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Dales RE

Nichola Foster, Rachel Kornhaber, Sarah McGarry, Fiona M Wood, Dale W Edgar
Heterotopic Ossification (HO) is a rare but severely debilitating complication after a burn. Despite there being literature of varying quality explaining the postulated pathological process, risk factors and treatment for HO, the individual experiences of adults diagnosed with HO following a burn, remains unreported. This study sought to explore and describe burn survivors' experiences of HO to gain a greater understanding of the clinical needs for this unique patient population. A phenomenological inquiry of five men and one woman selected through purposeful sampling collected in-depth interviews analysed using Colaizzi's method of data analysis...
April 13, 2017: Burns: Journal of the International Society for Burn Injuries
Heather A Wakelee, Scott Gettinger, Jeffrey Engelman, Pasi A Jänne, Howard West, Deepa S Subramaniam, Joseph Leach, Michael Wax, Yifah Yaron, Dale R Miles, Primo N Lara
PURPOSE: Cabozantinib is a multi-kinase inhibitor that targets MET, AXL, and VEGFR2, and may synergize with EGFR inhibition in NSCLC. Cabozantinib was assessed alone or in combination with erlotinib in patients with progressive NSCLC and EGFR mutations who had previously received erlotinib. METHODS: This was a phase Ib/II study (NCT00596648). The primary objectives of phase I were to assess the safety, pharmacokinetics, and pharmacodynamics and to determine maximum tolerated dose (MTD) of cabozantinib plus erlotinib in patients who failed prior erlotinib treatment...
March 28, 2017: Cancer Chemotherapy and Pharmacology
Vincent Wu, Edward A Sykes, Dale Mercer, Wilma M Hopman, Ephraim Tang
BACKGROUND: Square knots are the gold standard in hand-tie wound closure, but are difficult to reproduce in deep cavities, inadvertently resulting in slipknots. The reversing half-hitch alternating post (RHAP) knot has been suggested as an alternative owing to its nonslip nature and reproducibility in limited spaces. We explored whether the RHAP knot is noninferior to the square knot by assessing tensile strength. METHODS: We conducted 10 trials for each baseline and knot configuration, using 3-0 silk and 3-0 polyglactin 910 sutures...
April 1, 2017: Canadian Journal of Surgery. Journal Canadien de Chirurgie
Sheah Lin Lee, Nina Claire Dempsey-Hibbert, Dale Vimalachandran, Terence David Wardle, Paul A Sutton, John H H Williams
HSPC1 is a critical protein in cancer development and progression, including colorectal cancer (CRC). However, clinical trial data reporting the effectiveness of HSPC1 inhibitors on several cancer types has not been as successful as predicted. Furthermore, some N-terminal inhibitors appear to be much more successful than others despite similar underlying mechanisms. This study involved the application of three N-terminal HSPC1 inhibitors, 17-DMAG, NVP-AUY922 and NVP-HSP990 on CRC cells. The effects on client protein levels over time were examined...
March 2017: Cell Stress & Chaperones
Joyce Santos-Barbosa, Stephen T Lee, Daniel Cook, Dale R Gardner, Luis Henrique Viana, Nilva Ré
Monofluoroacetate (MFA) is a potent toxin that occurs in over 50 plant species in Africa, Australia, and South America and is responsible for significant livestock deaths in these regions. A gas chromatography-mass spectrometry (GC-MS) method for the analysis of MFA in plants based on the derivatization of MFA with n-propanol in the presence of sulfuric acid to form propyl fluoroacetate was developed. This method was equivalent to a currently employed high performance liquid chromatography-mass spectrometry (HPLC-MS) method for the analysis of MFA in plants...
January 28, 2017: Journal of Agricultural and Food Chemistry
José Ansín Agís, Fran Ramil, Dale R Calder
One new genus (Schizoplumularia) and three new species (Schizoplumularia vervoorti, S. geniculata and S. elegans) of plumulariids are recognized and described from large collections of plumularioid hydroids collected in New Caledonia and vicinity during several French expeditions. During taxonomic studies of these hydroids, colonies were compared with type material of Plumularia insignis Allman, 1883 and several other similar species-group taxa. As a result, three of the latter (P. flabellum Allman, 1883, P...
September 19, 2016: Zootaxa
L J Nelson, P K Miller, D Ashman
UNLABELLED: WHAT IS KNOWN ABOUT THE SUBJECT?: This paper describes crisis resolution/home treatment (CRHT) teams, which are part of mental health services in the United Kingdom. CRHT is expected to assist individuals in building resilience and work within a recovery approach. WHAT THIS PAPER ADDS TO EXISTING KNOWLEDGE?: This paper arises from an interview with one individual, Dale, as part of a larger study exploring service users' experiences of CRHT. It adds to the body of narrative knowledge in CRHT through Dale's co-authorship of this paper, reflecting on his original interview 4 years later, with co-authors providing critical interpretation of his experience, in turn supported by cognate literature...
