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https://www.readbyqxmd.com/read/29147072/paradoxical-association-of-postoperative-plasma-sphingosine-1-phosphate-with-breast-cancer-aggressiveness-and-chemotherapy
#1
Rajesh Ramanathan, Ali Raza, Jamie Sturgill, Debra Lyon, Jessica Young, Nitai C Hait, Kazuaki Takabe
Sphingosine-1-phosphate (S1P) is a bioactive lipid mediator that has been shown to serve an important regulatory function in breast cancer progression. This study analyzes plasma S1P levels in breast cancer patients undergoing adjuvant therapy as compared to healthy control volunteers. 452 plasma S1P samples among 158 breast cancer patients, along with 20 healthy control volunteers, were analyzed. Mean S1P levels did not significantly differ between cancer patients and controls. Smoking was associated with higher S1P levels in cancer patients...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/29141182/optogenetic-activation-of-5-ht-neurons-in-the-dorsal-raphe-suppresses-seizure-induced-respiratory-arrest-and-produces-anticonvulsant-effect-in-the-dba-1-mouse-sudep-model
#2
Honghai Zhang, Haiting Zhao, Chang Zeng, Christa Van Dort, Carl L Faingold, Norman E Taylor, Ken Solt, Hua-Jun Feng
Sudden unexpected death in epilepsy (SUDEP) is a devastating epilepsy complication. Seizure-induced respiratory arrest (S-IRA) occurs in many witnessed SUDEP patients and animal models as an initiating event leading to death. Thus, understanding the mechanisms underlying S-IRA will advance the development of preventive strategies against SUDEP. Serotonin (5-HT) is an important modulator for many vital functions, including respiration and arousal, and a deficiency of 5-HT signaling is strongly implicated in S-IRA in animal models, including the DBA/1 mouse...
November 12, 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/29124424/effects-of-gravel-sand-mulching-on-soil-bacterial-community-and-metabolic-capability-in-the-semi-arid-loess-plateau-china
#3
Haiting Hao, Xia Zhao, Yun Wang, Yubao Zhang, Zhongkui Xie, Zhihong Guo, Ruoyu Wang
Gravel and sand mulching is an indigenous technology used for the crop yield for at least 300 years in the loess area of northwest China; however, little is known about the changes of soil bacterial community and metabolic capability under the mulching. In this study, we investigated the soil microbial community structure and metabolic functional diversity during mulching using Illumina MiSeq sequencing and Biolog ECO method. Totally, 9417 OTUs were classified at 97% similarity level for soil samples after 0 (control), 4, 7, and 10 years of mulching...
November 9, 2017: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/29124106/gamma-rhythm-low-field-magnetic-stimulation-alleviates-neuropathologic-changes-and-rescues-memory-and-cognitive-impairments-in-a-mouse-model-of-alzheimer-s-disease
#4
Junli Zhen, Yanjing Qian, Xiechuan Weng, Wenting Su, Jianliang Zhang, Lihui Cai, Lin Dong, Haiting An, Ruijun Su, Jiang Wang, Yan Zheng, Xiaomin Wang
Introduction: The abnormal amyloid β (Aβ) accumulation and Aβ-related neural network dysfunction are considered central to the pathogenesis of Alzheimer's disease (AD) at the early stage. Deep-brain reachable low field magnetic stimulation (DMS), a novel noninvasive approach that was designed to intervene the network activity in brains, has been found to alleviate stress-related cognitive impairments. Methods: Amyloid precursor protein/presenilin-1 transgenic mice (5XFAD) were treated with DMS, and cognitive behavior and AD-like pathologic changes in the neurochemical and electrophysiological properties in 5XFAD mice were assessed...
November 2017: Alzheimer's & Dementia: Translational Research & Clinical Interventions
https://www.readbyqxmd.com/read/29078883/doxorubicin-effect-is-enhanced-by-sphingosine-1-phosphate-signaling-antagonist-in-breast-cancer
#5
Eriko Katsuta, Li Yan, Masayuki Nagahashi, Ali Raza, Jamie L Sturgill, Debra E Lyon, Omar M Rashid, Nitai C Hait, Kazuaki Takabe
BACKGROUND: Doxorubicin is one of the most commonly used chemotherapeutic drugs for breast cancer; however, its use is limited by drug resistance and side effects. We hypothesized that adding FTY720, a sphingosine-1-phosphate (S1P) receptor functional antagonist, to doxorubicin would potentiate its effects by suppression of drug-induced inflammation. MATERIALS AND METHODS: The Cancer Genome Atlas, Gene Expression Omnibus data sets, and National Cancer Institute-60 panel were used for gene expressions and gene set enrichment analysis...
