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https://www.readbyqxmd.com/read/28090468/clinical-features-and-extraintestinal-manifestations-of-crohn-disease-in-children
#1
Young Ah Lee, Peter Chun, Eun Ha Hwang, Sang Wook Mun, Yeoun Joo Lee, Jae Hong Park
PURPOSE: The aim of this study was to investigate the clinical features and extraintestinal manifestations (EIMs) of Crohn disease (CD) in Korean pediatric patients. METHODS: The medical records of 73 children diagnosed with CD were retrospectively reviewed. Data regarding baseline demographic and clinical characteristics, including CD phenotype at diagnosis based on the Montreal classification, and clinical features and course of EIMs were investigated. RESULTS: Fifty-two (71...
December 2016: Pediatric Gastroenterology, Hepatology & Nutrition
https://www.readbyqxmd.com/read/28052082/crohn-s-disease-localization-displays-different-predisposing-genetic-variants
#2
Orazio Palmieri, Fabrizio Bossa, Maria Rosa Valvano, Giuseppe Corritore, Tiziana Latiano, Giuseppina Martino, Renata D'Incà, Salvatore Cucchiara, Maria Pastore, Mario D'Altilia, Daniela Scimeca, Giuseppe Biscaglia, Angelo Andriulli, Anna Latiano
BACKGROUND: Crohn's disease (CD) is a pathologic condition with different clinical expressions that may reflect an interplay between genetics and environmental factors. Recently, it has been highlighted that three genetic markers, NOD2, MHC and MST1, were associated to distinct CD sites, supporting the concept that genetic variations may contribute to localize CD. Genetic markers, previously shown to be associated with inflammatory bowel disease (IBD), were tested in CD patients with the aim to better dissect the genetic relationship between ileal, ileocolonic and colonic CD and ascertain whether a different genetic background would support the three disease sites as independent entities...
2017: PloS One
https://www.readbyqxmd.com/read/28050863/incremental-prognostic-value-of-spect-mpi-in-chronic-kidney-disease-a-reclassification-analysis
#3
Amjad M Ahmed, Waqas T Qureshi, Wesley T O'Neal, Fatima Khalid, Mouaz H Al-Mallah
BACKGROUND: Traditional cardiovascular (CV) risk factors have limited predictive value of CV mortality in patients with chronic kidney disease (CKD, creatinine clearance less than 60 mL/minute per 1.73 m(2)). The aim of this study was to evaluate incremental and independent prognostic value of single-photon emission computerized tomography-myocardial perfusion imaging (SPECT-MPI) across continuum of renal function. METHODS: We retrospectively studied 11,518 (mean age, 65 ± 12 years; 52% were men) patients referred for a clinical indication of SPECT-MPI between April 2004 and May 2009...
January 3, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28039809/selective-staining-of-cds-on-zno-biolabel-for-ultrasensitive-sandwich-type-amperometric-immunoassay-of-human-heart-type-fatty-acid-binding-protein-and-immunoglobulin-g
#4
Xiaoli Qin, Aigui Xu, Ling Liu, Yuyun Sui, Yunlong Li, Yueming Tan, Chao Chen, Qingji Xie
We report on an ultrasensitive metal-labeled amperometric immunoassay of proteins, which is based on the selective staining of nanocrystalline cadmium sulfide (CdS) on ZnO nanocrystals and in-situ microliter-droplet anodic stripping voltammetry (ASV) detection on the immunoelectrode. Briefly, antibody 1 (Ab1), bovine serum albumin (BSA), antigen and ZnO-multiwalled carbon nanotubes (MWCNTs) labeled antibody 2 (Ab2-ZnO-MWCNTs) were successively anchored on a β-cyclodextrin-graphene sheets (CD-GS) nanocomposite modified glassy carbon electrode (GCE), forming a sandwich-type immunoelectrode (Ab2-ZnO-MWCNTs/antigen/BSA/Ab1/CD-GS/GCE)...
December 22, 2016: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28039168/correlation-of-the-rutgeerts-score-and-recurrence-of-crohn-s-disease-in-patients-with-end-ileostomy
#5
Vasutakarn Chongthammakun, Andre Fialho, Andrea Fialho, Rocio Lopez, Bo Shen
BACKGROUND: Recurrence of Crohn's disease (CD) can occur after surgery, including end ileostomy (EI). The Rutgeerts score (RS) was developed to predict postsurgical CD recurrence via ileocolonoscopy in patients having ileocolonic resection. The role of ileoscopic evaluation via stoma for assessing recurrence of CD has not been investigated. The aim of this study was to evaluate the role of ileoscopy for predicting disease recurrence in CD patients after EI with the use of RS. METHODS: A total of 73 eligible CD patients with at least two ileoscopies in our institution following EI were included...
