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https://www.readbyqxmd.com/read/29346398/dual-function-of-edta-with-silver-nanoparticles-for-root-canal-treatment-a-novel-modification
#1
Juan M Martinez-Andrade, Miguel Avalos-Borja, Alfredo R Vilchis-Nestor, Luis O Sanchez-Vargas, Ernestina Castro-Longoria
The chelating and antimicrobial capacity of a novel modification of 17% EDTA with silver nanoparticles (AgNPs) (EDTA-AgNPs) was evaluated in-vitro for root canal treatment (RCT). The EDTA-AgNPs solution was characterized by UV-Vis spectroscopy, ζ-potential and high-resolution transmission electron microscopy (HRTEM). Antimicrobial capacity was evaluated against Candida albicans and Staphylococcus aureus in planktonic and biofilm cells by broth macrodilution (24 h) and XTT assays, (1, 10 and 30 min) respectively...
2018: PloS One
https://www.readbyqxmd.com/read/29341887/molecular-basis-of-substrate-polyspecificity-of-the-candida-albicans-mdr1p-multidrug-h-antiporter
#2
Archana Kumari Redhu, Atanu Banerjee, Abdul Haseeb Shah, Alexis Moreno, Manpreet Kaur Rawal, Remya Nair, Pierre Falson, Rajendra Prasad
The molecular basis of polyspecificity of Mdr1p, a major drug/H+ antiporter of Candida albicans, is not elucidated. We have probed the nature of the drug-binding pocket by performing systematic mutagenesis of the 12 transmembrane segments. Replacement of the 252 amino acid residues with alanine or glycine yielded 2/3 neutral mutations while 1/3 led to the complete or selective lost of resistance to drugs or substrates transported by the pump. Using the GlpT-based 3D-model of Mdr1p, we roughly categorized these critical residues depending on their type and localization 1°/ main structural impact ("S" group), 2°/ exposure to the lipid interface ("L" group), 3°/ buried but not facing the main central pocket, inferred as critical for the overall H+/drug antiport mechanism ("M" group) and finally 4°/ buried and facing the main central pocket ("B" group)...
January 13, 2018: Journal of Molecular Biology
https://www.readbyqxmd.com/read/29340656/antagonistic-effect-of-saccharomyces-cerevisiae-ktp-and-issatchenkia-occidentalis-apc-on-hyphal-development-and-adhesion-of-candida-albicans
#3
K Lohith, K A Anu-Appaiah
The morphological transition from yeast to a hyphal form, as well as the adhesion capability to the gastrointestinal tract, are implicated virulent determinant in Candida albicans and could be potential targets for prevention of the opportunistic pathogen. Based on this rationale, two yeast strains Saccharomyces cerevisiae KTP and Issatchenkia occidentalis ApC along with reference strain Saccharomyces boulardii NCDC 363 were screened for the probiotic potential. Characters like pH, temperature, bile, simulated gastrointestinal juice tolerance tests, and Caco-2 cell line adhesion assay were determined in the present study...
January 11, 2018: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/29340060/assessment-of-antimicrobial-and-wound-healing-effects-of-brevinin-2ta-against-the-bacterium-klebsiella-pneumoniae-in-dermally-wounded-rats
#4
Siqin Liu, Qilin Long, Yang Xu, Jun Wang, Zhongwei Xu, Lei Wang, Mei Zhou, Yuxin Wu, Tianbao Chen, Chris Shaw
Antimicrobial peptides (AMPs) are regarded as promising alternatives for antibiotics due to their inherent capacity to prevent microbial drug resistance. Amphibians are rich source of bioactive molecules, which provide numerous AMPs with various structures as drug candidates. Here, we isolated and identified a novel AMP Brevinin-2Ta (B-2Ta) from the skin secretion of the European frog, Pelophylax kl. esculentus. In vitro studies revealed that it showed broad antimicrobial activities against S. aureus, E. coli and C...
December 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29339423/immune-protection-against-lethal-fungal-bacterial-intra-abdominal-infections
#5
Elizabeth A Lilly, Melanie Ikeh, Evelyn E Nash, Paul L Fidel, Mairi C Noverr
Polymicrobial intra-abdominal infections (IAIs) are clinically prevalent and cause significant morbidity and mortality, especially those involving fungi. Our laboratory developed a mouse model of IAI and demonstrated that intraperitoneal inoculation with Candida albicans or other virulent non-albicans Candida (NAC) species plus Staphylococcus aureus resulted in 70 to 80% mortality in 48 to 72 h due to robust local and systemic inflammation (sepsis). Surprisingly, inoculation with Candida dubliniensis or Candida glabrata with S...
