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Mitotic rate and melanoma

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https://www.readbyqxmd.com/read/28128089/thin-melanoma-a-generic-term-including-four-histological-subtypes-of-cutaneous-melanoma
#1
Luca Roncati, Teresa Pusiol, Francesco Piscioli
Today, the scientific community is focusing on the prognostic significance of different histological subtypes of thin melanoma (1). The current staging system for melanoma of the American Joint Committee on Cancer (AJCC) uses Breslow thickness as the primary attribute: melanomas with up to 1 mm thickness is defined as thin, because they present a good prognosis after surgical excision, with a 10-year survival rate of 85-90% in case of a tumor-free margin ≥1 cm (2). There is a significant interaction between mitotic rate and Breslow depth, so the predictive value of the mitotic rate on sentinel lymph node (SLN) positivity can be dependent on Breslow thickness (3)...
December 2016: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/28121641/suboptimal-compliance-with-national-comprehensive-cancer-network-melanoma-guidelines-who-is-at-risk
#2
Andrew M Blakely, Danielle S Comissiong, Michael P Vezeridis, Thomas J Miner
BACKGROUND: National Comprehensive Cancer Network (NCCN) melanoma treatment guidelines are based on best available literature. We evaluated NCCN excision margin and sentinel lymph node biopsy (SLNB) guideline adherence to identify patient populations at risk for suboptimal care. METHODS: Retrospective review of prospectively maintained database of all patients who underwent operation for invasive melanoma from January 2005 to 2015. RESULTS: In total, 865 patients underwent operation for 522 thin (60...
January 24, 2017: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28116802/mitotic-figures-and-the-evolving-staging-of-melanoma
#3
Thomas N Helm
The seventh edition of the American Joint Committee on Cancer (AJCC)'s staging manual identified tumor thickness, ulceration, and mitotic figures as important adverse prognostic factors for survival. Identification of a single mitosis prompted staging of a tumor as T1b and prompted consideration of sentinel lymph node biopsy (SLNB). Careful review of survival data has shown that the identification of mitotic figures in melanoma is not an independent variable but linked to thickness and ulceration. The updated eighth edition of the AJCC's cancer staging manual reflects this understanding by stratifying thin melanomas by depth of invasion and ulceration rather than including mitotic rate...
January 24, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28109000/implementation-of-the-7th-edition-ajcc-staging-system-effects-on-staging-and-survival-for-pt1-melanoma-a-dutch-population-based-study
#4
C M C Oude Ophuis, M W J Louwman, D J Grünhagen, C Verhoef, A C J van Akkooi
: In the 7(th) edition of the AJCC staging system the mitotic rate criterion replaced Clark level to increase correct classification of high risk thin melanoma patients (pT1B). Additionally, sentinel node biopsy (SNB) was recommended for nodal staging for pT1B melanomas. AIM: to evaluate the effects on pT1 substaging and clinical implications in the national pT1 melanoma population. All pT1 melanomas diagnosed in the Netherlands between 2003-2014 were selected from the Netherlands Cancer Registry (IKNL)...
January 20, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28107565/idermatopath-a-novel-software-tool-for-mitosis-detection-in-h-e-stained-tissue-sections-of-malignant-melanoma
#5
C Andres, B Andres-Belloni, R Hein, T Biedermann, A Schäpe, N Brieu, R Schönmeyer, M Yigitsoy, J Ring, G Schmidt, N Harder
BACKGROUND: Malignant Melanoma (MM) is characterized by a growing incidence and a high malignant potential. Beside well defined prognostic factors such as tumor thickness and ulceration, the Mitotic Rate (MR) was included in the AJCC recommendations for diagnosis and treatment of MM. In daily routine, the identification of a single mitosis can be difficult on Hematoxylin&Eosin slides alone. Several studies showed a big inter- and intra-individual variability in detecting the MR in MM even by very experienced investigators, thus raising the question for a computer assisted method...
January 20, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28093638/depletion-of-p42-3-gene-inhibits-proliferation-and-invasion-in-melanoma-cells
#6
Hui Liu, Min Zhu, Zhongwu Li, Yan Wang, Rui Xing, Youyong Lu, Weicheng Xue
PURPOSE: The p42.3 gene is identified recently, and the upregulated expression has been characterized in a variety of human cancers and embryonic tissues but not yet in malignant melanoma. In this study, we explored the role of p42.3 gene in the development of melanoma. METHODS: The expression of p42.3 was detected by immunohistochemistry staining of 261 cases of patient lesions, including nevi and melanoma, and its correlation with clinical pathological characteristics and prognosis was analyzed...
