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Lymphoma FDG PET/CT

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https://www.readbyqxmd.com/read/28090627/fdg-pet-for-early-response-assessment-in-lymphomas-part-2-diffuse-large-b-cell-lymphoma-use-of-quantitative-pet-evaluation
#1
REVIEW
Bruce D Cheson, Lale Kostakoglu
In Part 1, we reviewed the role of interim positron emission tomography (PET)/CT scans in Hodgkin lymphoma. In advanced Hodgkin lymphoma, interim PET is a useful prognostic tool that can be used to implement risk-adapted therapy with potential benefits for both patients who have negative interim scans and those whose scans are positive. Interim PET/CT has not shown as encouraging results in diffuse large B-cell lymphoma (DLBCL), with the exception of germinal center B-cell DLBCL. Thus, quantitative methods of interpreting interim PET scans have been pursued in an effort to improve their predictive value...
January 15, 2017: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/28090622/fdg-pet-for-early-response-assessment-in-lymphomas-part-1-hodgkin-lymphoma
#2
REVIEW
Bruce D Cheson, Lale Kostakoglu
Interim positron emission tomography (PET)/CT has shown encouraging results when used as a prognostic tool early in the course of treatment of advanced Hodgkin lymphoma, allowing for a reduction in treatment for patients with favorable characteristics, while suggesting a benefit from changing therapy for those with a positive scan. For patients with limited disease, a negative scan allows for a decrease in treatment; however, the benefits for those patients whose scans are positive are less certain. Here we critically analyze the role of PET/CT in the early assessment of Hodgkin lymphoma...
January 15, 2017: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/28068241/chemotherapy-response-assessment-by-fdg-pet-ct-in-early-stage-classical-hodgkin-lymphoma-moving-beyond-the-five-point-deauville-score
#3
Sarah A Milgrom, Wenli Dong, Mani Akhtari, Grace L Smith, Chelsea C Pinnix, Osama Mawlawi, Eric Rohren, Naveen Garg, Hubert Chuang, Zeinab Abou Yehia, Jay P Reddy, Jillian R Gunther, Joseph D Khoury, Tina Suki, Eleanor M Osborne, Yasuhiro Oki, Michelle Fanale, Bouthaina S Dabaja
PURPOSE: In early-stage classical Hodgkin lymphoma, fluorodeoxyglucose positron emission tomography (PET)-computed tomography (CT) scans are performed routinely after chemotherapy, and the 5-point Deauville score is used to report the disease response. We hypothesized that other PET-CT parameters, considered in combination with Deauville score, would improve risk stratification. METHODS AND MATERIALS: Patients treated for stage I to II Hodgkin lymphoma from 2003 to 2013, who were aged ≥18 years and had analyzable PET-CT scans performed before and after chemotherapy, were eligible...
February 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28062598/fact-sheet-about-interim-and-end-of-treatment-18f-fdg-pet-ct-in-lymphoma
#4
Hugo J A Adams, Thomas Christian Kwee
No abstract text is available yet for this article.
January 6, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28054283/mediastinal-seminoma-associated-with-multilocular-thymic-cyst
#5
Masato Inui, Jun-Ichi Nitadori, Shogo Tajima, Takahusa Yoshioka, Noriko Hiyama, Takeyuki Watadani, Aya Shinozaki-Ushiku, Kazuhiro Nagayama, Masaki Anraku, Masaaki Sato, Masashi Fukayama, Jun Nakajima
An asymptomatic 26-year-old man received an annual medical check-up, and chest X-ray showed a protrusion of the aortopulmonary window. Chest computed tomography (CT) revealed an anterior mediastinal tumor and cysts with thin wall and septum enhancement. The preoperative diagnosis was cystic thymoma or malignant lymphoma. We performed total resection of the tumor through a median sternotomy. The pathological findings revealed seminoma, positive for c-kit stain, and multilocular thymic cysts. Cysts were lined by normal squamous epithelium and no seminoma cells were located on their surface...