January 16, 2018: MBio
https://www.readbyqxmd.com/read/29337983/wor1-establishes-opaque-cell-fate-through-inhibition-of-the-general-co-repressor-tup1-in-candida-albicans
#6
Selma S Alkafeef, Clinton Yu, Lan Huang, Haoping Liu
The pathogenic fungus Candida albicans can undergo phenotypic switching between two heritable states: white and opaque. This phenotypic plasticity facilitates its colonization in distinct host niches. The master regulator WOR1 is exclusively expressed in opaque phase cells. Positive feedback regulation by Wor1 on the WOR1 promoter is essential for opaque formation, however the underlying mechanism of how Wor1 functions is not clear. Here, we use tandem affinity purification coupled with mass spectrometry to identify Wor1-interacting proteins...
January 16, 2018: PLoS Genetics
https://www.readbyqxmd.com/read/29335835/etiology-of-invasive-candidosis-agents-in-russia-a-multicenter-epidemiological-survey
#7
N V Vasilyeva, E R Raush, M V Rudneva, T S Bogomolova, A E Taraskina, Yong Fang, Fengmin Zhang, N N Klimko
A multicenter prospective epidemiological survey on the etiologic agents of invasive candidosis was conducted in Russia in the period of 2012-2014. Samples were collected from 284 patients with invasive candidosis and Candida species isolated by culture. The species were identified by DNA sequencing and MALDI-TOF massspectrometry. A total of 322 isolates were recovered, in which 96% of Сandida species belonged to six major species, namely, C. albicans (43.2%), C. parapsilosis (20.2%), C. glabrata (11.5%), C...
January 16, 2018: Frontiers of Medicine
https://www.readbyqxmd.com/read/29331410/implementing-crispr-cas-technologies-in-conventional-and-non-conventional-yeasts-current-state-and-future-prospects
#8
REVIEW
Hana Raschmanova, Astrid Weninger, Anton Glieder, Karin Kovar, Thomas Vogl
Within five years, the CRISPR-Cas system has emerged as the dominating tool for genome engineering, while also changing the speed and efficiency of metabolic engineering in conventional (Saccharomyces cerevisiae and Schizosaccharomyces pombe) and non-conventional (Yarrowia lipolytica, Pichia pastoris syn. Komagataella phaffii, Kluyveromyces lactis, Candida albicans and C. glabrata) yeasts. Especially in S. cerevisiae, an extensive toolbox of advanced CRISPR-related applications has been established, including crisprTFs and gene drives...
January 10, 2018: Biotechnology Advances
https://www.readbyqxmd.com/read/29331369/equisetum-telmateia-extracts-chemical-compositions-antioxidant-activity-and-antimicrobial-effect-on-the-growth-of-some-pathogenic-strain-causing-poisoning-and-infection
#9
Marzie Yeganegi, Farideh Tabatabaei Yazdi, Seyed Ali Mortazavi, Javad Asili, Behrooz Alizadeh Behbahani, Adel Beig Babaei
The aerial parts of Equisetum telmateia have been used as a source of biologically active compounds to treat inflammatory, diarrhea, stomach-ache, eczema and mouth infections in traditional medicine. The aim of this work is to evaluate the extraction yield, chemical compositions, antioxidant activity and antimicrobial activity of E. telmateia extracts on Staphylococcus aureus, Bacillus cereus, Escherichia coli, Salmonella typhi and Candida albicans. Chemical compositions E. telmateia was analyzed by high performance liquid chromatography (HPLC) using a C18 column...
January 10, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29329277/synthesis-structural-characterization-antimicrobial-activity-and-in-vitro-biocompatibility-of-new-unsaturated-carboxylate-complexes-with-2-2-bipyridine
#10
Gina Vasile Scăețeanu, Mariana Carmen Chifiriuc, Coralia Bleotu, Crina Kamerzan, Luminiţa Măruţescu, Constantin G Daniliuc, Cătălin Maxim, Larisa Calu, Rodica Olar, Mihaela Badea
The synthesis, structural characterization, cytotoxicity, and antimicrobial properties of four new complexes formed by employing acrylate anion and 2,2'-bipyridine are reported herein. X-ray crystallography revealed the trinuclear nature of [Mn₃(2,2'-bipy)₂(C₃H₃O₂)₆] (1), meanwhile complexes with general formula [M(2,2'-bipy)(C₃H₃O₂)₂(H₂O)x]∙yH₂O ((2) M: Ni, x = 1, y = 0; (3) M: Cu, x = 1, y = 0; (4) M: Zn, x = 0, y = 1; 2,2'-bipy: 2,2'-bipyridine; C₃H₃O₂: acrylate anion) were shown to be mononuclear...
