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Lymphoma FDG PET/CT

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https://www.readbyqxmd.com/read/29344718/combination-of-baseline-fdg-pet-ct-total-metabolic-tumour-volume-and-gene-expression-profile-have-a-robust-predictive-value-in-patients-with-diffuse-large-b-cell-lymphoma
#1
Mathieu Nessim Toledano, P Desbordes, A Banjar, I Gardin, P Vera, P Ruminy, F Jardin, H Tilly, S Becker
PURPOSE: This study evaluated the predictive significance of total metabolic tumour volume (TMTV) measured on baseline FDG PET/CT and its value in addition to gene expression profiling using a new method of gene analysis (rapid reverse transcriptase multiplex ligation-dependent probe amplification assay, RT-MLPA) in patients with diffuse large B-cell lymphoma treated with R-CHOP or R-CHOP-like chemotherapies. METHODS: The analysis included 114 patients. TMTV was measured using a 41% SUVmax threshold and tumours were classified into GCB or ABC subtypes according to the RT-MLPA assay...
January 17, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29344120/interim-18f-fdg-pet-ct-improves-the-prognostic-value-of-s-ipi-r-ipi-and-nccn-ipi-in-patients-with-diffuse-large-b-cell-lymphoma
#2
Maoqing Jiang, Ping Chen, Xinzhong Ruan, Xianwang Ye, Yuning Pan, Jie Zhang, Qiuli Huang, Wenlan Zhou, Hubing Wu, Quanshi Wang
The current study aimed to explore whether the efficiency of the standard International Prognostic Index (S-IPI), revised-IPI (R-IPI) and enhanced-IPI (NCCN-IPI) in evaluating the prognosis of patients with diffuse large B-cell lymphoma (DLBCL) may be improved by interim 18F-FDG PET/CT. A total of 185 patients with newly diagnosed DLBCL were enrolled in the current study. All patients underwent interim PET/CT following the 4th cycle of chemotherapy. Patients were divided into different risk groups using S-IPI, R-IPI and NCCN-IPI and further subdivided into risk groups using interim PET/CT...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29341235/concomitant-cutaneous-squamous-cell-carcinoma-and-cll-in-a-patient-the-utility-of-18-f-fdg-pet-ct-in-differentiation-of-nodal-metastasis
#3
Kerem Ozturk, Celalettin Ustun, Sobia Khaja, Faqian Li, Matthew Rischall, Zuzan Cayci
INTRODUCTION: Head and neck cutaneous squamous cell carcinoma (cSCC) often presents with cervical lymph node metastases. Lymphoma is the second most common malignancy in the cervical region, however, it is rarely synchronous with head and neck cSCC. METHODS: We describe the unusual presentation of a patient with small lymphocytic lymphoma/chronic lymphocytic leukemia (SLL/CLL) and metastatic head and neck cSCC on 18-fluorodeoxyglucose positron emission tomography (18 F-FDG PET/CT)...
January 17, 2018: American Journal of Hematology
https://www.readbyqxmd.com/read/29333861/intra-and-inter-observer-agreement-in-the-visual-interpretation-of-interim-18f-fdg-pet-ct-in-malignant-lymphoma-influence-of-clinical-information
#4
Maya Kato Arimoto, Yuji Nakamoto, Tatsuya Higashi, Takayoshi Ishimori, Mana Ishibashi, Kaori Togashi
Background Interim PET/CT is widely performed in lymphoma patients in clinical practice and clinical trials. Visual assessment using a 5-point scale is proposed for PET/CT interpretation, but intra- and inter-observer variation is not fully investigated. Purpose To investigate intra- and inter-observer variations in the reporting of interim positron emission tomography/computed tomography (PET/CT) in lymphoma patients, and the influence of clinical information on the interpretation. Material and Methods Three expert readers from different institutions interpreted interim PET/CT images of 42 consecutive patients with malignant lymphoma twice, with and without clinical information...