January 16, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28036288/vitamin-d-deficiency-is-associated-with-a-worse-prognosis-in-metastatic-melanoma
#7
Dmitriy Timerman, Melissa McEnery-Stonelake, Cara J Joyce, Vinod E Nambudiri, F Stephen Hodi, Elizabeth B Claus, Nageatte Ibrahim, Jennifer Y Lin
Vitamin D deficiency (≤20 ng/mL) is associated with an increased incidence and worse prognosis of various types of cancer including melanoma. A retrospective, single-center study of individuals diagnosed with melanoma from January 2007 through June 2013 who had a vitamin D (25(OH)D3) level measured within one year of diagnosis was performed to determine whether vitamin D deficiency and repletion are associated with melanoma outcome. A total of 409 individuals diagnosed with histopathology-confirmed melanoma who had an ever measured serum 25(OH)D3 level were identified...
January 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/27935036/sentinel-node-metastasis-mitotic-rate-sn-mmr-as-a-prognostic-indicator-of-rapidly-progressing-disease-in-patients-with-sentinel-node-positive-melanomas
#8
Cornelia Baum, Christel Weiss, Christoffer Gebhardt, Jochen Utikal, Alexander Marx, Wolfgang Koenen, Cyrill Géraud
Risk stratification of sentinel lymph node biopsy (SNB)-positive patients with malignant melanoma differs among current classification systems. To improve classification of patients with rapidly progressive disease who may profit from adjuvant therapy with novel immune or targeted treatment modalities, a single-center retrospective analysis was performed including all melanoma patients diagnosed with a positive SN at a university-based skin cancer center over a 10-year period (2002-2012) (96 of 419 patients)...
December 9, 2016: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27887797/mortality-burden-and-prognosis-of-thin-melanomas-overall-and-by-subcategory-of-thickness-seer-registry-data-1992-2013
#9
Shoshana M Landow, Annie Gjelsvik, Martin A Weinstock
BACKGROUND: Thin melanomas cause a high death toll despite excellent prognosis. OBJECTIVE: We examined melanoma mortality burden and prognosis by categories of thickness within Surveillance, Epidemiology, and End Results (SEER) 13 Registry 1992-2013. METHODS: We divided 49,319 stage I and II melanoma cases diagnosed between 1992 and 2003 into T1 through T4 and then subdivided T1 into 0.01-0.25 mm, 0.26-0.50 mm, 0.51-0.75 mm, and 0.76-1...
February 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/27864417/tumor-thickness-and-mitotic-rate-robustly-predict-melanoma-specific-survival-in-patients-with-primary-vulvar-melanoma-a-retrospective-review-of-100-cases
#10
Priyadharsini Nagarajan, Jonathan L Curry, Jing Ning, Jin Piao, Carlos A Torres-Cabala, Phyu P Aung, Doina Ivan, Merrick I Ross, Charles F Levenback, Michael Frumovitz, Jeffrey E Gershenwald, Michael A Davies, Anais Malpica, Victor G Prieto, Michael T Tetzlaff
PURPOSE: Primary vulvar melanoma (PVM) is the second most common vulvar malignancy. Despite their distinct anatomic site and unique molecular-genetic alterations, PVMs are staged according to the American Joint Committee on Cancer (AJCC) guidelines for primary cutaneous melanomas (PCM). However, whether parameters derived for PCM also apply to PVM remain a critical yet largely unexplored clinical question. The objective of this study was to determine the parameters predictive of survival in PVM...
