4%, 77.4%, and 74.3% respectively...
March 20, 2024: BMC Research Notes
https://read.qxmd.com/read/38508920/exacerbated-ischemia-reperfusion-injury-in-fatty-livers-is-mediated-by-lipid-peroxidation-stress-and-ferroptosis
#24
JOURNAL ARTICLE
Zachary P Rokop, Wenjun Zhang, Nandini Ghosh, Nirupam Biswas, Amitava Das, Jingmei Lin, Chandan K Sen, Chandrashekhar Kubal
BACKGROUND: Ischemia-reperfusion injury is a common problem in liver surgery and transplantation. Although ischemia-reperfusion injury is known to be more pronounced in fatty livers, the underlying mechanisms for this difference remain poorly understood. We hypothesized that ferroptosis plays a significant role in fatty liver ischemia-reperfusion injury due to increased lipid peroxidation in the presence of stored iron in the fatty liver. To test this hypothesis, the ferroptosis pathway was evaluated in a murine fatty liver ischemia-reperfusion injury model...
March 19, 2024: Surgery
https://read.qxmd.com/read/38508162/transthoracic-transdiaphragmatic-approach-in-laparoscopic-liver-resection-for-hepatocellular-carcinoma-in-a-patient-with-severe-obesity-and-history-of-deceased-donor-liver-transplantation
#25
JOURNAL ARTICLE
Akira Umemura, Hiroyuki Nitta, Daiki Takeda, Hirokatsu Katagiri, Shoji Kanno, Akira Sasaki
BACKGROUND: The transthoracic transdiaphragmatic approach (TTA) for hepatic tumors in laparoscopic liver resection (LLR) is not usually employed because the caudal approach via the abdominal cavity is the gold standard in LLRs. Here, we present a case of LLR via TTA for hepatocellular carcinoma (HCC) in a patient with severe obesity and a history of deceased donor liver transplantation (DDLT). MATERIALS AND SURGICAL TECHNIQUE: The patient, a 64-year-old man with severe obesity and a history of DDLT, was referred to our hospital to undergo LLR for HCC located at the cranial side of segment IV...
April 2024: Asian Journal of Endoscopic Surgery
https://read.qxmd.com/read/38505744/assessment-of-hepatic-fibrosis-with-non-invasive-indices-in-subjects-with-diabetes-before-and-after-liver-transplantation
#26
JOURNAL ARTICLE
Valeria Grancini, Irene Cogliati, Gianfranco Alicandro, Alessia Gaglio, Stefano Gatti, Maria Francesca Donato, Emanuela Orsi, Veronica Resi
INTRODUCTION: One of the most common complications of cirrhosis is diabetes, which prevalence is strictly related to severity of hepatopathy. Actually, there are no data on the persistence of post-transplant glucose abnormalities and on a potential impact of diabetes on development of fibrosis in the transplanted liver. To this aim, we evaluated liver fibrosis in cirrhotic subjects before and after being transplanted. METHODS: The study included 111 individuals who had liver transplantation...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38505248/hepatitis-e-virus-hev-infection-among-immunocompromised-individuals-a-brief-narrative-review
#27
REVIEW
Radostina Alexandrova, Ilia Tsachev, Plamen Kirov, Abedulkadir Abudalleh, Hristo Hristov, Tanya Zhivkova, Lora Dyakova, Magdalena Baymakova
Hepatitis E virus (HEV) is a single-stranded positive-sense RNA virus that belongs to Hepeviridae family. HEV is the most common cause of acute viral hepatitis worldwide. According to the World Health Organization (WHO), there are estimated 20 million HEV infections worldwide every year, leading to estimated 3.3 million symptomatic cases of HEV infection. The WHO estimates that HEV infection caused approximately 44,000 deaths in 2015, which represents 3.3% of mortality rates due to viral hepatitis. In low-income (LI) countries and lower-middle-income (LMI) countries, HEV is a waterborne infection induced by HEV genotype (gt) 1 and HEV gt 2 that cause large outbreaks and affect young individuals with a high mortality rate in pregnant women from South Asian countries and patients with liver diseases...