January 12, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29325916/proanthocyanidin-polymeric-tannins-from-stryphnodendron-adstringens-are-effective-against-fluconazole-resistant-candida-spp-and-treat-vaginal-candidiasis
#11
Aline Luiza Duarte de Freitas, Vanessa Kaplum, Diego Conrado Pereira Rossi, Leandro Buffoni Roque da Silva, Márcia de Souza Carvalho Melhem, Carlos Pelleschi Taborda, João Carlos Palazzo de Mello, Celso Vataru Nakamura, Kelly Ishida
ETHNOPHARMACOLOGICAL RELEVANCE: The stem bark of Stryphnodendron adstringens (Mart.) Coville is popularly used as anti-inflammatory, astringent and in the treatment of wounds and vaginal infections. Several pharmacological activities have been scientifically proven by "in vitro" and "in vivo" experimental assays for antibacterial, antiviral, antiprotozoan, anti-inflammatory and antioxidant. AIM OF THE STUDY: We investigated whether proanthocyanidin polymeric tannins from the Stryphnodendron adstringens steam bark with antifungal activity against Candida albicans in vitro are also active against planktonic and biofilm cells of Candida non-albicans (CNA, including fluconazole-resistant isolates) and are capable of controlling Candida vaginitis in vivo...
January 8, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29325167/a-multicentre-study-of-antifungal-susceptibility-patterns-among-350-candida-auris-isolates-2009-17-in-india-role-of-the-erg11-and-fks1-genes-in-azole-and-echinocandin-resistance
#12
Anuradha Chowdhary, Anupam Prakash, Cheshta Sharma, Milena Kordalewska, Anil Kumar, Smita Sarma, Bansidhar Tarai, Ashutosh Singh, Gargi Upadhyaya, Shalini Upadhyay, Priyanka Yadav, Pradeep K Singh, Vikas Khillan, Neelam Sachdeva, David S Perlin, Jacques F Meis
Background: Candida auris has emerged globally as an MDR nosocomial pathogen in ICU patients. Objectives: We studied the antifungal susceptibility of C. auris isolates (n = 350) from 10 hospitals in India collected over a period of 8 years. To investigate azole resistance, ERG11 gene sequencing and expression profiling was conducted. In addition, echinocandin resistance linked to mutations in the C. auris FKS1 gene was analysed. Methods: CLSI antifungal susceptibility testing of six azoles, amphotericin B, three echinocandins, terbinafine, 5-flucytosine and nystatin was conducted...
January 9, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29324230/neutrophils-cause-an-intravascular-traffic-jam
#13
Martin S Minns, Eric Pearlman
Neutrophil swarming is defined by large numbers of cells simultaneously and rapidly migrating to a site of injury or infection. In this issue of Cell Host & Microbe, Lee et al. (2018) demonstrate that intravascular swarming of neutrophils occurs in response to Candida albicans infection and causes vascular occlusion and pathological sequelae.
January 10, 2018: Cell Host & Microbe
https://www.readbyqxmd.com/read/29322829/chemical-composition-and-antimicrobial-activity-of-the-essential-oils-from-flowers-and-leaves-of-grindelia-integrifolia-dc
#14
Sławomira Nowak, Paweł Lisiecki, Anna Tomaszczak-Nowak, Ewa Grudzińska, Monika Anna Olszewska, Agnieszka Kicel
Essential oils from flowers and leaves of Grindelia integrifolia DC. were investigated for the first time in terms of chemical composition and antimicrobial activity. The GC-FID/MS analysis allowed for the identification of 58 and 72 volatiles, comprising 92.4 and 90.1% of the oils, respectively. The major components of the flower oil were α-pinene (34.9%) and limonene (13.1%), while myrcene (16.9%), spathulenol (12.3%), β-eudesmol (11.9%) and limonene (10.1%) dominated among the leaf volatiles. The antimicrobial activity, evaluated against 12 selected bacteria and fungus, was found moderate, with the strongest effect of both oils observed against C...
January 11, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29317147/fusarithioamide-b-a-new-benzamide-derivative-from-the-endophytic-fungus-fusarium-chlamydosporium-with-potent-cytotoxic-and-antimicrobial-activities
#15
Sabrin R M Ibrahim, Gamal A Mohamed, Rwaida A Al Haidari, Mohamed F Zayed, Amal A El-Kholy, Ehab S Elkhayat, Samir A Ross
Fusarithioamide B (6), a new aminobenzamide derivative with unprecedented carbon skeleton and five known metabolites: stigmast-4-ene-3-one (1), stigmasta-4,6,8(14),22-tetraen-3-one (2), p-hydroxyacetophenone (3), tyrosol (4), and fusarithioamide A (5) were separated from Fusarium chlamydosporium EtOAc extract isolated from Anvillea garcinii (Burm.f.) DC. leaves (Asteraceae). The structure elucidation and completeassignment of the isolated metabolites were performed mainly by the aid of various NMR and MS data...
