keyword
MENU ▼
Read by QxMD icon Read
search

Hait

keyword
https://www.readbyqxmd.com/read/28722510/bnip3l-dependent-mitophagy-accounts-for-mitochondrial-clearance-during-three-factors-induced-somatic-cell-reprogramming
#1
Ge Xiang, Liang Yang, Qi Long, Keshi Chen, Haite Tang, Yi Wu, Zihuang Liu, Yanshuang Zhou, Juntao Qi, Lingjun Zheng, Wenbo Liu, Zhongfu Ying, Weimin Fan, Hongyan Shi, Hongmei Li, Xiaobing Lin, Mi Gao, Jinglei Liu, Feixiang Bao, Linpeng Li, Lifan Duan, Min Li, Xingguo Liu
Induced pluripotent stem cells (iPSCs) have less and immature mitochondria than somatic cells and mainly rely on glycolysis for energy source. During somatic cell reprogramming, somatic mitochondria and other organelles get remodeled. However, events of organelle remodeling and interaction during somatic cell reprogramming have not been extensively explored. We show that both SKP/SKO (Sox2, Klf4, Pou5f1/Oct4) and SKPM/SKOM (SKP/SKO plus Myc/c-Myc) reprogramming lead to decreased mitochondrial mass but with different kinetics and by divergent pathways...
July 19, 2017: Autophagy
https://www.readbyqxmd.com/read/28719898/role-of-mir-155-signal-pathway-in-regulating-podocyte-injury-induced-by-tgf-%C3%AE-1
#2
Xu Lin, Xintng Zhen, Haiting Huang, Haohao Wu, Yanwu You, Pengwei Guo, Xiangjun Gu, Fafen Yang
BACKGROUND/AIMS: Transforming growth factor beta 1 (TGF-β1) plays a critical role in the pathogenesis of glomerulosclerosis. The purpose of this study was to examine the effects of inhibition of miR-155 on podocyte injury induced by TGF-β1 and to determine further molecular mediators involved in the effects of miR-155. METHODS: Conditionally immortalized podocytes were cultured in vitro and they were divided into four groups: control; TGF-β1 treatment; TGF-β1 with miR-155 knockdown [using antisense oligonucleotides against miR-155 (ASO-miR-155)] and TGF-β1 with negative control antisense oligonucleotides (ASO-NC)...
July 18, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28718285/strong-blue-emissive-supramolecular-self-assembly-system-based-on-naphthalimide-derivatives-and-its-ability-of-detection-and-removal-of-2-4-6-trinitrophenol
#3
Xinhua Cao, Na Zhao, Haiting Lv, Qianqian Ding, Aiping Gao, Qiangshan Jing, Tao Yi
Two simple and novel gelators (G-P with pyridine and G-B with benzene) with different C-4 substitution groups on naphthalimide derivative have been designed and characterized. Two gelators could form organogels in some solvents or mixed solvents. The self-assembly processes of G-P in mixed solvent of acetonitrile / H2O (1/1, v/v) and G-B in acetonitrile were studied by means of electron microscopy and spectroscopy. The organogel of G-P in mixed solvent of acetonitrile / H2O (1/1, v/v) formed intertwined fiber network, and its emission spectrum had obvious blue shift comparing with that of solution...
July 18, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28718008/the-effect-of-vitamin%C3%A2-d-and-calcium-supplementation-on-falls-in-older-adults-a%C3%A2-systematic-review-and-meta-analysis
#4
Haiting Wu, Qingjiang Pang
OBJECTIVES: A number of studies have hypothesized that vitamin D is a potential factor in the prevention of falls in the elderly; however, the effect of vitamin D is still inconsistent and not quantitative. We conducted this meta-analysis to assess the effect of vitamin D on falls among elderly individuals. METHODS: The PubMed and Cochrane Library databases were searched from the earliest possible year up to December 2016. Two authors working independently reviewed the trials, and odds ratios (ORs) were calculated using a fixed-effect or random-effect model by Review Manager 5...