August 2016: Journal of Psychiatric and Mental Health Nursing
Sze-Ann Woon, Dale Fisher
BACKGROUND: There is no more challenging a group of pharmaceuticals than antimicrobials. With the antibiotic era came great optimism as countless deaths were prevented from what were previously fatal conditions. Although antimicrobial resistance was quickly identified, the abundance of antibiotics entering the market helped cement attitudes of arrogance as the "battle against pestilence appeared won". Opposite emotions soon followed as many heralded the return of the pre-antibiotic era, suggesting that the "antibiotic pipeline had dried up" and that our existing armament would soon be rendered worthless...
2016: BMC Medicine
Jeremy Dale, Rachel Potter, Katherine Owen, Jonathan Leach
BACKGROUND: The general practice (GP) workforce in England is in crisis, with declining morale and job satisfaction, increasing early retirement and declining interest in training to become a GP. We recently reported on factors that are influencing this, with appraisal and revalidation emerging as an unexpected finding; 28.6 % of GPs stating an intention to leave general practice within the next 5 years included this as 'very important' or 'important' to their decision. In this study we undertook a secondary analysis to identify how the experience of appraisal and revalidation might be influencing intentions to leave general practice...
2016: BMC Family Practice
Hwee Weng Dennis Hey, Li Wen Nathaniel Ng, Chuen Seng Tan, Dale Fisher, Anupama Vasudevan, Ka-Po Gabriel Liu, Joseph Shantakumar Thambiah, Naresh Kumar, Leok-Lim Lau, Hee-Kit Wong, Paul Anantharajah Tambyah
STUDY DESIGN: A retrospective, cohort study of 84 patients with deep spine infection managed at a major tertiary hospital over 14 years with a minimum follow up of 2 years. OBJECTIVE: To determine the role of instrumentation in spines with deep infection. SUMMARY OF BACKGROUND DATA: It is often believed that implants should not be inserted in patients with deep spine infection because of the risk of persistent or recurrent infection. However, there are often concerns about spinal stability and a paucity of evidence to guide clinical practice in this field...
April 15, 2017: Spine
Alyssa J Rolfe, Dale B Bosco, Jingying Wang, Richard S Nowakowski, Jianqing Fan, Yi Ren
BACKGROUND: The single-stranded RNA Flavivirus, Zika virus (ZIKV), has recently re-emerged and spread rapidly across the western hemisphere's equatorial countries, primarily through Aedes mosquito transmission. While symptoms in adult infections appear to be self-limiting and mild, severe birth defects, such as microcephaly, have been linked to infection during early pregnancy. Recently, Tang et al. (Cell Stem Cell 2016, doi: 10.1016/j.stem.2016.02.016) demonstrated that ZIKV efficiently infects induced pluripotent stem cell (iPSC) derived human neural progenitor cells (hNPCs), resulting in cell cycle abnormalities and apoptosis...
2016: Cell & Bioscience
Thomas Möller, Frédérique Bard, Anindya Bhattacharya, Knut Biber, Brian Campbell, Elena Dale, Claudia Eder, Li Gan, Gwenn A Garden, Zoë A Hughes, Damien D Pearse, Roland G W Staal, Faten A Sayed, Paul D Wes, Hendrikus W G M Boddeke
Minocycline, a second generation broad-spectrum antibiotic, has been frequently postulated to be a "microglia inhibitor." A considerable number of publications have used minocycline as a tool and concluded, after achieving a pharmacological effect, that the effect must be due to "inhibition" of microglia. It is, however, unclear how this "inhibition" is achieved at the molecular and cellular levels. Here, we weigh the evidence whether minocycline is indeed a bona fide microglia inhibitor and discuss how data generated with minocycline should be interpreted...
October 2016: Glia
Tereza Lanitis, Robert Leipold, Melissa Hamilton, Dale Rublee, Peter Quon, Chantelle Browne, Alexander T Cohen
PURPOSE: To assess the cost-effectiveness of apixaban versus rivaroxaban, low-molecular-weight heparin (LMWH)/dabigatran, and LMWH/vitamin K antagonist (VKA) for the initial treatment and prevention of recurrent thromboembolic events in patients with venous thromboembolism (VTE). METHODS: A Markov model was developed to evaluate the pharmacoeconomic effect of 6 months of treatment with apixaban versus other anticoagulants over a lifetime horizon. Network meta-analyses were conducted using the results of the Apixaban after the Initial Management of Pulmonary Embolism and Deep Vein Thrombosis with First-Line Therapy (AMPLIFY), EINSTEIN-pooled, and RE-COVER I and II trials for the following end points: recurrent VTE, major bleeds, clinically relevant non-major bleeds, and treatment discontinuations...
