Marta Nugnes, Maurizio Baldassarre, Danilo Ribichini, Daniele Tedesco, Irene Capelli, Daniele Vetrano, Francesca Marchignoli, Lucia Brodosi, Enrico Pompili, Maria Letizia Petroni, Gaetano La Manna, Giulio Marchesini, Marina Naldi, Manuela Bartolini
Diabetic kidney disease (DKD) is a major cause of morbidity and mortality in individuals with type 2 diabetes mellitus (T2DM). The aim of this study was to investigate whether albumin structural alterations correlate with DKD severity and evaluate whether native and reduced albumin concentrations could complement the diagnosis of DKD. To this end, one hundred and seventeen T2DM patients without ( n = 42) and with ( n = 75) DKD (DKD I-III upon KDIGO classification) were evaluated; the total albumin concentration (tHA) was quantified by a bromocresol green assay, while structural alterations were profiled via liquid chromatography-high-resolution mass spectrometry (LC-HRMS)...
March 9, 2024: International Journal of Molecular Sciences