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https://www.readbyqxmd.com/read/29454108/detection-of-b-fragilis-group-and-diversity-of-bft-enterotoxin-and-antibiotic-resistance-markers-cepa-cfia-and-nim-among-intestinal-bacteroides-fragilis-strains-in-patients-with-inflammatory-bowel-disease
#1
Marjan Rashidan, Masoumeh Azimirad, Masoud Alebouyeh, Mehdi Ghobakhlou, Hamid Asadzadeh Aghdaei, Mohammad Reza Zali
We compared frequency of the members of B. fragilis group in 100 and 20 colon biopsy specimens of inflammatory bowel disease (IBD) and non-IBD patients. Agar dilution and PCR were orderly used to detect minimal inhibitory concentration of ampicillin, imipenem, and metronidazole, and carriage of related resistance genes cepA, cfi, and nim. B. fragilis group was detected in 38% of IBD (UC: 36/89; CD:1/11) and 25% (5/20) of non-IBD patients. While B. vulgatus (UC: 20/36, CD: 1/2, control: 1/6); B. fragilis (UC: 18/36, CD: 1/2, control: 5/6); B...
February 14, 2018: Anaerobe
https://www.readbyqxmd.com/read/29434453/faecal-calprotectin-and-magnetic-resonance-imaging-in-detecting-crohn-s-disease-endoscopic-postoperative-recurrence
#2
Pierre Baillet, Guillaume Cadiot, Marion Goutte, Felix Goutorbe, Hedia Brixi, Christine Hoeffel, Christophe Allimant, Maud Reymond, Hélène Obritin-Guilhen, Benoit Magnin, Gilles Bommelaer, Bruno Pereira, Constance Hordonneau, Anthony Buisson
AIM: To assess magnetic resonance imaging (MRI) and faecal calprotectin to detect endoscopic postoperative recurrence in patients with Crohn's disease (CD). METHODS: From two tertiary centers, all patients with CD who underwent ileocolonic resection were consecutively and prospectively included. All the patients underwent MRI and endoscopy within the first year after surgery or after the restoration of intestinal continuity [median = 6 mo (5.0-9.3)]. The stools were collected the day before the colonoscopy to evaluate faecal calprotectin level...
February 7, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29420227/azithromycin-and-metronidazole-versus-metronidazole-based-therapy-for-the-induction-of-remission-in-mild-to-moderate-paediatric-crohn-s-disease-a-randomised-controlled-trial
#3
Arie Levine, Michal Kori, Jarek Kierkus, Rotem Sigall Boneh, Malgorzata Sladek, Johanna C Escher, Eytan Wine, Baruch Yerushalmi, Jorge Amil Dias, Ron Shaoul, Gigi Veereman Wauters, Mona Boaz, Guila Abitbol, Athos Bousvaros, Dan Turner
OBJECTIVE: Crohn's disease (CD) pathogenesis associated with dysbiosis and presence of pathobionts in the lumen, intracellular compartments and epithelial biofilms. Azithromycin is active in all three compartments. Our goal was to evaluate if azithromycin-based therapy can improve response and induce remission compared with metronidazole alone in paediatric CD. DESIGN: This blinded randomised controlled trial allocated children 5-18 years with 10<Pediatric Crohn's Disease Activity Index (PCDAI)≤40 to azithromycin 7...
February 2, 2018: Gut
https://www.readbyqxmd.com/read/29391828/toxic-elements-as-biomarkers-for-breast-cancer-a-meta-analysis-study
#4
REVIEW
Leila Jouybari, Marzieh Saei Ghare Naz, Akram Sanagoo, Faezeh Kiani, Fatemeh Sayehmiri, Kourosh Sayehmiri, Ali Hasanpour Dehkordi
Aims and background: Breast cancer (BC) is responsible for a large proportion of incidence of cancer in the world. Identifying the risk factors contributing to the incidence of BC is crucial to find efficient preventive and management strategies for this disease. Several studies have examined Arsenic (As), Cadmium (Cd), and Nickel (Ni) as risk factors for BC. The present study aimed at studying the link between As, Cd, and Ni concentrations and BC by using a meta-analysis. Materials and methods: All case-control studies addressing the relationship between As, Cd, and Ni concentrations with BC were identified through electronic search databases (Scopus, ISI Web of Science, PubMed, EmBase, and Cochrane Library)...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/29381940/topical-steroids-eye-drops-in-conjunctival-reactive-lymphoid-hyperplasia-case-report
#5
Bernardo Rodrigues Mendes Moraes, Micael Valtoni Dantas do Nascimento, Epitácio Dias da Silva Neto, Ruth Miyuki Santo
RATIONALE: Conjunctival lymphoproliferative lesions constitute a significant diagnostic challenge and it is essential to exclude neoplastic lesions. Histopathological and immunohistochemical tests are very useful in establishing the correct diagnosis. Reactive lymphoid hyperplasia (RLH) is part of a spectrum of lymphocytic infiltrative disorders. Evidence is scarce regarding appropriate treatment of conjunctival RLH. We report a case treated with topical corticosteroid. PATIENT CONCERNS: A 40 year-old female presented with a 7-month history of a slow growth tumor in the superior conjunctiva of the right eye...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29374617/efficacy-of-medical-therapies-for-fistulizing-crohn-s-disease-systematic-review-and-meta-analysis
#6
REVIEW
Matthew J Lee, Claire E Parker, Sarah R Taylor, Leonardo Guizzetti, Brian G Feagan, Alan J Lobo, Vipul Jairath
BACKGROUND & AIMS: Fistulas are debilitating complications of Crohn's disease (CD) that affect up to 50% of patients. We conducted a systematic review and meta-analysis of randomized controlled trials to assess the efficacy of treatments for fistulizing CD. METHODS: We searched publication databases from inception through December 13, 2016 for trials comparing the efficacy of a therapeutic agent (single or combination) with placebo or another active therapy in adult patients with any form of fistulizing CD...
