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https://www.readbyqxmd.com/read/27770854/effectiveness-of-intracavernous-delivery-of-recombinant-human-hepatocyte-growth-factor-on-erectile-function-in-the-streptozotocin-induced-diabetic-mouse
#1
Nando Dulal Das, Guo Nan Yin, Min Ji Choi, Kang-Moon Song, Jin-Mi Park, Anita Limanjaya, Kalyan Ghatak, Nguyen Nhat Minh, Jiyeon Ock, Soo-Hwan Park, Ho Min Kim, Ji-Kan Ryu, Jun-Kyu Suh
INTRODUCTION: Diabetic erectile dysfunction is a disease mostly of vascular origin and men with diabetic erectile dysfunction respond poorly to oral phosphodiesterase-5 inhibitors. Hepatocyte growth factor (HGF) is a pleiotropic factor that plays an essential role in the regulation of cell proliferation, survival, and angiogenesis. AIM: To determine the effectiveness of recombinant human (rh)-HGF in restoring erectile function in diabetic mice. METHODS: Four groups of mice were used: control non-diabetic mice and streptozotocin-induced diabetic mice receiving two successive intracavernous injections of phosphate buffered saline (days -3 and 0), a single intracavernous injection of rh-HGF (day 0), or two successive intracavernous injections of rh-HGF (days -3 and 0)...
November 2016: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/27746269/genetic-instability-cpg-island-methylator-phenotype-and-proliferative-activity-are-distinct-differences-between-diminutive-and-small-tubular-adenoma-of-the-colorectum
#2
Yoshiki Nando, Jiro Watari, Chiyomi Ito, Ken Hara, Takahisa Yamasaki, Takuya Okugawa, Takashi Kondo, Tomoaki Kono, Katsuyuki Tozawa, Toshihiko Tomita, Yoshio Ohda, Tadayuki Oshima, Hirokazu Fukui, Nagahide Matsubara, Naohiro Tomita, Seiichi Hirota, Hiroto Miwa
It is recommended that small (6-10 mm) lesions be treated with endoscopic resection (ER), while diminutive (≤ 5 mm) lesions are not currently an indication for ER according to the Japanese guidelines. The aim of this study was to evaluate the molecular alterations, and therefore treatment indications, in diminutive vs. small tubular adenoma (TA). We prospectively analyzed genetic instability, including microsatellite instability (MSI) and loss of heterozygosity, methylation status, KRAS/BRAF mutations, and Ki-67 staining in 96 TAs without a villous component...
October 13, 2016: Human Pathology
https://www.readbyqxmd.com/read/27369868/the-outcome-of-treatment-of-chronic-osteomyelitis-according-to-an-integrated-approach
#3
Leonard C Marais, Nando Ferreira, Colleen Aldous, Theo L B Le Roux
Previous classification systems of chronic osteomyelitis have failed to provide objective and pragmatic guidelines for selection of the appropriate treatment strategy. In this study, we assessed the short-term treatment outcome in adult patients with long-bone chronic osteomyelitis prospectively where a modified host classification system was integrated with treatment strategy selection through a novel management algorithm. Twenty-six of the 28 enrolled patients were available for follow-up at a minimum of 12 months...
August 2016: Strategies in Trauma and Limb Reconstruction
https://www.readbyqxmd.com/read/27344426/two-stage-reconstruction-of-septic-non-union-of-the-humerus-with-the-use-of-circular-external-fixation
#4
Nando Ferreira, Leonard Charles Marais, Charles Serfontein
Achieving quiescence in chronic osteomyelitis remains challenging. Wide resection of all infected and necrotic tissues improves the chances of achieving remission of the disease. Extensive debridement however decreases the already compromised bone stock that increases the complexity of reconstruction. We report on the outcome of eight patients with Cierny and Mader stage IV chronic osteomyelitis of the humerus who underwent debridement followed by bone graft and circular fixator application as a second stage procedure...
August 2016: Injury
https://www.readbyqxmd.com/read/27047221/mechanobiology-in-the-management-of-mobile-atrophic-and-oligotrophic-tibial-nonunions
#5
Nando Ferreira, Leonard Charles Marais, Colleen Aldous
BACKGROUND: Recent research indicates that atrophic nonunions are biologically active and may heal in the optimal biomechanical environment. METHODS: Thirty-three patients with mobile atrophic and oligotrophic tibial nonunions were treated with circular external fixation and functional rehabilitation. Seven patients required autogenous bone graft procedures. RESULTS: Bony union was achieved after the initial surgery in 31/33 (93.9%) tibias...
