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Lymphoma FDG PET/CT

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https://www.readbyqxmd.com/read/28321090/splenic-marginal-zone-lymphoma-complicated-by-cold-agglutinin-disease
#1
Kiyosumi Ochi, Kazuaki Yokoyama, Nobuhiro Ohno, Yasunori Ota, Arinobu Tojo
Splenic marginal zone lymphoma (SMZL) is a rare low-grade B-cell lymphoma accounting for less than 1% of lymphoid neoplasms and is often associated with autoimmune disorders. A 48-year-old woman presented with severe anemia due to steroid-refractory cold agglutinin disease (CAD), and was referred to our hospital for management of progressive systemic illness and high fever. On admission, she showed elevated serum soluble IL-2R and mild splenomegaly. PET/CT revealed FDG accumulation in the spleen and bone. She was pathologically diagnosed as having splenic marginal zone lymphoma by splenectomy and received 8 cycles of rituximab every 2 weeks, resulting in marked improvement of anemia...
2017: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://www.readbyqxmd.com/read/28315904/prognostic-value-of-bone-marrow-18-f-fdg-uptake-on-pet-ct-in-lymphoma-patients-with-negative-bone-marrow-involvement
#2
Jeong Won Lee, Sang Cheol Lee, Han Jo Kim, Sang Mi Lee
OBJECTIVE: The study evaluated the significance of 18F fluorodeoxyglucose ((18)F-FDG) uptake of bone marrow (BM) for predicting progression-free survival (PFS) in lymphoma patients without BM involvement. SUBJECTS AND METHODS: Ninety-five patients with histopathologically proven lymphoma, 7 Hodgkin's lymphoma and 88 non-Hodgkin's lymphoma, who underwent (18)F-FDG positron emission tomography/computed tomography (PET/CT) and BM biopsy for staging work-up and 40 normal subjects were retrospectively enrolled...
March 20, 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28295218/-18-f-fdg-pet-ct-in-the-staging-and-management-of-indolent-lymphoma-a-prospective-multicenter-pet-registry-study
#3
Ur Metser, Jill Dudebout, Tara Baetz, David C Hodgson, Deanna L Langer, Pamela MacCrostie, Victor Mak, Noam Tau
BACKGROUND: To measure the clinical impact of pretreatment fludeoxyglucose positron emission tomography/computed tomography (PET/CT) on the staging and management of apparent limited stage indolent lymphoma being considered for curative radiation therapy. METHODS: We conducted a prospective multicenter registry study that included 197 patients accrued between May 1, 2012, and December 31, 2015. Pre-PET/CT stage, determined by clinical and CT data, was documented...
March 13, 2017: Cancer
https://www.readbyqxmd.com/read/28291005/the-correlation-between-pre-treatment-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-parameters-and-clinical-prognostic-factors-in-pediatric-hodgkin-lymphoma
#4
Ebru Tatcı, İnci Uslu Biner, Suna Emir, Hikmet Gülşah Tanyıldız, Özlem Özmen, Engin Alagöz, Atila Gökçek, Gürses Şahin
OBJECTIVE: To compare standardized uptake values (SUV) derived from pre-treatment (18)F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) imaging and clinical prognostic factors in pediatric patients with Hodgkin lymphoma (HL). METHODS: Pre-treatment FDG PET/CT findings of 28 children with HL were evaluated in this retrospective study. Metabolic tumor volume (MTV), SUVmax normalized by weight (SUVweight), lean body mass (SUVlbm), body surface area (SUVbsa) and plasma glucose levels of tumors (SUVglucose) were calculated using pre-treatment FDG PET/CT scan images...
February 5, 2017: Molecular Imaging and Radionuclide Therapy
https://www.readbyqxmd.com/read/28291004/-18-f-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-for-other-thyroid-cancers-medullary-anaplastic-lymphoma-and-so-forth
#5
Mine Araz, Derya Çayır
Positron emission tomography/computed tomography (PET/CT) with (18)F-fluorodeoxyglucose (FDG) is used in staging, restaging, and evaluation of therapy response in many cancers as well as differentiated thyroid carcinomas especially in non-iodine avid variants. Its potential in less frequent thyroid tumors like medullary, anaplastic thyroid cancers, thyroid lymphoma and metastatic tumors of the thyroid however, is not well established yet. The aim of this review is to provide an overview on the recent applications and indications of (18)F-FDG PET/CT in these tumors and to focus on the controversies in the clinical setting...
