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Mitotic rate and melanoma

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https://www.readbyqxmd.com/read/27887797/mortality-burden-and-prognosis-of-thin-melanomas-overall-and-by-subcategory-of-thickness-seer-registry-data-1992-2013
#1
Shoshana M Landow, Annie Gjelsvik, Martin A Weinstock
BACKGROUND: Thin melanomas cause a high death toll despite excellent prognosis. OBJECTIVE: We examined melanoma mortality burden and prognosis by categories of thickness within Surveillance, Epidemiology, and End Results (SEER) 13 Registry 1992-2013. METHODS: We divided 49,319 stage I and II melanoma cases diagnosed between 1992 and 2003 into T1 through T4 and then subdivided T1 into 0.01-0.25 mm, 0.26-0.50 mm, 0.51-0.75 mm, and 0.76-1...
November 22, 2016: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/27864417/tumor-thickness-and-mitotic-rate-robustly-predict-melanoma-specific-survival-in-patients-with-primary-vulvar-melanoma-a-retrospective-review-of-100-cases
#2
Priyadharsini Nagarajan, Jonathan L Curry, Jing Ning, Jin Piao, Carlos A Torres Cabala, Phyu P Aung, Doina Ivan, Merrick I Ross, Charles F Levenback, Michael Frumovitz, Jeffrey E Gershenwald, Michael A Davies, Anais Malpica, Victor Prieto, Michael T Tetzlaff
PURPOSE: Primary vulvar melanoma (PVM) is the second most common vulvar malignancy. Despite their distinct anatomic site and unique molecular-genetic alterations, PVMs are staged according to the American Joint Committee on Cancer (AJCC) guidelines for primary cutaneous melanomas (PCM). However, whether parameters derived for PCM also apply to PVM remains a critical yet largely unexplored clinical question. The objective of this study was to determine the parameters predictive of survival in PVM...
November 18, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/27847125/mitotic-rate-correlates-with-sentinel-lymph-node-status-and-outcome-in-cutaneous-melanoma-greater-than-1%C3%A2-millimeter-in-thickness-a-multi-institutional-study-of-1524-cases
#3
Mario Mandalà, Francesca Galli, Laura Cattaneo, Barbara Merelli, Eliana Rulli, Simone Ribero, Pietro Quaglino, Vincenzo De Giorgi, Jacopo Pigozzo, Vanna Chiarion Sileni, Alessandra Chirco, Pier Francesco Ferrucci, Marcella Occelli, Gianlorenzo Imberti, Dario Piazzalunga, Daniela Massi, Carlo Tondini, Paola Queirolo
BACKGROUND: The 7th edition of the TNM American Joint Committee on Cancer classification incorporates mitotic rate (MR) only for primary cutaneous melanoma (PCM) with Breslow thickness (BT) ≤1 mm. OBJECTIVE: To investigate whether and to what extent MR is able to predict sentinel lymph node (SLN) status and clinical outcome of PCM patients with BT >1 mm. METHODS: The study included consecutive patients with PCM. Logistic regression and Cox regression model were used to analyze the impact of MR on SLN status, disease-free survival (DFS), and overall survival...
November 12, 2016: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/27807664/intercellular-crosstalk-in-human-malignant-melanoma
#4
REVIEW
Barbora Dvořánková, Pavol Szabo, Ondřej Kodet, Hynek Strnad, Michal Kolář, Lukáš Lacina, Eliška Krejčí, Ondřej Naňka, Aleksi Šedo, Karel Smetana
Incidence of malignant melanoma is increasing globally. While the initial stages of tumors can be easily treated by a simple surgery, the therapy of advanced stages is rather limited. Melanoma cells spread rapidly through the body of a patient to form multiple metastases. Consequently, the survival rate is poor. Therefore, emphasis in melanoma research is given on early diagnosis and development of novel and more potent therapeutic options. The malignant melanoma is arising from melanocytes, cells protecting mitotically active keratinocytes against damage caused by UV light irradiation...
November 3, 2016: Protoplasma
https://www.readbyqxmd.com/read/27778319/histological-lymphovascular-invasion-is-associated-with-nodal-involvement-recurrence-and-survival-in-patients-with-cutaneous-malignant-melanoma
#5
Faruk Tas, Kayhan Erturk
BACKGROUND: Invasion of the lymphatic or vascular vessels by the primary tumor is considered a sign of aggressive disease that leads to metastases to the regional lymph nodes and to distant sites. Although lymphovascular invasion (LVI) is one of the major characteristics of a primary melanoma tumor, its prognostic significance remains controversial. OBJECTIVE: The objective of this study was to determine the clinical significance of LVI in melanoma patients. METHODS: Outcomes in 705 patients with cutaneous melanoma were investigated retrospectively...
