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Mitotic rate and nevus

Faruk Tas, Kayhan Erturk
Regression is caused by a host immunological response primarily characterized by lymphocytic infiltration directed against melanoma cells. The prognostic significance of regression remains controversial in cutaneous melanoma patients. The aim of this study was to determine the clinical significance of the histological regression status in patients with cutaneous melanoma. A total of 664 patients with a pathologically confirmed cutaneous melanoma were enrolled into this study and were investigated retrospectively...
October 2016: Melanoma Research
Tawny Hung, Zsolt Argenyi, Lori Erickson, Joan Guitart, Marcelo G Horenstein, Lori Lowe, Jane Messina, Michael W Piepkorn, Victor G Prieto, Michael S Rabkin, Birgitta Schmidt, Maria A Selim, Christopher R Shea, Martin J Trotter, Raymond L Barnhill
Cellular blue nevomelanocytic lesions (CBNLs) frequently pose diagnostic problems to pathologists, and their biological potential may be difficult to establish. In this study, the authors have analyzed the clinical, histological, and outcome data of 37 cellular blue nevomelanocytic lesions and the molecular characteristics of 4 lesions. The cohort of cases comprised 8 cellular blue nevi (CBNs), 17 atypical cellular blue nevi (ACBNs), and 12 blue-nevus-like melanomas (BNLMs) with a mean follow-up of 5 years...
July 2016: American Journal of Dermatopathology
Daniela Mihic-Probst, Chris Shea, Lyn Duncan, Arnaud de la Fouchardiere, Gilles Landman, Jennifer Landsberg, Joost ven den Oord, Lori Lowe, Martin G Cook, Sook Jung Yun, Loren Clarke, Jane Messina, David E Elder, Raymond L Barnhill
The following communication summarizes the proceedings of a 1-day Workshop of the International Melanoma Pathology Study Group, which was devoted to thin melanoma. The definitions and histologic criteria for thin melanoma were reviewed. The principal differential diagnostic problems mentioned included the distinction of thin melanoma from nevi, especially from nevi of special site, irritated nevi, inflamed and regressing nevi, and dysplastic nevi. Histologic criteria for this analysis were discussed and the importance of clinico-pathologic correlation, especially in acral sites, was emphasized...
January 2016: Advances in Anatomic Pathology
Nedeljka Glavan, Gordana Zamolo, Miljenko Katunarić, Nives Jonjić
No abstract text is available yet for this article.
2015: Acta Dermatovenerologica Croatica: ADC
R Andrei, Sabina Zurac, C Socoliuc, P Mandisodza, Florica Staniceanu
Melanoma arising from blue naevus is an exceedingly rare variant of melanoma. Most of the cases are located in head and neck area, with scalp the most affected site. This type of melanoma develops on blue naevus or resembles blue naevus, most frequently cellular blue naevus. We present the case of a 52 years old female diagnosed with a pigmented melanoma of the scalp, with maximum tumoral thickness of 6.8 mm and invasion of the hypodermis, highly resembling cellular blue naevus. All criteria of malignancy were present: prominent nuclear pleomorphism, infiltrative pattern, tumoral necrosis, high mitotic rate (11 mitoses/mm2) with atypical mitosis and high Ki67 index...
January 2015: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
Simone Ribero, John R Davies, Celia Requena, Cristina Carrera, Daniel Glass, Ramon Rull, Sergi Vidal-Sicart, Antonio Vilalta, Lucia Alos, Virtudes Soriano, Pietro Quaglino, Victor Traves, Julia A Newton-Bishop, Eduardo Nagore, Josep Malvehy, Susana Puig, Veronique Bataille
A high number of nevi is the most significant phenotypic risk factor for melanoma and is in part genetically determined. The number of nevi decreases from middle age onward but this senescence can be delayed in patients with melanoma. We investigated the effects of nevus number count on sentinel node status and melanoma survival in a large cohort of melanoma cases. Out of 2,184 melanoma cases, 684 (31.3%) had a high nevus count (>50). High nevus counts were associated with favorable prognostic factors such as lower Breslow thickness, less ulceration and lower mitotic rate, despite adjustment for age...
October 1, 2015: International Journal of Cancer. Journal International du Cancer
Daniela Massi, Carlo Tomasini, Rebecca Senetta, Milena Paglierani, Francesca Salvianti, Maria Elena Errico, Vittoria Donofrio, Paola Collini, Gabrina Tragni, Angela Rita Sementa, Franco Rongioletti, Renata Boldrini, Andrea Ferrari, Claudio Gambini, Maria Cristina Montesco
BACKGROUND: Diagnosis and proper management of atypical Spitz tumors in pediatric age are still controversial. OBJECTIVE: We sought to investigate the clinicopathological and molecular features of atypical Spitz tumors in patients aged 18 years or younger. METHODS: We performed a retrospective clinicopathological and fluorescence in situ hybridization study on 50 pediatric atypical Spitz tumors. RESULTS: Parameters that were significantly correlated with a diagnosis of atypical Spitz tumors over Spitz nevus included asymmetry, level IV/V, lack of maturation, solid growth, nuclear pleomorphism, high nuclear-cytoplasmic ratio, atypical and deep mitoses, and more than 6 mitoses/mm(2)...