July 17, 2017: Der Orthopäde
https://www.readbyqxmd.com/read/28713248/deep-brain-magnetic-stimulation-promotes-neurogenesis-and-restores-cholinergic-activity-in-a-transgenic-mouse-model-of-alzheimer-s-disease
#5
Junli Zhen, Yanjing Qian, Jian Fu, Ruijun Su, Haiting An, Wei Wang, Yan Zheng, Xiaomin Wang
Alzheimer's disease (AD) is characterized by progressive decline of memory and cognitive functions. Deep magnetic stimulation (DMS), a noninvasive and nonpharmacological brain stimulation, has been reported to alleviate stress-related cognitive impairment in neuropsychiatric disorders. Our previous study also discovered the preventive effect of DMS on cognitive decline in an AD mouse model. However, the underlying mechanism must be explored further. In this study, we investigated the effect of DMS on spatial learning and memory functions, neurogenesis in the dentate gyrus (DG), as well as expression and activity of the cholinergic system in a transgenic mouse model of AD (5XFAD)...
2017: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/28688393/a-hybrid-memory-kernel-approach-for-condensed-phase-non-adiabatic-dynamics
#6
Diptarka Hait, Michael G Mavros, Troy Van Voorhis
The spin-boson model is a simplified Hamiltonian often used to study non-adiabatic dynamics in large condensed phase systems, even though it has not been solved in a fully analytic fashion. Herein, we present an exact analytic expression for the dynamics of the spin-boson model in the infinitely slow-bath limit and generalize it to approximate dynamics for faster baths. We achieve the latter by developing a hybrid approach that combines the exact slow-bath result with the popular non-interacting blip approximation (NIBA) method to generate a memory kernel that is formally exact to second-order in the diabatic coupling but also contains higher-order contributions approximated from the second-order term alone...
July 7, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28672999/continuous-intrathecal-administration-of-liposomal-amphotericin-b-for-treatment-of-refractory-cryptococcus-neoformans-encephalitis-a-case-report
#7
Haiting Xie, Peng Luo, Zhongli Li, Rui Li, Haitao Sun, Duobin Wu
The aim of the present study was to investigate the treatment of refractory Cryptococcus neoformans encephalitis with continuous administration of liposomal amphotericin B (AmB). Liposomal AmB was administered to a 28-year-old male by intravenous injection, with daily increasing dosages up to 150 mg per day and combined use of fluconazole (0.4 g per day) and oral flucytosine tablets (1.5 g per day). Following 5 months of treatment, C. neoformans could still be detected in the ink stain of cerebrospinal fluid, but the patient could not tolerate a further increase in the dosage of liposomal AmB...
July 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28661265/medium-term-effects-of-dynesys-dynamic-stabilization-versus-posterior-lumbar-interbody-fusion-for-treatment-of-multisegmental-lumbar-degenerative-disease
#8
Haiting Wu, Qingjiang Pang, Guoqiang Jiang
Objective To compare the medium-term clinical and radiographic outcomes of Dynesys dynamic stabilization and posterior lumbar interbody fusion (PLIF) for treatment of multisegmental lumbar degenerative disease. Methods Fifty-seven patients with multisegmental lumbar degenerative disease underwent Dynesys stabilization (n = 26) or PLIF (n = 31) from December 2008 to February 2010. The mean follow-up period was 50.3 (range, 46-65) months. Clinical outcomes were evaluated using a visual analogue scale (VAS) and the Oswestry disability index (ODI)...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28605634/atomoxetine-a-norepinephrine-reuptake-inhibitor-reduces-seizure-induced-respiratory-arrest
#9
Honghai Zhang, Haiting Zhao, Hua-Jun Feng
Sudden unexpected death in epilepsy (SUDEP) is a devastating epilepsy complication, and no effective preventive strategies are currently available for this fatal disorder. Clinical and animal studies of SUDEP demonstrate that seizure-induced respiratory arrest (S-IRA) is the primary event leading to death after generalized seizures in many cases. Enhancing brain levels of serotonin reduces S-IRA in animal models relevant to SUDEP, including the DBA/1 mouse. Given that serotonin in the brain plays an important role in modulating respiration and arousal, these findings suggest that deficits in respiration and/or arousal may contribute to S-IRA...
June 9, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28583090/prediction-of-bioluminescent-proteins-by-using-sequence-derived-features-and-lineage-specific-scheme
#10
Jian Zhang, Haiting Chai, Guifu Yang, Zhiqiang Ma
BACKGROUND: Bioluminescent proteins (BLPs) widely exist in many living organisms. As BLPs are featured by the capability of emitting lights, they can be served as biomarkers and easily detected in biomedical research, such as gene expression analysis and signal transduction pathways. Therefore, accurate identification of BLPs is important for disease diagnosis and biomedical engineering. In this paper, we propose a novel accurate sequence-based method named PredBLP (Prediction of BioLuminescent Proteins) to predict BLPs...