January 1, 2018: Acta Radiologica
https://www.readbyqxmd.com/read/29322833/primary-genitourinary-lymphoma-on-fdg-pet
#5
Nikita Naik, Michael Lin, Peter Lin
Primary extra nodal lymphomatous involvement of the genitourinary tract is rare and secondary extra-nodal involvement in disseminated disease occurs more frequently. Imaging of metabolic activity with 2-[fluorine-18] fluoro-2-deoxy-d-glucose (FDG) used in positron emission tomography (PET) facilitates the identification of these extra-nodal sites of disease, particularly in the absence of structural lesions on conventional imaging modalities. Primary extra-nodal lymphoma affecting the genitourinary system is often caused by high-grade Non-Hodgkin's Lymphoma (NHL) with the most common subtype being Diffuse Large B-Cell Lymphoma (DLBCL)...
January 11, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29288275/correction-to-diagnostic-and-prognostic-value-of-baseline-fdg-pet-ct-skeletal-textural-features-in-diffuse-large-b-cell-lymphoma
#6
Nicolas Aide, Marjolaine Talbot, Christophe Fruchart, Gandhi Damaj, Charline Lasnon
The formulae for Dice and Jaccard indices used to assess volumes concordance should read as follows.
December 29, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29279943/assessment-of-alteration-in-liver-18f-fdg-uptake-due-to-steatosis-in-lymphoma-patients-and-its-impact-on-the-deauville-score
#7
Thibault Salomon, Catherine Nganoa, Anne-Claire Gac, Christophe Fruchart, Gandhi Damaj, Nicolas Aide, Charline Lasnon
AIM: Our aim was (1) to evaluate the prevalence of steatosis in lymphoma patients and its evolution during treatment; (2) to evaluate the impact of hepatic steatosis on 18F-FDG liver uptake; and (3) to study how hepatic steatosis affects the Deauville score (DS) for discriminating between responders and non-responders. METHODS: Over a 1-year period, 358 PET scans from 227 patients [122 diffuse large B cell lymphoma (DLBCL), 57 Hodgkin lymphoma (HL) and 48 Follicular lymphoma (FL)] referred for baseline (n = 143), interim (n = 79) and end-of-treatment (EoT, n = 136) PET scans were reviewed...
December 26, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29245926/prognostic-significance-of-total-metabolic-tumor-volume-on-18f-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-in-patients-with-diffuse-large-b-cell-lymphoma-receiving-rituximab-containing-chemotherapy
#8
Chin-Chuan Chang, Shih-Feng Cho, Ya-Wen Chuang, Chia-Yang Lin, Shu-Min Chang, Wen-Ling Hsu, Ying-Fong Huang
Purpose: The purpose of this study was to determine the prognostic significance of metabolic parameters on pre-treatment 18F-fluorodeoxyglucose positron emission tomography/ computed tomography (FDG PET/CT), in patients with diffuse large B-cell lymphoma (DLBCL) receiving rituximab-containing therapy. Materials and Methods: From September 2009 to December 2014, DLBCL patients who had received FDG PET/CT scans for staging were enrolled. The maximal standardized uptake value of tumor (SUVt) was recorded...
November 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/29242737/radiation-induced-giant-cell-granuloma-mimicking-relapsed-hodgkin-lymphoma-at-fdg-pet-ct
#9
Hugo J A Adams, John M H de Klerk, Josien C Regelink, Ben G F Heggelman, Stefan V Dubois, Thomas C Kwee
A 22-year-old woman was diagnosed with intermediate risk stage II Hodgkin lymphoma and treated with three cycles of adriamycin, bleomycin, vinblastine, and dacarbazine (ABVD) followed by involved-field radiation therapy. A complete metabolic remission was achieved after two cycles of ABVD, which was maintained until three years after completion of treatment. Follow-up FDG-PET/CT four years after completion of treatment, however, showed a new FDG-avid (Deauville score of 4) lesion in the right scapula, suggesting relapsed disease...
December 2017: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29242726/relationship-between-dual-time-point-fdg-pet-ct-and-clinical-prognostic-indexes-in-patients-with-high-grade-lymphoma-a-pilot-study
#10
Do Hyoung Lim, Jai Hyuen Lee
Purpose: This study investigated the correlative relationship between metabolic parameters estimated from dual time point 2-deoxy-2-[18F] fluoro-D-glucose (18F-FDG) positron emission tomography/computerized tomography (PET/CT) and the clinical tools predicting the outcome of a lymphoma. We also measured metabolic and volumetric alterations between early and delayed 18F-FDG PET/CT in patients with high grade lymphoma (HGL). Methods: The samples were 122 lymph nodes and extralymphatic lesions from 26 patients diagnosed with HGL...