November 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/29039557/microrna%C3%A2-663-suppresses-the-proliferation-and-invasion-of-colorectal-cancer-cells-by-directly-targeting-fscn1
#6
Shaojun Yu, Haiting Xie, Jingjing Zhang, Da Wang, Yongmao Song, Suzhan Zhang, Shu Zheng, Jian Wang
Colorectal cancer (CRC) is the most frequently diagnosed malignancy of the gastrointestinal tract. The dysregulation of microRNAs (miRNAs/miRs) has been reported in the majority of types of human cancer, and is correlated with tumorigenesis and tumor development. Abnormal expression of miR‑663 has been observed in various types of human cancer. However, little is known about its role in CRC. Therefore, the aim of the present study was to clarify the expression and potential role of miR‑663, and its underlying molecular mechanism in CRC...
December 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29033173/source-apportionment-for-fine-particulate-matter-in-a-chinese-city-using-an-improved-gas-constrained-method-and-comparison-with-multiple-receptor-models
#7
Guoliang Shi, Jiayuan Liu, Haiting Wang, Yingze Tian, Jie Wen, Xurong Shi, Yinchang Feng, Cesunica E Ivey, Armistead G Russell
PM2.5 is one of the most studied atmospheric pollutants due to its adverse impacts on human health and welfare and the environment. An improved model (the chemical mass balance gas constraint-Iteration: CMBGC-Iteration) is proposed and applied to identify source categories and estimate source contributions of PM2.5. The CMBGC-Iteration model uses the ratio of gases to PM as constraints and considers the uncertainties of source profiles and receptor datasets, which is crucial information for source apportionment...
October 12, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28980132/qualitative-and-quantitative-metals-liberation-assessment-for-characterization-of-various-waste-printed-circuit-boards-for-recycling
#8
Anshu Priya, Subrata Hait
Metals liberation and composition are decisive attributes in characterization of e-waste for metal recycling. Though end-of-life printed circuit board (PCB) is an integral part of e-waste as secondary resource reservoir, yet no standardized procedure exists for metals liberation and dissolution for its characterization. Thus, the paper aims at assessment of metals liberation upon comminution employing scanning electron microscopy with energy dispersive X-ray spectroscopy (SEM-EDS) followed by comparative assessment of the existing United States Environmental Protection Agency (USEPA) digestion procedures, viz...
October 4, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28978458/a-crossover-crossback-prospective-study-of-dibutyl-phthalate-exposure-from-mesalamine-medications-and-serum-reproductive-hormones-in-men
#9
Feiby L Nassan, Brent A Coull, Niels E Skakkebaek, Anna-Maria Andersson, Michelle A Williams, Lidia Mínguez-Alarcón, Stephen A Krawetz, Janet E Hall, Elizabeth J Hait, Joshua R Korzenik, Jennifer B Ford, Alan C Moss, Russ Hauser
BACKGROUND: Phthalates, such as dibutyl phthalate (DBP), are endocrine disruptors used in some medication coatings e.g., mesalamine to treat inflammatory bowel disease (IBD). OBJECTIVES: Taking advantage of different mesalamine formulations with/without DBP, we assessed whether DBP from mesalamine (>1000x background) altered serum hormones. METHODS: Men (N=73) with IBD participated in a crossover-crossback prospective study and provided up to 6 serum samples (2:baseline, 2:crossover, 2:crossback)...
October 1, 2017: Environmental Research
https://www.readbyqxmd.com/read/28951147/multi-material-classification-of-dry-recyclables-from-municipal-solid-waste-based-on-thermal-imaging
#10
Sathish Paulraj Gundupalli, Subrata Hait, Atul Thakur
There has been a significant rise in municipal solid waste (MSW) generation in the last few decades due to rapid urbanization and industrialization. Due to the lack of source segregation practice, a need for automated segregation of recyclables from MSW exists in the developing countries. This paper reports a thermal imaging based system for classifying useful recyclables from simulated MSW sample. Experimental results have demonstrated the possibility to use thermal imaging technique for classification and a robotic system for sorting of recyclables in a single process step...
