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https://www.readbyqxmd.com/read/29027293/determination-of-chemical-identity-and-occupancy-from-experimental-density-maps
#1
Jimin Wang
Three basic electronic properties of molecules, electron density (ED), charge density (CD), and electrostatic potentials (ESP), are dependent on both atomic mobility and occupancy of components in the molecules. Small protein subunits may bind large macromolecular complexes with a reduced occupancy or an increased atomic mobility or both due to affinity-based functional regulation, and so may substrates, products, cofactors, ions or solvent molecule to the active sites of enzymes. A quantitative theory is presented in this study that describes the dependence of atomic functions on atomic B-factor in Fourier transforms of the corresponding maps...
October 13, 2017: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/28993901/collagen-gel-droplet-embedded-culture-drug-sensitivity-test-for-adjuvant-chemotherapy-after-complete-resection-of-non-small-cell-lung-cancer
#2
Masayoshi Inoue, Hajime Maeda, Yukiyasu Takeuchi, Kenjiro Fukuhara, Yasushi Shintani, Yasunobu Funakoshi, Soichiro Funaki, Takashi Nojiri, Takashi Kusu, Hidenori Kusumoto, Toru Kimura, Meinoshin Okumura
PURPOSE: We conducted a prospective clinical study to individualize adjuvant chemotherapy after complete resection of non-small-cell lung cancer (NSCLC), based on the drug sensitivity test. METHODS: Patients with resectable c-stage IB-IIIA NSCLC were registered between 2005 and 2010. We performed the collagen gel droplet-embedded culture drug sensitivity test (CD-DST) on a fresh surgical specimen to assess in vitro chemosensitivity and evaluated the prognostic outcome after adjuvant chemotherapy with carboplatin/paclitaxel based on the CD-DST...
October 9, 2017: Surgery Today
https://www.readbyqxmd.com/read/28990139/association-between-morphological-patterns-of-myometrial-invasion-and-cancer-stem-cell-markers-in-endometrial-endometrioid-carcinoma
#3
Ji Y Park, Daegy Hong, Ji Young Park
In endometrial endometrioid adenocarcinoma (EEC), the depth of myometrial invasion (MI) is an important parameter for determining whether additional treatment is warranted. The present study investigated the association between MI patterns, cancer stem cell (CSC) phenotypes, and their clinicopathological significance in EEC. A total of 73 cases of EEC with MI were examined in this study. Haematoxylin and eosin-stained tissue specimens were analysed for MI pattern, which was categorised as infiltrating; expansile; adenomyosis (AM)-like; or microcystic, elongated, and fragmented (MELF)-type...
October 8, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28983442/minimal-rectal-toxicity-in-the-setting-of-comorbid-crohn-s-disease-following-prostate-cancer-radiotherapy-with-a-hydrogel-rectal-spacer
#4
Raj Singh, Philip S Jackson, Mollie Blake, James Cutlip, Sanjeev Sharma
We present one of the first cases of a prostate cancer (PCa) patient with inflammatory bowel disease (IBD) treated with intensity-modulated radiotherapy (IMRT) and a hydrogel rectal spacer. A 73-year-old male with a past medical history significant for Crohn's disease (CD) and the recent diagnosis of T1cN0M0 high-risk PCa was referred for definitive radiotherapy. Given the patient's history of CD and the possible increased risk of gastrointestinal (GI) toxicity and disease exacerbation, prior to IMRT, a hydrogel spacer was placed between the prostate and the anterior rectal wall to further minimize irradiation to the rectum...
August 1, 2017: Curēus
https://www.readbyqxmd.com/read/28982831/association-of-asthma-chronic-obstructive-pulmonary-disease-overlap-syndrome-with-coronary-artery-disease-cardiac-dysrhythmia-and-heart-failure-a-population-based-retrospective-cohort-study
#5
Jun-Jun Yeh, Yu-Feng Wei, Cheng-Li Lin, Wu-Huei Hsu
OBJECTIVES: Patients with asthma-chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS) and cardiovascular diseases (CVDs) share common risk factors. However, the association between ACOS and the incidence of CVDs has not been reported. This study investigated the relationship between CVDs and ACOS in the general population. SETTING: Data were obtained from Taiwan's National Health Insurance Research Database for the period 2000 to 2010. PARTICIPANTS: The ACOS cohort comprised patients (n=5814) who had received a diagnosis of asthma and COPD...