December 2017: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29236066/avid-18f-fdg-uptake-in-idiopathic-tumoral-calcinosis-mimicking-lymph-node-metastasis
#11
Jesper Strandberg, Helle D Zacho
Tumoral calcinosis is a benign condition characterized by periarticular calcified lesions that is frequently observed in patients with chronic renal failure. Tumoral calcinosis often presents with subcutaneous masses and joint swelling. We present a case of tumoral calcinosis with dramatically increased 18F-fluoro-2-deoxy-d-glucose (18F-FDG) uptake on positron emission tomography/computed tomography (PET/CT) that mimicked lymphoma or lymph node metastases.
December 13, 2017: Diagnostics
https://www.readbyqxmd.com/read/29215415/epstein-barr-virus-associated-hemophagocytic-lymphohistiocytosis-mimicking-lymphoma-on-fdg-pet-ct
#12
Qingqing Pan, Yaping Luo, Huanwen Wu, Yanru Ma, Fang Li
A 15-year-old boy with fever, pancytopenia, and hepatosplenomegaly was diagnosed as hemophagocytic lymphohistiocytosis (HLH). F-FDG PET/CT showed hypermetabolic foci in the liver, spleen, and bone marrow, as well as multiple FDG-avid lymph nodes, which were highly suggestive of lymphoma. Specimens from splenectomy depicted a large number of macrophages/histiocytes with hemophagocytosis of erythrocytes, without evidence of malignancy. Considering increased Epstein-Barr virus (EBV) DNA in peripheral blood and positive staining for EBV-encoded RNA in the spleen, EBV-associated HLH was confirmed...
December 5, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29214417/diagnostic-and-prognostic-value-of-baseline-fdg-pet-ct-skeletal-textural-features-in-diffuse-large-b-cell-lymphoma
#13
Nicolas Aide, Marjolaine Talbot, Christophe Fruchart, Gandhi Damaj, Charline Lasnon
PURPOSE: Our purpose was to evaluate the diagnostic and prognostic value of skeletal textural features (TFs) on baseline FDG PET in diffuse large B cell lymphoma (DLBCL) patients. METHODS: Eighty-two patients with DLBCL who underwent a bone marrow biopsy (BMB) and a PET scan between December 2008 and December 2015 were included. Two readers blinded to the BMB results visually assessed PET images for bone marrow involvement (BMI) in consensus, and a third observer drew a volume of interest (VOI) encompassing the axial skeleton and the pelvis, which was used to assess skeletal TFs...
December 7, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29200675/neurolymphomatosis-a-surreal-presentation-of-lymphoma
#14
Shikha Khandelwal, Suvinay Saxena, Disha J Hansalia
Background: Neurolymphomatosis is a neurologic complication poorly recognized by neurologists and oncologists and presents usually several months after successful treatment of systemic lymphoma. Other disorders that must be differentiated from these entities include peripheral-nerve or nerve root compression and paraneoplastic neuropathy. Aim: To describe the unusual occurrence of neurolymphomatosis in a patient of B-cell lymphoma. Method: Diagnosis was made by demonstration of enhancement of nerve roots on Magnetic Resonance Imaging of the brachial, lumbosacral plexus, peripheral nerves or by increased hyper-metabolic activity along the course of affected nerves on fluorodeoxyglucose positron emission tomography (FDG-PET)...
July 2017: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/29199055/bone-marrow-involvement-in-malignant-lymphoma-evaluation-of-quantitative-pet-and-mri-biomarkers
#15
Ulrika Asenbaum, Richard Nolz, Georgios Karanikas, Julia Furtner, Ramona Woitek, Ingrid Simonitsch-Klupp, Markus Raderer, Marius E Mayerhoefer
RATIONALE AND OBJECTIVES: This study aimed to determine the diagnostic utility of standardized uptake values (SUV) and apparent diffusion coefficients (ADC) for assessment of focal and diffuse bone marrow involvement in patients with malignant lymphoma. MATERIALS AND METHODS: Sixty treatment-naive patients (28 males; mean age 51.2 ± 16.7 years) with histologically proven lymphoma, who underwent fludeoxyglucose (18F) positron emission tomography-computed tomography ([F18]-FDG-PET/CT) and whole-body diffusion-weighted imaging (WB-DWI) within 7 days, and also routine bone marrow biopsy, were included in this institutional review board-approved, retrospective study...
