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Mitotic rate and melanoma

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https://www.readbyqxmd.com/read/29028110/melanoma-staging-evidence-based-changes-in-the-american-joint-committee-on-cancer-eighth-edition-cancer-staging-manual
#1
Jeffrey E Gershenwald, Richard A Scolyer, Kenneth R Hess, Vernon K Sondak, Georgina V Long, Merrick I Ross, Alexander J Lazar, Mark B Faries, John M Kirkwood, Grant A McArthur, Lauren E Haydu, Alexander M M Eggermont, Keith T Flaherty, Charles M Balch, John F Thompson
Answer questions and earn CME/CNE To update the melanoma staging system of the American Joint Committee on Cancer (AJCC) a large database was assembled comprising >46,000 patients from 10 centers worldwide with stages I, II, and III melanoma diagnosed since 1998. Based on analyses of this new database, the existing seventh edition AJCC stage IV database, and contemporary clinical trial data, the AJCC Melanoma Expert Panel introduced several important changes to the Tumor, Nodes, Metastasis (TNM) classification and stage grouping criteria...
October 13, 2017: CA: a Cancer Journal for Clinicians
https://www.readbyqxmd.com/read/28958277/tumor-mitotic-rate-and-association-with-recurrence-in-sentinel-lymph-node-negative-stage-ii-melanoma-patients
#2
Shachar Laks, Michael O Meyers, Allison M Deal, Jill S Frank, Karyn B Stitzenberg, Jen Jen Yeh, Nancy E Thomas, David W Ollila
Tumor mitotic rate (TMR) is a known prognostic variable in thin melanoma patients. Its significance in stage II melanoma patients is yet to be demonstrated. Retrospective analysis of a prospective melanoma database from 9/1997 to 7/2015 was performed. All stage II melanoma, with documented TMR, and six months of follow-up were included. We evaluated the association of clinicopathologic variables, TMR, as a continuous and categorical variable with recurrence-free survival (RFS) and overall survival (OS) using Cox proportional hazards modeling...
September 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28944755/the-intriguing-effect-of-delay-time-to-sentinel-lymph-node-biopsy-on-survival-a-propensity-score-matching-study-on-a-cohort-of-melanoma-patients
#3
Antonio Tejera-Vaquerizo, Miguel Angel Descalzo-Gallego, Victor Traves, Celia Requena, Isidro Bolumar, Angel Pla, Eduardo Nagore
BACKGROUND: Time between primary melanoma excision and sentinel lymph node biopsy (SLNB) has not been sufficiently studied as an independent predictor of survival in cutaneous melanoma. OBJECTIVES: We used propensity score matching to evaluate whether early SLNB (performed ≤40 days from excisional biopsy) is associated with higher mortality in patients with cutaneous melanoma. MATERIALS & METHODS: A retrospective cohort study at a tertiary melanoma referral centre...
September 23, 2017: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/28881040/comprehensive-histopathologic-comparison-of-epidermotropic-dermal-metastatic-melanoma-and-primary-nodular-melanoma
#4
Stephanie L Skala, David P Arps, Lili Zhao, Kelly B Cha, Min Wang, Paul W Harms, Aleodor A Andea, Douglas R Fullen, May P Chan
AIMS: Metastatic melanoma involving the epidermis and/or upper dermis may show significant histologic overlap with primary cutaneous melanoma, especially the nodular subtype. Proper histopathologic classification is crucial to appropriate staging and management, yet often challenging. This study aims to identify helpful histopathologic features in differentiating epidermotropic/dermal metastatic melanoma (EDMM) and primary nodular melanoma (PNM). METHODS AND RESULTS: A cohort of EDMM (n=74) and PNM (n=75) was retrospectively reviewed for various histopathologic features, and the data were compared between groups by univariate analysis...
September 7, 2017: Histopathology
https://www.readbyqxmd.com/read/28871933/prognostic-predictors-of-thin-melanoma-in-clinico-pathological-practice
#5
Luca Roncati, Teresa Pusiol, Francesco Piscioli
The latest reviews on thin melanoma (TM) continue to consider it a melanoma within 1 mm in thickness, but no consensus exists as to which patients with TM are at risk for lymph node metastases (1). Numerous studies have evaluated the impact of various predictors (Breslow thickness, Clark level, ulceration, regression, vascular invasion, mitotic activity, location, sex) for nodal disease in melanoma, but the conclusions have not been homogenous (2,3). For this reason, we read the paper by Homolak et al. with great interest, where the authors examine the sentinel lymph node biopsies (SLNB) of 184 patients affected by melanoma of thickness less than 1...
