Read by QxMD icon Read


Ion Cristobal, Blanca Torrejón, Manuel Pedregal, Federico G Rojo, Jesús García-Foncillas
Dear Editor, We have read with great interest the recent published manuscript by Caiazza et al. (2016), which provides novel exciting findings about the potential therapeutic value of enzalutamide in patients with androgen receptor (AR)-positive triple negative breast cancer (TNBC). Some previous studies have shown promising antitumor effects of this drug in breast tumors. Thus, enzalutamide-mediated AR inhibition has been reported to reduce proliferation, anchorage-independent growth, migration, and invasion and increases apoptosis of TNBC cells in vitro and decrease viability of TNBC xenografts in vivo (Cochrane et al...
October 20, 2016: Endocrine-related Cancer
Haiting Zhao, Renjun Peng, Qing Liu, Dingyang Liu, Peng Du, Jian Yuan, Gang Peng, Yiwei Liao
H19, one of the first found cancer-associated long non-coding RNAs (lncRNAs), is involved in the development and progression of many types of tumors. An aberrant expression of H19 was observed in hepatocellular carcinoma, cervical cancer, breast cancer, ovarian cancer, and colorectal cancer. However, the exact effects and molecular mechanisms of H19 in glioma progression are still unknown up to now. In this study, we investigated the role of H19 in human glioma cell lines and clinical tumor samples in order to determine the function of this molecule...
September 28, 2016: Archives of Biochemistry and Biophysics
Xinhua Cao, Na Zhao, Ruohan Li, Haiting Lv, Zongwen Zhang, Aiping Gao, Tao Yi
A series of bi-cholesteryl based gelators containing different central linker atoms C, N, and O (abbreviation as GC, GN and GO, respecctively) have been designed and sysnthsized. The self-assembly processes of these gelators were investigated via gelation test, field emission scanning electron microscopy, field emission transmission electron microscope, UV-vis absorption and IR spectra, XRD, rheology and contacting angle experiments. The gelation ability, self-assembly morphology, rheological and surface wettability properties of these gelators strongly depend on the central linker atom of the gelator molecule...
September 29, 2016: Chemistry, An Asian Journal
Zhonghua Zhao, Xi Chen, Shengnan Hao, Rui Jia, Nana Wang, Shaoshui Chen, Mianli Li, Chuanxin Wang, Haiting Mao
Interleukin-35 (IL-35) is a recently discovered inhibitory cytokine, which is firstly discovered to be produced by regulatory T cells (Tregs) and proposed as a key effector molecule of Treg function. This study aims to analyze the correlation between IL-35 expression in tumor-infiltrating lymphocytes (TILs) of breast cancer tissue and patients' clinical characteristics. Plasma IL-35 was also determined in 60 patients with breast invasive ductal carcinoma (IDC) and 30 healthy women by enzyme-linked immunosorbent assay...
September 24, 2016: Cytokine
Sathish Paulraj Gundupalli, Subrata Hait, Atul Thakur
A crucial prerequisite for recycling forming an integral part of municipal solid waste (MSW) management is sorting of useful materials from source-separated MSW. Researchers have been exploring automated sorting techniques to improve the overall efficiency of recycling process. This paper reviews recent advances in physical processes, sensors, and actuators used as well as control and autonomy related issues in the area of automated sorting and recycling of source-separated MSW. We believe that this paper will provide a comprehensive overview of the state of the art and will help future system designers in the area...
September 20, 2016: Waste Management
Haiting Zhang, Yating Zhang, Xiaoxian Song, Yu Yu, Mingxuan Cao, Yongli Che, Jianlong Wang, Junbo Yang, Haitao Dai, Guizhong Zhang, Jianquan Yao
Here, vertical field effect phototransistors (VFEPTs) based on lead selenide colloidal quantum dots (PbSe CQDs) for infrared photo detection were investigated, using Au/Ag nanowires as the source transparent electrode. VFEPTs have the advantage of easy fabrication of ultrashort channel length devices, as the channel length is simply determined here by the PbSe CQDs active layer's thickness (260 nm). In ultrashort channels, photo-excited carriers quickly (in nanoseconds) transfer to the drain. As soon as a hole (electron) reaches the drain, a hole (electron) is replenished from the source...
October 21, 2016: Nanotechnology
Xiaoxian Song, Yating Zhang, Haiting Zhang, Yu Yu, Mingxuan Cao, Yongli Che, Jianlong Wang, Haitao Dai, Junbo Yang, Xin Ding, Jianquan Yao
Most lateral PbSe quantum dot field effect transistors (QD FETs) show a low on current/off current (I on/I off) ratio in charge transport measurements. A new strategy to provide generally better performance is to design PbSe QD FETs with vertical architecture, in which the structure parameters can be tuned flexibly. Here, we fabricated a novel room-temperature operated vertical quantum dot field effect transistor with a channel of 580 nm, where self-assembled Au/Ag nanowires served as source transparent electrodes and PbSe quantum dots as active channels...
