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EDITORIAL
Donald L Opitz
This editorial introduces the collection, "Specialists with Spirit: Re-Enchanting the Vocation of Science," co-edited by Dorien Daling and Hanneke Hoekstra. The collection offers a tribute to the eminent historian of science, Klaas van Berkel, commemorating his retirement from the University of Groningen. The papers compel us to consider the ongoing tensions between knowledge production and the social, political, and economic constraints faced by scholars, a theme that Max Weber famously addressed in his 1917 lecture, Wissenschaft als Beruf, which the collection's contributors revisit as they consider a range of historical and contemporary questions concerning science and its study by historians...
March 18, 2024: Endeavour
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JOURNAL ARTICLE
Jin Shang, Liangliang Duan, Weimin Zhang, Qibin Zhuang, Xiaomei Ren, Dale Gu
Bletilla striata polysaccharide (BSP) was added to curdlan to form a blend hydrogel through a simple heating-cooling procedure to improve the hydrophilicity and healing efficacy of curdlan-based hydrogel used in wound healing. We explored the interplay between BSP and curdlan, studied how BSP concentration affects the physical properties and microstructures of hydrogels, and examined the biocompatibility and healing properties of the blend hydrogel. It was proved that the hydrogel framework was primarily formed by ordered arranged curdlan molecules, with BSP uniformly dispersed and intertwined with curdlan through hydrogen bonding...
March 11, 2024: Journal of Biomaterials Applications
#3
JOURNAL ARTICLE
Krista L Ward, Dale F Johnson, Barbara L Delli Gatti, Monica Smith
OBJECTIVE: The doctor of chiropractic program (DCP) graduate must demonstrate competency in clinical research literacy (CRL), per accreditation standards. This study aimed to compare student CRL knowledge, confidence, and attitudes between the beginning and end of their DCP. METHODS: We collected data on 245 matriculating students' CRL knowledge, confidence, and attitudes between 2017 and 2018. In 2021 and 2022, 78 of these students enrolled in a course with an extra credit assignment that was used to re-collect CRL data as they approached graduation...
February 7, 2024: Journal of Chiropractic Education
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JOURNAL ARTICLE
Jennifer Keating, Mirko Uljarević, Stephanie H M van Goozen, Kirsten Abbot-Smith, Dale F Hay, Susan R Leekam
In this paper, we investigated the psychometric properties of the Child Communication Checklist-Revised (CCC-R) for the first time with an English-speaking sample. We used a confirmatory application of exploratory structural equation modeling (ESEM) to re-evaluate the CCC-R's psychometric properties. We found strong support for its use as an assessment for pragmatic and structural language. Our second main aim was to explore associations between pragmatic and structural language and restricted and repetitive behaviors (RRBs), two hallmark characteristics of autism...
February 4, 2024: Autism Research: Official Journal of the International Society for Autism Research
#5
JOURNAL ARTICLE
Jeremy Dale, Veronica Nanton, Theresa Day, Patricia Apenteng, Celia Janine Bernstein, Gillian Grason Smith, Peter Strong, Rob Procter
BACKGROUND: Informal carers play a major role in supporting relatives and friends who are sick, disabled, or frail. Access to information, guidance, and support that are relevant to the lives and circumstances of carers is critical to carers feeling supported in their role. When unmet, this need is known to adversely affect carer resilience and well-being. To address this problem, Care Companion was co-designed with current and former carers and stakeholders as a free-to-use, web-based resource to provide access to a broad range of tailored information, including links to local and national resources...
September 21, 2023: JMIR aging
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JOURNAL ARTICLE
Verity Ahern, Sebastian Adeberg, Piero Fossati, Richard Garrett, Bradford Hoppe, Anita Mahajan, Ester Orlandi, Roberto Orecchia, Dale Prokopovich, Jan Seuntjens, David Thwaites, Daniel Trifiletti, Richard Tsang, Hiroshi Tsuji
BACKGROUND AND PURPOSE: To establish the treatment indications and potential patient numbers for carbon ion radiation therapy (CIRT) at the proposed national carbon ion (and proton) therapy facility in the Westmead precinct, New South Wales (NSW), Australia. METHODS: An expert panel was convened, including representatives of four operational and two proposed international carbon ion facilities, as well as NSW-based CIRT stakeholders. They met virtually to consider CIRT available evidence and experience...