July 2017: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/28851416/interim-analysis-of-survival-in-a-prospective-multi-center-registry-cohort-of-cutaneous-melanoma-tested-with-a-prognostic-31-gene-expression-profile-test
#6
Eddy C Hsueh, James R DeBloom, Jonathan Lee, Jeffrey J Sussman, Kyle R Covington, Brooke Middlebrook, Clare Johnson, Robert W Cook, Craig L Slingluff, Kelly M McMasters
BACKGROUND: A 31-gene expression profile (GEP) test that provides risk classification of cutaneous melanoma (CM) patients has been validated in several retrospective studies. The objective of the reported study was a prospective evaluation of the GEP performance in patients enrolled in two clinical registries. METHODS: Three-hundred twenty two CM patients enrolled in the EXPAND (NCT02355587) and INTEGRATE (NCT02355574) registries met the criteria of age ≥ 16 years, successful GEP result and ≥1 follow-up visit for inclusion in this interim analysis...
August 29, 2017: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/28842323/associations-of-statins-and-diabetes-with-diagnosis-of-ulcerated-cutaneous-melanoma
#7
Lena A von Schuckmann, David Smith, Maria Celia B Hughes, Maryrose Malt, Jolieke C van der Pols, Kiarash Khosrotehrani, Bernard M Smithers, Adele C Green
Ulcerated primary melanomas are associated with an inflammatory tumor micro-environment. We hypothesised that systemic pro-inflammatory states and anti-inflammatory medications are also associated with a diagnosis of ulcerated melanoma. In a cross-sectional study of 787 patients with newly-diagnosed clinical stage IB or II melanoma, we estimated odds ratios (ORs) for the association of pro-inflammatory factors (high body mass index (BMI), diabetes, cardiovascular disease, hypertension and smoking) or use of anti-inflammatory medications (statins, aspirin, corticosteroids and non-steroidal anti-inflammatory drugs), with ulcerated primary melanoma using regression models and subgroup analyses to control for melanoma thickness and mitotic rate...
August 22, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28750139/is-mitotic-rate-still-useful-in-the-management-of-patients-with-thin-melanoma
#8
A Tejera-Vaquerizo, G Pérez-Cabello, L Marínez-Leborans, E Gallego, V Oliver-Martínez, P Martín-Cuevas, S Arias-Santiago, J Aneiros-Fernández, E Herrera-Acosta, V Traves, E Herrera-Ceballos, E Nagore
BACKGROUND: T1 melanoma substaging was recently modified by the American Joint Committee on Cancer (AJCC). Although sentinel lymph node (SLN) positivity is the most important prognostic factor in melanoma, there is a lack of consensus on whether SLN biopsy should be performed in patients with thin melanoma (≤1 mm). OBJECTIVE: The main aim of this study was to investigate predictors of SLN positivity in patients with thin melanoma, with a special emphasis on mitotic rate...
July 27, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28715140/the-natural-history-of-thin-melanoma-and-the-utility-of-sentinel-lymph-node-biopsy
#9
Alison B Durham, Jennifer L Schwartz, Lori Lowe, Lili Zhao, Andrew G Johnson, Kelly L Harms, Christopher K Bichakjian, Amy P Orsini, Scott A McLean, Carol R Bradford, Mark S Cohen, Timothy M Johnson, Michael S Sabel, Sandra L Wong
BACKGROUND AND OBJECTIVES: Current literature may overestimate the risk of nodal metastasis from thin melanoma due to reporting of data only from lesions treated with SLNB. Our objective was to define the natural history of thin melanoma, assessing the likelihood of nodal disease, in order to guide selection for SLNB. METHODS: Retrospective review. The primary outcome was the rate of nodal disease. Clinicopathologic factors were evaluated to find associations with nodal disease...
July 17, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28657121/differential-ube2c-and-hoxa1-expression-in-melanocytic-nevi-and-melanoma
#10
Stefan Kraft, Johanna B Moore, Alona Muzikansky, Kenneth L Scott, Lyn M Duncan
BACKGROUND: Recent molecular advances suggest that Spitz nevi and other spitzoid neoplasms are biologically distinct from melanoma and conventional nevi. The ubiquitin ligase UBE2C and the homeobox transcription factor HOXA1 are candidate oncogenes in melanoma. METHODS: Using RNA expression analysis and immunohistochemistry, we evaluated these biomarkers in Spitz nevi (n = 20), melanoma (n = 20), and by immunohistochemistry in conventional nevi (n = 20)...