October 7, 2016: Nanotechnology
Feiby L Nassan, Brent A Coull, Niels E Skakkebaek, Michelle A Williams, Ramace Dadd, Lidia Mínguez-Alarcón, Stephen A Krawetz, Elizabeth J Hait, Joshua R Korzenik, Alan C Moss, Jennifer B Ford, Russ Hauser
BACKGROUND: Phthalates are widely used chemicals with ubiquitous exposure. Dibutyl-phthalate (DBP), a male reproductive toxicant in animals, is understudied in humans. Some mesalamine medications used to treat inflammatory bowel disease (IBD) have DBP in their coating, whereas other mesalamine formulations do not. OBJECTIVES: Taking advantage of differences in mesalamine formulations, we investigated whether high-DBP exposure from mesalamine medications was associated with decreased semen parameters...
October 2016: Environment International
Jian Zhang, Bo Gao, Haiting Chai, Zhiqiang Ma, Guifu Yang
BACKGROUND: DNA-binding proteins (DBPs) play fundamental roles in many biological processes. Therefore, the developing of effective computational tools for identifying DBPs is becoming highly desirable. RESULTS: In this study, we proposed an accurate method for the prediction of DBPs. Firstly, we focused on the challenge of improving DBP prediction accuracy with information solely from the sequence. Secondly, we used multiple informative features to encode the protein...
2016: BMC Bioinformatics
Danielle A Stamm, Elizabeth Hait, Heather J Litman, Paul D Mitchell, Christopher Duggan
OBJECTIVES: The aim of the present study was to describe the prevalence and clinical features of gastrointestinal (GI) eosinophilic inflammation among pediatric patients with intestinal failure (IF). METHODS: Medical records of all patients studied in our institution's IF program who underwent GI endoscopy over a 15-year period were reviewed, and clinical, pathologic, nutrition, and laboratory data collected. RESULTS: One hundred five patients underwent 208 GI endoscopic procedures with biopsy...
September 2016: Journal of Pediatric Gastroenterology and Nutrition
Jianlong Wang, Yating Zhang, Mingxuan Cao, Xiaoxian Song, Yongli Che, Haiting Zhang, Heng Zhang, Jianquan Yao
The resonance characteristics of platinum-scatter-based random lasers from dye-doped polymer-dispersed liquid crystals (DDPDLCs) in capillary tubes were researched for the first time, to the best of our knowledge. After adding platinum nanoparticles (Pt NPs) into the liquid crystal mixtures, the emission spectra of DDPDLCs revealed a lower lasing threshold in comparison with those of DDPDLCs without Pt NPs due to light scattering of liquid crystal droplets and the local field enhancement around Pt NPs. Furthermore, the full width at half-maximum (FWHM) and the lasing threshold were determined by the doping density of the Pt NPs...
July 20, 2016: Applied Optics
Masayuki Nagahashi, Kizuki Yuza, Yuki Hirose, Masato Nakajima, Rajesh Ramanathan, Nitai C Hait, Phillip B Hylemon, Huiping Zhou, Kazuaki Takabe, Toshifumi Wakai
Based on research carried out over the last decade, it has become increasingly evident that bile acids act not only as detergents, but also as important signaling molecules that exert various biological effects via activation of specific nuclear receptors and cell signaling pathways. Bile acids also regulate the expression of numerous genes encoding enzymes and proteins involved in the synthesis and metabolism of bile acids, glucose, fatty acids, and lipoproteins, as well as energy metabolism. Receptors activated by bile acids include, farnesoid X receptor α, pregnane X receptor, vitamin D receptor, and G protein-coupled receptors, TGR5, muscarinic receptor 2, and sphingosine-1-phosphate receptor (S1PR)2...
September 2016: Journal of Lipid Research
Guoliang Shi, Gang Chen, Guirong Liu, Haiting Wang, Yingze Tian, Yinchang Feng
Modeled results are very important for environmental management. Unreasonable modeled result can lead to wrong strategy for air pollution management. In this work, an improved physically constrained source apportionment (PCSA) technology known as Multilinear Engine 2-species ratios (ME2-SR) was developed to the 11-h daytime and nighttime fine ambient particulate matter in urban area. Firstly, synthetic studies were carried out to explore the effectiveness of ME2-SR. The estimated source contributions were compared with the true values...