October 5, 2017: BMJ Open
https://www.readbyqxmd.com/read/28982150/ocular-biometric-measurements-in-cataract-surgery-candidates-in-portugal
#6
Tiago B Ferreira, Kenneth J Hoffer, Filomena Ribeiro, Paulo Ribeiro, João G O'Neill
OBJECTIVE: Describe the ocular biometric parameters and their associations in a population of cataract surgery candidates. METHODS: A cross-sectional study of 13,012 eyes of 6,506 patients was performed. Biometric parameters of the eyes were measured by optical low-coherence reflectometry. The axial length (AL), mean keratometry (K) and astigmatism, anterior chamber depth (ACD) (epithelium to lens), lens thickness (LT), and Corneal Diameter (CD) were evaluated. RESULTS: The mean age was 69 ± 10 years (44-99 years)...
2017: PloS One
https://www.readbyqxmd.com/read/28974043/multi-elements-in-source-water-drinking-and-surface-water-within-five-cities-from-the-semi-arid-and-arid-region-nw-china-occurrence-spatial-distribution-and-risk-assessment
#7
Ting Wu, Xiaoping Li, Tao Yang, Xuemeng Sun, Howard W Mielke, Yue Cai, Yuwei Ai, Yanan Zhao, Dongying Liu, Xu Zhang, Xiaoyun Li, Lijun Wang, Hongtao Yu
The purpose of this study was to identify the concentration of multi-elements (MEs) in source water (surface and drinking water) and assess their quality for sustainability. A total of 161 water samples including 88 tap drinking waters (DW) and 73 surface waters (SW) were collected from five cities in Xi'an, Yan'an, Xining, Lanzhou, and Urumqi in northwestern China. Eighteen parameters including pH, electrical conductivity (EC), total organic carbon (TOC) total nitrogen (TN), chemical compositions of anions (F(-), Cl(-), NO₃(-),HCO₃(-), SO₄(2-)), cations (NH₄⁺, K⁺, Na⁺, Ca(2+),Mg(2+)), and metals (lead (Pb), chromium (Cr), cadmium (Cd), copper (Cu)) were analyzed in the first time at the five cities ...
October 2, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28951193/impact-of-toxicity-on-survival-for-older-adult-patients-after-cd34-selected-allogeneic-hematopoietic-stem-cell-transplantation
#8
Gunjan L Shah, Michael Scordo, Satyajit Kosuri, Diego Adrianzen Herrera, Christina Cho, Molly A Maloy, Jimmy Nieves, Sean M Devlin, Taylor Borrill, Dean C Carlow, Scott T Avecilla, Richard C Meagher, Richard J O'Reilly, Ann A Jakubowski, Esperanza B Papadopoulos, Guenther Koehne, Boglarka Gyurkocza, Hugo Castro-Malaspina, Brian C Shaffer, Miguel-Angel Perales, Sergio A Giralt, Roni Tamari
Ex vivo CD 34+ selection prior to allogeneic hematopoietic stem Cell transplantation (allo-HCT) reduces GVHD without increasing relapse, but usually requires myeloablative conditioning. We aimed to identify toxicity patterns in older patients & the association with overall survival (OS) & non-relapse mortality (NRM). We conducted a retrospective analysis of 200 pts who underwent CD34+ selection allo-HCT using the ClinicMACS® system between 2006-2012. All grade 3-5 toxicities by CTCAE v4.0 were collected. Eighty patients ≥ 60yrs with a median age of 64 (range 60-73) were compared to 120 pts <60yrs...
September 22, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28919192/magnetic-resonance-index-of-activity-maria-and-clermont-score-are-highly-and-equally-effective-mri-indices-in-detecting-mucosal-healing-in-crohn-s-disease
#9
Anthony Buisson, Bruno Pereira, Marion Goutte, Maud Reymond, Christophe Allimant, Hélène Obritin-Guilhen, Gilles Bommelaer, Constance Hordonneau
BACKGROUND: Magnetic resonance index of activity (MaRIA) and Clermont score are currently the two main MRI indices that have been validated compared to endoscopy in Crohn's disease (CD). AIMS: To compare the accuracy of MaRIA and Clermont score in assessing CD mucosal healing. METHODS: Fourty-four CD patients underwent prospectively and consecutively MRI and colonoscopy. RESULTS: Considering 207 segments, MaRIA>7 and Clermont score>8...