October 25, 2016: International Journal of Dermatology
https://www.readbyqxmd.com/read/27775232/sentinel-lymph-node-biopsy-for-ocular-adnexal-melanoma
#6
Margaret L Pfeiffer, Omar K Ozgur, Jeffrey N Myers, Andrew Peng, Jing Ning, Mark E Zafereo, Sudip Thakar, Bradley Thuro, Victor G Prieto, Merrick I Ross, Bita Esmaeli
BACKGROUND: We sought to update our prior report of findings on sentinel lymph node biopsy (SLNB) and predictors of a positive SLN in patients with conjunctival or eyelid melanoma. METHODS: We reviewed the records of all patients with ocular adnexal melanoma who underwent SLNB at one institution during 2000-2015. We determined rates of positive and false-negative findings on SLNB, primary tumour features correlated with positive findings and rate of nodal recurrence (false-negative event) after negative findings...
October 24, 2016: Acta Ophthalmologica
https://www.readbyqxmd.com/read/27766186/prediction-of-positron-emission-tomography-computed-tomography-pet-ct-positivity-in-patients-with-high-risk-primary-melanoma
#7
Maria Danielsen, Andreas Kjaer, Max Wu, Lea Martineau, Mehdi Nosrati, Stanley Pl Leong, Richard W Sagebiel, James R Miller Iii, Mohammed Kashani-Sabet
Positron emission tomography/computed tomography (PET/CT) is an important tool to identify occult melanoma metastasis. To date, it is controversial which patients with primary cutaneous melanoma should have staging PET/CT. In this retrospective analysis of more than 800 consecutive patients with cutaneous melanoma, we sought to identify factors predictive of PET/CT positivity in the setting of newly-diagnosed high-risk primary melanoma to determine those patients most appropriate to undergo a PET/CT scan as part of their diagnostic work up...
2016: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27713424/5-hydroxymethylcytosine-is-an-independent-predictor-of-survival-in-malignant-melanoma
#8
Gerald Saldanha, Kushal Joshi, Kathryn Lawes, Mark Bamford, Farhaan Moosa, Kah Wee Teo, J Howard Pringle
Outcomes for melanoma patients vary within cancer stage. Prognostic biomarkers are potential adjuncts to provide more precise prognostic information. Simple, low-cost biomarker assays, such as those based on immunohistochemistry, have strong translational potential. 5-hydroxymethylcytosine (5 hmC) shows prognostic potential in melanoma but prior studies were small. We, therefore, analysed 5 hmC in a retrospective cohort to provide external validation of its prognostic value. Two hundred primary melanomas were evaluated for 5 hmC expression using immunohistochemistry...
October 7, 2016: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/27709599/cathepsin-k-expression-in-melanoma-is-associated-with-metastases
#9
Slavica Juric Petricevic, Antonia Pavlovic, Vesna Capkun, Kristijan Becic, Merica Glavina Durdov
Introduction Melanoma of the skin shows a tendency to metastasize via lymph or blood secreting matrix metalloproteinases and cathepsins, which enable penetration through the dermis. Cathepsin K acts in cytoplasm of atypical melanocytes and completely cleaves internalized collagen. Materials and methods Expression of cathepsin K was analyzed immunohistochemically in 45 melanomas and correlated to morphological and clinical parameters. Results During six years follow up, 13 patients developed lymph node metastases and three of them distant metastases...
October 6, 2016: Histology and Histopathology
https://www.readbyqxmd.com/read/27706081/golgi-related-proteins-golph2-gp73-golm1-and-golph3-gopp1-midas-in-cutaneous-melanoma-patterns-of-expression-and-prognostic-significance
#10
Piotr Donizy, Maciej Kaczorowski, Przemyslaw Biecek, Agnieszka Halon, Teresa Szkudlarek, Rafal Matkowski
GOLPH2 and GOLPH3 are Golgi-related proteins associated with aggressiveness and progression of a number of cancers. Their prognostic significance in melanoma has not yet been analyzed. We performed immunohistochemical analysis for GOLPH2 and GOLPH3 in 20 normal skin, 30 benign nevi and 100 primary melanoma tissue samples and evaluated their expression in three compartments: cancer cells, tumor-associated macrophages (TAMs) and cancer-associated fibroblasts (CAFs). High levels of both proteins in melanoma cells were associated with characteristics of aggressive disease, and shorter disease-free survival (DFS) and cancer-specific overall survival (CSOS)...