July 20, 2023: Radiotherapy and Oncology
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JOURNAL ARTICLE
B R Baltaretu, W Dale Stevens, E Freud, J D Crawford
Saccades change eye position and interrupt vision several times per second, necessitating neural mechanisms for continuous perception of object identity, orientation, and location. Neuroimaging studies suggest that occipital and parietal cortex play complementary roles for transsaccadic perception of intrinsic versus extrinsic spatial properties, e.g., dorsomedial occipital cortex (cuneus) is sensitive to changes in spatial frequency, whereas the supramarginal gyrus (SMG) is modulated by changes in object orientation...
July 19, 2023: Scientific Reports
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JOURNAL ARTICLE
Cecilie Delphin Amdal, Jon Magne Moan, Einar Dale, Ragnhild Sørum Falk, Safora Johansen, Kristin Bjordal
PURPOSE: Describe the clinical outcome of hyperfractionated re-irradiation (HFRT) in patients with recurrent or second primary (SP) head and neck cancer (HNC). METHODS: This prospective observational study included HNC patients eligible for HFRT. Inclusion criteria: age ≥18 years, recurrent or SP HNC, planned re-irradiation and ability to respond to questionnaires. Patients received 1.5 Gy twice daily, five days a week for three (palliative) or four (curative/local control) weeks, total dose 45/60 Gy...
September 2023: Clinical and Translational Radiation Oncology
#9
JOURNAL ARTICLE
Fatma Pertek Hatipoglu, Güldane Magat, Ömer Hatipoğlu, Hanan Al-Khatib, Anas S Elatrash, Imran Zainal Abidin, Tomasz Kulczyk, Moataz-Bellah Ahmed Mohamed Alkhawas, Glynn Dale Buchanan, Kopbayeva Maira, Sugumaran Surendar, Muhammad Qasim Javed, Ahmed A Madfa, Sebastian Bürklein, Sarah Kolak, Usman Anwer Bhatti, Tulegenova Indira Maratovna, Paulo J Palma, João Filipe Brochado Martins
AIM: The aim of this study was two-folded: i) to assess the prevalence of Distolingual Canal (DLC) and Radix Entomolaris (RE) in Mandibular First Molars (M1Ms), using CBCT images, and ii) to assess the impact of sociodemographic factors on the prevalence of these conditions worldwide. METHODS: Cone Beam Computed Tomography (CBCT) images were scanned retrospectively and the ones including bilateral M1Ms were included in the study. The evaluation was performed by one researcher in each country, trained with CBCT technology...
June 30, 2023: Journal of Endodontics
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REVIEW
Firyal Ramzan, Fatima Abrar, Gyana Gourab Mishra, Lucia Meng Qi Liao, Dale D O Martin
One of the first molecular events in neurodegenerative diseases, regardless of etiology, is protein mislocalization. Protein mislocalization in neurons is often linked to proteostasis deficiencies leading to the build-up of misfolded proteins and/or organelles that contributes to cellular toxicity and cell death. By understanding how proteins mislocalize in neurons, we can develop novel therapeutics that target the earliest stages of neurodegeneration. A critical mechanism regulating protein localization and proteostasis in neurons is the protein-lipid modification S-acylation, the reversible addition of fatty acids to cysteine residues...
2023: Frontiers in Physiology
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JOURNAL ARTICLE
Alexander Drilon, Manish R Sharma, Melissa L Johnson, Timothy A Yap, Shirish Gadgeel, Dale Nepert, Gang Feng, Micaela B Reddy, Allison S Harney, Mohamed Elsayed, Adam W Cook, Christina E Wong, Ronald J Hinklin, Yutong Jiang, Eric N Brown, Nickolas A Neitzel, Ellen R Laird, Wen-I Wu, Anurag Singh, Ping Wei, Keith A Ching, John J Gaudino, Patrice A Lee, Dylan P Hartley, S Michael Rothenberg
UNLABELLED: Rationally targeted therapies have transformed cancer treatment, but many patients develop resistance through bypass signaling pathway activation. PF-07284892 (ARRY-558) is an allosteric SHP2 inhibitor designed to overcome bypass-signaling-mediated resistance when combined with inhibitors of various oncogenic drivers. Activity in this setting was confirmed in diverse tumor models. Patients with ALK fusion-positive lung cancer, BRAFV600E-mutant colorectal cancer, KRASG12D-mutant ovarian cancer, and ROS1 fusion-positive pancreatic cancer who previously developed targeted therapy resistance were treated with PF-07284892 on the first dose level of a first-in-human clinical trial...