August 31, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28871406/heavy-metal-contamination-in-fish-callinectis-amnicola-from-an-estuarine-creek-in-the-niger-delta-nigeria-and-health-risk-evaluation
#10
M Moslen, C A Miebaka
Heavy metal bioconcentration in crabs from an estuarine creek in the Niger Delta was examined using atomic absorption spectrophotometry. Health risk via human exposure to metal toxicity was evaluated. Mean metal levels (µg/g) were Cr 2.32 ± 0.71, Ni 2.76 ± 0.48, Cu 12.94 ± 3.53, Pb 5.67 ± 1.03, Ag 1.83 ± 0.71 and Cd 0.73 ± 0.14 with significant difference (p < 0.001) between periods. Ni, Pb and Cd had values above FAO/WHO recommended limits. Estimated daily intake values were below the reference oral doses and the target hazard quotient was <1 for each metal examined while hazard index for all metals was also <1...
September 4, 2017: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28843898/role-of-heavy-metals-in-structuring-the-microbial-community-associated-with-particulate-matter-in-a-tropical-estuary
#11
V A Sheeba, Anas Abdulaziz, T R Gireeshkumar, Anirudh Ram, P S Rakesh, C Jasmin, P S Parameswaran
Particulate matter (PM), which are chemically and biochemically complicated particles, accommodate a plethora of microorganisms. In the present study, we report the influence of heavy metal pollution on the abundance and community structure of archaea and bacteria associated with PM samples collected from polluted and non-polluted regions of Cochin Estuary (CE), Southwest coast of India. We observed an accumulation of heavy metals in PM collected from CE, and their concentrations were in the order Fe > Zn > Mn > Cr > Pb > Cu > Cd > Co > Ni...
August 24, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28840194/rectus-muscle-reapproximation-at-cesarean-delivery-and-postoperative-pain-a-randomized-controlled-trial
#12
Deirdre J Lyell, Mariam Naqvi, Amy Wong, Renata Urban, Brendan Carvalho
Objective  Rectus muscle reapproximation at cesarean delivery (CD) is performed frequently by some obstetricians; however, the effect on postoperative pain is unclear. To this end, we investigated whether rectus muscle reapproximation increases postoperative pain. Materials and Methods  This is a prospective, double-blind, randomized controlled trial of women undergoing primary CD with singleton or twin pregnancy at >35 weeks' gestation. Women were randomized to rectus muscle reapproximation with three interrupted sutures or no reapproximation...
July 2017: Surg J (N Y)
https://www.readbyqxmd.com/read/28812193/cost-analysis-of-robot-assisted-choledochotomy-and-common-bile-duct-exploration-as-an-option-for-complex-choledocholithiasis
#13
Ahmed Almamar, Nawar A Alkhamesi, Ward T Davies, Christopher M Schlachta
AIM: The aim of this study is to evaluate the clinical outcomes and cost-effectiveness of elective, robot-assisted choledochotomy and common bile duct exploration (RCD/CBDE) compared to open surgery for ERCP refractory choledocholithiasis. METHOD: A prospective database of all RCD/CBDE has been maintained since our first procedure in April 2007 though April 2016. With ethics approval, this database was compared with all contemporaneous elective open procedures (OCD/CBDE) performed since March 2005...
August 15, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28796069/assessment-of-therapeutic-response-in-crohn-s-disease-using-quantitative-dynamic-contrast-enhanced-mri-dce-mri-parameters-a-preliminary-study
#14
Jianguo Zhu, Faming Zhang, Jinfa Zhou, Haige Li
The aim of the study was to investigate dynamic contrast enhanced MRI (DCE-MRI) as a potential marker to assess the therapeutic responses of fecal microbiota transplantation (FMT) in patients with Crohn's disease (CD) and to determine the parameter or combination of parameters most strongly associated with changes in clinical indicators after treatment.In 22 CD patients, DCE-MRI was performed with a 3.0T scanner. Parameters of DCE-MRI (vascular transfer constant [K] and blood volume [BV]) in the terminal ileum were compared between before and day 90 after FMT treatment...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28753178/caesarean-section-on-the-risk-of-celiac-disease-in-the-offspring-the-teddy-study
#15
Sibylle Koletzko, Hye-Seung Lee, Andreas Beyerlein, Carin A Aronsson, Michael Hummel, Edwin Liu, Ville Simell, Kalle Kurppa, Åke Lernmark, William Hagopian, Marian Rewers, Jin-Xiong She, Olli Simell, Jorma Toppari, Anette-G Ziegler, Jeffrey Krischer, Daniel Agardh
OBJECTIVE: Caesarean section (C-section) is associated with various immune-mediated diseases in the offspring. We investigated the relationship between mode of delivery and celiac disease (CD) and CD autoimmunity (CDA) in a multinational birth cohort. METHODS: From 2004 to 2010 infants from the general population who tested positive for HLA DR3-DQ2 or DR4-DQ8 were enrolled in The Environmental Determinants for Diabetes in the Young (TEDDY) study. Children were annually screened for transglutaminase autoantibodies, if positive re-tested after 3-6 months and those persistently positive defined as CDA...