February 5, 2017: Molecular Imaging and Radionuclide Therapy
https://www.readbyqxmd.com/read/28290723/accuracy-of-18-f-fdg-pet-ct-to-detect-bone-marrow-clearance-in-patients-with-peripheral-t-cell-lymphoma-tissue-remains-the-issue
#6
Anthony Q Pham, Stephen M Broski, Thomas M Habermann, Dragan Jevremovic, Gregory A Wiseman, Andrew L Feldman, Matthew J Maurer, Kay M Ristow, Thomas E Witzig
Staging of peripheral T-cell non-Hodgkin lymphoma (PTCL) is determined by 18-F FDG PET scan and bone marrow biopsy. This study addressed the accuracy of PET at detecting bone marrow (BM) involvement at restaging in patients with known involvement pretreatment. We identified patients with biopsy proven BM PTCL at diagnosis and concomitant BM and PET at the end of therapy. Pre-treatment PET demonstrated 50% (8/16) had a false-negative PET scan of the BM. After induction, repeat biopsy revealed 62.5% (10/16) with BM involvement...
March 14, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/28287948/spectrum-of-ct-findings-in-thoracic-extranodal-non-hodgkin-lymphoma
#7
Mathew P Bligh, Joy N Borgaonkar, Steven C Burrell, David A MacDonald, Daria Manos
Non-Hodgkin lymphoma (NHL) frequently manifests in extranodal structures in the chest, often in the form of secondary involvement but occasionally as primary disease. Because staging and treatment are affected by the presence of extranodal disease at imaging, radiologists' interpretation and management of suspicious findings are critical to patient care. Unfortunately, owing to considerable imaging overlap with other diseases, primary extranodal lymphoma is difficult to diagnose with imaging alone. Radiologists should have a heightened degree of suspicion in patients at risk (including patients with immune compromise, autoimmune diseases, or a history of stem cell or solid organ transplant) or with particular imaging appearances (including the vertebral wraparound sign, nonresolving consolidation, an infiltrative soft-tissue mass, and lesions demonstrating vascular encasement without invasion)...
March 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/28270020/18f-fdg-pet-ct-and-extragastric-malt-lymphoma-role-of-ki-67-score-and-plasmacytic-differentiation
#8
Domenico Albano, Giovanni Bosio, Raffaele Giubbini, Francesco Bertagna
The detection rate of fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) in extragastric mucosa associated lymphoid tissue (MALT) lymphoma is under debate and the reason is not clear. Our aim was to investigate the metabolic behavior of extragastric MALT lymphoma and whether the histological features (Ki-67 index and plasmacytic differentiation, PD) might explain it. PET/CT images were analyzed visually and semi-quantitatively and compared with Ki-67 index and PD...
March 7, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/28264597/report-of-the-6th-international-workshop-on-pet-in-lymphoma
#9
Cristina Nanni, Anne Ségolène Cottereau, Egesta Lopci, Caroline Bodet-Milin, Monica Coronado, Barbara Pro, Wong Seog Kim, Judith Trotman, Sally Barrington, Ulrich Duhrsen, Thierry Vander Borght, Elena Zamagni, Françoise Kraeber-Bodéré, Christina Messiou, Alain Rahmouni, Irène Buvat, Marc Andre, Mark Hertzberg, Wim Oyen, Olivier Casasnovas, Stefano Luminari, Laurent Garderet, Françoise Montravers, Carsten Kobe, Regine Kluge, Annibale Versari, Emanuele Zucca, Philippe Moreau, Bruce Cheson, Corinne Haioun, Andrea Gallamini, Michel Meignan
Two hundred and ten nuclear medicine physicians, radiologists, and hematologists from 26 countries attended the 6th International Workshop on Positron Emission Tomography (PET) in Lymphoma and Myeloma held in Menton, France, in September 2016. The meeting was under the auspices of the European Lymphoma Institute (ELI), the European Association of Nuclear Medicine (EANM) the Lymphoma Study Association (LYSA), the Italian Foundation on Lymphoma (FIL) and the Carnot Institute for Lymphoma (CALYM). Forty scientific posters were presented...
March 7, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/28259031/follicular-lymphoma-transforming-into-diffuse-large-b-cell-lymphoma-in-spleen-simultaneous-appearance-of-both-on-18-f-fdg-pet-ct-and-histology
#10
William Makis, Anthony Ciarallo, Tina Petrogiannis-Haliotis, Arthur Rosenberg, Stephan Probst
Low grade lymphoma may transform into a more aggressive lymphoma and this transformation is usually associated with a poor outcome. A 65year old man presented with two metabolically active splenic lesions on a staging [18F] fluoro-2-deoxy-d-glucose ((18)F-FDG) positron emission tomography/computed tomography (PET/CT). Histologic evaluation post splenectomy confirmed the presence of two clonally related lymphomas: a follicular lymphoma (FL) and a diffuse large B-cell lymphoma (DLBCL). Molecular genetic studies confirmed that the DLBCL lesions arose from a pre-existing FL...