January 2015: Journal of the American Academy of Dermatology
Tawny Hung, Aparche Yang, Martin C Mihm, Raymond L Barnhill
The plexiform spindle cell nevus (PLXSCN) is a distinct melanocytic lesion that often provokes concern for melanoma. We describe the features of 119 typical PLXSCNs and 9 atypical/high-grade lesions. Histologically, all cases had a fascicular plexiform architecture and were composed of predominately spindled cells. The 6 atypical plexiform spindle cell tumors (PLXSCTs) exhibited features such as greater mitotic activity, increased cellularity/nodular confluence, and more concerning cytological atypia. Three high-grade tumors (perhaps evolving plexiform spindle cell melanomas) had additional alarming clinical or histologic characteristics, such as patient age greater than 40 years, greater degree of cellularity, higher degree of cytological atypia, mitotic rate greater than 3/mm(2), regional lymph node metastases, and greater than 1 positive sentinel lymph node...
December 2014: Human Pathology
Nancy E Thomas, Anne Kricker, Weston T Waxweiler, Patrick M Dillon, Klaus J Busman, Lynn From, Pamela A Groben, Bruce K Armstrong, Hoda Anton-Culver, Stephen B Gruber, Loraine D Marrett, Richard P Gallagher, Roberto Zanetti, Stefano Rosso, Terence Dwyer, Alison Venn, Peter A Kanetsky, Irene Orlow, Susan Paine, David W Ollila, Anne S Reiner, Li Luo, Honglin Hao, Jill S Frank, Colin B Begg, Marianne Berwick
IMPORTANCE Previous studies have reported that histopathologically amelanotic melanoma is associated with poorer survival than pigmented melanoma; however, small numbers of amelanotic melanomas, selected populations, lack of centralized pathologic review, or no adjustment for stage limit the interpretation or generalization of results from prior studies.OBJECTIVE To compare melanoma-specific survival between patients with histopathologically amelanotic and those with pigmented melanoma in a large international population-based study...
December 2014: JAMA Dermatology
Albert Su, Lawrence Low, Xinmin Li, Shengmei Zhou, Leo Mascarenhas, Raymond L Barnhill
Congenital melanoma is extraordinarily rare, and 3 types have been described: transplacental metastases from the mother, de novo congenital melanoma, and melanoma occurring in association with a congenital melanocytic nevus. We describe 2 reports of array comparative genomic hybridization analysis of de novo congenital melanoma. The first patient was male, and the second was female; both had a scalp lesion present at birth, which grew quickly. The scalp mass from patient 1 showed a heterogeneous, anaplastic melanocytic neoplasm with large size and depth, high mitotic rate, ulceration, and necrosis...
November 2014: American Journal of Dermatopathology
R Betti, R Santambrogio, A Cerri, R Vergani, L Moneghini, S Menni
BACKGROUND: Melanomas can arise from naevi or appear de novo. The frequency or the effect of their origin on prognosis is still debated. Mitotic rate (MR) and ulceration of melanomas have been proposed as further new prognostic indexes. AIM: To determine the different prognostic factors in melanomas de novo and melanomas from pre-existing naevi and whether these two melanoma groups have different MR or presence of ulceration. METHODS: All patients with confirmed primary melanomas observed in our clinic from 1996 to July 2013 were included...
December 2014: Journal of the European Academy of Dermatology and Venereology: JEADV
Pedram Gerami, Klaus Busam, Alistair Cochran, Martin G Cook, Lyn M Duncan, David E Elder, Douglas R Fullen, Joan Guitart, Philip E LeBoit, Martin C Mihm, Victor G Prieto, Michael S Rabkin, Richard A Scolyer, Xiaowei Xu, Sook Jung Yun, Roxana Obregon, Pedram Yazdan, Chelsea Cooper, Bing Bing Weitner, Alfred Rademaker, Raymond L Barnhill
Predicting clinical behavior of atypical Spitz tumors remains problematic. In this study, we assessed interobserver agreement of diagnosis by 13 expert dermatopathologists for atypical Spitz tumors (n=75). We determined which histomorphologic features were most heavily weighted for their diagnostic significance by the experts and also which histomorphologic features had a statistically significant correlation with clinical outcome. There was a low interobserver agreement among the experts in categorizing lesions as malignant versus nonmalignant (κ=0...
July 2014: American Journal of Surgical Pathology
James Maher, Alan Cameron, Sharon Wallace, Rafael Acosta-Rojas, David Weedon, Cliff Rosendahl
Balloon cell melanoma is a rare melanoma subtype, with only one previous case with dermatoscopy published. It is often non-pigmented, leading to diagnostic difficulty, and there is a tendency for lesions to be thick at diagnosis. We report a case of balloon cell melanoma on the forearm of a 61-year-old man with both polarized and non-polarized dermatoscopy and dermatopathology. It presented as a firm pale nodule with focal eccentric pigmentation. The clinical images evoke a differential diagnosis of dermatofibroma, dermal nevus, Spitz nevus and basal cell carcinoma as well as melanoma...