January 25, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29374569/diketopiperazines-and-2h-pyran-2-ones-with-antioxidant-activity-from-the-rice-fermented-with-aspergillus-luchuensis
#7
Shanshan Sun, Ke Ma, Qiaoqiao Tao, Junjie Han, Li Bao, Li Liu, Hongwei Liu
Aspergillus luchuensis is widely used as a starter of saccharification in the koji industry, but no secondary metabolites have been reported from this fungus. Herein, we report the isolation and identification of four new diketopiperazine derivatives (1-4), one new methyl 4-(3-acetyl-2, 6-dihydroxyphenyl)-2-methoxybutanoate (5), and six known compounds (6-11) from the rice koji of A. luchuensis. The structures of 1-5 were determined by extensive spectral analysis including 1D and 2D NMR, HRESIMS, and CD, and ECD calculation...
January 25, 2018: Fitoterapia
https://www.readbyqxmd.com/read/29369687/a-limited-survey-of-heavy-metal-concentrations-in-fresh-and-frozen-cuttlefish-ink-and-mantle-used-as-food
#8
Daniele Conficoni, Leonardo Alberghini, Elisa Bissacco, Barbara Contiero, Valerio Giaccone
Cuttlefish ink is consumed as a delicacy worldwide. The current study is the first assessment of heavy metal concentrations in cuttlefish ink versus mantle under different storage methods. A total of 212 samples (64 of fresh mantle, 42 of frozen mantle, 64 of fresh ink, and 42 of frozen ink) were analyzed for the detection of the following heavy metals: arsenic (As), chromium (Cr), iron (Fe), lead (Pb), mercury (Hg), and cadmium (Cd). The median As concentrations were 12.9 mg/kg for fresh mantle, 8.63 mg/kg for frozen mantle, 10...
January 25, 2018: Journal of Food Protection
https://www.readbyqxmd.com/read/29361106/disagreement-among-gastroenterologists-using-the-mayo-and-rutgeerts-endoscopic-scores
#9
Samuel Raimundo Fernandes, João Sebastião Lopes Dias Pinto, Pedro Marques da Costa, Luís Correia
Background: Endoscopy is routinely performed in patients with inflammatory bowel disease to evaluate disease severity and guide important clinical decisions. However, variability in the interpretation of endoscopic findings can significantly impact patient management. Methods: Fifty-eight gastroenterologists were invited to participate in an online survey including pictures and video recordings of colonoscopies performed in patients with ulcerative colitis (UC) and Crohn's disease (CD)...
January 18, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29358116/cadmium-and-atherosclerosis-a-review-of-toxicological-mechanisms-and-a-meta-analysis-of-epidemiologic-studies
#10
REVIEW
Alexey A Tinkov, Tommaso Filippini, Olga P Ajsuvakova, Margarita G Skalnaya, Jan Aaseth, Geir Bjørklund, Eugenia R Gatiatulina, Elizaveta V Popova, Olga N Nemereshina, Pai-Tsang Huang, Marco Vinceti, Anatoly V Skalny
Cadmium has been proposed to be the one of the factors of atherosclerosis development, although the existing data are still controversial. The primary objective of the present study is the review and the meta-analysis of studies demonstrating the association between Cd exposure and atherosclerosis as well as review of the potential mechanisms of such association. We performed a systematic search in the PubMed-Medline database using the MeSH terms cadmium, cardiovascular disease, atherosclerosis, coronary artery disease, myocardial infarction, stroke, mortality and humans up through December 20, 2017...