September 23, 2017: Waste Management
https://www.readbyqxmd.com/read/28947538/phenotypic-and-functional-characterization-of-circulatory-splenic-and-hepatic-nk-cells-in-simian-immunodeficiency-virus-controlling-macaques
#11
Diego A Vargas-Inchaustegui, Sabrina Helmold Hait, Hye Kyung Chung, Jigna Narola, Tanya Hoang, Marjorie Robert-Guroff
NK cells are key components of the immune system because of their rapid response potential and their ability to mediate cytotoxic and immunomodulatory functions. Additionally, NK cells have recently been shown to persist for long periods in vivo and to have the capacity to establish immunologic memory. In the current study, we assessed the phenotype and function of circulatory and tissue-resident NK cells in a unique cohort of SIV-controlling rhesus macaques that maintained low to undetectable levels of viremia in the chronic phase of infection...
November 1, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28904348/transcriptome-profiling-of-genes-involved-in-induced-systemic-salt-tolerance-conferred-by-bacillus-amyloliquefaciens-fzb42-in-arabidopsis-thaliana
#12
Shaofang Liu, Haiting Hao, Xiang Lu, Xia Zhao, Yun Wang, Yubao Zhang, Zhongkui Xie, Ruoyu Wang
Plant growth-promoting Bacillus amyloliquefaciens FZB42 induces systemic salt tolerance in Arabidopsis and enhances the fresh and dry weight. However, the underlying molecular mechanism that allows plants to respond to FZB42 and exhibit salt tolerance is largely unknown. Therefore, we performed large-scale transcriptome sequencing of Arabidopsis shoot tissues grown under salt stress with or without FZB42 inoculation by using Illumina sequencing to identify the key genes and pathways with important roles during this interaction...
September 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28893956/cutting-edge-genetic-association-between-ifi16-single-nucleotide-polymorphisms-and-resistance-to-genital-herpes-correlates-with-ifi16-expression-levels-and-hsv-2-induced-ifn-%C3%AE-expression
#13
Kristina Eriksson, Alexandra Svensson, Alon S Hait, Kerstin Schlüter, Petra Tunbäck, Inger Nordström, Leonid Padyukov, Jan-Åke Liljeqvist, Trine H Mogensen, Søren R Paludan
IFN-γ-inducible protein 16 (IFI16) is an immunological DNA sensor proposed to act in the cyclic GMP-AMP synthase-stimulator of IFN genes pathway. Because mice do not have a clear ortholog of IFI16, this system is not suitable for genetic studies of IFI16. In this study, we have compared the dependency on IFI16, cyclic GMP-AMP synthase, and stimulator of IFN genes for type I IFN induction by a panel of pathogenic bacteria and DNA viruses. The IFN response induced by HSV-2 was particularly dependent on IFI16...
October 15, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28872094/-transcatheter-aortic-valve-implantation-present-and-development-trend
#14
Yi He, Haiting Zhou, Shuqiang Zhu, Yongbing Wu
Currently, although surgical aortic valve replacement (SAVR) is still the golden standard in treatment of severe aortic stenosis according to the guideline, transcatheter aortic valve implantation (TAVI) is gradually becoming a common treatment for patients who are prohibitive or in high risk for SAVR. Recently, the valve manufacturers, including medical companies in China, are making their utmost to develop valve device, leading remarkable results achieved by TAVI. With the complications being controlled, TAVI displays promising future...
August 28, 2017: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/28853277/ambipolar-graphene-quantum-dot-hybrid-vertical-photodetector-with-a-graphene-electrode
#15
Yongli Che, Yating Zhang, Xiaolong Cao, Haiting Zhang, Xiaoxian Song, Mingxuan Cao, Yu Yu, Haitao Dai, Junbo Yang, Guizhong Zhang, Jianquan Yao
A strategy to fabricate an ambipolar near-infrared vertical photodetector (VPD) by sandwiching a photoactive material as a channel film between the bottom graphene and top metal electrodes was developed. The channel length in the vertical architecture was determined by the channel layer thickness, which can provide an ultrashort channel length without the need for a high-precision manufacturing process. The performance of VPDs with two types of semiconductor layers, a graphene-PbS quantum dot hybrid (GQDH) and PbS quantum dots (QDs), was measured...