June 5, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28514159/direct-observation-of-an-efficient-triplet-exciton-diffusion-process-in-a-platinum-containing-conjugated-polymer
#11
Lili Du, Wenjuan Xiong, Shun-Cheung Cheng, Haiting Shi, Wai Kin Chan, David Lee Phillips
We report the synthesis and characterization of a conjugated polymer incorporated with cyclometalated platinum complexes on the main chain. The polymer may serve as an efficient triplet sensitizer in light-harvesting systems. The photophysical properties of the polymer were studied by nanosecond and femtosecond time-resolved transient absorption spectroscopies. After excitation, an energy-transfer process from the thiophene units on the conjugated main chain to the singlet excited state of the Pt complex moieties occurred in less than 150 fs...
May 22, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28494873/a-chimeric-egfr-protein-reporter-mouse-reveals-egfr-localization-and-trafficking-in%C3%A2-vivo
#12
Yu-Ping Yang, Haiting Ma, Alina Starchenko, Won Jae Huh, Wei Li, F Edward Hickman, Qin Zhang, Jeffrey L Franklin, Douglas P Mortlock, Sabine Fuhrmann, Bruce D Carter, Rebecca A Ihrie, Robert J Coffey
EGF receptor (EGFR) is a critical signaling node throughout life. However, it has not been possible to directly visualize endogenous Egfr in mice. Using CRISPR/Cas9 genome editing, we appended a fluorescent reporter to the C terminus of the Egfr. Homozygous reporter mice appear normal and EGFR signaling is intact in vitro and in vivo. We detect distinct patterns of Egfr expression in progenitor and differentiated compartments in embryonic and adult mice. Systemic delivery of EGF or amphiregulin results in markedly different patterns of Egfr internalization and trafficking in hepatocytes...
May 9, 2017: Cell Reports
https://www.readbyqxmd.com/read/28489755/kennedy-disease-with-difficulty-in-differential-diagnosis-a-case-report
#13
Yating Chen, Peng Luo, Zhongli Li, Hengping Hu, Duobin Wu, Tingting Xu, Xingzuo Wang, Haiting Xie
RATIONALE: Kennedy disease (KD) is also known as spinal bulbar muscular dystrophy. As KD has similar symptoms with most neuromuscular diseases, so it is difficult to make a rapid diagnosis clinically. PATIENT CONCERNS: We report a case of a 43-year-old male with progressive limb proximal weakness without family history. Physical examination showed gynecomastia, erectile dysfunction, bilateral tendon reflex and quadriceps weakness, and tongue muscle atrophy. DIAGNOSES: Laboratory examination found increased creatine kinase, impaired glucose tolerance, and abnormal lactic acid values...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28463731/effect-of-oxidant-demand-on-the-release-and-degradation-of-microcystin-lr-from-microcystis-aeruginosa-during-oxidation
#14
Haiting Zhang, Yongbo Dan, Craig D Adams, Honglan Shi, Yinfa Ma, Todd Eichholz
In this research, the release and degradation of intracellular microcystin-LR (MC-LR) due to oxidation of Microcystis aeruginosa (M. aeruginosa) was examined kinetically. Brief exposure to free chlorine with no measureable oxidant exposure was demonstrated to be sufficient to induce rapid release of intracellular MC-LR from M. aeruginosa. Thus, in a water treatment plant, there is currently no level of prechlorination that can be assumed to be safe, since very low preoxidation prior to filtration and no measureable free chlorine residual may still observe the release and buildup of extracellular MC-LR...
April 24, 2017: Chemosphere
https://www.readbyqxmd.com/read/28448926/mass-spectra-features-of-biomass-burning-boiler-and-coal-burning-boiler-emitted-particles-by-single-particle-aerosol-mass-spectrometer
#15
Jiao Xu, Mei Li, Guoliang Shi, Haiting Wang, Xian Ma, Jianhui Wu, Xurong Shi, Yinchang Feng
In this study, single particle mass spectra signatures of both coal burning boiler and biomass burning boiler emitted particles were studied. Particle samples were suspended in clean Resuspension Chamber, and analyzed by ELPI and SPAMS simultaneously. The size distribution of BBB (biomass burning boiler sample) and CBB (coal burning boiler sample) are different, as BBB peaks at smaller size, and CBB peaks at larger size. Mass spectra signatures of two samples were studied by analyzing the average mass spectrum of each particle cluster extracted by ART-2a in different size ranges...