2024: Infection and Drug Resistance
https://read.qxmd.com/read/38505059/hepatic-hydrothorax
#28
REVIEW
Hannah Wilkins, Ellie Britt, Malvika Bhatnagar, Benjamin Pippard
Hepatic hydrothorax (HH) refers to the presence of a pleural effusion that develops in the context of underlying liver cirrhosis and portal hypertension. It carries a high risk of morbidity and mortality, with a median survival of 8-12 months. Diagnosis is usually confirmed by pleural aspiration, demonstrating typical features of a transudative effusion in the absence of co-existent cardio-pulmonary or renal pathology. The clinical presentation is quite variable, with some patients remaining relatively asymptomatic in the presence of small or incidental effusions, while others present with frank respiratory failure requiring pleural intervention...
February 29, 2024: Journal of Thoracic Disease
https://read.qxmd.com/read/38503014/ischemia-and-reperfusion-injured-liver-derived-exosomes-elicit-acute-lung-injury-through-mir-122-5p-regulated-alveolar-macrophage-polarization
#29
JOURNAL ARTICLE
Jingshu Lyu, Mingwei Sheng, Yingli Cao, Lili Jia, Chen Zhang, Yiqi Weng, Wenli Yu
Acute lung injury (ALI) is a common postoperative complication, particularly in pediatric patients after liver transplantation. Hepatic ischemia-reperfusion (HIR) increases the release of exosomes (IR-Exos) in peripheral circulation. However, the role of IR-Exos in the pathogenesis of ALI induced by HIR remains unclear. Here, we explored the role of exosomes derived from the HIR-injured liver in ALI development. Intravenous injection of IR-Exos caused lung inflammation in naive rats, whereas pretreatment with an inhibitor of exosomal secretion (GW4869) attenuated HIR-related lung injury...
March 18, 2024: International Immunopharmacology
https://read.qxmd.com/read/38502810/mash-clinical-trials-and-drugs-pipeline-an-impending-tsunami
#30
JOURNAL ARTICLE
Mazen Noureddin
Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as NAFLD, has ascended to prominence as the predominant chronic liver disease in Western countries and now stands as a leading cause of liver transplantations. In the more advanced stage, Metabolic Dysfunction-Associated Steatohepatitis (MASH), may lead to fibrosis, a gateway to cirrhosis, liver cancer, and liver failure. Despite extensive research and exploration of various drug mechanisms, the anticipation for the inaugural approved drug to materialize by 2024 is palpable, marking a significant milestone...
March 19, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/38502002/onset-of-acute-severe-autoimmune-hepatitis-after-severe-acute-respiratory-syndrome-coronavirus-2-infection-a-case-report
#31
JOURNAL ARTICLE
Yi-Jun Zhou, Qiao-Fei Jin, Chen Wang, Xiao-Jing Zhang, Hong Liu, Jianfeng Bao
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can trigger autoimmune inflammation in the liver, leading to acute autoimmune hepatitis (AIH). We herein report a case involving a 39-year-old woman with a 23-day history of yellow skin and urine. Using the revised original scoring system of the International AIH Group, we definitively diagnosed the patient with acute severe AIH (AS-AIH). She began treatment with 80 mg/day intravenous methylprednisolone, which was gradually reduced and followed by eventual transition to oral methylprednisolone...
March 2024: Journal of International Medical Research
https://read.qxmd.com/read/38499735/development-of-clinical-algorithm-utilizing-vibration-controlled-transient-elastography-to-detect-advanced-hepatic-fibrosis-in-liver-transplant-recipients
#32
JOURNAL ARTICLE
Tamoore Arshad, Dylan Vainer, Hiba Khan, Alok Baral, Shreya Garg, Audrey Ang, Vaishali Patel, Vinay Kumaran, David Bruno, Seung Lee, Amit Sharma, Mark Muthiah, Anh T Bui, Mohammad Shadab Siddiqui
INTRODUCTION: Vibration-controlled transient elastography (VCTE) based liver stiffness measurement (LSM) is an excellent 'rule-out' test for advanced hepatic fibrosis in liver transplant (LT) recipients, however, its ability to 'rule-in' the disease is suboptimal. The study aimed to improve diagnostic performance of LSM in LT recipients. METHODS: Adult LT recipients with a liver biopsy and VCTE were included (N = 150). Sequential covering analysis was performed to create rules to identify patients at low or high risk for advanced fibrosis (stage 3-4)...