July 27, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28741684/how-does-mandibular-bone-atrophy-influence-the-masticatory-function-ohrqol-and-satisfaction-in-overdenture-wearers-clinical-results-until-1-year-post-loading
#16
R M Marcello-Machado, F Faot, A J Schuster, A M Bielemann, O L Chagas Júnior, A A Del Bel Cury
This longitudinal clinical study investigated the differences in the masticatory function (MF), satisfaction and oral health-related quality of life (OHRQoL) between atrophic patients (AP) and non-atrophic patients (NAP) before and after rehabilitation with mandibular overdenture (MO). Twenty-six complete denture (CD) wearers were categorised into two groups, according to the mandibular bone atrophy (MBA) degree. MF was evaluated before and after 1, 3, 6 and 12 months of the MO loading via 2 standardised tests: (i) MP, masticatory performance (MP_X50, MPB, ME 5·6, ME 2·8) and (ii) ST, swallowing threshold (time, number of cycles, ST_X50, STB, ME 5·6, ME 2·8)...
November 2017: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/28721615/phycoremediation-potential-of-marine-microalga-tetraselmis-indica-on-secondary-treated-domestic-sewage-for-nutrient-removal-and-biodiesel-production
#17
Amit, Rajesh Chandra, Uttam Kumar Ghosh, Jagdeep Kumar Nayak
Marine microalga Tetraselmis indica (T. indica) was cultivated in secondary treated domestic sewage (STDS) in batch mode. Optimization studies showed that after 14 days of cultivation period, highest biomass yield reached was 0.88 ± 0.04 g/L at the optimum temperature of 27 ± 1 °C and light intensity of 135 μmol m(-2) s(-1). T. indica removed about 60.93% phosphate, 78.46% nitrate, 72.94% chemical oxygen demand (COD), 73.17% biological oxygen demand (BOD), 98.90% total dissolved solids (TDS) and heavy metals (83...
July 18, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28718999/resilience-is-decreased-in-irritable-bowel-syndrome-and-associated-with-symptoms-and-cortisol-response
#18
S H Park, B D Naliboff, W Shih, A P Presson, E J Videlock, T Ju, L Kilpatrick, A Gupta, E A Mayer, L Chang
BACKGROUND: Irritable bowel syndrome (IBS) is a stress-sensitive disorder associated with early adverse life events (EALs) and a dysregulated hypothalamic-pituitary-adrenal (HPA) axis. Resilience is the ability to recover and adapt positively to stress but has not been well studied in IBS. The aims of this study are to compare resilience in IBS and healthy controls (HCs) and to assess its relationships with IBS symptom severity, quality of life (QOL), EALs, and HPA axis response. METHODS: Two hundred fifty-six subjects (154 IBS, 102 HCs) completed questionnaires for resilience (Connor-Davidson Resilience Scale [CD-RISC] and Brief Resilience Scale [BRS]), IBS symptoms, IBS-QOL, and EALs...
July 18, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28717272/have-we-overcome-the-complications-of-laparoscopic-nephrectomy-a-prospective-cohort-study-using-the-modified-clavien-dindo-scale
#19
Tapan Agrawal, Rajeev Kumar, Prabhjot Singh, Ashish Saini, Amlesh Seth, Premnath Dogra
INTRODUCTION: Apart from the complexity of procedure and surgeon's experience, surgical complication rates depend on case definition and method of recording data. We prospectively evaluated the complications of laparoscopic nephrectomy (LN) in a current cohort of patients, graded on the modified Clavien-Dindo (CD) scale and compared them with historical cohorts. METHODS: In the Institutional Review Board approved protocol, all patients undergoing LN over a 30-month were enrolled in the study...
July 2017: Indian Journal of Urology: IJU: Journal of the Urological Society of India
https://www.readbyqxmd.com/read/28714774/small-sided-games-in-elite-soccer-does-one-size-fits-all
#20
Mathieu Lacome, Ben M Simpson, Yannick Cholley, Philippe Lambert, Martin Buchheit
PURPOSE: To compare the peak intensity of typical Small Sided Games (SSGs) with those of official matches in terms of running demands and mechanical work over different rolling average durations and playing positions. METHOD: Data were collected in 21 players (25±5 y, 181±7 cm, 77±7 kg) belonging to an elite French football team. SSG data were collected over two seasons during typical training sessions (249 files, 12±4 per player) and official matches (n=12)...
July 17, 2017: International Journal of Sports Physiology and Performance
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