June 28, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28626898/polo-like-kinase-1-immunoreactivity-is-associated-with-metastases-in-cutaneous-melanoma
#11
Maciej Kaczorowski, Tomasz Borowiec, Piotr Donizy, Konrad Pagacz, Wojciech Fendler, Artur Lipinski, Agnieszka Halon, Rafal Matkowski
BACKGROUND: Polo-like kinase-1 (PLK-1) is one of the key regulators of cell cycle progression. Increased expression of PLK-1 was observed in several tumor types. METHODS: We immunohistochemically assessed PLK-1 expression in neoplastic and stromal compartments of 96 cutaneous melanomas, and analyzed associations between PLK-1 expression and clinicopathological characteristics. RESULTS: PLK-1 expression in cancer cells was not associated with basic clinical (eg, age, gender and tumor location) or histopathological (eg, Breslow thickness, mitotic rate and ulceration) parameters...
June 19, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28609344/phosphohistone-h3-and-ki67-useful-markers-in-differentiating-dermatofibroma-from-dermatofibrosarcoma-protuberans-and-atypical-fibrohistiocytic-lesions
#12
Atin Agarwal, Arun Gopinath, Michael T Tetzlaff, Victor G Prieto
Dermatofibromas (DF) are common, benign, skin tumors, usually easily differentiated from dermatofibrosarcoma protuberans (DFSP) by the presence of a relative low cellularity, lesser degree of infiltration of subcutaneous tissue, and immunohistochemical pattern (eg, FXIIIa in DF and CD34 in DFSP). Atypical fibrohistiocytic lesions (AFL) have features intermediate to DF and DFSP (trunk location, storiform pattern, infiltration of the subcutaneous tissue, and focal expression of both CD34 and Factor XIIIa). It is unclear if mitotic counts/degree of proliferation is helpful to distinguish DF from DFSP...
July 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28574851/crgd-installed-docetaxel-loaded-mertansine-prodrug-micelles-redox-triggered-ratiometric-dual-drug-release-and-targeted-synergistic-treatment-of-b16f10-melanoma
#13
Ping Zhong, Min Qiu, Jian Zhang, Huanli Sun, Ru Cheng, Chao Deng, Fenghua Meng, Zhiyuan Zhong
The combinatorial chemotherapy that has emerged as a promising treatment modality for intractable cancers is challenged by lack of tumor-targeting, robust and ratiometric dual drug release systems. Here, docetaxel-loaded cRGD peptide-decorated redox-activable micellar mertansine prodrug (DTX-cRGD-MMP) was developed for targeted and synergistic treatment of B16F10 melanoma-bearing C57BL/6 mice. DTX-cRGD-MMP exhibited a small size of ca. 49 nm, high DTX and DM1 loading, low drug leakage under physiological conditions, while rapid release of both DTX and DM1 under a cytoplasmic reductive environment...
June 2, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28555886/lymphatic-invasion-predicts-sentinel-lymph-node-metastasis-and-adverse-outcome-in-primary-cutaneous-melanoma
#14
Andrea P Moy, Mark C Mochel, Alona Muzikansky, Lyn M Duncan, Stefan Kraft
BACKGROUND: Sentinel lymph node (SLN) metastasis is a powerful predictor of survival in primary cutaneous melanoma. Lymphatic invasion (LI) may correlate with increased risk of SLN metastasis. Intralymphatic metastases, often difficult to detect on hematoxylin and eosin (H&E) stained sections, are readily identified with dual immunohistochemistry for melanocytic and lymphatic markers. METHODS: We used dual S100/D240 immunohistochemistry to detect LI in 125 melanomas from patients who underwent SLN biopsy and correlated LI with melanoma staging parameters and disease status...
May 29, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28543798/mucosal-melanoma-clinical-histological-and-c-kit-gene-mutational-profile-of-86-french-cases
#15
E Cinotti, J Chevallier, B Labeille, F Cambazard, L Thomas, B Balme, M T Leccia, M D'Incan, P Vercherin, C Douchet, P Rubegni, J L Perrot
BACKGROUND: Mucosal melanomas are rare and highly aggressive tumors. Few studies evaluated mucosal melanomas of locations other than the head and neck region, and other than those of the Asian population. OBJECTIVES: The objective of this study was to analyze the clinical and histological features, as well as the mutational status of c-kit and b-raf gene of mucosal melanoma in any localization in a French series. METHODS: We investigated clinical (sex, age, performance status, survival, treatment of the patients and lack of pigmentation of the tumors) and histopathologic features (ulceration, Breslow's index, mitotic rate), as well as the mutational status of c-kit and b-raf of 86 mucosal melanomas diagnosed in 15 years in four French University Hospitals...