March 18, 2024: Digestive Diseases and Sciences
https://read.qxmd.com/read/38495918/graft-versus-leukaemia-immunity-is-retained-following-treatment-with-post-transplant-cyclophosphamide-alone-or-combined-with-tocilizumab-in-humanised-mice
#33
JOURNAL ARTICLE
Chloe Sligar, Ellie Reilly, Peter Cuthbertson, Kara L Vine, Katrina M Bird, Amal Elhage, Stephen I Alexander, Ronald Sluyter, Debbie Watson
OBJECTIVES: Donor haematopoietic stem cell transplantation treats leukaemia by inducing graft-versus-leukaemia (GVL) immunity. However, this benefit is often mitigated by graft-versus-host disease (GVHD), which is reduced by post-transplant cyclophosphamide (PTCy) alone or combined with tocilizumab (TOC) in humanised mice. This study established a preclinical humanised mouse model of GVL and investigated whether PTCy alone or combined with TOC impacts GVL immunity. METHODS: NOD- scid -IL2Rγnull mice were injected with 2 × 107 human peripheral blood mononuclear cells (hPBMCs) on day 0 and with 1 × 106 THP-1 acute myeloid leukaemia cells on day 14...
2024: Clinical & Translational Immunology
https://read.qxmd.com/read/38495452/treatment-journey-of-patients-with-hepatocellular-carcinoma-using-real-world-data-in-british-columbia-canada
#34
JOURNAL ARTICLE
Soo Jin Seung, Hasnain Saherawala, Brandon Zagorski, Carman Tong, Howard Lim, Peter Kim, Vladimir Marquez, Sharlene Gill, David Liu, Janine M Davies
AIM: This study examined treatment patterns, survival outcomes and healthcare costs related to hepatocellular carcinoma (HCC) in British Columbia. METHODS: The study utilized data from two physician databases (HCC and MOTION) and the provincial British Columbia transplant database. RESULTS: The analysis revealed diverse treatment approaches and identified the varying treatment journeys of patients. Liver transplant and systemic therapies demonstrated improved survival rates...
December 2023: Hepatic Oncology
https://read.qxmd.com/read/38495288/predicting-major-adverse-cardiovascular-events-after-orthotopic-liver-transplantation-using-a-supervised-machine-learning-model-a-cohort-study
#35
JOURNAL ARTICLE
Jonathan Soldera, Leandro Luis Corso, Matheus Machado Rech, Vinícius Remus Ballotin, Lucas Goldmann Bigarella, Fernanda Tomé, Nathalia Moraes, Rafael Sartori Balbinot, Santiago Rodriguez, Ajacio Bandeira de Mello Brandão, Bruno Hochhegger
BACKGROUND: Liver transplant (LT) patients have become older and sicker. The rate of post-LT major adverse cardiovascular events (MACE) has increased, and this in turn raises 30-d post-LT mortality. Noninvasive cardiac stress testing loses accuracy when applied to pre-LT cirrhotic patients. AIM: To assess the feasibility and accuracy of a machine learning model used to predict post-LT MACE in a regional cohort. METHODS: This retrospective cohort study involved 575 LT patients from a Southern Brazilian academic center...
February 27, 2024: World Journal of Hepatology
https://read.qxmd.com/read/38493695/bulk-and-single-cell-rna-sequencing-analysis-with-101-machine-learning-combinations-reveal-neutrophil-extracellular-trap-involvement-in-hepatic-ischemia-reperfusion-injury-and-early-allograft-dysfunction
#36
JOURNAL ARTICLE
Manling Xie, Zhen He, Bing Bin, Ning Wen, Jihua Wu, Xiaoyong Cai, Xuyong Sun
BACKGROUND: Hepatic ischaemia-reperfusion injury (HIRI) is a major clinical concern during the perioperative period and is closely associated with early allograft dysfunction (EAD), acute rejection (AR) and long-term graft survival. Neutrophil extracellular traps (NETs) are extracellular structures formed by the release of decondensed chromatin and granular proteins following neutrophil stimulation. There is growing evidence that NETs are involved in the progression of various liver transplantation complications, including ischaemia-reperfusion injury (IRI)...