November 30, 2017: Academic Radiology
https://www.readbyqxmd.com/read/29195620/pet-ct-in-lymphoma-current-overview-and-future-directions
#16
REVIEW
Bruce D Cheson
Over the past several decades, PET has emerged as critical to accurate staging and restaging of lymphomas. Nonetheless, a number of critical issues regarding its optimal use remain. Whereas risk-adapted strategies appear to improve the outcome of patients with Hodgkin lymphoma, results are less convincing in non-Hodgkin lymphoma. Assessment of metabolic tumor volume before treatment may permit novel induction strategies. New drugs that may induce an immune response may result in a false-positive FDG/PET scan, mandating modifications of current criteria to consider tumor flare reactions...
January 2018: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/29195619/pet-ct-in-radiation-therapy-planning
#17
REVIEW
Lena Specht, Anne Kiil Berthelsen
Radiation therapy (RT) is an important component of the management of lymphoma patients. Most lymphomas are metabolically active and accumulate 18F-fluorodeoxyglucose (FDG). Positron emission tomography with computer tomography (PET/CT) imaging using FDG is used routinely in staging and treatment evaluation. FDG-PET/CT imaging is now also used routinely for contouring the target for RT, and has been shown to change the irradiated volume significantly compared with CT imaging alone. Modern advanced imaging techniques with image fusion and motion management in combination with modern highly conformal RT techniques have increased the precision of RT, and have made it possible to reduce dramatically the risks of long-term side effects of treatment while maintaining the high cure rates for these diseases...
January 2018: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/29195617/pet-ct-for-staging-past-present-and-future
#18
REVIEW
Tarec Christoffer El-Galaly, Lars Christian Gormsen, Martin Hutchings
Accurate and reproducible staging is crucial for management of malignant lymphomas. Disease stage influences treatment decisions more significantly than any other clinical information in most lymphoma subtypes, and contributes with important prognostic information on its own or as part of clinical prognostic scores. Information derived from medical imaging is the single most important determinant of disease stage, and the introduction PET/CT for lymphoma has led to substantial changes in the concept as well as practice of lymphoma staging...
January 2018: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/29195616/pet-ct-for-lymphoma-post-therapy-response-assessment-in-other-lymphomas-response-assessment-for-autologous-stem-cell-transplant-and-lymphoma-follow-up
#19
REVIEW
Shawn Karls, Hina Shah, Heather Jacene
FDG-PET/CT is an established first-line diagnostic imaging tool used in the staging of most lymphomas and for post-therapy response assessment in Hodgkin lymphoma (HL) and diffuse large B-cell lymphoma (DLBCL). Many of the subtypes of lymphoid neoplasms classified by the World Health Organization demonstrate significant FDG-avidity or uptake; however, many guidelines and Lugano classification do not recommend the use of FDG-PET/CT in assessing response to therapy for these non-HL, non-DLBCL subtypes as a first-line diagnostic tool...
January 2018: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/29195615/pet-ct-for-lymphoma-post-therapy-response-assessment-in-hodgkin-lymphoma-and-diffuse-large-b-cell-lymphoma
#20
REVIEW
Carsten Kobe, Markus Dietlein, Dirk Hellwig
Over the course of many decades, combined chemotherapy and radiotherapy adapted to the stage of disease have become the optimal and standard treatment for Hodgkin lymphoma (HL) and diffuse large B-cell lymphoma. Besides achieving optimized cure rates of the underlying disease, reduction of toxicity has become a major goal. Since the introduction of FDG-PET for the staging and restaging of patients with lymphoma, a high predictive value of F-18-FDG-PET in response assessment has been observed. Several PET-response-guided therapy regimens have already been established, and even more PET-adapted study designs are being tested in large study groups...
January 2018: Seminars in Nuclear Medicine
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