June 3, 2023: Cancer Discovery
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JOURNAL ARTICLE
Elizabeth T Loggers, Amy A Case, Marcin Chwistek, William Dale, Marvin O Delgado Guay, Stephen B Edge, Steven R Grossman, Jillian Gustin, Judith Nelson, Sahana Rajasekhara, Akhila Reddy, James A Tulsky, Finly Zachariah, Kristen McNiff Landrum
BACKGROUND: High-quality, timely goals of care communication (GOCC) may improve patient and caregiver outcomes and promote care that is consistent with patient preferences. PROBLEM: Cancer patients, and their loved ones, appreciate GOCC; however, oncologists often lack formal communication training, institutional support and structures necessary to promote the delivery, documentation, and longitudinal follow-up of GOCC. PROPOSED SOLUTION: The Alliance of Dedicated Cancer Centers (ADCC), representing 10 U...
August 2023: Journal of Pain and Symptom Management
#13
JOURNAL ARTICLE
Mai Utada, Alina V Brenner, Dale L Preston, Michiko Yamada, Eric J Grant, Hiromi Sugiyama, Ritsu Sakata, Elizabeth K Cahoon, Kotaro Ozasa, Kiyohiko Mabuchi
Following our previous report on the radiation dose-response for prostate cancer incidence rates in the Life Span Study (LSS) cohort of atomic bomb survivors, we re-evaluated the radiation-related risk adjusting for differences in baseline cancer incidence rates among three subsets of the LSS cohort defined by the timing of their first participation in biennial health examinations offered to the Adult Health Study (AHS) sub-cohort members and prostate-specific-antigen (PSA) testing status for AHS participants: 1...
April 28, 2023: Radiation Research
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JOURNAL ARTICLE
Depleting CD103+ resident memory T cells in vivo reveals immunostimulatory functions in oral mucosa.
J Michael Stolley, Milcah C Scott, Vineet Joag, Alexander J Dale, Timothy S Johnston, Flavia Saavedra, Noah V Gavil, Sahar Lotfi-Emran, Andrew G Soerens, Eyob Weyu, Mark J Pierson, Mark C Herzberg, Nu Zhang, Vaiva Vezys, David Masopust
The oral mucosa is a frontline for microbial exposure and juxtaposes several unique tissues and mechanical structures. Based on parabiotic surgery of mice receiving systemic viral infections or co-housing with microbially diverse pet shop mice, we report that the oral mucosa harbors CD8+ CD103+ resident memory T cells (TRM), which locally survey tissues without recirculating. Oral antigen re-encounter during the effector phase of immune responses potentiated TRM establishment within tongue, gums, palate, and cheek...
July 3, 2023: Journal of Experimental Medicine
#15
REVIEW
Tianhao Zhang, Daling Deng, Shiqian Huang, Daan Fu, Tingting Wang, Feng Xu, Lulin Ma, Yuanyuan Ding, Kaixin Wang, Yafeng Wang, Wenjing Zhao, Xiangdong Chen
Studies on the neuroprotective effects of anesthetics were carried out more than half a century ago. Subsequently, many cell and animal experiments attempted to verify the findings. However, in clinical trials, the neuroprotective effects of anesthetics were not observed. These contradictory results suggest a mismatch between basic research and clinical trials. The Stroke Therapy Academic Industry Roundtable X (STAIR) proposed that the emergence of endovascular thrombectomy (EVT) would provide a proper platform to verify the neuroprotective effects of anesthetics because the haemodynamics of patients undergoing EVT is very close to the ischaemia-reperfusion model in basic research...
2023: Frontiers in Neuroscience
#16
JOURNAL ARTICLE
Yajing Xu, Dale Moulding, Wenanlan Jin, Simon Beggs
Peripheral injury during the early postnatal period alters the somatosensory system, leading to behavioural hyperalgesia upon re-injury in adulthood. Spinal microglia have been implicated as the cellular mediators of this phenomenon, but the mechanism is unclear. We hypothesised that neonatal injury (1) alters microglial phagocytosis of synapses in the dorsal horn leading to long-term structural changes in neurons, and/or (2) trains microglia, leading to a stronger microglial response after re-injury in adulthood...