December 2015: Journal of Orthopaedics
https://www.readbyqxmd.com/read/26799576/on-demand-guided-bone-regeneration-with-microbial-protection-of-ornamented-spu-scaffold-with-bismuth-doped-single-crystalline-hydroxyapatite-augmentation-and-cartilage-formation
#6
M Selvakumar, Priyanka Srivastava, Harpreet Singh Pawar, Nimmy K Francis, Bodhisatwa Das, G Sathishkumar, Bhuvaneshwaran Subramanian, Saravana Kumar Jaganathan, Gibin George, S Anandhan, Santanu Dhara, Golok B Nando, Santanu Chattopadhyay
Guided bone regeneration (GBR) scaffolds are futile in many clinical applications due to infection problems. In this work, we fabricated GBR with an anti-infective scaffold by ornamenting 2D single crystalline bismuth-doped nanohydroxyapatite (Bi-nHA) rods onto segmented polyurethane (SPU). Bi-nHA with high aspect ratio was prepared without any templates. Subsequently, it was introduced into an unprecedented synthesized SPU matrix based on dual soft segments (PCL-b-PDMS) of poly(ε-caprolactone) (PCL) and poly(dimethylsiloxane) (PDMS), by an in situ technique followed by electrospinning to fabricate scaffolds...
February 17, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/26653855/fcp1-phosphatase-controls-greatwall-kinase-to-promote-pp2a-b55-activation-and-mitotic-progression
#7
Rosa Della Monica, Roberta Visconti, Nando Cervone, Angela Flavia Serpico, Domenico Grieco
During cell division, progression through mitosis is driven by a protein phosphorylation wave. This wave namely depends on an activation-inactivation cycle of cyclin B-dependent kinase (Cdk) 1 while activities of major protein phosphatases, like PP1 and PP2A, appear directly or indirectly repressed by Cdk1. However, how Cdk1 inactivation is coordinated with reactivation of major phosphatases at mitosis exit still lacks substantial knowledge. We show here that activation of PP2A-B55, a major mitosis exit phosphatase, required the phosphatase Fcp1 downstream Cdk1 inactivation in human cells...
2015: ELife
https://www.readbyqxmd.com/read/26587373/pre-treatment-serum-lactate-dehydrogenase-and-alkaline-phosphatase-as-predictors-of-metastases-in-extremity-osteosarcoma
#8
Leonard C Marais, Julia Bertie, Reitze Rodseth, Benn Sartorius, Nando Ferreira
BACKGROUND: The prognosis of patients with metastatic osteosarcoma remains poor. However, the chance of survival can be improved by surgical resection of all metastases. In this study we investigate the value of serum alkaline phosphatase (ALP) and lactate dehydrogenase (LDH) in predicting the presence of metastatic disease at time of diagnosis. METHODS: Sixty-one patients with histologically confirmed conventional osteosarcoma of the extremity were included in the study...
September 2015: Journal of Bone Oncology
https://www.readbyqxmd.com/read/26582142/dual-transcriptome-sequencing-reveals-resistance-of-tlr4-ligand-activated-bone-marrow-derived-macrophages-to-inflammation-mediated-by-the-bet-inhibitor-jq1
#9
Amitabh Das, Jin Choul Chai, Chul-Su Yang, Young Seek Lee, Nando Dulal Das, Kyoung Hwa Jung, Young Gyu Chai
Persistent macrophage activation is associated with the expression of various pro-inflammatory genes, cytokines and chemokines, which may initiate or amplify inflammatory disorders. A novel synthetic BET inhibitor, JQ1, was proven to exert immunosuppressive activities in macrophages. However, a genome-wide search for JQ1 molecular targets has not been undertaken. The present study aimed at evaluating the anti-inflammatory function and underlying genes that are targeted by JQ1 in LPS-stimulated primary bone marrow-derived macrophages (BMDMs) using global transcriptomic RNA sequencing and quantitative real-time PCR...
2015: Scientific Reports
https://www.readbyqxmd.com/read/26566317/a-modified-staging-system-for-chronic-osteomyelitis
#10
Leonard Charles Marais, Nando Ferreira, Colleen Aldous, Benn Sartorius, Theo Le Roux
AIMS: To investigate the short-term outcome of treatment of chronic osteomyelitis where management was based on a refined host stratification system. METHODS: A retrospective review of 109 adult patients with chronic osteomyelitis. RESULTS: At a minimum follow-up of 12 months (range 12-36) we observed an overall success rate of 89.9% (95% CI: 82.7-94.9%). There was no statistically significant difference in success rates by host status (p-value = 0...