October 1, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27607033/mitotic-rate-in-primary-melanoma-interobserver-and-intraobserver-reliability-analyzed-using-h-e-sections-and-immunohistochemistry
#11
Claus Garbe, Thomas K Eigentler, Jürgen Bauer, Norbert Blödorn-Schlicht, Lorenzo Cerroni, Falko Fend, Markus Hantschke, Peter Kurschat, Heinz Kutzner, Dieter Metze, Volker Mielke, Harald Preßler, Michael Reusch, Ursula Reusch, Rudolf Stadler, Michael Tronnier, Amir Yazdi, Gisela Metzler
BACKGROUND: In 2009, the AJCC issued a revised melanoma staging system. In addition to tumor thickness and ulceration, the mitotic rate was introduced as the third major prognostic parameter for the classification of primary cutaneous melanoma. Given that, according to the 2009 AJCC classification, the detection of one or more dermal tumor mitoses leads to an upstaging - from stage Ia to Ib - of melanomas with a tumor thickness of ≤ 1.0 mm, we set out to investigate the reproducibility of this new parameter...
September 2016: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/27602146/an-observational-study-regarding-the-rate-of-growth-in-vertical-and-radial-growth-phase-superficial-spreading-melanomas
#12
Roberto Betti, Elena Agape, Raffaella Vergani, Laura Moneghini, Amilcare Cerri
The natural history of superficial spreading melanomas (SSMs) involves the progression from a radial growth phase (RGP) to a vertical growth phase (VGP). Currently, a patient's history represents the only method to estimate the rate of tumor growth. The present study aimed to verify whether the estimated rate of growth (ROG) of SSMs with a RGP or VGP exhibited any differences, and to evaluate the possible implications for the most important prognostic determinants. ROG was quantified as the ratio between Breslow's thickness in millimeters (mm) and the time of tumor growth in months, defined as the time between the date that the patient had first noticed the lesion in which melanoma subsequently developed and the date on which the patient first felt this lesion changed...
September 2016: Oncology Letters
https://www.readbyqxmd.com/read/27545198/acral-melanoma-in-chinese-a-clinicopathological-and-prognostic-study-of-142-cases
#13
Jiaojie Lv, Bo Dai, Yunyi Kong, Xuxia Shen, Jincheng Kong
Acral melanoma (AM), as a peculiar subgroup of melanoma, is rare in Caucasians but has higher incidence in Asians. Large series of study on AM with clinicopathological features and prognostic factors is still limited, especially in Asian population. We retrospectively collected clinical, pathological and follow-up data of 142 AM cases. All patients were Chinese, with the age ranging from 24 to 87 years (mean 62.0; median 62.0). The Breslow thickness of primary lesions ranged from 0.6 to 16.3 mm (mean 4.9; median 3...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27380112/presence-of-histological-regression-as-a-prognostic-factor-in-cutaneous-melanoma-patients
#14
Faruk Tas, Kayhan Erturk
Regression is caused by a host immunological response primarily characterized by lymphocytic infiltration directed against melanoma cells. The prognostic significance of regression remains controversial in cutaneous melanoma patients. The aim of this study was to determine the clinical significance of the histological regression status in patients with cutaneous melanoma. A total of 664 patients with a pathologically confirmed cutaneous melanoma were enrolled into this study and were investigated retrospectively...
October 2016: Melanoma Research
https://www.readbyqxmd.com/read/27266393/the-effect-of-time-to-sentinel-lymph-node-biopsy-on-cutaneous-melanoma-survival
#15
Cristina Fortes, Simona Mastroeni, Alessio Caggiati, Francesca Passarelli, Alba Zappalà, Maria Capuano, Riccardo Bono, Maurizio Nudo, Claudia Marino, Paola Michelozzi
BACKGROUND: Whether timing of sentinel lymph node biopsy (SLNB) in cutaneous melanoma improves survival is not yet clear. The aim of this study was to investigate if the timing of SLNB influences long-term melanoma mortality. METHODS: A 10-year retrospective cohort study was conducted on 748 cutaneous melanoma patients who underwent excision of the SLN. Hazard ratios and 95% confidence intervals were estimated from Cox proportional hazards models. RESULTS: After adjusting for sex, age, Breslow thickness, mitotic rate, ulceration, and histologic type, patients who underwent early SLNB (≤30 days) and resulted positive on final pathology had a 3 times decreased risk of melanoma mortality (hazard ratio = ...
