Jiansong Qi, Qingqing Li, Tianli Xin, Qixia Lu, Jinyi Lin, Yang Zhang, Haiting Luo, Feifei Zhang, Yanhong Xing, Wuyang Wang, Derong Cui, Mengmeng Wang
MCOLN1/TRPML1 is a nonselective cationic channel specifically localized to the late endosome and lysosome. With its property of mediating the release of several divalent cations such as Ca2+ , Zn2+ and Fe2+ from the lysosome to the cytosol, MCOLN1 plays a pivotal role in regulating a variety of cellular events including endocytosis, exocytosis, lysosomal biogenesis, lysosome reformation, and especially in Macroautophagy/autophagy. Autophagy is a highly conserved catabolic process that maintains cytoplasmic integrity by removing superfluous proteins and damaged organelles...
March 24, 2024: Autophagy