November 15, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28436109/efficiency-of-ustekinumab-in-crohn-s-disease-with-severe-psoriasiform-rash-induced-by-biotherapies-in-an-adolescent
#16
Valérie Bertrand, Abdelaziz El Haite, Delphine Carré
Ustekinumab is approved for the treatment of psoriasis in adolescents and for the treatment of moderate to severe Crohn's disease (CD) in adults, but data are lacking in pediatric CD. We report a case of severe psoriasis induced by biotherapies in an adolescent with CD that improved after switching to ustekinumab (90 mg at weeks 0, 2, and 4 and then every 8 weeks). The patient had not experienced CD relapse after 1 year of follow-up. Ustekinumab can be an alternative therapy for psoriasis induced by biotherapies when conventional treatment fails and can maintain remission of CD...
April 23, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28398753/droplet-motion-on-a-shape-gradient-surface
#17
Yanfen Zheng, Jiang Cheng, Cailong Zhou, Haiting Xing, Xiufang Wen, Pihui Pi, Shouping Xu
We demonstrate a facile method to induce water droplet motion on an wedge-shaped superhydrophobic copper surface combining with a poly(dimethylsiloxane) (PDMS) oil layer on it. The unbalanced interfacial tension from the shape gradient offers the actuating force. The superhydrophobicity critically eliminates the droplet contact line pinning and the slippery PDMS oil layer lubricates the droplet motion, which makes the droplet move easily. The maximum velocity and furthest position of droplet motion were recorded and found to be influenced by the gradient angle...
April 18, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28395714/-analysis-of-the-storage-time-in-paraformaldehyde-fixed-t-cells-and-their-subsets-in-kunming-mice
#18
Haiting Guo, Chao Hu, Pu Yan, Zhongyuan Li, Zhibao Chen
Objective To determine the expiration dates of CD3e(+)CD4(+) T and CD3e(+)CD8a(+) T lymphocytes of Kunming mice. Methods The sterile spleen and anticoagulant blood of Kunming mice were collected and used to prepare the single-cell suspensions. After CD3e, CD4 and CD8a of T cells were stained with fluorophore-conjugated monoclonal antibodies, the samples were fixed with paraformaldehyde (PFA) and stored at 4DegreesCelsius in dark followed by detection using three-color flow cytometry at several specific time points...
April 2017: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/28333635/blind-facial-image-quality-enhancement-using-non-rigid-semantic-patches
#19
Ester Hait, Guy Gilboa
We propose a new way to solve a very general blind inverse problem of multiple simultaneous degradations, such as blur, resolution reduction, noise, and contrast changes, without explicitly estimating the degradation. The proposed concept is based on combining semantic non-rigid patches, problem-specific high-quality prior data, and non-rigid registration tools. We show how a significant quality enhancement can be achieved, both visually and quantitatively, in the case of facial images. The method is demonstrated on the problem of cellular photography quality enhancement of dark facial images for different identities, expressions, and poses, and is compared with the state-of-the-art denoising, deblurring, super-resolution, and color-correction methods...
June 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28320945/three-dimensional-culture-system-identifies-a-new-mode-of-cetuximab-resistance-and-disease-relevant-genes-in-colorectal-cancer
#20
Cunxi Li, Bhuminder Singh, Ramona Graves-Deal, Haiting Ma, Alina Starchenko, William H Fry, Yuanyuan Lu, Yang Wang, Galina Bogatcheva, Mohseen P Khan, Ginger L Milne, Shilin Zhao, Gregory Daniel Ayers, Nenggan Li, Huaying Hu, Mary Kay Washington, Timothy J Yeatman, Oliver G McDonald, Qi Liu, Robert J Coffey
We previously reported that single cells from a human colorectal cancer (CRC) cell line (HCA-7) formed either hollow single-layered polarized cysts or solid spiky masses when plated in 3D in type-I collagen. To begin in-depth analyses into whether clonal cysts and spiky masses possessed divergent properties, individual colonies of each morphology were isolated and expanded. The lines thus derived faithfully retained their parental cystic and spiky morphologies and were termed CC (cystic) and SC (spiky), respectively...
April 4, 2017: Proceedings of the National Academy of Sciences of the United States of America
keyword
keyword
84993
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"