January 2014: Dermatology Practical & Conceptual
Lisa Shen, Chelsea Cooper, Shirin Bajaj, Ping Liu, Ekaterina Pestova, Joan Guitart, Pedram Gerami
Determining risk assessment for aggressive behavior of atypical Spitz tumors (ASTs) remains a significant challenge for pathologists. Despite the presence of many concerning histological features such as tumor ulceration, expansile growth, dermal mitotic rate, and cytological atypia, the overwhelming majority of these tumors behave in an indolent fashion. Recently, we have noted that using cytogenetics, one can identify ASTs with high likelihood for aggressive behavior allowing for a clinically significant risk assessment...
December 2013: American Journal of Dermatopathology
Laura Held, Thomas K Eigentler, Gisela Metzler, Ulrike Leiter, Jane L Messina, L Frank Glass, Claus Garbe, Jürgen Bauer
Blue nevi are a clinically and pathologically heterogeneous group of benign pigmented dermal melanocytic tumors that may exhibit histologic overlap with malignant melanoma. This study evaluates the role of immunohistochemical and molecular analyses in the classification and differential diagnosis between blue nevi and melanoma. Twenty-three dermal melanocytic tumors, initially diagnosed as benign or ambiguous, were subjected to immunohistochemical staining for phosphohistone H3 and MIB-1 to evaluate mitotic activity, comparative genomic hybridization to detect chromosomal aberrations, and GNAQ, GNA11, BRAF, NRAS, and KRAS sequencing...
March 2013: American Journal of Pathology
Laura Held, Gisela Metzler, Thomas K Eigentler, Ulrike Leiter, Jane Messina, Jeannette Gogel, Juergen Bauer, Claus Garbe
Plaque-type blue nevus is a rare variant of blue nevus characterized by grouped nodules displaying histomorphological features of a cellular blue nevus. We report the clinical, histopathologic and immunohistologic features of a patient with recurrent nodules in a periauricular plaque-type blue nevus with malignant transformation and fatal outcome. The nevus was characterized clinically by childhood onset, with slow enlargement during adolescence. At age 16, the patient presented with nodules located retroauricularly...
December 2012: Journal of Cutaneous Pathology
S Paradela, E Fonseca, S Pita-Fernández, V G Prieto
BACKGROUND: Spitzoid melanoma is a rare melanoma subtype often developing in children with unknown biological potential. OBJECTIVES: To compare the clinical and histopathological factors that influence the biological behaviour between spitzoid and non-spitzoid childhood melanoma, to establish if the spitzoid subset of melanoma has different prognosis than other types of childhood melanomas. METHODS: A comparison of the prognostic significance of clinical and pathological findings between 38 spitzoid (SM) and 99 non-spitzoid melanomas (N-SM) in children and teenagers younger than 18 years referred to UT - MD Anderson Cancer Center during the period 1992-2007...
October 2013: Journal of the European Academy of Dermatology and Venereology: JEADV
Ana Alekseenko, Anna Wojas-Pelc, Grzegorz J Lis, Zdzisław Wiśniowski, Magdalena Czerwińska, Łukasz Niewiara, Jan A Litwin
Cyclins play a fundamental role in the cell cycle. Recent studies have focused on their role in the development of various malignancies. The objective of this study was to evaluate and compare the expression of cyclins A and E in common nevi, dysplastic nevi and malignant melanomas, and to investigate the relationship between cyclin expression and some pathological parameters such as tumor thickness, ulceration, regression, and mitotic rate, as well as several clinical and phenotypic parameters such as skin phototype, hair and eye color, number of nevi, personal or family melanoma history, and personal history of nonmelanoma skin cancer (NMSC)...
2012: Folia Histochemica et Cytobiologica
Hannah E Cottom, Faten I Bshena, Paul M Speight, Geoffrey T Craig, Adam V Jones
BACKGROUND: Odontogenic keratocysts (OKCs) constitute between 1.8% and 21.5% of odontogenic cysts and are associated with higher propensity to recur than other odontogenic cysts following surgical removal. Previous studies have been performed to identify clinico-pathological predictive factors in relation to such behaviour. The relationship between the presence of hyalinisation and recurrence of the OKC has not been explored. METHODS: A total of 110 OKCs were selected, comprising 53 non-recurrent cases, 50 cases known to subsequently recur and seven syndromic cases...
May 2012: Journal of Oral Pathology & Medicine
Raymond L Barnhill, Heinz Kutzner, Birgitta Schmidt, Liaqat Ali, Martine Bagot, Anne Janin, Claire Lugassy
Atypical spitzoid melanocytic neoplasms (ASMN) may prove difficult to distinguish microscopically from melanoma, and their biological behavior may be unpredictable. ASMN may result in regional lymph node (LN) metastases and frequent sentinel lymph node (SLN) deposits. Angiotropism and extravascular migratory metastasis may account for locoregional metastases in melanoma and thus may potentially explain such locoregional involvement in ASMN. Nine ASMN with angiotropism from 2006 to 2010 were studied. Angiotropism was defined as melanocytes closely opposed to the external surfaces of microvascular channels without intravasation...
May 2011: American Journal of Dermatopathology
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