January 19, 2018: Environmental Research
https://www.readbyqxmd.com/read/29340457/diet-quality-of-patients-with-chronic-chagas-disease-in-a-tertiary-hospital-a-case-control-study
#11
Mariana Pereira de Castilhos, Grazielle Vilas Bôas Huguenin, Paulo Rogério Melo Rodrigues, Emília Matos do Nascimento, Basílio de Bragança Pereira, Roberto Coury Pedrosa
INTRODUCTION: Nutritional status has been implicated in the modulation of the immune response, possibly augmenting the pathogenesis of Chagas disease (Cd). We evaluated diet quality and nutritional status in adults and elderly patients with chronic Cd in a tertiary hospital. METHODS: A case-control study of Cd patients was conducted, paired for gender, age, and co-morbidities with non-Cd patients. Anthropometric measurements and food frequency questionnaire was used, and diet quality was assessed by the Brazilian Healthy Eating Index-Revised (BHEI-R)...
November 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29315161/using-quality-improvement-to-increase-utilization-of-enteral-therapy-in-pediatric-crohn-disease-results-and-outcomes
#12
Ala K Shaikhkhalil, Brendan Boyle, Jennifer Smith, Jennifer L Dotson, Amy Donegan, Sandra C Kim, Ross M Maltz, Wallace Crandall
INTRODUCTION: Exclusive enteral nutrition (EEN) for induction of remission in children with Crohn's disease (CD) is recommended as first line therapy, but underutilized in the United States related to real and perceived barriers. We hypothesized that quality improvement (QI) methodology could increase use of EEN. METHODS: We developed, implemented, and revised an algorithm and a set of tools to facilitate use of EEN. Through a series of Plan Do Study Act cycles, the approach was modified to overcome provider and patient/family barriers...
January 6, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29311226/outcome-of-endoscopic-vs-microsurgical-transsphenoidal-resection-for-cushing-s-disease
#13
REVIEW
Nidan Qiao
INTRODUCTION: It is unclear whether the proportions of remission and the recurrence rates differ between endoscopic transsphenoidal surgery (TS) and microscopic TS in Cushing's disease (CD); thus, we conducted a systematic review and meta-analysis to evaluate studies of endoscopic TS and microscopic TS. METHODS: We conducted a comprehensive search of PubMed to identify relevant studies. Remission and recurrence were used as outcome measures following surgical treatment of CD...
January 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29302908/heavy-metals-in-handloom-dyeing-effluents-and-their-biosorption-by-agricultural-byproducts
#14
Kamrun Nahar, Md Abul Khair Chowdhury, Md Akhter Hossain Chowdhury, Afzal Rahman, K M Mohiuddin
The Madhabdi municipality in the Narsingdi district of Bangladesh is a well-known area for textile, handloom weaving, and dyeing industries. These textile industries produce a considerable amount of effluents, sewage sludge, and solid waste materials every day that they directly discharge into surrounding water bodies and agricultural fields. This disposal poses a serious threat to the overall epidemic and socio-economic pattern of the locality. This research entailed the collection of 34 handloom-dyeing effluent samples from different handloom-dyeing industries of Madhabdi, which were then analyzed to determine the contents of the heavy metals iron (Fe), zinc (Zn), copper (Cu), chromium (Cr), manganese (Mn), lead (Pb), and cadmium (Cd)...
January 4, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29291413/impact-of-recommended-changes-in-labor-management-for-prevention-of-the-primary-cesarean-delivery
#15
Claire Thuillier, Sophie Roy, Violaine Peyronet, Thibaud Quibel, Aurélie Nlandu, Patrick Rozenberg
BACKGROUND: The dramatic rise in cesarean delivery (CD) rates worldwide in recent decades, without evidence of a concomitant decrease in cerebral palsy rates, has raised concerns about its potential negative consequences for maternal and infant health. In 2014, the American College of Obstetricians and Gynecologists and the Society for Maternal-Fetal Medicine jointly published an Obstetric Care Consensus for safe prevention of the primary cesarean delivery. OBJECTIVE: We sought to assess whether modification of our protocol to implement these recommendations helped to decrease our primary CD rate safely...
December 29, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29279752/difference-in-spinal-sagittal-alignment-and-health-related-quality-of-life-between-males-and-females-with-cervical-deformity
#16
Shin Oe, Daisuke Togawa, Go Yoshida, Tomohiko Hasegawa, Yu Yamato, Sho Kobayashi, Tatsuya Yasuda, Tomohiro Banno, Yuki Mihara, Yukihiro Matsuyama
Study Design: Large cohort study. Purpose: To clarify spinal sagittal alignment and health-related quality of life (HRQOL) according to sex in volunteers aged >50 years with cervical deformity (CD). Overview of Literature: Adult spinal deformities, especially those associated with lumbosacral lesions, are more frequent in females; however, CD is observed to a greater extent in males. Methods: We divided 656 volunteers (263 males, 393 females; age, 50-89 years [mean, 73 years]) as follows: males with CD (CDM; 82 patients); males without CD (NCDM, 181); females with CD (CDF, 36); and females without CD (NCDF, 357)...