November 18, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/27847125/mitotic-rate-correlates-with-sentinel-lymph-node-status-and-outcome-in-cutaneous-melanoma-greater-than-1%C3%A2-millimeter-in-thickness-a-multi-institutional-study-of-1524-cases
#11
Mario Mandalà, Francesca Galli, Laura Cattaneo, Barbara Merelli, Eliana Rulli, Simone Ribero, Pietro Quaglino, Vincenzo De Giorgi, Jacopo Pigozzo, Vanna Chiarion Sileni, Alessandra Chirco, Pier Francesco Ferrucci, Marcella Occelli, Gianlorenzo Imberti, Dario Piazzalunga, Daniela Massi, Carlo Tondini, Paola Queirolo
BACKGROUND: The 7th edition of the TNM American Joint Committee on Cancer classification incorporates mitotic rate (MR) only for primary cutaneous melanoma (PCM) with Breslow thickness (BT) ≤1 mm. OBJECTIVE: To investigate whether and to what extent MR is able to predict sentinel lymph node (SLN) status and clinical outcome of PCM patients with BT >1 mm. METHODS: The study included consecutive patients with PCM. Logistic regression and Cox regression model were used to analyze the impact of MR on SLN status, disease-free survival (DFS), and overall survival...
February 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/27807664/intercellular-crosstalk-in-human-malignant-melanoma
#12
REVIEW
Barbora Dvořánková, Pavol Szabo, Ondřej Kodet, Hynek Strnad, Michal Kolář, Lukáš Lacina, Eliška Krejčí, Ondřej Naňka, Aleksi Šedo, Karel Smetana
Incidence of malignant melanoma is increasing globally. While the initial stages of tumors can be easily treated by a simple surgery, the therapy of advanced stages is rather limited. Melanoma cells spread rapidly through the body of a patient to form multiple metastases. Consequently, the survival rate is poor. Therefore, emphasis in melanoma research is given on early diagnosis and development of novel and more potent therapeutic options. The malignant melanoma is arising from melanocytes, cells protecting mitotically active keratinocytes against damage caused by UV light irradiation...
November 3, 2016: Protoplasma
https://www.readbyqxmd.com/read/27778319/histological-lymphovascular-invasion-is-associated-with-nodal-involvement-recurrence-and-survival-in-patients-with-cutaneous-malignant-melanoma
#13
Faruk Tas, Kayhan Erturk
BACKGROUND: Invasion of the lymphatic or vascular vessels by the primary tumor is considered a sign of aggressive disease that leads to metastases to the regional lymph nodes and to distant sites. Although lymphovascular invasion (LVI) is one of the major characteristics of a primary melanoma tumor, its prognostic significance remains controversial. OBJECTIVE: The objective of this study was to determine the clinical significance of LVI in melanoma patients. METHODS: Outcomes in 705 patients with cutaneous melanoma were investigated retrospectively...
October 25, 2016: International Journal of Dermatology
https://www.readbyqxmd.com/read/27775232/sentinel-lymph-node-biopsy-for-ocular-adnexal-melanoma
#14
Margaret L Pfeiffer, Omar K Ozgur, Jeffrey N Myers, Andrew Peng, Jing Ning, Mark E Zafereo, Sudip Thakar, Bradley Thuro, Victor G Prieto, Merrick I Ross, Bita Esmaeli
BACKGROUND: We sought to update our prior report of findings on sentinel lymph node biopsy (SLNB) and predictors of a positive SLN in patients with conjunctival or eyelid melanoma. METHODS: We reviewed the records of all patients with ocular adnexal melanoma who underwent SLNB at one institution during 2000-2015. We determined rates of positive and false-negative findings on SLNB, primary tumour features correlated with positive findings and rate of nodal recurrence (false-negative event) after negative findings...
October 24, 2016: Acta Ophthalmologica
https://www.readbyqxmd.com/read/27766186/prediction-of-positron-emission-tomography-computed-tomography-pet-ct-positivity-in-patients-with-high-risk-primary-melanoma
#15
Maria Danielsen, Andreas Kjaer, Max Wu, Lea Martineau, Mehdi Nosrati, Stanley Pl Leong, Richard W Sagebiel, James R Miller Iii, Mohammed Kashani-Sabet
Positron emission tomography/computed tomography (PET/CT) is an important tool to identify occult melanoma metastasis. To date, it is controversial which patients with primary cutaneous melanoma should have staging PET/CT. In this retrospective analysis of more than 800 consecutive patients with cutaneous melanoma, we sought to identify factors predictive of PET/CT positivity in the setting of newly-diagnosed high-risk primary melanoma to determine those patients most appropriate to undergo a PET/CT scan as part of their diagnostic work up...