December 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/28047623/su-f-r-13-decoding-18f-fdg-uptake-heterogeneity-for-primary-and-lymphoma-tumors-by-using-texture-analysis-in-pet-images
#6
C Ma, Y Yin
PURPOSE: To explore 18F-FDG uptake heterogeneity of primary tumor and lymphoma tumor by texture features of PET image and quantify the heterogeneity difference between primary tumor and lymphoma tumor. METHODS: 18 patients with primary tumor and lymphoma tumor in lung cancer were enrolled. All patients underwent whole-body 18F-FDG PET/CT scans before treatment. Texture features, based on Gray-level Co-occurrence Matrix, second and high order matrices are extracted from code using MATLAB software to quantify 18F-FDG uptake heterogeneity...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046973/su-f-r-14-pet-based-radiomics-to-predict-outcomes-in-patients-with-hodgkin-lymphoma
#7
J Lee, M Aristophanous, M Akhtari, S Milgrom, D Bouthaina, C Pinnix, S Narang, A Rao, L Court, G Smith
PURPOSE: To identify PET-based radiomics features associated with high refractory/relapsed disease risk for Hodgkin lymphoma patients. METHODS: A total of 251 Hodgkin lymphoma patients including 19 primary refractory and 9 relapsed patients were investigated. All patients underwent an initial pre-treatment diagnostic FDG PET/CT scan. All cancerous lymph node regions (ROIs) were delineated by an experienced physician based on thresholding each volume of disease in the anatomical regions to SUV>2...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28033252/18f-fdg-super-bone-marrow-uptake-a-highly-potent-indicator-for-the-malignant-infiltration
#8
Mohammed Shah Alam, Lilan Fu, Yun-Yan Ren, Hu-Bing Wu, Quan-Shi Wang, Yan-Jiang Han, Wen-Lan Zhou, Hong-Sheng Li, Zhen Wang
The present study was performed to investigate whether the markedly 2-deoxy-2-(fluorine-18) fluoro-D-glucose (F-FDG) uptake in the bone marrow (BM) is a presentation of malignant infiltration (MI).Super bone marrow uptake (super BMU) was used to name the markedly F-FDG uptake on BM, which was similar to or higher than that of the brain. From April 2008 to December 2015, 31 patients with such presentation were retrospectively reviewed. The F-FDG uptake was semiquantified using SUVmax and BM to cerebellum (BM/C) ratio...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28013449/follicular-lymphoma-related-colitis-resembling-ulcerative-colitis
#9
Takahiro Zenda, Noriharu Nakagawa, Hiroyuki Maruyama, Tamao Endo, Kotaro Higashi, Junpei Yamamoto, Keigo Komai, Kishichiro Watanabe, Ichiro Araki
Among the various manifestations of colonic involvement in malignant lymphomas, an ulcerative colitis-like appearance is rare. Herein, we describe a case in which extranodal colonic involvement resembled ulcerative colitis in a patient with advanced follicular lymphoma. A 59-year-old Japanese man with diarrhea and body weight loss was referred to our hospital. Computed tomography (CT) revealed systemic lymphadenopathy, splenomegaly, and thickening of the sigmoid colon and rectum walls. (18)F-fluorodeoxy-glucose positron emission tomography ((18)F-FDG-PET/CT) revealed intense tubular (18)F-FDG accumulation extending from the rectum to the colon at the hepatic flexure and much weaker accumulation in the systemic lymph nodes, bone marrow, and spleen...
December 24, 2016: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/28004400/role-of-fluorine-18-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-in-evaluating-breast-mucosa-associated-lymphoid-tissue-lymphoma-a-case-series
#10
Domenico Albano, Giovanni Bosio, Emanuela Orlando, Francesco Bertagna
Mucosa-associated lymphatic tissue (MALT) lymphoma of the breast is an extremely rare disease; its pathogenesis is not clear because of the rarity of disease, and the best diagnostic method has yet to be established. The metabolic behavior of this lymphoma is not still clear because only a few case reports are present in literature describing the possible role of fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) in this field. This report presents 4 cases of women with histologically proven breast MALT lymphoma who underwent 7 18F-FDG PET/CT throughout the course of disease...
December 22, 2016: Hematological Oncology
https://www.readbyqxmd.com/read/27999884/frequency-of-high-blood-glucose-prior-to-fdg-pet
#11
Amir H Khandani, Isabel M Bravo, Parth S Patel, Marijana Ivanovic, Deepa Kirk
PURPOSE: To assess the frequency of blood glucose level higher than 150 mg/dL in non-diabetic patients presenting for FDG PET. METHODS: We reviewed the electronic medical record (EMR) of all lymphoma patients who had at least one FDG PET/CT from July 1, 2014 through June 30, 2015. We extracted the blood glucose level at the time of the FDG PET during this 1-year time period and any previous PET scans these patients had. Patients' diabetic status was determined from EMR...