May 22, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28467693/expression-of-g-protein-coupled-oestrogen-receptor-in-melanoma-and-in-pregnancy-associated-melanoma
#16
M Fábián, F Rencz, T Krenács, V Brodszky, J Hársing, K Németh, P Balogh, S Kárpáti
BACKGROUND: The hormone sensitivity of melanoma and the role of 'classical' oestrogen receptor (ER) α and β in tumour progression have been intensively studied with rather contradictory results. The presence of 'non-classical' G protein-coupled oestrogen receptor (GPER) has not been investigated on human melanoma tissues. OBJECTIVE: To analyse the expression of GPER, ERα and ERβ in pregnancy-associated (PAM) and in non-pregnancy-associated (NPAM) melanomas in correlation with traditional prognostic markers and disease-free survival (DFS)...
May 3, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28443572/primary-sinonasal-malignant-melanoma-effect-of-clinical-and-histopathologic-prognostic-factors-on-survival
#17
Sercan Göde, Göksel Turhal, Ceyda Tarhan, Banu Yaman, Gülşen Kandiloğlu, Kerem Öztürk, İsa Kaya, Raşit Midilli, Bülent Karcı
BACKGROUND: Mucosal melanoma is a rare malignancy arising from melanocytes of the mucosal surfaces. The pattern and frequency of oncogenic mutations and histopathological biomarkers have a role on distinct tumour behaviour and survival. AIMS: To assess the rate of C-KIT positivity and its effect on survival of surgically treated sinonasal malignant melanoma patients with other histopathological biomarkers and clinical features. STUDY DESIGN: Retrospective cross-sectional study...
May 5, 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/28424234/braf-v600-mutation-detection-in-melanoma-a-comparison-of-two-laboratory-testing-methods
#18
Odharnaith O'Brien, Tomas Lyons, Sandra Murphy, Linda Feeley, Derek Power, Cynthia C B B Heffron
AIMS: The assessment of B-raf proto-oncogene, serine/threonine kinase (BRAF) gene status is now standard practice in patients diagnosed with metastatic melanoma with its presence predicting a clinical response to treatment with BRAF inhibitors. The gold standard in determining BRAF status is currently by DNA-based methods. More recently, a BRAF V600E antibody has been developed. We aim to investigate whether immunohistochemical detection of BRAF mutation is a suitable alternative to molecular testing by polymerase chain reaction (PCR)...
April 19, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28399177/dermoscopic-characteristics-of-melanoma-according-to-the-criteria-ulceration-and-mitotic-rate-of-the-ajcc-2009-staging-system-for-melanoma
#19
Teresa Deinlein, Edith Arzberger, Iris Zalaudek, Cesare Massone, Juan Garcias-Ladaria, André Oliveira, Günter Schulter, Rainer Hofmann-Wellenhof
OBJECTIVE: The present study was conducted to identify possible dermoscopic patterns, associated with mitotic rate > 1/mm2, histological ulceration in melanoma and metastatic disease. METHODS: For this retrospective data analysis all clinical and dermoscopic digital images of primary malignant melanomas between 2008 and 2013 documented at the Department of Dermatology Graz were included, using the internal image data-base. 550 patients with 559 melanomas were included...
2017: PloS One
https://www.readbyqxmd.com/read/28368925/a-novel-numerical-scoring-system-for-melanoma-tumor-infiltrating-lymphocytes-has-better-prognostic-value-than-standard-scoring
#20
Gerald Saldanha, Katarina Flatman, Kah Wee Teo, Mark Bamford
The purpose of this study was to evaluate the prognostic value of tumor-infiltrating lymphocytes (TILs) in melanoma and to determine whether a simpler numerical scoring system would be more effective. In total, 655 patients presenting to a UK teaching hospital with primary invasive melanoma were analyzed. TILs were rescored using the standard Clark's method and univariable and multivariable analyses of the effect of TILs on overall survival (OS), disease-specific survival (DSS), and metastasis-free survival (MFS) was assessed using Cox regression...
July 2017: American Journal of Surgical Pathology
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