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Lymphoma FDG PET/CT

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https://www.readbyqxmd.com/read/27904443/prognosis-estimation-under-the-light-of-metabolic-tumor-parameters-on-initial-fdg-pet-ct-in-patients-with-primary-extranodal-lymphoma
#1
Kursat Okuyucu, Sukru Ozaydın, Engin Alagoz, Gokhan Ozgur, Semra Ince, Fahrettin Guven Oysul, Ozlem Ozmen, Murat Tuncel, Mustafa Ozturk, Nuri Arslan
BACKGROUND: Non-Hodgkin's lymphomas arising from the tissues other than primary lymphatic organs are named primary extranodal lymphoma. Most of the studies evaluated metabolic tumor parameters in different organs and histopathologic variants of this disease generally for treatment response. We aimed to evaluate the prognostic value of metabolic tumor parameters derived from initial FDG-PET/CT in patients with a medley of primary extranodal lymphoma in this study. PATIENTS AND METHODS: There were 67 patients with primary extranodal lymphoma for whom FDG-PET/CT was requested for primary staging...
December 1, 2016: Radiology and Oncology
https://www.readbyqxmd.com/read/27901328/prognostic-value-of-interim-fdg-pet-ct-in-patients-older-than-60-years-with-diffuse-large-b-cell-lymphoma-treated-by-pmitcebo-plus-rituximab-comparison-between-deauville-5-point-scale-and-international-harmonization-project-criteria
#2
Naelle Lombion, Philippe Robin, Adrian Tempescul, Pierre Y LE Roux, Ulrike Schick, Gaëlle Guillerm, Jean C Ianotto, Christian Berthou, Pierre Y Salaün, Ronan Abgral
BACKGROUND: Advanced age is an independent poor prognostic factor of diffuse large B-cell lymphoma. PMitCEBO is an alternative to CHOP to decrease side effects in elderly patients. Many studies have shown prognostic value of an interim FDG PET-CT to predict survival. A recent consensus (ICML, Lugano 2013) has suggested using the 5-point scale Deauville criteria instead of those of the international harmonization project (IHP) to visually assess the response on interim PET. The objective of this study was to evaluate the prognostic value of an interim FDG PET-CT in patients older than 60 with treated DLBCL and to compare IHP and 5-PS Deauville visual interpretation to predict survival...
November 30, 2016: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27882275/a-case-of-an-enigmatic-pulmonary-infiltrate
#3
Uroosa Ibrahim, Amina Saqib, Michel Chalhoub, Jean Paul Atallah
The differential diagnosis of a pulmonary mass in an immunosuppressed host with a history of cancer is broad and includes malignant, infectious and inflammatory etiologies. Mycobacterium avium complex (MAC) is a rare cause of opportunistic infection in susceptible individuals that can present as either localized or disseminated disease. On radiologic studies, the pulmonary disease can manifest as heterogeneous linear or nodular densities, a mass-like lesion, or thin-walled cavitary lesions. We present the case of pulmonary MAC in a patient with a history of lung cancer requiring lobectomy, and splenic lymphoma being treated with chemotherapy, presenting with extreme fatigue and a fludeoxyglucose (FDG)-avid mass on positron emission tomography-computed tomography (PET-CT)...
October 13, 2016: Curēus
https://www.readbyqxmd.com/read/27875758/beyond-the-lymph-nodes-fdg-pet-ct-in-primary-extranodal-lymphoma
#4
REVIEW
Kin Man Sin, Stanton King Dat Ho, Brian Yung Kong Wong, Harry Gill, Pek-Lan Khong, Elaine Yuen Phin Lee
Extranodal lymphoma can be the primary presentation or secondary to systemic involvement of lymphoma. 2-(fluorine-18) fluoro-2-deoxy-d-glucose positron emission tomography with computer tomography (FDG-PET/CT) is useful in detecting extranodal sites during staging, treatment response assessment or recurrence detection in patients with lymphoma. In this article, we reviewed the imaging features and FDG avidity of primary extranodal lymphoma of various organs and systems on FDG-PET/CT, demonstrating the pearls and pitfalls of FDG-PET/CT in evaluating this disease entity and cross-referencing to other imaging modalities that aid in diagnosis and management...