December 30, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/29314280/fabrication-of-silver-chloride-nanoparticles-using-a-plant-serine-protease-in-combination-with-photo-activation-and-investigation-of-their-biological-activities
#16
Jaruwan Siritapetawee, Wanwisa Limphirat, Nawarat Nantapong, Dujdow Songthamwat
Recently, the development of 'green' methods for fabrication of silver nanoparticles (Ag-NPs) has been emphasized, in view of their environmental safety, feasibility and low cost. In this study, a serine protease, EuP-82 from Euphorbia cf. lactea latex, was used to fabricate silver chloride nanoparticles (AgCl-NPs) in phosphate-buffered saline (pH 7.2), under the influence of visible light. The fabricated nanoparticles had a maximal surface plasmon resonance absorption peak at 435 nm. The size of the AgCl-NPs, estimated by scanning electron microscopy, was 57 ± 14...
January 3, 2018: Biotechnology and Applied Biochemistry
https://www.readbyqxmd.com/read/29305718/synthesis-characterization-and-evaluation-of-antimicrobial-and-cytotoxic-activities-of-biogenic-silver-nanoparticles-synthesized-from-streptomyces-xinghaiensis-of1-strain
#17
Magdalena Wypij, Joanna Czarnecka, Magdalena Świecimska, Hanna Dahm, Mahendra Rai, Patrycja Golinska
We report synthesis of silver nanoparticles (AgNPs) from Streptomyces xinghaiensis OF1 strain, which were characterised by UV-Vis and Fourier transform infrared spectroscopy, Zeta sizer, Nano tracking analyser, and Transmission electron microscopy. The antimicrobial activity of AgNPs alone, and in combination with antibiotics was evaluated against bacteria, namely Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Bacillus subtilis, and yeasts viz., Candida albicans and Malassezia furfur by using micro-dilution method...
January 5, 2018: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/29305296/one-step-synthesis-of-carbohydrate-esters-as-antibacterial-and-antifungal-agents
#18
Madher N AlFindee, Qian Zhang, Yagya Prasad Subedi, Jaya P Shrestha, Yukie Kawasaki, Michelle Grilley, Jon Y Takemoto, Cheng-Wei Tom Chang
Carbohydrate esters are biodegradable, and the degraded adducts are naturally occurring carbohydrates and fatty acids which are environmentally friendly and non-toxic to human. A simple one-step regioselective acylation of mono-carbohydrates has been developed that leads to the synthesis of a wide range of carbohydrate esters. Screening of these acylated carbohydrates revealed that several compounds were active against a panel of bacteria and fungi, including Staphylococcus aureus, methicillin-resistant S. aureus (MRSA), Candida albicans, Cryptococcus neoformans, Aspergillus flavus and Fusarium graminearum...
December 26, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/29303754/surface-treatment-of-implant-materials-with-antimicrobial-nanoparticulates
#19
Nathalia Ferraz Oliscovicz, Denise Tornavoi de Castro, Mariana Lima da Costa Valente, Evandro Watanabe, César Penazzo Lepri, Andréa Cândido Dos Reis
This study analyzed nanostructured silver vanadate (AgVO3) films on certain substrate surfaces found in dental implant devices in order to see if these films promote antimicrobial activity. Enamel and glaze vehicles were used to apply the nanomaterial (0.0% [control], 2.5%, 5.0%, and 10.0% concentrations) on 3 substrates (280 specimens per substrate): polytetrafluoroethylene (PTFE), polyacetal, and acrylic resin. An agar diffusion method was performed in triplicate to determine the antimicrobial activity against 8 microorganisms...
January 2018: General Dentistry
https://www.readbyqxmd.com/read/29302625/quantitation-of-ergosterol-content-and-gene-expression-profile-of-erg11-gene-in-fluconazole-resistant-candida-albicans
#20
F Alizadeh, A Khodavandi, S Zalakian
Background and Purpose: The frequency of opportunistic fungal infections in immunocompromised patients, especially by Candida species, has sharply increased in the last few decades. The objective of this study was to analyse the ergosterol content and gene expression profiling of clinical isolates of fluconazole-resistant Candida albicans. Materials and Methods: Sixty clinical samples were identified and collected from immunocompromised patients, namely recurrent oral, vaginal, and cutaneous candidiasis, during 2015-16...
March 2017: Advances in Medical Mycology (Iran)
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