September 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28844345/the-effect-of-atomoxetine-a-selective-norepinephrine-reuptake-inhibitor-on-respiratory-arrest-and-cardiorespiratory-function-in-the-dba-1-mouse-model-of-sudep
#16
Haiting Zhao, Joseph F Cotten, Xiaoyan Long, Hua-Jun Feng
Sudden unexpected death in epilepsy (SUDEP) is a significant public health burden. The mechanisms of SUDEP are elusive, although cardiorespiratory dysfunction is a likely contributor. Clinical and animal studies indicate that seizure-induced respiratory arrest (S-IRA) is the primary event leading to death in many SUDEP cases. Our prior studies demonstrated that intraperitoneal (IP) injection of atomoxetine, a norepinephrine reuptake inhibitor (NRI) widely used to treat attention deficit hyperactivity disorder, suppresses S-IRA in DBA/1 mice...
August 22, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/28837508/every-other-day-dosing-of-oral-viscous-budesonide-is-not-effective-in-the-management-of-eosinophlic-esophagitis
#17
Eitan Rubinstein, Elizabeth E Hait, Paul D Mitchell, John J Lee
INTRODUCTION: Eosinophilic esophagitis (EoE) is a clinicopathologic disorder characterized histologically by esophageal eosinophilia. Oral viscous budesonide (OVB) is an effective treatment with remission rates reported between 55 and 87%; however, topical corticosteroids are associated with increased risk of candidal esophagitis and adrenal suppression. Attempts to decrease the daily dose of topical steroids have resulted in disease relapse. The objective of this study was to determine whether or not reducing the frequency of OVB administration would be effective in controlling esophageal eosinophilia in children and adolescents...
August 23, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28831025/lncrna-xist-interacts-with-mir-29c-to-modulate-the-chemoresistance-of-glioma-cell-to-tmz-through-dna-mismatch-repair-pathway
#18
Peng Du, Haiting Zhao, Renjun Peng, Qing Liu, Jian Yuan, Gang Peng, Yiwei Liao
Temozolomide (TMZ) is the most commonly used alkylating agent in glioma chemotherapy. However, growing resistance to TMZ remains a major challenge for clinicians. Recent evidence emphasizes the key regulatory roles of non-coding RNAs (lncRNAs and miRNAs) in tumor biology, including the chemoresistance of cancers. However, little is known about the role and regulation mechanisms of lncRNA cancer X-inactive specific transcripts (XIST) in glioma tumorigenesis and chemotherapy resistance. In the present study, higher XIST expression was observed in glioma tissues and cell lines, which was related to poorer clinicopathologic features and shorter survival time...
October 31, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28799393/condensed-phase-electron-transfer-beyond-the-condon-approximation
#19
Michael G Mavros, Diptarka Hait, Troy Van Voorhis
Condensed phase electron transfer problems are often simplified by making the Condon approximation: the approximation that the coupling connecting two charge-transfer diabatic states is a constant. Unfortunately, the Condon approximation does not predict the existence of conical intersections, which are ubiquitous in both gas-phase and condensed-phase photochemical dynamics. In this paper, we develop a formalism to treat condensed-phase dynamics beyond the Condon approximation. We show that even for an extremely simple test system, hexaaquairon(ii)/hexaaquairon(iii) self-exchange in water, the electronic coupling is expected to fluctuate rapidly and non-Condon effects must be considered to obtain quantitatively accurate ultrafast nonequilibrium dynamics...
December 7, 2016: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28792378/staphylococcal-enterotoxin-type-r-pseudogene-presence-in-staphylococcus-aureus-reference-and-outbreak-strains
#20
Jennifer M Hait, Reginald W Bennett, Steven R Monday
Novel staphylococcal enterotoxins (SEs) expressed by Staphylococcus aureus strains have been described throughout the years, among these being the SE protein SER. To further characterize this toxin, this research used 13 S. aureus strains previously determined to contain the SE type R (ser) gene. These S. aureus isolates were evaluated using serological assays for identification of SEA–SEE and PCR for the detection of newly described SE and SE-like enterotoxin genes seg–seu. PCR-based cloning was performed such that the ser gene could be ligated into the pTrc99A plasmid expression vector...
August 8, 2017: Journal of AOAC International
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