October 1, 2016: Journal of Environmental Management
Xiaodong Chen, Haiting Wang, Zhaohui Shi, Xiaoyuan Li, Boyi Shan, Tao Xue, Li Qiao, Fuquan Chen
OBJECTIVE: To investigate the long term clinical effect of budesonide treatment in middle meatus for chronic rhinosinusitis(CRS) following endoscopic sinus surgery (ESS). METHOD: A total number of 53 patients with CRS received ESS were divided into two groups according to budesonide treatment: budesonide-treated group with 21 cases (39.6%) and control group with 32 cases (60.4%). Gelatin sponges soaked with 1 ml budesonide suspension were put in middle meatus in budesonide-treated group, while only gelatin sponges were put in middle meatus in control group...
February 2016: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
Zhong Zheng, Chengjun Yang, Ruofeng Yin, Jinxi Jiang, Haiting He, Xinxin Wang, Mujie Kan, Yechen Xiao
The canine metabolic diseases, such as obesity and diabetes, have become a worldwide problem. Fibroblast growth factor 21 (FGF21) is a potent regulator which has many biological functions relative to metabolism regulation. It suggests that FGF21 plays important roles in regulating canine metabolic diseases. To acquire the recombinant canine FGF21 (rcFGF21) in Escherichia coli, the recombinant bacteria were induced by 0.5 mM IPTG for 16 hours at 16 °C, and the rcFGF21 protein was purified by Ni-NTA. 8 mg rcFGF21 was acquired from one liter bacteria...
2016: Protein and Peptide Letters
Honghai Zhang, Haiting Zhao, Xiaoxuan Yang, Qingsheng Xue, Joseph F Cotten, Hua-Jun Feng
OBJECTIVE: The DBA/1 mouse is a relevant animal model of sudden unexpected death in epilepsy (SUDEP), as it exhibits seizure-induced respiratory arrest (S-IRA) evoked by acoustic stimulation, followed by cardiac arrhythmia and death. Defects in serotonergic neurotransmission may contribute to S-IRA. The tryptophan hydroxylase-2 (TPH2) enzyme converts L-tryptophan to 5-hydroxytryptophan (5-HTP), a precursor for central nervous system (CNS) serotonin (5-HT) synthesis; and DBA/1 mice have a polymorphism that decreases TPH2 activity...
August 2016: Epilepsia
Diptarka Hait, Tianyu Zhu, David P McMahon, Troy Van Voorhis
Organic molecules with charge-transfer (CT) excited states are widely used in industry and are especially attractive as candidates for fabrication of energy efficient OLEDs, as they can harvest energy from nonradiative triplets by means of thermally activated delayed fluorescence (TADF). It is therefore useful to have computational protocols for accurate estimation of their electronic spectra in order to screen candidate molecules for OLED applications. However, it is difficult to predict the photophysical properties of TADF molecules with LR-TDDFT, as semilocal LR-TDDFT is incapable of accurately modeling CT states...
July 12, 2016: Journal of Chemical Theory and Computation
Hua Mao, Peizhu Su, Wendan Qiu, Liyun Huang, Haiting Yu, Yan Wang
AIM: Differentiation between Crohns disease (CD) and intestinal tuberculosis (ITB) continues to be difficult. The present study investigated the collagen fibre characteristics of CD and ITB using Masson's Trichrome staining and second harmonic generation imaging (SHG) and two-photon excited fluorescence (TPEF) imaging with the aim of distinguishing between them. METHOD: The characteristics of collagen fibres in intestinal specimens from patients with CD, ITB and healthy controls were compared using Masson's Trichrome staining, SHI and TPEF imaging...
May 27, 2016: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
Mingxuan Cao, Yating Zhang, Xiaoxian Song, Yongli Che, Haiting Zhang, Chao Yan, Haitao Dai, Guang Liu, Guizhong Zhang, Jianquan Yao
Quantum dot-doped polymer-dispersed liquid crystals (QD-PDLCs) were prepared by photoinitiated polymerization and sealed in capillary tubes. The concentration of QDs in the PDLC was 1 wt%. Amplified spontaneous emission (ASE) of the quantum dot-doped polymer-dispersed liquid crystals was observed with 532 nm wavelength laser excitation. The threshold for ASE was 6 mJ cm(-2), which is much lower than that for homogeneous quantum dot-doped polymer (25 mJ cm(-2)). The threshold for ASE was dramatically enhanced when the working temperature exceeded the clearing point of the liquid crystal; this result demonstrates that multi-scattering caused by the liquid crystals effectively improved the path length or dwell time of light in the gain region, which played a key role in decreasing the threshold for ASE...
July 1, 2016: Nanotechnology
William N Hait, Peter F Lebowitz
Malignant diseases develop slowly over time and are often preceded by identifiable premalignancies. As malignancy progresses, so does genomic complexity and the ability of cancers to evade most therapeutic interventions. Accordingly, with some notable exceptions, a relatively low percentage of advanced cancers are effectively treated and even fewer are cured. Despite this appreciation, much less attention has been paid to intercepting the disease process compared with that of treating well-established and refractory disease...
August 2016: Cancer Prevention Research
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"