April 8, 2023: Brain, Behavior, and Immunity
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JOURNAL ARTICLE
William S Tierney, Li-Ching Huang, Sheau-Chiann Chen, Lynn D Berry, Catherine Anderson, Milan R Amin, Michael S Benninger, Joel H Blumin, Jonathan M Bock, Paul C Bryson, Paul F Castellanos, Matthew S Clary, Seth M Cohen, Brianna K Crawley, Seth H Dailey, James J Daniero, Alessandro de Alarcon, Donald T Donovan, Eric S Edell, Dale C Ekbom, Daniel S Fink, Ramon A Franco, Catherine Gaelyn Garrett, Elizabeth A Guardiani, Alexander T Hillel, Henry T Hoffman, Norman D Hogikyan, Rebecca J Howell, Michael M Johns, Jan L Kasperbauer, Sid M Khosla, Cheryl Kinnard, Robbi A Kupfer, Alexander J Langerman, Robert J Lentz, Robert R Lorenz, David G Lott, Samir S Makani, Fabien Maldonado, Laura Matrka, Andrew J McWhorter, Albert L Merati, Matthew Mori, James L Netterville, Karla O'Dell, Julina Ongkasuwan, Gregory N Postma, Lindsay S Reder, Sarah L Rohde, Brent E Richardson, Otis B Rickman, Clark A Rosen, Matthew Rohlfing, Michael J Rutter, Guri S Sandhu, Joshua S Schindler, Glenn Todd Schneider, Rupali N Shah, Andrew G Sikora, Robert J Sinard, Marshall E Smith, Libby J Smith, Ahmed M S Soliman, Sigríður Sveinsdóttir, David Veivers, Sunil P Verma, Paul M Weinberger, Philip A Weissbrod, Christopher T Wootten, Yu Shyr, David O Francis, Alexander Gelbard
The North American Airway Collaborative (NoAAC) previously published a 3-year multi-institutional prospective cohort study showing variation in treatment effectiveness between 3 primary surgical techniques for idiopathic subglottic stenosis (iSGS). In this report, we update these findings to include 5 years of data evaluating treatment effectiveness. Patients in the NoAAC cohort were re-enrolled for 2 additional years and followed using the prespecified published protocol. Consistent with prior data, prospective observation of 487 iSGS patients for 5 years showed treatment effectiveness differed by modality...
June 2023: Otolaryngology—Head and Neck Surgery
#18
JOURNAL ARTICLE
Katherine E Trevers, Hui-Chun Lu, Youwen Yang, Alexandre P Thiery, Anna C Strobl, Claire Anderson, Božena Pálinkášová, Nidia M M de Oliveira, Irene M de Almeida, Mohsin A F Khan, Natalia Moncaut, Nicholas M Luscombe, Leslie Dale, Andrea Streit, Claudio D Stern
During early vertebrate development, signals from a special region of the embryo, the organizer, can re-direct the fate of non-neural ectoderm cells to form a complete, patterned nervous system. This is called neural induction and has generally been imagined as a single signalling event, causing a switch of fate. Here we undertake a comprehensive analysis, in very fine time-course, of the events following exposure of competent ectoderm of the chick to the organizer (the tip of the primitive streak, Hensen's node)...
March 3, 2023: ELife
#19
JOURNAL ARTICLE
Dale Jobson, Benjamin Roffey, Renee Best, Alison Button-Sloan, Danica Cossio, Sue Evans, Catherine Shang, Julie Moore, Christopher Arnold, Graham Mann, Mark Shackleton, H Peter Soyer, Rachel L Morton, John Zalcberg, Victoria Mar
INTRODUCTION: Australia has the highest incidence of melanoma in the world with variable care provided by a diverse range of clinicians. Clinical quality registries aim to identify these variations in care and provide anonymised, benchmarked feedback to clinicians and institutions to improve patient outcomes. The Australian Melanoma Clinical Outcomes Registry (MelCOR) aims to collect population-wide, clinical-level data for the early management of cutaneous melanoma and provide anonymised feedback to healthcare providers...
September 2, 2022: BMJ Open
#20
JOURNAL ARTICLE
Raed Sulaiman, Pradip De, Jennifer C Aske, Xiaoqian Lin, Adam Dale, Nischal Koirala, Kris Gaster, Luis Rojas Espaillat, David Starks, Nandini Dey
Ovarian cancers rank first in both aggressiveness and dismal prognosis among gynecological neoplasms. The poor outcome is explained by the fact that most patients present with late-stage disease and progress through the first line of treatment. Ovarian neoplasms, especially epithelial ovarian cancers, are diagnosed at advanced/metastatic stages, often with a high angiogenesis index, one of the hallmarks of ovarian cancers with rapid progression and poor outcome as resistance to anti-angiogenic therapy develops...
January 1, 2023: Biomedicines
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