December 30, 2016: Gastroenterology Report
https://www.readbyqxmd.com/read/28025773/bone-mineral-density-in-celiac-disease
#6
Ganesh Choudhary, Raj Kumar Gupta, Jaiveer Beniwal
OBJECTIVES: To study bone mineral density (BMD) and standard serum biochemical indices among newly diagnosed and already diagnosed cases of Celiac Disease (CD) on gluten free diet for at least one year. METHODS: This hospital based analytic, observational study was done at a tertiary care centre, from April 2013 through June 2014. Thirty six children (20 females) with untreated CD at diagnosis (Group A) and 36 age and sex matched children on gluten-free diet for at least one year (Group B) were studied...
December 27, 2016: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/28012103/determinants-of-healthcare-utilization-among-veterans-with-inflammatory-bowel-disease
#7
Mimi C Tan, Hashem B El-Serag, Jason K Hou
BACKGROUND: Identifying patient-level and disease-specific predictors of healthcare utilization in inflammatory bowel disease (IBD) may allow targeted interventions to reduce costs and improve outcomes. AIM: To identify demographic and clinical predictors of healthcare utilization among veterans with IBD. METHODS: We conducted a single-center cross-sectional study of veterans with IBD from 1998 to 2010. Demographics and disease characteristics were abstracted by manual chart review...
December 23, 2016: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28009808/evaluation-of-the-treatment-process-of-landfill-leachate-using-the-toxicity-assessment-method
#8
Aifeng Qiu, Qiang Cai, Yuan Zhao, Yingqing Guo, Liqian Zhao
Landfill leachate is composed of a complex composition with strong biological toxicity. The combined treatment process of coagulation and sedimentation, anaerobics, electrolysis, and aerobics was set up to treat landfill leachate. This paper explores the effect of different operational parameters of coagulation and sedimentation tanks and electrolytic cells, while investigating the combined process for the removal efficiency of physicochemical indices after processing the landfill leachate. Meanwhile, a battery of toxicity tests with Vibrio fischeri, zebrafish larvae, and embryos were conducted to evaluate acute toxicity and calculated the toxicity reduction efficiency after each treatment process...
December 21, 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28002332/the-association-of-the-mthfr-c677t-polymorphism-with-inflammatory-bowel-diseases-in-the-israeli-jewish-population-an-example-of-genetic-heterogeneity
#9
Amir Karban, Tzah Feldman, Matti Waterman, Ronit Leiba, Edna Efrati
MTHFR C677T is a common gene polymorphism that has been shown to be associated with hyperhomocysteinemia. Studies on the role of MTHFR in inflammatory bowel diseases (IBD) have yielded conflicting results, perhaps due in part to genetic heterogeneity. The prevalence of the MTHFR C677T variant allele varies according to Jewish subpopulations: Ashkenazi vs non-Ashkenazi. The aim of this study was to examine the association between MTHFR C677T genotype and IBD in the different Jewish populations.DNA samples were assessed for the presence of the MTHFR C677T variant allele in 445 Jewish Israeli IBD patients: 338 with Crohn's disease [CD] (214 Ashkenazi and 124 non-Ashkenazi Jews) and 107 with ulcerative colitis [UC] (73 Ashkenazi and 34 non-Ashkenazi Jews), and in 347 healthy controls: 173 Ashkenazi and 174 Non-Ashkenazi Jews...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28002129/development-and-internal-validation-of-a-model-using-fecal-calprotectin-in-combination-with-infliximab-trough-levels-to-predict-clinical-relapse-in-crohn-s-disease
#10
Xavier Roblin, Gerard Duru, Nicolas Williet, Emilie Del Tedesco, Murielle Cuilleron, Camille Jarlot, Jean Marc Phelip, Gilles Boschetti, Bernard Flourié, Stephane Nancey, Laurent Peyrin-Biroulet, Stephane Paul
BACKGROUND: The best noninvasive method predicting clinical relapse remains undetermined in infliximab (IFX)-treated patients with Crohn's disease. METHODS: All patients with CD on IFX maintenance treatment and in clinical remission for at least 16 weeks, between 2011 and 2014, were enrolled in a prospective single-center study. The Crohn's Disease Activity Index (CDAI), fecal calprotectin, C-reactive protein levels, antibodies (ATI), and trough level (TLI) of IFX were measured at every IFX infusion...