March 16, 2024: International Immunopharmacology
https://read.qxmd.com/read/38492132/prophylaxis-of-hepatic-encephalopathy-current-and-future-drug-targets
#37
REVIEW
Sudhir Maharshi, Barjesh Chander Sharma
Hepatic encephalopathy is described by a broad spectrum of neurological and psychiatric aberrations resulting due to advanced liver dysfunction. It is a neurological disorder due to hepatic insufficiency and/or portosystemic shunts. Its clinical presentation includes neuropsychiatric dysfunction ranging from subclinical changes to comatose state. It is a sign of poor prognosis in cirrhotics with a high 1-year mortality. Each episode of hepatic encephalopathy leads to high hospitalization rate, poor prognosis and raised burden of healthcare...
March 16, 2024: Hepatology International
https://read.qxmd.com/read/38490364/modified-radiation-lobectomy-strategy-of-radioembolization-for-right-sided-unresectable-primary-liver-tumors
#38
JOURNAL ARTICLE
Qian Yu, Yating Wang, Ethan Ungchusri, Anjana Pillai, Chih-Yi Liao, John Fung, Diego DiSabato, Talia Baker, Mikin Patel, Thuong Van Ha, Osman Ahmed
PURPOSE: To assess the safety and effectiveness of using modified radiation lobectomy (mRL) to treat primary hepatic tumors located in the right hepatic lobe (segments V-VIII) and determine future liver remnant (FLR) hypertrophy. METHODS: A retrospective review was performed at a single institution to include 19 consecutive patients (7 Female, 12 Male) who underwent single-session mRL for right sided primary hepatic tumors: 15 received segmentectomy plus lobectomy (segmental dose >190 Gy and lobar dose >80 Gy); 4 were treated with the double-segmental approach (dominant segments >190 Gy and non-dominant segments > 80 Gy)...
March 13, 2024: Journal of Vascular and Interventional Radiology: JVIR
https://read.qxmd.com/read/38489699/gynura-segetum-induces-hepatic-sinusoidal-obstruction-syndrome-in-a-child-a-case-report
#39
JOURNAL ARTICLE
Qian Zheng, Haiyang Zhang
RATIONALE: Hepatic sinusoidal obstruction syndrome (HSOS), which includes hepatic stasis and portal hypertension, is a rare vascular disorder of the liver. It is often associated with hematopoietic stem cell transplantation. It is also possible to treat this disease using Chinese herbal medicines that contain pyrrolizidine alkaloids (PAs). This disease is extremely rare in children and poses a serious threat to their health. To our knowledge, this is the first case of HSOS in a child with PAs...
March 15, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38488837/gut-microbiota-derived-gamma-aminobutyric-acid-from-metformin-treatment-reduces-hepatic-ischemia-reperfusion-injury-through-inhibiting-ferroptosis
#40
JOURNAL ARTICLE
Fangyan Wang, Xiujie Liu, Furong Huang, Yan Zhou, Xinyu Wang, Zhengyang Song, Sisi Wang, Xiaoting Wang, Dibang Shi, Gaoyi Ruan, Xiawei Ji, Eryao Zhang, Zenglin Tan, Yuqing Ye, Chuang Wang, Jesse Zhu, Wantie Wang
Hepatic ischemia/reperfusion injury (HIRI) is a common and inevitable factor leading to poor prognosis in various liver diseases, making the outcomes of current treatments in clinic unsatisfactory. Metformin has been demonstrated to be beneficial to alleviate HIRI in recent studies, however, the underpinning mechanism remains unclear. In this study, we found metformin mitigates HIRI-induced ferroptosis through reshaped gut microbiota in mice, which was confirmed by the results of fecal microbiota transplantation treatment but showed the elimination of the beneficial effects when gut bacteria were depleted using antibiotics...
March 15, 2024: ELife
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