2016: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27713424/5-hydroxymethylcytosine-is-an-independent-predictor-of-survival-in-malignant-melanoma
#16
Gerald Saldanha, Kushal Joshi, Kathryn Lawes, Mark Bamford, Farhaan Moosa, Kah Wee Teo, J Howard Pringle
Outcomes for melanoma patients vary within cancer stage. Prognostic biomarkers are potential adjuncts to provide more precise prognostic information. Simple, low-cost biomarker assays, such as those based on immunohistochemistry, have strong translational potential. 5-hydroxymethylcytosine (5 hmC) shows prognostic potential in melanoma but prior studies were small. We, therefore, analysed 5 hmC in a retrospective cohort to provide external validation of its prognostic value. Two hundred primary melanomas were evaluated for 5 hmC expression using immunohistochemistry...
October 7, 2016: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/27709599/cathepsin-k-expression-in-melanoma-is-associated-with-metastases
#17
Slavica Juric Petricevic, Antonia Pavlovic, Vesna Capkun, Kristijan Becic, Merica Glavina Durdov
Introduction Melanoma of the skin shows a tendency to metastasize via lymph or blood secreting matrix metalloproteinases and cathepsins, which enable penetration through the dermis. Cathepsin K acts in cytoplasm of atypical melanocytes and completely cleaves internalized collagen. Materials and methods Expression of cathepsin K was analyzed immunohistochemically in 45 melanomas and correlated to morphological and clinical parameters. Results During six years follow up, 13 patients developed lymph node metastases and three of them distant metastases...
October 6, 2016: Histology and Histopathology
https://www.readbyqxmd.com/read/27706081/golgi-related-proteins-golph2-gp73-golm1-and-golph3-gopp1-midas-in-cutaneous-melanoma-patterns-of-expression-and-prognostic-significance
#18
Piotr Donizy, Maciej Kaczorowski, Przemyslaw Biecek, Agnieszka Halon, Teresa Szkudlarek, Rafal Matkowski
GOLPH2 and GOLPH3 are Golgi-related proteins associated with aggressiveness and progression of a number of cancers. Their prognostic significance in melanoma has not yet been analyzed. We performed immunohistochemical analysis for GOLPH2 and GOLPH3 in 20 normal skin, 30 benign nevi and 100 primary melanoma tissue samples and evaluated their expression in three compartments: cancer cells, tumor-associated macrophages (TAMs) and cancer-associated fibroblasts (CAFs). High levels of both proteins in melanoma cells were associated with characteristics of aggressive disease, and shorter disease-free survival (DFS) and cancer-specific overall survival (CSOS)...
October 1, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27607033/mitotic-rate-in-primary-melanoma-interobserver-and-intraobserver-reliability-analyzed-using-h-e-sections-and-immunohistochemistry
#19
Claus Garbe, Thomas K Eigentler, Jürgen Bauer, Norbert Blödorn-Schlicht, Lorenzo Cerroni, Falko Fend, Markus Hantschke, Peter Kurschat, Heinz Kutzner, Dieter Metze, Volker Mielke, Harald Preßler, Michael Reusch, Ursula Reusch, Rudolf Stadler, Michael Tronnier, Amir Yazdi, Gisela Metzler
BACKGROUND: In 2009, the AJCC issued a revised melanoma staging system. In addition to tumor thickness and ulceration, the mitotic rate was introduced as the third major prognostic parameter for the classification of primary cutaneous melanoma. Given that, according to the 2009 AJCC classification, the detection of one or more dermal tumor mitoses leads to an upstaging - from stage Ia to Ib - of melanomas with a tumor thickness of ≤ 1.0 mm, we set out to investigate the reproducibility of this new parameter...
September 2016: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/27602146/an-observational-study-regarding-the-rate-of-growth-in-vertical-and-radial-growth-phase-superficial-spreading-melanomas
#20
Roberto Betti, Elena Agape, Raffaella Vergani, Laura Moneghini, Amilcare Cerri
The natural history of superficial spreading melanomas (SSMs) involves the progression from a radial growth phase (RGP) to a vertical growth phase (VGP). Currently, a patient's history represents the only method to estimate the rate of tumor growth. The present study aimed to verify whether the estimated rate of growth (ROG) of SSMs with a RGP or VGP exhibited any differences, and to evaluate the possible implications for the most important prognostic determinants. ROG was quantified as the ratio between Breslow's thickness in millimeters (mm) and the time of tumor growth in months, defined as the time between the date that the patient had first noticed the lesion in which melanoma subsequently developed and the date on which the patient first felt this lesion changed...
September 2016: Oncology Letters
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