January 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27975236/impact-of-high-dose-vitamin-d3-supplementation-in-patients-with-crohn-s-disease-in-remission-a-pilot-randomized-double-blind-controlled-study
#11
Neeraj Narula, Mohan Cooray, Rebecca Anglin, Zack Muqtadir, Alisha Narula, John K Marshall
AIM: To assess the tolerability and efficacy of high-dose vitamin D3 in patients with Crohn's disease (CD). METHODS: This was a randomized, double-blind placebo-controlled trial of high-dose vitamin D3 at 10,000 IU daily (n = 18) compared to 1000 IU daily (n = 16) for 12 months in patients with CD in remission. The primary outcome was change in serum 25-hydroxy-vitamin D levels. Secondary outcomes included clinical relapse rates and changes in mood scores...
December 14, 2016: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/27965484/influence-of-dentin-deproteinization-on-bonding-degradation-1-year-results
#12
César R Pucci, Natália R Barbosa, Eduardo Bresciani, Karen Ck Yui, Maria Filomena Rl Huhtala, Daphne C Barcellos, Carlos Rg Torres
INTRODUCTION: The decalcification protocol of dentin surface with sodium hypochlorite removes the exposed collagen fibrils and could improve the longevity of the bonding interface. This study evaluated the influence of collagen removal with 10% sodium hypochlorite (10% NaOCl) on the longitudinal shear bond strength (SBS) of adhesives to dentin. MATERIALS AND METHODS: Seventy-two extracted human molars were sectioned and the buccal and lingual surfaces were flattened and acid etched with 37% phosphoric acid for 15 seconds...
December 1, 2016: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/27956202/vaginal-birth-after-cesarean-neonatal-outcomes-and-united%C3%A2-states-birth%C3%A2-setting
#13
Ellen L Tilden, Melissa Cheyney, Jeanne-Marie Guise, Cathy Emeis, Jodi Lapidus, Frances M Biel, Jack Wiedrick, Jonathan M Snowden
BACKGROUND: Women who seek vaginal birth after cesarean delivery may find limited in-hospital options. Increasing numbers of women in the United States are delivering by vaginal birth after cesarean delivery out-of-hospital. Little is known about neonatal outcomes among those who deliver by vaginal birth after cesarean delivery in- vs out-of-hospital. OBJECTIVE: The purpose of this study was to compare neonatal outcomes between women who deliver via vaginal birth after cesarean delivery in-hospital vs out-of-hospital (home and freestanding birth center)...
December 9, 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27939659/lead-and-cadmium-contamination-and-exposure-risk-assessment-via-consumption-of-vegetables-grown-in-agricultural-soils-of-five-selected-regions-of-pakistan
#14
Zahir Ur Rehman, Sardar Khan, Mark L Brusseau, Mohammad Tahir Shah
Rapid urbanization and industrialization result in serious contamination of soil with toxic metals such as lead (Pb) and cadmium (Cd), which can lead to deleterious health impacts in the exposed population. This study aimed to investigate Pb and Cd contamination in agricultural soils and vegetables in five different agricultural sites in Pakistan. The metal transfer from soil-to-plant, average daily intake of metals, and health risk index (HRI) were also characterized. The Pb concentrations for all soils were below the maximum allowable limits (MAL 350 mg kg(-1)) set by State Environmental Protection Administration of China (SEPA), for soils in China, while Cd concentrations in the soils were exceeded the MAL (61...
February 2017: Chemosphere
https://www.readbyqxmd.com/read/27925690/purification-and-characterization-of-a-platelet-aggregation-inhibitor-and-anticoagulant-cc-5_ntase-cd-73-like-from-cerastes-cerastes-venom
#15
Samah Saoud, Fatah Chérifi, Traki Benhassine, Fatima Laraba-Djebari
The present study is the first attempt to report the characterization of a nucleotidase from Cerastes cerastes venom. A 70 kDa 5'-nucleotidase (Cc-5'NTase) was purified to homogeneity. The amino acid sequence of Cc-5'NTase displayed high homology with many nucleotidases. Its activity was optimal at pH 7 with a specific hydrolytic activity toward mono-, di-, and triphosphate adenylated nucleotides. Cc-5'NTase preferentially hydrolyzed ADP and obeyed Michaelis-Menten kinetics. Among the metals and inhibitors tested, Ni(2+) and Mg(2+) completely potentiated enzyme activity, whereas EGTA, PMSF, iodoacetamide, vanillic acid, vanillyl mandelic acid, and 1,10-phenanthroline partially abolished its activity...