February 21, 2017: Clinical Imaging
https://www.readbyqxmd.com/read/28251914/rituximab-exposure-is-influenced-by-baseline-metabolic-tumor-volume-and-predicts-outcome-of-dlbcl-patients-a-lysa-study
#11
Mira Tout, Olivier Casasnovas, Michel Meignan, Thierry Lamy, Franck Morschhauser, Gilles Salles, Emmanuel Gyan, Corinne Haioun, Mélanie Mercier, Pierre Feugier, Sami Boussetta, Gilles Paintaud, David Ternant, Guillaume Cartron
High variability in patient outcome after rituximab-based treatment is partly explained by rituximab concentrations, and pharmacokinetic variability could be influenced by tumor burden. We aimed at quantifying the influence of baseline total metabolic tumor volume (TMTV0) on rituximab pharmacokinetics and of TMTV0 and rituximab exposure on outcome in patients with diffuse large B-cell lymphoma (DLBCL). TMTV0 was measured by (18)F-FDG-PET/CT in 108 previously untreated DLBCL patients who received four 375 mg/m(2) rituximab infusions every 2 weeks in combination with chemotherapy in two prospective trials...
March 1, 2017: Blood
https://www.readbyqxmd.com/read/28250859/-18-f-fdg-pet-ct-for-the-diagnosis-of-malignant-and-infectious-complications-after-solid-organ-transplantation
#12
Nastassja Muller, Romain Kessler, Sophie Caillard, Eric Epailly, Fabrice Hubelé, Céline Heimburger, Izzie-Jacques Namer, Raoul Herbrecht, Cyrille Blondet, Alessio Imperiale
PURPOSE: Infection and malignancy represent two common complications after solid organ transplantation, which are often characterized by poorly specific clinical symptomatology. Herein, we have evaluated the role of (18)F-fluoro-2-deoxy-D-glucose (FDG) positron emission tomography/computed tomography (PET/CT) in this clinical setting. METHODS: Fifty-eight consecutive patients who underwent FDG PET/CT after kidney, lung or heart transplantation were included in this retrospective analysis...
March 2017: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28245389/-clinical-value-of-18-f-fdg-pet-ct-for-patients-with-b-cell-lymphoma-associated-hemophagocytic-syndrome
#13
Chong-Yang Ding, Hong-Yu Liu, Zhe Guo, Yang-Yang Li, Wen-Ping Yang, Tian-Nv Li
OBJECTIVE: To investigate the clinical value of (18)F-FDG PET/CT for patients with B cell lymphoma-associated hemophagocytic syndrome. METHODS: The clinical characteristics, laboratory parameters and (18)F-FDG PET/CT data of 23 newly diagnosed patients sufferred from B cell lymphoma-associated hemophagocytic syndrome were retrospectively analyzed. The correlation between PET and laboratory parameters were determined using Spearman correlation test. The prognostic factors were analyzed by the Kaplan-Meier method...
February 2017: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/28243002/successful-staging-of-synchronous-gastric-cancer-and-diffuse-large-b-cell-lymphoma-dlbcl-using-f-18-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-fdg-pet-ct-based-on-distinctive-levels-of-metabolic-activity-between-the-two-malignancies
#14
Hossein Mehdikhani, Sherif Heiba
No abstract text is available yet for this article.
January 2017: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/28242998/18f-fdg-pet-ct-mri-fusion-images-showing-cranial-and-peripheral-nerve-involvement-in-neurolymphomatosis
#15
Ana Carolina Trevisan, Fernanda Borges Ribeiro, Emerson Nobuyuki Itikawa, Leonardo Santos Alexandre, Felipe Arriva Pitella, Antonio Carlos Santos, Belinda Pinto Simões, Lauro Wichert-Ana
We report a 56-year-old female patient with non-Hodgkin's diffuse large B cell lymphoma (NHL) who, on magnetic resonance imaging (MRI) with a T1 weighted and gadolinium-enhanced imaging, was found to have thickening and infiltration in 75% of peripheral nerves of the patient and enlargements of cranial nerves, possibly related to lymphomatous infiltration. Subsequent positron emission tomography/computed tomography (PET/CT) using (18)F-labeled 2-deoxy-2-fluoro-d-glucose ((18)F-FDG) showed widespread active involvement of the cervical plexus, bilateral peripheral nerves, right femoral nerve, the parasellar region of the skull, and marked hypermetabolism in the left trigeminal ganglia...