November 16, 2016: Clinical Imaging
https://www.readbyqxmd.com/read/27846000/diagnostic-value-of-68ga-psma-11-pet-ct-imaging-of-brain-tumors-preliminary-analysis
#5
Arun Sasikumar, Ajith Joy, M R A Pillai, Raviteja Nanabala, Muhammed Anees K, P G Jayaprakash, Jayaprakash Madhavan, Suresh Nair
OBJECTIVE: To evaluate the feasibility of using Ga PSMA-11 PET/CT for imaging brain lesions and its comparison with F-FDG. METHODS: Ten patients with brain lesions were included in the study. Five patients were treated cases of glioblastoma with suspected recurrence. F-FDG and Ga PSMA-11 brain scans were done for these patients. Five patients were sent for assessing the nature (primary lesion/metastasis) of space occupying lesion in brain. They underwent whole body F-FDG PET/CT scan and a primary site elsewhere in the body was ruled out...
January 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/27835875/prognostic-value-of-total-lesion-glycolysis-of-baseline-18f-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-in-diffuse-large-b-cell-lymphoma
#6
Mingge Zhou, Yumei Chen, Honghui Huang, Xiang Zhou, Jianjun Liu, Gang Huang
PURPOSE: We evaluated the prognostic value of total lesion glycolysis (TLG) measured in baseline 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) in diffuse large B-cell lymphoma (DLBCL) treated with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP). METHODS: A total of 91 patients with newly diagnosed DLBCL underwent 18F-FDG PET/CT scans before R-CHOP therapy. Metabolic tumor volume (MTV) was measured with the marginal threshold of normal liver mean standard uptake value (SUVmean) plus 3 standard deviations (SD)...
November 7, 2016: Oncotarget
https://www.readbyqxmd.com/read/27832711/discussion-of-18f-fdg-pet-ct-imaging-characteristics-and-diagnostic-values-of-angioimmunoblastic-t-cell-lymphoma
#7
Dan Shao, Qiang Gao, Chang-Hong Liang, Shu-Xia Wang
The aim of this study was to discuss (18)F-FDG PET/CT imaging characteristics and diagnostic values of angioimmunoblastic T-cell lymphoma (AITL). The PET/CT features of 24 cases of pathologically confirmed AITL were analyzed. The individual and total diagnostic values of 13 sites using computed tomography (CT) and positron emission tomography (PET)/CT were calculated. The maximum standard uptake value (SUVmax) of lesions with lymph node infiltration and extranodal organ infiltration were 5.4-25.1 (median, 9...
November 10, 2016: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/27824969/the-early-diagnosis-of-testicular-natural-killer-t-cell-lymphoma
#8
Pei Shu, Wenwu Ling, Chenjing Zhu, Jianchao Wang, Chong Jiang, Weiwei Zhang, Yue Xiao, Xuelei Ma
Testicular natural killer/T-cell lymphoma is a rare aggressive extranodal lymphoma associated with Epstein-Barr virus infection. Time to diagnose is crucial as the disease is rapidly progressive and fatal. Early suspicion is documented by imaging studies and testicular biopsies which are key factors for diagnosing testicular natural killer/T-cell lymphoma. However, no reports have described the results of imaging studies. In this paper, contrast-enhanced ultrasonography (CEUS), fluorine-18-fuorodexoyglucose-positron emission tomography/computed tomography ((18)F-FDG PET/CT) and tumor biopsies were all diagnostic of testicular natural killer/T-cell lymphoma...
November 8, 2016: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/27813622/18f-fdg-pet-ct-in-the-diagnosis-of-an-extranodal-relapse-of-diffuse-large-b-cell-lymphoma-dlbcl-a-clinical-case-with-a-literature-review
#9
Borislav Chaushev, Ilina Micheva, Merilin Mechmed, Boyan Balev, Yana Bocheva, Darina Ivanova, Ivan Krasnaliev, Rumena Lozanova, Anelia Klisarova, Pavel Bochev, Jivka Dancheva
Extranodal lymphoma, secondary to or accompanying nodal disease is uncommon, but not unusual finding. 18-Fluorodeoxyglucose positron emission tomography (18F-FDG PET/CT) imaging has an essential role in the staging of lymphoma, in treatment response monitoring, and in detection of recurrence. We present a case of a 52-year-old man with generalized diffuse large B-cell lymphoma (DLBCL) with multiple extranodal sites involvement detected by 18F-FDG PET/CT. With this clinical case we demonstrate that 18F-FDG PET-CT is a more effective technique than CE-CT for the evaluation of viable extranodal involvement of the diffuse large B-cell lymphoma (DLBCL) and should be combined in the monitoring of DLBCL...