December 20, 2016: Abdominal Radiology
https://www.readbyqxmd.com/read/27997427/cat-scratch-disease-a-pitfall-for-lymphoma-evaluation-by-fdg-pet-ct
#12
Julien Dubreuil, Arthur Dony, Gilles Salles, Alexandra Traverse-Glehen, Francesco Giammarile, Andrea Skanjeti
FDG-PET/CT is a standard of care in staging and response assessment of Hodgkin lymphoma. Hence, it is important to recognize pitfalls owing to the potential therapeutic impact. We report a case of a 29-year-old woman affected by stage III bulky Hodgkin lymphoma. The interim FDG-PET/CT showed a complete metabolic response. After three new cycles of chemotherapy, the patient showed fever and lymphadenopathy at clinic examination, PET/CT revealed several FDG uptakes at lymph nodes in inguinal and iliac region...
December 16, 2016: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/27996313/prognostic-importance-of-bone-marrow-uptake-on-baseline-18-f-fdg-positron-emission-tomography-in-diffuse-large-b-cell-lymphoma
#13
Cigdem Soydal, Elif Berna Koksoy, Arzu Yasar, Ebru Turgal, Beyza Doganay Erdogan, Hakan Akbulut, Nuriye Ozlem Kucuk
AIM: To define the role of (18)F-flourodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) in the detection of bone marrow (BM) involvement in patients with diffuse large B cell lymphoma (DLBCL). MATERIALS AND METHODS: Fifty-four (mean age: 55.5 ± 18.3 years, 20 female and 34 male) DLBCL patients who underwent pretreatment (18)F-FDG PET/CT were included to the study. Focal or diffuse BM (18)F-FDG uptake that is higher than mediastinal blood pool uptake was accepted as positive...
December 2016: Cancer Biotherapy & Radiopharmaceuticals
https://www.readbyqxmd.com/read/27994685/intra-patient-variability-of-fdg-standardized-uptake-values-in-mediastinal-blood-pool-liver-and-myocardium-during-r-chop-chemotherapy-in-patients-with-diffuse-large-b-cell-lymphoma
#14
Soo Jeong Kim, Hyun Kyung Yi, Chae Hong Lim, Young Seok Cho, Joon Young Choi, Yearn Seong Choe, Kyung-Han Lee, Byung-Tae Kim, Seung Hwan Moon
PURPOSE: (18)F-fluorodeoxyglucose (FDG) PET/CT is useful for staging and evaluating treatment response in patients with diffuse large B-cell lymphoma (DLBCL). A five-point scale model using the mediastinal blood pool (MBP) and liver as references is a recommended method for interpreting treatment response. We evaluated the variability in standardized uptake values (SUVs) of the MBP, liver, and myocardium during chemotherapy in patients with DLBCL. METHODS: We analyzed 60 patients with DLBCL who received rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone (R-CHOP) treatment and underwent baseline, interim, and final FDG PET/CT scans...
December 2016: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27974685/prognostic-value-of-whole-body-suvmax-of-nodal-and-extra-nodal-lesions-detected-by-18f-fdg-pet-ct-in-extra-nodal-nk-t-cell-lymphoma
#15
Jin-Hua Liang, Chong-Yang Ding, Robert Peter Gale, Li Wang, Ji Xu, Xiao-Yan Qu, Lei Fan, Tian-Lv Li, Jian-Yong Li, Wei Xu
We analyzed data from 54 newly-diagnosed persons with extra-nodal natural killer/T-cell (NK/T) lymphoma, who had a pretreatment 18F-FDG PET/CT study, to determine whether the sum of SUVmax of all the nodal and extra-nodal lesions predicted progression-free survival (PFS) and/or overall survival (OS). Three models (WB1SUVmax, WB2SUVmax, WB3SUVmax) based on the basis of the sum of SUVmax of the whole-body SUVmax of 11 nodal and 10 extra-nodal lesions were tested. The discrimination value of these models was evaluated using time-dependent receiver-operator characteristic (ROC) curves and corresponding areas under the curve (AUC) in training and validation cohorts...