December 2017: Asian Spine Journal
https://www.readbyqxmd.com/read/29277048/comparison-of-planned-caesarean-delivery-and-planned-vaginal-delivery-in-women-with-a-twin-pregnancy-a-nation-wide-cohort-study
#17
Simone M T A Goossens, Sabine Ensing, Mark A H B M van der Hoeven, Frans J M E Roumen, Jan G Nijhuis, Ben W Mol
OBJECTIVE: To compare, in women with twin pregnancy with the first twin in cephalic position, neonatal morbidity and mortality rates after planned Ceasarean delivery (CD) versus planned vaginal delivery (VD). STUDY DESIGN: A nationwide cohort study on women pregnant with twins and the first child in cephalic position, who delivered between 32 + 0-41 + 0 weeks between 2000 and 2012 in the Netherlands, using multivariate logistic regression analysis to compare neonatal morbidity and mortality according to planned delivery mode, and looked at subgroups 32 + 0-36 + 6 and 37 + 0-41 + 0 weeks...
December 15, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29260635/comparison-of-two-indices-to-annotate-complications-after-radical-nephroureterectomy
#18
Rosa Park, Christopher Rjepaj, Kathleen Lehman, Jay D Raman
INTRODUCTION: The Clavien-Dindo (CD) and Comprehensive Complication Index (CCI) are two grading systems that annotate adverse events following surgical procedures. We compare these two classification systems in a cohort of patients undergoing radical nephroureterectomy (RNU). MATERIALS AND METHODS: The charts of 110 consecutive RNU patients were reviewed for complications occurring within 30 days of surgery. Grading by the CD classification system and values for CCI were calculated...
December 2017: Canadian Journal of Urology
https://www.readbyqxmd.com/read/29258369/high-treatment-persistence-rate-and-significant-endoscopic-healing-among-real-life-patients-treated-with-vedolizumab-a-finnish-nationwide-inflammatory-bowel-disease-cohort-study-finvedo
#19
Tero Ylisaukko-Oja, Jaakko Aaltonen, Heikki Nuutinen, Timo Blomster, Airi Jussila, Markku Pajala, Kimmo Salminen, Veikko Moilanen, Kalle Hakala, Mikko Kellokumpu, Kari Toljamo, Henna Rautiainen, Juha Kuisma, Markku Peräaho, Pauliina Molander, Jouni Silvennoinen, Ville Liukkonen, Hans Henricson, Jyrki Tillonen, Mirva Esterinen, Christian Nielsen, Eija Hirsi, Margus Lääne, Ulla-Maija Suhonen, Ilkka Vihriälä, Petri Mäkelä, Mika Puhto, Jari Punkkinen, Hannu Sulonen, Sauli Herrala, Jari Jokelainen, Klaus Tamminen, Taina Sipponen
OBJECTIVES: The efficacy and tolerability of vedolizumab in the treatment of inflammatory bowel diseases (IBD) has been demonstrated in an extensive GEMINI clinical trial programme. Clinical trials represent highly selected patient populations and, therefore, it is important to demonstrate effectiveness in real-life clinical practice. We set out to assess real-world treatment outcomes of vedolizumab in a nationwide cohort of treatment refractory Finnish Crohn's disease (CD) and ulcerative colitis (UC) patients...
December 19, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29248781/drivers-of-cervical-deformity-have-a-strong-influence-on-achieving-optimal-radiographic-and-clinical-outcomes-at-1-year-following-cervical-deformity-surgery
#20
Peter G Passias, Cole Bortz, Samantha Horn, Frank Segreto, Gregory Poorman, Cyrus Jalai, Alan Daniels, D Kojo Hamilton, Han Jo Kim, Daniel Sciubba, Justin S Smith, Brian Neuman, Christopher Shaffrey, Virginie Lafage, Themistocles Protopsaltis, Christopher Ames, Robert Hart, Gregory Mundis, Robert Eastlack
OBJECTIVE: The primary driver (PD) of cervical malalignment is important in characterizing cervical deformity(CD) and should be included in fusion to achieve alignment and quality-of-life goals. This study aims to define how PDs improve understanding of the mechanisms of cervical deformity, and assesses the impact of driver region on re-alignment/outcomes. METHODS: Inclusion: radiographic cervical deformity, >18 years, 1-year follow-up. PD apex was classified by spinal region: cervical, cervicothoracic junction(CTJ), thoracic, or spino-pelvic by panel of spine deformity surgeons...
December 14, 2017: World Neurosurgery
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