2016: Nuclear Medicine Review. Central & Eastern Europe
https://www.readbyqxmd.com/read/27811123/clinical-indications-impact-on-management-fourth-and-subsequent-post-therapy-follow-up-fdg-pet-ct-scans-in-oncology-patients
#10
Mehdi Taghipour, Charles Marcus, Sara Sheikhbahaei, Esther Mena, Shwetha Prasad, Abhinav K Jha, Lilja Solnes, Rathan M Subramaniam
INTRODUCTION: The Centers for Medicare and Medicaid Services (CMS) coverage includes three post-therapy FDG-PET/CT scans per patient and per tumor type. Any additional follow-up FDG-PET/CT will be reimbursed at the discretion of a local Medicare administrator, if deemed medically necessary. This study aims to investigate common clinical indications for performing a fourth or additional follow-up FDG-PET/CT scans which could impact management of patients. METHODS: This was a retrospective institutional review of 433 oncology patients (203 male, mean age 55 years), including a total of 1,659 fourth or subsequent follow-up PET/CT scans after completion of primary treatment...
November 3, 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/27810790/evaluation-of-decreased-uptake-of-18f-fluorodeoxyglucose-in-the-cerebral-cortex-of-patients-with-intracranial-non-hodgkin-s-lymphoma-lesions-through-pet-ct
#11
Qingbo Zhang, Tian Tian, Li Wang, Hongxia Qiu, Danming Li
BACKGROUND: This study aims to investigate whether basal ganglia can be utilised as reference for measuring ratios between standardised uptake values (SUV), namely, SUVmax and SUVmean, of 18F-fluoro-deoxyglucose (18F-FDG) uptake, in the ipsilateral cerebral cortex and basal ganglia of patients with non-Hodgkin's lymphoma lesions. METHODS: Fifty-three patients with pathologically confirmed highly metabolic non-Hodgkin's lymphoma were retrospectively analysed; these patients were subjected to treatment strategy and underwent positron emission tomography/computed tomography (PET/CT)...
October 31, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27805919/fdg-avid-intrathecal-inflammation-following-administration-of-intrathecal-methotrexate
#12
Molly P Hogan, Joseph Osborne, Gary A Ulaner
Intrathecal methotrexate is a standard option for central nervous system-directed therapy in patients with stage III and IV diffuse large B-cell lymphoma. We present a case of a 50-year-old man with stage IV diffuse large B-cell lymphoma with widespread lymphomatous involvement including the central nervous system, who received 7 doses of intrathecal methotrexate via Ommaya catheter. Posttherapy F-FDG-PET/CT imaging demonstrated diffuse, intense intrathecal FDG avidity, without correlative findings on MR spinal imaging...
November 1, 2016: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/27800198/a-case-report-of-neurosarcoidosis-presenting-as-a-lymphoma-mimic
#13
Gurcharanjeet Kaur, Lauren Cameron, Olga Syritsyna, Patricia Coyle, Agnes Kowalska
Objective. To describe a unique presentation of neurosarcoidosis. Background. Central nervous system involvement is rare in sarcoidosis. Sarcoidosis can be severe and can be mistaken for systemic lymphoma. Case Description. A 55-year-old right-handed white male with past medical history of obstructive sleep apnea, Raynaud's disease, and Hashimoto's thyroiditis was noted to have cognitive decline over a duration of few weeks and 20 lb weight loss. His neurologic exam (including cranial nerves) was normal except for five-minute recall...
2016: Case Reports in Neurological Medicine
https://www.readbyqxmd.com/read/27795508/update-on-the-use-of-fdg-pet-ct-in-malignant-lymphoma
#14
Takashi Terauchi
This article aims to explain the current status of FDG-PET/CT in malignant lymphoma management by reviewing the new recommendations for evaluation, staging, and response assessment in patients with malignant lymphoma, published as the Lugano Classification in 2014. FDG-PET/CT was formally incorporated into standard staging for FDG-avid lymphoma in this new classification. Nearly all subtypes of malignant lymphoma are FDG-avid. In staging, the increased FDG uptake compatible with lymphoma is considered to represent involvement of lymphoma, regardless of size, and the FDG-avid lesion is potentially a good biopsy target...
2016: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://www.readbyqxmd.com/read/27795295/adrenal-lymphoma-presentation-management-and-prognosis
#15
C Laurent, O Casasnovas, L Martin, A Chauchet, H Ghesquieres, G Aussedat, L M Fornecker, S Bologna, S Borot, K Laurent, B Bouillet, B Verges, J-M Petit
AIM: This study aimed to identify the clinical, radiological and prognostic features of primary adrenal lymphoma (PAL) in order to diagnose the disease more accurately. MATERIALS AND METHODS: A retrospective multi-centre study was conducted on the clinical, biological and radiological features as well as the treatment and overall survival outcomes in PAL. RESULTS: Between 1994 and 2014, 28 patients from five regions of eastern France were diagnosed with primary adrenal lymphoma...
