Raymond Barnhill, Steven van Laere, Peter Vermeulen, Sergio Roman-Roman, Sophie Gardrat, Samar Alsafadi, Malcy Tarin, Gabriel Champenois, André Nicolas, Alexandre Matet, Nathalie Cassoux, Vincent Servois, Manuel Rodrigues, Richard Scolyer, Alexander Lazar, Emanuela Romano, Sophie Piperno-Neumann, Pascale Mariani, Claire Lugassy
The replacement histopathologic growth pattern (rHGP) in melanoma liver metastases connotes an aggressive phenotype (vascular co-option; angiotropic extravascular migratory spread) and adverse prognosis. Herein, replacement and desmoplastic HGP (dHGP) were studied in uveal melanoma liver metastases (MUM). In particular, L1CAM and a "laminin vascular network" were detected at the advancing front of 14/20 cases (p = 0.014) and 16/20 cases (p = 6.4e-05) rHGPs, respectively, but both were absent in the dHGP (8/8 cases) (p = 0...
November 2022: Laboratory Investigation; a Journal of Technical Methods and Pathology