December 2015: Journal of Orthopaedics
https://www.readbyqxmd.com/read/26492881/management-of-tibial-non-unions-according-to-a-novel-treatment-algorithm
#11
Nando Ferreira, Leonard Charles Marais
Tibial non-unions represent a spectrum of conditions that are challenging to treat. The optimal management remains unclear despite the frequency with which these diagnoses are encountered. The aim of this study was to determine the outcome of tibial non-unions managed according to a novel tibial non-union treatment algorithm. One hundred and eighteen consecutive patients with 122 uninfected tibial non-unions were treated according to our proposed tibial non-union treatment algorithm. All patients were followed-up clinically and radiologically for a minimum of six months after external fixator removal...
December 2015: Injury
https://www.readbyqxmd.com/read/26349305/synthesis-and-characterization-of-novel-polycarbonate-based-polyurethane-polymer-wrapped-hydroxyapatite-nanocomposites-mechanical-properties-osteoconductivity-and-biocompatibility
#12
M Selvakumar, Saravana Kumar Jaganathan, Golok B Nando, Santanu Chattopadhyay
The present investigation reports the preparation of two types of 2D rod-like nano-hydroxyapatite (nHA) (unmodified and Polypropylene glycol (PPG) wrapped) of varying high-aspect ratios, by modified co-precipitation methods, without any templates. These nHA were successfully introduced into novel synthesized Thermoplastic Polyurethane (TPU) matrices based on polycarbonate soft segments, by both in-situ and ex-situ techniques. Physico-mechanical properties of the in-situ prepared TPU/nHA nanocomposites were found to be superior compared to the ex-situ counterparts, and pristine nHA reinforced TPU...
February 2015: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/26329761/medical-teleconsultation-to-general-practitioners-reduces-the-medical-error-vulnerability-of-internal-medicine-patients
#13
Nando Campanella, Pierpaolo Morosini, Guido Sampaolo, Vania Catozzo, Andrea Caso, Maurizio Ferretti, Moreno Giovagnoli, Mariangela Torniai, Ettore Antico
BACKGROUND: e-Health strategies are supposed to improve the performance of national health systems. Medical teleconsultation (MT) is an important component of such e-Health strategies. OBJECTIVES: The outcome of MT was evaluated with regard to the impact on the medical error vulnerability (MEV) of internal medicine patients. METHODS: A team of internal medicine doctors plus a network of forty specialists was set-up in one health district belonging to a unified and universal national health system of a country of Western Europe, in order to provide free-of-charge MT to support general practitioners in solving internal medicine cases...
November 2015: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/26044953/the-pericyte-as-a-cellular-regulator-of-penile-erection-and-a-novel-therapeutic-target-for-erectile-dysfunction
#14
Guo Nan Yin, Nando Dulal Das, Min Ji Choi, Kang-Moon Song, Mi-Hye Kwon, Jiyeon Ock, Anita Limanjaya, Kalyan Ghatak, Woo Jean Kim, Jae Seog Hyun, Gou Young Koh, Ji-Kan Ryu, Jun-Kyu Suh
Pericytes are known to play critical roles in vascular development and homeostasis. However, the distribution of cavernous pericytes and their roles in penile erection is unclear. Herein we report that the pericytes are abundantly distributed in microvessels of the subtunical area and dorsal nerve bundle of mice, followed by dorsal vein and cavernous sinusoids. We further confirmed the presence of pericytes in human corpus cavernosum tissue and successfully isolated pericytes from mouse penis. Cavernous pericyte contents from diabetic mice and tube formation of cultured pericytes in high glucose condition were greatly reduced compared with those in normal conditions...
2015: Scientific Reports
https://www.readbyqxmd.com/read/26005575/complications-corner-anterior-thoracic-disc-surgery-with-dural-tear-csf-fistula-and-low-pressure-pleural-drain-led-to-severe-intracranial-hypotension
#15
Eline A Oudeman, Rishi D S Nandoe Tewarie, G Joost Jöbsis, Mark P Arts, Nyika D Kruyt
BACKGROUND: Thoracic disc surgery can lead to a life-threatening complication: intracranial hypotension due to a subarachnoid-pleural fistula. CASE DESCRIPTION: We report a 63-year-old male with paraparesis due to multiple herniated thoracic discs, with compressive myelopathy. The patient required a circumferential procedure including a laminectomy/fusion followed by an anterior thoracic decompression to address both diffuse idiopathic skeletal hyperostosis (DISH) anteriorly and posterior stenosis...