December 7, 2016: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/27900423/contamination-fractionation-and-biological-risk-related-to-metals-in-surface-sediments-from-the-largest-deep-freshwater-lake-in-china
#16
Hua-Bing Li, Yang-Guang Gu, Rong Wang, Hui-Bin Lu
The toxicity and mobility of metals in the environment are driven by their specific chemical forms and binding states. However, heavy metal fractionation in sediments from plateau deep lakes in China is rare. This study analyzed surface sediments collected from Fuxian Lake, the largest deep freshwater lake in China; parameters examined included total metal concentrations, chemical partitioning, and biological risk assessment. The average total concentrations (mg/kg) were 7.9 for Cd, 97.6 for Pb, 102.8 for Cr, 60...
November 29, 2016: Archives of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/27868331/patient-resilience-in-the-fracture-orthopaedic-rehabilitation-geriatric-environment
#17
Sabrina Kohler, Sze Ming Loh
OBJECTIVE: To explore the relationship between resilience and rehabilitation outcomes in older orthopaedic patients. METHODS: Geriatric rehabilitation patients admitted to a general metropolitan hospital following a fracture were interviewed face-to-face. Their resilience was assessed using the Connor-Davidson Resilience Scale (CD-RISC), and rehabilitation outcomes were assessed according to functional independence measure (FIM) gain, length of stay, discharge destination and mortality rate...
November 20, 2016: Australasian Journal on Ageing
https://www.readbyqxmd.com/read/27865658/characterization-of-particulate-phase-polycyclic-aromatic-hydrocarbons-emitted-from-incense-burning-and-their-bioreactivity-in-raw264-7-macrophage
#18
Tzu-Ting Yang, Su-Chen Ho, Lu-Te Chuang, Hsiao-Chi Chuang, Ya-Ting Li, Jyun-Jie Wu
This study investigated the effects of particle-bound polycyclic aromatic hydrocarbons (PAHs) produced from burning three incense types on and their bioreactivity in the RAW 264.7 murine macrophage cell line. Gas chromatography/mass spectrometry was used to determine the levels of 16 identified PAHs. Macrophages were exposed to incense particle extracts at concentrations of 0, 3.125, 6.25, 12.5, 25, 50, and 100 μg/mL for 24 h. After exposure, cell viability and nitric oxide (NO) and inflammatory mediator [tumor necrosis factor (TNF)-α] production of the cells were examined...
January 2017: Environmental Pollution
https://www.readbyqxmd.com/read/27852169/fatigue-in-a-population-based-cohort-of-patients-with-inflammatory-bowel-disease-20-years-after-diagnosis-the-ibsen-study
#19
Gert Huppertz-Hauss, Marte Lie Høivik, Lars-Petter Jelsness-Jørgensen, Randi Opheim, Magne Henriksen, Ole Høie, Øistein Hovde, Iril Kempski-Monstad, Inger Camilla Solberg, Jørgen Jahnsen, Geir Hoff, Bjørn Moum, Tomm Bernklev
OBJECTIVE: Fatigue is a major concern for patients with ulcerative colitis (UC) and Crohn's disease (CD), but evidence from population-based studies regarding fatigue in long-standing inflammatory bowel disease (IBD) patients is scarce. Our aims were to assess fatigue scores and the prevalence of chronic fatigue in IBD patients 20 years after diagnosis and to identify variables associated with fatigue in this cohort. METHODS: Twenty years after diagnosis, patients from a cohort with incident IBD were invited to a follow-up visit that included a structured interview, a clinical examination, laboratory tests and the Fatigue Questionnaire (FQ)...
March 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/27848931/serum-albumin-and-c-reactive-protein-albumin-ratio-are-useful-biomarkers-of-crohn-s-disease-activity
#20
Guangming Qin, Jiangfeng Tu, Lingang Liu, Laisheng Luo, Jiaqi Wu, Lisha Tao, Chenjing Zhang, Xiaoge Geng, Xiaojun Chen, Xinbo Ai, Bo Shen, Wensheng Pan
BACKGROUND Serum albumin (ALB) may be low during acute inflammation, but it is also affected by nutritional status. Therefore, we hypothesized that ALB and the C-reactive protein/ALB ratio (CRP/ALB) may be associated with disease activity in patients with Crohn's disease (CD). MATERIAL AND METHODS Altogether, 100 patients with CD and 100 age- and sex-matched healthy volunteers were retrospectively enrolled in the current study. The patients with CD were subdivided into patients with active disease (Crohn's Disease Activity Index >150) and those in remission...
November 16, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
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