November 2016: American Journal of Surgery
https://www.readbyqxmd.com/read/27239117/primary-hepatic-epithelioid-angiomyolipoma-a-malignant-potential-tumor-which-should-be-recognized
#16
Jie Liu, Cheng-Wu Zhang, De-Fei Hong, Ran Tao, Yuan Chen, Min-Jie Shang, Yu-Hua Zhang
AIM: To improve the clinical diagnosis and recognition of hepatic epithelioid angiomyolipoma (HEAML). METHODS: Four cases of primary HEAML were confirmed based on the pathology archive system in our hospital from January 2009 to November 2015. The general state, clinical symptoms, imaging manifestations, histological results and immunohistochemistry of these patients were retrospectively reviewed and analyzed. Studies of HEAML published in the last 15 years were collected from PubMed and MEDLINE to summarize the clinical symptoms, imaging characteristics, pathological features and management of HEAML...
May 28, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27023017/value-of-sentinel-lymph-node-biopsy-and-adjuvant-interferon-treatment-in-thick-4-mm-cutaneous-melanoma-an-observational-study
#17
Natalia Morera-Sendra, Antonio Tejera-Vaquerizo, Víctor Traves, Celia Requena, Isidro Bolumar, Angel Pla, Carlos Vázquez, Virtudes Soriano, Eduardo Nagore
BACKGROUND: The role of sentinel lymph node biopsy and the benefit of immunotherapy with interferon in thick (>4 mm) melanomas remain uncertain. OBJECTIVES: Our aim was to assess the value of both sentinel lymph node (SLN) biopsy and immunotherapy in the prognosis of thick melanomas. METHODS: A retrospective study based on a computerized patient database in which patients have been prospectively collected since 2005 was performed. Age, sex, location, Breslow thickness, tumor ulceration, regression, Clark level, tumor infiltrating lymphocytes, tumor mitotic rate, microscopic satellite and vascular invasion were included in the analysis...
January 2016: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/27020389/satellite-in-transit-metastases-in-rapidly-fatal-conjunctival-melanoma-implications-for-angiotropism-and-extravascular-migratory-metastasis-description-of-a-murine-model-for-conjunctival-melanoma
#18
Raymond L Barnhill, Stéphanie Lemaitre, Christine Lévy-Gabrielle, Manuel Rodrigues, Laurence Desjardins, Rémi Dendale, Anne Vincent-Salomon, Sergio Roman-Roman, Claire Lugassy, Nathalie Cassoux
Little information is currently available concerning loco-regional metastases such as satellite and in transit metastases and their natural history in conjunctival melanoma as compared to cutaneous melanoma. Angiotropism, a marker of extravascular migration of melanoma cells along vascular channels, often appears responsible for microscopic satellite, satellite and in transit metastases development in cutaneous melanoma. In addition, diffuse tissue microscopic satellites are correlated with widespread melanoma dissemination and death...
February 2016: Pathology
https://www.readbyqxmd.com/read/26986135/elevated-serum-leptin-levels-are-associated-with-an-increased-risk-of-sentinel-lymph-node-metastasis-in-cutaneous-melanoma
#19
Junna Oba, Wei Wei, Jeffrey E Gershenwald, Marcella M Johnson, Cynthia M Wyatt, Julie A Ellerhorst, Elizabeth A Grimm
The metabolic hormone leptin has been implicated in the pathogenesis of various malignancies and may contribute to the high rate of cancer in obese individuals. We reported that leptin and its receptor are expressed by melanoma tumors and cell lines, and that leptin stimulates proliferation of cultured melanoma cells. Here, we tested the hypothesis that leptin contributes to early melanoma progression by assessing its association with sentinel node positivity in cutaneous melanoma patients. The study enrolled 72 patients who were scheduled to undergo lymphatic mapping and sentinel node biopsy...
March 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/26909585/cellular-blue-nevomelanocytic-lesions-analysis-of-clinical-histological-and-outcome-data-in-37-cases
#20
Tawny Hung, Zsolt Argenyi, Lori Erickson, Joan Guitart, Marcelo G Horenstein, Lori Lowe, Jane Messina, Michael W Piepkorn, Victor G Prieto, Michael S Rabkin, Birgitta Schmidt, Maria A Selim, Christopher R Shea, Martin J Trotter, Raymond L Barnhill
Cellular blue nevomelanocytic lesions (CBNLs) frequently pose diagnostic problems to pathologists, and their biological potential may be difficult to establish. In this study, the authors have analyzed the clinical, histological, and outcome data of 37 cellular blue nevomelanocytic lesions and the molecular characteristics of 4 lesions. The cohort of cases comprised 8 cellular blue nevi (CBNs), 17 atypical cellular blue nevi (ACBNs), and 12 blue-nevus-like melanomas (BNLMs) with a mean follow-up of 5 years...
July 2016: American Journal of Dermatopathology
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