2015: Surgical Neurology International
https://www.readbyqxmd.com/read/25840909/bone-transport-through-an-induced-membrane-in-the-management-of-tibial-bone-defects-resulting-from-chronic-osteomyelitis
#16
Leonard Charles Marais, Nando Ferreira
Wide resection of infected bone improves the odds of achieving remission of infection in patients with chronic osteomyelitis. Aggressive debridement is followed by the creation of large bone defects. The use of antibiotic-impregnated PMMA spacers, as a customized dead space management tool, has grown in popularity. In addition to certain biological advantages, the spacer offers a therapeutic benefit by serving as a vehicle for delivery of local adjuvant antibiotics. In this study, we investigate the efficacy of physician-directed antibiotic-impregnated PMMA spacers in achieving remission of chronic tibial osteomyelitis...
April 2015: Strategies in Trauma and Limb Reconstruction
https://www.readbyqxmd.com/read/25786500/radiographic-analysis-of-hexapod-external-fixators-fundamental-differences-between-the-taylor-spatial-frame-and-truelok-hex
#17
Nando Ferreira, Franz Birkholtz
Hexapod circular external fixators are extremely accurate at correcting deformities in three dimensions. In order to exploit this accuracy, however, the surgeon must be able to accurately analyse the deformity and mounting parameters on post-operative radiographs. A Sawbone® model was created to simulate a mid-shaft tibial fracture with deformity. A 180 mm ring was applied oblique to the proximal segment of the Sawbone® model, in both the sagittal and coronal planes. Standard radiographs were taken of the model and analysed using the described Taylor Spatial Frame and TrueLok-Hex methods...
April 2015: Journal of Medical Engineering & Technology
https://www.readbyqxmd.com/read/25193078/jmjd2a-attenuation-affects-cell-cycle-and-tumourigenic-inflammatory-gene-regulation-in-lipopolysaccharide-stimulated-neuroectodermal-stem-cells
#18
Amitabh Das, Jin Choul Chai, Kyoung Hwa Jung, Nando Dulal Das, Sung Chul Kang, Young Seek Lee, Hyemyung Seo, Young Gyu Chai
JMJD2A is a lysine trimethyl-specific histone demethylase that is highly expressed in a variety of tumours. The role of JMJD2A in tumour progression remains unclear. The objectives of this study were to identify JMJD2A-regulated genes and understand the function of JMJD2A in p53-null neuroectodermal stem cells (p53(-/-) NE-4Cs). We determined the effect of LPS as a model of inflammation in p53(-/-) NE-4Cs and investigated whether the epigenetic modifier JMJD2A alter the expression of tumourigenic inflammatory genes...
November 1, 2014: Experimental Cell Research
https://www.readbyqxmd.com/read/25056512/the-effect-of-hiv-infection-on-the-incidence-and-severity-of-circular-external-fixator-pin-track-sepsis-a-retrospective-comparative-study-of-229-patients
#19
Nando Ferreira, Leonard Charles Marais
Pin track sepsis is a common complication of circular external fixation. HIV status has been implicated as an independent risk factor for the development of pin track infection and has been cited as a reason not to attempt complex limb reconstruction in HIV-positive patients. This retrospective review of patients treated with circular external fixators looked at the incidence of pin track sepsis in HIV-positive, HIV-negative and patients whose HIV status was unknown. The records of 229 patients, 40 of whom were HIV-positive, were reviewed...
August 2014: Strategies in Trauma and Limb Reconstruction
https://www.readbyqxmd.com/read/24979788/inhibition-of-ninjurin-1-restores-erectile-function-through-dual-angiogenic-and-neurotrophic-effects-in-the-diabetic-mouse
#20
Guo Nan Yin, Min Ji Choi, Woo Jean Kim, Mi-Hye Kwon, Kang-Moon Song, Jin-Mi Park, Nando Dulal Das, Ki-Dong Kwon, Dulguun Batbold, Goo Taeg Oh, Gou Young Koh, Kyu-Won Kim, Ji-Kan Ryu, Jun-Kyu Suh
Penile erection is a neurovascular phenomenon, and erectile dysfunction (ED) is caused mainly by vascular risk factors or diseases, neurologic abnormalities, and hormonal disturbances. Men with diabetic ED often have severe endothelial dysfunction and peripheral nerve damage, which result in poor response to oral phosphodiesterase-5 inhibitors. Nerve injury-induced protein 1 (Ninjurin 1, Ninj1) is known to be involved in neuroinflammatory processes and to be related to vascular regression during the embryonic period...
July 1, 2014: Proceedings of the National Academy of Sciences of the United States of America
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