October 18, 2016: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/27792043/the-role-of-18f-fdg-pet-and-pet-ct-in-the-evaluation-of-primary-cutaneous-lymphoma
#16
Lin Qiu, Guojian Tu, Jing Li, Yue Chen
Primary cutaneous lymphoma (PCL) is the second most common type of extranodal non-Hodgkin lymphoma, including both cutaneous T-cell and B-cell lymphomas. PCL comprises numerous subtypes and thus has myriad clinical presentations in the skin and subcutaneous tissues. Accurate classification and staging are important for making treatment recommendations for PCL and will further impact patient prognosis significantly. We review the role of fluorine-18-fluorodeoxyglucose (F-FDG) PET (F-FDG PET) and F-FDG PET with computed tomography (CT) in the diagnosis, staging, tumor biological evaluation, treatment response assessment, and early recurrence surveillance of PCL...
October 27, 2016: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/27784367/-manifestations-of-pet-ct-imaging-in-primary-central-nervous-system-lymphoma
#17
Liang Yin, Zhi-Chun Lin, Jian-Lan Yue, Shi-Ming Huang, Wei Chen
OBJECTIVE: To investigate the PET/CT features of primary central nervous system lymphoma(PCNSL). METHODS: A retrospective analysis of PET/CT imaging manifestations and clinical data was performed in 4 PCNSL cases which were confirmed by surgery or stereotactic pathologic biopsy. RESULTS: The pathologic biopsy in 4 patients all showed diffuse large B cell lymphoma with a total of 8 lesions. All cases were performed with (18)F-FDG PET/CT imaging except 1 patient simultaneously with (18)F-FLT PET/CT imaging in the brain...
October 2016: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/27754905/baseline-total-metabolic-tumor-volume-measured-with-fixed-or-different-adaptive-thresholding-methods-equally-predicts-outcome-in-peripheral-t-cell-lymphoma
#18
Anne-Segolene Cottereau, Sebastien Hapdey, Loic Chartier, Romain Modzelewski, Olivier Casasnovas, Emmanuel Itti, Herve Tilly, Pierre Vera, Michel A Meignan, Stéphanie Becker
: To compare in a large series of Peripheral T cell lymphoma (PTCL), as a model of diffuse disease, the prognostic value of baseline Total Metabolic Tumor Volume (TMTV) measured on FDG-PET/CT with adaptive thresholding methods to TMTV measured with a fixed 41% SUVmax threshold method. METHODS: 106 patients with PTCL, staged with a PET/CT were enrolled from 5 LYSA centers. In this series TMTV computed with the 41% SUVmax threshold is a strong predictor of outcome (Ann Oncol, 2016)...
October 6, 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/27754902/post-treatment-pet-ct-rather-than-interim-pet-ct-using-deauville-criteria-predicts-outcome-in-pediatric-hodgkin-lymphoma-a-prospective-study-comparing-pet-ct-versus-conventional-imaging
#19
Sameer Bakhshi, Sainath Bhethanabhotla, Rakesh Kumar, Krishankant Agarwal, Punit Sharma, Sanjay Thulkar, Arun Malhotra, Deepa Dhawan, Sreenivas Vishnubhatla
BACKGROUND: Data about significance of (18)F-FDG positron emission tomography (PET) at interim assessment and end of treatment in pediatric Hodgkin lymphoma (HL) are limited. METHODS: Patients (≤18 years) with HL were prospectively evaluated with contrast-enhanced computed tomography (CECT) and PET combined with low-dose CT(PET-CT) at baseline, post 2 cycles of chemotherapy and post completion of treatment. Revised international working group criteria (RIW) and Deauville (DA) five point-scale for response assessment by PET-CT were used...
October 6, 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/27742070/richter-s-syndrome-novel-and-promising-therapeutic-alternatives
#20
Davide Rossi
Richter's syndrome (RS) is the development of an aggressive lymphoma in patients with a previous or concomitant diagnosis of chronic lymphocytic leukemia (CLL). The incidence rate for RS is ∼0.5% per year of observation. In the presence of clinical suspicious of RS, diagnosis of transformation and choice of the site of biopsy may take advantage of (18)FDG PET/CT. Molecular lesions of tumor suppression regulators (TP53), cell cycle (CDKN2A) and cell proliferation (NOTCH1, MYC) overall account for ∼90% of RS and may be responsible for its aggressive clinical phenotype...
March 2016: Best Practice & Research. Clinical Haematology
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