December 10, 2016: Oncotarget
https://www.readbyqxmd.com/read/27965911/occipital-hypometabolism-on-fdg-pet-ct-scan-in-a-child-with-hodgkin-s-lymphoma
#16
Inci Uslu Biner, Ebru Tatci, Ozlem Ozmen, Atila Gokcek, Haci Ahmet Demir, Nadide Basak Gulleroglu
It is known that Fluorodeoxyglucose (FDG) Positron Emission/Computed Tomography (PET/CT) images may be helpful for evaluation of brain function in newborns. Here we described the fluorine-18 [18-F] FDG PET/CT imaging findings of encephalomalacia due to perinatal asphyxia in a child with refractory Hodgkin's Lymphoma (HL) who underwent PET/CT scan to stage the primary disease. Prominent hypometabolism was incidentally detected in the occipital regions bilaterally apart from the FDG uptakes in the malign lymphatic infiltrations...
2016: Case Reports in Radiology
https://www.readbyqxmd.com/read/27955798/automatic-detection-and-classification-of-regions-of-fdg-uptake-in-whole-body-pet-ct-lymphoma-studies
#17
Lei Bi, Jinman Kim, Ashnil Kumar, Lingfeng Wen, Dagan Feng, Michael Fulham
[(18)F]-Fluorodeoxyglucose (FDG) positron emission tomography-computed tomography (PET-CT) scans of lymphoma patients usually show disease involvement as foci of increased radiotracer uptake. Existing methods for detecting abnormalities, model the characteristics of these foci; this is challenging due to the inconsistent shape and localization information about the lesions. Thresholding the degree of FDG uptake is the standard method to separate different sites of involvement. But may fragment sites into smaller regions, and may also incorrectly identify sites of normal physiological FDG uptake and normal FDG excretion (sFEPU) such as the kidneys, bladder, brain and heart...
December 2, 2016: Computerized Medical Imaging and Graphics: the Official Journal of the Computerized Medical Imaging Society
https://www.readbyqxmd.com/read/27941375/diffuse-subcutaneous-fat-involvement-in-a-marginal-zone-lymphoma
#18
Julien Dubreuil, Robin Noel, Jeremie Tordo, Gilles Salles, Andrea Skanjeti
Marginal zone lymphoma (MZL) is usually considered not avid for FDG. We report a case of a 57-year-old man with an MZL suspected for transformation. FDG-PET/CT showed a diffuse atypical involvement of subcutaneous fat, without sign suggestive for a transformation. No cutaneous involvement was clinically evident. A random subcutaneous biopsy was performed and showed the presence of MZL.
December 9, 2016: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/27936917/imaging-findings-of-childhood-b-cell-lymphoblastic-lymphoma-in-the-mental-region-a-case-report
#19
Phong Dai Lam, Ami Kuribayashi, Junichiro Sakamoto, Shin Nakamura, Hiroyuki Harada, Tohru Kurabayashi
Lymphoblastic lymphoma (LBL) is an uncommon neoplasm that accounts for about 5% of all non-Hodgkin's lymphomas. Approximately 90% of LBLs are of immature T-cell lineage, with B-cell lymphoblastic lymphoma (B-LBL) accounting for only about 10%. Due to the infrequency, the clinicopathological features and the imaging findings of B-LBL are not well defined. LBLs frequently affect extranodal sites. The most common site is skin, followed by bone, and the head and neck region is rarely involved. We report herein a case of childhood B-LBL occurring in the mental region, with emphasis on the findings of several imaging studies, including contrast-enhanced CT, MRI and FDG-PET/CT...
December 12, 2016: Dento Maxillo Facial Radiology
https://www.readbyqxmd.com/read/27904443/prognosis-estimation-under-the-light-of-metabolic-tumor-parameters-on-initial-fdg-pet-ct-in-patients-with-primary-extranodal-lymphoma
#20
Kursat Okuyucu, Sukru Ozaydın, Engin Alagoz, Gokhan Ozgur, Semra Ince, Fahrettin Guven Oysul, Ozlem Ozmen, Murat Tuncel, Mustafa Ozturk, Nuri Arslan
BACKGROUND: Non-Hodgkin's lymphomas arising from the tissues other than primary lymphatic organs are named primary extranodal lymphoma. Most of the studies evaluated metabolic tumor parameters in different organs and histopathologic variants of this disease generally for treatment response. We aimed to evaluate the prognostic value of metabolic tumor parameters derived from initial FDG-PET/CT in patients with a medley of primary extranodal lymphoma in this study. PATIENTS AND METHODS: There were 67 patients with primary extranodal lymphoma for whom FDG-PET/CT was requested for primary staging...
December 1, 2016: Radiology and Oncology
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