March 2016: Clinical Therapeutics
Mark Ruzmetov, Dale M Geiss, Jitendra J Shah, Randall S Fortuna, Karl F Welke
BACKGROUND AND AIM OF THE STUDY: In patients undergoing the Ross procedure, the right ventricular outflow tract (RVOT) conduit is inserted in an orthotopic position rather than in the more heterotopic position used in the repair of complex congenital RVOT obstruction. The study aim was to compare the authors' institutional mid-term experience of large-sized homografts (>19 mm) in patients with Ross and non-Ross RVOT reconstructions. METHODS: The outcome was reviewed of all homografts implanted for Ross (n = 72) or non-Ross (n = 64) RVOT reconstruction at a single center between 1993 and 2012...
July 2015: Journal of Heart Valve Disease
Dale R Calder, William S Johnson
The binomen Nemopsis gibbesii McCrady, 1859, originally applied to a species of hydromedusa and its supposed hydroid from South Carolina, USA, has been known for more than a century to encompass two species. The medusa stage is conspecific with that of Nemopsis bachei L. Agassiz, 1849, while the hydroid stage is referable to the genus Margelopsis Hartlaub, 1897. Both that hydroid, and the medusa stage now subjectively linked to it, are commonly assigned to M. gibbesii. With no type having ever been designated for McCrady's species, a lectotype is designated to stabilize nomenclature of the species and serve as the standard for application of the name...
2015: Zootaxa
Fabian Diaz, Kenneth Bondiolli, Dale Paccamonti, Glen T Gentry
Pregnancy rates after cryopreservation of large equine blastocyst stage embryos have remained lower than other domesticated livestock species. It is generally accepted that the embryonic capsule is the primary barrier to cryoprotectant entry into the embryo proper and techniques need to be developed to circumvent this obstacle. Therefore, the objective of this study was to develop an efficient Day 8 equine embryo cryopreservation protocol through blastocyst micromanipulation and vitrification. Grade 1 and 2 embryos recovered from mares (n = 15) 8 days after ovulation were used in these experiments...
March 15, 2016: Theriogenology
Dale L Bailey, Thomas M Hennessy, Kathy P Willowson, E Courtney Henry, David L H Chan, Alireza Aslani, Paul J Roach
BACKGROUND: Advances in gamma camera technology and the emergence of a number of new theranostic radiopharmaceutical pairings have re-awakened interest in in vivo quantification with single-photon-emitting radionuclides. We have implemented and validated methodology to provide quantitative imaging of (177)Lu for 2D whole-body planar studies and for 3D tomographic imaging with single-photon emission computed tomography (SPECT)/CT. METHODS: Whole-body planar scans were performed on subjects to whom a known amount of [(177)Lu]-DOTA-octreotate had been administered for therapy...
December 2015: EJNMMI Physics
Megan Dale, Ailish Higgins, Grace Carolan-Rees
In current clinical practice, peripherally inserted central catheters (PICCs) are typically inserted using external anatomical measurements and a confirmatory chest X-ray, or using fluoroscopy. The Sherlock 3CG(®) Tip Confirmation System (TCS) allows magnetic tracking of the PICC tip during insertion and confirmation of the final location using ECG, meaning that most patients will not require a chest X-ray or fluoroscopy. The Sherlock 3CG(®) TCS was evaluated in 2014 by the UK National Institute for Health and Care Excellence (NICE) as part of the Medical Technologies Evaluation Programme...
February 2016: Applied Health Economics and Health Policy
Nariman Sepehrvand, Yinggan Zheng, Paul W Armstrong, Robert Welsh, Shaun G Goodman, Wayne Tymchak, Fadi Khadour, Michael Chan, Dale Weiss, Justin A Ezekowitz
BACKGROUND: Adjudication by an adjudication committee in clinical trials plays an important role in the assessment of outcomes. Controversy exists regarding the utility of adjudication committee versus site-based assessments and their relationship to subsequent clinical events. METHODS: This study is a secondary analysis of the Providing Rapid Out of Hospital Acute Cardiovascular Treatment-3 trial, which randomized patients with chest pain or shortness of breath for biomarker testing in the ambulance...
April 2016: Clinical Trials: Journal of the Society for Clinical Trials
Dale Block
No abstract text is available yet for this article.
November 2014: Physician Leadership Journal
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