January 2017: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/28242988/-18-f-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-scan-in-an-unusual-case-of-lymphoma-with-secondary-involvement-of-uterine-cervix-presenting-as-a-pathological-fracture
#16
Arun Sasikumar, Ajith Joy, M R A Pillai, Boben Thomas
A 48-year-old female presented with a pathological fracture of the right femur. (99m)Tc methylene diphosphonate bone scan revealed multiple areas of increased osteoblastic activity consistent with metastatic disease. Serum electrophoresis revealed monoclonal gammopathy. (18)F-fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) scan revealed metabolically active lesions in bulky uterine cervix and osteolytic skeletal lesions. Unusual pattern of FDG uptake in uterine cervix and osteolytic skeletal lesions warranted a biopsy of the uterine cervix which revealed diffuse large B-cell lymphoma...
January 2017: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/28242986/mixed-phenotypic-acute-leukemia-mixed-myeloid-b-cell-with-myeloid-sarcoma-of-the-thyroid-gland-a-rare-entity-with-rarer-asssociation-detected-on-fdg-pet-ct
#17
Gaurav Khanna, Nishikant Avinash Damle, Shipra Agarwal, Maitrayee Roy, Deepali Jain, Soumyaranjan Mallick, Shamim Ahmed, Madhavi Tripathi, Ajay Gogia
Mixed phenotypic acute leukemia (MPAL) is a rare clinical entity. MPAL associated with myeloidsarcoma (MS) is still rarer with only three cases mentioned in English literature. MS has been described in myriads of location, most commonly in skin, gums and lymph nodes. Although theoritically possible, it is very rare to find MS involving the thyroid gland. The diagnosis of MS can be elusive, very often masquerades and mislabeled as lymphoma. A high index of clinical suspicion coupled with PET/CT findings along with morphological clues and thorough peripheral blood, and bone marrow evaluation is mandatory for arriving at the definitive diagnosis...
January 2017: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/28240665/fdg-pet-to-diagnose-neurolymphomatosis-in-a-case-of-triple-hit-b-cell-lymphoma
#18
Caroline Bund, Céline Heimburger, Philippe Trensz, Cécile Fohrer, Stéphane Kremer, Izzie-Jacques Namer
A 46-year-old man with stage IV triple-hit B-cell lymphoma diagnosed in February 2016 was treated with chemotherapy. He was followed classically with FDG PET/CT, which assessed the complete metabolic response in June 2016. In July 2016, he had autologous stem cell transplantation. Two months later, he underwent an FDG PET/CT for revaluation. It showed intense FDG uptake in the medullary canal from cervical 4 to thoracic 4, bilateral cervical 7 to thoracic 8, and right thoracic 9 to 12 nerve roots, leading to the diagnosis of neurolymphomatosis...
February 24, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28229191/-18-f-fdg-pet-ct-imaging-versus-bone-marrow-biopsy-in-pediatric-hodgkin-s-lymphoma-a-quantitative-assessment-of-marrow-uptake-and-novel-insights-into-clinical-implications-of-marrow-involvement
#19
Aamna Hassan, Maimoona Siddique, Humayun Bashir, Saima Riaz, Rabia Wali, Asma Mahreen, M Khalid Nawaz
OBJECTIVE: To evaluate whether positron emission tomography/computed tomography using fluorine-18 fluoro-deoxyglucose ((18)F-FDG PET-CT) predicts bone marrow involvement (BMI) in pediatric Hodgkin's lymphoma (pHL) with sufficient accuracy to supplant routine staging bone marrow biopsy (BMB), and to assess the clinical importance of marrow disease by comparing the prognosis of stage IV HL with BMI versus that without BMI. METHODS: Data were retrospectively analyzed for all cases of pHL between July 2010 and June 2015 referred for staging (18)F-FDG PET-CT scan and BMB...
February 22, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28225435/the-role-of-18f-fdg-pet-ct-in-staging-and-restaging-primary-bone-lymphoma
#20
Yiyan Liu
PURPOSE: Primary bone lymphoma (PBL) is one of the rarest primary bone malignancies. Very limited data are available on the role of fluorine-18-fluorodeoxyglucose (F-FDG) PET/CT in PBL. PATIENTS AND METHODS: Overall, 16 relevant patients had F-FDG PET/CT for staging or staging/restaging PBL. The cases with extraskeletal lesions such as lymphadenopathy or with osseous involvements in disseminated lymphoma were excluded on the basis of the definition of PBL. F-FDG PET/CT findings were correlated to pathologic and/or anatomic image information...
April 2017: Nuclear Medicine Communications
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